-- dump date 20140620_074217 -- class Genbank::misc_feature -- table misc_feature_note -- id note 282458000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 282458000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 282458000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458000004 Walker A motif; other site 282458000005 ATP binding site [chemical binding]; other site 282458000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 282458000007 Walker B motif; other site 282458000008 arginine finger; other site 282458000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 282458000010 DnaA box-binding interface [nucleotide binding]; other site 282458000011 Pfam match to entry PF00308 bac_dnaA, Bacterial dnaA protein, score 678.90, E-value 1.5e-228 282458000012 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000013 PS01008 DnaA protein signature. 282458000014 DNA polymerase III subunit beta; Validated; Region: PRK05643 282458000015 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 282458000016 putative DNA binding surface [nucleotide binding]; other site 282458000017 dimer interface [polypeptide binding]; other site 282458000018 beta-clamp/clamp loader binding surface; other site 282458000019 beta-clamp/translesion DNA polymerase binding surface; other site 282458000020 Pfam match to entry PF00712 DNA_pol3_beta, DNA polymerase III beta subunit, N-terminal domain, score 222.50, E-value 6e-63 282458000021 Pfam match to entry PF02767 DNA_pol3_beta_2, DNA polymerase III beta subunit, central domain, score 220.50, E-value 4.2e-67 282458000022 Pfam match to entry PF02768 DNA_pol3_beta_3, DNA polymerase III beta subunit, C-terminal domain, score 207.80, E-value 1.7e-58 282458000023 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 282458000024 recF protein; Region: recf; TIGR00611 282458000025 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 282458000026 Walker A/P-loop; other site 282458000027 ATP binding site [chemical binding]; other site 282458000028 Q-loop/lid; other site 282458000029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282458000030 ABC transporter signature motif; other site 282458000031 Walker B; other site 282458000032 D-loop; other site 282458000033 H-loop/switch region; other site 282458000034 Pfam match to entry PF00470 RecF, RecF protein, score 42.50, E-value 7.2e-11 282458000035 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000036 PS00617 RecF protein signature 1. 282458000037 Pfam match to entry PF00470 RecF, RecF protein, score 16.20, E-value 0.0014 282458000038 PS00618 RecF protein signature 2. 282458000039 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 282458000040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458000041 Mg2+ binding site [ion binding]; other site 282458000042 G-X-G motif; other site 282458000043 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 282458000044 anchoring element; other site 282458000045 dimer interface [polypeptide binding]; other site 282458000046 ATP binding site [chemical binding]; other site 282458000047 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 282458000048 active site 282458000049 putative metal-binding site [ion binding]; other site 282458000050 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 282458000051 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 86.60, E-value 1.4e-22 282458000052 PS00154 E1-E2 ATPases phosphorylation site. 282458000053 Pfam match to entry PF00204 DNA_topoisoII, DNA topoisomerase II (N-terminal region), score 349.80, E-value 2.9e-101 282458000054 PS00177 DNA topoisomerase II signature. 282458000055 Pfam match to entry PF01751 Toprim, Toprim domain, score 41.60, E-value 1.8e-08 282458000056 Pfam match to entry PF00986 DNA_gyraseB_C, DNA gyrase B subunit, carboxyl terminus, score 151.90, E-value 1.1e-41 282458000057 DNA gyrase subunit A; Validated; Region: PRK05560 282458000058 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 282458000059 CAP-like domain; other site 282458000060 active site 282458000061 primary dimer interface [polypeptide binding]; other site 282458000062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 282458000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 282458000064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 282458000065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 282458000066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 282458000067 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 282458000068 Pfam match to entry PF00521 DNA_topoisoIV, DNA gyrase/topoisomerase IV, subunit A, score 1052.50, E-value 0 282458000069 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000070 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 282458000071 putative substrate binding site [chemical binding]; other site 282458000072 putative ATP binding site [chemical binding]; other site 282458000073 Pfam match to entry PF01256 UPF0031, Uncharacterized protein family UPF0031, score 235.40, E-value 7.9e-67 282458000074 PS01050 Uncharacterized protein family UPF0031 signature 2. 282458000075 PS01049 Uncharacterized protein family UPF0031 signature 1. 282458000076 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 282458000077 active sites [active] 282458000078 tetramer interface [polypeptide binding]; other site 282458000079 Pfam match to entry PF00221 PAL, Phenylalanine and histidine ammonia-lyase, score 713.20, E-value 2.5e-221 282458000080 PS00488 Phenylalanine and histidine ammonia-lyases signature. 282458000081 seryl-tRNA synthetase; Provisional; Region: PRK05431 282458000082 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 282458000083 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 282458000084 dimer interface [polypeptide binding]; other site 282458000085 active site 282458000086 motif 1; other site 282458000087 motif 2; other site 282458000088 motif 3; other site 282458000089 Pfam match to entry PF02403 Seryl_tRNA_N, Seryl-tRNA synthetase N-terminal domain, score 79.50, E-value 6.7e-20 282458000090 Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T), score 310.40, E-value 2.1e-89 282458000091 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 282458000092 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 282458000093 7 probable transmembrane helices predicted for SAR0010 by TMHMM2.0 at aa 15-32, 37-59, 63-85, 134-156, 161-183, 190-208 and 212-229 282458000094 Signal peptide predicted for SAR0011 by SignalP 2.0 HMM (Signal peptide probabilty 0.880) with cleavage site probability 0.549 between residues 34 and 35; signal peptide 282458000095 Predicted membrane protein [Function unknown]; Region: COG4392 282458000096 4 probable transmembrane helices predicted for SAR0011 by TMHMM2.0 at aa 7-29, 39-58, 70-87 and 91-108 282458000097 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 282458000098 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 282458000099 Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold, score 35.80, E-value 1e-06 282458000100 Predicted membrane protein [Function unknown]; Region: COG4241 282458000101 7 probable transmembrane helices predicted for SAR0013 by TMHMM2.0 at aa 39-61, 76-107, 120-142, 188-210, 223-245, 255-277 and 290-312 282458000102 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 282458000103 Signal peptide predicted for SAR0014 by SignalP 2.0 HMM (Signal peptide probabilty 0.958) with cleavage site probability 0.498 between residues 39 and 40; signal peptide 282458000104 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 282458000105 DHH family; Region: DHH; pfam01368 282458000106 DHHA1 domain; Region: DHHA1; pfam02272 282458000107 2 probable transmembrane helices predicted for SAR0014 by TMHMM2.0 at aa 9-31 and 35-54 282458000108 Pfam match to entry PF01368 DHH, DHH family, score 89.20, E-value 8.1e-23 282458000109 Pfam match to entry PF02272 DHHA1, DHHA1 domain, score 28.20, E-value 0.00019 282458000110 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 282458000111 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 282458000112 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 282458000113 Pfam match to entry PF01281 Ribosomal_L9, Ribosomal protein L9, score 210.90, E-value 2e-59 282458000114 PS00651 Ribosomal protein L9 signature. 282458000115 replicative DNA helicase; Region: DnaB; TIGR00665 282458000116 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 282458000117 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 282458000118 Walker A motif; other site 282458000119 ATP binding site [chemical binding]; other site 282458000120 Walker B motif; other site 282458000121 DNA binding loops [nucleotide binding] 282458000122 Pfam match to entry PF00772 DnaB, DnaB-like helicase, score 563.60, E-value 1.5e-177 282458000123 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000124 Predicted helix-turn-helix motif with score 1117 (+2.99 SD) at aa 346-367, sequence RTLKALARELECPVIALSQLSR 282458000125 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 282458000126 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 282458000127 GDP-binding site [chemical binding]; other site 282458000128 ACT binding site; other site 282458000129 IMP binding site; other site 282458000130 Pfam match to entry PF00709 Adenylsucc_synt, Adenylosuccinate synthetase, score 837.80, E-value 3.7e-248 282458000131 PS01266 Adenylosuccinate synthetase GTP-binding site. 282458000132 PS00513 Adenylosuccinate synthetase active site. 282458000133 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282458000134 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282458000135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458000136 active site 282458000137 phosphorylation site [posttranslational modification] 282458000138 intermolecular recognition site; other site 282458000139 dimerization interface [polypeptide binding]; other site 282458000140 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282458000141 DNA binding site [nucleotide binding] 282458000142 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 130.70, E-value 2.6e-35 282458000143 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 117.90, E-value 5.4e-34 282458000144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 282458000145 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 282458000146 dimerization interface [polypeptide binding]; other site 282458000147 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 282458000148 putative active site [active] 282458000149 heme pocket [chemical binding]; other site 282458000150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282458000151 dimer interface [polypeptide binding]; other site 282458000152 phosphorylation site [posttranslational modification] 282458000153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458000154 ATP binding site [chemical binding]; other site 282458000155 Mg2+ binding site [ion binding]; other site 282458000156 G-X-G motif; other site 282458000157 2 probable transmembrane helices predicted for SAR0019 by TMHMM2.0 at aa 15-37 and 183-205 282458000158 Pfam match to entry PF00672 HAMP, HAMP domain, score 66.10, E-value 7.3e-16 282458000159 Pfam match to entry PF00989 PAS, PAS domain, score 37.90, E-value 6.9e-09 282458000160 Pfam match to entry PF00512 signal, His Kinase A (phosphoacceptor) domain, score 91.10, E-value 2.3e-23 282458000161 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 156.60, E-value 4.2e-43 282458000162 Signal peptide predicted for SAR0020 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.846 between residues 36 and 37; signal peptide 282458000163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 282458000164 YycH protein; Region: YycH; pfam07435 282458000165 1 probable transmembrane helix predicted for SAR0020 by TMHMM2.0 at aa 7-29 282458000166 YycH protein; Region: YycI; cl02015 282458000167 Signal peptide predicted for SAR0021 by SignalP 2.0 HMM (Signal peptide probabilty 0.852) with cleavage site probability 0.828 between residues 31 and 32; signal peptide 282458000168 1 probable transmembrane helix predicted for SAR0021 by TMHMM2.0 at aa 9-26 282458000169 Signal peptide predicted for SAR0022 by SignalP 2.0 HMM (Signal peptide probabilty 0.600) with cleavage site probability 0.235 between residues 23 and 24; signal peptide 282458000170 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 282458000171 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 14.50, E-value 0.00016 282458000172 Signal peptide predicted for SAR0023 by SignalP 2.0 HMM (Signal peptide probabilty 0.705) with cleavage site probability 0.225 between residues 43 and 44; signal peptide 282458000173 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 282458000174 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 282458000175 putative active site [active] 282458000176 putative metal binding site [ion binding]; other site 282458000177 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 282458000178 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 282458000179 1 probable transmembrane helix predicted for SAR0023 by TMHMM2.0 at aa 17-39 282458000180 Pfam match to entry PF01009 5_nucleotidase, 5'-nucleotidase, catalytic domain, score 196.10, E-value 1.3e-56 282458000181 PS00786 5'-nucleotidase signature 2. 282458000182 Pfam match to entry PF02872 5_nucleotidaseC, 5'-nucleotidase, C-terminal domain, score 261.10, E-value 1.5e-74 282458000183 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282458000184 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 282458000185 Pfam match to entry PF02590 DUF163, Uncharacterized ACR, COG1576, score 259.60, E-value 4.3e-74 282458000186 Staphylococcal cassette chromosome mec (SCCmec) 282458000187 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 282458000188 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 282458000189 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 282458000190 Insertion sequence IS431 282458000191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 282458000192 Integrase core domain; Region: rve; pfam00665 282458000193 Pfam match to entry PF00665 rve, Integrase core domain, score 66.80, E-value 3.9e-18 282458000194 Predicted helix-turn-helix motif with score 980 (+2.52 SD) at aa 31-52, sequence ISEILRERGVNVHHSTVYRWVQ 282458000195 Similar to several proteins involved in Gram positive plasmid replication. Similar to Staphylococcus cohnii and unidentified sp plasmid replication protein RepB TR:Q51988 (EMBL:U32369) (334 aa) fasta scores: E(): 2e-127, 99.701% id in 334 aa. C-terminal region is similar to Staphylococcus aureus, and Bacillus sp plasmid replication protein RepB SW:REPB_STAAU (P05061) (235 aa) fasta scores: E(): 3.2e-86, 99.574% id in 235 aa. Possible alternative translational start sites. Contains a nonsense mutation (ochre) after codon 264;replication protein (pseudogene) 282458000196 Pfam match to entry PF01446 Rep, Replication protein, score 126.50, E-value 5.8e-35 282458000197 Pfam match to entry PF01446 Rep, Replication protein, score 346.80, E-value 2.4e-100 282458000198 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 282458000199 Pfam match to entry PF01076 Mob_Pre, Plasmid recombination enzyme, score 364.10, E-value 1.4e-105 282458000200 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 282458000201 dimer interface [polypeptide binding]; other site 282458000202 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 282458000203 ligand binding site [chemical binding]; other site 282458000204 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 72.90, E-value 8.5e-20 282458000205 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cd05397 282458000206 metal binding triad [ion binding]; metal-binding site 282458000207 KNTase C-terminal domain; Region: KNTase_C; pfam07827 282458000208 Pfam match to entry PF02314 KNTase, Kanamycin nucleotidyltransferase, score 818.70, E-value 2.1e-242 282458000209 Insertion sequence IS431 282458000210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 282458000211 Integrase core domain; Region: rve; pfam00665 282458000212 Pfam match to entry PF00665 rve, Integrase core domain, score 66.80, E-value 3.9e-18 282458000213 Predicted helix-turn-helix motif with score 980 (+2.52 SD) at aa 31-52, sequence ISEILRERGVNVHHSTVYRWVQ 282458000214 Similar to the C-terminal region of Staphylococcus aureus HMG-CoA synthase MvaS TR:Q9FD87 (EMBL:AF290086) (388 aa) fasta scores: E(): 8.7e-05, 43.137% id in 51 aa. Previously sequenced as Staphylococcus aureus hypothetical protein TR:BAB47630 (EMBL:AB037671) (55 aa) fasta scores: E(): 2e-21, 100.000% id in 55 aa. Similarity with the HMG-CoA synthase MvaS extends beyond the translational start to the upstream IS element. Probable gene remnant;HMG-CoA synthase (fragment) 282458000215 1 probable transmembrane helix predicted for SAR0036 by TMHMM2.0 at aa 39-58 282458000216 Imperfect repeat, gataagaggtaagttaaaagcagttctaagtaaaattgca x8 282458000217 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 282458000218 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 282458000219 putative active site [active] 282458000220 catalytic site [active] 282458000221 putative metal binding site [ion binding]; other site 282458000222 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 282458000223 putative active site [active] 282458000224 putative catalytic site [active] 282458000225 Pfam match to entry PF01575 MaoC_dehydratas, MaoC like domain, score 146.00, E-value 6.8e-40 282458000226 Signal peptide predicted for SAR0039 by SignalP 2.0 HMM (Signal peptide probabilty 0.965) with cleavage site probability 0.754 between residues 24 and 25; signal peptide 282458000227 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 282458000228 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 282458000229 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 282458000230 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 282458000231 Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain, score 380.90, E-value 1.3e-110 282458000232 1 probable transmembrane helix predicted for SAR0039 by TMHMM2.0 at aa 7-24 282458000233 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 282458000234 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 282458000235 4 probable transmembrane helices predicted for SAR0040 by TMHMM2.0 at aa 5-27, 40-62, 103-125 and 316-338 282458000236 Predicted transcriptional regulator [Transcription]; Region: COG3682 282458000237 Similar to Staphylococcus xylosus xylose repressor XylR SW:XYLR_STAXY (P27159) (383 aa) fasta scores: E(): 2.5e-86, 63.708% id in 383 aa, and to Staphylococcus aureus xylose repressor XylR TR:BAB47619 (EMBL:AB037671) (382 aa) fasta scores: E(): 1.1e-132, 99.215% id in 382 aa. CDS contains a possible frameshift after codon 4. Possible alternative translational start sites downstream of this, therefore the effect on the function of this CDS is not known;xylose repressor (pseudogene) 282458000238 Predicted helix-turn-helix motif with score 1609 (+4.67 SD) at aa 11-32, sequence ISRTQISKNLEINKATISSILN 282458000239 Pfam match to entry PF00480 ROK, ROK family, score 170.40, E-value 1.3e-49 282458000240 PS01125 ROK family signature. 282458000241 Similar to Staphylococcus aureus hypothetical protein TR:Q9S0L8 (EMBL:AB033763) (442 aa) fasta scores: E(): 4.4e-132, 70.159% id in 439 aa, and to Deinococcus radiodurans conserved hypothetical protein DRA0304 TR:Q9RYK8 (EMBL:AE001863) (483 aa) fasta scores: E(): 4.6e-45, 37.773% id in 458 aa. Contains a nonsense mutation (ochre) after codon 312;metallo-beta-lactamase superfamily protein (pseudogene) 282458000242 Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain, score 28.50, E-value 0.00015 282458000243 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 79.30, E-value 8.2e-20 282458000244 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 282458000245 active site residue [active] 282458000246 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 282458000247 CPxP motif; other site 282458000248 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 282458000249 Pfam match to entry PF01206 UPF0033, Uncharacterized protein family UPF0033, score 34.00, E-value 3.5e-06 282458000250 Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain, score 40.50, E-value 3.8e-08 282458000251 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 282458000252 putative homodimer interface [polypeptide binding]; other site 282458000253 putative homotetramer interface [polypeptide binding]; other site 282458000254 putative metal binding site [ion binding]; other site 282458000255 putative homodimer-homodimer interface [polypeptide binding]; other site 282458000256 putative allosteric switch controlling residues; other site 282458000257 Pfam match to entry PF02583 DUF156, Uncharacterized BCR, COG1937, score 60.00, E-value 5e-14 282458000258 Previously sequenced as Staphylococcus aureus hypothetical protein TR:BAB47613 (EMBL:AB037671) (214 aa) fasta scores: E(): 1.2e-68, 100.000% id in 214 aa. Similar to Bacillus subtilis hypothetical protein YrkJ SW:YRKJ_BACSU (P54437) (261 aa) fasta scores: E(): 4.4e-26, 41.364% id in 220 aa. CDS is truncated at the C-terminus in comparison to the B. subtilis protein. Probable gene remnant; membrane protein (fragment) 282458000259 Signal peptide predicted for SAR0048 by SignalP 2.0 HMM (Signal peptide probabilty 0.858) with cleavage site probability 0.548 between residues 48 and 49 282458000260 6 probable transmembrane helices predicted for SAR0048 by TMHMM2.0 at aa 10-32, 34-56, 81-103, 108-125, 140-171 and 178-196 282458000261 Pfam match to entry PF01925 DUF81, Domain of unknown function DUF81, score 55.30, E-value 1.2e-14 282458000262 Transposon Tn554 282458000263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458000264 S-adenosylmethionine binding site [chemical binding]; other site 282458000265 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 282458000266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458000267 S-adenosylmethionine binding site [chemical binding]; other site 282458000268 Pfam match to entry PF00398 RrnaAD, Ribosomal RNA adenine dimethylases, score 425.90, E-value 9.3e-132 282458000269 PS01131 Ribosomal RNA adenine dimethylases signature. 282458000270 aminoglycoside resistance protein; Provisional; Region: PRK13746 282458000271 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 282458000272 active site 282458000273 NTP binding site [chemical binding]; other site 282458000274 metal binding triad [ion binding]; metal-binding site 282458000275 antibiotic binding site [chemical binding]; other site 282458000276 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 282458000277 Pfam match to entry PF01909 NTP_transf_2, Nucleotidyltransferase domain, score 82.10, E-value 1.2e-20 282458000278 Predicted helix-turn-helix motif with score 1150 (+3.10 SD) at aa 40-61, sequence INFNSIAKEANVSKSWLYKEHD 282458000279 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 282458000280 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 282458000281 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 282458000282 Int/Topo IB signature motif; other site 282458000283 PS00018 EF-hand calcium-binding domain. 282458000284 Pfam match to entry PF00589 Phage_integrase, Phage integrase, score 152.60, E-value 7e-42 282458000285 Pfam match to entry PF02899 Phage_integr_N, Phage integrase, N-terminal SAM-like domain, score 3.10, E-value 0.29 282458000286 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 282458000287 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 282458000288 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 282458000289 Int/Topo IB signature motif; other site 282458000290 Pfam match to entry PF00589 Phage_integrase, Phage integrase, score 196.40, E-value 4.4e-55 282458000291 Pfam match to entry PF02899 Phage_integr_N, Phage integrase, N-terminal SAM-like domain, score 25.40, E-value 0.0014 282458000292 Similar to an internal region of Bacillus subtilis probable DNA repair protein RadC SW:RADC_BACSU (Q02170) (231 aa) fasta scores: E(): 5e-09, 41.558% id in 77 aa. Previously sequenced as Staphylococcus aureus truncated DNA repair protein RadC homologue Orf N044 TR:Q9XB90 (EMBL:D86934) (105 aa) fasta scores: E(): 2.8e-40, 100.000% id in 105 aa. Possible gene remnant;DNA repair protein RadC (fragment) 282458000293 PS01302 DNA repair protein radC family signature. 282458000294 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 282458000295 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 282458000296 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 282458000297 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 282458000298 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 282458000299 catalytic residues [active] 282458000300 catalytic nucleophile [active] 282458000301 Presynaptic Site I dimer interface [polypeptide binding]; other site 282458000302 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 282458000303 Synaptic Flat tetramer interface [polypeptide binding]; other site 282458000304 Synaptic Site I dimer interface [polypeptide binding]; other site 282458000305 DNA binding site [nucleotide binding] 282458000306 Recombinase; Region: Recombinase; pfam07508 282458000307 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 282458000308 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 282458000309 Pfam match to entry PF00239 resolvase, Resolvase class of site-specific recombinases, score 114.80, E-value 2.2e-33 282458000310 PS00397 Site-specific recombinases active site. 282458000311 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 282458000312 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 282458000313 catalytic residues [active] 282458000314 catalytic nucleophile [active] 282458000315 Recombinase; Region: Recombinase; pfam07508 282458000316 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 282458000317 Pfam match to entry PF00239 resolvase, Resolvase class of site-specific recombinases, score 43.30, E-value 6.2e-12 282458000318 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 282458000319 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000320 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 282458000321 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000322 Similar to Bacillus anthracis plasmid IS150-like transposase TR:Q57057 (EMBL:U30715) (274 aa) fasta scores: E(): 2.9e-43, 48.905% id in 274 aa, and to Bacillus thuringiensis transposase TR:P94597 (EMBL:Y09946) (301 aa) fasta scores: E(): 1.8e-26, 38.028% id in 284 aa. Contains a nonsense mutation (ochre) after codon 117; transposase (pseudogene) 282458000323 Pfam match to entry PF00665 rve, Integrase core domain, score 76.80, E-value 5.1e-21 282458000324 Predicted helix-turn-helix motif with score 1379 (+3.88 SD) at aa 17-38, sequence YSIKLILEVLNIPKSTYYRWKN 282458000325 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 282458000326 Homeodomain-like domain; Region: HTH_23; cl17451 282458000327 Similar to the C-terminal regions of Haemophilus influenzae hypothetical protein Hi0594 SW:YFCC_HAEIN (P44023) (509 aa) fasta scores: E(): 5.7e-62, 58.140% id in 301 aa, and to Borrelia burgdorferi conserved hypothetical integral membrane protein BB0843 TR:O51783 (EMBL:AE001183) (482 aa) fasta scores: E(): 8.2e-31, 37.785% id in 307 aa. C-terminal region is identical to Staphylococcus aureus hypothetical protein Orf N024 TR:Q9KX85 (EMBL:D86934) (185 aa) fasta scores: E(): 1.4e-62, 100.000% id in 185 aa. Similar to the C-terminal regions of SAR1144, 94.333% identity (94.333% ungapped) in 300 aa overlap. Probable gene remnant; membrane protein (fragment) 282458000328 8 probable transmembrane helices predicted for SAR0067 by TMHMM2.0 at aa 27-49, 91-113, 117-139, 146-168, 188-210, 217-239, 249-271 and 276-298 282458000329 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282458000330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458000331 active site 282458000332 phosphorylation site [posttranslational modification] 282458000333 intermolecular recognition site; other site 282458000334 dimerization interface [polypeptide binding]; other site 282458000335 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282458000336 DNA binding site [nucleotide binding] 282458000337 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 45.20, E-value 3.8e-12 282458000338 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 124.50, E-value 2e-33 282458000339 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 282458000340 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 282458000341 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 282458000342 Ligand Binding Site [chemical binding]; other site 282458000343 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 282458000344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282458000345 dimer interface [polypeptide binding]; other site 282458000346 phosphorylation site [posttranslational modification] 282458000347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458000348 ATP binding site [chemical binding]; other site 282458000349 Mg2+ binding site [ion binding]; other site 282458000350 G-X-G motif; other site 282458000351 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 112.30, E-value 9e-30 282458000352 Pfam match to entry PF00512 signal, His Kinase A (phosphoacceptor) domain, score 67.70, E-value 2.5e-16 282458000353 4 probable transmembrane helices predicted for SAR0069 by TMHMM2.0 at aa 402-419, 426-443, 447-464 and 476-495 282458000354 Pfam match to entry PF02702 KdpD, Osmosensitive K+ channel His kinase sensor domain, score 244.30, E-value 1.7e-69 282458000355 Signal peptide predicted for SAR0070 by SignalP 2.0 HMM (Signal peptide probabilty 0.652) with cleavage site probability 0.225 between residues 27 and 28; signal peptide 282458000356 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 282458000357 12 probable transmembrane helices predicted for SAR0070 by TMHMM2.0 at aa 4-26, 63-85, 127-149, 169-186, 248-270, 282-304, 324-346, 353-372, 382-404, 417-439, 485-507 and 520-542 282458000358 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 282458000359 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 282458000360 Soluble P-type ATPase [General function prediction only]; Region: COG4087 282458000361 7 probable transmembrane helices predicted for SAR0071 by TMHMM2.0 at aa 28-50, 60-82, 217-239, 249-271, 571-593, 608-627 and 648-670 282458000362 Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 ATPase, score 189.80, E-value 1.4e-56 282458000363 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 105.90, E-value 7.6e-28 282458000364 PS00154 E1-E2 ATPases phosphorylation site. 282458000365 Similar to Clostridium acetobutylicum potassium-transporting ATPase C chain KdpC SW:ATKC_CLOAB (P94606) (204 aa) fasta scores: E(): 9.4e-17, 37.245% id in 196 aa. Previously sequenced as Staphylococcus aureus potassium-transporting ATPase C chain KdpC SW:ATKC_STAAU (Q9LC48) (185 aa) fasta scores: E(): 6.2e-62, 97.297% id in 185 aa. Contains a frameshift after codon 120;potassium-transporting ATPase C chain (pseudogene) 282458000366 Pfam match to entry PF02669 KdpC, K+-transporting ATPase, c chain, score 20.90, E-value 3.7e-08 282458000367 Signal peptide predicted for SAR0072 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.394 between residues 30 and 31 282458000368 1 probable transmembrane helix predicted for SAR0072 by TMHMM2.0 at aa 7-29 282458000369 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000370 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 282458000371 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000372 1 probable transmembrane helix predicted for SAR0077 by TMHMM2.0 at aa 42-64 282458000373 Protein kinase domain; Region: Pkinase; pfam00069 282458000374 Catalytic domain of Protein Kinases; Region: PKc; cd00180 282458000375 active site 282458000376 ATP binding site [chemical binding]; other site 282458000377 substrate binding site [chemical binding]; other site 282458000378 activation loop (A-loop); other site 282458000379 Pfam match to entry PF00069 pkinase, Protein kinase domain, score 51.00, E-value 4.7e-13 282458000380 AAA domain; Region: AAA_13; pfam13166 282458000381 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 282458000383 Transposase; Region: HTH_Tnp_1; pfam01527 282458000384 Pfam match to entry PF01527 Transposase_8, Transposase, score 83.20, E-value 5.3e-21 282458000385 Predicted helix-turn-helix motif with score 1264 (+3.49 SD) at aa 30-51, sequence KPRNEIIREYDLTPSPLGKWIK 282458000386 putative transposase OrfB; Reviewed; Region: PHA02517 282458000387 HTH-like domain; Region: HTH_21; pfam13276 282458000388 Integrase core domain; Region: rve; pfam00665 282458000389 Integrase core domain; Region: rve_3; pfam13683 282458000390 Pfam match to entry PF00665 rve, Integrase core domain, score 140.10, E-value 2.7e-39 282458000391 Poor database matches. Similar to C-terminus of Staphylococcus aureus hypothetical protein TR:Q9XBB4 (EMBL:D86934) (502 aa) fasta scores: E(): 1.8e-06, 50.000% id in 52 aa. Similar to C-terminus of SAR0079, 50.000% identity (50.000% ungapped) in 52 aa overlap. Possible gene remnant;hypothetical protein (fragment) 282458000392 Insertion sequence ISX 282458000393 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 282458000394 Helix-turn-helix domain; Region: HTH_38; pfam13936 282458000395 Integrase core domain; Region: rve; pfam00665 282458000396 Pfam match to entry PF00665 rve, Integrase core domain, score 119.70, E-value 2.1e-33 282458000397 PS01043 Transposases, IS30 family, signature. 282458000398 Predicted helix-turn-helix motif with score 1647 (+4.80 SD) at aa 22-43, sequence YSLRSIARKLKRSVSTISREIS 282458000399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458000400 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 282458000401 Walker A motif; other site 282458000402 ATP binding site [chemical binding]; other site 282458000403 Walker B motif; other site 282458000404 arginine finger; other site 282458000405 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000406 5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736 282458000407 transposase; Provisional; Region: PRK06526 282458000408 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 282458000409 active site 282458000410 3 probable transmembrane helices predicted for SAR0093 by TMHMM2.0 at aa 46-63, 70-87 and 102-119 282458000411 Signal peptide predicted for SAR0094 by SignalP 2.0 HMM (Signal peptide probabilty 0.919) with cleavage site probability 0.318 between residues 38 and 39; signal peptide 282458000412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458000413 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282458000414 putative substrate translocation pore; other site 282458000415 14 probable transmembrane helices predicted for SAR0094 by TMHMM2.0 at aa 7-29, 44-66, 73-95, 105-123, 135-157, 162-184, 197-219, 223-240, 261-283, 298-315, 322-344, 354-376, 397-414 and 429-451 282458000416 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -135.00, E-value 0.055 282458000417 Similar to Bacillus subtilis hypothetical protein YvcN SW:YVCN_BACSU (O06977) (254 aa) fasta scores: E(): 6.8e-05, 22.500% id in 240 aa, and to Rhizobium loti N-hydroxyarylamine O-acetyltransferase MLL5814 TR:BAB52196 (EMBL:AP003007) (270 aa) fasta scores: E(): 0.002, 20.623% id in 257 aa. Contains nonsense and frameshift mutations; acetyltransferase (pseudogene) 282458000418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 282458000419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 282458000420 Pfam match to entry PF02796 HTH_7, Helix-turn-helix domain of resolvase, score 21.90, E-value 0.00041 282458000421 Predicted helix-turn-helix motif with score 1706 (+5.00 SD) at aa 36-57, sequence KKMSDIAKISGVGVGTLYRHFE 282458000422 Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 32.40, E-value 1.1e-06 282458000423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458000424 Coenzyme A binding pocket [chemical binding]; other site 282458000425 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 50.00, E-value 5.2e-11 282458000426 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 282458000427 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 282458000428 FMN binding site [chemical binding]; other site 282458000429 active site 282458000430 catalytic residues [active] 282458000431 substrate binding site [chemical binding]; other site 282458000432 Pfam match to entry PF01207 UPF0034, Uncharacterized protein family UPF0034, score 123.10, E-value 5.3e-33 282458000433 PS01136 Uncharacterized protein family UPF0034 signature. 282458000434 2 probable transmembrane helices predicted for SAR0100 by TMHMM2.0 at aa 4-21 and 23-45 282458000435 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 282458000436 5 probable transmembrane helices predicted for SAR0102 by TMHMM2.0 at aa 4-26, 55-77, 87-109, 121-143 and 163-182 282458000437 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 282458000438 Part of AAA domain; Region: AAA_19; pfam13245 282458000439 AAA domain; Region: AAA_12; pfam13087 282458000440 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000441 4 probable transmembrane helices predicted for SAR0104 by TMHMM2.0 at aa 33-55, 59-81, 102-124 and 139-156 282458000442 Signal peptide predicted for SAR0105 by SignalP 2.0 HMM (Signal peptide probabilty 0.971) with cleavage site probability 0.706 between residues 26 and 27; signal peptide 282458000443 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 282458000444 active site 282458000445 catalytic site [active] 282458000446 putative metal binding site [ion binding]; other site 282458000447 1 probable transmembrane helix predicted for SAR0105 by TMHMM2.0 at aa 7-24 282458000448 Pfam match to entry PF00388 PI-PLC-X, Phosphatidylinositol-specific phospholipase C, X domain, score 236.10, E-value 5e-67 282458000449 Signal peptide predicted for SAR0106 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.397 between residues 30 and 31; signal peptide 282458000450 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282458000451 1 probable transmembrane helix predicted for SAR0106 by TMHMM2.0 at aa 5-27 282458000452 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458000453 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 282458000454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 282458000455 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 282458000456 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 99.10, E-value 8.4e-26 282458000457 Predicted helix-turn-helix motif with score 1860 (+5.52 SD) at aa 172-193, sequence LSLSELSEYVGWSESHLSKKFA 282458000458 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 282458000459 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 282458000460 metal binding site [ion binding]; metal-binding site 282458000461 dimer interface [polypeptide binding]; other site 282458000462 Pfam match to entry PF01546 Peptidase_M20, Peptidase M20/M25/M40, score 164.40, E-value 3.2e-46 282458000463 Signal peptide predicted for SAR0109 by SignalP 2.0 HMM (Signal peptide probabilty 0.950) with cleavage site probability 0.596 between residues 41 and 42; signal peptide 282458000464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458000465 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282458000466 putative substrate translocation pore; other site 282458000467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458000468 14 probable transmembrane helices predicted for SAR0109 by TMHMM2.0 at aa 7-26, 46-68, 80-102, 106-123, 136-158, 162-181, 201-223, 227-246, 267-289, 295-317, 330-349, 353-375, 403-425 and 430-452 282458000469 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -130.40, E-value 0.038 282458000470 PS00079 Multicopper oxidases signature 1. 282458000471 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 282458000472 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 282458000473 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 282458000474 PhoU domain; Region: PhoU; pfam01895 282458000475 Pfam match to entry PF02690 Na_Pi_cotrans, Na+/Pi-cotransporter, score 116.60, E-value 4.6e-31 282458000476 9 probable transmembrane helices predicted for SAR0110 by TMHMM2.0 at aa 5-27, 53-75, 88-107, 112-127, 134-156, 176-198, 210-232, 247-269 and 289-311 282458000477 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 282458000478 Signal peptide predicted for SAR0112 by SignalP 2.0 HMM (Signal peptide probabilty 0.971) with cleavage site probability 0.606 between residues 27 and 28; signal peptide 282458000479 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 282458000480 4 probable transmembrane helices predicted for SAR0112 by TMHMM2.0 at aa 7-26, 51-73, 94-116 and 126-148 282458000481 Signal peptide predicted for SAR0113 by SignalP 2.0 HMM (Signal peptide probabilty 0.808) with cleavage site probability 0.669 between residues 40 and 41; signal peptide 282458000482 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 282458000483 L-lactate permease; Region: Lactate_perm; cl00701 282458000484 13 probable transmembrane helices predicted for SAR0113 by TMHMM2.0 at aa 12-34, 38-60, 67-89, 127-149, 156-178, 193-215, 224-246, 250-267, 293-315, 348-370, 391-413, 423-445 and 512-529 282458000485 Pfam match to entry PF02652 Lactate_perm, L-lactate permease, score 666.20, E-value 1.6e-196 282458000486 PS00904 Protein prenyltransferases alpha subunit repeat signature. 282458000487 Signal peptide predicted for SAR0114 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.783 between residues 36 and 37; signal peptide 282458000488 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282458000489 B domain; Region: B; pfam02216 282458000490 B domain; Region: B; pfam02216 282458000491 B domain; Region: B; pfam02216 282458000492 B domain; Region: B; pfam02216 282458000493 B domain; Region: B; pfam02216 282458000494 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282458000495 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 52.10, E-value 1.3e-11 282458000496 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282458000497 Pfam match to entry PF01476 LysM, LysM domain, score 58.40, E-value 1.6e-13 282458000498 Pfam match to entry PF02216 B, B domain, score 120.30, E-value 3.6e-32 282458000499 Pfam match to entry PF02216 B, B domain, score 124.80, E-value 1.6e-33 282458000500 Pfam match to entry PF02216 B, B domain, score 123.50, E-value 3.8e-33 282458000501 Pfam match to entry PF02216 B, B domain, score 127.80, E-value 2e-34 282458000502 Pfam match to entry PF02216 B, B domain, score 124.10, E-value 2.6e-33 282458000503 1 probable transmembrane helix predicted for SAR0114 by TMHMM2.0 at aa 12-34 282458000504 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282458000505 Transcriptional regulators [Transcription]; Region: MarR; COG1846 282458000506 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282458000507 Transcriptional regulators [Transcription]; Region: MarR; COG1846 282458000508 Signal peptide predicted for SAR0116 by SignalP 2.0 HMM (Signal peptide probabilty 0.899) with cleavage site probability 0.581 between residues 32 and 33; signal peptide 282458000509 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 282458000510 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282458000511 ABC-ATPase subunit interface; other site 282458000512 dimer interface [polypeptide binding]; other site 282458000513 putative PBP binding regions; other site 282458000514 9 probable transmembrane helices predicted for SAR0116 by TMHMM2.0 at aa 13-35, 59-81, 94-111, 115-137, 149-171, 196-213, 244-266, 281-303 and 310-329 282458000515 Pfam match to entry PF01032 FecCD_family, FecCD transport family, score 269.80, E-value 3.7e-77 282458000516 Signal peptide predicted for SAR0117 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.500 between residues 31 and 32; signal peptide 282458000517 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 282458000518 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282458000519 ABC-ATPase subunit interface; other site 282458000520 dimer interface [polypeptide binding]; other site 282458000521 putative PBP binding regions; other site 282458000522 Pfam match to entry PF01032 FecCD_family, FecCD transport family, score 340.80, E-value 1.6e-98 282458000523 9 probable transmembrane helices predicted for SAR0117 by TMHMM2.0 at aa 10-32, 62-81, 91-109, 116-138, 148-170, 195-217, 237-259, 279-301 and 306-323 282458000524 Signal peptide predicted for SAR0118 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.559 between residues 27 and 28; signal peptide 282458000525 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 282458000526 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 282458000527 siderophore binding site; other site 282458000528 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 176.60, E-value 4e-49 282458000529 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458000530 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 282458000531 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 282458000532 dimer interface [polypeptide binding]; other site 282458000533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458000534 catalytic residue [active] 282458000535 Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme, score 273.70, E-value 2.5e-78 282458000536 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 282458000537 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 282458000538 Pfam match to entry PF02423 ODC_Mu_crystall, Ornithine cyclodeaminase/mu-crystallin family, score 176.30, E-value 5.1e-49 282458000539 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 282458000540 IucA / IucC family; Region: IucA_IucC; pfam04183 282458000541 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 282458000542 Signal peptide predicted for SAR0122 by SignalP 2.0 HMM (Signal peptide probabilty 0.803) with cleavage site probability 0.509 between residues 56 and 57; signal peptide 282458000543 drug efflux system protein MdtG; Provisional; Region: PRK09874 282458000544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458000545 putative substrate translocation pore; other site 282458000546 10 probable transmembrane helices predicted for SAR0122 by TMHMM2.0 at aa 13-35, 50-72, 85-107, 164-186, 222-244, 259-276, 288-307, 317-339, 346-368 and 378-397 282458000547 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -82.40, E-value 0.00076 282458000548 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 282458000549 IucA / IucC family; Region: IucA_IucC; pfam04183 282458000550 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 282458000551 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 282458000552 IucA / IucC family; Region: IucA_IucC; pfam04183 282458000553 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 282458000554 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 282458000555 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 282458000556 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 282458000557 dimer interface [polypeptide binding]; other site 282458000558 active site 282458000559 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 282458000560 catalytic residues [active] 282458000561 substrate binding site [chemical binding]; other site 282458000562 Pfam match to entry PF02784 Orn_Arg_deC_N, Pyridoxal-dependent decarboxylase, pyridoxal binding domain, score 78.60, E-value 2.1e-22 282458000563 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 282458000564 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 282458000565 ParB-like nuclease domain; Region: ParBc; pfam02195 282458000566 3 probable transmembrane helices predicted for SAR0128 by TMHMM2.0 at aa 20-42, 57-79 and 92-114 282458000567 acetoin reductase; Validated; Region: PRK08643 282458000568 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 282458000569 NAD binding site [chemical binding]; other site 282458000570 homotetramer interface [polypeptide binding]; other site 282458000571 homodimer interface [polypeptide binding]; other site 282458000572 active site 282458000573 substrate binding site [chemical binding]; other site 282458000574 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 281.00, E-value 1.5e-80 282458000575 PS00061 Short-chain dehydrogenases/reductases family signature. 282458000576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 282458000577 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 282458000578 NAD(P) binding site [chemical binding]; other site 282458000579 active site 282458000580 Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase, score 280.50, E-value 2.2e-80 282458000581 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 282458000582 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 282458000583 Pfam match to entry PF02397 Bact_transf, Bacterial sugar transferase, score 150.30, E-value 3.5e-41 282458000584 1 probable transmembrane helix predicted for SAR0131 by TMHMM2.0 at aa 49-71 282458000585 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 282458000586 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 282458000587 putative ADP-binding pocket [chemical binding]; other site 282458000588 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 112.80, E-value 3.6e-30 282458000589 Signal peptide predicted for SAR0133 by SignalP 2.0 HMM (Signal peptide probabilty 0.952) with cleavage site probability 0.702 between residues 28 and 29; signal peptide 282458000590 12 probable transmembrane helices predicted for SAR0133 by TMHMM2.0 at aa 9-28, 32-54, 59-81, 91-113, 120-142, 166-188, 195-217, 232-254, 290-312, 332-354, 361-383 and 388-402 282458000591 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 282458000592 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 282458000593 Pfam match to entry PF01943 Polysacc_synt, Polysaccharide biosynthesis protein, score 117.70, E-value 2.2e-31 282458000594 13 probable transmembrane helices predicted for SAR0134 by TMHMM2.0 at aa 43-65, 86-108, 113-135, 142-161, 171-190, 221-243, 247-266, 292-314, 319-341, 354-376, 380-399, 408-430 and 434-456 282458000595 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 282458000596 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 282458000597 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 282458000598 Pfam match to entry PF00081 sodfe, Iron/manganese superoxide dismutases, alpha-hairpin domain, score 173.70, E-value 2.5e-51 282458000599 Pfam match to entry PF02777 sodfe_C, Iron/manganese superoxide dismutases, C-terminal domain, score 209.90, E-value 1.3e-63 282458000600 PS00088 Manganese and iron superoxide dismutases signature. 282458000601 Signal peptide predicted for SAR0136 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 28 and 29; signal peptide 282458000602 1 probable transmembrane helix predicted for SAR0136 by TMHMM2.0 at aa 192-214 282458000603 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 282458000604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 282458000605 DNA-binding site [nucleotide binding]; DNA binding site 282458000606 Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 76.00, E-value 6.2e-22 282458000607 PS00043 Bacterial regulatory proteins, gntR family signature. 282458000608 Predicted helix-turn-helix motif with score 1559 (+4.50 SD) at aa 31-52, sequence PTEKELCARFDVSRMTLRQAIK 282458000609 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 282458000610 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 282458000611 Pfam match to entry PF01048 PNP_UDP_1, Phosphorylase, score 295.70, E-value 5.7e-85 282458000612 PS01232 Purine and other phosphorylases family 1 signature. 282458000613 Signal peptide predicted for SAR0139 by SignalP 2.0 HMM (Signal peptide probabilty 0.973) with cleavage site probability 0.775 between residues 37 and 38; signal peptide 282458000614 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282458000615 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -114.50, E-value 0.01 282458000616 14 probable transmembrane helices predicted for SAR0139 by TMHMM2.0 at aa 12-34, 47-69, 76-98, 102-124, 136-158, 163-185, 198-215, 220-237, 258-280, 290-309, 321-340, 344-366, 379-401 and 421-443 282458000617 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 282458000618 intersubunit interface [polypeptide binding]; other site 282458000619 active site 282458000620 catalytic residue [active] 282458000621 Pfam match to entry PF01791 DeoC, Deoxyribose-phosphate aldolase, score 350.70, E-value 1.6e-101 282458000622 phosphopentomutase; Provisional; Region: PRK05362 282458000623 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 282458000624 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000625 Pfam match to entry PF01676 Metalloenzyme, Metalloenzyme superfamily, score 129.00, E-value 8.6e-35 282458000626 Signal peptide predicted for SAR0142 by SignalP 2.0 HMM (Signal peptide probabilty 0.924) with cleavage site probability 0.273 between residues 45 and 46; signal peptide 282458000627 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 282458000628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458000629 dimer interface [polypeptide binding]; other site 282458000630 conserved gate region; other site 282458000631 putative PBP binding loops; other site 282458000632 ABC-ATPase subunit interface; other site 282458000633 6 probable transmembrane helices predicted for SAR0142 by TMHMM2.0 at aa 23-45, 83-105, 117-139, 191-208, 215-237 and 247-266 282458000634 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 29.30, E-value 9.1e-05 282458000635 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 282458000636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458000637 dimer interface [polypeptide binding]; other site 282458000638 conserved gate region; other site 282458000639 ABC-ATPase subunit interface; other site 282458000640 6 probable transmembrane helices predicted for SAR0143 by TMHMM2.0 at aa 21-43, 83-105, 118-140, 145-164, 185-207 and 232-254 282458000641 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 27.40, E-value 0.00032 282458000642 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 282458000643 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 282458000644 Walker A/P-loop; other site 282458000645 ATP binding site [chemical binding]; other site 282458000646 Q-loop/lid; other site 282458000647 ABC transporter signature motif; other site 282458000648 Walker B; other site 282458000649 D-loop; other site 282458000650 H-loop/switch region; other site 282458000651 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 176.90, E-value 3.2e-49 282458000652 PS00211 ABC transporters family signature. 282458000653 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000654 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 282458000655 Signal peptide predicted for SAR0145 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.259 between residues 22 and 23; signal peptide 282458000656 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 282458000657 1 probable transmembrane helix predicted for SAR0145 by TMHMM2.0 at aa 7-26 282458000658 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458000659 Signal peptide predicted for SAR0146 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.609 between residues 27 and 28; signal peptide 282458000660 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 282458000661 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 282458000662 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 282458000663 active site 282458000664 metal binding site [ion binding]; metal-binding site 282458000665 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 282458000666 Pfam match to entry PF01009 5_nucleotidase, 5'-nucleotidase, catalytic domain, score 133.60, E-value 2.6e-38 282458000667 PS00786 5'-nucleotidase signature 2. 282458000668 Pfam match to entry PF02872 5_nucleotidaseC, 5'-nucleotidase, C-terminal domain, score 38.30, E-value 1.7e-07 282458000669 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 282458000670 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282458000671 non-specific DNA binding site [nucleotide binding]; other site 282458000672 salt bridge; other site 282458000673 sequence-specific DNA binding site [nucleotide binding]; other site 282458000674 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 282458000675 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 32.00, E-value 1.4e-05 282458000676 Predicted helix-turn-helix motif with score 1894 (+5.64 SD) at aa 16-37, sequence LSRKELSEKINVSEQAIWQYET 282458000677 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 282458000678 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 282458000679 putative catalytic cysteine [active] 282458000680 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 282458000681 putative active site [active] 282458000682 metal binding site [ion binding]; metal-binding site 282458000683 Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase, score -175.10, E-value 1.2e-06 282458000684 Pfam match to entry PF00465 Fe-ADH, Iron-containing alcohol dehydrogenase, score 491.50, E-value 6.4e-144 282458000685 PS00913 Iron-containing alcohol dehydrogenases signature 1. 282458000686 PS00060 Iron-containing alcohol dehydrogenases signature 2. 282458000687 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 282458000688 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 282458000689 2 probable transmembrane helices predicted for SAR0151 by TMHMM2.0 at aa 20-42 and 172-191 282458000690 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 282458000691 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 282458000692 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 282458000693 Pfam match to entry PF02811 PHP_C, PHP domain C-terminal region, score 46.40, E-value 6.4e-10 282458000694 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 282458000695 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 282458000696 NAD(P) binding site [chemical binding]; other site 282458000697 homodimer interface [polypeptide binding]; other site 282458000698 substrate binding site [chemical binding]; other site 282458000699 active site 282458000700 4 probable transmembrane helices predicted for SAR0154 by TMHMM2.0 at aa 10-32, 44-62, 77-99 and 104-126 282458000701 Pfam match to entry PF02719 Polysacc_synt_2, Polysaccharide biosynthesis protein, score 1243.80, E-value 0 282458000702 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 282458000703 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 282458000704 NAD(P) binding site [chemical binding]; other site 282458000705 homodimer interface [polypeptide binding]; other site 282458000706 substrate binding site [chemical binding]; other site 282458000707 active site 282458000708 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 282458000709 Pfam match to entry PF02719 Polysacc_synt_2, Polysaccharide biosynthesis protein, score -255.90, E-value 2.4e-09 282458000710 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 282458000711 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 282458000712 putative NAD(P) binding site [chemical binding]; other site 282458000713 active site 282458000714 putative substrate binding site [chemical binding]; other site 282458000715 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 282458000716 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 282458000717 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 282458000718 active site 282458000719 homodimer interface [polypeptide binding]; other site 282458000720 Pfam match to entry PF02350 Epimerase_2, UDP-N-acetylglucosamine 2-epimerase, score 604.50, E-value 6.2e-178 282458000721 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 282458000722 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 282458000723 12 probable transmembrane helices predicted for SAR0159 by TMHMM2.0 at aa 5-22, 27-44, 56-75, 90-112, 125-147, 174-196, 208-227, 231-248, 255-273, 376-398, 411-428 and 432-454 282458000724 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 282458000725 trimer interface [polypeptide binding]; other site 282458000726 active site 282458000727 substrate binding site [chemical binding]; other site 282458000728 CoA binding site [chemical binding]; other site 282458000729 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 8.30, E-value 68 282458000730 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 11.20, E-value 24 282458000731 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 11.80, E-value 16 282458000732 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 282458000733 Pfam match to entry PF01943 Polysacc_synt, Polysaccharide biosynthesis protein, score 17.40, E-value 0.00051 282458000734 12 probable transmembrane helices predicted for SAR0161 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 106-128, 141-163, 167-186, 217-236, 240-262, 283-305, 320-342, 354-371 and 381-403 282458000735 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 282458000736 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 282458000737 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 24.30, E-value 1.7e-05 282458000738 Bacterial sugar transferase; Region: Bac_transf; pfam02397 282458000739 Pfam match to entry PF02397 Bact_transf, Bacterial sugar transferase, score 143.70, E-value 3.3e-39 282458000740 1 probable transmembrane helix predicted for SAR0163 by TMHMM2.0 at aa 7-28 282458000741 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 282458000742 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 282458000743 putative NAD(P) binding site [chemical binding]; other site 282458000744 active site 282458000745 putative substrate binding site [chemical binding]; other site 282458000746 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 282458000747 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 282458000748 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 282458000749 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 282458000750 Pfam match to entry PF00984 UDPG_MGDP_dh, UDP-glucose/GDP-mannose dehydrogenase, score 656.30, E-value 1.5e-193 282458000751 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 282458000752 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 282458000753 active site 282458000754 homodimer interface [polypeptide binding]; other site 282458000755 Pfam match to entry PF02350 Epimerase_2, UDP-N-acetylglucosamine 2-epimerase, score 710.30, E-value 9.2e-210 282458000756 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 282458000757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 282458000758 Signal peptide predicted for SAR0168 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.348 between residues 32 and 33; signal peptide 282458000759 3 probable transmembrane helices predicted for SAR0168 by TMHMM2.0 at aa 4-38, 76-93 and 98-115 282458000760 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 282458000761 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 282458000762 NAD(P) binding site [chemical binding]; other site 282458000763 catalytic residues [active] 282458000764 Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase, score 703.70, E-value 8.4e-208 282458000765 PS00687 Aldehyde dehydrogenases glutamic acid active site. 282458000766 PS00070 Aldehyde dehydrogenases cysteine active site. 282458000767 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 282458000768 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 282458000769 6 probable transmembrane helices predicted for SAR0170 by TMHMM2.0 at aa 30-52, 62-81, 94-116, 131-153, 166-188 and 192-209 282458000770 Pfam match to entry PF01545 Cation_efflux, Cation efflux family, score 310.00, E-value 2.8e-89 282458000771 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 282458000772 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 282458000773 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 282458000774 Walker A/P-loop; other site 282458000775 ATP binding site [chemical binding]; other site 282458000776 Q-loop/lid; other site 282458000777 ABC transporter signature motif; other site 282458000778 Walker B; other site 282458000779 D-loop; other site 282458000780 H-loop/switch region; other site 282458000781 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 183.30, E-value 4e-51 282458000782 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000783 Signal peptide predicted for SAR0174 by SignalP 2.0 HMM (Signal peptide probabilty 0.652) with cleavage site probability 0.583 between residues 25 and 26; signal peptide 282458000784 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 282458000785 NMT1-like family; Region: NMT1_2; pfam13379 282458000786 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458000787 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 282458000788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 282458000789 6 probable transmembrane helices predicted for SAR0175 by TMHMM2.0 at aa 9-31, 35-57, 64-86, 116-138, 180-202 and 222-241 282458000790 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 282458000791 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 282458000792 Uncharacterized conserved protein [Function unknown]; Region: COG5609 282458000793 formate dehydrogenase; Provisional; Region: PRK07574 282458000794 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 282458000795 dimerization interface [polypeptide binding]; other site 282458000796 ligand binding site [chemical binding]; other site 282458000797 NAD binding site [chemical binding]; other site 282458000798 catalytic site [active] 282458000799 Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 76.00, E-value 7.6e-19 282458000800 Pfam match to entry PF02826 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 250.10, E-value 3.1e-71 282458000801 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 282458000802 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 282458000803 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 282458000804 12 probable transmembrane helices predicted for SAR0179 by TMHMM2.0 at aa 13-32, 42-64, 71-90, 95-114, 135-157, 162-184, 225-247, 270-292, 299-316, 320-342, 355-377 and 387-409 282458000805 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 282458000806 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 282458000807 acyl-activating enzyme (AAE) consensus motif; other site 282458000808 AMP binding site [chemical binding]; other site 282458000809 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 282458000810 Condensation domain; Region: Condensation; pfam00668 282458000811 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 282458000812 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 282458000813 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 282458000814 acyl-activating enzyme (AAE) consensus motif; other site 282458000815 AMP binding site [chemical binding]; other site 282458000816 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 282458000817 thioester reductase domain; Region: Thioester-redct; TIGR01746 282458000818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 282458000819 NAD(P) binding site [chemical binding]; other site 282458000820 active site 282458000821 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 448.90, E-value 4.5e-131 282458000822 PS00455 AMP-binding domain signature. 282458000823 Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site, score 70.70, E-value 6e-18 282458000824 PS00012 Phosphopantetheine attachment site. 282458000825 Pfam match to entry PF00668 Condensation, Condensation domain, score 221.30, E-value 1.2e-62 282458000826 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 386.50, E-value 2.7e-112 282458000827 Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site, score 50.50, E-value 2.4e-12 282458000828 PS00012 Phosphopantetheine attachment site. 282458000829 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 282458000830 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 282458000831 Pfam match to entry PF01648 ACPS, 4'-phosphopantetheinyl transferase superfamily, score 4.00, E-value 0.03 282458000832 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 282458000833 4 probable transmembrane helices predicted for SAR0182 by TMHMM2.0 at aa 7-29, 69-91, 103-125 and 140-158 282458000834 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 282458000835 nucleotide binding site [chemical binding]; other site 282458000836 N-acetyl-L-glutamate binding site [chemical binding]; other site 282458000837 Pfam match to entry PF00696 aakinase, Amino acid kinase, score 103.30, E-value 4.7e-27 282458000838 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 282458000839 heterotetramer interface [polypeptide binding]; other site 282458000840 active site pocket [active] 282458000841 cleavage site 282458000842 Pfam match to entry PF01960 ArgJ, ArgJ family, score 652.00, E-value 3.1e-192 282458000843 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 282458000844 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 282458000845 Pfam match to entry PF02774 Semialdhyde_dhC, Semialdehyde dehydrogenase, dimerisation domain, score 160.80, E-value 2.3e-44 282458000846 PS01224 N-acetyl-gamma-glutamyl-phosphate reductase active site. 282458000847 Pfam match to entry PF01118 Semialdhyde_dh, Semialdehyde dehydrogenase, NAD binding domain, score 91.60, E-value 1.6e-28 282458000848 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 282458000849 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 282458000850 inhibitor-cofactor binding pocket; inhibition site 282458000851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458000852 catalytic residue [active] 282458000853 Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III, score 569.90, E-value 8.5e-171 282458000854 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 282458000855 Signal peptide predicted for SAR0187 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.721 between residues 36 and 37; signal peptide 282458000856 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 282458000857 12 probable transmembrane helices predicted for SAR0187 by TMHMM2.0 at aa 12-31, 41-63, 84-106, 121-140, 153-175, 195-217, 238-260, 275-297, 318-340, 344-366, 373-390 and 422-441 282458000858 Isochorismatase family; Region: Isochorismatase; pfam00857 282458000859 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 282458000860 catalytic triad [active] 282458000861 conserved cis-peptide bond; other site 282458000862 Pfam match to entry PF00857 Isochorismatase, Isochorismatase, score 157.40, E-value 2.5e-43 282458000863 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 282458000864 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 282458000865 dimer interface [polypeptide binding]; other site 282458000866 PYR/PP interface [polypeptide binding]; other site 282458000867 TPP binding site [chemical binding]; other site 282458000868 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 282458000869 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 282458000870 TPP-binding site [chemical binding]; other site 282458000871 dimer interface [polypeptide binding]; other site 282458000872 Pfam match to entry PF02775 TPP_enzymes_C, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 154.30, E-value 2.1e-42 282458000873 Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzyme, central domain, score 17.40, E-value 2e-05 282458000874 Pfam match to entry PF02776 TPP_enzymes_N, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 183.70, E-value 2.9e-51 282458000875 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282458000876 Signal peptide predicted for SAR0190 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.367 between residues 37 and 38; signal peptide 282458000877 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 282458000878 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282458000879 active site turn [active] 282458000880 phosphorylation site [posttranslational modification] 282458000881 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 282458000882 HPr interaction site; other site 282458000883 glycerol kinase (GK) interaction site [polypeptide binding]; other site 282458000884 active site 282458000885 phosphorylation site [posttranslational modification] 282458000886 Pfam match to entry PF00358 PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1, score 239.50, E-value 4.8e-68 282458000887 PS00371 PTS EIIA domains phosphorylation site signature 1. 282458000888 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 65.80, E-value 1.8e-17 282458000889 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282458000890 10 probable transmembrane helices predicted for SAR0190 by TMHMM2.0 at aa 12-34, 74-96, 126-148, 170-192, 197-219, 278-296, 303-321, 326-348, 355-374 and 380-402 282458000891 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 519.40, E-value 2.6e-152 282458000892 Uncharacterized conserved protein [Function unknown]; Region: COG3589 282458000893 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 282458000894 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 282458000895 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 282458000896 putative active site [active] 282458000897 Pfam match to entry PF01380 SIS, SIS domain, score 5.80, E-value 0.03 282458000898 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000899 PS01272 Glucokinase regulatory protein family signature. 282458000900 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 282458000901 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282458000902 active site turn [active] 282458000903 phosphorylation site [posttranslational modification] 282458000904 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282458000905 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 57.60, E-value 4.4e-15 282458000906 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282458000907 10 probable transmembrane helices predicted for SAR0193 by TMHMM2.0 at aa 132-154, 169-191, 204-226, 236-255, 268-290, 305-327, 347-369, 384-401, 408-430 and 450-472 282458000908 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 139.90, E-value 4.7e-38 282458000909 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 282458000910 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 282458000911 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 282458000912 putative active site [active] 282458000913 Pfam match to entry PF01418 HTH_6, Helix-turn-helix domain, rpiR family, score 100.80, E-value 2.7e-26 282458000914 Pfam match to entry PF01380 SIS, SIS domain, score 47.00, E-value 4.2e-10 282458000915 3 probable transmembrane helices predicted for SAR0195 by TMHMM2.0 at aa 2-20, 30-52 and 65-87 282458000916 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 282458000917 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 282458000918 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282458000919 ATP binding site [chemical binding]; other site 282458000920 putative Mg++ binding site [ion binding]; other site 282458000921 PS00012 Phosphopantetheine attachment site. 282458000922 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 282458000923 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282458000924 Walker A/P-loop; other site 282458000925 ATP binding site [chemical binding]; other site 282458000926 Q-loop/lid; other site 282458000927 ABC transporter signature motif; other site 282458000928 Walker B; other site 282458000929 D-loop; other site 282458000930 H-loop/switch region; other site 282458000931 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 282458000932 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282458000933 Walker A/P-loop; other site 282458000934 ATP binding site [chemical binding]; other site 282458000935 Q-loop/lid; other site 282458000936 ABC transporter signature motif; other site 282458000937 Walker B; other site 282458000938 D-loop; other site 282458000939 H-loop/switch region; other site 282458000940 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 217.80, E-value 1.7e-61 282458000941 PS00211 ABC transporters family signature. 282458000942 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000943 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 209.30, E-value 5.8e-59 282458000944 PS00211 ABC transporters family signature. 282458000945 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000946 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 282458000947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458000948 dimer interface [polypeptide binding]; other site 282458000949 conserved gate region; other site 282458000950 putative PBP binding loops; other site 282458000951 ABC-ATPase subunit interface; other site 282458000952 8 probable transmembrane helices predicted for SAR0199 by TMHMM2.0 at aa 7-29, 103-125, 132-154, 221-243, 256-278, 293-315, 351-373 and 401-423 282458000953 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 25.40, E-value 0.0013 282458000954 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 282458000955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458000956 dimer interface [polypeptide binding]; other site 282458000957 conserved gate region; other site 282458000958 ABC-ATPase subunit interface; other site 282458000959 9 probable transmembrane helices predicted for SAR0200 by TMHMM2.0 at aa 15-34, 41-60, 75-97, 125-147, 193-215, 228-247, 251-273, 311-333 and 353-375 282458000960 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 40.40, E-value 4.1e-08 282458000961 Signal peptide predicted for SAR0201 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.666 between residues 27 and 28; signal peptide 282458000962 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 282458000963 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 282458000964 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 282458000965 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458000966 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 282458000967 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 282458000968 Pfam match to entry PF01019 G_glu_transpept, Gamma-glutamyltranspeptidase, score 550.40, E-value 1.3e-161 282458000969 azoreductase; Reviewed; Region: PRK00170 282458000970 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 282458000971 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000972 Signal peptide predicted for SAR0204 by SignalP 2.0 HMM (Signal peptide probabilty 0.938) with cleavage site probability 0.645 between residues 24 and 25; signal peptide 282458000973 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 282458000974 Peptidase family M23; Region: Peptidase_M23; pfam01551 282458000975 1 probable transmembrane helix predicted for SAR0204 by TMHMM2.0 at aa 7-25 282458000976 Pfam match to entry PF01551 Peptidase_M37, Peptidase M23/M37, score 96.10, E-value 7e-25 282458000977 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 282458000978 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 282458000979 Walker A/P-loop; other site 282458000980 ATP binding site [chemical binding]; other site 282458000981 Q-loop/lid; other site 282458000982 ABC transporter signature motif; other site 282458000983 Walker B; other site 282458000984 D-loop; other site 282458000985 H-loop/switch region; other site 282458000986 TOBE domain; Region: TOBE; pfam03459 282458000987 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 220.80, E-value 2e-62 282458000988 PS00017 ATP/GTP-binding site motif A (P-loop). 282458000989 PS00211 ABC transporters family signature. 282458000990 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 282458000991 Signal peptide predicted for SAR0206 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.962 between residues 28 and 29; signal peptide 282458000992 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 282458000993 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458000994 Pfam match to entry PF01547 SBP_bacterial_1, Bacterial extracellular solute-binding protein, score 182.70, E-value 5.8e-51 282458000995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458000996 dimer interface [polypeptide binding]; other site 282458000997 conserved gate region; other site 282458000998 ABC-ATPase subunit interface; other site 282458000999 8 probable transmembrane helices predicted for SAR0207 by TMHMM2.0 at aa 31-53, 68-90, 122-144, 192-214, 227-249, 279-301, 326-345 and 388-410 282458001000 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 53.00, E-value 6.6e-12 282458001001 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282458001002 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 282458001003 Signal peptide predicted for SAR0208 by SignalP 2.0 HMM (Signal peptide probabilty 0.806) with cleavage site probability 0.559 between residues 44 and 45; signal peptide 282458001004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458001005 dimer interface [polypeptide binding]; other site 282458001006 conserved gate region; other site 282458001007 putative PBP binding loops; other site 282458001008 ABC-ATPase subunit interface; other site 282458001009 6 probable transmembrane helices predicted for SAR0208 by TMHMM2.0 at aa 12-34, 75-97, 109-131, 141-163, 184-206 and 242-264 282458001010 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 72.90, E-value 6.5e-18 282458001011 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282458001012 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 282458001013 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 282458001014 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 282458001015 Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase, NAD-binding Rossmann fold, score 147.60, E-value 2.2e-40 282458001016 Pfam match to entry PF02894 GFO_IDH_MocA_C, Oxidoreductase, C-terminal alpha/beta domain, score 10.60, E-value 0.12 282458001017 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 282458001018 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 282458001019 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 282458001020 Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase, NAD-binding Rossmann fold, score 142.50, E-value 7.3e-39 282458001021 Pfam match to entry PF02894 GFO_IDH_MocA_C, Oxidoreductase, C-terminal alpha/beta domain, score 28.90, E-value 0.00011 282458001022 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 282458001023 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 282458001024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 282458001025 3 probable transmembrane helices predicted for SAR0212 by TMHMM2.0 at aa 43-60, 65-87 and 131-153 282458001026 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 282458001027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458001028 putative substrate translocation pore; other site 282458001029 12 probable transmembrane helices predicted for SAR0213 by TMHMM2.0 at aa 22-44, 64-86, 99-121, 125-147, 160-180, 190-212, 252-274, 294-316, 325-344, 354-376, 389-408 and 428-450 282458001030 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -133.20, E-value 0.047 282458001031 PS00942 glpT family of transporters signature. 282458001032 Response regulator receiver domain; Region: Response_reg; pfam00072 282458001033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458001034 active site 282458001035 phosphorylation site [posttranslational modification] 282458001036 intermolecular recognition site; other site 282458001037 dimerization interface [polypeptide binding]; other site 282458001038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 282458001039 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 282458001040 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 282458001041 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 64.40, E-value 2.4e-15 282458001042 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 79.40, E-value 7.6e-20 282458001043 Signal peptide predicted for SAR0215 by SignalP 2.0 HMM (Signal peptide probabilty 0.978) with cleavage site probability 0.496 between residues 35 and 36; signal peptide 282458001044 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 282458001045 Histidine kinase; Region: His_kinase; pfam06580 282458001046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458001047 ATP binding site [chemical binding]; other site 282458001048 Mg2+ binding site [ion binding]; other site 282458001049 G-X-G motif; other site 282458001050 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 20.80, E-value 0.00023 282458001051 2 probable transmembrane helices predicted for SAR0215 by TMHMM2.0 at aa 15-37 and 222-244 282458001052 Signal peptide predicted for SAR0216 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.756 between residues 24 and 25; signal peptide 282458001053 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 282458001054 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 282458001055 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458001056 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 282458001057 Pyruvate formate lyase 1; Region: PFL1; cd01678 282458001058 coenzyme A binding site [chemical binding]; other site 282458001059 active site 282458001060 catalytic residues [active] 282458001061 glycine loop; other site 282458001062 Pfam match to entry PF02901 PFL, Pyruvate formate lyase, score 1147.30, E-value 0 282458001063 Pfam match to entry PF01228 Gly_radical, Glycine radical, score 169.50, E-value 5.7e-47 282458001064 PS00850 Glycine radical signature. 282458001065 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 282458001066 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282458001067 FeS/SAM binding site; other site 282458001068 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 282458001069 Pfam match to entry PF02143 Radical_activat, Radical activating enzyme, score 50.40, E-value 4e-11 282458001070 PS01087 Radical activating enzymes signature. 282458001071 PS00190 Cytochrome c family heme-binding site signature. 282458001072 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 282458001073 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 282458001074 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 282458001075 putative active site [active] 282458001076 catalytic site [active] 282458001077 putative metal binding site [ion binding]; other site 282458001078 7 probable transmembrane helices predicted for SAR0220 by TMHMM2.0 at aa 21-43, 70-101, 122-144, 174-196, 223-245, 255-274 and 312-334 282458001079 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 282458001080 Signal peptide predicted for SAR0222 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.978 between residues 26 and 27; signal peptide 282458001081 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 282458001082 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 282458001083 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 282458001084 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 282458001085 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 282458001086 PS00429 Staphylocoagulase repeat signature. 282458001087 PS00429 Staphylocoagulase repeat signature. 282458001088 PS00429 Staphylocoagulase repeat signature. 282458001089 PS00429 Staphylocoagulase repeat signature. 282458001090 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 282458001091 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 282458001092 dimer interface [polypeptide binding]; other site 282458001093 active site 282458001094 1 probable transmembrane helix predicted for SAR0223 by TMHMM2.0 at aa 371-393 282458001095 Pfam match to entry PF02803 thiolase_C, Thiolase, C-terminal domain, score 223.30, E-value 3.6e-63 282458001096 PS00099 Thiolases active site. 282458001097 PS00737 Thiolases signature 2. 282458001098 Pfam match to entry PF00108 thiolase, Thiolase, N-terminal domain, score 314.50, E-value 1.2e-90 282458001099 PS00098 Thiolases acyl-enzyme intermediate signature. 282458001100 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 282458001101 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 282458001102 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 282458001103 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 282458001104 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 282458001105 substrate binding site [chemical binding]; other site 282458001106 oxyanion hole (OAH) forming residues; other site 282458001107 trimer interface [polypeptide binding]; other site 282458001108 Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase, score 23.10, E-value 6.8e-09 282458001109 PS00166 Enoyl-CoA hydratase/isomerase signature. 282458001110 Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain, score 35.10, E-value 1.4e-06 282458001111 Pfam match to entry PF02737 3HCDH_N, 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain, score 110.80, E-value 2.7e-29 282458001112 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 282458001113 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 282458001114 active site 282458001115 Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase, C-terminal domain, score 57.80, E-value 8.6e-15 282458001116 Pfam match to entry PF02770 Acyl-CoA_dh_M, Acyl-CoA dehydrogenase, middle domain, score 50.80, E-value 4.2e-13 282458001117 Pfam match to entry PF02771 Acyl-CoA_dh_N, Acyl-CoA dehydrogenase, N-terminal domain, score 19.30, E-value 0.00055 282458001118 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 282458001119 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 282458001120 acyl-activating enzyme (AAE) consensus motif; other site 282458001121 AMP binding site [chemical binding]; other site 282458001122 active site 282458001123 CoA binding site [chemical binding]; other site 282458001124 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 391.30, E-value 9.6e-114 282458001125 PS00455 AMP-binding domain signature. 282458001126 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 282458001127 Coenzyme A transferase; Region: CoA_trans; smart00882 282458001128 Coenzyme A transferase; Region: CoA_trans; cl17247 282458001129 Pfam match to entry PF01144 CoA_trans, Coenzyme A transferase, score 58.20, E-value 1.7e-13 282458001130 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 282458001131 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 282458001132 catalytic triad [active] 282458001133 Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I, score -18.40, E-value 0.00024 282458001134 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 282458001135 8 probable transmembrane helices predicted for SAR0229 by TMHMM2.0 at aa 107-129, 134-156, 169-191, 206-228, 235-257, 272-294, 315-337 and 342-361 282458001136 Signal peptide predicted for SAR0230 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.826 between residues 26 and 27; signal peptide 282458001137 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 282458001138 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 282458001139 Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 66.10, E-value 1.2e-17 282458001140 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458001141 Uncharacterized conserved protein [Function unknown]; Region: COG3189 282458001142 2 probable transmembrane helices predicted for SAR0232 by TMHMM2.0 at aa 7-24 and 34-51 282458001143 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 282458001144 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 282458001145 heme-binding site [chemical binding]; other site 282458001146 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 282458001147 FAD binding pocket [chemical binding]; other site 282458001148 FAD binding motif [chemical binding]; other site 282458001149 phosphate binding motif [ion binding]; other site 282458001150 beta-alpha-beta structure motif; other site 282458001151 NAD binding pocket [chemical binding]; other site 282458001152 Heme binding pocket [chemical binding]; other site 282458001153 Pfam match to entry PF00175 NAD_binding, Oxidoreductase FAD/NAD-binding domain, score 1.70, E-value 0.0012 282458001154 Pfam match to entry PF00970 FAD_binding_6, Oxidoreductase FAD-binding domain, score 37.90, E-value 2.3e-07 282458001155 Pfam match to entry PF00042 globin, Globin, score 54.20, E-value 2.8e-14 282458001156 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 282458001157 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 282458001158 tetramer (dimer of dimers) interface [polypeptide binding]; other site 282458001159 NAD binding site [chemical binding]; other site 282458001160 dimer interface [polypeptide binding]; other site 282458001161 substrate binding site [chemical binding]; other site 282458001162 Pfam match to entry PF00056 ldh, lactate/malate dehydrogenase, NAD binding domain, score 249.80, E-value 3.7e-71 282458001163 Pfam match to entry PF02866 ldh_C, lactate/malate dehydrogenase, alpha/beta C-terminal domain, score 285.90, E-value 4.9e-82 282458001164 PS00064 L-lactate dehydrogenase active site. 282458001165 Signal peptide predicted for SAR0235 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.705 between residues 43 and 44; signal peptide 282458001166 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 282458001167 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282458001168 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282458001169 active site turn [active] 282458001170 phosphorylation site [posttranslational modification] 282458001171 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 52.40, E-value 1.4e-13 282458001172 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282458001173 11 probable transmembrane helices predicted for SAR0235 by TMHMM2.0 at aa 15-37, 58-80, 93-115, 128-150, 170-192, 199-221, 280-302, 309-327, 332-354, 361-383 and 388-410 282458001174 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 502.80, E-value 2.5e-147 282458001175 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 282458001176 active site 282458001177 tetramer interface [polypeptide binding]; other site 282458001178 Pfam match to entry PF01156 IU_nuc_hydro, Inosine-uridine preferring nucleoside hydrolase, score 381.20, E-value 1e-110 282458001179 PS01247 Inosine-uridine preferring nucleoside hydrolase signature. 282458001180 PS00018 EF-hand calcium-binding domain. 282458001181 Similar to Bacillus halodurans hypothetical protein BH0193 TR:Q9KGB4 (EMBL:AP001507) (683 aa) fasta scores: E(): 9.6e-81, 37.010% id in 689 aa, and to Streptococcus pyogenes hypothetical protein SPY1952 TR:Q99XZ1 (EMBL:AE006618) (686 aa) fasta scores: E(): 2.5e-33, 24.286% id in 700 aa. Contains a nonsense mutation (opal) after codon 473; PTS multi-domain regulator (pseudogene) 282458001182 Predicted helix-turn-helix motif with score 1056 (+2.78 SD) at aa 18-39, sequence IHGKELESIFGLSRRQLGYRIQ 282458001183 Pfam match to entry PF00874 BglG_antitermin, Transcriptional antiterminator bglG family, score 22.70, E-value 3.7e-05 282458001184 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score -3.80, E-value 2.3e-05 282458001185 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282458001186 active site 282458001187 phosphorylation site [posttranslational modification] 282458001188 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 44.00, E-value 2.4e-09 282458001189 Signal peptide predicted for SAR0241 by SignalP 2.0 HMM (Signal peptide probabilty 0.859) with cleavage site probability 0.422 between residues 26 and 27; signal peptide 282458001190 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 282458001191 active site 282458001192 P-loop; other site 282458001193 phosphorylation site [posttranslational modification] 282458001194 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 282458001195 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 282458001196 9 probable transmembrane helices predicted for SAR0242 by TMHMM2.0 at aa 10-31, 38-60, 92-114, 135-157, 177-199, 220-242, 303-325, 330-352 and 357-379 282458001197 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 282458001198 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 282458001199 putative NAD(P) binding site [chemical binding]; other site 282458001200 catalytic Zn binding site [ion binding]; other site 282458001201 structural Zn binding site [ion binding]; other site 282458001202 Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases, score 323.40, E-value 2.7e-93 282458001203 PS00059 Zinc-containing alcohol dehydrogenases signature. 282458001204 1 probable transmembrane helix predicted for SAR0244 by TMHMM2.0 at aa 19-41 282458001205 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 282458001206 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 282458001207 putative NAD(P) binding site [chemical binding]; other site 282458001208 catalytic Zn binding site [ion binding]; other site 282458001209 Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases, score 296.00, E-value 4.5e-85 282458001210 PS00059 Zinc-containing alcohol dehydrogenases signature. 282458001211 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 282458001212 substrate binding site; other site 282458001213 dimer interface; other site 282458001214 Pfam match to entry PF01128 UPF0007, Uncharacterized protein family UPF0007, score 93.70, E-value 3.6e-24 282458001215 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 282458001216 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 282458001217 putative NAD(P) binding site [chemical binding]; other site 282458001218 putative catalytic Zn binding site [ion binding]; other site 282458001219 Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases, score 39.90, E-value 1.4e-09 282458001220 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 282458001221 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 282458001222 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 282458001223 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 282458001224 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 282458001225 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 282458001226 substrate binding site; other site 282458001227 dimer interface; other site 282458001228 Pfam match to entry PF01128 UPF0007, Uncharacterized protein family UPF0007, score 89.60, E-value 6.1e-23 282458001229 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 282458001230 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 282458001231 putative NAD(P) binding site [chemical binding]; other site 282458001232 putative catalytic Zn binding site [ion binding]; other site 282458001233 Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases, score 27.00, E-value 8.9e-09 282458001234 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 282458001235 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 282458001236 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 282458001237 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 282458001238 active site 282458001239 Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferase, score 136.20, E-value 5.8e-37 282458001240 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 282458001241 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 282458001242 Hemerythrin-like domain; Region: Hr-like; cd12108 282458001243 Fe binding site [ion binding]; other site 282458001244 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 282458001245 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 282458001246 Histidine kinase; Region: His_kinase; pfam06580 282458001247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458001248 Mg2+ binding site [ion binding]; other site 282458001249 G-X-G motif; other site 282458001250 6 probable transmembrane helices predicted for SAR0257 by TMHMM2.0 at aa 6-28, 40-62, 88-110, 123-140, 155-172 and 184-206 282458001251 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 48.70, E-value 4.4e-12 282458001252 two-component response regulator; Provisional; Region: PRK14084 282458001253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458001254 active site 282458001255 phosphorylation site [posttranslational modification] 282458001256 intermolecular recognition site; other site 282458001257 dimerization interface [polypeptide binding]; other site 282458001258 LytTr DNA-binding domain; Region: LytTR; pfam04397 282458001259 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 112.60, E-value 7.6e-30 282458001260 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 282458001261 4 probable transmembrane helices predicted for SAR0259 by TMHMM2.0 at aa 13-32, 42-64, 71-93 and 97-119 282458001262 antiholin-like protein LrgB; Provisional; Region: PRK04288 282458001263 7 probable transmembrane helices predicted for SAR0260 by TMHMM2.0 at aa 5-27, 34-56, 67-84, 97-116, 126-148, 155-177 and 210-232 282458001264 Signal peptide predicted for SAR0261 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.482 between residues 29 and 30; signal peptide 282458001265 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 282458001266 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 282458001267 14 probable transmembrane helices predicted for SAR0261 by TMHMM2.0 at aa 13-32, 234-256, 294-316, 336-358, 371-393, 413-435, 456-478, 493-515, 528-550, 555-577, 598-620, 640-659, 680-702 and 737-754 282458001268 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 282458001269 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 282458001270 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 282458001271 DNA-binding site [nucleotide binding]; DNA binding site 282458001272 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 282458001273 Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 54.60, E-value 2.6e-15 282458001274 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 282458001275 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 282458001276 HPr interaction site; other site 282458001277 glycerol kinase (GK) interaction site [polypeptide binding]; other site 282458001278 active site 282458001279 phosphorylation site [posttranslational modification] 282458001280 Pfam match to entry PF00358 PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1, score 129.70, E-value 1.1e-35 282458001281 PS00371 PTS EIIA domains phosphorylation site signature 1. 282458001282 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 282458001283 beta-galactosidase; Region: BGL; TIGR03356 282458001284 Pfam match to entry PF00232 Glyco_hydro_1, Glycosyl hydrolase 1, score 234.50, E-value 1.5e-66 282458001285 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 282458001286 Pfam match to entry PF00232 Glyco_hydro_1, Glycosyl hydrolase 1, score 269.70, E-value 3.8e-77 282458001287 PS00572 Glycosyl hydrolases family 1 active site. 282458001288 Methyltransferase domain; Region: Methyltransf_31; pfam13847 282458001289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458001290 S-adenosylmethionine binding site [chemical binding]; other site 282458001291 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 282458001292 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 282458001293 substrate binding site [chemical binding]; other site 282458001294 dimer interface [polypeptide binding]; other site 282458001295 ATP binding site [chemical binding]; other site 282458001296 Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 263.60, E-value 2.6e-75 282458001297 PS00584 pfkB family of carbohydrate kinases signature 2. 282458001298 D-ribose pyranase; Provisional; Region: PRK11797 282458001299 Signal peptide predicted for SAR0268 by SignalP 2.0 HMM (Signal peptide probabilty 0.929) with cleavage site probability 0.463 between residues 25 and 26; signal peptide 282458001300 Sugar transport protein; Region: Sugar_transport; pfam06800 282458001301 10 probable transmembrane helices predicted for SAR0268 by TMHMM2.0 at aa 2-24, 34-56, 63-80, 95-117, 122-139, 154-171, 180-202, 212-234, 241-263 and 273-292 282458001302 Transcriptional regulators [Transcription]; Region: PurR; COG1609 282458001303 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 282458001304 DNA binding site [nucleotide binding] 282458001305 domain linker motif; other site 282458001306 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 282458001307 dimerization interface [polypeptide binding]; other site 282458001308 ligand binding site [chemical binding]; other site 282458001309 Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family., score 43.80, E-value 4e-09 282458001310 Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, score 49.50, E-value 1.3e-12 282458001311 Predicted helix-turn-helix motif with score 2168 (+6.57 SD) at aa 4-25, sequence VSIKDVAREAGVSVTTVSHILN 282458001312 PS00356 Bacterial regulatory proteins, lacI family signature. 282458001313 Signal peptide predicted for SAR0271 by SignalP 2.0 HMM (Signal peptide probabilty 0.938) with cleavage site probability 0.705 between residues 58 and 59; signal peptide 282458001314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458001315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458001316 14 probable transmembrane helices predicted for SAR0271 by TMHMM2.0 at aa 12-34, 44-66, 79-98, 102-124, 137-159, 163-182, 202-221, 225-247, 268-290, 296-318, 330-352, 357-379, 391-413 and 428-450 282458001317 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 282458001318 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 282458001319 active site 282458001320 Pfam match to entry PF02275 CBAH, Choloylglycine hydrolase, score 231.10, E-value 1.6e-65 282458001321 Signal peptide predicted for SAR0273 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.766 between residues 25 and 26; signal peptide 282458001322 Surface antigen [General function prediction only]; Region: COG3942 282458001323 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 282458001324 Peptidase family M23; Region: Peptidase_M23; pfam01551 282458001325 Pfam match to entry PF01551 Peptidase_M37, Peptidase M23/M37, score 141.60, E-value 1.4e-38 282458001326 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 282458001327 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 282458001328 Walker A/P-loop; other site 282458001329 ATP binding site [chemical binding]; other site 282458001330 Q-loop/lid; other site 282458001331 ABC transporter signature motif; other site 282458001332 Walker B; other site 282458001333 D-loop; other site 282458001334 H-loop/switch region; other site 282458001335 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 157.80, E-value 1.9e-43 282458001336 PS00211 ABC transporters family signature. 282458001337 PS00017 ATP/GTP-binding site motif A (P-loop). 282458001338 5 probable transmembrane helices predicted for SAR0275 by TMHMM2.0 at aa 15-37, 185-207, 227-249, 256-278 and 283-305 282458001339 Signal peptide predicted for SAR0276 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.981 between residues 43 and 44; signal peptide 282458001340 6 probable transmembrane helices predicted for SAR0276 by TMHMM2.0 at aa 20-42, 199-221, 242-264, 279-301, 313-335 and 367-384 282458001341 Signal peptide predicted for SAR0277 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.803 between residues 30 and 31; signal peptide 282458001342 1 probable transmembrane helix predicted for SAR0277 by TMHMM2.0 at aa 7-29 282458001343 Signal peptide predicted for SAR0278 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.787 between residues 27 and 28; signal peptide 282458001344 Surface antigen [General function prediction only]; Region: COG3942 282458001345 CHAP domain; Region: CHAP; pfam05257 282458001346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 282458001347 Signal peptide predicted for SAR0280 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.573 between residues 27 and 28; signal peptide 282458001348 Predicted membrane protein [Function unknown]; Region: COG1511 282458001349 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 282458001350 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 282458001351 6 probable transmembrane helices predicted for SAR0280 by TMHMM2.0 at aa 5-27, 821-843, 864-886, 901-923, 928-945 and 978-1000 282458001352 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 282458001353 1 probable transmembrane helix predicted for SAR0281 by TMHMM2.0 at aa 115-137 282458001354 Uncharacterized small protein [Function unknown]; Region: COG5417 282458001355 Predicted membrane protein [Function unknown]; Region: COG4499 282458001356 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 282458001357 1 probable transmembrane helix predicted for SAR0283 by TMHMM2.0 at aa 229-251 282458001358 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 282458001359 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 282458001360 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 282458001361 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 282458001362 2 probable transmembrane helices predicted for SAR0284 by TMHMM2.0 at aa 230-252 and 257-279 282458001363 Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family, score 140.70, E-value 2.5e-38 282458001364 PS00017 ATP/GTP-binding site motif A (P-loop). 282458001365 Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family, score 125.60, E-value 9e-34 282458001366 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 282458001367 LXG domain of WXG superfamily; Region: LXG; pfam04740 282458001368 6 probable transmembrane helices predicted for SAR0288 by TMHMM2.0 at aa 13-35, 45-63, 83-105, 110-132, 145-167 and 177-196 282458001369 Signal peptide predicted for SAR0291 by SignalP 2.0 HMM (Signal peptide probabilty 0.789) with cleavage site probability 0.299 between residues 23 and 24; signal peptide 282458001370 6 probable transmembrane helices predicted for SAR0291 by TMHMM2.0 at aa 4-22, 27-49, 59-81, 116-133, 143-165 and 172-194 282458001371 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 282458001372 2 probable transmembrane helices predicted for SAR0292 by TMHMM2.0 at aa 12-34 and 49-71 282458001373 Protein of unknown function, DUF600; Region: DUF600; cl04640 282458001374 Protein of unknown function, DUF600; Region: DUF600; cl04640 282458001375 Similar to Bacillus halodurans hypothetical protein BH3703 TR:Q9K6M5 (EMBL:AP001519) (169 aa) fasta scores: E(): 2.8e-09, 30.818% id in 159 aa, and to C-terminal region of Bacillus subtilis hypothetical protein YeeF TR:O31506 (EMBL:Z99107) (827 aa) fasta scores: E(): 7e-10, 30.556% id in 144 aa. Contains a nonsense mutation (opal) after codon 118;conserved hypothetical protein (pseudogene) 282458001376 Similar to Bacillus halodurans hypothetical protein BH3703 TR:Q9K6M5 (EMBL:AP001519) (169 aa) fasta scores: E(): 5.4e-07, 30.189% id in 159 aa, and to Bacillus subtilis hypothetical protein YeeF TR:O31506 (EMBL:Z99107) (827 aa) fasta scores: E(): 6.1e-09, 28.082% id in 146 aa. Contains a nonsense mutation (ochre) after codon 90;conserved hypothetical protein (pseudogene) 282458001377 Signal peptide predicted for SAR0301 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.573 between residues 30 and 31; signal peptide 282458001378 3 probable transmembrane helices predicted for SAR0301 by TMHMM2.0 at aa 7-29, 57-79 and 91-113 282458001379 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 282458001380 Pfam match to entry PF01226 Form_Nir_trans, Formate/nitrite transporter, score 57.50, E-value 3e-13 282458001381 6 probable transmembrane helices predicted for SAR0302 by TMHMM2.0 at aa 38-60, 75-97, 117-139, 165-187, 194-216 and 242-264 282458001382 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 282458001383 Signal peptide predicted for SAR0303 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.391 between residues 31 and 32; signal peptide 282458001384 12 probable transmembrane helices predicted for SAR0303 by TMHMM2.0 at aa 5-27, 37-59, 72-94, 109-131, 143-165, 189-211, 223-245, 275-297, 310-332, 336-358, 371-393 and 408-427 282458001385 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 282458001386 Signal peptide predicted for SAR0304 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.970 between residues 31 and 32; signal peptide 282458001387 Signal peptide predicted for SAR0305 by SignalP 2.0 HMM (Signal peptide probabilty 0.863) with cleavage site probability 0.554 between residues 36 and 37; signal peptide 282458001388 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 282458001389 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 282458001390 FtsX-like permease family; Region: FtsX; pfam02687 282458001391 4 probable transmembrane helices predicted for SAR0305 by TMHMM2.0 at aa 13-35, 230-252, 273-295 and 315-337 282458001392 Pfam match to entry PF02687 DUF214, Predicted permease, score 30.50, E-value 5.7e-06 282458001393 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 282458001394 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282458001395 Walker A/P-loop; other site 282458001396 ATP binding site [chemical binding]; other site 282458001397 Q-loop/lid; other site 282458001398 ABC transporter signature motif; other site 282458001399 Walker B; other site 282458001400 D-loop; other site 282458001401 H-loop/switch region; other site 282458001402 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 180.10, E-value 3.5e-50 282458001403 PS00017 ATP/GTP-binding site motif A (P-loop). 282458001404 PS00211 ABC transporters family signature. 282458001405 Signal peptide predicted for SAR0307 by SignalP 2.0 HMM (Signal peptide probabilty 0.912) with cleavage site probability 0.427 between residues 37 and 38; signal peptide 282458001406 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 282458001407 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 282458001408 9 probable transmembrane helices predicted for SAR0307 by TMHMM2.0 at aa 4-23, 30-47, 67-86, 93-115, 130-152, 172-191, 196-218, 254-276 and 302-324 282458001409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282458001410 non-specific DNA binding site [nucleotide binding]; other site 282458001411 salt bridge; other site 282458001412 sequence-specific DNA binding site [nucleotide binding]; other site 282458001413 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 282458001414 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 282458001415 substrate binding site [chemical binding]; other site 282458001416 ATP binding site [chemical binding]; other site 282458001417 Predicted helix-turn-helix motif with score 1997 (+5.99 SD) at aa 18-39, sequence ISQRELAEAIGLSRPSVANIIS 282458001418 Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 99.60, E-value 6.2e-26 282458001419 PS00583 pfkB family of carbohydrate kinases signature 1. 282458001420 PS00584 pfkB family of carbohydrate kinases signature 2. 282458001421 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 282458001422 1 probable transmembrane helix predicted for SAR0309 by TMHMM2.0 at aa 104-126 282458001423 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 282458001424 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 282458001425 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 282458001426 Pfam match to entry PF01773 Nucleoside_tra2, Na+ dependent nucleoside transporter, score 433.40, E-value 2e-126 282458001427 8 probable transmembrane helices predicted for SAR0310 by TMHMM2.0 at aa 4-22, 34-56, 88-110, 192-211, 264-286, 293-315, 347-369 and 382-404 282458001428 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 282458001429 putative transporter; Provisional; Region: PRK10484 282458001430 Na binding site [ion binding]; other site 282458001431 13 probable transmembrane helices predicted for SAR0311 by TMHMM2.0 at aa 4-26, 46-68, 78-100, 121-143, 158-180, 187-205, 230-252, 279-301, 316-338, 373-395, 405-427, 432-449 and 459-481 282458001432 Pfam match to entry PF00474 SSF, Sodium:solute symporter family, score 38.60, E-value 3.7e-09 282458001433 N-acetylneuraminate lyase; Provisional; Region: PRK04147 282458001434 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 282458001435 inhibitor site; inhibition site 282458001436 active site 282458001437 dimer interface [polypeptide binding]; other site 282458001438 catalytic residue [active] 282458001439 Pfam match to entry PF00701 DHDPS, Dihydrodipicolinate synthetase, score 303.00, E-value 3.7e-87 282458001440 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 282458001441 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 282458001442 nucleotide binding site [chemical binding]; other site 282458001443 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 282458001444 Pfam match to entry PF00480 ROK, ROK family, score 65.40, E-value 2.3e-18 282458001445 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 282458001446 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 282458001447 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 282458001448 putative active site [active] 282458001449 Pfam match to entry PF01380 SIS, SIS domain, score 82.30, E-value 1e-20 282458001450 Predicted helix-turn-helix motif with score 996 (+2.58 SD) at aa 35-56, sequence STINSLAHAIGTSPATMTRFSH 282458001451 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 282458001452 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 282458001453 putative active site cavity [active] 282458001454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 282458001455 Nucleoside recognition; Region: Gate; pfam07670 282458001456 12 probable transmembrane helices predicted for SAR0316 by TMHMM2.0 at aa 12-31, 51-73, 80-102, 124-146, 167-186, 201-223, 230-252, 304-326, 331-348, 352-374, 381-403 and 413-435 282458001457 Signal peptide predicted for SAR0317 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.792 between residues 37 and 38; signal peptide 282458001458 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 282458001459 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 282458001460 PGAP1-like protein; Region: PGAP1; pfam07819 282458001461 PS00017 ATP/GTP-binding site motif A (P-loop). 282458001462 PS00120 Lipases, serine active site. 282458001463 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 282458001464 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 282458001465 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 282458001466 putative active site [active] 282458001467 putative FMN binding site [chemical binding]; other site 282458001468 putative substrate binding site [chemical binding]; other site 282458001469 putative catalytic residue [active] 282458001470 Pfam match to entry PF00724 oxidored_FMN, NADH:flavin oxidoreductase / NADH oxidase, score 177.40, E-value 2.4e-49 282458001471 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 282458001472 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 282458001473 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 282458001474 Pfam match to entry PF00296 bac_luciferase, Bacterial luciferase, score 53.00, E-value 6.4e-12 282458001475 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 282458001476 lipoyl attachment site [posttranslational modification]; other site 282458001477 Pfam match to entry PF01597 GCV_H, Glycine cleavage H-protein, score 27.50, E-value 2.5e-06 282458001478 Replication protein C N-terminal domain; Region: RP-C; pfam03428 282458001479 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 282458001480 putative ADP-ribose binding site [chemical binding]; other site 282458001481 Pfam match to entry PF01661 A1pp, Appr-1 -p processing enzyme family, score 108.70, E-value 1.1e-28 282458001482 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 282458001483 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 282458001484 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 282458001485 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 282458001486 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 282458001487 Pfam match to entry PF02539 Lipoate_A, Lipoate-protein ligase A, score 117.60, E-value 2.3e-31 282458001488 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 282458001489 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 282458001490 NADP binding site [chemical binding]; other site 282458001491 putative substrate binding site [chemical binding]; other site 282458001492 active site 282458001493 PS00152 ATP synthase alpha and beta subunits signature. 282458001494 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 282458001495 10 probable transmembrane helices predicted for SAR0326 by TMHMM2.0 at aa 7-29, 93-112, 119-141, 145-167, 224-246, 261-283, 315-337, 341-363, 370-392 and 407-440 282458001496 PS00017 ATP/GTP-binding site motif A (P-loop). 282458001497 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 282458001498 active site 282458001499 P-loop; other site 282458001500 phosphorylation site [posttranslational modification] 282458001501 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282458001502 active site 282458001503 phosphorylation site [posttranslational modification] 282458001504 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 96.00, E-value 7.3e-25 282458001505 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 282458001506 HTH domain; Region: HTH_11; pfam08279 282458001507 HTH domain; Region: HTH_11; pfam08279 282458001508 PRD domain; Region: PRD; pfam00874 282458001509 PRD domain; Region: PRD; pfam00874 282458001510 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 282458001511 active site 282458001512 P-loop; other site 282458001513 phosphorylation site [posttranslational modification] 282458001514 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282458001515 active site 282458001516 phosphorylation site [posttranslational modification] 282458001517 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 11.90, E-value 1.1e-06 282458001518 Pfam match to entry PF00874 BglG_antitermin, Transcriptional antiterminator bglG family, score 41.90, E-value 1.4e-08 282458001519 Pfam match to entry PF00874 BglG_antitermin, Transcriptional antiterminator bglG family, score 48.90, E-value 1.1e-10 282458001520 Predicted helix-turn-helix motif for SAR0329 with score 1440.000, SD 4.09 at aa 105-126, sequence VSTKQLAQDVNVSRRTIADDIK 282458001521 Predicted helix-turn-helix motif with score 1474 (+4.21 SD) at aa 20-41, sequence IPINTIANQLGVSPRTIQYDIA 282458001522 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 282458001523 MarR family; Region: MarR_2; pfam12802 282458001524 Pfam match to entry PF01047 MarR, MarR family, score 58.40, E-value 1.5e-13 282458001525 Predicted helix-turn-helix motif with score 1531 (+4.40 SD) at aa 48-69, sequence LTQNDIAKALQRTGPTVSNLLR 282458001526 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 282458001527 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 282458001528 12 probable transmembrane helices predicted for SAR0331 by TMHMM2.0 at aa 20-42, 52-74, 95-117, 132-154, 167-189, 194-216, 246-268, 283-305, 318-340, 355-377, 389-411 and 415-437 282458001529 Pfam match to entry PF01554 UPF0013, Uncharacterized membrane protein family UPF0013, score 94.90, E-value 1.6e-24 282458001530 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 282458001531 Pfam match to entry PF01554 UPF0013, Uncharacterized membrane protein family UPF0013, score 53.30, E-value 5.5e-12 282458001532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 282458001533 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 282458001534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458001535 putative substrate translocation pore; other site 282458001536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458001537 12 probable transmembrane helices predicted for SAR0333 by TMHMM2.0 at aa 27-44, 64-86, 93-115, 119-138, 159-181, 196-215, 261-280, 300-319, 331-348, 358-380, 393-415 and 420-442 282458001538 PS00942 glpT family of transporters signature. 282458001539 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 282458001540 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 282458001541 Zn binding site [ion binding]; other site 282458001542 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 282458001543 Zn binding site [ion binding]; other site 282458001544 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 44.30, E-value 1.6e-11 282458001545 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 15.10, E-value 0.0044 282458001546 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 282458001547 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 282458001548 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 282458001549 Pfam match to entry PF00296 bac_luciferase, Bacterial luciferase, score 69.50, E-value 7.2e-17 282458001550 Similar to Pseudomonas aeruginosa NADH-dependent FMN reductase MsuE SW:MSUE_PSEAE (O31038) (186 aa) fasta scores: E(): 1.4e-08, 28.313% id in 166 aa, and to Rhizobium loti NADH-dependent FMN reductase MsuE TR:BAB51711 (EMBL:AP003006) (186 aa) fasta scores: E(): 1.8e-07, 26.829% id in 164 aa. Contains a nonsense mutation (ochre) after codon 45;NADH-dependent FMN reductase (pseudogene) 282458001551 Predicted membrane protein [Function unknown]; Region: COG2855 282458001552 Signal peptide predicted for SAR0338 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.527 between residues 37 and 38; signal peptide 282458001553 11 probable transmembrane helices predicted for SAR0338 by TMHMM2.0 at aa 9-26, 31-48, 69-88, 93-115, 122-144, 154-176, 183-202, 217-234, 247-269, 273-295 and 308-330 282458001554 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 282458001555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 282458001556 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 54.60, E-value 2.1e-12 282458001557 Signal peptide predicted for SAR0340 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.666 between residues 25 and 26; signal peptide 282458001558 Imelysin; Region: Peptidase_M75; pfam09375 282458001559 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458001560 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 282458001561 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 282458001562 1 probable transmembrane helix predicted for SAR0341 by TMHMM2.0 at aa 21-40 282458001563 Signal peptide predicted for SAR0342 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.857 between residues 28 and 29; signal peptide 282458001564 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 282458001565 7 probable transmembrane helices predicted for SAR0342 by TMHMM2.0 at aa 5-24, 355-377, 392-409, 430-449, 469-491, 498-520 and 551-568 282458001566 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 282458001567 6 probable transmembrane helices predicted for SAR0343 by TMHMM2.0 at aa 12-34, 58-80, 100-122, 142-164, 184-201 and 205-222 282458001568 Pfam match to entry PF00902 UPF0032, MttB family UPF0032, score 145.00, E-value 1.4e-39 282458001569 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 282458001570 Pfam match to entry PF02416 MttA_Hcf106, mttA/Hcf106 family, score 71.80, E-value 1.5e-17 282458001571 1 probable transmembrane helix predicted for SAR0344 by TMHMM2.0 at aa 5-27 282458001572 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 282458001573 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282458001574 non-specific DNA binding site [nucleotide binding]; other site 282458001575 salt bridge; other site 282458001576 sequence-specific DNA binding site [nucleotide binding]; other site 282458001577 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 57.70, E-value 2.6e-13 282458001578 Predicted helix-turn-helix motif with score 2314 (+7.07 SD) at aa 14-35, sequence LNQTQLAKQAGVSRQTISLIER 282458001579 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 282458001580 6 probable transmembrane helices predicted for SAR0347 by TMHMM2.0 at aa 7-29, 44-63, 95-117, 127-146, 187-209 and 213-231 282458001581 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 282458001582 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 282458001583 Walker A/P-loop; other site 282458001584 ATP binding site [chemical binding]; other site 282458001585 Q-loop/lid; other site 282458001586 ABC transporter signature motif; other site 282458001587 Walker B; other site 282458001588 D-loop; other site 282458001589 H-loop/switch region; other site 282458001590 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 148.80, E-value 9.2e-41 282458001591 PS00017 ATP/GTP-binding site motif A (P-loop). 282458001592 Signal peptide predicted for SAR0349 by SignalP 2.0 HMM (Signal peptide probabilty 0.813) with cleavage site probability 0.764 between residues 40 and 41; signal peptide 282458001593 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 282458001594 5 probable transmembrane helices predicted for SAR0349 by TMHMM2.0 at aa 15-37, 80-102, 106-128, 140-162 and 177-199 282458001595 Predicted membrane protein [Function unknown]; Region: COG4292 282458001596 12 probable transmembrane helices predicted for SAR0350 by TMHMM2.0 at aa 20-39, 49-71, 84-101, 106-128, 141-163, 168-190, 202-224, 229-248, 260-282, 297-319, 326-344 and 349-367 282458001597 putative acyltransferase; Provisional; Region: PRK05790 282458001598 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 282458001599 dimer interface [polypeptide binding]; other site 282458001600 active site 282458001601 Pfam match to entry PF00108 thiolase, Thiolase, N-terminal domain, score 538.10, E-value 6.1e-158 282458001602 PS00098 Thiolases acyl-enzyme intermediate signature. 282458001603 Pfam match to entry PF02803 thiolase_C, Thiolase, C-terminal domain, score 224.00, E-value 2.1e-63 282458001604 PS00737 Thiolases signature 2. 282458001605 PS00099 Thiolases active site. 282458001606 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 282458001607 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 282458001608 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 282458001609 THF binding site; other site 282458001610 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 282458001611 substrate binding site [chemical binding]; other site 282458001612 THF binding site; other site 282458001613 zinc-binding site [ion binding]; other site 282458001614 Pfam match to entry PF01717 Methionine_synt, Methionine synthase, vitamin-B12 independent, score 602.90, E-value 1.9e-177 282458001615 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 282458001616 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 282458001617 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 282458001618 FAD binding site [chemical binding]; other site 282458001619 Pfam match to entry PF02219 MTHFR, Methylenetetrahydrofolate reductase, score -42.00, E-value 5.2e-09 282458001620 Pfam match to entry PF02574 S-methyl_trans, Homocysteine S-methyltransferase, score 202.40, E-value 6.8e-57 282458001621 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 282458001622 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 282458001623 homodimer interface [polypeptide binding]; other site 282458001624 substrate-cofactor binding pocket; other site 282458001625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458001626 catalytic residue [active] 282458001627 Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme, score 546.40, E-value 2e-160 282458001628 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 282458001629 cystathionine gamma-synthase; Reviewed; Region: PRK08247 282458001630 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 282458001631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282458001632 catalytic residue [active] 282458001633 Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme, score 475.40, E-value 4.6e-139 282458001634 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 282458001635 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 282458001636 ParB-like nuclease domain; Region: ParB; smart00470 282458001637 Pfam match to entry PF02195 ParBc, ParB-like nuclease domain, score 130.50, E-value 3e-35 282458001638 Predicted helix-turn-helix motif with score 1788 (+5.28 SD) at aa 133-154, sequence ITQQEVAKRLSKSRPYIANMLR 282458001639 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 282458001640 Mechanosensitive ion channel; Region: MS_channel; pfam00924 282458001641 3 probable transmembrane helices predicted for SAR0358 by TMHMM2.0 at aa 20-42, 69-91 and 101-120 282458001642 Pfam match to entry PF00924 MS_channel, Uncharacterized protein family UPF0003, score 169.30, E-value 6.3e-47 282458001643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 282458001644 GTP-binding protein YchF; Reviewed; Region: PRK09601 282458001645 YchF GTPase; Region: YchF; cd01900 282458001646 G1 box; other site 282458001647 GTP/Mg2+ binding site [chemical binding]; other site 282458001648 Switch I region; other site 282458001649 G2 box; other site 282458001650 Switch II region; other site 282458001651 G3 box; other site 282458001652 G4 box; other site 282458001653 G5 box; other site 282458001654 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 282458001655 Pfam match to entry PF01018 GTP1_OBG, GTP1/OBG family, score 21.20, E-value 7.3e-05 282458001656 PS00017 ATP/GTP-binding site motif A (P-loop). 282458001657 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 282458001658 Pfam match to entry PF01250 Ribosomal_S6, Ribosomal protein S6, score 131.60, E-value 1.4e-35 282458001659 PS01048 Ribosomal protein S6 signature. 282458001660 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 282458001661 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 282458001662 dimer interface [polypeptide binding]; other site 282458001663 ssDNA binding site [nucleotide binding]; other site 282458001664 tetramer (dimer of dimers) interface [polypeptide binding]; other site 282458001665 Pfam match to entry PF00436 SSB, Single-strand binding protein family, score 186.40, E-value 1.4e-54 282458001666 PS00735 Single-strand binding protein family signature 1. 282458001667 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 282458001668 Pfam match to entry PF01084 Ribosomal_S18, Ribosomal protein S18, score 125.80, E-value 8.2e-34 282458001669 PS00057 Ribosomal protein S18 signature. 282458001670 pathogenicity island. Absent in N315, Mu50, Col and NCTC8325. Similar to SaPI1, SaPI3 and SaPIbov 282458001671 PemK-like protein; Region: PemK; pfam02452 282458001672 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 282458001673 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 282458001674 Int/Topo IB signature motif; other site 282458001675 Pfam match to entry PF00589 Phage_integrase, Phage integrase, score 132.80, E-value 6.4e-36 282458001676 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 282458001677 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282458001678 non-specific DNA binding site [nucleotide binding]; other site 282458001679 salt bridge; other site 282458001680 sequence-specific DNA binding site [nucleotide binding]; other site 282458001681 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 28.80, E-value 0.00013 282458001682 Predicted helix-turn-helix motif with score 1132 (+3.04 SD) at aa 25-46, sequence KTASEISKQMQYSQGHISGIEN 282458001683 Helix-turn-helix domain; Region: HTH_17; cl17695 282458001684 Predicted helix-turn-helix motif with score 1368 (+3.85 SD) at aa 21-42, sequence MTVKEVAQLLRISERHTYKLLQ 282458001685 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 282458001686 Signal peptide predicted for SAR0370 by SignalP 2.0 HMM (Signal peptide probabilty 0.962) with cleavage site probability 0.811 between residues 29 and 30; signal peptide 282458001687 1 probable transmembrane helix predicted for SAR0370 by TMHMM2.0 at aa 7-29 282458001688 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 282458001689 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 282458001690 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 282458001691 PS00017 ATP/GTP-binding site motif A (P-loop). 282458001692 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 282458001693 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 282458001694 Abi-like protein; Region: Abi_2; pfam07751 282458001695 Signal peptide predicted for SAR0385 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 33 and 34; signal peptide 282458001696 2 probable transmembrane helices predicted for SAR0385 by TMHMM2.0 at aa 121-143 and 147-169 282458001697 Abi-like protein; Region: Abi_2; pfam07751 282458001698 Probable gene remnant. Similar to the C-terminal regions of Bacteriophage L54a integrase Int SWALL:VINT_BPL54 (SWALL:P20709) (354 aa) fasta scores: E(): 3e-19, 39.06% id in 192 aa, and Staphylococcus aureus bacteriophage PVL, and Staphylococcus aureus temperate phage phiSLT integrase SWALL:O80068 (EMBL:AB009866) (401 aa) fasta scores: E(): 5e-20, 36.18% id in 199 aa. CDS contains several frameshift mutations. Similar to the C-terminal region of SAR0366;integrase (fragment) 282458001699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 282458001700 Signal peptide predicted for SAR0389 by SignalP 2.0 HMM (Signal peptide probabilty 0.616) with cleavage site probability 0.460 between residues 32 and 33; signal peptide 282458001701 1 probable transmembrane helix predicted for SAR0389 by TMHMM2.0 at aa 7-24 282458001702 Signal peptide predicted for SAR0390 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.578 between residues 20 and 21; signal peptide 282458001703 Predicted membrane protein [Function unknown]; Region: COG3212 282458001704 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 282458001705 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458001706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 282458001707 non-specific DNA binding site [nucleotide binding]; other site 282458001708 salt bridge; other site 282458001709 sequence-specific DNA binding site [nucleotide binding]; other site 282458001710 Predicted membrane protein [Function unknown]; Region: COG2261 282458001711 3 probable transmembrane helices predicted for SAR0392 by TMHMM2.0 at aa 4-23, 30-52 and 56-78 282458001712 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 282458001713 catalytic core [active] 282458001714 Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase, score 74.90, E-value 1.7e-18 282458001715 PS00175 Phosphoglycerate mutase phosphohistidine signature. 282458001716 Signal peptide predicted for SAR0395 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.391 between residues 35 and 36; signal peptide 282458001717 4 probable transmembrane helices predicted for SAR0395 by TMHMM2.0 at aa 7-24, 39-61, 68-90 and 95-117 282458001718 Signal peptide predicted for SAR0396 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.678 between residues 21 and 22; signal peptide 282458001719 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458001720 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 282458001721 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 282458001722 catalytic residue [active] 282458001723 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 282458001724 catalytic residues [active] 282458001725 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 282458001726 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282458001727 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 237.90, E-value 1.4e-67 282458001728 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 282458001729 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 282458001730 peroxiredoxin; Region: AhpC; TIGR03137 282458001731 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 282458001732 dimer interface [polypeptide binding]; other site 282458001733 decamer (pentamer of dimers) interface [polypeptide binding]; other site 282458001734 catalytic triad [active] 282458001735 peroxidatic and resolving cysteines [active] 282458001736 Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family, score 217.30, E-value 2.3e-61 282458001737 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 282458001738 dimer interface [polypeptide binding]; other site 282458001739 FMN binding site [chemical binding]; other site 282458001740 NADPH bind site [chemical binding]; other site 282458001741 Pfam match to entry PF00881 Nitroreductase, Nitroreductase, score 103.20, E-value 5e-27 282458001742 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 282458001743 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 282458001744 Pfam match to entry PF00375 SDF, Sodium:dicarboxylate symporter family, score 282.80, E-value 4.5e-81 282458001745 9 probable transmembrane helices predicted for SAR0401 by TMHMM2.0 at aa 4-21, 34-56, 71-93, 105-127, 180-202, 222-244, 264-286, 368-390 and 394-416 282458001746 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 282458001747 Predicted helix-turn-helix motif with score 1266 (+3.50 SD) at aa 1-22, sequence MLTKEFAQRVELSEKQVRKIVQ 282458001748 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282458001749 active site 282458001750 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 55.10, E-value 1.6e-12 282458001751 xanthine permease; Region: pbuX; TIGR03173 282458001752 Pfam match to entry PF00860 xan_ur_permease, Xanthine/uracil permeases family, score 421.50, E-value 7.6e-123 282458001753 13 probable transmembrane helices predicted for SAR0407 by TMHMM2.0 at aa 10-29, 36-55, 59-81, 88-107, 117-139, 152-171, 176-195, 215-237, 268-290, 303-325, 329-351, 358-380 and 390-412 282458001754 PS01116 Xanthine/uracil permeases family signature. 282458001755 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 282458001756 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 282458001757 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 282458001758 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 282458001759 active site 282458001760 Pfam match to entry PF01574 IMPDH_N, IMP dehydrogenase / GMP reductase N terminus, score 195.60, E-value 7.9e-55 282458001761 Pfam match to entry PF00571 CBS, CBS domain, score 50.30, E-value 4.2e-11 282458001762 Pfam match to entry PF00571 CBS, CBS domain, score 57.10, E-value 3.7e-13 282458001763 Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus, score 379.70, E-value 3e-110 282458001764 PS00487 IMP dehydrogenase / GMP reductase signature. 282458001765 GMP synthase; Reviewed; Region: guaA; PRK00074 282458001766 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 282458001767 AMP/PPi binding site [chemical binding]; other site 282458001768 candidate oxyanion hole; other site 282458001769 catalytic triad [active] 282458001770 potential glutamine specificity residues [chemical binding]; other site 282458001771 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 282458001772 ATP Binding subdomain [chemical binding]; other site 282458001773 Ligand Binding sites [chemical binding]; other site 282458001774 Dimerization subdomain; other site 282458001775 Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I, score 211.50, E-value 1.3e-59 282458001776 Pfam match to entry PF00958 GMP_synt_C, GMP synthase C terminal domain, score 238.30, E-value 1.1e-67 282458001777 Poor database matches. Similar to Staphylococcus aureus subsp aureus N315 hypothetical protein SA0378 TR:Q99WI6 (EMBL:AP003130) (234 aa) fasta scores: E(): 4.9e-77, 98.291% id in 234 aa, and to Streptococcus pyogenes hypothetical P protein SPY0938 TR:Q9A043 (EMBL:AE006542) (269 aa) fasta scores: E(): 2.9e-07, 28.788% id in 264 aa. Contains a frameshift after codon 129. Frameshift occurs at a poly A octamer;conserved hypothetical protein (pseudogene) 282458001778 Poor database matches. Similar to C-terminal region of Staphylococcus aureus mobile pathogenicity island protein Orf16 TR:Q9F0K2 (EMBL:AF217235) (105 aa) fasta scores: E(): 0.0018, 65.714% id in 35 aa;hypothetical protein (fragment) 282458001779 Poor database matches. Similar to an internal region of Staphylococcus aureus mobile pathogenicity island protein Orf13 TR:O54473 (EMBL:U93688) (95 aa) fasta scores: E(): 1e-05, 56.410% id in 39 aa. Contains a frameshift. Possible gene remnant. Similar to internal region of SAR0374 73.333% identity (73.333% ungapped) in 30 aa overlap;hypothetical protein (fragment) 282458001780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 282458001781 Transposase; Region: HTH_Tnp_1; pfam01527 282458001782 Predicted helix-turn-helix motif for SAR0416 with score 1046.000, SD 2.75 at aa 32-53, sequence KPKNEIIREYDLTTSTFSNPIK 282458001783 Predicted membrane protein [Function unknown]; Region: COG3759 282458001784 3 probable transmembrane helices predicted for SAR0420 by TMHMM2.0 at aa 4-22, 50-72 and 82-104 282458001785 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 282458001786 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 282458001787 NADP binding site [chemical binding]; other site 282458001788 superantigen-like protein; Reviewed; Region: PRK13037 282458001789 Signal peptide predicted for SAR0422 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.992 between residues 30 and 31; signal peptide 282458001790 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282458001791 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458001792 superantigen-like protein; Reviewed; Region: PRK13041 282458001793 Signal peptide predicted for SAR0423 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 30 and 31; signal peptide 282458001794 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282458001795 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458001796 superantigen-like protein; Reviewed; Region: PRK13335 282458001797 Signal peptide predicted for SAR0424 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.876 between residues 30 and 31; signal peptide 282458001798 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282458001799 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458001800 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -0.80, E-value 0.0047 282458001801 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458001802 superantigen-like protein; Reviewed; Region: PRK13042 282458001803 Signal peptide predicted for SAR0425 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.906 between residues 30 and 31; signal peptide 282458001804 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282458001805 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458001806 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -12.10, E-value 0.041 282458001807 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458001808 superantigen-like protein 5; Reviewed; Region: PRK13035 282458001809 Signal peptide predicted for SAR0427 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.893 between residues 30 and 31; signal peptide 282458001810 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282458001811 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458001812 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -22.20, E-value 0.27 282458001813 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458001814 Signal peptide predicted for SAR0428 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.981 between residues 30 and 31; signal peptide 282458001815 superantigen-like protein 7; Reviewed; Region: PRK13346 282458001816 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282458001817 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458001818 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 12.10, E-value 0.00041 282458001819 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458001820 Signal peptide predicted for SAR0429 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.830 between residues 30 and 31; signal peptide 282458001821 superantigen-like protein; Reviewed; Region: PRK13345 282458001822 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282458001823 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458001824 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 13.10, E-value 0.00034 282458001825 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458001826 Signal peptide predicted for SAR0431 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.446 between residues 27 and 28; signal peptide 282458001827 superantigen-like protein; Reviewed; Region: PRK13038 282458001828 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282458001829 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458001830 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 0.70, E-value 0.0036 282458001831 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458001832 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 282458001833 HsdM N-terminal domain; Region: HsdM_N; pfam12161 282458001834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458001835 S-adenosylmethionine binding site [chemical binding]; other site 282458001836 Pfam match to entry PF02506 Methylase_M, Type I restriction modification system, M protein, score 272.10, E-value 7.2e-78 282458001837 PS00092 N-6 Adenine-specific DNA methylases signature. 282458001838 Pfam match to entry PF02384 N6_Mtase, N-6 DNA Methylase, score 262.00, E-value 8e-75 282458001839 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 282458001840 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 282458001841 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 282458001842 Pfam match to entry PF01420 Methylase_S, Type I restriction modification DNA specificity domain, score 42.90, E-value 3.3e-11 282458001843 Pfam match to entry PF01420 Methylase_S, Type I restriction modification DNA specificity domain, score 23.60, E-value 1.2e-05 282458001844 superantigen-like protein; Reviewed; Region: PRK13036 282458001845 Signal peptide predicted for SAR0435 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 30 and 31; signal peptide 282458001846 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282458001847 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458001848 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -3.90, E-value 0.0086 282458001849 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458001850 Signal peptide predicted for SAR0436 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.684 between residues 32 and 33; signal peptide 282458001851 Signal peptide predicted for SAR0437 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.780 between residues 29 and 30; signal peptide 282458001852 Signal peptide predicted for SAR0438 by SignalP 2.0 HMM (Signal peptide probabilty 0.966) with cleavage site probability 0.481 between residues 27 and 28; signal peptide 282458001853 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282458001854 1 probable transmembrane helix predicted for SAR0438 by TMHMM2.0 at aa 7-25 282458001855 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458001856 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282458001857 Signal peptide predicted for SAR0439 by SignalP 2.0 HMM (Signal peptide probabilty 0.919) with cleavage site probability 0.358 between residues 26 and 27; signal peptide 282458001858 1 probable transmembrane helix predicted for SAR0439 by TMHMM2.0 at aa 7-24 282458001859 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458001860 No significant database matches. Contains a frameshift after codon 136. Similar to SAR0438, 72.61% identity in 248 aa overlap, SAR0442, 61.0% identity in 254 aa overlap, SAR0443, 61.0% identity in 254 aa overlap, and SAR0443, 67.3% identity in 254 aa overlap; lipoprotein (pseudogene) 282458001861 Signal peptide predicted for SAR0440 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.454 between residues 33 and 34 282458001862 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458001863 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282458001864 Signal peptide predicted for SAR0442 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.865 between residues 31 and 32; signal peptide 282458001865 1 probable transmembrane helix predicted for SAR0442 by TMHMM2.0 at aa 7-29 282458001866 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282458001867 Signal peptide predicted for SAR0443 by SignalP 2.0 HMM (Signal peptide probabilty 0.811) with cleavage site probability 0.395 between residues 26 and 27; signal peptide 282458001868 1 probable transmembrane helix predicted for SAR0443 by TMHMM2.0 at aa 7-24 282458001869 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458001870 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282458001871 Signal peptide predicted for SAR0444 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.671 between residues 31 and 32; signal peptide 282458001872 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458001873 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282458001874 1 probable transmembrane helix predicted for SAR0445 by TMHMM2.0 at aa 7-24 282458001875 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458001876 Similar to Staphylococcus aureus hypothetical protein MW0402 SWALL:Q8NY34 (EMBL:AP004823) (441 aa) fasta scores: E(): 2.1e-133, 91.36% id in 440 aa, and to Staphylococcus aureus hypothetical protein MW0074 SWALL:Q8NYT9 (EMBL:AP004822) (458 aa) fasta scores: E(): 8.4e-29, 42.7% id in 459 aa. CDS contains a frameshift after codon 6. Frameshift possibly occurs at a poly A hexamer;hypothetical protein (pseudogene) 282458001877 Signal peptide predicted for SAR0449 by SignalP 2.0 HMM (Signal peptide probabilty 0.898) with cleavage site probability 0.314 between residues 28 and 29; signal peptide 282458001878 2 probable transmembrane helices predicted for SAR0449 by TMHMM2.0 at aa 4-21 and 34-56 282458001879 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 282458001880 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 282458001881 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 282458001882 PS00017 ATP/GTP-binding site motif A (P-loop). 282458001883 Pfam match to entry PF02492 cobW, Cobalamin synthesis protein/P47K, score 426.10, E-value 3.1e-124 282458001884 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 282458001885 Signal peptide predicted for SAR0452 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.396 between residues 26 and 27; signal peptide 282458001886 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 282458001887 14 probable transmembrane helices predicted for SAR0452 by TMHMM2.0 at aa 7-29, 34-56, 69-86, 101-118, 125-142, 157-179, 191-213, 228-247, 254-276, 291-313, 343-365, 369-386, 398-420 and 435-457 282458001888 Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 172.80, E-value 5.8e-48 282458001889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 282458001890 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 282458001891 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 282458001892 4 probable transmembrane helices predicted for SAR0455 by TMHMM2.0 at aa 10-29, 36-54, 64-83 and 88-110 282458001893 Signal peptide predicted for SAR0456 by SignalP 2.0 HMM (Signal peptide probabilty 0.887) with cleavage site probability 0.558 between residues 29 and 30; signal peptide 282458001894 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 282458001895 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 282458001896 active site 282458001897 6 probable transmembrane helices predicted for SAR0456 by TMHMM2.0 at aa 13-32, 74-93, 98-116, 144-161, 168-190 and 195-217 282458001898 Pfam match to entry PF01569 PAP2, PAP2 superfamily, score 59.40, E-value 7.6e-14 282458001899 Esterase/lipase [General function prediction only]; Region: COG1647 282458001900 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 282458001901 Signal peptide predicted for SAR0458 by SignalP 2.0 HMM (Signal peptide probabilty 0.730) with cleavage site probability 0.246 between residues 23 and 24; signal peptide 282458001902 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 282458001903 Na2 binding site [ion binding]; other site 282458001904 putative substrate binding site 1 [chemical binding]; other site 282458001905 Na binding site 1 [ion binding]; other site 282458001906 putative substrate binding site 2 [chemical binding]; other site 282458001907 Pfam match to entry PF00209 SNF, Sodium:neurotransmitter symporter family, score 43.40, E-value 3.6e-11 282458001908 11 probable transmembrane helices predicted for SAR0458 by TMHMM2.0 at aa 13-30, 45-67, 94-116, 144-166, 179-198, 218-240, 253-275, 303-325, 344-366, 381-403 and 423-445 282458001909 Pfam match to entry PF00209 SNF, Sodium:neurotransmitter symporter family, score 59.50, E-value 1.4e-15 282458001910 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 282458001911 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 282458001912 dimer interface [polypeptide binding]; other site 282458001913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458001914 catalytic residue [active] 282458001915 Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme, score 298.60, E-value 7.5e-86 282458001916 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 282458001917 cystathionine beta-lyase; Provisional; Region: PRK07671 282458001918 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 282458001919 homodimer interface [polypeptide binding]; other site 282458001920 substrate-cofactor binding pocket; other site 282458001921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458001922 catalytic residue [active] 282458001923 Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme, score 662.80, E-value 1.7e-195 282458001924 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 282458001925 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 282458001926 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 282458001927 Walker A/P-loop; other site 282458001928 ATP binding site [chemical binding]; other site 282458001929 Q-loop/lid; other site 282458001930 ABC transporter signature motif; other site 282458001931 Walker B; other site 282458001932 D-loop; other site 282458001933 H-loop/switch region; other site 282458001934 NIL domain; Region: NIL; pfam09383 282458001935 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 227.20, E-value 2.4e-64 282458001936 PS00017 ATP/GTP-binding site motif A (P-loop). 282458001937 PS00211 ABC transporters family signature. 282458001938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458001939 dimer interface [polypeptide binding]; other site 282458001940 conserved gate region; other site 282458001941 ABC-ATPase subunit interface; other site 282458001942 5 probable transmembrane helices predicted for SAR0462 by TMHMM2.0 at aa 20-42, 62-79, 83-105, 148-170 and 190-212 282458001943 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 52.50, E-value 9.6e-12 282458001944 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282458001945 Signal peptide predicted for SAR0463 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.271 between residues 25 and 26; signal peptide 282458001946 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 282458001947 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 282458001948 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458001949 Signal peptide predicted for SAR0464 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 25 and 26; signal peptide 282458001950 LysM domain; Region: LysM; pfam01476 282458001951 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282458001952 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282458001953 Surface antigen [General function prediction only]; Region: COG3942 282458001954 CHAP domain; Region: CHAP; pfam05257 282458001955 Pfam match to entry PF01476 LysM, LysM domain, score 73.30, E-value 5e-18 282458001956 Pfam match to entry PF01476 LysM, LysM domain, score 70.60, E-value 3.2e-17 282458001957 Pfam match to entry PF01476 LysM, LysM domain, score 70.30, E-value 4.1e-17 282458001958 1 probable transmembrane helix predicted for SAR0465 by TMHMM2.0 at aa 36-55 282458001959 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 282458001960 nudix motif; other site 282458001961 Pfam match to entry PF00293 NUDIX, MutT-like domain, score 47.30, E-value 3.4e-10 282458001962 PS00893 mutT domain signature. 282458001963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458001964 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 282458001965 Coenzyme A binding pocket [chemical binding]; other site 282458001966 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 42.90, E-value 7.3e-09 282458001967 Signal peptide predicted for SAR0468 by SignalP 2.0 HMM (Signal peptide probabilty 0.639) with cleavage site probability 0.370 between residues 20 and 21; signal peptide 282458001968 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 282458001969 7 probable transmembrane helices predicted for SAR0468 by TMHMM2.0 at aa 4-19, 24-46, 50-72, 79-101, 116-138, 180-202 and 222-244 282458001970 Signal peptide predicted for SAR0469 by SignalP 2.0 HMM (Signal peptide probabilty 0.980) with cleavage site probability 0.295 between residues 39 and 40; signal peptide 282458001971 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 282458001972 8 probable transmembrane helices predicted for SAR0469 by TMHMM2.0 at aa 13-32, 127-144, 151-170, 175-197, 204-226, 248-270, 300-322 and 342-364 282458001973 Transcriptional regulator [Transcription]; Region: LysR; COG0583 282458001974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 282458001975 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 282458001976 dimerization interface [polypeptide binding]; other site 282458001977 Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 113.80, E-value 3.2e-30 282458001978 PS00044 Bacterial regulatory proteins, lysR family signature. 282458001979 Predicted helix-turn-helix motif with score 1683 (+4.92 SD) at aa 16-37, sequence EHISETALELNIAQSAISRQIT 282458001980 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 282458001981 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 282458001982 active site 282458001983 dimer interface [polypeptide binding]; other site 282458001984 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 282458001985 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 282458001986 active site 282458001987 FMN binding site [chemical binding]; other site 282458001988 substrate binding site [chemical binding]; other site 282458001989 3Fe-4S cluster binding site [ion binding]; other site 282458001990 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 282458001991 domain interface; other site 282458001992 Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase, score 757.60, E-value 5.3e-224 282458001993 Pfam match to entry PF01493 DUF14, Domain of unknown function DUF14, score 219.10, E-value 6.5e-62 282458001994 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 282458001995 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 282458001996 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 72.70, E-value 7.9e-18 282458001997 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 282458001998 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282458001999 active site turn [active] 282458002000 phosphorylation site [posttranslational modification] 282458002001 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282458002002 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 67.30, E-value 6.3e-18 282458002003 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282458002004 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 156.60, E-value 4.3e-43 282458002005 9 probable transmembrane helices predicted for SAR0473 by TMHMM2.0 at aa 113-135, 155-174, 181-203, 266-288, 301-323, 338-360, 373-395, 400-422 and 439-461 282458002006 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 282458002007 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 282458002008 Ca binding site [ion binding]; other site 282458002009 active site 282458002010 catalytic site [active] 282458002011 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 282458002012 Pfam match to entry PF00128 alpha-amylase, Alpha amylase, catalytic domain, score 452.20, E-value 4.5e-132 282458002013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 282458002014 DNA-binding site [nucleotide binding]; DNA binding site 282458002015 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 282458002016 UTRA domain; Region: UTRA; pfam07702 282458002017 Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 58.40, E-value 1.7e-16 282458002018 similar to hypothetical protein; Doubtful CDS. No database matches 282458002019 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 282458002020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458002021 Coenzyme A binding pocket [chemical binding]; other site 282458002022 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 46.70, E-value 5.2e-10 282458002023 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 282458002024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458002025 Walker A motif; other site 282458002026 ATP binding site [chemical binding]; other site 282458002027 Walker B motif; other site 282458002028 arginine finger; other site 282458002029 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA), score 43.50, E-value 4.7e-09 282458002030 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002031 PS00190 Cytochrome c family heme-binding site signature. 282458002032 PS00214 Cytosolic fatty-acid binding proteins signature. 282458002033 hypothetical protein; Validated; Region: PRK00153 282458002034 Pfam match to entry PF02575 DUF149, Uncharacterized BCR, YbaB family COG0718, score 128.50, E-value 1.2e-34 282458002035 recombination protein RecR; Reviewed; Region: recR; PRK00076 282458002036 RecR protein; Region: RecR; pfam02132 282458002037 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 282458002038 putative active site [active] 282458002039 putative metal-binding site [ion binding]; other site 282458002040 tetramer interface [polypeptide binding]; other site 282458002041 Pfam match to entry PF02132 RecR, RecR protein, score 75.40, E-value 1.2e-18 282458002042 PS01300 RecR protein signature. 282458002043 Pfam match to entry PF01751 Toprim, Toprim domain, score 61.60, E-value 1.7e-14 282458002044 insertion sequence ISY 282458002045 HTH-like domain; Region: HTH_21; pfam13276 282458002046 Integrase core domain; Region: rve; pfam00665 282458002047 Integrase core domain; Region: rve_3; cl15866 282458002048 Pfam match to entry PF00665 rve, Integrase core domain, score 95.20, E-value 2.4e-26 282458002049 Transposase; Region: HTH_Tnp_1; cl17663 282458002050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 282458002051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 282458002052 Helix-turn-helix domain; Region: HTH_28; pfam13518 282458002053 Pfam match to entry PF01527 Transposase_8, Transposase, score 47.20, E-value 3.6e-10 282458002054 insertion sequence ISZ 282458002055 Predicted helix-turn-helix motif with score 2127 (+6.43 SD) at aa 155-176, sequence QSYREVAEHFNISYGQIYQWVH 282458002056 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 282458002057 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 282458002058 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282458002059 catalytic residue [active] 282458002060 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 282458002061 Pfam match to entry PF01276 OKR_DC_1, Orn/Lys/Arg decarboxylase, score 76.20, E-value 1.3e-20 282458002062 thymidylate kinase; Validated; Region: tmk; PRK00698 282458002063 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 282458002064 TMP-binding site; other site 282458002065 ATP-binding site [chemical binding]; other site 282458002066 Pfam match to entry PF02223 Thymidylate_kin, Thymidylate kinase, score 217.80, E-value 1.6e-61 282458002067 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002068 PS01331 Thymidylate kinase signature. 282458002069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 282458002070 DNA polymerase III subunit delta'; Validated; Region: PRK08058 282458002071 DNA polymerase III subunit delta'; Validated; Region: PRK08485 282458002072 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 282458002073 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 282458002074 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 282458002075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458002076 S-adenosylmethionine binding site [chemical binding]; other site 282458002077 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 282458002078 GIY-YIG motif/motif A; other site 282458002079 putative active site [active] 282458002080 putative metal binding site [ion binding]; other site 282458002081 Predicted methyltransferases [General function prediction only]; Region: COG0313 282458002082 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 282458002083 putative SAM binding site [chemical binding]; other site 282458002084 putative homodimer interface [polypeptide binding]; other site 282458002085 Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases., score 147.30, E-value 2.6e-40 282458002086 PS01296 Uncharacterized protein family UPF0011 signature. 282458002087 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 282458002088 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 282458002089 active site 282458002090 HIGH motif; other site 282458002091 KMSKS motif; other site 282458002092 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 282458002093 tRNA binding surface [nucleotide binding]; other site 282458002094 anticodon binding site; other site 282458002095 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 282458002096 dimer interface [polypeptide binding]; other site 282458002097 putative tRNA-binding site [nucleotide binding]; other site 282458002098 Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V), score -104.80, E-value 3.7e-11 282458002099 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282458002100 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002101 Pfam match to entry PF01588 tRNA_bind, tRNA binding domain, score 117.70, E-value 2.2e-31 282458002102 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 282458002103 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 282458002104 active site 282458002105 PS01137 Uncharacterized protein family UPF0006 signature 1. 282458002106 Pfam match to entry PF01026 TatD_DNase, TatD related DNase, score 370.10, E-value 2.3e-107 282458002107 PS01091 Uncharacterized protein family UPF0006 signature 3. 282458002108 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 282458002109 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 282458002110 putative active site [active] 282458002111 putative metal binding site [ion binding]; other site 282458002112 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 282458002113 Pfam match to entry PF01751 Toprim, Toprim domain, score 30.40, E-value 4.2e-05 282458002114 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 282458002115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458002116 S-adenosylmethionine binding site [chemical binding]; other site 282458002117 Pfam match to entry PF00398 RrnaAD, Ribosomal RNA adenine dimethylases, score 283.90, E-value 1.4e-87 282458002118 PS01131 Ribosomal RNA adenine dimethylases signature. 282458002119 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 282458002120 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 282458002121 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 282458002122 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 282458002123 pur operon repressor; Provisional; Region: PRK09213 282458002124 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 282458002125 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282458002126 active site 282458002127 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 87.70, E-value 2.3e-22 282458002128 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 282458002129 homotrimer interaction site [polypeptide binding]; other site 282458002130 putative active site [active] 282458002131 Pfam match to entry PF01042 UPF0076, YjgF family, score 210.80, E-value 2e-59 282458002132 PS01094 Uncharacterized protein family UPF0076 signature. 282458002133 regulatory protein SpoVG; Reviewed; Region: PRK13259 282458002134 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 282458002135 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 282458002136 Substrate binding site; other site 282458002137 Mg++ binding site; other site 282458002138 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 282458002139 active site 282458002140 substrate binding site [chemical binding]; other site 282458002141 CoA binding site [chemical binding]; other site 282458002142 Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase, score 34.50, E-value 3.1e-08 282458002143 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 18.60, E-value 0.15 282458002144 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 14.30, E-value 2.9 282458002145 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 11.60, E-value 19 282458002146 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 12.20, E-value 13 282458002147 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 4.70, E-value 2e+02 282458002148 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 3.80, E-value 2.5e+02 282458002149 PS00101 Hexapeptide-repeat containing-transferases signature. 282458002150 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 15.20, E-value 1.6 282458002151 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 282458002152 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 282458002153 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282458002154 active site 282458002155 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 282458002156 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 146.70, E-value 4e-40 282458002157 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 282458002158 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 282458002159 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 282458002160 5S rRNA interface [nucleotide binding]; other site 282458002161 CTC domain interface [polypeptide binding]; other site 282458002162 L16 interface [polypeptide binding]; other site 282458002163 Pfam match to entry PF01386 Ribosomal_L25p, Ribosomal L25p family, score 108.10, E-value 1.7e-28 282458002164 PS00591 Glycosyl hydrolases family 10 active site. 282458002165 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 282458002166 putative active site [active] 282458002167 catalytic residue [active] 282458002168 Pfam match to entry PF01195 Pept_tRNA_hydro, Peptidyl-tRNA hydrolase, score 279.60, E-value 4e-80 282458002169 PS01195 Peptidyl-tRNA hydrolase signature 1. 282458002170 PS01196 Peptidyl-tRNA hydrolase signature 2. 282458002171 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 282458002172 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 282458002173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282458002174 ATP binding site [chemical binding]; other site 282458002175 putative Mg++ binding site [ion binding]; other site 282458002176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282458002177 nucleotide binding region [chemical binding]; other site 282458002178 ATP-binding site [chemical binding]; other site 282458002179 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 282458002180 Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase, score 95.50, E-value 2.7e-29 282458002181 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002182 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 81.90, E-value 1.3e-20 282458002183 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 282458002184 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 282458002185 Pfam match to entry PF01943 Polysacc_synt, Polysaccharide biosynthesis protein, score 62.50, E-value 8.9e-15 282458002186 14 probable transmembrane helices predicted for SAR0505 by TMHMM2.0 at aa 7-29, 39-61, 82-104, 114-136, 157-174, 179-198, 219-238, 268-290, 311-330, 340-357, 370-392, 397-419, 432-454 and 459-481 282458002187 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 282458002188 putative SAM binding site [chemical binding]; other site 282458002189 putative homodimer interface [polypeptide binding]; other site 282458002190 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 282458002191 homodimer interface [polypeptide binding]; other site 282458002192 metal binding site [ion binding]; metal-binding site 282458002193 Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases., score 10.40, E-value 1.8e-06 282458002194 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 282458002195 RNA binding surface [nucleotide binding]; other site 282458002196 Pfam match to entry PF01479 S4, S4 domain, score 34.30, E-value 2.7e-06 282458002197 Signal peptide predicted for SAR0508 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.494 between residues 56 and 57; signal peptide 282458002198 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 282458002199 Septum formation initiator; Region: DivIC; pfam04977 282458002200 1 probable transmembrane helix predicted for SAR0508 by TMHMM2.0 at aa 34-53 282458002201 hypothetical protein; Provisional; Region: PRK08582 282458002202 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 282458002203 RNA binding site [nucleotide binding]; other site 282458002204 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 89.30, E-value 4.5e-23 282458002205 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 282458002206 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 282458002207 Ligand Binding Site [chemical binding]; other site 282458002208 TilS substrate C-terminal domain; Region: TilS_C; smart00977 282458002209 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 282458002210 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282458002211 active site 282458002212 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 103.10, E-value 5.3e-27 282458002213 Signal peptide predicted for SAR0512 by SignalP 2.0 HMM (Signal peptide probabilty 0.753) with cleavage site probability 0.375 between residues 25 and 26; signal peptide 282458002214 FtsH Extracellular; Region: FtsH_ext; pfam06480 282458002215 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 282458002216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458002217 Walker A motif; other site 282458002218 ATP binding site [chemical binding]; other site 282458002219 Walker B motif; other site 282458002220 arginine finger; other site 282458002221 Peptidase family M41; Region: Peptidase_M41; pfam01434 282458002222 2 probable transmembrane helices predicted for SAR0512 by TMHMM2.0 at aa 4-26 and 110-132 282458002223 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA), score 338.90, E-value 5.6e-98 282458002224 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002225 PS00674 AAA-protein family signature. 282458002226 Pfam match to entry PF01434 Peptidase_M41, Peptidase M41, score 427.40, E-value 1.3e-124 282458002227 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 282458002228 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 282458002229 dimerization interface [polypeptide binding]; other site 282458002230 domain crossover interface; other site 282458002231 redox-dependent activation switch; other site 282458002232 Pfam match to entry PF01430 HSP33, Hsp33 protein, score 495.60, E-value 3.8e-145 282458002233 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 282458002234 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 282458002235 dimer interface [polypeptide binding]; other site 282458002236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458002237 catalytic residue [active] 282458002238 Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme, score 434.10, E-value 1.3e-126 282458002239 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 282458002240 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 282458002241 dihydropteroate synthase; Region: DHPS; TIGR01496 282458002242 substrate binding pocket [chemical binding]; other site 282458002243 dimer interface [polypeptide binding]; other site 282458002244 inhibitor binding site; inhibition site 282458002245 PS00792 Dihydropteroate synthase signature 1. 282458002246 Pfam match to entry PF00809 DHPS, Dihydropteroate synthase, score 512.70, E-value 2.7e-150 282458002247 PS00793 Dihydropteroate synthase signature 2. 282458002248 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 282458002249 homooctamer interface [polypeptide binding]; other site 282458002250 active site 282458002251 Pfam match to entry PF02152 FolB, Dihydroneopterin aldolase, score 143.70, E-value 2.1e-40 282458002252 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 282458002253 catalytic center binding site [active] 282458002254 ATP binding site [chemical binding]; other site 282458002255 Pfam match to entry PF01288 HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK), score 202.60, E-value 7e-58 282458002256 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 282458002257 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 282458002258 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 282458002259 dimer interface [polypeptide binding]; other site 282458002260 putative anticodon binding site; other site 282458002261 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 282458002262 motif 1; other site 282458002263 active site 282458002264 motif 2; other site 282458002265 motif 3; other site 282458002266 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain, score 48.20, E-value 1.9e-10 282458002267 Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N), score 672.40, E-value 2.3e-198 282458002268 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 282458002269 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282458002270 insertion sequence ISY 282458002271 HTH-like domain; Region: HTH_21; pfam13276 282458002272 Integrase core domain; Region: rve; pfam00665 282458002273 Integrase core domain; Region: rve_3; cl15866 282458002274 Pfam match to entry PF00665 rve, Integrase core domain, score 95.20, E-value 2.4e-26 282458002275 Transposase; Region: HTH_Tnp_1; cl17663 282458002276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 282458002277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 282458002278 Helix-turn-helix domain; Region: HTH_28; pfam13518 282458002279 Pfam match to entry PF01527 Transposase_8, Transposase, score 45.80, E-value 9.4e-10 282458002280 insertion sequence ISZ 282458002281 Predicted helix-turn-helix motif with score 2127 (+6.43 SD) at aa 155-176, sequence QSYREVAEHFNISYGQIYQWVH 282458002282 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 282458002283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 282458002284 DNA-binding site [nucleotide binding]; DNA binding site 282458002285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 282458002286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458002287 homodimer interface [polypeptide binding]; other site 282458002288 catalytic residue [active] 282458002289 Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 41.90, E-value 2.1e-11 282458002290 Predicted helix-turn-helix motif with score 1366 (+3.84 SD) at aa 29-50, sequence YSKRQLSKHLSISQTTVEHAYQ 282458002291 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 282458002292 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 282458002293 active site 282458002294 multimer interface [polypeptide binding]; other site 282458002295 Pfam match to entry PF01680 SOR_SNZ, SOR/SNZ family, score 431.80, E-value 6e-126 282458002296 Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthase, score 22.40, E-value 1.9e-05 282458002297 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 282458002298 predicted active site [active] 282458002299 catalytic triad [active] 282458002300 Pfam match to entry PF01174 SNO, SNO glutamine amidotransferase, score 329.70, E-value 3.3e-95 282458002301 PS01236 Uncharacterized protein family UPF0030 signature. 282458002302 Signal peptide predicted for SAR0524 by SignalP 2.0 HMM (Signal peptide probabilty 0.715) with cleavage site probability 0.273 between residues 22 and 23; signal peptide 282458002303 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 282458002304 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 282458002305 Nucleoside recognition; Region: Gate; pfam07670 282458002306 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 282458002307 Pfam match to entry PF01773 Nucleoside_tra2, Na+ dependent nucleoside transporter, score 610.50, E-value 9.7e-180 282458002308 10 probable transmembrane helices predicted for SAR0524 by TMHMM2.0 at aa 4-22, 31-53, 90-109, 114-133, 167-189, 194-216, 251-273, 286-308, 346-368 and 381-403 282458002309 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 282458002310 Predicted helix-turn-helix motif with score 1132 (+3.04 SD) at aa 29-50, sequence IQRANIAQRFDCVPSQLNYVIK 282458002311 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 282458002312 UvrB/uvrC motif; Region: UVR; pfam02151 282458002313 Pfam match to entry PF02151 UVR, UvrB/uvrC motif, score 28.80, E-value 0.00013 282458002314 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 282458002315 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 282458002316 ADP binding site [chemical binding]; other site 282458002317 phosphagen binding site; other site 282458002318 substrate specificity loop; other site 282458002319 Pfam match to entry PF00217 ATP-gua_Ptrans, ATP:guanido phosphotransferase, C-terminal catalytic domain, score 75.40, E-value 6e-21 282458002320 PS00112 ATP:guanido phosphotransferases active site. 282458002321 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 282458002322 Clp amino terminal domain; Region: Clp_N; pfam02861 282458002323 Clp amino terminal domain; Region: Clp_N; pfam02861 282458002324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458002325 Walker A motif; other site 282458002326 ATP binding site [chemical binding]; other site 282458002327 Walker B motif; other site 282458002328 arginine finger; other site 282458002329 UvrB/uvrC motif; Region: UVR; pfam02151 282458002330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458002331 Walker A motif; other site 282458002332 ATP binding site [chemical binding]; other site 282458002333 Walker B motif; other site 282458002334 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 282458002335 Pfam match to entry PF02861 Clp_N, Clp amino terminal domain, score 73.50, E-value 4.4e-18 282458002336 Pfam match to entry PF02861 Clp_N, Clp amino terminal domain, score 70.40, E-value 3.7e-17 282458002337 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA), score 53.10, E-value 6.1e-12 282458002338 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002339 PS00870 Chaperonins clpA/B signature 1. 282458002340 Pfam match to entry PF02151 UVR, UvrB/uvrC motif, score 34.80, E-value 1.9e-06 282458002341 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA), score 5.60, E-value 0.001 282458002342 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002343 PS00871 Chaperonins clpA/B signature 2. 282458002344 DNA repair protein RadA; Provisional; Region: PRK11823 282458002345 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 282458002346 Walker A motif/ATP binding site; other site 282458002347 ATP binding site [chemical binding]; other site 282458002348 Walker B motif; other site 282458002349 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 282458002350 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002351 Signal peptide predicted for SAR0530 by SignalP 2.0 HMM (Signal peptide probabilty 0.781) with cleavage site probability 0.676 between residues 28 and 29; signal peptide 282458002352 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 282458002353 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 282458002354 putative active site [active] 282458002355 4 probable transmembrane helices predicted for SAR0530 by TMHMM2.0 at aa 7-29, 44-61, 82-104 and 114-133 282458002356 Pfam match to entry PF01938 TRAM, Domain of unknown function DUF90, score 15.50, E-value 0.17 282458002357 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 282458002358 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 282458002359 active site 282458002360 HIGH motif; other site 282458002361 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 282458002362 active site 282458002363 KMSKS motif; other site 282458002364 Pfam match to entry PF00749 tRNA-synt_1c, tRNA synthetases class I (E and Q), score 776.70, E-value 9.4e-230 282458002365 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282458002366 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 282458002367 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 282458002368 trimer interface [polypeptide binding]; other site 282458002369 active site 282458002370 substrate binding site [chemical binding]; other site 282458002371 CoA binding site [chemical binding]; other site 282458002372 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 6.20, E-value 1.3e+02 282458002373 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 21.90, E-value 0.015 282458002374 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 2.60, E-value 3.5e+02 282458002375 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 9.10, E-value 54 282458002376 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 282458002377 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 282458002378 active site 282458002379 HIGH motif; other site 282458002380 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 282458002381 KMSKS motif; other site 282458002382 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 282458002383 tRNA binding surface [nucleotide binding]; other site 282458002384 anticodon binding site; other site 282458002385 Pfam match to entry PF01406 tRNA-synt_1e, tRNA synthetases class I (C), score 715.80, E-value 1.9e-211 282458002386 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 282458002387 active site 282458002388 dimerization interface [polypeptide binding]; other site 282458002389 metal binding site [ion binding]; metal-binding site 282458002390 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 282458002391 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 282458002392 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 282458002393 Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase, score 197.20, E-value 2.5e-55 282458002394 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 282458002395 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 282458002396 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 282458002397 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 282458002398 DNA binding residues [nucleotide binding] 282458002399 Predicted helix-turn-helix motif with score 1274 (+3.53 SD) at aa 155-176, sequence YKPREIAQLMHVKEKVIYNAIQ 282458002400 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 282458002401 Pfam match to entry PF00471 Ribosomal_L33, Ribosomal protein L33, score 48.80, E-value 2.3e-11 282458002402 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 282458002403 Pfam match to entry PF00584 SecE, SecE/Sec61-gamma subunits of protein translocation complex, score 58.50, E-value 1.4e-13 282458002404 PS01067 Protein secE/sec61-gamma signature. 282458002405 1 probable transmembrane helix predicted for SAR0539 by TMHMM2.0 at aa 31-53 282458002406 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 282458002407 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 282458002408 putative homodimer interface [polypeptide binding]; other site 282458002409 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 282458002410 heterodimer interface [polypeptide binding]; other site 282458002411 homodimer interface [polypeptide binding]; other site 282458002412 Pfam match to entry PF02357 NusG, Transcription termination factor nusG, score 94.40, E-value 2.2e-24 282458002413 PS01014 Transcription termination factor nusG signature. 282458002414 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 282458002415 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 282458002416 23S rRNA interface [nucleotide binding]; other site 282458002417 L7/L12 interface [polypeptide binding]; other site 282458002418 putative thiostrepton binding site; other site 282458002419 L25 interface [polypeptide binding]; other site 282458002420 Pfam match to entry PF00298 Ribosomal_L11, Ribosomal protein L11, score 290.90, E-value 1.6e-83 282458002421 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00359 Ribosomal protein L11 signature. 282458002422 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 282458002423 mRNA/rRNA interface [nucleotide binding]; other site 282458002424 Pfam match to entry PF00687 Ribosomal_L1, Ribosomal protein L1p/L10e family, score 434.20, E-value 1.2e-126 282458002425 PS01199 Ribosomal protein L1 signature. 282458002426 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 282458002427 23S rRNA interface [nucleotide binding]; other site 282458002428 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 282458002429 Pfam match to entry PF00466 Ribosomal_L10, Ribosomal protein L10, score 132.40, E-value 8.4e-36 282458002430 PS01109 Ribosomal protein L10 signature. 282458002431 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 282458002432 peripheral dimer interface [polypeptide binding]; other site 282458002433 core dimer interface [polypeptide binding]; other site 282458002434 L10 interface [polypeptide binding]; other site 282458002435 L11 interface [polypeptide binding]; other site 282458002436 putative EF-Tu interaction site [polypeptide binding]; other site 282458002437 putative EF-G interaction site [polypeptide binding]; other site 282458002438 Pfam match to entry PF00542 Ribosomal_L12, Ribosomal protein L7/L12 C-terminal domain, score 133.50, E-value 3.9e-36 282458002439 Methyltransferase domain; Region: Methyltransf_31; pfam13847 282458002440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458002441 S-adenosylmethionine binding site [chemical binding]; other site 282458002442 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 282458002443 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 282458002444 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 282458002445 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 282458002446 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 282458002447 RPB10 interaction site [polypeptide binding]; other site 282458002448 RPB1 interaction site [polypeptide binding]; other site 282458002449 RPB11 interaction site [polypeptide binding]; other site 282458002450 RPB3 interaction site [polypeptide binding]; other site 282458002451 RPB12 interaction site [polypeptide binding]; other site 282458002452 Pfam match to entry PF00562 RNA_pol_B, RNA polymerase beta subunit, score 264.50, E-value 1.5e-75 282458002453 Pfam match to entry PF00562 RNA_pol_B, RNA polymerase beta subunit, score 1473.20, E-value 0 282458002454 PS01166 RNA polymerases beta chain signature. 282458002455 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002456 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 282458002457 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 282458002458 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 282458002459 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 282458002460 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 282458002461 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 282458002462 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 282458002463 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 282458002464 G-loop; other site 282458002465 DNA binding site [nucleotide binding] 282458002466 Pfam match to entry PF00623 RNA_pol_A, RNA polymerase alpha subunit, score 948.10, E-value 0 282458002467 Pfam match to entry PF01854 RNA_pol_A2, RNA polymerase A/beta'/A subunit, score -31.00, E-value 1.1e-07 282458002468 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 282458002469 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 282458002470 Pfam match to entry PF01248 Ribosomal_L7Ae, Ribosomal protein L7Ae/L30e/S12e/Gadd45 family, score 64.20, E-value 2.8e-15 282458002471 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 282458002472 S17 interaction site [polypeptide binding]; other site 282458002473 S8 interaction site; other site 282458002474 16S rRNA interaction site [nucleotide binding]; other site 282458002475 streptomycin interaction site [chemical binding]; other site 282458002476 23S rRNA interaction site [nucleotide binding]; other site 282458002477 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 282458002478 Pfam match to entry PF00164 Ribosomal_S12, Ribosomal protein S12, score 251.30, E-value 1.3e-71 282458002479 PS00055 Ribosomal protein S12 signature. 282458002480 30S ribosomal protein S7; Validated; Region: PRK05302 282458002481 Pfam match to entry PF00177 Ribosomal_S7, Ribosomal protein S7p/S5e, score 326.70, E-value 2.7e-94 282458002482 PS00052 Ribosomal protein S7 signature. 282458002483 elongation factor G; Reviewed; Region: PRK00007 282458002484 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 282458002485 G1 box; other site 282458002486 putative GEF interaction site [polypeptide binding]; other site 282458002487 GTP/Mg2+ binding site [chemical binding]; other site 282458002488 Switch I region; other site 282458002489 G2 box; other site 282458002490 G3 box; other site 282458002491 Switch II region; other site 282458002492 G4 box; other site 282458002493 G5 box; other site 282458002494 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 282458002495 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 282458002496 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 282458002497 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family, score 590.10, E-value 1.4e-173 282458002498 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002499 PS00301 GTP-binding elongation factors signature. 282458002500 Pfam match to entry PF00679 EFG_C, Elongation factor G C-terminus, score 358.30, E-value 8.2e-104 282458002501 elongation factor Tu; Reviewed; Region: PRK00049 282458002502 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 282458002503 G1 box; other site 282458002504 GEF interaction site [polypeptide binding]; other site 282458002505 GTP/Mg2+ binding site [chemical binding]; other site 282458002506 Switch I region; other site 282458002507 G2 box; other site 282458002508 G3 box; other site 282458002509 Switch II region; other site 282458002510 G4 box; other site 282458002511 G5 box; other site 282458002512 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 282458002513 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 282458002514 Antibiotic Binding Site [chemical binding]; other site 282458002515 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family, score 554.90, E-value 5.4e-163 282458002516 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002517 PS00301 GTP-binding elongation factors signature. 282458002518 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 282458002519 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 282458002520 metal binding site [ion binding]; metal-binding site 282458002521 dimer interface [polypeptide binding]; other site 282458002522 Pfam match to entry PF01546 Peptidase_M20, Peptidase M20/M25/M40, score 165.70, E-value 1.3e-46 282458002523 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 282458002524 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 282458002525 substrate-cofactor binding pocket; other site 282458002526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458002527 catalytic residue [active] 282458002528 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class-I, score 142.40, E-value 7.7e-39 282458002529 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 282458002530 chaperone protein HchA; Provisional; Region: PRK04155 282458002531 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 282458002532 conserved cys residue [active] 282458002533 Pfam match to entry PF01965 ThiJ, ThiJ/PfpI family, score 12.10, E-value 0.0029 282458002534 ribulokinase; Provisional; Region: PRK04123 282458002535 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 282458002536 N- and C-terminal domain interface [polypeptide binding]; other site 282458002537 active site 282458002538 MgATP binding site [chemical binding]; other site 282458002539 catalytic site [active] 282458002540 metal binding site [ion binding]; metal-binding site 282458002541 carbohydrate binding site [chemical binding]; other site 282458002542 homodimer interface [polypeptide binding]; other site 282458002543 Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases, N-terminal domain, score -44.50, E-value 1.4e-05 282458002544 Pfam match to entry PF02782 FGGY_C, FGGY family of carbohydrate kinases, C-terminal domain, score 43.30, E-value 4.7e-11 282458002545 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 282458002546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 282458002547 NAD(P) binding site [chemical binding]; other site 282458002548 active site 282458002549 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 282458002550 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 282458002551 homodimer interface [polypeptide binding]; other site 282458002552 substrate-cofactor binding pocket; other site 282458002553 catalytic residue [active] 282458002554 Pfam match to entry PF01063 aminotran_4, Aminotransferase class IV, score 461.50, E-value 7.1e-135 282458002555 PS00770 Aminotransferases class-IV signature. 282458002556 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 282458002557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458002558 motif II; other site 282458002559 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 100.40, E-value 3.6e-26 282458002560 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 282458002561 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 282458002562 Substrate-binding site [chemical binding]; other site 282458002563 Substrate specificity [chemical binding]; other site 282458002564 Pfam match to entry PF01712 dNK, Deoxynucleoside kinase, score 167.30, E-value 2.5e-46 282458002565 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002566 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 282458002567 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 282458002568 Substrate-binding site [chemical binding]; other site 282458002569 Substrate specificity [chemical binding]; other site 282458002570 Pfam match to entry PF01712 dNK, Deoxynucleoside kinase, score 81.40, E-value 1.8e-20 282458002571 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002572 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 282458002573 nucleoside/Zn binding site; other site 282458002574 dimer interface [polypeptide binding]; other site 282458002575 catalytic motif [active] 282458002576 Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region, score 150.80, E-value 2.4e-41 282458002577 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 282458002578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458002579 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 282458002580 active site 282458002581 motif I; other site 282458002582 motif II; other site 282458002583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458002584 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 35.80, E-value 9.9e-07 282458002585 PS01228 Hypothetical cof family signature 1. 282458002586 PS01229 Hypothetical cof family signature 2. 282458002587 Predicted flavoprotein [General function prediction only]; Region: COG0431 282458002588 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 282458002589 Signal peptide predicted for SAR0566 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.966 between residues 50 and 51; signal peptide 282458002590 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282458002591 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 282458002592 Cna protein B-type domain; Region: Cna_B; pfam05738 282458002593 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 282458002594 2 probable transmembrane helices predicted for SAR0566 by TMHMM2.0 at aa 21-43 and 882-899 282458002595 Imperfect repeat, (a/t)(c/g)(a/t/c)ga(a/t/c), x71 282458002596 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 45.00, E-value 1.7e-09 282458002597 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282458002598 Signal peptide predicted for SAR0567 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 52 and 53; signal peptide 282458002599 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282458002600 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 282458002601 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 282458002602 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 282458002603 Cna protein B-type domain; Region: Cna_B; pfam05738 282458002604 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 282458002605 2 probable transmembrane helices predicted for SAR0567 by TMHMM2.0 at aa 23-45 and 1113-1130 282458002606 Imperfect repeat, (a/t)(c/g)(a/t/c)ga(t/c), x74 282458002607 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 45.00, E-value 1.7e-09 282458002608 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282458002609 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 282458002610 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 282458002611 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 282458002612 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 152.90, E-value 5.5e-42 282458002613 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 282458002614 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 282458002615 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 282458002616 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 113.40, E-value 2.5e-30 282458002617 putative GTP cyclohydrolase; Provisional; Region: PRK13674 282458002618 Pfam match to entry PF02649 DUF198, Uncharacterized ACR, COG1469, score 205.70, E-value 7.1e-58 282458002619 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 282458002620 Pfam match to entry PF02585 DUF158, Uncharacterized LmbE-like protein, COG2120, score 12.80, E-value 4.6e-07 282458002621 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 282458002622 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 282458002623 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 282458002624 active site 282458002625 trimer interface [polypeptide binding]; other site 282458002626 allosteric site; other site 282458002627 active site lid [active] 282458002628 hexamer (dimer of trimers) interface [polypeptide binding]; other site 282458002629 Pfam match to entry PF01182 Glucosamine_iso, Glucosamine-6-phosphate isomerases/6-phosphogluconolactonases, score 192.60, E-value 6.4e-54 282458002630 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 282458002631 active site 282458002632 dimer interface [polypeptide binding]; other site 282458002633 magnesium binding site [ion binding]; other site 282458002634 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 282458002635 tetramer interface [polypeptide binding]; other site 282458002636 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 282458002637 active site 282458002638 Pfam match to entry PF01380 SIS, SIS domain, score 53.20, E-value 5.8e-12 282458002639 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 282458002640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458002641 motif II; other site 282458002642 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 98.40, E-value 1.4e-25 282458002643 proline/glycine betaine transporter; Provisional; Region: PRK10642 282458002644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458002645 putative substrate translocation pore; other site 282458002646 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score 153.70, E-value 3.2e-42 282458002647 12 probable transmembrane helices predicted for SAR0577 by TMHMM2.0 at aa 20-42, 62-84, 91-113, 118-140, 160-182, 192-211, 247-269, 279-301, 313-332, 337-356, 377-399 and 409-428 282458002648 PS00217 Sugar transport proteins signature 2. 282458002649 1 probable transmembrane helix predicted for SAR0578 by TMHMM2.0 at aa 28-50 282458002650 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 282458002651 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 282458002652 acyl-activating enzyme (AAE) consensus motif; other site 282458002653 AMP binding site [chemical binding]; other site 282458002654 active site 282458002655 CoA binding site [chemical binding]; other site 282458002656 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 110.60, E-value 3.3e-30 282458002657 PS00455 AMP-binding domain signature. 282458002658 Pfam match to entry PF00108 thiolase, Thiolase, N-terminal domain, score 189.80, E-value 4.2e-53 282458002659 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 282458002660 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 282458002661 dimer interface [polypeptide binding]; other site 282458002662 active site 282458002663 Pfam match to entry PF02803 thiolase_C, Thiolase, C-terminal domain, score 113.60, E-value 3.7e-30 282458002664 PS00737 Thiolases signature 2. 282458002665 hypothetical protein; Provisional; Region: PRK08582 282458002666 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 282458002667 dimer interface [polypeptide binding]; other site 282458002668 substrate binding site [chemical binding]; other site 282458002669 ATP binding site [chemical binding]; other site 282458002670 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002671 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 282458002672 ligand binding site [chemical binding]; other site 282458002673 active site 282458002674 UGI interface [polypeptide binding]; other site 282458002675 catalytic site [active] 282458002676 Pfam match to entry PF00315 UNG, Uracil-DNA glycosylase, score 358.70, E-value 6.4e-104 282458002677 PS00130 Uracil-DNA glycosylase signature. 282458002678 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 282458002679 Signal peptide predicted for SAR0588 by SignalP 2.0 HMM (Signal peptide probabilty 0.970) with cleavage site probability 0.657 between residues 22 and 23; signal peptide 282458002680 4 probable transmembrane helices predicted for SAR0588 by TMHMM2.0 at aa 4-26, 47-64, 68-87 and 94-116 282458002681 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 282458002682 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score -179.50, E-value 5.4e-06 282458002683 12 probable transmembrane helices predicted for SAR0589 by TMHMM2.0 at aa 21-40, 50-72, 93-115, 138-160, 173-195, 210-229, 249-271, 291-313, 346-365, 375-397, 410-429 and 434-456 282458002684 Uncharacterized conserved protein [Function unknown]; Region: COG3610 282458002685 4 probable transmembrane helices predicted for SAR0590 by TMHMM2.0 at aa 2-24, 44-66, 78-100 and 110-132 282458002686 Uncharacterized conserved protein [Function unknown]; Region: COG2966 282458002687 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 282458002688 4 probable transmembrane helices predicted for SAR0591 by TMHMM2.0 at aa 138-160, 170-192, 197-219 and 234-253 282458002689 putative heme peroxidase; Provisional; Region: PRK12276 282458002690 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 282458002691 Pfam match to entry PF01515 PTA_PTB, Phosphate acetyl/butaryl transferase, score 541.60, E-value 5.5e-159 282458002692 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 282458002693 Pfam match to entry PF02539 Lipoate_A, Lipoate-protein ligase A, score 58.70, E-value 1.3e-13 282458002694 mevalonate kinase; Region: mevalon_kin; TIGR00549 282458002695 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 282458002696 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 282458002697 Pfam match to entry PF00288 GHMP_kinases, GHMP kinases ATP-binding protein, score 25.90, E-value 7.7e-06 282458002698 PS00627 GHMP kinases ATP-binding domain. 282458002699 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 282458002700 diphosphomevalonate decarboxylase; Region: PLN02407 282458002701 Pfam match to entry PF00288 GHMP_kinases, GHMP kinases ATP-binding protein, score 17.80, E-value 0.0016 282458002702 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 282458002703 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 282458002704 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 282458002705 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 282458002706 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 282458002707 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 282458002708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282458002709 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 282458002710 Pfam match to entry PF02852 pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 96.20, E-value 6.3e-25 282458002711 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 277.80, E-value 1.4e-79 282458002712 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 282458002713 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002714 Predicted transcriptional regulator [Transcription]; Region: COG1959 282458002715 Transcriptional regulator; Region: Rrf2; pfam02082 282458002716 Predicted helix-turn-helix motif with score 1199 (+3.27 SD) at aa 23-44, sequence FNSSSLAELTCLNPVQLRRVTT 282458002717 LXG domain of WXG superfamily; Region: LXG; pfam04740 282458002718 2 probable transmembrane helices predicted for SAR0602 by TMHMM2.0 at aa 362-384 and 388-410 282458002719 Protein of unknown function (DUF443); Region: DUF443; pfam04276 282458002720 5 probable transmembrane helices predicted for SAR0603 by TMHMM2.0 at aa 23-45, 70-89, 99-118, 147-169 and 174-196 282458002721 Similar to Bacillus halodurans hypothetical protein BH0979 TR:Q9KE77 (EMBL:AP001510) (213 aa) fasta scores: E(): 0.043, 24.651% id in 215 aa. Similar to SAR0603, 59.4 % identity in 197 aa overlap amd SAR0607, 51.3% identity in 193 aa overlap. Contains a frameshift after codon 75; membrane protein (pseudogene) 282458002722 4 probable transmembrane helices predicted for SAR0605 by TMHMM2.0 at aa 24-46, 100-117, 138-160 and 175-197 282458002723 Protein of unknown function (DUF443); Region: DUF443; pfam04276 282458002724 5 probable transmembrane helices predicted for SAR0607 by TMHMM2.0 at aa 23-45, 68-85, 98-117, 146-168 and 175-197 282458002725 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 282458002726 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 282458002727 active site 282458002728 catalytic tetrad [active] 282458002729 Pfam match to entry PF00248 aldo_ket_red, Aldo/keto reductase, score 250.40, E-value 8.4e-74 282458002730 PS00062 Aldo/keto reductase signature 2. 282458002731 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 282458002732 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 282458002733 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 282458002734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458002735 Coenzyme A binding pocket [chemical binding]; other site 282458002736 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 59.70, E-value 6.2e-14 282458002737 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 282458002738 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 282458002739 Zn2+ binding site [ion binding]; other site 282458002740 Mg2+ binding site [ion binding]; other site 282458002741 Pfam match to entry PF01966 HD, HD domain, score 65.20, E-value 1.4e-15 282458002742 YwhD family; Region: YwhD; pfam08741 282458002743 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 282458002744 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 282458002745 NAD binding site [chemical binding]; other site 282458002746 substrate binding site [chemical binding]; other site 282458002747 catalytic Zn binding site [ion binding]; other site 282458002748 tetramer interface [polypeptide binding]; other site 282458002749 structural Zn binding site [ion binding]; other site 282458002750 Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases, score 359.10, E-value 4.7e-104 282458002751 PS00190 Cytochrome c family heme-binding site signature. 282458002752 PS00059 Zinc-containing alcohol dehydrogenases signature. 282458002753 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 282458002754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 282458002755 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 282458002756 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 282458002757 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 282458002758 active site 282458002759 HIGH motif; other site 282458002760 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 282458002761 KMSK motif region; other site 282458002762 tRNA binding surface [nucleotide binding]; other site 282458002763 DALR anticodon binding domain; Region: DALR_1; smart00836 282458002764 anticodon binding site; other site 282458002765 Pfam match to entry PF00750 tRNA-synt_1d, tRNA synthetases class I (R), score 480.80, E-value 1.1e-140 282458002766 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282458002767 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 282458002768 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 282458002769 minor groove reading motif; other site 282458002770 helix-hairpin-helix signature motif; other site 282458002771 substrate binding pocket [chemical binding]; other site 282458002772 active site 282458002773 Pfam match to entry PF00730 HhH-GPD, HhH-GPD superfamily base excision DNA repair protein, score 43.10, E-value 6.2e-09 282458002774 Signal peptide predicted for SAR0618 by SignalP 2.0 HMM (Signal peptide probabilty 0.799) with cleavage site probability 0.361 between residues 26 and 27; signal peptide 282458002775 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 282458002776 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 282458002777 putative binding site residues; other site 282458002778 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458002779 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 110.90, E-value 2.5e-29 282458002780 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282458002781 ABC-ATPase subunit interface; other site 282458002782 dimer interface [polypeptide binding]; other site 282458002783 putative PBP binding regions; other site 282458002784 10 probable transmembrane helices predicted for SAR0619 by TMHMM2.0 at aa 7-26, 46-68, 75-97, 101-123, 130-152, 175-197, 210-229, 233-250, 263-285 and 290-309 282458002785 Pfam match to entry PF01032 FecCD_family, FecCD transport family, score 153.10, E-value 4.7e-42 282458002786 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 282458002787 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458002788 motif II; other site 282458002789 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 82.00, E-value 1.2e-20 282458002790 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002791 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 282458002792 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 282458002793 Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold, score 42.60, E-value 8.8e-09 282458002794 Signal peptide predicted for SAR0622 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.892 between residues 27 and 28; signal peptide 282458002795 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002796 5 probable transmembrane helices predicted for SAR0623 by TMHMM2.0 at aa 66-88, 98-120, 132-154, 164-183 and 213-230 282458002797 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 282458002798 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 282458002799 Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold, score 106.00, E-value 7.5e-28 282458002800 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282458002801 Transcriptional regulators [Transcription]; Region: MarR; COG1846 282458002802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 282458002803 Protein of unknown function, DUF606; Region: DUF606; pfam04657 282458002804 10 probable transmembrane helices predicted for SAR0626 by TMHMM2.0 at aa 4-26, 33-54, 69-91, 98-120, 130-148, 160-182, 192-214, 233-255, 259-281 and 294-308 282458002805 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 282458002806 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 282458002807 active site 282458002808 DNA binding site [nucleotide binding] 282458002809 Int/Topo IB signature motif; other site 282458002810 Pfam match to entry PF00589 Phage_integrase, Phage integrase, score 39.60, E-value 3.3e-08 282458002811 Signal peptide predicted for SAR0630 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.404 between residues 27 and 28; signal peptide 282458002812 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 282458002813 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 282458002814 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 282458002815 21 probable transmembrane helices predicted for SAR0630 by TMHMM2.0 at aa 4-21, 30-52, 77-99, 112-129, 133-155, 167-189, 209-231, 244-266, 271-293, 300-320, 330-352, 385-407, 427-449, 473-495, 525-547, 591-613, 628-647, 654-671, 676-698, 711-733 and 770-789 282458002816 Pfam match to entry PF00662 oxidored_q1_N, NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus, score 35.10, E-value 1.1e-07 282458002817 Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 194.60, E-value 1.6e-54 282458002818 Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 72.70, E-value 1.6e-19 282458002819 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 282458002820 4 probable transmembrane helices predicted for SAR0631 by TMHMM2.0 at aa 7-29, 34-56, 68-90 and 114-136 282458002821 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 282458002822 Pfam match to entry PF01898 DUF67, Protein of unknown function DUF67, score 100.10, E-value 4.3e-26 282458002823 3 probable transmembrane helices predicted for SAR0632 by TMHMM2.0 at aa 4-26, 28-50 and 70-92 282458002824 Signal peptide predicted for SAR0633 by SignalP 2.0 HMM (Signal peptide probabilty 0.945) with cleavage site probability 0.581 between residues 23 and 24; signal peptide 282458002825 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 282458002826 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 282458002827 14 probable transmembrane helices predicted for SAR0633 by TMHMM2.0 at aa 5-23, 30-52, 77-99, 108-127, 131-153, 160-182, 206-228, 235-257, 270-292, 299-321, 326-348, 368-390, 405-427 and 451-470 282458002828 Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 176.90, E-value 3.4e-49 282458002829 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 282458002830 3 probable transmembrane helices predicted for SAR0634 by TMHMM2.0 at aa 25-47, 60-82 and 102-120 282458002831 Pfam match to entry PF01899 DUF68, Protein of unknown function DUF68, score -2.50, E-value 0.00013 282458002832 Signal peptide predicted for SAR0635 by SignalP 2.0 HMM (Signal peptide probabilty 0.792) with cleavage site probability 0.468 between residues 35 and 36; signal peptide 282458002833 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 282458002834 3 probable transmembrane helices predicted for SAR0635 by TMHMM2.0 at aa 4-26, 38-60 and 70-92 282458002835 Similar to Oceanobacillus iheyensis Na(+):H(+) antiporter OB3103 SWALL:Q8ELW1 (EMBL:AP004603) (154 aa) fasta scores: E(): 2e-17, 42.44% id in 139 aa, and to Staphylococcus aureus hypothetical protein SAV0628 or SA0584 SWALL:Q99VY6 (EMBL:AP003360) (145 aa) fasta scores: E(): 3e-50, 97.24% id in 145 aa. CDS contains a nonsense mutation (ochre) after codon 120; membrane protein (pseudogene) 282458002836 Signal peptide predicted for SAR0636 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.512 between residues 27 and 28 282458002837 3 probable transmembrane helices predicted for SAR0636 by TMHMM2.0 at aa 7-29, 49-71 and 73-95 282458002838 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 282458002839 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 282458002840 Pfam match to entry PF00999 Na_H_Exchanger, Sodium/hydrogen exchanger family, score 213.30, E-value 3.6e-60 282458002841 13 probable transmembrane helices predicted for SAR0637 by TMHMM2.0 at aa 7-24, 29-51, 84-106, 111-133, 153-175, 180-202, 215-234, 238-255, 276-298, 308-325, 327-349, 369-391 and 404-426 282458002842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458002843 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 282458002844 putative substrate translocation pore; other site 282458002845 11 probable transmembrane helices predicted for SAR0638 by TMHMM2.0 at aa 7-29, 39-61, 73-92, 102-124, 131-153, 163-182, 202-224, 234-253, 273-295, 326-348 and 355-377 282458002846 Similar to the C-terminal regions of Erwinia chrysanthemi indigoidine synthesis protein IdgB TR:Q9KHB5 (EMBL:AF265211) (230 aa) fasta scores: E(): 5.2e-06, 27.322% id in 183 aa, and Bacillus subtilis HPr(Ser-P) phosphatase PtsL TR:Q9JMQ2 (EMBL:AF017113) (216 aa) fasta scores: E(): 3e-05, 23.256% id in 172 aa. CDS appears to be truncated at the N-terminus, possible gene remnant. Contains a frameshift after codon 99; haloacid dehydrogenase-like hydrolase (pseudogene) 282458002847 Signal peptide predicted for SAR0641 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.322 between residues 24 and 25; signal peptide 282458002848 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 282458002849 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 282458002850 metal binding site [ion binding]; metal-binding site 282458002851 Pfam match to entry PF01297 Lipoprotein_4, Periplasmic solute binding protein family, score 479.50, E-value 2.6e-140 282458002852 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002853 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458002854 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 282458002855 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282458002856 ABC-ATPase subunit interface; other site 282458002857 dimer interface [polypeptide binding]; other site 282458002858 putative PBP binding regions; other site 282458002859 Pfam match to entry PF00950 ABC-3, ABC 3 transport family, score 362.10, E-value 5.9e-105 282458002860 8 probable transmembrane helices predicted for SAR0642 by TMHMM2.0 at aa 13-35, 50-81, 93-115, 130-152, 165-187, 192-214, 221-243 and 248-265 282458002861 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 282458002862 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 282458002863 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 161.30, E-value 1.6e-44 282458002864 PS00211 ABC transporters family signature. 282458002865 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002866 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 282458002867 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 282458002868 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 282458002869 FeoA domain; Region: FeoA; pfam04023 282458002870 Pfam match to entry PF01325 Fe_dep_repress, Iron dependent repressor, N-terminal DNA binding domain, score 110.60, E-value 3e-29 282458002871 Pfam match to entry PF02742 Fe_dep_repr_C, Iron dependent repressor, metal binding and dimerisation domain, score 115.70, E-value 8.8e-31 282458002872 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 282458002873 6 probable transmembrane helices predicted for SAR0645 by TMHMM2.0 at aa 7-29, 96-118, 125-144, 148-165, 170-192 and 221-243 282458002874 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282458002875 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 282458002876 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 282458002877 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 282458002878 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 282458002879 Walker A/P-loop; other site 282458002880 ATP binding site [chemical binding]; other site 282458002881 Q-loop/lid; other site 282458002882 ABC transporter signature motif; other site 282458002883 Walker B; other site 282458002884 D-loop; other site 282458002885 H-loop/switch region; other site 282458002886 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 106.90, E-value 3.9e-28 282458002887 PS00211 ABC transporters family signature. 282458002888 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002889 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 282458002890 ABC-2 type transporter; Region: ABC2_membrane; cl17235 282458002891 Pfam match to entry PF01061 ABC2_membrane, ABC-2 type transporter, score 143.20, E-value 4.7e-39 282458002892 5 probable transmembrane helices predicted for SAR0648 by TMHMM2.0 at aa 40-62, 77-96, 132-154, 158-180 and 247-266 282458002893 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 282458002894 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 282458002895 active site 282458002896 Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferase, score 36.70, E-value 5.3e-07 282458002897 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 282458002898 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 282458002899 active site 282458002900 nucleotide binding site [chemical binding]; other site 282458002901 HIGH motif; other site 282458002902 KMSKS motif; other site 282458002903 Pfam match to entry PF01467 Cytidylyltransf, Cytidylyltransferase, score 172.50, E-value 7.1e-48 282458002904 Signal peptide predicted for SAR0652 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.630 between residues 24 and 25; signal peptide 282458002905 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 282458002906 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 282458002907 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 282458002908 1 probable transmembrane helix predicted for SAR0652 by TMHMM2.0 at aa 401-423 282458002909 Pfam match to entry PF00768 Peptidase_S11, D-alanyl-D-alanine carboxypeptidase, score 279.90, E-value 3.3e-80 282458002910 Signal peptide predicted for SAR0653 by SignalP 2.0 HMM (Signal peptide probabilty 0.937) with cleavage site probability 0.397 between residues 44 and 45; signal peptide 282458002911 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 282458002912 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 282458002913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282458002914 Walker A/P-loop; other site 282458002915 ATP binding site [chemical binding]; other site 282458002916 Q-loop/lid; other site 282458002917 ABC transporter signature motif; other site 282458002918 Walker B; other site 282458002919 D-loop; other site 282458002920 H-loop/switch region; other site 282458002921 6 probable transmembrane helices predicted for SAR0653 by TMHMM2.0 at aa 21-43, 58-80, 134-153, 158-180, 238-260 and 270-292 282458002922 Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region., score 150.20, E-value 3.6e-41 282458002923 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 204.70, E-value 1.4e-57 282458002924 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002925 PS00211 ABC transporters family signature. 282458002926 similar to hypothetical protein 282458002927 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 282458002928 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 282458002929 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 282458002930 Pfam match to entry PF01773 Nucleoside_tra2, Na+ dependent nucleoside transporter, score 339.80, E-value 3e-98 282458002931 10 probable transmembrane helices predicted for SAR0655 by TMHMM2.0 at aa 2-21, 27-49, 62-81, 91-113, 165-187, 192-214, 243-265, 294-316, 348-370 and 385-407 282458002932 Uncharacterized conserved protein [Function unknown]; Region: COG1284 282458002933 Signal peptide predicted for SAR0656 by SignalP 2.0 HMM (Signal peptide probabilty 0.965) with cleavage site probability 0.569 between residues 24 and 25; signal peptide 282458002934 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 282458002935 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 282458002936 Pfam match to entry PF02588 DUF161, Uncharacterized BCR, YitT family COG1284, score 150.00, E-value 4.2e-41 282458002937 5 probable transmembrane helices predicted for SAR0656 by TMHMM2.0 at aa 9-31, 41-63, 75-97, 112-134 and 147-166 282458002938 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 282458002939 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 282458002940 Walker A/P-loop; other site 282458002941 ATP binding site [chemical binding]; other site 282458002942 Q-loop/lid; other site 282458002943 ABC transporter signature motif; other site 282458002944 Walker B; other site 282458002945 D-loop; other site 282458002946 H-loop/switch region; other site 282458002947 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 216.30, E-value 4.6e-61 282458002948 PS00017 ATP/GTP-binding site motif A (P-loop). 282458002949 PS00211 ABC transporters family signature. 282458002950 Signal peptide predicted for SAR0658 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.931 between residues 40 and 41; signal peptide 282458002951 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 282458002952 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282458002953 ABC-ATPase subunit interface; other site 282458002954 dimer interface [polypeptide binding]; other site 282458002955 putative PBP binding regions; other site 282458002956 9 probable transmembrane helices predicted for SAR0658 by TMHMM2.0 at aa 12-34, 63-85, 98-117, 121-143, 155-177, 201-223, 244-266, 276-298 and 305-327 282458002957 Pfam match to entry PF01032 FecCD_family, FecCD transport family, score 383.40, E-value 2.3e-111 282458002958 Signal peptide predicted for SAR0659 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.246 between residues 28 and 29; signal peptide 282458002959 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 282458002960 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282458002961 ABC-ATPase subunit interface; other site 282458002962 dimer interface [polypeptide binding]; other site 282458002963 putative PBP binding regions; other site 282458002964 9 probable transmembrane helices predicted for SAR0659 by TMHMM2.0 at aa 12-31, 65-82, 95-112, 122-144, 151-173, 198-217, 247-269, 284-301 and 308-330 282458002965 Pfam match to entry PF01032 FecCD_family, FecCD transport family, score 356.10, E-value 3.8e-103 282458002966 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 282458002967 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 282458002968 Pfam match to entry PF02733 Dak1, Dak1 domain, score 348.00, E-value 1.1e-100 282458002969 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 282458002970 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 282458002971 Pfam match to entry PF02734 Dak2, DAK2 domain, score 74.80, E-value 1.8e-18 282458002972 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 282458002973 Uncharacterized membrane protein [Function unknown]; Region: COG3949 282458002974 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 282458002975 Na binding site [ion binding]; other site 282458002976 10 probable transmembrane helices predicted for SAR0664 by TMHMM2.0 at aa 7-26, 36-55, 85-107, 117-134, 141-163, 186-208, 215-237, 264-286, 299-321 and 325-344 282458002977 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 282458002978 Signal peptide predicted for SAR0665 by SignalP 2.0 HMM (Signal peptide probabilty 0.652) with cleavage site probability 0.319 between residues 23 and 24; signal peptide 282458002979 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 282458002980 substrate binding pocket [chemical binding]; other site 282458002981 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 282458002982 1 probable transmembrane helix predicted for SAR0665 by TMHMM2.0 at aa 7-26 282458002983 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 282458002984 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458002985 Coenzyme A binding pocket [chemical binding]; other site 282458002986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 282458002987 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 64.40, E-value 2.5e-15 282458002988 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 282458002989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 282458002990 NAD(P) binding site [chemical binding]; other site 282458002991 active site 282458002992 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282458002993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458002994 active site 282458002995 phosphorylation site [posttranslational modification] 282458002996 intermolecular recognition site; other site 282458002997 dimerization interface [polypeptide binding]; other site 282458002998 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282458002999 DNA binding site [nucleotide binding] 282458003000 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 78.30, E-value 1.6e-19 282458003001 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 50.40, E-value 1e-13 282458003002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 282458003003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 282458003004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458003005 ATP binding site [chemical binding]; other site 282458003006 Mg2+ binding site [ion binding]; other site 282458003007 G-X-G motif; other site 282458003008 2 probable transmembrane helices predicted for SAR0670 by TMHMM2.0 at aa 17-34 and 44-63 282458003009 Pfam match to entry PF00512 signal, His Kinase A (phosphoacceptor) domain, score 21.00, E-value 0.0071 282458003010 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 100.00, E-value 2.7e-26 282458003011 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 282458003012 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282458003013 Walker A/P-loop; other site 282458003014 ATP binding site [chemical binding]; other site 282458003015 Q-loop/lid; other site 282458003016 ABC transporter signature motif; other site 282458003017 Walker B; other site 282458003018 D-loop; other site 282458003019 H-loop/switch region; other site 282458003020 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 204.50, E-value 1.6e-57 282458003021 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003022 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 282458003023 FtsX-like permease family; Region: FtsX; pfam02687 282458003024 11 probable transmembrane helices predicted for SAR0672 by TMHMM2.0 at aa 15-37, 58-80, 90-112, 117-139, 154-176, 197-219, 229-251, 286-308, 509-531, 565-587 and 597-619 282458003025 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 282458003026 Pfam match to entry PF01865 DUF47, Protein of unknown function DUF47, score 18.00, E-value 3.4e-07 282458003027 Signal peptide predicted for SAR0674 by SignalP 2.0 HMM (Signal peptide probabilty 0.965) with cleavage site probability 0.858 between residues 30 and 31; signal peptide 282458003028 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 282458003029 7 probable transmembrane helices predicted for SAR0674 by TMHMM2.0 at aa 2-24, 46-68, 81-103, 108-130, 137-159, 221-243 and 309-331 282458003030 Pfam match to entry PF01384 PHO4, Phosphate transporter family, score 197.40, E-value 1.7e-62 282458003031 Pfam match to entry PF01384 PHO4, Phosphate transporter family, score 151.40, E-value 8.4e-48 282458003032 Signal peptide predicted for SAR0675 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 25 and 26; signal peptide 282458003033 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282458003034 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 282458003035 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282458003036 Surface antigen [General function prediction only]; Region: COG3942 282458003037 CHAP domain; Region: CHAP; pfam05257 282458003038 Pfam match to entry PF01476 LysM, LysM domain, score 66.60, E-value 5.3e-16 282458003039 Pfam match to entry PF01476 LysM, LysM domain, score 65.80, E-value 9.1e-16 282458003040 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 282458003041 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 282458003042 6 probable transmembrane helices predicted for SAR0676 by TMHMM2.0 at aa 21-43, 47-64, 71-93, 103-125, 130-152 and 156-175 282458003043 Poor database matches. Contains a frameshift after codon 50. Frameshift occurs at a AT repeat (x6). Similar to Staphylococcus aureus subsp. aureus strain N315 AraC/XylS family transcriptional regulator SA0622 TR:Q99VV4 (EMBL:AP003131) (716 aa) fasta scores: E(): 0, 96.374% id in 717 aa.;AraC family regulatory protein (pseudogene) 282458003044 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 85.70, E-value 9.4e-22 282458003045 Predicted helix-turn-helix motif with score 1764 (+5.19 SD) at aa 102-123, sequence LTLKSVADKLFVSKSNLSSQFH 282458003046 PS00041 Bacterial regulatory proteins, araC family signature. 282458003047 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282458003048 hypothetical protein; Provisional; Region: PRK12378 282458003049 Pfam match to entry PF01709 DUF28, Domain of unknown function DUF28, score 387.10, E-value 1.8e-112 282458003050 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 282458003051 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 282458003052 Transcriptional regulator [Transcription]; Region: LysR; COG0583 282458003053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 282458003054 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 282458003055 dimerization interface [polypeptide binding]; other site 282458003056 Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 114.90, E-value 1.6e-30 282458003057 Predicted helix-turn-helix motif with score 1745 (+5.13 SD) at aa 16-37, sequence KTLRKAAEILYISQPAVTQRLK 282458003058 PS00044 Bacterial regulatory proteins, lysR family signature. 282458003059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458003060 sugar efflux transporter; Region: 2A0120; TIGR00899 282458003061 putative substrate translocation pore; other site 282458003062 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -114.50, E-value 0.01 282458003063 12 probable transmembrane helices predicted for SAR0684 by TMHMM2.0 at aa 13-35, 45-67, 80-99, 103-125, 145-167, 171-193, 220-242, 257-279, 286-305, 311-333, 340-359 and 369-391 282458003064 Similar to Oceanobacillus iheyensis hypothetical conserved protein OB0564 SWALL:Q8ESQ7 (EMBL:AP004594) (161 aa) fasta scores: E(): 2.5e-27, 48.73% id in 158 aa, and to Staphylococcus aureus hypothetical protein SAV0674 or SA0629 or MW0636 SWALL:Q99VU7 (EMBL:AP003360) (162 aa) fasta scores: E(): 6.3e-56, 95.06% id in 162 aa. CDS is distrupted by the insertion of transposase, SAR0696, and subsequent insertion of IS element and integration of a plasmid; membrane protein (pseudogene) 282458003065 5 probable transmembrane helices predicted for SAR0685 by TMHMM2.0 at aa 2-21, 25-42, 47-69, 89-111 and 132-154 282458003066 Insertion sequence IS1272 282458003067 Almost identical to Staphylococcus aureus prophage phiPV83 transposase SWALL:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 4.9e-202, 99.81% id in 548 aa. CDS has been disrupted by the integration of a IS element after codon 403; transposase (pseudogene) 282458003068 Insertion sequence IS431 282458003069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 282458003070 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 282458003071 Integrase core domain; Region: rve; pfam00665 282458003072 Pfam match to entry PF00665 rve, Integrase core domain, score 69.70, E-value 5.7e-19 282458003073 Integrated plasmid 282458003074 2 probable transmembrane helices predicted for SAR0688 by TMHMM2.0 at aa 9-31 and 36-58 282458003075 Similar to the C-terminal regions of Staphylococcus aureus plasmid pI9789 recombinase Sin TR:Q53757 (EMBL:L23109) (202 aa) fasta scores: E(): 2.7e-35, 87.387% id in 111 aa, and to Staphylococcus haemolyticus plasmid pNVH96 recombinase Sin TR:Q9F2H8 (EMBL:AJ302698) (202 aa) fasta scores: E(): 1.3e-33, 86.111% id in 108 aa. Probable gene remnant resulting from plasmid integration;recombinase (fragment) 282458003076 Pfam match to entry PF00239 resolvase, Resolvase class of site-specific recombinases, score 72.70, E-value 9.6e-21 282458003077 Pfam match to entry PF02796 HTH_7, Helix-turn-helix domain of resolvase, score 68.10, E-value 1.9e-16 282458003078 Predicted helix-turn-helix motif with score 2126 (+6.43 SD) at aa 88-109, sequence KSISTIAKEVGITRQTIYRIKN 282458003079 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 282458003080 dimerization interface [polypeptide binding]; other site 282458003081 putative DNA binding site [nucleotide binding]; other site 282458003082 putative Zn2+ binding site [ion binding]; other site 282458003083 Pfam match to entry PF01022 HTH_5, Bacterial regulatory protein, arsR family, score 113.20, E-value 5.1e-30 282458003084 Predicted helix-turn-helix motif with score 991 (+2.56 SD) at aa 30-51, sequence LCACDLLEHFQFSQPTLSHHMK 282458003085 PS00846 Bacterial regulatory proteins, arsR family signature. 282458003086 arsenical pump membrane protein; Provisional; Region: PRK15445 282458003087 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 282458003088 transmembrane helices; other site 282458003089 11 probable transmembrane helices predicted for SAR0691 by TMHMM2.0 at aa 2-19, 23-45, 52-71, 97-119, 140-162, 177-199, 224-241, 245-264, 284-306, 316-335 and 406-428 282458003090 Pfam match to entry PF02040 ArsB, Arsenical pump membrane protein, score 1096.70, E-value 0 282458003091 Low molecular weight phosphatase family; Region: LMWPc; cd00115 282458003092 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 282458003093 active site 282458003094 Pfam match to entry PF01451 LMWPc, Low molecular weight phosphotyrosine protein phosphatase, score 188.80, E-value 8.4e-53 282458003095 1 probable transmembrane helix predicted for SAR0693 by TMHMM2.0 at aa 31-48 282458003096 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 282458003097 Signal peptide predicted for SAR0694 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.966 between residues 28 and 29; signal peptide 282458003098 1 probable transmembrane helix predicted for SAR0694 by TMHMM2.0 at aa 5-24 282458003099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 282458003100 Signal peptide predicted for SAR0695 by SignalP 2.0 HMM (Signal peptide probabilty 0.972) with cleavage site probability 0.434 between residues 26 and 27; signal peptide 282458003101 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 282458003102 8 probable transmembrane helices predicted for SAR0695 by TMHMM2.0 at aa 7-25, 158-175, 204-226, 241-263, 276-298, 538-557, 578-600 and 610-632 282458003103 Signal peptide predicted for SAR0696 by SignalP 2.0 HMM (Signal peptide probabilty 0.953) with cleavage site probability 0.581 between residues 24 and 25; signal peptide 282458003104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 282458003105 1 probable transmembrane helix predicted for SAR0696 by TMHMM2.0 at aa 5-22 282458003106 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282458003107 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 282458003108 Walker A/P-loop; other site 282458003109 ATP binding site [chemical binding]; other site 282458003110 Q-loop/lid; other site 282458003111 ABC transporter signature motif; other site 282458003112 Walker B; other site 282458003113 D-loop; other site 282458003114 H-loop/switch region; other site 282458003115 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 191.50, E-value 1.3e-53 282458003116 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003117 PS00211 ABC transporters family signature. 282458003118 Insertion sequence IS1272 282458003119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 282458003120 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458003121 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 282458003122 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458003123 Similar to Staphylococcus aureus plasmid pT181 plasmid recombination protein, Pre W:PRE3_STAAU (P03864) (413 aa) fasta scores: E(): 2e-62, 54.265% id in 422 aa, and to Staphylococcus aureus plasmid pSBK203 plasmid recombination protein Pre TR:Q53618 (EMBL:U35036) (422 aa) fasta scores: E(): 1.3e-84, 62.559% id in 422 aa. CDS contain a frameshift after codon 98 and several nonsense mutations (opal, ochre and opal mutations after codons 214, 220 and 401 respectively);plasmid recombination enzyme (pseudogene) 282458003124 Pfam match to entry PF01076 Mob_Pre, Plasmid recombination enzyme, score -10.60, E-value 0.00028 282458003125 Pfam match to entry PF01076 Mob_Pre, Plasmid recombination enzyme, score 3.60, E-value 3.5e-05 282458003126 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 282458003127 Initiator Replication protein; Region: Rep_3; pfam01051 282458003128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282458003129 non-specific DNA binding site [nucleotide binding]; other site 282458003130 salt bridge; other site 282458003131 sequence-specific DNA binding site [nucleotide binding]; other site 282458003132 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 65.50, E-value 1.1e-15 282458003133 Predicted helix-turn-helix motif with score 2329 (+7.12 SD) at aa 16-37, sequence WSQEELANILKVSRQSVSKWES 282458003134 1 probable transmembrane helix predicted for SAR0704 by TMHMM2.0 at aa 86-108 282458003135 1 probable transmembrane helix predicted for SAR0706 by TMHMM2.0 at aa 7-29 282458003136 Similar to Staphylococcus aureus plasmid pSK1 replication-associated protein Orf245 TR:Q9L8I7 (EMBL:AF203376) (245 aa) fasta scores: E(): 4.7e-18, 44.828% id in 261 aa, and to Staphylococcus haemolyticus plasmid pNVH97A hypothetical protein TR:Q9K4M8 (EMBL:AJ400722) (245 aa) fasta scores: E(): 2.8e-41, 64.372% id in 247 aa. Contains a frameshift after codon 72; replication-associated protein (pseudogene) 282458003137 Predicted helix-turn-helix motif with score 1617 (+4.69 SD) at aa 2-23, sequence KSVKKLSEELGVSKQTIFNNIK 282458003138 Similar to Staphylococcus aureus plasmid pSK41 replication initiation protein Rep TR:O87367 (EMBL:AF051917) (319 aa) fasta scores: E(): 3.8e-54, 57.055% id in 326 aa, and to Staphylococcus aureus plasmid pSR1 replication intiation protein Rep TR:Q9FDP3 (EMBL:AF167161) (327 aa) fasta scores: E(): 4.3e-59, 96.308% id in 325 aa. Contains a nonsense mutation (ochre) after codon 1 and a frameshift after codon 156; replication initiation protein (pseudogene) 282458003139 Similar to the C-terminal regions of Staphylococcus aureus replication protein Rep TR:Q53631 (EMBL:U50077) (334 aa) fasta scores: E(): 1.2e-13, 97.778% id in 45 aa, and Staphylococcus epidermidis replication protein Orf334 TR:Q53999 (EMBL:U15783) (334 aa) fasta scores: E(): 1.2e-13, 97.778% id in 45 aa. Probable gene remnant; replication protein (fragment) 282458003140 Pfam match to entry PF01446 Rep, Replication protein, score 68.40, E-value 2e-18 282458003141 Signal peptide predicted for SAR0714 by SignalP 2.0 HMM (Signal peptide probabilty 0.908) with cleavage site probability 0.231 between residues 45 and 46; signal peptide 282458003142 2 probable transmembrane helices predicted for SAR0714 by TMHMM2.0 at aa 16-38 and 42-61 282458003143 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 282458003144 active site 282458003145 1 probable transmembrane helix predicted for SAR0716 by TMHMM2.0 at aa 4-26 282458003146 Transcriptional regulator [Transcription]; Region: LysR; COG0583 282458003147 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 282458003148 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 282458003149 dimerization interface [polypeptide binding]; other site 282458003150 Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 101.60, E-value 1.5e-26 282458003151 PS00044 Bacterial regulatory proteins, lysR family signature. 282458003152 Predicted helix-turn-helix motif with score 1500 (+4.30 SD) at aa 14-35, sequence QSFTKAAENLYTSQPSISRDIK 282458003153 Predicted membrane protein [Function unknown]; Region: COG2855 282458003154 Signal peptide predicted for SAR0718 by SignalP 2.0 HMM (Signal peptide probabilty 0.969) with cleavage site probability 0.669 between residues 37 and 38; signal peptide 282458003155 11 probable transmembrane helices predicted for SAR0718 by TMHMM2.0 at aa 7-26, 31-48, 69-88, 93-115, 122-144, 154-176, 183-200, 215-234, 247-265, 275-297 and 304-326 282458003156 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 282458003157 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 282458003158 catalytic residues [active] 282458003159 catalytic nucleophile [active] 282458003160 Presynaptic Site I dimer interface [polypeptide binding]; other site 282458003161 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 282458003162 Synaptic Flat tetramer interface [polypeptide binding]; other site 282458003163 Synaptic Site I dimer interface [polypeptide binding]; other site 282458003164 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 282458003165 DNA-binding interface [nucleotide binding]; DNA binding site 282458003166 Pfam match to entry PF02796 HTH_7, Helix-turn-helix domain of resolvase, score 70.90, E-value 2.7e-17 282458003167 Predicted helix-turn-helix motif with score 1887 (+5.61 SD) at aa 161-182, sequence TPIKTIAEQWQVSRTTIYRYLN 282458003168 Pfam match to entry PF00239 resolvase, Resolvase class of site-specific recombinases, score 284.50, E-value 2.7e-84 282458003169 PS00398 Site-specific recombinases signature 2. 282458003170 PS00397 Site-specific recombinases active site. 282458003171 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 282458003172 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 282458003173 Soluble P-type ATPase [General function prediction only]; Region: COG4087 282458003174 8 probable transmembrane helices predicted for SAR0720 by TMHMM2.0 at aa 39-58, 62-84, 105-127, 137-159, 289-311, 321-343, 630-652 and 656-678 282458003175 Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 ATPase, score 290.10, E-value 5.1e-87 282458003176 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 107.40, E-value 2.8e-28 282458003177 PS00154 E1-E2 ATPases phosphorylation site. 282458003178 Signal peptide predicted for SAR0721 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.985 between residues 25 and 26; signal peptide 282458003179 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 282458003180 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 282458003181 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 282458003182 Pfam match to entry PF00394 Cu-oxidase, Multicopper oxidase, score 19.60, E-value 0.0015 282458003183 PS00079 Multicopper oxidases signature 1. 282458003184 PS00080 Multicopper oxidases signature 2. 282458003185 Insertion sequence IS1272 282458003186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 282458003187 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458003188 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 282458003189 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458003190 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 282458003191 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 282458003192 metal-binding site [ion binding] 282458003193 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 282458003194 Soluble P-type ATPase [General function prediction only]; Region: COG4087 282458003195 6 probable transmembrane helices predicted for SAR0723 by TMHMM2.0 at aa 106-123, 133-155, 328-350, 365-387, 671-693 and 698-720 282458003196 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 124.40, E-value 2.1e-33 282458003197 PS00154 E1-E2 ATPases phosphorylation site. 282458003198 Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 ATPase, score 348.40, E-value 1e-104 282458003199 Pfam match to entry PF00403 HMA, Heavy-metal-associated domain, score 57.10, E-value 4e-13 282458003200 PS01047 Heavy-metal-associated domain. 282458003201 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 282458003202 dimerization interface [polypeptide binding]; other site 282458003203 putative DNA binding site [nucleotide binding]; other site 282458003204 putative Zn2+ binding site [ion binding]; other site 282458003205 Pfam match to entry PF01022 HTH_5, Bacterial regulatory protein, arsR family, score 112.10, E-value 1e-29 282458003206 PS00846 Bacterial regulatory proteins, arsR family signature. 282458003207 Transposase Tn554 (fragment) 282458003208 Predicted helix-turn-helix motif with score 1150 (+3.10 SD) at aa 40-61, sequence INFNSIAKEANVSKSWLYKEHD 282458003209 Insertion sequence IS431 282458003210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 282458003211 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 282458003212 Integrase core domain; Region: rve; pfam00665 282458003213 Pfam match to entry PF00665 rve, Integrase core domain, score 69.70, E-value 5.7e-19 282458003214 Insertion sequence IS1272 282458003215 Serine incorporator (Serinc); Region: Serinc; pfam03348 282458003216 4 probable transmembrane helices predicted for SAR0728 by TMHMM2.0 at aa 95-117, 127-149, 162-184 and 194-216 282458003217 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 282458003218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458003219 Coenzyme A binding pocket [chemical binding]; other site 282458003220 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 59.60, E-value 6.8e-14 282458003221 Signal peptide predicted for SAR0730 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.551 between residues 25 and 26; signal peptide 282458003222 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458003223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 282458003224 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 282458003225 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 50.00, E-value 5.4e-11 282458003226 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 282458003227 hypothetical protein; Validated; Region: PRK00124 282458003228 Pfam match to entry PF02639 DUF188, Uncharacterized BCR, YaiI/YqxD family COG1671, score 80.40, E-value 3.6e-20 282458003229 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 282458003230 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 282458003231 8 probable transmembrane helices predicted for SAR0736 by TMHMM2.0 at aa 9-31, 46-68, 99-118, 128-145, 162-181, 201-223, 236-258 and 268-287 282458003232 Pfam match to entry PF02673 BacA, Bacitracin resistance protein BacA, score 173.50, E-value 3.5e-48 282458003233 Signal peptide predicted for SAR0737 by SignalP 2.0 HMM (Signal peptide probabilty 0.955) with cleavage site probability 0.591 between residues 37 and 38; signal peptide 282458003234 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 282458003235 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 282458003236 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 282458003237 Walker A/P-loop; other site 282458003238 ATP binding site [chemical binding]; other site 282458003239 Q-loop/lid; other site 282458003240 ABC transporter signature motif; other site 282458003241 Walker B; other site 282458003242 D-loop; other site 282458003243 H-loop/switch region; other site 282458003244 Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region., score 34.10, E-value 3.3e-06 282458003245 5 probable transmembrane helices predicted for SAR0737 by TMHMM2.0 at aa 13-35, 50-72, 125-142, 147-166 and 227-249 282458003246 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 164.20, E-value 2.1e-45 282458003247 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003248 PS00211 ABC transporters family signature. 282458003249 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 282458003250 Signal peptide predicted for SAR0738 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.906 between residues 44 and 45; signal peptide 282458003251 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 282458003252 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 282458003253 Walker A/P-loop; other site 282458003254 ATP binding site [chemical binding]; other site 282458003255 Q-loop/lid; other site 282458003256 ABC transporter signature motif; other site 282458003257 Walker B; other site 282458003258 D-loop; other site 282458003259 H-loop/switch region; other site 282458003260 Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region., score 4.80, E-value 0.0031 282458003261 5 probable transmembrane helices predicted for SAR0738 by TMHMM2.0 at aa 13-35, 45-67, 123-145, 149-171 and 240-262 282458003262 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 146.20, E-value 5.6e-40 282458003263 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003264 PS00211 ABC transporters family signature. 282458003265 Transcriptional regulators [Transcription]; Region: MarR; COG1846 282458003266 MarR family; Region: MarR; pfam01047 282458003267 Pfam match to entry PF01047 MarR, MarR family, score 78.60, E-value 1.3e-19 282458003268 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 282458003269 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 282458003270 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 282458003271 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003272 Pfam match to entry PF02492 cobW, Cobalamin synthesis protein/P47K, score 77.90, E-value 2.1e-19 282458003273 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 282458003274 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 282458003275 active site 282458003276 catalytic tetrad [active] 282458003277 Pfam match to entry PF00248 aldo_ket_red, Aldo/keto reductase, score 131.90, E-value 1.6e-38 282458003278 3 probable transmembrane helices predicted for SAR0742 by TMHMM2.0 at aa 17-36, 41-62 and 69-91 282458003279 Signal peptide predicted for SAR0743 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.675 between residues 52 and 53; signal peptide 282458003280 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 282458003281 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 282458003282 transmembrane helices; other site 282458003283 Pfam match to entry PF00939 Na_sulph_symp, Sodium:sulfate symporter transmembrane region, score 375.80, E-value 4.5e-109 282458003284 12 probable transmembrane helices predicted for SAR0743 by TMHMM2.0 at aa 25-42, 46-65, 70-92, 122-144, 169-191, 257-279, 329-348, 363-382, 395-417, 421-443, 450-472 and 492-514 282458003285 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 282458003286 DNA photolyase; Region: DNA_photolyase; pfam00875 282458003287 Pfam match to entry PF00875 DNA_photolyase, DNA photolyase, score 274.00, E-value 1.9e-78 282458003288 3 probable transmembrane helices predicted for SAR0745 by TMHMM2.0 at aa 5-24, 28-47 and 68-90 282458003289 Predicted membrane protein [Function unknown]; Region: COG4330 282458003290 6 probable transmembrane helices predicted for SAR0746 by TMHMM2.0 at aa 7-29, 33-50, 57-79, 103-125, 132-154 and 177-199 282458003291 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 282458003292 trimer interface [polypeptide binding]; other site 282458003293 putative Zn binding site [ion binding]; other site 282458003294 Signal peptide predicted for SAR0748 by SignalP 2.0 HMM (Signal peptide probabilty 0.665) with cleavage site probability 0.651 between residues 30 and 31; signal peptide 282458003295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458003296 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282458003297 putative substrate translocation pore; other site 282458003298 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -81.20, E-value 0.00069 282458003299 12 probable transmembrane helices predicted for SAR0748 by TMHMM2.0 at aa 7-29, 40-62, 69-91, 95-117, 129-151, 156-178, 203-225, 240-259, 266-288, 292-314, 327-349 and 353-375 282458003300 Signal peptide predicted for SAR0749 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.427 between residues 37 and 38; signal peptide 282458003301 1 probable transmembrane helix predicted for SAR0749 by TMHMM2.0 at aa 10-32 282458003302 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 282458003303 putative deacylase active site [active] 282458003304 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 282458003305 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 282458003306 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 282458003307 Pfam match to entry PF00455 deoR, Bacterial regulatory proteins, deoR family, score 227.90, E-value 1.5e-64 282458003308 PS00894 Bacterial regulatory proteins, deoR family signature. 282458003309 Predicted helix-turn-helix motif with score 1665 (+4.86 SD) at aa 21-42, sequence LTLQELIDRTGCSASTIRRDLS 282458003310 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 282458003311 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 282458003312 putative substrate binding site [chemical binding]; other site 282458003313 putative ATP binding site [chemical binding]; other site 282458003314 Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 170.90, E-value 2.1e-47 282458003315 PS00584 pfkB family of carbohydrate kinases signature 2. 282458003316 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 282458003317 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282458003318 active site 282458003319 phosphorylation site [posttranslational modification] 282458003320 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 282458003321 active site 282458003322 P-loop; other site 282458003323 phosphorylation site [posttranslational modification] 282458003324 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 282458003325 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 91.70, E-value 1.5e-23 282458003326 PS00372 PTS EIIA domains phosphorylation site signature 2. 282458003327 Pfam match to entry PF02379 PTS_IIB_fruc, PTS system, Fructose specific IIB subunit, score 203.10, E-value 4.3e-57 282458003328 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 120.60, E-value 3e-32 282458003329 9 probable transmembrane helices predicted for SAR0753 by TMHMM2.0 at aa 314-336, 356-378, 391-413, 433-455, 467-489, 512-534, 547-569, 584-606 and 613-635 282458003330 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 282458003331 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 282458003332 active site 282458003333 dimer interface [polypeptide binding]; other site 282458003334 Pfam match to entry PF02612 NagA, N-acetylglucosamine-6-phosphate deacetylase, score 223.30, E-value 3.5e-63 282458003335 Signal peptide predicted for SAR0755 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.706 between residues 28 and 29; signal peptide 282458003336 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 282458003337 Domain of unknown function DUF21; Region: DUF21; pfam01595 282458003338 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 282458003339 Transporter associated domain; Region: CorC_HlyC; pfam03471 282458003340 4 probable transmembrane helices predicted for SAR0755 by TMHMM2.0 at aa 5-27, 58-80, 100-122 and 139-161 282458003341 Pfam match to entry PF01595 DUF21, Domain of unknown function DUF21, score 272.00, E-value 7.9e-78 282458003342 Pfam match to entry PF00571 CBS, CBS domain, score 36.00, E-value 8.5e-07 282458003343 Pfam match to entry PF00571 CBS, CBS domain, score 34.40, E-value 2.6e-06 282458003344 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 282458003345 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 282458003346 active site 282458003347 catalytic tetrad [active] 282458003348 Pfam match to entry PF00248 aldo_ket_red, Aldo/keto reductase, score 406.00, E-value 3.8e-120 282458003349 PS00798 Aldo/keto reductase signature 1. 282458003350 PS00062 Aldo/keto reductase signature 2. 282458003351 PS00063 Aldo/keto reductase active site signature. 282458003352 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 282458003353 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 282458003354 Ligand binding site; other site 282458003355 Putative Catalytic site; other site 282458003356 DXD motif; other site 282458003357 Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferase, score 90.90, E-value 2.6e-23 282458003358 2 probable transmembrane helices predicted for SAR0757 by TMHMM2.0 at aa 237-259 and 269-291 282458003359 Signal peptide predicted for SAR0758 by SignalP 2.0 HMM (Signal peptide probabilty 0.883) with cleavage site probability 0.657 between residues 25 and 26; signal peptide 282458003360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 282458003361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282458003362 dimer interface [polypeptide binding]; other site 282458003363 phosphorylation site [posttranslational modification] 282458003364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458003365 ATP binding site [chemical binding]; other site 282458003366 Mg2+ binding site [ion binding]; other site 282458003367 G-X-G motif; other site 282458003368 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 122.90, E-value 6e-33 282458003369 Pfam match to entry PF00512 signal, His Kinase A (phosphoacceptor) domain, score 53.90, E-value 3.5e-12 282458003370 Pfam match to entry PF00672 HAMP, HAMP domain, score 44.40, E-value 2.5e-09 282458003371 2 probable transmembrane helices predicted for SAR0758 by TMHMM2.0 at aa 9-31 and 41-63 282458003372 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282458003373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458003374 active site 282458003375 phosphorylation site [posttranslational modification] 282458003376 intermolecular recognition site; other site 282458003377 dimerization interface [polypeptide binding]; other site 282458003378 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282458003379 DNA binding site [nucleotide binding] 282458003380 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 90.20, E-value 1.2e-25 282458003381 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 122.10, E-value 1e-32 282458003382 DoxX; Region: DoxX; pfam07681 282458003383 3 probable transmembrane helices predicted for SAR0760 by TMHMM2.0 at aa 5-24, 75-97 and 99-121 282458003384 Signal peptide predicted for SAR0761 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.363 between residues 26 and 27; signal peptide 282458003385 Electron transfer DM13; Region: DM13; pfam10517 282458003386 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458003387 6 probable transmembrane helices predicted for SAR0762 by TMHMM2.0 at aa 4-21, 28-48, 53-72, 85-102, 112-134 and 155-188 282458003388 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 282458003389 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 282458003390 Pfam match to entry PF02143 Radical_activat, Radical activating enzyme, score 32.80, E-value 7.9e-06 282458003391 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 282458003392 active site 282458003393 Pfam match to entry PF01242 PTPS, 6-pyruvoyl tetrahydropterin synthase, score 24.10, E-value 1.2e-07 282458003394 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 282458003395 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 282458003396 Ligand Binding Site [chemical binding]; other site 282458003397 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 282458003398 Glutamine amidotransferase class-I; Region: GATase; pfam00117 282458003399 glutamine binding [chemical binding]; other site 282458003400 catalytic triad [active] 282458003401 Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I, score 215.70, E-value 7e-61 282458003402 PS00442 Glutamine amidotransferases class-I active site. 282458003403 aminodeoxychorismate synthase; Provisional; Region: PRK07508 282458003404 chorismate binding enzyme; Region: Chorismate_bind; cl10555 282458003405 Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme, score 181.60, E-value 8.9e-52 282458003406 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003407 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 282458003408 substrate-cofactor binding pocket; other site 282458003409 Aminotransferase class IV; Region: Aminotran_4; pfam01063 282458003410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458003411 catalytic residue [active] 282458003412 2 probable transmembrane helices predicted for SAR0769 by TMHMM2.0 at aa 2-19 and 29-51 282458003413 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 282458003414 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 282458003415 Pfam match to entry PF02682 DUF213, Uncharacterized ACR, COG2049, score 91.70, E-value 1.5e-23 282458003416 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 282458003417 Pfam match to entry PF02626 DUF183, Uncharacterized ACR, COG1984, score 162.90, E-value 5.4e-45 282458003418 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 282458003419 Signal peptide predicted for SAR0772 by SignalP 2.0 HMM (Signal peptide probabilty 0.898) with cleavage site probability 0.586 between residues 29 and 30; signal peptide 282458003420 Sulfatase; Region: Sulfatase; pfam00884 282458003421 5 probable transmembrane helices predicted for SAR0772 by TMHMM2.0 at aa 9-31, 41-63, 70-92, 122-141 and 154-173 282458003422 Pfam match to entry PF00884 Sulfatase, Sulfatase, score 28.20, E-value 8.4e-08 282458003423 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 282458003424 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282458003425 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282458003426 ABC transporter; Region: ABC_tran_2; pfam12848 282458003427 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282458003428 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 147.80, E-value 1.9e-40 282458003429 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003430 PS00211 ABC transporters family signature. 282458003431 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 144.70, E-value 1.7e-39 282458003432 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003433 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 282458003434 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282458003435 ATP binding site [chemical binding]; other site 282458003436 putative Mg++ binding site [ion binding]; other site 282458003437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282458003438 nucleotide binding region [chemical binding]; other site 282458003439 ATP-binding site [chemical binding]; other site 282458003440 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 282458003441 HRDC domain; Region: HRDC; pfam00570 282458003442 Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase, score 117.00, E-value 4.3e-36 282458003443 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 112.40, E-value 8.4e-30 282458003444 Pfam match to entry PF00570 HRDC, HRDC domain, score 26.10, E-value 0.00043 282458003445 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 282458003446 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 282458003447 Walker A/P-loop; other site 282458003448 ATP binding site [chemical binding]; other site 282458003449 Q-loop/lid; other site 282458003450 ABC transporter signature motif; other site 282458003451 Walker B; other site 282458003452 D-loop; other site 282458003453 H-loop/switch region; other site 282458003454 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 209.80, E-value 4.1e-59 282458003455 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003456 PS00211 ABC transporters family signature. 282458003457 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 282458003458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458003459 dimer interface [polypeptide binding]; other site 282458003460 conserved gate region; other site 282458003461 ABC-ATPase subunit interface; other site 282458003462 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 282458003463 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 282458003464 6 probable transmembrane helices predicted for SAR0776 by TMHMM2.0 at aa 23-45, 52-74, 78-97, 148-170, 180-202 and 209-231 282458003465 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 70.20, E-value 4.2e-17 282458003466 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282458003467 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 282458003468 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 282458003469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458003470 homodimer interface [polypeptide binding]; other site 282458003471 catalytic residue [active] 282458003472 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class-I, score 84.70, E-value 1.8e-21 282458003473 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 282458003474 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 282458003475 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 282458003476 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 282458003477 Pfam match to entry PF00781 DAGKc, Diacylglycerol kinase catalytic domain (presumed), score 39.00, E-value 1.1e-07 282458003478 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 282458003479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458003480 putative substrate translocation pore; other site 282458003481 POT family; Region: PTR2; cl17359 282458003482 13 probable transmembrane helices predicted for SAR0781 by TMHMM2.0 at aa 40-62, 69-88, 103-136, 157-176, 186-208, 231-253, 263-280, 293-310, 341-363, 376-398, 408-430, 443-462 and 472-494 282458003483 Pfam match to entry PF00854 PTR2, POT family, score 52.90, E-value 5.5e-15 282458003484 Pfam match to entry PF00854 PTR2, POT family, score 77.50, E-value 2.6e-22 282458003485 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 282458003486 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 282458003487 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 282458003488 Signal peptide predicted for SAR0783 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.634 between residues 35 and 36; signal peptide 282458003489 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6, score 36.80, E-value 4.8e-07 282458003490 10 probable transmembrane helices predicted for SAR0783 by TMHMM2.0 at aa 7-29, 39-56, 68-87, 97-114, 121-136, 146-168, 175-197, 207-229, 236-254 and 259-276 282458003491 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6, score 39.90, E-value 5.7e-08 282458003492 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 282458003493 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 282458003494 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 282458003495 Class I ribonucleotide reductase; Region: RNR_I; cd01679 282458003496 active site 282458003497 dimer interface [polypeptide binding]; other site 282458003498 catalytic residues [active] 282458003499 effector binding site; other site 282458003500 R2 peptide binding site; other site 282458003501 Pfam match to entry PF00317 ribonuc_red_lg, Ribonucleotide reductase, all-alpha domain, score 5.70, E-value 0.0019 282458003502 Pfam match to entry PF02867 ribonuc_red_lgC, Ribonucleotide reductase, barrel domain, score 388.40, E-value 7.2e-113 282458003503 PS00089 Ribonucleotide reductase large subunit signature. 282458003504 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 282458003505 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 282458003506 dimer interface [polypeptide binding]; other site 282458003507 putative radical transfer pathway; other site 282458003508 diiron center [ion binding]; other site 282458003509 tyrosyl radical; other site 282458003510 Pfam match to entry PF00268 ribonuc_red_sm, Ribonucleotide reductase, small chain, score 88.30, E-value 1.5e-22 282458003511 1 probable transmembrane helix predicted for SAR0786 by TMHMM2.0 at aa 155-177 282458003512 Signal peptide predicted for SAR0787 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.631 between residues 29 and 30; signal peptide 282458003513 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282458003514 ABC-ATPase subunit interface; other site 282458003515 dimer interface [polypeptide binding]; other site 282458003516 putative PBP binding regions; other site 282458003517 8 probable transmembrane helices predicted for SAR0787 by TMHMM2.0 at aa 9-31, 51-70, 94-116, 136-158, 184-206, 226-248, 268-290 and 295-314 282458003518 Pfam match to entry PF01032 FecCD_family, FecCD transport family, score 120.40, E-value 3.4e-32 282458003519 Signal peptide predicted for SAR0788 by SignalP 2.0 HMM (Signal peptide probabilty 0.929) with cleavage site probability 0.355 between residues 25 and 26; signal peptide 282458003520 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282458003521 ABC-ATPase subunit interface; other site 282458003522 dimer interface [polypeptide binding]; other site 282458003523 putative PBP binding regions; other site 282458003524 Pfam match to entry PF01032 FecCD_family, FecCD transport family, score 153.80, E-value 3.1e-42 282458003525 9 probable transmembrane helices predicted for SAR0788 by TMHMM2.0 at aa 10-32, 44-63, 73-95, 102-124, 129-148, 179-201, 224-246, 266-285 and 295-312 282458003526 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 282458003527 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 282458003528 Walker A/P-loop; other site 282458003529 ATP binding site [chemical binding]; other site 282458003530 Q-loop/lid; other site 282458003531 ABC transporter signature motif; other site 282458003532 Walker B; other site 282458003533 D-loop; other site 282458003534 H-loop/switch region; other site 282458003535 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 176.80, E-value 3.7e-49 282458003536 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003537 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 282458003538 Signal peptide predicted for SAR0790 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.484 between residues 28 and 29; signal peptide 282458003539 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 282458003540 putative ligand binding residues [chemical binding]; other site 282458003541 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458003542 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 139.80, E-value 4.9e-38 282458003543 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003544 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 282458003545 CHY zinc finger; Region: zf-CHY; pfam05495 282458003546 PS00190 Cytochrome c family heme-binding site signature. 282458003547 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 282458003548 FAD binding domain; Region: FAD_binding_4; pfam01565 282458003549 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 282458003550 Pfam match to entry PF02873 MurB_C, UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain, score 133.30, E-value 4.5e-36 282458003551 Pfam match to entry PF02215 MurB, UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding domain, score 195.70, E-value 7.1e-55 282458003552 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 282458003553 Signal peptide predicted for SAR0794 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.491 between residues 26 and 27; signal peptide 282458003554 1 probable transmembrane helix predicted for SAR0794 by TMHMM2.0 at aa 4-21 282458003555 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458003556 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 282458003557 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 282458003558 peptidase T; Region: peptidase-T; TIGR01882 282458003559 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 282458003560 metal binding site [ion binding]; metal-binding site 282458003561 dimer interface [polypeptide binding]; other site 282458003562 Pfam match to entry PF01546 Peptidase_M20, Peptidase M20/M25/M40, score 9.30, E-value 0.097 282458003563 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 282458003564 Pfam match to entry PF01546 Peptidase_M20, Peptidase M20/M25/M40, score 27.60, E-value 5.3e-07 282458003565 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 282458003566 Uncharacterized conserved protein [Function unknown]; Region: COG3610 282458003567 5 probable transmembrane helices predicted for SAR0798 by TMHMM2.0 at aa 4-21, 28-45, 55-72, 79-98 and 118-140 282458003568 Uncharacterized conserved protein [Function unknown]; Region: COG2966 282458003569 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 282458003570 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 282458003571 5 probable transmembrane helices predicted for SAR0799 by TMHMM2.0 at aa 120-142, 146-163, 170-188, 198-217 and 230-252 282458003572 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 282458003573 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 282458003574 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 282458003575 metal binding site [ion binding]; metal-binding site 282458003576 active site 282458003577 I-site; other site 282458003578 Pfam match to entry PF00990 GGDEF, GGDEF domain, score 115.30, E-value 1.1e-30 282458003579 6 probable transmembrane helices predicted for SAR0800 by TMHMM2.0 at aa 5-24, 31-53, 68-90, 97-119, 124-146 and 153-175 282458003580 Signal peptide predicted for SAR0801 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.920 between residues 23 and 24; signal peptide 282458003581 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 282458003582 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 282458003583 Mg++ binding site [ion binding]; other site 282458003584 putative catalytic motif [active] 282458003585 substrate binding site [chemical binding]; other site 282458003586 10 probable transmembrane helices predicted for SAR0801 by TMHMM2.0 at aa 2-24, 44-63, 70-89, 99-121, 128-150, 165-197, 204-226, 231-253, 285-304 and 309-331 282458003587 Pfam match to entry PF00953 Glycos_transf_4, Glycosyl transferase, score 227.20, E-value 2.3e-64 282458003588 Uncharacterized conserved protein [Function unknown]; Region: COG1739 282458003589 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 282458003590 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 282458003591 Pfam match to entry PF01205 UPF0029, Uncharacterized protein family UPF0029, score 195.00, E-value 1.2e-54 282458003592 PS00910 Uncharacterized protein family UPF0029 signature. 282458003593 EDD domain protein, DegV family; Region: DegV; TIGR00762 282458003594 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 282458003595 Pfam match to entry PF02645 DUF194, Uncharacterized protein, DegV family COG1307, score 173.80, E-value 2.8e-48 282458003596 DEAD-like helicases superfamily; Region: DEXDc; smart00487 282458003597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282458003598 ATP binding site [chemical binding]; other site 282458003599 putative Mg++ binding site [ion binding]; other site 282458003600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282458003601 nucleotide binding region [chemical binding]; other site 282458003602 ATP-binding site [chemical binding]; other site 282458003603 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003604 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 33.80, E-value 3.9e-06 282458003605 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 282458003606 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282458003607 active site 282458003608 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 282458003609 30S subunit binding site; other site 282458003610 Pfam match to entry PF02482 Ribosomal_S30, Sigma 54 modulation protein / S30EA ribosomal protein, score 97.80, E-value 2.1e-25 282458003611 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 282458003612 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 282458003613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 282458003614 nucleotide binding region [chemical binding]; other site 282458003615 ATP-binding site [chemical binding]; other site 282458003616 SEC-C motif; Region: SEC-C; pfam02810 282458003617 Pfam match to entry PF01043 SecA_protein, SecA protein, amino terminal region, score 1021.30, E-value 0 282458003618 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 17.20, E-value 0.0023 282458003619 PS01312 Protein secA signatures. 282458003620 Pfam match to entry PF02810 SEC-C, SEC-C motif, score 30.60, E-value 3.6e-05 282458003621 peptide chain release factor 2; Validated; Region: prfB; PRK00578 282458003622 This domain is found in peptide chain release factors; Region: PCRF; smart00937 282458003623 RF-1 domain; Region: RF-1; pfam00472 282458003624 Pfam match to entry PF00472 RF-1, Peptidyl-tRNA hydrolase domain, score 227.50, E-value 1.9e-64 282458003625 Signal peptide predicted for SAR0809 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.952 between residues 24 and 25; signal peptide 282458003626 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 282458003627 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282458003628 Surface antigen [General function prediction only]; Region: COG3942 282458003629 CHAP domain; Region: CHAP; pfam05257 282458003630 Pfam match to entry PF01476 LysM, LysM domain, score 41.60, E-value 1.7e-08 282458003631 HD domain; Region: HD_3; cl17350 282458003632 Pfam match to entry PF01966 HD, HD domain, score 15.20, E-value 0.045 282458003633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 282458003634 3 probable transmembrane helices predicted for SAR0811 by TMHMM2.0 at aa 2-21, 26-41 and 48-65 282458003635 excinuclease ABC subunit B; Provisional; Region: PRK05298 282458003636 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282458003637 ATP binding site [chemical binding]; other site 282458003638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282458003639 nucleotide binding region [chemical binding]; other site 282458003640 ATP-binding site [chemical binding]; other site 282458003641 Ultra-violet resistance protein B; Region: UvrB; pfam12344 282458003642 UvrB/uvrC motif; Region: UVR; pfam02151 282458003643 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003644 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 81.50, E-value 1.7e-20 282458003645 Pfam match to entry PF02151 UVR, UvrB/uvrC motif, score 47.70, E-value 2.6e-10 282458003646 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 282458003647 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 282458003648 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 282458003649 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 282458003650 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003651 PS00190 Cytochrome c family heme-binding site signature. 282458003652 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 10.10, E-value 3.9e-06 282458003653 PS00211 ABC transporters family signature. 282458003654 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 93.50, E-value 4.1e-24 282458003655 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003656 PS00211 ABC transporters family signature. 282458003657 HPr kinase/phosphorylase; Provisional; Region: PRK05428 282458003658 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 282458003659 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 282458003660 Hpr binding site; other site 282458003661 active site 282458003662 homohexamer subunit interaction site [polypeptide binding]; other site 282458003663 Pfam match to entry PF02603 Hpr_kinase, Hpr Serine kinase, score 489.80, E-value 2.1e-143 282458003664 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003665 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 282458003666 Pfam match to entry PF01790 LGT, Prolipoprotein diacylglyceryl transferase, score 448.10, E-value 7.5e-131 282458003667 5 probable transmembrane helices predicted for SAR0815 by TMHMM2.0 at aa 20-39, 56-75, 90-112, 204-222 and 237-256 282458003668 PS01311 Prolipoprotein diacylglyceryl transferase signature. 282458003669 putative acyl transferase; Provisional; Region: PRK10191 282458003670 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 282458003671 trimer interface [polypeptide binding]; other site 282458003672 active site 282458003673 substrate binding site [chemical binding]; other site 282458003674 CoA binding site [chemical binding]; other site 282458003675 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 8.80, E-value 60 282458003676 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 17.50, E-value 0.32 282458003677 PS00101 Hexapeptide-repeat containing-transferases signature. 282458003678 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 13.60, E-value 4.9 282458003679 TPR repeat; Region: TPR_11; pfam13414 282458003680 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 282458003681 binding surface 282458003682 TPR motif; other site 282458003683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 282458003684 TPR motif; other site 282458003685 binding surface 282458003686 Pfam match to entry PF00515 TPR, TPR Domain, score 25.10, E-value 0.0017 282458003687 Pfam match to entry PF00515 TPR, TPR Domain, score 17.60, E-value 0.3 282458003688 Predicted helix-turn-helix motif for SAR0817 with score 976.000, SD 2.51 at aa 453-474, sequence VTKKQITTWLGITQYKLNKMIE 282458003689 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 282458003690 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 282458003691 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282458003692 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 282.20, E-value 6.8e-81 282458003693 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 282458003694 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 282458003695 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003696 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003697 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 282458003698 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 282458003699 phosphate binding site [ion binding]; other site 282458003700 dimer interface [polypeptide binding]; other site 282458003701 Pfam match to entry PF01933 UPF0052, Uncharacterised protein family UPF0052, score 392.50, E-value 4.1e-114 282458003702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 282458003703 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 282458003704 Pfam match to entry PF02650 DUF199, Uncharacterized BCR, COG1481, score 430.00, E-value 2.1e-125 282458003705 Clp protease; Region: CLP_protease; pfam00574 282458003706 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 282458003707 oligomer interface [polypeptide binding]; other site 282458003708 active site residues [active] 282458003709 Pfam match to entry PF00574 CLP_protease, Clp protease, score 434.90, E-value 7.1e-127 282458003710 PS00381 Endopeptidase Clp serine active site. 282458003711 PS00382 Endopeptidase Clp histidine active site. 282458003712 malate dehydrogenase; Provisional; Region: PRK13529 282458003713 Malic enzyme, N-terminal domain; Region: malic; pfam00390 282458003714 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 282458003715 NAD(P) binding site [chemical binding]; other site 282458003716 Pfam match to entry PF00390 malic, Malic enzyme, score 787.40, E-value 5.6e-233 282458003717 PS00331 Malic enzymes signature. 282458003718 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 282458003719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 282458003720 NAD(P) binding site [chemical binding]; other site 282458003721 active site 282458003722 Signal peptide predicted for SAR0826 by SignalP 2.0 HMM (Signal peptide probabilty 0.929) with cleavage site probability 0.846 between residues 46 and 47; signal peptide 282458003723 1 probable transmembrane helix predicted for SAR0826 by TMHMM2.0 at aa 25-47 282458003724 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 282458003725 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 282458003726 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 282458003727 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 282458003728 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 282458003729 Pfam match to entry PF00044 gpdh, Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain, score 300.50, E-value 7.2e-124 282458003730 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 282458003731 Pfam match to entry PF02800 gpdh_C, Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, score 341.30, E-value 1.1e-98 282458003732 PS00211 ABC transporters family signature. 282458003733 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 282458003734 Phosphoglycerate kinase; Region: PGK; pfam00162 282458003735 substrate binding site [chemical binding]; other site 282458003736 hinge regions; other site 282458003737 ADP binding site [chemical binding]; other site 282458003738 catalytic site [active] 282458003739 Pfam match to entry PF00162 PGK, Phosphoglycerate kinase, score 697.20, E-value 7.8e-206 282458003740 PS00111 Phosphoglycerate kinase signature. 282458003741 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 282458003742 triosephosphate isomerase; Provisional; Region: PRK14565 282458003743 substrate binding site [chemical binding]; other site 282458003744 dimer interface [polypeptide binding]; other site 282458003745 catalytic triad [active] 282458003746 Pfam match to entry PF00121 TIM, Triosephosphate isomerase, score 457.40, E-value 2.1e-147 282458003747 PS00171 Triosephosphate isomerase active site. 282458003748 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 282458003749 phosphoglyceromutase; Provisional; Region: PRK05434 282458003750 PS00687 Aldehyde dehydrogenases glutamic acid active site. 282458003751 Pfam match to entry PF01676 Metalloenzyme, Metalloenzyme superfamily, score 176.80, E-value 3.5e-49 282458003752 enolase; Provisional; Region: eno; PRK00077 282458003753 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 282458003754 dimer interface [polypeptide binding]; other site 282458003755 metal binding site [ion binding]; metal-binding site 282458003756 substrate binding pocket [chemical binding]; other site 282458003757 Pfam match to entry PF00113 enolase, Enol-ase, score 851.60, E-value 2.5e-252 282458003758 PS00164 Enolase signature. 282458003759 Signal peptide predicted for SAR0833 by SignalP 2.0 HMM (Signal peptide probabilty 0.675) with cleavage site probability 0.300 between residues 39 and 40; signal peptide 282458003760 4 probable transmembrane helices predicted for SAR0833 by TMHMM2.0 at aa 12-34, 59-81, 88-110 and 120-142 282458003761 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 282458003762 Signal peptide predicted for SAR0834 by SignalP 2.0 HMM (Signal peptide probabilty 0.901) with cleavage site probability 0.546 between residues 29 and 30; signal peptide 282458003763 2 probable transmembrane helices predicted for SAR0834 by TMHMM2.0 at aa 5-22 and 53-75 282458003764 Esterase/lipase [General function prediction only]; Region: COG1647 282458003765 ribonuclease R; Region: RNase_R; TIGR02063 282458003766 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 282458003767 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 282458003768 RNB domain; Region: RNB; pfam00773 282458003769 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 282458003770 RNA binding site [nucleotide binding]; other site 282458003771 Pfam match to entry PF00773 RNB, RNB-like protein, score 440.60, E-value 1.4e-128 282458003772 PS01175 Ribonuclease II family signature. 282458003773 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 63.50, E-value 6e-16 282458003774 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 282458003775 SmpB-tmRNA interface; other site 282458003776 Pfam match to entry PF01668 SmpB, SmpB protein, score 148.20, E-value 1.4e-40 282458003777 PS01317 Protein smpB signature. 282458003778 Integral membrane protein DUF95; Region: DUF95; pfam01944 282458003779 5 probable transmembrane helices predicted for SAR0838 by TMHMM2.0 at aa 21-39, 59-81, 86-108, 123-145 and 175-197 282458003780 Signal peptide predicted for SAR0839 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.426 between residues 26 and 27; signal peptide 282458003781 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458003782 1 probable transmembrane helix predicted for SAR0840 by TMHMM2.0 at aa 7-29 282458003783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458003784 Coenzyme A binding pocket [chemical binding]; other site 282458003785 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 38.00, E-value 2.2e-07 282458003786 Signal peptide predicted for SAR0842 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.893 between residues 39 and 40; signal peptide 282458003787 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282458003788 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 282458003789 1 probable transmembrane helix predicted for SAR0842 by TMHMM2.0 at aa 16-33 282458003790 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282458003791 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282458003792 Poor database matches. Similar to N-terminal region of Staphylococcus aureus staphylocoagulase precursor SW:STC1_STAAU (P07767) (658 aa) fasta scores: E(): 1.3e-10, 27.447% id in 521 aa, and to Staphylococcus aureus secreted von Willebrand factor-binding protein precursor Vwb TR:AAK52333 (EMBL:AY032850) (508 aa) fasta scores: E(): 7.5e-119, 73.425% id in 508aa. Contains a frameshift after codon 106. Frameshift occurs at a poly A heptamer; exported protein (pseudogene) 282458003793 Signal peptide predicted for SAR0843 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.837 between residues 26 and 27 282458003794 Signal peptide predicted for SAR0845 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.653 between residues 26 and 27; signal peptide 282458003795 Signal peptide predicted for SAR0846 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.785 between residues 26 and 27; signal peptide 282458003796 Signal peptide predicted for SAR0847 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.541 between residues 29 and 30; signal peptide 282458003797 Staphylococcal nuclease homologues; Region: SNc; smart00318 282458003798 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 282458003799 Catalytic site; other site 282458003800 2 probable transmembrane helices predicted for SAR0847 by TMHMM2.0 at aa 5-27 and 36-58 282458003801 Pfam match to entry PF00565 SNase, Staphylococcal nuclease homologues, score 228.50, E-value 9.9e-65 282458003802 PS01123 Thermonuclease signature 1. 282458003803 PS01284 Thermonuclease signature 2. 282458003804 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 282458003805 DNA-binding site [nucleotide binding]; DNA binding site 282458003806 RNA-binding motif; other site 282458003807 Pfam match to entry PF00313 CSD, 'Cold-shock' DNA-binding domain, score 148.70, E-value 1e-40 282458003808 PS00352 'Cold-shock' DNA-binding domain signature. 282458003809 Signal peptide predicted for SAR0851 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.944 between residues 27 and 28; signal peptide 282458003810 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 282458003811 Signal peptide predicted for SAR0852 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.652 between residues 31 and 32; signal peptide 282458003812 2 probable transmembrane helices predicted for SAR0852 by TMHMM2.0 at aa 4-26 and 39-61 282458003813 3 probable transmembrane helices predicted for SAR0853 by TMHMM2.0 at aa 4-26, 33-55 and 60-82 282458003814 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 282458003815 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 282458003816 catalytic core [active] 282458003817 Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase, score 46.50, E-value 3.8e-14 282458003818 PS00175 Phosphoglycerate mutase phosphohistidine signature. 282458003819 Lysine efflux permease [General function prediction only]; Region: COG1279 282458003820 6 probable transmembrane helices predicted for SAR0857 by TMHMM2.0 at aa 4-26, 38-60, 70-92, 112-134, 144-165 and 178-197 282458003821 Pfam match to entry PF01810 LysE, LysE type translocator, score 75.90, E-value 8.3e-19 282458003822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 282458003823 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 282458003824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 282458003825 similar to hypothetical protein; Doubtful CDS. No significant database hits 282458003826 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 282458003827 Pfam match to entry PF02566 OsmC, OsmC-like protein, score 131.90, E-value 1.2e-35 282458003828 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 282458003829 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 282458003830 active site 282458003831 catalytic residue [active] 282458003832 dimer interface [polypeptide binding]; other site 282458003833 Pfam match to entry PF01487 DHquinase_I, Type I 3-dehydroquinase, score 164.20, E-value 2.2e-45 282458003834 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 282458003835 putative FMN binding site [chemical binding]; other site 282458003836 Pfam match to entry PF00881 Nitroreductase, Nitroreductase, score 20.50, E-value 0.00011 282458003837 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 282458003838 catalytic residues [active] 282458003839 Pfam match to entry PF00085 thiored, Thioredoxin, score 8.60, E-value 0.31 282458003840 Pfam match to entry PF00085 thiored, Thioredoxin, score 17.70, E-value 0.00052 282458003841 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 282458003842 ArsC family; Region: ArsC; pfam03960 282458003843 putative ArsC-like catalytic residues; other site 282458003844 putative TRX-like catalytic residues [active] 282458003845 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 282458003846 lipoyl attachment site [posttranslational modification]; other site 282458003847 Pfam match to entry PF01597 GCV_H, Glycine cleavage H-protein, score 236.20, E-value 4.5e-67 282458003848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 282458003849 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 282458003850 putative active site [active] 282458003851 putative metal binding site [ion binding]; other site 282458003852 Pfam match to entry PF01751 Toprim, Toprim domain, score 42.40, E-value 1e-08 282458003853 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 282458003854 catalytic residues [active] 282458003855 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 282458003856 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 282458003857 Walker A/P-loop; other site 282458003858 ATP binding site [chemical binding]; other site 282458003859 Q-loop/lid; other site 282458003860 ABC transporter signature motif; other site 282458003861 Walker B; other site 282458003862 D-loop; other site 282458003863 H-loop/switch region; other site 282458003864 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 282458003865 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 232.20, E-value 7.3e-66 282458003866 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003867 PS00211 ABC transporters family signature. 282458003868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458003869 dimer interface [polypeptide binding]; other site 282458003870 conserved gate region; other site 282458003871 ABC-ATPase subunit interface; other site 282458003872 5 probable transmembrane helices predicted for SAR0871 by TMHMM2.0 at aa 33-55, 68-90, 100-122, 160-182 and 202-224 282458003873 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 60.50, E-value 3.7e-14 282458003874 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282458003875 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 282458003876 Signal peptide predicted for SAR0872 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.889 between residues 28 and 29; signal peptide 282458003877 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 282458003878 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458003879 SaPI1 and SaPI3 att site 282458003880 Region contains imperfect repeat (gcggggccccaacacagagaatttcaaaaagaaattctacaaacaatgcaagttggg g ttgg x3) 282458003881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 282458003882 Predicted membrane protein [Function unknown]; Region: COG2035 282458003883 9 probable transmembrane helices predicted for SAR0875 by TMHMM2.0 at aa 20-39, 51-73, 83-105, 117-134, 144-166, 173-190, 195-217, 230-252 and 256-278 282458003884 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 282458003885 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 282458003886 Walker A/P-loop; other site 282458003887 ATP binding site [chemical binding]; other site 282458003888 Q-loop/lid; other site 282458003889 ABC transporter signature motif; other site 282458003890 Walker B; other site 282458003891 D-loop; other site 282458003892 H-loop/switch region; other site 282458003893 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 112.20, E-value 9.9e-30 282458003894 PS00017 ATP/GTP-binding site motif A (P-loop). 282458003895 PS00211 ABC transporters family signature. 282458003896 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 282458003897 FeS assembly protein SufD; Region: sufD; TIGR01981 282458003898 Pfam match to entry PF01458 UPF0051, Uncharacterized protein family (UPF0051), score 257.60, E-value 1.7e-73 282458003899 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 282458003900 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 282458003901 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282458003902 catalytic residue [active] 282458003903 Pfam match to entry PF00266 aminotran_5, Aminotransferase class-V, score 52.90, E-value 7.1e-12 282458003904 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 282458003905 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 282458003906 trimerization site [polypeptide binding]; other site 282458003907 active site 282458003908 Pfam match to entry PF01592 NifU_N, NifU-like N terminal domain, score 154.80, E-value 1.4e-42 282458003909 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 282458003910 FeS assembly protein SufB; Region: sufB; TIGR01980 282458003911 Pfam match to entry PF01458 UPF0051, Uncharacterized protein family (UPF0051), score 481.70, E-value 5.8e-141 282458003912 Signal peptide predicted for SAR0881 by SignalP 2.0 HMM (Signal peptide probabilty 0.841) with cleavage site probability 0.783 between residues 25 and 26; signal peptide 282458003913 3 probable transmembrane helices predicted for SAR0881 by TMHMM2.0 at aa 4-21, 42-71 and 86-103 282458003914 Signal peptide predicted for SAR0882 by SignalP 2.0 HMM (Signal peptide probabilty 0.980) with cleavage site probability 0.769 between residues 24 and 25; signal peptide 282458003915 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 282458003916 Domain of unknown function DUF21; Region: DUF21; pfam01595 282458003917 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 282458003918 Pfam match to entry PF01595 DUF21, Domain of unknown function DUF21, score 117.20, E-value 3.2e-31 282458003919 4 probable transmembrane helices predicted for SAR0882 by TMHMM2.0 at aa 2-24, 54-73, 80-102 and 117-139 282458003920 Pfam match to entry PF00571 CBS, CBS domain, score 11.50, E-value 1.8 282458003921 Pfam match to entry PF00571 CBS, CBS domain, score 17.70, E-value 0.28 282458003922 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 282458003923 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 282458003924 FMN binding site [chemical binding]; other site 282458003925 substrate binding site [chemical binding]; other site 282458003926 putative catalytic residue [active] 282458003927 PS00912 Dihydroorotate dehydrogenase signature 2. 282458003928 Uncharacterized conserved protein [Function unknown]; Region: COG1801 282458003929 Pfam match to entry PF01904 DUF72, Protein of unknown function DUF72, score 275.30, E-value 7.7e-79 282458003930 Signal peptide predicted for SAR0885 by SignalP 2.0 HMM (Signal peptide probabilty 0.774) with cleavage site probability 0.184 between residues 23 and 24; signal peptide 282458003931 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 282458003932 8 probable transmembrane helices predicted for SAR0885 by TMHMM2.0 at aa 7-29, 49-71, 83-105, 110-127, 159-181, 196-218, 223-245 and 255-274 282458003933 Pfam match to entry PF01925 DUF81, Domain of unknown function DUF81, score 25.00, E-value 5.7e-06 282458003934 Pfam match to entry PF01925 DUF81, Domain of unknown function DUF81, score 115.60, E-value 6.7e-32 282458003935 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 282458003936 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 282458003937 active site 282458003938 metal binding site [ion binding]; metal-binding site 282458003939 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 282458003940 Pfam match to entry PF01009 5_nucleotidase, 5'-nucleotidase, catalytic domain, score 84.80, E-value 5.1e-24 282458003941 lipoyl synthase; Provisional; Region: PRK05481 282458003942 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282458003943 FeS/SAM binding site; other site 282458003944 Pfam match to entry PF02546 Lipoate_synth, Lipoate synthase, score 628.60, E-value 3.5e-185 282458003945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 282458003946 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 282458003947 Uncharacterized conserved protein [Function unknown]; Region: COG2445 282458003948 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 282458003949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458003950 active site 282458003951 motif I; other site 282458003952 motif II; other site 282458003953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458003954 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 77.40, E-value 3e-19 282458003955 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 282458003956 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 282458003957 dimerization interface [polypeptide binding]; other site 282458003958 ligand binding site [chemical binding]; other site 282458003959 NADP binding site [chemical binding]; other site 282458003960 catalytic site [active] 282458003961 Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 34.50, E-value 2.4e-06 282458003962 Pfam match to entry PF02826 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 226.30, E-value 4.5e-64 282458003963 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 282458003964 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 282458003965 1 probable transmembrane helix predicted for SAR0893 by TMHMM2.0 at aa 15-37 282458003966 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 282458003967 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 282458003968 acyl-activating enzyme (AAE) consensus motif; other site 282458003969 AMP binding site [chemical binding]; other site 282458003970 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 343.00, E-value 3.2e-99 282458003971 PS00697 ATP-dependent DNA ligase AMP-binding site. 282458003972 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 282458003973 10 probable transmembrane helices predicted for SAR0895 by TMHMM2.0 at aa 4-26, 31-48, 58-80, 93-115, 130-147, 210-232, 247-269, 323-340, 345-364 and 377-399 282458003974 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 282458003975 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 282458003976 Signal peptide predicted for SAR0897 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.858 between residues 33 and 34; signal peptide 282458003977 DltD N-terminal region; Region: DltD_N; pfam04915 282458003978 DltD central region; Region: DltD_M; pfam04918 282458003979 DltD C-terminal region; Region: DltD_C; pfam04914 282458003980 1 probable transmembrane helix predicted for SAR0897 by TMHMM2.0 at aa 5-27 282458003981 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 282458003982 Pfam match to entry PF01106 NifU-like, NifU-like domain, score 133.80, E-value 3.2e-36 282458003983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 282458003984 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 282458003985 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282458003986 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 91.60, E-value 1.5e-23 282458003987 hypothetical protein; Provisional; Region: PRK13669 282458003988 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 282458003989 Pfam match to entry PF01521 HesB-like, HesB-like domain, score 156.90, E-value 3.4e-43 282458003990 PS01152 Hypothetical hesB/yadR/yfhF family signature. 282458003991 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 282458003992 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282458003993 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 91.50, E-value 1.7e-23 282458003994 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 282458003995 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 282458003996 interface (dimer of trimers) [polypeptide binding]; other site 282458003997 Substrate-binding/catalytic site; other site 282458003998 Zn-binding sites [ion binding]; other site 282458003999 Pfam match to entry PF00883 Peptidase_M17, Cytosol aminopeptidase, catalytic domain, score 415.00, E-value 6.8e-121 282458004000 PS00631 Cytosol aminopeptidase signature. 282458004001 Signal peptide predicted for SAR0905 by SignalP 2.0 HMM (Signal peptide probabilty 0.703) with cleavage site probability 0.230 between residues 30 and 31; signal peptide 282458004002 Predicted permease [General function prediction only]; Region: COG2056 282458004003 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 282458004004 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 282458004005 12 probable transmembrane helices predicted for SAR0905 by TMHMM2.0 at aa 7-29, 58-77, 98-115, 119-141, 148-170, 190-212, 233-255, 259-277, 290-312, 332-354, 361-383 and 420-437 282458004006 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 282458004007 CoenzymeA binding site [chemical binding]; other site 282458004008 subunit interaction site [polypeptide binding]; other site 282458004009 PHB binding site; other site 282458004010 Pfam match to entry PF02584 DUF157, Uncharacterized protein PaaI, COG2050, score 103.20, E-value 5.2e-27 282458004011 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 282458004012 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 282458004013 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 282458004014 Signal peptide predicted for SAR0908 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.468 between residues 24 and 25; signal peptide 282458004015 3 probable transmembrane helices predicted for SAR0908 by TMHMM2.0 at aa 7-29, 44-66 and 71-90 282458004016 Signal peptide predicted for SAR0909 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.639 between residues 32 and 33; signal peptide 282458004017 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 282458004018 3 probable transmembrane helices predicted for SAR0909 by TMHMM2.0 at aa 5-27, 34-56 and 60-82 282458004019 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 282458004020 Pfam match to entry PF01899 DUF68, Protein of unknown function DUF68, score 62.90, E-value 6.7e-15 282458004021 4 probable transmembrane helices predicted for SAR0910 by TMHMM2.0 at aa 5-22, 27-45, 52-69 and 100-122 282458004022 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 282458004023 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 282458004024 14 probable transmembrane helices predicted for SAR0911 by TMHMM2.0 at aa 6-25, 32-54, 74-96, 109-126, 131-153, 165-187, 211-233, 238-260, 275-297, 304-323, 328-350, 371-393, 408-430 and 451-470 282458004025 Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 173.00, E-value 4.8e-48 282458004026 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 282458004027 Pfam match to entry PF01898 DUF67, Protein of unknown function DUF67, score 146.30, E-value 5.3e-40 282458004028 3 probable transmembrane helices predicted for SAR0912 by TMHMM2.0 at aa 4-21, 26-48 and 68-90 282458004029 Signal peptide predicted for SAR0913 by SignalP 2.0 HMM (Signal peptide probabilty 0.871) with cleavage site probability 0.457 between residues 47 and 48; signal peptide 282458004030 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 282458004031 4 probable transmembrane helices predicted for SAR0913 by TMHMM2.0 at aa 9-31, 35-57, 70-92 and 116-138 282458004032 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 282458004033 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 282458004034 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 282458004035 21 probable transmembrane helices predicted for SAR0914 by TMHMM2.0 at aa 4-25, 30-49, 79-101, 108-127, 131-153, 166-188, 208-230, 243-265, 270-289, 302-324, 339-361, 373-395, 427-449, 470-492, 526-548, 589-611, 621-641, 646-668, 672-694, 707-729 and 767-784 282458004036 Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 238.00, E-value 1.3e-67 282458004037 Pfam match to entry PF00662 oxidored_q1_N, NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus, score 29.70, E-value 3e-06 282458004038 Kinase associated protein B; Region: KapB; pfam08810 282458004039 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 282458004040 active site 282458004041 Pfam match to entry PF00160 pro_isomerase, Cyclophilin type peptidyl-prolyl cis-trans isomerase, score 131.30, E-value 3.5e-37 282458004042 Pfam match to entry PF00160 pro_isomerase, Cyclophilin type peptidyl-prolyl cis-trans isomerase, score 49.60, E-value 2.5e-13 282458004043 general stress protein 13; Validated; Region: PRK08059 282458004044 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 282458004045 RNA binding site [nucleotide binding]; other site 282458004046 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 66.20, E-value 1.1e-16 282458004047 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 282458004048 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 282458004049 putative active site [active] 282458004050 putative FMN binding site [chemical binding]; other site 282458004051 putative substrate binding site [chemical binding]; other site 282458004052 putative catalytic residue [active] 282458004053 Pfam match to entry PF00724 oxidored_FMN, NADH:flavin oxidoreductase / NADH oxidase, score 260.80, E-value 1.9e-74 282458004054 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 282458004055 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 282458004056 inhibitor-cofactor binding pocket; inhibition site 282458004057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458004058 catalytic residue [active] 282458004059 Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III, score 626.00, E-value 1.1e-187 282458004060 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 282458004061 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 282458004062 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 282458004063 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 282458004064 NAD(P) binding site [chemical binding]; other site 282458004065 Pfam match to entry PF02812 GLFV_dehydrog_N, Glu/Leu/Phe/Val dehydrogenase, dimerisation domain, score 250.70, E-value 2e-71 282458004066 PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 282458004067 Pfam match to entry PF00208 GLFV_dehydrog, Glutamate/Leucine/Phenylalanine/Valine dehydrogenase, score 355.30, E-value 6.4e-103 282458004068 Signal peptide predicted for SAR0921 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.989 between residues 30 and 31; signal peptide 282458004069 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 282458004070 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 282458004071 active site 282458004072 catalytic site [active] 282458004073 metal binding site [ion binding]; metal-binding site 282458004074 argininosuccinate lyase; Provisional; Region: PRK00855 282458004075 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 282458004076 active sites [active] 282458004077 tetramer interface [polypeptide binding]; other site 282458004078 Pfam match to entry PF00206 lyase_1, Lyase, score 354.20, E-value 1.4e-102 282458004079 PS00163 Fumarate lyases signature. 282458004080 argininosuccinate synthase; Provisional; Region: PRK13820 282458004081 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 282458004082 ANP binding site [chemical binding]; other site 282458004083 Substrate Binding Site II [chemical binding]; other site 282458004084 Substrate Binding Site I [chemical binding]; other site 282458004085 Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase, score 739.90, E-value 2.3e-232 282458004086 PS00565 Argininosuccinate synthase signature 2. 282458004087 PS00564 Argininosuccinate synthase signature 1. 282458004088 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 282458004089 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 282458004090 active site 282458004091 dimer interface [polypeptide binding]; other site 282458004092 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 282458004093 dimer interface [polypeptide binding]; other site 282458004094 active site 282458004095 Pfam match to entry PF00342 PGI, Phosphoglucose isomerase, score 543.30, E-value 1.6e-159 282458004096 PS00765 Phosphoglucose isomerase signature 1. 282458004097 Uncharacterized conserved protein [Function unknown]; Region: COG0398 282458004098 5 probable transmembrane helices predicted for SAR0925 by TMHMM2.0 at aa 21-43, 48-70, 100-122, 132-151 and 156-178 282458004099 Signal peptide predicted for SAR0926 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.833 between residues 30 and 31; signal peptide 282458004100 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 282458004101 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 282458004102 Catalytic site [active] 282458004103 Pfam match to entry PF00461 Peptidase_S26, Signal peptidase I, score 25.00, E-value 1.1e-06 282458004104 1 probable transmembrane helix predicted for SAR0926 by TMHMM2.0 at aa 7-29 282458004105 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 282458004106 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 282458004107 Catalytic site [active] 282458004108 Pfam match to entry PF00461 Peptidase_S26, Signal peptidase I, score 182.20, E-value 6.8e-55 282458004109 1 probable transmembrane helix predicted for SAR0927 by TMHMM2.0 at aa 5-27 282458004110 PS00501 Signal peptidases I serine active site. 282458004111 PS00760 Signal peptidases I lysine active site. 282458004112 PS00761 Signal peptidases I signature 3. 282458004113 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 282458004114 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 282458004115 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004116 Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase, score 15.40, E-value 0.002 282458004117 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 282458004118 Part of AAA domain; Region: AAA_19; pfam13245 282458004119 Family description; Region: UvrD_C_2; pfam13538 282458004120 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 282458004121 Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase, score 128.30, E-value 1.4e-34 282458004122 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004123 Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase, score 172.40, E-value 7.4e-48 282458004124 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 282458004125 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 282458004126 Pfam match to entry PF01557 FAA_hydrolase, Fumarylacetoacetate (FAA) hydrolase, score 193.60, E-value 3.1e-54 282458004127 hypothetical protein; Provisional; Region: PRK13673 282458004128 Signal peptide predicted for SAR0931 by SignalP 2.0 HMM (Signal peptide probabilty 0.710) with cleavage site probability 0.508 between residues 26 and 27; signal peptide 282458004129 4 probable transmembrane helices predicted for SAR0931 by TMHMM2.0 at aa 5-24, 37-56, 66-88 and 100-122 282458004130 Insertion sequence IS1272 282458004131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 282458004132 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458004133 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 282458004134 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458004135 coenzyme A disulfide reductase; Provisional; Region: PRK13512 282458004136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 282458004137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282458004138 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 282458004139 Pfam match to entry PF02852 pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 71.60, E-value 1.7e-17 282458004140 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 230.20, E-value 2.9e-65 282458004141 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 282458004142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458004143 active site 282458004144 motif I; other site 282458004145 motif II; other site 282458004146 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458004147 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 19.90, E-value 0.0044 282458004148 PS01228 Hypothetical cof family signature 1. 282458004149 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 282458004150 Pfam match to entry PF01883 DUF59, Domain of unknown function DUF59, score 111.90, E-value 1.2e-29 282458004151 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 282458004152 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 282458004153 catalytic triad [active] 282458004154 catalytic triad [active] 282458004155 oxyanion hole [active] 282458004156 10 probable transmembrane helices predicted for SAR0937 by TMHMM2.0 at aa 19-36, 41-63, 84-103, 148-170, 177-199, 237-259, 272-294, 309-328, 335-357 and 377-399 282458004157 Pfam match to entry PF01757 DUF33, Domain of unknown function DUF33, score 38.80, E-value 5.5e-10 282458004158 Pfam match to entry PF01757 DUF33, Domain of unknown function DUF33, score 22.90, E-value 1.7e-05 282458004159 Pfam match to entry PF01757 DUF33, Domain of unknown function DUF33, score 23.00, E-value 1.5e-05 282458004160 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 282458004161 Clp amino terminal domain; Region: Clp_N; pfam02861 282458004162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458004163 Walker A motif; other site 282458004164 ATP binding site [chemical binding]; other site 282458004165 Walker B motif; other site 282458004166 arginine finger; other site 282458004167 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 282458004168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458004169 Walker A motif; other site 282458004170 ATP binding site [chemical binding]; other site 282458004171 Walker B motif; other site 282458004172 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 282458004173 Pfam match to entry PF02861 Clp_N, Clp amino terminal domain, score 23.60, E-value 0.0046 282458004174 Pfam match to entry PF02861 Clp_N, Clp amino terminal domain, score 19.30, E-value 0.022 282458004175 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA), score 41.80, E-value 1.5e-08 282458004176 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004177 PS00870 Chaperonins clpA/B signature 1. 282458004178 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA), score 2.10, E-value 0.0019 282458004179 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004180 PS00871 Chaperonins clpA/B signature 2. 282458004181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 282458004182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 282458004183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 282458004184 dimerization interface [polypeptide binding]; other site 282458004185 Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 79.10, E-value 9.1e-20 282458004186 PS00044 Bacterial regulatory proteins, lysR family signature. 282458004187 Predicted helix-turn-helix motif with score 995 (+2.58 SD) at aa 16-37, sequence LNYRLASEEINLTIPSIHKQIK 282458004188 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 282458004189 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 282458004190 active site 282458004191 catalytic residues [active] 282458004192 metal binding site [ion binding]; metal-binding site 282458004193 Pfam match to entry PF00682 HMGL-like, HMGL-like, score 178.10, E-value 1.4e-49 282458004194 PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 282458004195 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 282458004196 Pfam match to entry PF01300 Sua5_yciO_yrdC, SUA5/yciO/yrdC family, score 33.30, E-value 6.4e-07 282458004197 10 probable transmembrane helices predicted for SAR0942 by TMHMM2.0 at aa 13-30, 35-54, 79-101, 133-150, 157-176, 200-222, 235-254, 269-291, 312-334 and 339-361 282458004198 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 282458004199 substrate binding site [chemical binding]; other site 282458004200 Signal peptide predicted for SAR0944 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.968 between residues 30 and 31; signal peptide 282458004201 MAP domain; Region: MAP; pfam03642 282458004202 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 282458004203 2 probable transmembrane helices predicted for SAR0945 by TMHMM2.0 at aa 4-26 and 31-53 282458004204 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 282458004205 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 282458004206 dimer interface [polypeptide binding]; other site 282458004207 active site 282458004208 CoA binding pocket [chemical binding]; other site 282458004209 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 282458004210 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 282458004211 dimer interface [polypeptide binding]; other site 282458004212 active site 282458004213 Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase, N-terminal domain, score 286.90, E-value 2.6e-82 282458004214 Pfam match to entry PF02801 ketoacyl-synt_C, Beta-ketoacyl synthase, C-terminal domain, score 249.20, E-value 5.9e-71 282458004215 Signal peptide predicted for SAR0948 by SignalP 2.0 HMM (Signal peptide probabilty 0.608) with cleavage site probability 0.388 between residues 23 and 24; signal peptide 282458004216 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 282458004217 3 probable transmembrane helices predicted for SAR0948 by TMHMM2.0 at aa 5-27, 34-56 and 100-122 282458004218 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 282458004219 Signal peptide predicted for SAR0949 by SignalP 2.0 HMM (Signal peptide probabilty 0.978) with cleavage site probability 0.872 between residues 42 and 43; signal peptide 282458004220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458004221 dimer interface [polypeptide binding]; other site 282458004222 conserved gate region; other site 282458004223 putative PBP binding loops; other site 282458004224 ABC-ATPase subunit interface; other site 282458004225 6 probable transmembrane helices predicted for SAR0949 by TMHMM2.0 at aa 5-27, 97-119, 132-154, 164-186, 225-247 and 275-297 282458004226 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 18.70, E-value 0.014 282458004227 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 282458004228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458004229 dimer interface [polypeptide binding]; other site 282458004230 conserved gate region; other site 282458004231 putative PBP binding loops; other site 282458004232 ABC-ATPase subunit interface; other site 282458004233 6 probable transmembrane helices predicted for SAR0950 by TMHMM2.0 at aa 64-86, 156-178, 191-213, 217-236, 267-289 and 320-342 282458004234 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 50.00, E-value 5.3e-11 282458004235 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 282458004236 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282458004237 Walker A/P-loop; other site 282458004238 ATP binding site [chemical binding]; other site 282458004239 Q-loop/lid; other site 282458004240 ABC transporter signature motif; other site 282458004241 Walker B; other site 282458004242 D-loop; other site 282458004243 H-loop/switch region; other site 282458004244 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 282458004245 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 222.40, E-value 6.7e-63 282458004246 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004247 PS00211 ABC transporters family signature. 282458004248 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 282458004249 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282458004250 Walker A/P-loop; other site 282458004251 ATP binding site [chemical binding]; other site 282458004252 Q-loop/lid; other site 282458004253 ABC transporter signature motif; other site 282458004254 Walker B; other site 282458004255 D-loop; other site 282458004256 H-loop/switch region; other site 282458004257 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 282458004258 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 204.20, E-value 2e-57 282458004259 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004260 PS00211 ABC transporters family signature. 282458004261 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 282458004262 Signal peptide predicted for SAR0953 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.561 between residues 22 and 23; signal peptide 282458004263 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 282458004264 peptide binding site [polypeptide binding]; other site 282458004265 Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 276.00, E-value 4.8e-79 282458004266 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458004267 Similar to Lactococcus lactis oligopeptide-binding protein OppA SW:OPPA_LACLA (Q07741) (600 aa) fasta scores: E(): 1e-27, 27.163% id in 578 aa, and to Bacillus halodurans oligopeptide ABC transporter BH3636 TR:Q9K6U0 (EMBL:AP001519) (610 aa) fasta scores: E(): 7.2e-53, 31.485% id in 559 aa. CDS is disrupted by the insertion of an IS element after codon 82;transport system extracellular binding lipoprotein (pseudogene) 282458004268 Signal peptide predicted for SAR0954 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.416 between residues 27 and 28 282458004269 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458004270 insertion sequence ISX 282458004271 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 282458004272 Helix-turn-helix domain; Region: HTH_38; pfam13936 282458004273 Integrase core domain; Region: rve; pfam00665 282458004274 Pfam match to entry PF00665 rve, Integrase core domain, score 119.70, E-value 2.1e-33 282458004275 PS01043 Transposases, IS30 family, signature. 282458004276 Predicted helix-turn-helix motif with score 1647 (+4.80 SD) at aa 22-43, sequence YSLRSIARKLKRSVSTISREIS 282458004277 Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 77.50, E-value 7.9e-21 282458004278 Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 5.10, E-value 1.2 282458004279 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 282458004280 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282458004281 Walker A/P-loop; other site 282458004282 ATP binding site [chemical binding]; other site 282458004283 Q-loop/lid; other site 282458004284 ABC transporter signature motif; other site 282458004285 Walker B; other site 282458004286 D-loop; other site 282458004287 H-loop/switch region; other site 282458004288 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 282458004289 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 214.90, E-value 1.2e-60 282458004290 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004291 PS00211 ABC transporters family signature. 282458004292 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 282458004293 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282458004294 Walker A/P-loop; other site 282458004295 ATP binding site [chemical binding]; other site 282458004296 Q-loop/lid; other site 282458004297 ABC transporter signature motif; other site 282458004298 Walker B; other site 282458004299 D-loop; other site 282458004300 H-loop/switch region; other site 282458004301 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 282458004302 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 181.30, E-value 1.5e-50 282458004303 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004304 PS00211 ABC transporters family signature. 282458004305 Similar to the N-terminal regions of Bacillus subtilis oligopeptide ABC transporter permease AppB SW:APPB_BACSU (P42062) (317 aa) fasta scores: E(): 7.6e-20, 36.923% id in 195 aa, and Bacillus halodurans oligopeptide ABC transporter BH3638 TR:Q9K6T8 (EMBL:AP001519) (322 aa) fasta scores: E(): 4.7e-31, 44.712% id in 208 aa. CDS contains an internal deletion relative orthologues. C-terminus of the CDS has similarity to the C-terminal region of orthologues; oligopeptide ABC transporter permease (pseudogene) 282458004306 Signal peptide predicted for SAR0959 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.441 between residues 36 and 37 282458004307 4 probable transmembrane helices predicted for SAR0959 by TMHMM2.0 at aa 9-31, 99-121, 134-156 and 187-209 282458004308 Signal peptide predicted for SAR0960 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.270 between residues 49 and 50; signal peptide 282458004309 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 282458004310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458004311 dimer interface [polypeptide binding]; other site 282458004312 conserved gate region; other site 282458004313 putative PBP binding loops; other site 282458004314 ABC-ATPase subunit interface; other site 282458004315 6 probable transmembrane helices predicted for SAR0960 by TMHMM2.0 at aa 21-43, 88-110, 117-139, 149-171, 202-224 and 261-283 282458004316 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 38.80, E-value 1.3e-07 282458004317 insertion sequence ISY 282458004318 HTH-like domain; Region: HTH_21; pfam13276 282458004319 Integrase core domain; Region: rve; pfam00665 282458004320 Integrase core domain; Region: rve_3; cl15866 282458004321 Pfam match to entry PF00665 rve, Integrase core domain, score 95.20, E-value 2.4e-26 282458004322 insertion sequence ISZ 282458004323 Transposase; Region: HTH_Tnp_1; cl17663 282458004324 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 282458004325 Homeodomain-like domain; Region: HTH_23; cl17451 282458004326 Predicted helix-turn-helix motif with score 992 (+2.57 SD) at aa 155-176, sequence QSYREVAEHFNISYGQFTSGFI 282458004327 Insertion sequence IS1272 282458004328 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 282458004329 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458004330 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 282458004331 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458004332 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 282458004333 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 282458004334 active site 282458004335 HIGH motif; other site 282458004336 dimer interface [polypeptide binding]; other site 282458004337 KMSKS motif; other site 282458004338 Pfam match to entry PF00579 tRNA-synt_1b, tRNA synthetases class I (W and Y), score 345.80, E-value 4.8e-100 282458004339 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282458004340 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 282458004341 ArsC family; Region: ArsC; pfam03960 282458004342 putative catalytic residues [active] 282458004343 thiol/disulfide switch; other site 282458004344 adaptor protein; Provisional; Region: PRK02315 282458004345 Competence protein CoiA-like family; Region: CoiA; cl11541 282458004346 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282458004347 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 282458004348 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 282458004349 active site 282458004350 Zn binding site [ion binding]; other site 282458004351 Pfam match to entry PF01432 Peptidase_M3, Peptidase M3, score 437.90, E-value 8.7e-128 282458004352 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 282458004353 Thioredoxin; Region: Thioredoxin_5; pfam13743 282458004354 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 282458004355 apolar tunnel; other site 282458004356 heme binding site [chemical binding]; other site 282458004357 dimerization interface [polypeptide binding]; other site 282458004358 Pfam match to entry PF01152 Bac_globin, Protozoan/cyanobacterial globin, score -4.20, E-value 7.3e-05 282458004359 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 282458004360 putative active site [active] 282458004361 putative metal binding residues [ion binding]; other site 282458004362 signature motif; other site 282458004363 putative triphosphate binding site [ion binding]; other site 282458004364 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 282458004365 synthetase active site [active] 282458004366 NTP binding site [chemical binding]; other site 282458004367 metal binding site [ion binding]; metal-binding site 282458004368 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 282458004369 ATP-NAD kinase; Region: NAD_kinase; pfam01513 282458004370 Pfam match to entry PF01513 DUF15, Domain of unknown function DUF15, score 230.60, E-value 2.3e-65 282458004371 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 282458004372 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 282458004373 active site 282458004374 Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase, score 132.10, E-value 1e-35 282458004375 PS01129 Rlu family of pseudouridine synthase signature. 282458004376 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 282458004377 MgtE intracellular N domain; Region: MgtE_N; smart00924 282458004378 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 282458004379 Divalent cation transporter; Region: MgtE; pfam01769 282458004380 Pfam match to entry PF00571 CBS, CBS domain, score 38.20, E-value 1.8e-07 282458004381 Pfam match to entry PF00571 CBS, CBS domain, score 38.00, E-value 2.1e-07 282458004382 5 probable transmembrane helices predicted for SAR0976 by TMHMM2.0 at aa 295-312, 322-341, 369-391, 396-418 and 431-453 282458004383 Pfam match to entry PF01769 MgtE, Divalent cation transporter, score 127.90, E-value 1.8e-34 282458004384 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 282458004385 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 282458004386 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 282458004387 TrkA-N domain; Region: TrkA_N; pfam02254 282458004388 TrkA-C domain; Region: TrkA_C; pfam02080 282458004389 Pfam match to entry PF00999 Na_H_Exchanger, Sodium/hydrogen exchanger family, score 37.10, E-value 4.1e-07 282458004390 12 probable transmembrane helices predicted for SAR0977 by TMHMM2.0 at aa 4-20, 27-49, 54-76, 98-120, 130-149, 162-184, 190-212, 233-262, 277-299, 306-328, 338-355 and 368-387 282458004391 Pfam match to entry PF02254 KTN, KTN NAD-binding domain, score 15.90, E-value 0.0011 282458004392 Pfam match to entry PF02080 TrkA, Potassium channel, score 36.40, E-value 6.6e-07 282458004393 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 282458004394 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 282458004395 NAD binding site [chemical binding]; other site 282458004396 homotetramer interface [polypeptide binding]; other site 282458004397 homodimer interface [polypeptide binding]; other site 282458004398 substrate binding site [chemical binding]; other site 282458004399 active site 282458004400 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 61.10, E-value 2.3e-14 282458004401 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 282458004402 Domain of unknown function DUF20; Region: UPF0118; pfam01594 282458004403 9 probable transmembrane helices predicted for SAR0979 by TMHMM2.0 at aa 5-23, 30-52, 72-94, 155-177, 213-235, 242-261, 265-287, 299-318 and 323-345 282458004404 Pfam match to entry PF01594 UPF0118, Domain of unknown function DUF20, score 212.40, E-value 7e-60 282458004405 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 282458004406 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 282458004407 10 probable transmembrane helices predicted for SAR0980 by TMHMM2.0 at aa 18-36, 75-97, 143-160, 181-203, 207-229, 236-258, 296-318, 381-403, 418-440 and 447-469 282458004408 Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family, score 545.90, E-value 2.8e-160 282458004409 PS00873 Sodium:alanine symporter family signature. 282458004410 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 282458004411 Putative esterase; Region: Esterase; pfam00756 282458004412 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 282458004413 minor groove reading motif; other site 282458004414 helix-hairpin-helix signature motif; other site 282458004415 substrate binding pocket [chemical binding]; other site 282458004416 active site 282458004417 Possible gene remnant. Similar to an internal region of Enterococcus faecium transposase TR:Q47812 (EMBL:L38972) (319 aa) fasta scores: E(): 0.042, 43.182% id in 44 aa;transposase (fragment) 282458004418 hypothetical protein; Provisional; Region: PRK13679 282458004419 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 282458004420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282458004421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458004422 putative substrate translocation pore; other site 282458004423 12 probable transmembrane helices predicted for SAR0986 by TMHMM2.0 at aa 13-35, 39-61, 80-99, 104-126, 139-161, 166-184, 211-233, 246-268, 275-297, 302-324, 337-359 and 369-391 282458004424 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 282458004425 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 282458004426 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 282458004427 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 282458004428 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 282458004429 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 282458004430 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 282458004431 Pfam match to entry PF01225 Mur_ligase, Mur ligase, catalytic domain, score 274.90, E-value 2.8e-80 282458004432 Pfam match to entry PF02875 Mur_ligase_C, Mur ligase, glutamate ligase domain, score 100.10, E-value 4.5e-26 282458004433 YueH-like protein; Region: YueH; pfam14166 282458004434 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 282458004435 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 282458004436 G1 box; other site 282458004437 putative GEF interaction site [polypeptide binding]; other site 282458004438 GTP/Mg2+ binding site [chemical binding]; other site 282458004439 Switch I region; other site 282458004440 G2 box; other site 282458004441 G3 box; other site 282458004442 Switch II region; other site 282458004443 G4 box; other site 282458004444 G5 box; other site 282458004445 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 282458004446 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family, score 366.40, E-value 3e-106 282458004447 PS00301 GTP-binding elongation factors signature. 282458004448 Signal peptide predicted for SAR0991 by SignalP 2.0 HMM (Signal peptide probabilty 0.660) with cleavage site probability 0.481 between residues 26 and 27; signal peptide 282458004449 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 282458004450 7 probable transmembrane helices predicted for SAR0991 by TMHMM2.0 at aa 5-27, 48-70, 74-93, 133-155, 170-192, 205-227 and 237-259 282458004451 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 282458004452 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 282458004453 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 282458004454 1 probable transmembrane helix predicted for SAR0992 by TMHMM2.0 at aa 405-427 282458004455 Pfam match to entry PF00089 trypsin, Trypsin, score 42.40, E-value 1.3e-12 282458004456 Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF)., score 13.10, E-value 0.061 282458004457 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 282458004458 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 282458004459 Pfam match to entry PF02386 TrkH, Sodium transport protein, score 366.50, E-value 2.8e-106 282458004460 10 probable transmembrane helices predicted for SAR0993 by TMHMM2.0 at aa 15-37, 50-68, 78-100, 128-150, 193-215, 228-250, 312-334, 355-377, 382-404 and 413-435 282458004461 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004462 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 282458004463 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 282458004464 active site 282458004465 metal binding site [ion binding]; metal-binding site 282458004466 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 282458004467 Pfam match to entry PF01009 5_nucleotidase, 5'-nucleotidase, catalytic domain, score 93.10, E-value 1.9e-26 282458004468 1 probable transmembrane helix predicted for SAR0994 by TMHMM2.0 at aa 48-70 282458004469 Pfam match to entry PF02872 5_nucleotidaseC, 5'-nucleotidase, C-terminal domain, score -14.40, E-value 0.0022 282458004470 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 282458004471 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 282458004472 IDEAL domain; Region: IDEAL; pfam08858 282458004473 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 282458004474 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 282458004475 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 282458004476 Pfam match to entry PF02539 Lipoate_A, Lipoate-protein ligase A, score 254.00, E-value 2e-72 282458004477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 282458004478 CAAX protease self-immunity; Region: Abi; pfam02517 282458004479 7 probable transmembrane helices predicted for SAR0999 by TMHMM2.0 at aa 7-27, 32-50, 63-85, 105-122, 135-154, 158-175 and 182-199 282458004480 Pfam match to entry PF02517 Abi, CAAX amino terminal protease, score 4.80, E-value 0.015 282458004481 Signal peptide predicted for SAR1001 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.738 between residues 28 and 29; signal peptide 282458004482 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 282458004483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 282458004484 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 282458004485 7 probable transmembrane helices predicted for SAR1002 by TMHMM2.0 at aa 6-25, 162-181, 213-235, 242-264, 551-573, 594-616 and 620-642 282458004486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 282458004487 Signal peptide predicted for SAR1003 by SignalP 2.0 HMM (Signal peptide probabilty 0.719) with cleavage site probability 0.425 between residues 29 and 30; signal peptide 282458004488 1 probable transmembrane helix predicted for SAR1003 by TMHMM2.0 at aa 5-27 282458004489 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282458004490 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 282458004491 Walker A/P-loop; other site 282458004492 ATP binding site [chemical binding]; other site 282458004493 Q-loop/lid; other site 282458004494 ABC transporter signature motif; other site 282458004495 Walker B; other site 282458004496 D-loop; other site 282458004497 H-loop/switch region; other site 282458004498 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 159.40, E-value 6.1e-44 282458004499 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004500 PS00211 ABC transporters family signature. 282458004501 3 probable transmembrane helices predicted for SAR1005 by TMHMM2.0 at aa 20-42, 46-68 and 75-94 282458004502 Similar to Bacillus subtilis probable UDP-glucose:polyglycerol phosphate glucosyltransferase TagE SW:TAGE_BACSU (P13484) (673 aa) fasta scores: E(): 5.2e-19, 26.453% id in 499 aa, and to Lactococcus lactis lipopolysaccharide biosynthesis protein YohJ TR:Q9CFL4 (EMBL:AE006375) (506 aa) fasta scores: E(): 9.6e-11, 24.033% id in 491 aa. Contains a frameshift after codon 371; glycosyl transferases (pseudogene) 282458004503 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 39.90, E-value 7.8e-10 282458004504 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 72.90, E-value 4.8e-19 282458004505 Predicted membrane protein [Function unknown]; Region: COG2259 282458004506 2 probable transmembrane helices predicted for SAR1010 by TMHMM2.0 at aa 31-53 and 58-80 282458004507 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 282458004508 Signal peptide predicted for SAR1011 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.364 between residues 25 and 26; signal peptide 282458004509 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 282458004510 siderophore binding site; other site 282458004511 1 probable transmembrane helix predicted for SAR1011 by TMHMM2.0 at aa 5-24 282458004512 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458004513 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 189.00, E-value 7.6e-53 282458004514 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 282458004515 2 probable transmembrane helices predicted for SAR1013 by TMHMM2.0 at aa 7-25 and 35-57 282458004516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458004517 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 282458004518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 282458004519 Coenzyme A binding pocket [chemical binding]; other site 282458004520 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 56.50, E-value 5.8e-13 282458004521 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 282458004522 UbiA prenyltransferase family; Region: UbiA; pfam01040 282458004523 9 probable transmembrane helices predicted for SAR1015 by TMHMM2.0 at aa 21-43, 48-70, 101-123, 127-149, 154-176, 181-203, 224-246, 250-272 and 293-310 282458004524 Pfam match to entry PF01040 UbiA, UbiA prenyltransferase, score 100.60, E-value 3.1e-26 282458004525 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004526 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 282458004527 isochorismate synthases; Region: isochor_syn; TIGR00543 282458004528 Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme, score 182.20, E-value 5.9e-52 282458004529 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 282458004530 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 282458004531 dimer interface [polypeptide binding]; other site 282458004532 tetramer interface [polypeptide binding]; other site 282458004533 PYR/PP interface [polypeptide binding]; other site 282458004534 TPP binding site [chemical binding]; other site 282458004535 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 282458004536 TPP-binding site; other site 282458004537 Pfam match to entry PF02776 TPP_enzymes_N, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score -55.30, E-value 0.0032 282458004538 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 282458004539 PGAP1-like protein; Region: PGAP1; pfam07819 282458004540 Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold, score 95.50, E-value 1.1e-24 282458004541 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 282458004542 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 282458004543 substrate binding site [chemical binding]; other site 282458004544 oxyanion hole (OAH) forming residues; other site 282458004545 trimer interface [polypeptide binding]; other site 282458004546 Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase, score 273.70, E-value 2.4e-78 282458004547 Staphostatin B; Region: Staphostatin_B; pfam09023 282458004548 Signal peptide predicted for SAR1021 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.795 between residues 36 and 37; signal peptide 282458004549 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 282458004550 1 probable transmembrane helix predicted for SAR1021 by TMHMM2.0 at aa 7-29 282458004551 Signal peptide predicted for SAR1022 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.476 between residues 34 and 35; signal peptide 282458004552 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 282458004553 Pfam match to entry PF00089 trypsin, Trypsin, score 76.80, E-value 1.6e-23 282458004554 PS00673 Serine proteases, V8 family, serine active site. 282458004555 PS00672 Serine proteases, V8 family, histidine active site. 282458004556 aminotransferase A; Validated; Region: PRK07683 282458004557 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 282458004558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458004559 homodimer interface [polypeptide binding]; other site 282458004560 catalytic residue [active] 282458004561 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class-I, score 150.10, E-value 3.8e-41 282458004562 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 282458004563 Similar to Rhizobium loti nodulation protein NolL SW:NOLL_RHILO (Q52778) (373 aa) fasta scores: E(): 4.1e-06, 24.085% id in 328 aa, and to Bacillus subtilis hypothetical protein YkrP TR:O31660 (EMBL:Z99111) (340 aa) fasta scores: E(): 2e-35, 34.146% id in 328 aa. Contains a frameshift after codon 4; membrane protein (pseudogene) 282458004564 10 probable transmembrane helices predicted for SAR1024 by TMHMM2.0 at aa 7-29, 39-61, 73-95, 110-129, 136-153, 157-175, 188-210, 236-255, 262-281 and 296-318 282458004565 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 282458004566 MarR family; Region: MarR; pfam01047 282458004567 Pfam match to entry PF01047 MarR, MarR family, score 104.20, E-value 2.5e-27 282458004568 Predicted helix-turn-helix motif with score 1295 (+3.60 SD) at aa 46-67, sequence LSQYDLTMKISREQSIVSRWIK 282458004569 Signal peptide predicted for SAR1026 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 29 and 30; signal peptide 282458004570 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 282458004571 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 282458004572 amidase catalytic site [active] 282458004573 Zn binding residues [ion binding]; other site 282458004574 substrate binding site [chemical binding]; other site 282458004575 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 282458004576 Lysozyme subfamily 2; Region: LYZ2; smart00047 282458004577 Pfam match to entry PF01832 Amidase_4, N-acetylmuramoyl-L-alanine amidase, score 223.60, E-value 2.9e-63 282458004578 Pfam match to entry PF01510 Amidase_2, N-acetylmuramoyl-L-alanine amidase, score 222.10, E-value 8.4e-63 282458004579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458004580 Coenzyme A binding pocket [chemical binding]; other site 282458004581 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 81.80, E-value 1.4e-20 282458004582 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 282458004583 Transcriptional regulator [Transcription]; Region: LytR; COG1316 282458004584 Signal peptide predicted for SAR1029 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.647 between residues 36 and 37; signal peptide 282458004585 1 probable transmembrane helix predicted for SAR1029 by TMHMM2.0 at aa 7-28 282458004586 Signal peptide predicted for SAR1030 by SignalP 2.0 HMM (Signal peptide probabilty 0.789) with cleavage site probability 0.462 between residues 35 and 36; signal peptide 282458004587 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 282458004588 Beta-lactamase; Region: Beta-lactamase; pfam00144 282458004589 1 probable transmembrane helix predicted for SAR1030 by TMHMM2.0 at aa 7-26 282458004590 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 282458004591 Signal peptide predicted for SAR1031 by SignalP 2.0 HMM (Signal peptide probabilty 0.949) with cleavage site probability 0.757 between residues 34 and 35; signal peptide 282458004592 3 probable transmembrane helices predicted for SAR1031 by TMHMM2.0 at aa 9-31, 36-58 and 70-89 282458004593 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 282458004594 Subunit I/III interface [polypeptide binding]; other site 282458004595 Subunit III/IV interface [polypeptide binding]; other site 282458004596 5 probable transmembrane helices predicted for SAR1032 by TMHMM2.0 at aa 20-42, 62-84, 91-113, 133-155 and 176-198 282458004597 Pfam match to entry PF00510 COX3, Cytochrome c oxidase subunit III, score -148.30, E-value 1.8e-06 282458004598 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 282458004599 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 282458004600 D-pathway; other site 282458004601 Putative ubiquinol binding site [chemical binding]; other site 282458004602 Low-spin heme (heme b) binding site [chemical binding]; other site 282458004603 Putative water exit pathway; other site 282458004604 Binuclear center (heme o3/CuB) [ion binding]; other site 282458004605 K-pathway; other site 282458004606 Putative proton exit pathway; other site 282458004607 15 probable transmembrane helices predicted for SAR1033 by TMHMM2.0 at aa 15-37, 56-78, 101-123, 136-158, 186-208, 228-250, 275-297, 310-332, 342-364, 377-399, 414-436, 449-471, 486-508, 587-604 and 608-627 282458004608 Pfam match to entry PF00115 COX1, Cytochrome C and Quinol oxidase polypeptide I, score 830.50, E-value 5.8e-246 282458004609 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 282458004610 Signal peptide predicted for SAR1034 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.499 between residues 28 and 29; signal peptide 282458004611 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 282458004612 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 282458004613 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 282458004614 3 probable transmembrane helices predicted for SAR1034 by TMHMM2.0 at aa 7-26, 41-63 and 84-106 282458004615 Pfam match to entry PF02790 COX2_TM, Cytochrome C oxidase subunit II, transmembrane domain, score 21.80, E-value 0.00011 282458004616 Signal peptide predicted for SAR1035 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.515 between residues 24 and 25; signal peptide 282458004617 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 282458004618 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 282458004619 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 282458004620 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 282458004621 homodimer interface [polypeptide binding]; other site 282458004622 NADP binding site [chemical binding]; other site 282458004623 substrate binding site [chemical binding]; other site 282458004624 Pfam match to entry PF02882 THF_DHG_CYH_C, Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain, score 291.70, E-value 9.3e-84 282458004625 Pfam match to entry PF00763 THF_DHG_CYH, Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain, score 208.50, E-value 1e-58 282458004626 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 282458004627 Pfam match to entry PF00731 AIRC, AIR carboxylase, score 302.50, E-value 5.2e-87 282458004628 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 282458004629 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 282458004630 NAD binding site [chemical binding]; other site 282458004631 ATP-grasp domain; Region: ATP-grasp; pfam02222 282458004632 Pfam match to entry PF02222 ATP-grasp, ATP-grasp domain, score 78.90, E-value 1e-19 282458004633 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 282458004634 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 282458004635 ATP binding site [chemical binding]; other site 282458004636 active site 282458004637 substrate binding site [chemical binding]; other site 282458004638 Pfam match to entry PF01259 SAICAR_synt, SAICAR synthetase, score 310.30, E-value 2.2e-89 282458004639 PS01058 SAICAR synthetase signature 2. 282458004640 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 282458004641 Pfam match to entry PF02700 UPF0062, Uncharacterized ACR, YexA/UPF0062 family, score 67.60, E-value 2.6e-16 282458004642 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 282458004643 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 282458004644 putative active site [active] 282458004645 catalytic triad [active] 282458004646 PS00442 Glutamine amidotransferases class-I active site. 282458004647 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 282458004648 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 282458004649 dimerization interface [polypeptide binding]; other site 282458004650 ATP binding site [chemical binding]; other site 282458004651 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 282458004652 dimerization interface [polypeptide binding]; other site 282458004653 ATP binding site [chemical binding]; other site 282458004654 Pfam match to entry PF00586 AIRS, AIR synthase related protein, N-terminal domain, score 168.70, E-value 9.9e-47 282458004655 Pfam match to entry PF02769 AIRS_C, AIR synthase related protein, C-terminal domain, score 137.00, E-value 1.5e-37 282458004656 Pfam match to entry PF00586 AIRS, AIR synthase related protein, N-terminal domain, score 125.00, E-value 1.4e-33 282458004657 amidophosphoribosyltransferase; Provisional; Region: PRK07272 282458004658 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 282458004659 active site 282458004660 tetramer interface [polypeptide binding]; other site 282458004661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282458004662 active site 282458004663 PS00443 Glutamine amidotransferases class-II active site. 282458004664 Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II, score 200.00, E-value 1.3e-67 282458004665 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 54.30, E-value 2.6e-12 282458004666 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 282458004667 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 282458004668 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 282458004669 dimerization interface [polypeptide binding]; other site 282458004670 putative ATP binding site [chemical binding]; other site 282458004671 Pfam match to entry PF00586 AIRS, AIR synthase related protein, N-terminal domain, score 227.40, E-value 2.1e-64 282458004672 Pfam match to entry PF02769 AIRS_C, AIR synthase related protein, C-terminal domain, score 182.30, E-value 7.6e-51 282458004673 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 282458004674 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 282458004675 active site 282458004676 substrate binding site [chemical binding]; other site 282458004677 cosubstrate binding site; other site 282458004678 catalytic site [active] 282458004679 Pfam match to entry PF00551 formyl_transf, Formyl transferase, score 217.20, E-value 1.9e-61 282458004680 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 282458004681 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 282458004682 purine monophosphate binding site [chemical binding]; other site 282458004683 dimer interface [polypeptide binding]; other site 282458004684 putative catalytic residues [active] 282458004685 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 282458004686 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 282458004687 Pfam match to entry PF02142 MGS, MGS-like domain, score 185.90, E-value 6.6e-52 282458004688 Pfam match to entry PF01808 AICARFT_IMPCHas, AICARFT/IMPCHase bienzyme, score 404.90, E-value 7.7e-118 282458004689 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 282458004690 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 282458004691 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 282458004692 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 282458004693 Pfam match to entry PF02844 GARS_N, Phosphoribosylglycinamide synthetase, N domain, score 155.30, E-value 1.1e-42 282458004694 Pfam match to entry PF02842 GARS_B, Phosphoribosylglycinamide synthetase, B domain, score 98.80, E-value 1.1e-25 282458004695 Pfam match to entry PF01071 GARS, Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain, score 222.30, E-value 7e-63 282458004696 PS00184 Phosphoribosylglycinamide synthetase signature. 282458004697 Pfam match to entry PF02843 GARS_C, Phosphoribosylglycinamide synthetase, C domain, score 93.00, E-value 6.1e-24 282458004698 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 282458004699 6 probable transmembrane helices predicted for SAR1049 by TMHMM2.0 at aa 20-39, 44-61, 66-88, 119-141, 153-172 and 239-261 282458004700 Pfam match to entry PF02361 CbiQ, Cobalt transport protein, score 61.20, E-value 2.3e-14 282458004701 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 282458004702 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 282458004703 Walker A/P-loop; other site 282458004704 ATP binding site [chemical binding]; other site 282458004705 Q-loop/lid; other site 282458004706 ABC transporter signature motif; other site 282458004707 Walker B; other site 282458004708 D-loop; other site 282458004709 H-loop/switch region; other site 282458004710 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 282458004711 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 282458004712 Walker A/P-loop; other site 282458004713 ATP binding site [chemical binding]; other site 282458004714 Q-loop/lid; other site 282458004715 ABC transporter signature motif; other site 282458004716 Walker B; other site 282458004717 D-loop; other site 282458004718 H-loop/switch region; other site 282458004719 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 135.60, E-value 9e-37 282458004720 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004721 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004722 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 118.60, E-value 1.2e-31 282458004723 PS00211 ABC transporters family signature. 282458004724 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004725 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 282458004726 Signal peptide predicted for SAR1051 by SignalP 2.0 HMM (Signal peptide probabilty 0.747) with cleavage site probability 0.540 between residues 36 and 37; signal peptide 282458004727 5 probable transmembrane helices predicted for SAR1051 by TMHMM2.0 at aa 10-31, 47-69, 84-106, 113-135 and 145-167 282458004728 10 probable transmembrane helices predicted for SAR1053 by TMHMM2.0 at aa 12-34, 69-91, 104-123, 128-147, 160-182, 192-214, 309-326, 346-368, 375-397 and 401-423 282458004729 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 282458004730 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 282458004731 putative RNA binding site [nucleotide binding]; other site 282458004732 Methyltransferase domain; Region: Methyltransf_26; pfam13659 282458004733 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 282458004734 dimerization domain swap beta strand [polypeptide binding]; other site 282458004735 regulatory protein interface [polypeptide binding]; other site 282458004736 active site 282458004737 regulatory phosphorylation site [posttranslational modification]; other site 282458004738 Pfam match to entry PF00381 PTS-HPr, PTS HPr component phosphorylation sites, score 191.10, E-value 4.5e-54 282458004739 PS00369 PTS HPR component histidine phosphorylation site signature. 282458004740 PS00589 PTS HPR component serine phosphorylation site signature. 282458004741 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 282458004742 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 282458004743 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 282458004744 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 282458004745 Pfam match to entry PF00391 PEP-utilizers, PEP-utilizing enzyme, mobile domain, score 143.90, E-value 2.9e-39 282458004746 PS00370 PEP-utilizing enzymes phosphorylation site signature. 282458004747 Pfam match to entry PF02896 PEP-utilizers_C, PEP-utilizing enzyme, TIM barrel domain, score 648.50, E-value 3.7e-191 282458004748 PS00742 PEP-utilizing enzymes signature 2. 282458004749 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 282458004750 catalytic residues [active] 282458004751 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 282458004752 Pfam match to entry PF01654 Bac_Ubq_Cox, Bacterial Cytochrome Ubiquinol Oxidase, score 378.10, E-value 2.5e-112 282458004753 9 probable transmembrane helices predicted for SAR1059 by TMHMM2.0 at aa 15-37, 58-80, 90-112, 124-146, 182-204, 225-242, 322-344, 357-379 and 405-427 282458004754 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 282458004755 9 probable transmembrane helices predicted for SAR1060 by TMHMM2.0 at aa 10-32, 52-74, 84-103, 116-138, 158-180, 201-223, 233-255, 260-279 and 306-328 282458004756 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 282458004757 TrkA-N domain; Region: TrkA_N; pfam02254 282458004758 TrkA-C domain; Region: TrkA_C; pfam02080 282458004759 Pfam match to entry PF02254 KTN, KTN NAD-binding domain, score 163.60, E-value 3.4e-45 282458004760 Pfam match to entry PF02080 TrkA, Potassium channel, score 79.10, E-value 9.3e-20 282458004761 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 282458004762 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 282458004763 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 282458004764 Pfam match to entry PF02147 UPF0036, Uncharacterized protein family UPF0036, score 583.40, E-value 1.4e-171 282458004765 PS00018 EF-hand calcium-binding domain. 282458004766 PS01292 Uncharacterized protein family UPF0036 signature. 282458004767 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 121.40, E-value 1.7e-32 282458004768 PS00136 Serine proteases, subtilase, aspartic acid active site. 282458004769 hypothetical protein; Provisional; Region: PRK13667 282458004770 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 282458004771 active site 282458004772 catalytic residues [active] 282458004773 metal binding site [ion binding]; metal-binding site 282458004774 Pfam match to entry PF01327 Pep_deformylase, Polypeptide deformylase, score 276.70, E-value 3.1e-79 282458004775 Signal peptide predicted for SAR1066 by SignalP 2.0 HMM (Signal peptide probabilty 0.955) with cleavage site probability 0.374 between residues 25 and 26; signal peptide 282458004776 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 282458004777 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458004778 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 282458004779 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 282458004780 TPP-binding site [chemical binding]; other site 282458004781 tetramer interface [polypeptide binding]; other site 282458004782 heterodimer interface [polypeptide binding]; other site 282458004783 phosphorylation loop region [posttranslational modification] 282458004784 Pfam match to entry PF00676 E1_dehydrog, Dehydrogenase E1 component, score 486.70, E-value 1.9e-142 282458004785 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 282458004786 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 282458004787 alpha subunit interface [polypeptide binding]; other site 282458004788 TPP binding site [chemical binding]; other site 282458004789 heterodimer interface [polypeptide binding]; other site 282458004790 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 282458004791 Pfam match to entry PF02779 transket_pyr, Transketolase, central domain, score 199.80, E-value 4.3e-56 282458004792 Pfam match to entry PF02780 transketolase_C, Transketolase, C-terminal domain, score 188.70, E-value 9.1e-53 282458004793 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 282458004794 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 282458004795 E3 interaction surface; other site 282458004796 lipoyl attachment site [posttranslational modification]; other site 282458004797 e3 binding domain; Region: E3_binding; pfam02817 282458004798 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 282458004799 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme, score 117.60, E-value 2.4e-31 282458004800 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 282458004801 Pfam match to entry PF02817 e3_binding, e3 binding domain, score 76.80, E-value 4.5e-19 282458004802 Pfam match to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain), score 466.20, E-value 2.6e-136 282458004803 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 282458004804 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 282458004805 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282458004806 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 282458004807 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 345.50, E-value 5.6e-100 282458004808 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 282458004809 Pfam match to entry PF02852 pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 185.30, E-value 9.6e-52 282458004810 hypothetical protein; Provisional; Region: PRK04387 282458004811 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 282458004812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282458004813 non-specific DNA binding site [nucleotide binding]; other site 282458004814 salt bridge; other site 282458004815 sequence-specific DNA binding site [nucleotide binding]; other site 282458004816 Cupin domain; Region: Cupin_2; pfam07883 282458004817 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 65.10, E-value 1.5e-15 282458004818 Predicted helix-turn-helix motif with score 1972 (+5.90 SD) at aa 16-37, sequence LTQEELAERTDLSKGYISQIES 282458004819 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 282458004820 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282458004821 Walker A/P-loop; other site 282458004822 ATP binding site [chemical binding]; other site 282458004823 Q-loop/lid; other site 282458004824 ABC transporter signature motif; other site 282458004825 Walker B; other site 282458004826 D-loop; other site 282458004827 H-loop/switch region; other site 282458004828 TOBE domain; Region: TOBE_2; pfam08402 282458004829 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 210.60, E-value 2.3e-59 282458004830 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004831 PS00211 ABC transporters family signature. 282458004832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458004833 putative PBP binding loops; other site 282458004834 dimer interface [polypeptide binding]; other site 282458004835 ABC-ATPase subunit interface; other site 282458004836 6 probable transmembrane helices predicted for SAR1074 by TMHMM2.0 at aa 7-29, 60-82, 89-111, 131-153, 193-215 and 235-257 282458004837 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 42.40, E-value 9.9e-09 282458004838 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282458004839 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 282458004840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458004841 dimer interface [polypeptide binding]; other site 282458004842 conserved gate region; other site 282458004843 putative PBP binding loops; other site 282458004844 ABC-ATPase subunit interface; other site 282458004845 6 probable transmembrane helices predicted for SAR1075 by TMHMM2.0 at aa 7-29, 62-84, 97-119, 129-151, 175-197 and 236-258 282458004846 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 34.10, E-value 3.1e-06 282458004847 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 282458004848 Signal peptide predicted for SAR1076 by SignalP 2.0 HMM (Signal peptide probabilty 0.945) with cleavage site probability 0.584 between residues 31 and 32; signal peptide 282458004849 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 282458004850 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 282458004851 1 probable transmembrane helix predicted for SAR1076 by TMHMM2.0 at aa 7-25 282458004852 Pfam match to entry PF01547 SBP_bacterial_1, Bacterial extracellular solute-binding protein, score 50.70, E-value 3.2e-11 282458004853 Signal peptide predicted for SAR1077 by SignalP 2.0 HMM (Signal peptide probabilty 0.921) with cleavage site probability 0.603 between residues 45 and 46; signal peptide 282458004854 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 282458004855 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 282458004856 3 probable transmembrane helices predicted for SAR1077 by TMHMM2.0 at aa 20-42, 84-106 and 113-147 282458004857 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 282458004858 3 probable transmembrane helices predicted for SAR1078 by TMHMM2.0 at aa 7-29, 61-83 and 90-121 282458004859 manganese transport protein MntH; Reviewed; Region: PRK00701 282458004860 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 282458004861 10 probable transmembrane helices predicted for SAR1079 by TMHMM2.0 at aa 33-55, 59-81, 102-124, 139-161, 168-190, 210-232, 263-285, 305-327, 384-406 and 421-443 282458004862 Pfam match to entry PF01566 Nramp, Natural resistance-associated macrophage protein, score 470.70, E-value 1.2e-137 282458004863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 282458004864 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 282458004865 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 282458004866 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 282458004867 active site 282458004868 Pfam match to entry PF00459 inositol_P, Inositol monophosphatase, score 214.90, E-value 1.2e-60 282458004869 PS00629 Inositol monophosphatase signature 1. 282458004870 Signal peptide predicted for SAR1082 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.840 between residues 30 and 31; signal peptide 282458004871 2 probable transmembrane helices predicted for SAR1082 by TMHMM2.0 at aa 9-31 and 35-52 282458004872 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 282458004873 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 282458004874 G1 box; other site 282458004875 putative GEF interaction site [polypeptide binding]; other site 282458004876 GTP/Mg2+ binding site [chemical binding]; other site 282458004877 Switch I region; other site 282458004878 G2 box; other site 282458004879 G3 box; other site 282458004880 Switch II region; other site 282458004881 G4 box; other site 282458004882 G5 box; other site 282458004883 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 282458004884 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 282458004885 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family, score 354.60, E-value 1.1e-102 282458004886 PS00017 ATP/GTP-binding site motif A (P-loop). 282458004887 PS00301 GTP-binding elongation factors signature. 282458004888 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 282458004889 hypothetical protein; Provisional; Region: PRK13666 282458004890 Signal peptide predicted for SAR1087 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.860 between residues 45 and 46; signal peptide 282458004891 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 282458004892 10 probable transmembrane helices predicted for SAR1087 by TMHMM2.0 at aa 20-42, 66-88, 93-111, 126-148, 160-177, 181-203, 208-230, 288-313, 326-348 and 363-385 282458004893 Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein, score 287.80, E-value 1.3e-82 282458004894 pyruvate carboxylase; Reviewed; Region: PRK12999 282458004895 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 282458004896 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 282458004897 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 282458004898 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 282458004899 active site 282458004900 catalytic residues [active] 282458004901 metal binding site [ion binding]; metal-binding site 282458004902 homodimer binding site [polypeptide binding]; other site 282458004903 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 282458004904 carboxyltransferase (CT) interaction site; other site 282458004905 biotinylation site [posttranslational modification]; other site 282458004906 Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase L chain, N-terminal domain, score 131.70, E-value 1.3e-35 282458004907 Pfam match to entry PF02786 CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain, score 356.20, E-value 3.5e-103 282458004908 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 282458004909 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 282458004910 Pfam match to entry PF02785 Biotin_carb_C, Biotin carboxylase C-terminal domain, score 201.60, E-value 1.3e-56 282458004911 Pfam match to entry PF00682 HMGL-like, HMGL-like, score 120.90, E-value 2.5e-32 282458004912 Pfam match to entry PF02436 PYC_OADA, Conserved carboxylase domain, score 330.80, E-value 1.5e-95 282458004913 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme, score 90.20, E-value 4.2e-23 282458004914 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 282458004915 Signal peptide predicted for SAR1089 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.739 between residues 34 and 35; signal peptide 282458004916 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 282458004917 Pfam match to entry PF02628 COX15-CtaA, Cytochrome oxidase assembly protein, score 141.10, E-value 1.9e-38 282458004918 8 probable transmembrane helices predicted for SAR1089 by TMHMM2.0 at aa 7-29, 65-87, 94-116, 121-143, 164-181, 211-233, 245-267 and 271-293 282458004919 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 282458004920 UbiA prenyltransferase family; Region: UbiA; pfam01040 282458004921 8 probable transmembrane helices predicted for SAR1090 by TMHMM2.0 at aa 22-44, 54-76, 104-123, 127-144, 149-171, 175-197, 227-260 and 280-302 282458004922 Pfam match to entry PF01040 UbiA, UbiA prenyltransferase, score 239.30, E-value 5.4e-68 282458004923 Predicted membrane protein [Function unknown]; Region: COG2322 282458004924 4 probable transmembrane helices predicted for SAR1091 by TMHMM2.0 at aa 5-27, 39-61, 76-98 and 118-140 282458004925 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 282458004926 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 282458004927 1 probable transmembrane helix predicted for SAR1092 by TMHMM2.0 at aa 5-24 282458004928 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 282458004929 Signal peptide predicted for SAR1094 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.587 between residues 30 and 31; signal peptide 282458004930 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 282458004931 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 282458004932 putative active site [active] 282458004933 catalytic site [active] 282458004934 putative metal binding site [ion binding]; other site 282458004935 1 probable transmembrane helix predicted for SAR1094 by TMHMM2.0 at aa 7-25 282458004936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 282458004937 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 282458004938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458004939 S-adenosylmethionine binding site [chemical binding]; other site 282458004940 PS00092 N-6 Adenine-specific DNA methylases signature. 282458004941 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 282458004942 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 282458004943 active site 282458004944 (T/H)XGH motif; other site 282458004945 Pfam match to entry PF01467 Cytidylyltransf, Cytidylyltransferase, score 129.00, E-value 8.4e-35 282458004946 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 282458004947 hypothetical protein; Provisional; Region: PRK13670 282458004948 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 282458004949 Pfam match to entry PF02620 DUF177, Uncharacterized ACR, COG1399, score -19.30, E-value 0.0076 282458004950 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 282458004951 Pfam match to entry PF01783 Ribosomal_L32p, Ribosomal L32p protein family, score 54.10, E-value 3e-12 282458004952 Signal peptide predicted for SAR1102 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.938 between residues 40 and 41; signal peptide 282458004953 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282458004954 heme uptake protein IsdB; Region: IsdB; TIGR03657 282458004955 NEAr Transporter domain; Region: NEAT; smart00725 282458004956 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 282458004957 heme-binding site [chemical binding]; other site 282458004958 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 282458004959 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 21.90, E-value 0.015 282458004960 1 probable transmembrane helix predicted for SAR1102 by TMHMM2.0 at aa 629-646 282458004961 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282458004962 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 282458004963 Signal peptide predicted for SAR1103 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.659 between residues 46 and 47; signal peptide 282458004964 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 282458004965 heme-binding site [chemical binding]; other site 282458004966 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 23.70, E-value 0.0045 282458004967 1 probable transmembrane helix predicted for SAR1103 by TMHMM2.0 at aa 329-348 282458004968 heme uptake protein IsdC; Region: IsdC; TIGR03656 282458004969 Signal peptide predicted for SAR1104 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.990 between residues 28 and 29; signal peptide 282458004970 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 282458004971 heme-binding site [chemical binding]; other site 282458004972 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 282458004973 2 probable transmembrane helices predicted for SAR1104 by TMHMM2.0 at aa 7-29 and 196-218 282458004974 Signal peptide predicted for SAR1105 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.978 between residues 32 and 33; signal peptide 282458004975 2 probable transmembrane helices predicted for SAR1105 by TMHMM2.0 at aa 13-32 and 329-351 282458004976 Signal peptide predicted for SAR1106 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.699 between residues 27 and 28; signal peptide 282458004977 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 282458004978 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 282458004979 intersubunit interface [polypeptide binding]; other site 282458004980 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458004981 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 109.60, E-value 5.9e-29 282458004982 Signal peptide predicted for SAR1107 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.393 between residues 29 and 30; signal peptide 282458004983 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 282458004984 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282458004985 ABC-ATPase subunit interface; other site 282458004986 dimer interface [polypeptide binding]; other site 282458004987 putative PBP binding regions; other site 282458004988 8 probable transmembrane helices predicted for SAR1107 by TMHMM2.0 at aa 9-31, 60-82, 112-134, 138-160, 180-202, 230-252, 264-286 and 296-315 282458004989 Pfam match to entry PF01032 FecCD_family, FecCD transport family, score 240.60, E-value 2.2e-68 282458004990 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 282458004991 active site 282458004992 catalytic site [active] 282458004993 1 probable transmembrane helix predicted for SAR1108 by TMHMM2.0 at aa 7-29 282458004994 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 282458004995 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 282458004996 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 282458004997 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 282458004998 Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase, score 105.80, E-value 8.3e-28 282458004999 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 282458005000 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 282458005001 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 282458005002 dimer interface [polypeptide binding]; other site 282458005003 motif 1; other site 282458005004 active site 282458005005 motif 2; other site 282458005006 motif 3; other site 282458005007 Pfam match to entry PF02912 Phe_tRNA-synt_N, Aminoacyl tRNA synthetase class II, N-terminal domain, score 81.50, E-value 1.8e-20 282458005008 Pfam match to entry PF01409 tRNA-synt_2d, tRNA synthetases class II (F), score 408.50, E-value 6.5e-119 282458005009 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 282458005010 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 282458005011 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 282458005012 putative tRNA-binding site [nucleotide binding]; other site 282458005013 B3/4 domain; Region: B3_4; pfam03483 282458005014 tRNA synthetase B5 domain; Region: B5; smart00874 282458005015 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 282458005016 dimer interface [polypeptide binding]; other site 282458005017 motif 1; other site 282458005018 motif 3; other site 282458005019 motif 2; other site 282458005020 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 282458005021 Pfam match to entry PF01588 tRNA_bind, tRNA binding domain, score 51.30, E-value 2.2e-11 282458005022 Pfam match to entry PF01588 tRNA_bind, tRNA binding domain, score 22.50, E-value 0.0015 282458005023 ribonuclease HIII; Provisional; Region: PRK00996 282458005024 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 282458005025 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 282458005026 RNA/DNA hybrid binding site [nucleotide binding]; other site 282458005027 active site 282458005028 Pfam match to entry PF01351 RNase_HII, Ribonuclease HII, score 161.90, E-value 1.1e-44 282458005029 Cell division protein ZapA; Region: ZapA; cl01146 282458005030 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 282458005031 Colicin V production protein; Region: Colicin_V; pfam02674 282458005032 4 probable transmembrane helices predicted for SAR1115 by TMHMM2.0 at aa 5-24, 80-102, 117-139 and 152-171 282458005033 hypothetical protein; Provisional; Region: PRK08609 282458005034 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 282458005035 active site 282458005036 primer binding site [nucleotide binding]; other site 282458005037 NTP binding site [chemical binding]; other site 282458005038 metal binding triad [ion binding]; metal-binding site 282458005039 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 282458005040 active site 282458005041 Pfam match to entry PF00966 DNA_polymeraseX, DNA polymerase X family, score 93.30, E-value 4.8e-24 282458005042 Pfam match to entry PF02231 PHP_N, PHP domain N-terminal region, score 72.50, E-value 8.9e-18 282458005043 Pfam match to entry PF02811 PHP_C, PHP domain C-terminal region, score 48.80, E-value 1.2e-10 282458005044 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 282458005045 MutS domain III; Region: MutS_III; pfam05192 282458005046 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 282458005047 Walker A/P-loop; other site 282458005048 ATP binding site [chemical binding]; other site 282458005049 Q-loop/lid; other site 282458005050 ABC transporter signature motif; other site 282458005051 Walker B; other site 282458005052 D-loop; other site 282458005053 H-loop/switch region; other site 282458005054 Smr domain; Region: Smr; pfam01713 282458005055 PS00591 Glycosyl hydrolases family 10 active site. 282458005056 Pfam match to entry PF00488 MutS_C, DNA mismatch repair proteins, mutS family, score 26.50, E-value 2.3e-06 282458005057 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005058 Pfam match to entry PF00488 MutS_C, DNA mismatch repair proteins, mutS family, score 53.10, E-value 8e-14 282458005059 Pfam match to entry PF01713 Smr, Smr domain, score 102.10, E-value 1.1e-26 282458005060 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 282458005061 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 282458005062 catalytic residues [active] 282458005063 Pfam match to entry PF00085 thiored, Thioredoxin, score 143.10, E-value 7.3e-42 282458005064 PS00194 Thioredoxin family active site. 282458005065 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 282458005066 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 282458005067 GIY-YIG motif/motif A; other site 282458005068 active site 282458005069 catalytic site [active] 282458005070 putative DNA binding site [nucleotide binding]; other site 282458005071 metal binding site [ion binding]; metal-binding site 282458005072 UvrB/uvrC motif; Region: UVR; pfam02151 282458005073 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 282458005074 Pfam match to entry PF01541 Exci_endo_N, Endo/excinuclease amino terminal domain, score 142.00, E-value 1.1e-38 282458005075 Pfam match to entry PF02151 UVR, UvrB/uvrC motif, score 44.90, E-value 1.9e-09 282458005076 Signal peptide predicted for SAR1120 by SignalP 2.0 HMM (Signal peptide probabilty 0.875) with cleavage site probability 0.428 between residues 42 and 43; signal peptide 282458005077 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 282458005078 putative Iron-sulfur protein interface [polypeptide binding]; other site 282458005079 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 282458005080 proximal heme binding site [chemical binding]; other site 282458005081 distal heme binding site [chemical binding]; other site 282458005082 putative dimer interface [polypeptide binding]; other site 282458005083 5 probable transmembrane helices predicted for SAR1120 by TMHMM2.0 at aa 13-32, 52-74, 95-117, 145-167 and 180-202 282458005084 Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochrome b subunit, score -44.20, E-value 0.98 282458005085 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 282458005086 Signal peptide predicted for SAR1121 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.846 between residues 22 and 23; signal peptide 282458005087 L-aspartate oxidase; Provisional; Region: PRK06175 282458005088 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 282458005089 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 282458005090 Pfam match to entry PF00890 FAD_binding_2, FAD binding domain, score 475.70, E-value 3.8e-139 282458005091 Pfam match to entry PF02910 succ_DH_flav_C, Fumarate reductase/succinate dehydrogenase flavoprotein C-terminal domain, score 183.10, E-value 4.6e-51 282458005092 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 282458005093 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 282458005094 Pfam match to entry PF00037 fer4, 4Fe-4S binding domain, score 13.90, E-value 0.018 282458005095 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 282458005096 glutamate racemase; Provisional; Region: PRK00865 282458005097 Pfam match to entry PF01177 Asp_Glu_race, Asp/Glu/Hydontoin racemase, score 417.20, E-value 1.5e-121 282458005098 PS00923 Aspartate and glutamate racemases signature 1. 282458005099 PS00924 Aspartate and glutamate racemases signature 2. 282458005100 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 282458005101 active site 282458005102 dimerization interface [polypeptide binding]; other site 282458005103 Pfam match to entry PF01725 Ham1p_like, Ham1 family, score 246.60, E-value 3.5e-70 282458005104 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 282458005105 active site 282458005106 metal binding site [ion binding]; metal-binding site 282458005107 homotetramer interface [polypeptide binding]; other site 282458005108 Pfam match to entry PF01143 UPF0025, Uncharacterized phosphoesterase UPF0025, score 26.30, E-value 5.9e-09 282458005109 Signal peptide predicted for SAR1127 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 29 and 30; signal peptide 282458005110 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 282458005111 Similar to Staphylococcus aureus hypothetical protein SAV1156 or SA1001 SWALL:Q99UV1 (EMBL:AP003361) (133 aa) fasta scores: E(): 2.3e-35, 78.94% id in 133 aa, and to Staphylococcus aureus hypothetical protein MW1038 SWALL:Q8NX51 (EMBL:AP004825) (132 aa) fasta scores: E(): 2.3e-31, 74.24% id in 132 aa. CDS contains a frameshift after codon 2. Frameshift occur at a poly A heptamer;hypothetical protein (pseudogene) 282458005112 Signal peptide predicted for SAR1128 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.768 between residues 28 and 29 282458005113 Signal peptide predicted for SAR1129 by SignalP 2.0 HMM (Signal peptide probabilty 0.798) with cleavage site probability 0.290 between residues 21 and 22; signal peptide 282458005114 5 probable transmembrane helices predicted for SAR1129 by TMHMM2.0 at aa 2-20, 35-57, 64-86, 101-120 and 141-160 282458005115 Signal peptide predicted for SAR1130 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.951 between residues 29 and 30; signal peptide 282458005116 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 282458005117 1 probable transmembrane helix predicted for SAR1130 by TMHMM2.0 at aa 5-27 282458005118 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 282458005119 Signal peptide predicted for SAR1131 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.881 between residues 31 and 32; signal peptide 282458005120 Signal peptide predicted for SAR1133 by SignalP 2.0 HMM (Signal peptide probabilty 0.662) with cleavage site probability 0.659 between residues 53 and 54; signal peptide 282458005121 1 probable transmembrane helix predicted for SAR1133 by TMHMM2.0 at aa 38-60 282458005122 PS00190 Cytochrome c family heme-binding site signature. 282458005123 3 probable transmembrane helices predicted for SAR1133a by TMHMM2.0 at aa 2-24, 29-51 and 58-80 282458005124 Similar to Staphylococcus aureus alpha-hemolysin (alpha-toxin) precursor Hla SW:HLA_STAAU (P09616) (319 aa) fasta scores: E(): 1e-119, 98.119% id in 319 aa, and to the N-terminus of Bacillus cereus hemolysin II Hly-II TR:O05387 (EMBL:U94743) (412 aa) fasta scores: E(): 2.1e-28, 31.746% id in 315 aa. Contains a nonsense mutation (amber) after codon 112;alpha-hemolysin precursor (pseudogene) 282458005125 Pfam match to entry PF01117 Aerolysin, Aerolysin/Leukocidin family toxin, score 213.30, E-value 3.6e-60 282458005126 PS00274 Aerolysin type toxins signature. 282458005127 Signal peptide predicted for SAR1136 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.937 between residues 26 and 27 282458005128 1 probable transmembrane helix predicted for SAR1136a by TMHMM2.0 at aa 5-36 282458005129 Insertion sequence IS1272 282458005130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 282458005131 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458005132 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 282458005133 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458005134 superantigen-like protein; Reviewed; Region: PRK13350 282458005135 Signal peptide predicted for SAR1139 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.551 between residues 38 and 39; signal peptide 282458005136 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458005137 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458005138 superantigen-like protein; Reviewed; Region: PRK13349 282458005139 Signal peptide predicted for SAR1140 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.409 between residues 36 and 37; signal peptide 282458005140 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458005141 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -12.30, E-value 0.042 282458005142 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458005143 superantigen-like protein; Reviewed; Region: PRK13043 282458005144 Signal peptide predicted for SAR1141 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.471 between residues 33 and 34; signal peptide 282458005145 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458005146 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -10.40, E-value 0.03 282458005147 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458005148 ornithine carbamoyltransferase; Provisional; Region: PRK04284 282458005149 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 282458005150 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 282458005151 Pfam match to entry PF02729 OTCace_N, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain, score 234.70, E-value 1.3e-66 282458005152 PS00097 Aspartate and ornithine carbamoyltransferases signature. 282458005153 Pfam match to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain, score 276.10, E-value 1.1e-80 282458005154 carbamate kinase; Reviewed; Region: PRK12686 282458005155 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 282458005156 putative substrate binding site [chemical binding]; other site 282458005157 nucleotide binding site [chemical binding]; other site 282458005158 nucleotide binding site [chemical binding]; other site 282458005159 homodimer interface [polypeptide binding]; other site 282458005160 Pfam match to entry PF00696 aakinase, Amino acid kinase, score 291.30, E-value 1.2e-83 282458005161 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005162 Signal peptide predicted for SAR1144 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.687 between residues 43 and 44; signal peptide 282458005163 Predicted membrane protein [Function unknown]; Region: COG1288 282458005164 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 282458005165 13 probable transmembrane helices predicted for SAR1144 by TMHMM2.0 at aa 21-43, 127-149, 162-184, 189-211, 213-235, 245-267, 308-325, 329-351, 364-386, 406-428, 435-457, 462-481 and 494-516 282458005166 PS00012 Phosphopantetheine attachment site. 282458005167 2 probable transmembrane helices predicted for SAR1146 by TMHMM2.0 at aa 10-32 and 39-61 282458005168 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 282458005169 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 282458005170 gating phenylalanine in ion channel; other site 282458005171 10 probable transmembrane helices predicted for SAR1147 by TMHMM2.0 at aa 7-24, 29-51, 64-86, 96-118, 130-149, 153-175, 187-209, 214-233, 246-268 and 278-300 282458005172 Predicted helix-turn-helix motif with score 1183 (+3.22 SD) at aa 22-43, sequence LSSLHISKQTGVPQSTIHRMRK 282458005173 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 282458005174 PS00572 Glycosyl hydrolases family 1 active site. 282458005175 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 282458005176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458005177 motif II; other site 282458005178 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 66.90, E-value 4.1e-16 282458005179 hypothetical protein; Provisional; Region: PRK13688 282458005180 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 282458005181 Coenzyme A binding pocket [chemical binding]; other site 282458005182 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 23.80, E-value 0.0042 282458005183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 282458005184 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 282458005185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 282458005186 MraZ protein; Region: MraZ; pfam02381 282458005187 MraZ protein; Region: MraZ; pfam02381 282458005188 Pfam match to entry PF02381 UPF0040, Domain of unknown function UPF0040 family, score 116.60, E-value 4.8e-31 282458005189 Pfam match to entry PF02381 UPF0040, Domain of unknown function UPF0040 family, score 128.20, E-value 1.5e-34 282458005190 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 282458005191 MraW methylase family; Region: Methyltransf_5; pfam01795 282458005192 Pfam match to entry PF01795 Methyltransf_5, MraW methylase, score 706.30, E-value 1.9e-211 282458005193 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 282458005194 1 probable transmembrane helix predicted for SAR1156 by TMHMM2.0 at aa 46-65 282458005195 Signal peptide predicted for SAR1157 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.423 between residues 42 and 43; signal peptide 282458005196 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 282458005197 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 282458005198 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 282458005199 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 282458005200 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 282458005201 1 probable transmembrane helix predicted for SAR1157 by TMHMM2.0 at aa 13-35 282458005202 Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain, score 464.10, E-value 1.1e-135 282458005203 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005204 Pfam match to entry PF02968 PBP_C, Penicillin binding protein transpeptidase domain, score 122.50, E-value 8e-33 282458005205 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 282458005206 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 282458005207 Mg++ binding site [ion binding]; other site 282458005208 putative catalytic motif [active] 282458005209 putative substrate binding site [chemical binding]; other site 282458005210 10 probable transmembrane helices predicted for SAR1158 by TMHMM2.0 at aa 2-24, 47-69, 76-98, 113-135, 142-164, 174-196, 201-220, 225-244, 251-273 and 301-320 282458005211 Pfam match to entry PF00953 Glycos_transf_4, Glycosyl transferase, score 290.00, E-value 3e-83 282458005212 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 282458005213 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 282458005214 NAD binding site [chemical binding]; other site 282458005215 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 282458005216 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 282458005217 Pfam match to entry PF01225 Mur_ligase, Mur ligase, catalytic domain, score 266.00, E-value 1.1e-77 282458005218 Pfam match to entry PF02875 Mur_ligase_C, Mur ligase, glutamate ligase domain, score 69.60, E-value 6.8e-17 282458005219 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 282458005220 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 282458005221 Cell division protein FtsQ; Region: FtsQ; pfam03799 282458005222 1 probable transmembrane helix predicted for SAR1160 by TMHMM2.0 at aa 172-194 282458005223 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 282458005224 Cell division protein FtsA; Region: FtsA; smart00842 282458005225 Cell division protein FtsA; Region: FtsA; pfam14450 282458005226 Pfam match to entry PF02491 FtsA, Cell division protein FtsA, score 655.60, E-value 2.6e-193 282458005227 cell division protein FtsZ; Validated; Region: PRK09330 282458005228 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 282458005229 nucleotide binding site [chemical binding]; other site 282458005230 SulA interaction site; other site 282458005231 PS01134 FtsZ protein signature 1. 282458005232 Pfam match to entry PF00091 tubulin, Tubulin/FtsZ family, score 80.00, E-value 5e-20 282458005233 PS01135 FtsZ protein signature 2. 282458005234 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 282458005235 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 282458005236 Pfam match to entry PF02578 DUF152, Uncharacterized ACR, YfiH family COG1496, score 110.90, E-value 2.5e-29 282458005237 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 282458005238 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 282458005239 catalytic residue [active] 282458005240 Pfam match to entry PF01168 UPF0001, Uncharacterized protein family UPF0001, score 124.30, E-value 2.2e-33 282458005241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 282458005242 YGGT family; Region: YGGT; pfam02325 282458005243 Pfam match to entry PF02325 YGGT, YGGT family, score 115.30, E-value 1.2e-30 282458005244 2 probable transmembrane helices predicted for SAR1166 by TMHMM2.0 at aa 12-34 and 59-81 282458005245 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 282458005246 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 282458005247 RNA binding surface [nucleotide binding]; other site 282458005248 Pfam match to entry PF01479 S4, S4 domain, score 40.00, E-value 5.2e-08 282458005249 DivIVA protein; Region: DivIVA; pfam05103 282458005250 DivIVA domain; Region: DivI1A_domain; TIGR03544 282458005251 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 282458005252 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 282458005253 HIGH motif; other site 282458005254 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 282458005255 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 282458005256 active site 282458005257 KMSKS motif; other site 282458005258 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 282458005259 tRNA binding surface [nucleotide binding]; other site 282458005260 anticodon binding site; other site 282458005261 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 282458005262 Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V), score 1224.40, E-value 0 282458005263 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282458005264 insertion sequence ISX 282458005265 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 282458005266 Helix-turn-helix domain; Region: HTH_38; pfam13936 282458005267 Integrase core domain; Region: rve; pfam00665 282458005268 Pfam match to entry PF00665 rve, Integrase core domain, score 119.70, E-value 2.1e-33 282458005269 PS01043 Transposases, IS30 family, signature. 282458005270 Predicted helix-turn-helix motif with score 1647 (+4.80 SD) at aa 22-43, sequence YSLRSIARKLKRSVSTISREIS 282458005271 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 282458005272 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 282458005273 active site 282458005274 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 18.30, E-value 0.00052 282458005275 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 282458005276 Signal peptide predicted for SAR1172 by SignalP 2.0 HMM (Signal peptide probabilty 0.871) with cleavage site probability 0.636 between residues 26 and 27; signal peptide 282458005277 lipoprotein signal peptidase; Provisional; Region: PRK14787 282458005278 4 probable transmembrane helices predicted for SAR1172 by TMHMM2.0 at aa 7-29, 64-83, 90-109 and 129-151 282458005279 Pfam match to entry PF01252 Peptidase_A8, Signal peptidase (SPase) II, score 278.90, E-value 6.7e-80 282458005280 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 282458005281 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 282458005282 RNA binding surface [nucleotide binding]; other site 282458005283 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 282458005284 active site 282458005285 Pfam match to entry PF01479 S4, S4 domain, score 45.30, E-value 1.4e-09 282458005286 Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase, score 264.60, E-value 1.3e-75 282458005287 PS01129 Rlu family of pseudouridine synthase signature. 282458005288 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 282458005289 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 282458005290 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 60.90, E-value 2.8e-14 282458005291 uracil transporter; Provisional; Region: PRK10720 282458005292 Pfam match to entry PF00860 xan_ur_permease, Xanthine/uracil permeases family, score 433.40, E-value 2e-126 282458005293 11 probable transmembrane helices predicted for SAR1175 by TMHMM2.0 at aa 47-69, 76-95, 100-122, 129-151, 166-183, 190-212, 240-262, 317-339, 349-371, 383-401 and 405-427 282458005294 PS01116 Xanthine/uracil permeases family signature. 282458005295 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 282458005296 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 282458005297 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 282458005298 Pfam match to entry PF02729 OTCace_N, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain, score 193.40, E-value 3.5e-54 282458005299 PS00097 Aspartate and ornithine carbamoyltransferases signature. 282458005300 Pfam match to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain, score 95.70, E-value 3.1e-27 282458005301 dihydroorotase; Validated; Region: pyrC; PRK09357 282458005302 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 282458005303 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 282458005304 active site 282458005305 Pfam match to entry PF00744 Dihydroorotase, Dihydroorotase-like, score 627.80, E-value 6e-185 282458005306 PS00482 Dihydroorotase signature 1. 282458005307 PS00483 Dihydroorotase signature 2. 282458005308 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 282458005309 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 282458005310 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 282458005311 catalytic site [active] 282458005312 subunit interface [polypeptide binding]; other site 282458005313 Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain, score 248.40, E-value 1e-74 282458005314 Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I, score 235.80, E-value 6.1e-67 282458005315 PS00442 Glutamine amidotransferases class-I active site. 282458005316 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 282458005317 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 282458005318 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 282458005319 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 282458005320 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 282458005321 ATP-grasp domain; Region: ATP-grasp_4; cl17255 282458005322 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 282458005323 IMP binding site; other site 282458005324 dimer interface [polypeptide binding]; other site 282458005325 interdomain contacts; other site 282458005326 partial ornithine binding site; other site 282458005327 Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase L chain, N-terminal domain, score 184.00, E-value 2.3e-51 282458005328 Pfam match to entry PF02786 CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain, score 441.60, E-value 6.9e-129 282458005329 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 282458005330 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 282458005331 Pfam match to entry PF02787 CPSase_L_D3, Carbamoyl-phosphate synthetase large chain, oligomerisation domain, score 227.30, E-value 2.3e-64 282458005332 Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase L chain, N-terminal domain, score 105.30, E-value 6.4e-28 282458005333 Pfam match to entry PF02786 CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain, score 128.20, E-value 1.5e-35 282458005334 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 282458005335 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 282458005336 Pfam match to entry PF02142 MGS, MGS-like domain, score 111.60, E-value 1.5e-29 282458005337 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 282458005338 active site 282458005339 dimer interface [polypeptide binding]; other site 282458005340 Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylase, score 170.10, E-value 2.5e-48 282458005341 PS00156 Orotidine 5'-phosphate decarboxylase active site. 282458005342 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282458005343 active site 282458005344 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 110.70, E-value 2.8e-29 282458005345 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 282458005346 PS00012 Phosphopantetheine attachment site. 282458005347 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 282458005348 dimer interface [polypeptide binding]; other site 282458005349 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 282458005350 Domain of unknown function (DUF814); Region: DUF814; pfam05670 282458005351 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 282458005352 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 282458005353 catalytic site [active] 282458005354 G-X2-G-X-G-K; other site 282458005355 PS00856 Guanylate kinase signature. 282458005356 Pfam match to entry PF00625 Guanylate_kin, Guanylate kinase, score 148.40, E-value 1.3e-40 282458005357 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 282458005358 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 282458005359 Flavoprotein; Region: Flavoprotein; pfam02441 282458005360 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 282458005361 Pfam match to entry PF02441 Flavoprotein, Flavoprotein, score 179.40, E-value 5.7e-50 282458005362 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 282458005363 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282458005364 ATP binding site [chemical binding]; other site 282458005365 putative Mg++ binding site [ion binding]; other site 282458005366 helicase superfamily c-terminal domain; Region: HELICc; smart00490 282458005367 nucleotide binding region [chemical binding]; other site 282458005368 ATP-binding site [chemical binding]; other site 282458005369 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005370 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 30.10, E-value 5.2e-05 282458005371 Signal peptide predicted for SAR1189 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.352 between residues 29 and 30; signal peptide 282458005372 1 probable transmembrane helix predicted for SAR1189 by TMHMM2.0 at aa 5-24 282458005373 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458005374 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 282458005375 2 probable transmembrane helices predicted for SAR1190 by TMHMM2.0 at aa 31-50 and 57-79 282458005376 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 282458005377 active site 282458005378 catalytic residues [active] 282458005379 metal binding site [ion binding]; metal-binding site 282458005380 Pfam match to entry PF01327 Pep_deformylase, Polypeptide deformylase, score 95.10, E-value 1.4e-24 282458005381 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 282458005382 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 282458005383 putative active site [active] 282458005384 substrate binding site [chemical binding]; other site 282458005385 putative cosubstrate binding site; other site 282458005386 catalytic site [active] 282458005387 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 282458005388 substrate binding site [chemical binding]; other site 282458005389 Pfam match to entry PF00551 formyl_transf, Formyl transferase, score 164.50, E-value 2.8e-46 282458005390 Pfam match to entry PF02911 formyl_trans_C, Formyl transferase, C-terminal domain, score 104.40, E-value 2.2e-27 282458005391 16S rRNA methyltransferase B; Provisional; Region: PRK14902 282458005392 NusB family; Region: NusB; pfam01029 282458005393 putative RNA binding site [nucleotide binding]; other site 282458005394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458005395 S-adenosylmethionine binding site [chemical binding]; other site 282458005396 Pfam match to entry PF01029 NusB, NusB family, score 115.80, E-value 8e-31 282458005397 Pfam match to entry PF01189 Nol1_Nop2_Sun, NOL1/NOP2/sun family, score 155.20, E-value 3.3e-44 282458005398 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 282458005399 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282458005400 FeS/SAM binding site; other site 282458005401 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 282458005402 Protein phosphatase 2C; Region: PP2C; pfam00481 282458005403 active site 282458005404 Pfam match to entry PF00481 PP2C, Protein phosphatase 2C, score 39.40, E-value 3.4e-10 282458005405 Pfam match to entry PF00481 PP2C, Protein phosphatase 2C, score 3.50, E-value 5.5 282458005406 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 282458005407 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 282458005408 active site 282458005409 ATP binding site [chemical binding]; other site 282458005410 substrate binding site [chemical binding]; other site 282458005411 activation loop (A-loop); other site 282458005412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 282458005413 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 282458005414 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 282458005415 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 282458005416 Pfam match to entry PF00069 pkinase, Protein kinase domain, score 207.00, E-value 3e-58 282458005417 PS00107 Protein kinases ATP-binding region signature. 282458005418 PS00108 Serine/Threonine protein kinases active-site signature. 282458005419 1 probable transmembrane helix predicted for SAR1196 by TMHMM2.0 at aa 350-372 282458005420 Predicted GTPases [General function prediction only]; Region: COG1162 282458005421 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 282458005422 RNA binding site [nucleotide binding]; other site 282458005423 homodimer interface [polypeptide binding]; other site 282458005424 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 282458005425 GTPase/Zn-binding domain interface [polypeptide binding]; other site 282458005426 GTP/Mg2+ binding site [chemical binding]; other site 282458005427 G4 box; other site 282458005428 G5 box; other site 282458005429 G1 box; other site 282458005430 Switch I region; other site 282458005431 G2 box; other site 282458005432 G3 box; other site 282458005433 Switch II region; other site 282458005434 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 282458005435 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005436 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 282458005437 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 282458005438 substrate binding site [chemical binding]; other site 282458005439 hexamer interface [polypeptide binding]; other site 282458005440 metal binding site [ion binding]; metal-binding site 282458005441 Pfam match to entry PF00834 Ribul_P_3_epim, Ribulose-phosphate 3 epimerase, score 350.40, E-value 1.9e-101 282458005442 PS01085 Ribulose-phosphate 3-epimerase signature 1. 282458005443 PS01086 Ribulose-phosphate 3-epimerase signature 2. 282458005444 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 282458005445 Thiamine pyrophosphokinase; Region: TPK; cd07995 282458005446 active site 282458005447 dimerization interface [polypeptide binding]; other site 282458005448 thiamine binding site [chemical binding]; other site 282458005449 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 282458005450 Pfam match to entry PF00830 Ribosomal_L28, Ribosomal L28 family, score 98.00, E-value 1.9e-25 282458005451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 282458005452 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 282458005453 DAK2 domain; Region: Dak2; pfam02734 282458005454 Pfam match to entry PF02734 Dak2, DAK2 domain, score 194.10, E-value 2.2e-54 282458005455 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 282458005456 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 282458005457 generic binding surface II; other site 282458005458 ssDNA binding site; other site 282458005459 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282458005460 ATP binding site [chemical binding]; other site 282458005461 putative Mg++ binding site [ion binding]; other site 282458005462 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282458005463 nucleotide binding region [chemical binding]; other site 282458005464 ATP-binding site [chemical binding]; other site 282458005465 Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase, score 76.90, E-value 2.2e-23 282458005466 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005467 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 85.70, E-value 9.7e-22 282458005468 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 282458005469 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 282458005470 active site 2 [active] 282458005471 active site 1 [active] 282458005472 putative phosphate acyltransferase; Provisional; Region: PRK05331 282458005473 Pfam match to entry PF02504 FA_synthesis, Fatty acid synthesis protein, score 490.50, E-value 1.3e-143 282458005474 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 282458005475 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 282458005476 Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain, score 161.70, E-value 1.3e-44 282458005477 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 282458005478 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 282458005479 NAD(P) binding site [chemical binding]; other site 282458005480 homotetramer interface [polypeptide binding]; other site 282458005481 homodimer interface [polypeptide binding]; other site 282458005482 active site 282458005483 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 334.10, E-value 1.6e-96 282458005484 PS00061 Short-chain dehydrogenases/reductases family signature. 282458005485 acyl carrier protein; Provisional; Region: acpP; PRK00982 282458005486 Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site, score 76.10, E-value 2e-19 282458005487 PS00012 Phosphopantetheine attachment site. 282458005488 ribonuclease III; Reviewed; Region: rnc; PRK00102 282458005489 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 282458005490 dimerization interface [polypeptide binding]; other site 282458005491 active site 282458005492 metal binding site [ion binding]; metal-binding site 282458005493 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 282458005494 dsRNA binding site [nucleotide binding]; other site 282458005495 Pfam match to entry PF00636 Ribonuclease_3, RNase3 domain., score 158.60, E-value 1.1e-43 282458005496 PS00517 Ribonuclease III family signature. 282458005497 Pfam match to entry PF00035 dsrm, Double-stranded RNA binding motif, score 80.90, E-value 2.6e-20 282458005498 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 282458005499 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 282458005500 Walker A/P-loop; other site 282458005501 ATP binding site [chemical binding]; other site 282458005502 Q-loop/lid; other site 282458005503 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 282458005504 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 282458005505 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 282458005506 ABC transporter signature motif; other site 282458005507 Walker B; other site 282458005508 D-loop; other site 282458005509 H-loop/switch region; other site 282458005510 Pfam match to entry PF02463 SMC_N, SMC domain N terminal domain, score 286.30, E-value 3.8e-82 282458005511 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005512 Pfam match to entry PF02483 SMC_C, SMC family, C-terminal domain, score 366.70, E-value 2.4e-106 282458005513 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 282458005514 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 282458005515 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 282458005516 P loop; other site 282458005517 GTP binding site [chemical binding]; other site 282458005518 PS00018 EF-hand calcium-binding domain. 282458005519 Pfam match to entry PF02881 SRP54_N, SRP54-type protein, helical bundle domain, score 68.70, E-value 1.2e-16 282458005520 Pfam match to entry PF00448 SRP54, SRP54-type protein, GTPase domain, score 428.40, E-value 6.3e-125 282458005521 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005522 PS00300 SRP54-type proteins GTP-binding domain signature. 282458005523 putative DNA-binding protein; Validated; Region: PRK00118 282458005524 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 282458005525 Predicted helix-turn-helix motif with score 1776 (+5.24 SD) at aa 39-60, sequence YSLSEIADTFNVSRQAVYDNIR 282458005526 signal recognition particle protein; Provisional; Region: PRK10867 282458005527 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 282458005528 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 282458005529 P loop; other site 282458005530 GTP binding site [chemical binding]; other site 282458005531 Signal peptide binding domain; Region: SRP_SPB; pfam02978 282458005532 Pfam match to entry PF02881 SRP54_N, SRP54-type protein, helical bundle domain, score 117.00, E-value 3.5e-31 282458005533 Pfam match to entry PF00448 SRP54, SRP54-type protein, GTPase domain, score 407.40, E-value 1.3e-118 282458005534 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005535 PS00300 SRP54-type proteins GTP-binding domain signature. 282458005536 Pfam match to entry PF02978 SRP_SPB, SRP54-type protein, GTPase domain, score 179.30, E-value 6.3e-50 282458005537 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 282458005538 Pfam match to entry PF00886 Ribosomal_S16, Ribosomal protein S16, score 116.10, E-value 6.7e-31 282458005539 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 282458005540 RimM N-terminal domain; Region: RimM; pfam01782 282458005541 PRC-barrel domain; Region: PRC; pfam05239 282458005542 Pfam match to entry PF01782 RimM, RimM, score 168.60, E-value 1e-46 282458005543 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 282458005544 Pfam match to entry PF01746 tRNA_m1G_MT, tRNA (Guanine-1)-methyltransferase, score 443.10, E-value 2.4e-129 282458005545 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 282458005546 Pfam match to entry PF01245 Ribosomal_L19, Ribosomal protein L19, score 245.40, E-value 8.1e-70 282458005547 PS01015 Ribosomal protein L19 signature. 282458005548 Signal peptide predicted for SAR1218 by SignalP 2.0 HMM (Signal peptide probabilty 0.912) with cleavage site probability 0.278 between residues 34 and 35; signal peptide 282458005549 Predicted membrane protein [Function unknown]; Region: COG4485 282458005550 13 probable transmembrane helices predicted for SAR1218 by TMHMM2.0 at aa 15-37, 87-109, 124-146, 153-175, 197-228, 249-271, 291-313, 320-342, 357-375, 382-401, 405-427, 432-449 and 843-865 282458005551 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 282458005552 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 282458005553 GTP/Mg2+ binding site [chemical binding]; other site 282458005554 G4 box; other site 282458005555 G5 box; other site 282458005556 G1 box; other site 282458005557 Switch I region; other site 282458005558 G2 box; other site 282458005559 G3 box; other site 282458005560 Switch II region; other site 282458005561 Pfam match to entry PF01926 MMR_HSR1, GTPase of unknown function, score 236.20, E-value 4.7e-67 282458005562 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005563 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 282458005564 RNA/DNA hybrid binding site [nucleotide binding]; other site 282458005565 active site 282458005566 Pfam match to entry PF01351 RNase_HII, Ribonuclease HII, score 207.10, E-value 2.6e-58 282458005567 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 282458005568 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 282458005569 CoA-ligase; Region: Ligase_CoA; pfam00549 282458005570 Pfam match to entry PF02222 ATP-grasp, ATP-grasp domain, score 189.80, E-value 4.4e-53 282458005571 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005572 Pfam match to entry PF00549 ligase-CoA, CoA-ligase, score 235.80, E-value 6.2e-67 282458005573 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 282458005574 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 282458005575 CoA binding domain; Region: CoA_binding; pfam02629 282458005576 CoA-ligase; Region: Ligase_CoA; pfam00549 282458005577 Pfam match to entry PF02629 CoA_binding, Uncharacterized ACR, COG1832, score 217.70, E-value 1.7e-61 282458005578 Pfam match to entry PF00549 ligase-CoA, CoA-ligase, score 184.20, E-value 2e-51 282458005579 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 282458005580 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 282458005581 Signal peptide predicted for SAR1223 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 38 and 39; signal peptide 282458005582 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 282458005583 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282458005584 CHAP domain; Region: CHAP; pfam05257 282458005585 1 probable transmembrane helix predicted for SAR1223 by TMHMM2.0 at aa 12-31 282458005586 Pfam match to entry PF01476 LysM, LysM domain, score 78.50, E-value 1.4e-19 282458005587 FemAB family; Region: FemAB; pfam02388 282458005588 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 282458005589 Pfam match to entry PF02388 FemAB, FemAB family, score 831.50, E-value 2.8e-246 282458005590 DNA protecting protein DprA; Region: dprA; TIGR00732 282458005591 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 282458005592 Pfam match to entry PF02481 SMF, SMF family, score 420.80, E-value 1.2e-122 282458005593 DNA topoisomerase I; Validated; Region: PRK05582 282458005594 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 282458005595 active site 282458005596 interdomain interaction site; other site 282458005597 putative metal-binding site [ion binding]; other site 282458005598 nucleotide binding site [chemical binding]; other site 282458005599 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 282458005600 domain I; other site 282458005601 DNA binding groove [nucleotide binding] 282458005602 phosphate binding site [ion binding]; other site 282458005603 domain II; other site 282458005604 domain III; other site 282458005605 nucleotide binding site [chemical binding]; other site 282458005606 catalytic site [active] 282458005607 domain IV; other site 282458005608 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 282458005609 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 282458005610 Pfam match to entry PF01751 Toprim, Toprim domain, score 136.80, E-value 3.9e-37 282458005611 Pfam match to entry PF01131 Topoisom_bac, DNA topoisomerase, score 607.00, E-value 1.1e-178 282458005612 PS00396 Prokaryotic DNA topoisomerase I active site. 282458005613 Pfam match to entry PF01396 zf-C4_Topoisom, Topoisomerase DNA binding C4 zinc finger, score 73.70, E-value 3.9e-18 282458005614 Pfam match to entry PF01396 zf-C4_Topoisom, Topoisomerase DNA binding C4 zinc finger, score 65.60, E-value 1.1e-15 282458005615 Pfam match to entry PF01396 zf-C4_Topoisom, Topoisomerase DNA binding C4 zinc finger, score 1.20, E-value 1.2 282458005616 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 282458005617 Glucose inhibited division protein A; Region: GIDA; pfam01134 282458005618 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 282458005619 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 282458005620 active site 282458005621 DNA binding site [nucleotide binding] 282458005622 Int/Topo IB signature motif; other site 282458005623 Pfam match to entry PF02899 Phage_integr_N, Phage integrase, N-terminal SAM-like domain, score 68.10, E-value 1.8e-16 282458005624 Pfam match to entry PF00589 Phage_integrase, Phage integrase, score 172.60, E-value 6.7e-48 282458005625 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 282458005626 active site 282458005627 HslU subunit interaction site [polypeptide binding]; other site 282458005628 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 282458005629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458005630 Walker A motif; other site 282458005631 ATP binding site [chemical binding]; other site 282458005632 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 282458005633 Walker B motif; other site 282458005634 arginine finger; other site 282458005635 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 282458005636 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA), score 19.40, E-value 9e-05 282458005637 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005638 transcriptional repressor CodY; Validated; Region: PRK04158 282458005639 CodY GAF-like domain; Region: CodY; pfam06018 282458005640 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 282458005641 Predicted helix-turn-helix motif with score 1382 (+3.89 SD) at aa 201-222, sequence LIASKVADRVGITRSVIVNALR 282458005642 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 282458005643 rRNA interaction site [nucleotide binding]; other site 282458005644 S8 interaction site; other site 282458005645 putative laminin-1 binding site; other site 282458005646 PS00962 Ribosomal protein S2 signature 1. 282458005647 Pfam match to entry PF00318 Ribosomal_S2, Ribosomal protein S2, score 365.40, E-value 5.9e-106 282458005648 PS00963 Ribosomal protein S2 signature 2. 282458005649 elongation factor Ts; Provisional; Region: tsf; PRK09377 282458005650 UBA/TS-N domain; Region: UBA; pfam00627 282458005651 Elongation factor TS; Region: EF_TS; pfam00889 282458005652 Elongation factor TS; Region: EF_TS; pfam00889 282458005653 Pfam match to entry PF02094 TS-N, TS-N domain, score 83.70, E-value 3.7e-21 282458005654 PS01126 Elongation factor Ts signature 1. 282458005655 Pfam match to entry PF00889 EF_TS, Elongation factor TS, score 347.40, E-value 1.5e-100 282458005656 PS01127 Elongation factor Ts signature 2. 282458005657 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 282458005658 putative nucleotide binding site [chemical binding]; other site 282458005659 uridine monophosphate binding site [chemical binding]; other site 282458005660 homohexameric interface [polypeptide binding]; other site 282458005661 Pfam match to entry PF00696 aakinase, Amino acid kinase, score 224.40, E-value 1.7e-63 282458005662 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005663 ribosome recycling factor; Reviewed; Region: frr; PRK00083 282458005664 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 282458005665 hinge region; other site 282458005666 Pfam match to entry PF01765 RRF, Ribosome recycling factor, score 346.90, E-value 2.2e-100 282458005667 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 282458005668 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 282458005669 catalytic residue [active] 282458005670 putative FPP diphosphate binding site; other site 282458005671 putative FPP binding hydrophobic cleft; other site 282458005672 dimer interface [polypeptide binding]; other site 282458005673 putative IPP diphosphate binding site; other site 282458005674 Pfam match to entry PF01255 UPP_synthetase, UDP diphosphate synthase, score 335.10, E-value 7.8e-97 282458005675 PS01066 UDP pyrophosphate synthetase signature. 282458005676 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 282458005677 Signal peptide predicted for SAR1237 by SignalP 2.0 HMM (Signal peptide probabilty 0.963) with cleavage site probability 0.943 between residues 30 and 31; signal peptide 282458005678 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 282458005679 Pfam match to entry PF01148 Cytidylyltrans, Phosphatidate cytidylyltransferase, score 56.20, E-value 7e-13 282458005680 7 probable transmembrane helices predicted for SAR1237 by TMHMM2.0 at aa 7-29, 44-66, 73-95, 100-122, 129-151, 171-190 and 197-216 282458005681 PS01315 Phosphatidate cytidylyltransferase signature. 282458005682 RIP metalloprotease RseP; Region: TIGR00054 282458005683 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 282458005684 active site 282458005685 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 282458005686 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 282458005687 protein binding site [polypeptide binding]; other site 282458005688 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 282458005689 putative substrate binding region [chemical binding]; other site 282458005690 5 probable transmembrane helices predicted for SAR1238 by TMHMM2.0 at aa 4-21, 172-194, 307-329, 350-372 and 401-420 282458005691 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282458005692 Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF)., score 10.90, E-value 0.1 282458005693 prolyl-tRNA synthetase; Provisional; Region: PRK09194 282458005694 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 282458005695 dimer interface [polypeptide binding]; other site 282458005696 motif 1; other site 282458005697 active site 282458005698 motif 2; other site 282458005699 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 282458005700 putative deacylase active site [active] 282458005701 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 282458005702 active site 282458005703 motif 3; other site 282458005704 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 282458005705 anticodon binding site; other site 282458005706 Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T), score 38.20, E-value 1.9e-07 282458005707 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 282458005708 DNA polymerase III PolC; Validated; Region: polC; PRK00448 282458005709 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 282458005710 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 282458005711 generic binding surface II; other site 282458005712 generic binding surface I; other site 282458005713 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 282458005714 active site 282458005715 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 282458005716 active site 282458005717 catalytic site [active] 282458005718 substrate binding site [chemical binding]; other site 282458005719 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 282458005720 Pfam match to entry PF02231 PHP_N, PHP domain N-terminal region, score 105.70, E-value 8.7e-28 282458005721 Pfam match to entry PF00929 Exonuclease, Exonuclease, score 212.50, E-value 6.3e-60 282458005722 Pfam match to entry PF02811 PHP_C, PHP domain C-terminal region, score 97.70, E-value 2.3e-25 282458005723 ribosome maturation protein RimP; Reviewed; Region: PRK00092 282458005724 Sm and related proteins; Region: Sm_like; cl00259 282458005725 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 282458005726 putative oligomer interface [polypeptide binding]; other site 282458005727 putative RNA binding site [nucleotide binding]; other site 282458005728 Pfam match to entry PF02576 DUF150, Uncharacterized BCR, YhbC family COG0779, score 166.90, E-value 3.3e-46 282458005729 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 282458005730 NusA N-terminal domain; Region: NusA_N; pfam08529 282458005731 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 282458005732 RNA binding site [nucleotide binding]; other site 282458005733 homodimer interface [polypeptide binding]; other site 282458005734 NusA-like KH domain; Region: KH_5; pfam13184 282458005735 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 282458005736 G-X-X-G motif; other site 282458005737 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 27.30, E-value 6e-06 282458005738 Pfam match to entry PF00013 KH-domain, KH domain, score 0.40, E-value 4.7 282458005739 Pfam match to entry PF00013 KH-domain, KH domain, score 31.50, E-value 1.9e-05 282458005740 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 282458005741 putative RNA binding cleft [nucleotide binding]; other site 282458005742 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 282458005743 Pfam match to entry PF01248 Ribosomal_L7Ae, Ribosomal protein L7Ae/L30e/S12e/Gadd45 family, score 61.10, E-value 2.3e-14 282458005744 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 282458005745 translation initiation factor IF-2; Region: IF-2; TIGR00487 282458005746 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 282458005747 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 282458005748 G1 box; other site 282458005749 putative GEF interaction site [polypeptide binding]; other site 282458005750 GTP/Mg2+ binding site [chemical binding]; other site 282458005751 Switch I region; other site 282458005752 G2 box; other site 282458005753 G3 box; other site 282458005754 Switch II region; other site 282458005755 G4 box; other site 282458005756 G5 box; other site 282458005757 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 282458005758 Translation-initiation factor 2; Region: IF-2; pfam11987 282458005759 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 282458005760 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family, score 253.50, E-value 3e-72 282458005761 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005762 Pfam match to entry PF02131 IF2, Initiation factor 2, score 279.60, E-value 4.1e-80 282458005763 PS01176 Initiation factor 2 signature. 282458005764 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 282458005765 Pfam match to entry PF02033 RBFA, Ribosome-binding factor A, score 163.50, E-value 3.5e-45 282458005766 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 282458005767 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 282458005768 RNA binding site [nucleotide binding]; other site 282458005769 active site 282458005770 Pfam match to entry PF01509 TruB_N, TruB family pseudouridylate synthase (N terminal domain), score 234.70, E-value 1.3e-66 282458005771 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 282458005772 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 282458005773 active site 282458005774 Riboflavin kinase; Region: Flavokinase; smart00904 282458005775 Pfam match to entry PF01687 FAD_Synth, Riboflavin kinase / FAD synthetase, score 195.40, E-value 9.1e-55 282458005776 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 282458005777 16S/18S rRNA binding site [nucleotide binding]; other site 282458005778 S13e-L30e interaction site [polypeptide binding]; other site 282458005779 25S rRNA binding site [nucleotide binding]; other site 282458005780 Pfam match to entry PF00312 Ribosomal_S15, Ribosomal protein S15, score 136.70, E-value 4.2e-37 282458005781 PS00362 Ribosomal protein S15 signature. 282458005782 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 282458005783 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 282458005784 RNase E interface [polypeptide binding]; other site 282458005785 trimer interface [polypeptide binding]; other site 282458005786 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 282458005787 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 282458005788 RNase E interface [polypeptide binding]; other site 282458005789 trimer interface [polypeptide binding]; other site 282458005790 active site 282458005791 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 282458005792 putative nucleic acid binding region [nucleotide binding]; other site 282458005793 G-X-X-G motif; other site 282458005794 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 282458005795 RNA binding site [nucleotide binding]; other site 282458005796 domain interface; other site 282458005797 Pfam match to entry PF01138 RNase_PH, 3' exoribonuclease, score 218.10, E-value 1.3e-61 282458005798 Pfam match to entry PF01138 RNase_PH, 3' exoribonuclease, score 294.70, E-value 1.1e-84 282458005799 Pfam match to entry PF00013 KH-domain, KH domain, score 43.30, E-value 5.4e-09 282458005800 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 88.40, E-value 7.8e-23 282458005801 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 282458005802 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 282458005803 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 282458005804 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 63.50, E-value 4.5e-15 282458005805 Pfam match to entry PF02147 UPF0036, Uncharacterized protein family UPF0036, score 360.30, E-value 2e-104 282458005806 Signal peptide predicted for SAR1252 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.528 between residues 55 and 56; signal peptide 282458005807 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 282458005808 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 282458005809 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 282458005810 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 282458005811 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 282458005812 5 probable transmembrane helices predicted for SAR1252 by TMHMM2.0 at aa 31-53, 63-85, 97-119, 134-151 and 158-180 282458005813 Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family, score 280.40, E-value 2.3e-80 282458005814 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005815 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 282458005816 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 282458005817 DNA-binding site [nucleotide binding]; DNA binding site 282458005818 UTRA domain; Region: UTRA; pfam07702 282458005819 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 282458005820 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 282458005821 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 282458005822 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 282458005823 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 282458005824 Pfam match to entry PF00675 Peptidase_M16, Insulinase (Peptidase M16), score 8.80, E-value 0.00027 282458005825 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 282458005826 classical (c) SDRs; Region: SDR_c; cd05233 282458005827 NAD(P) binding site [chemical binding]; other site 282458005828 active site 282458005829 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 130.20, E-value 3.9e-35 282458005830 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 282458005831 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 282458005832 Pfam match to entry PF01842 ACT, ACT domain, score 17.50, E-value 0.32 282458005833 1 probable transmembrane helix predicted for SAR1257 by TMHMM2.0 at aa 21-43 282458005834 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005835 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 282458005836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282458005837 non-specific DNA binding site [nucleotide binding]; other site 282458005838 salt bridge; other site 282458005839 sequence-specific DNA binding site [nucleotide binding]; other site 282458005840 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 20.10, E-value 0.054 282458005841 Predicted helix-turn-helix motif with score 1176 (+3.19 SD) at aa 17-38, sequence MTLTELEQRTGIKREMLVHIEN 282458005842 1 probable transmembrane helix predicted for SAR1258 by TMHMM2.0 at aa 107-129 282458005843 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 282458005844 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 282458005845 4 probable transmembrane helices predicted for SAR1259 by TMHMM2.0 at aa 7-29, 44-63, 84-106 and 157-179 282458005846 Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase, score 130.90, E-value 2.3e-35 282458005847 PS00379 CDP-alcohol phosphatidyltransferases signature. 282458005848 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 282458005849 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 282458005850 putative MPT binding site; other site 282458005851 recombinase A; Provisional; Region: recA; PRK09354 282458005852 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 282458005853 hexamer interface [polypeptide binding]; other site 282458005854 Walker A motif; other site 282458005855 ATP binding site [chemical binding]; other site 282458005856 Walker B motif; other site 282458005857 Pfam match to entry PF00154 recA, recA bacterial DNA recombination protein, score 811.30, E-value 3.6e-240 282458005858 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005859 PS00321 recA signature. 282458005860 Signal peptide predicted for SAR1262 by SignalP 2.0 HMM (Signal peptide probabilty 0.960) with cleavage site probability 0.569 between residues 35 and 36; signal peptide 282458005861 phosphodiesterase; Provisional; Region: PRK12704 282458005862 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 282458005863 Zn2+ binding site [ion binding]; other site 282458005864 Mg2+ binding site [ion binding]; other site 282458005865 1 probable transmembrane helix predicted for SAR1262 by TMHMM2.0 at aa 2-24 282458005866 Pfam match to entry PF00013 KH-domain, KH domain, score 26.80, E-value 0.00051 282458005867 Pfam match to entry PF01966 HD, HD domain, score 92.10, E-value 1.1e-23 282458005868 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 282458005869 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 282458005870 putative active site [active] 282458005871 metal binding site [ion binding]; metal-binding site 282458005872 homodimer binding site [polypeptide binding]; other site 282458005873 Pfam match to entry PF02640 DUF189, Uncharacterized BCR, YmdB family COG1692, score 480.20, E-value 1.6e-140 282458005874 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 282458005875 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 282458005876 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 282458005877 dimer interface [polypeptide binding]; other site 282458005878 PYR/PP interface [polypeptide binding]; other site 282458005879 TPP binding site [chemical binding]; other site 282458005880 substrate binding site [chemical binding]; other site 282458005881 Pfam match to entry PF01558 POR, Pyruvate ferredoxin/flavodoxin oxidoreductase, score 29.00, E-value 2.6e-07 282458005882 Pfam match to entry PF01855 POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain, score 283.20, E-value 3.3e-81 282458005883 Pfam match to entry PF02780 transketolase_C, Transketolase, C-terminal domain, score -27.40, E-value 2 282458005884 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 282458005885 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 282458005886 TPP-binding site [chemical binding]; other site 282458005887 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 282458005888 Pfam match to entry PF02775 TPP_enzymes_C, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score -32.50, E-value 0.0025 282458005889 Uncharacterized conserved protein [Function unknown]; Region: COG0011 282458005890 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 282458005891 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 282458005892 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282458005893 FeS/SAM binding site; other site 282458005894 TRAM domain; Region: TRAM; pfam01938 282458005895 Pfam match to entry PF00919 UPF0004, Uncharacterized protein family UPF0004, score 173.90, E-value 2.6e-48 282458005896 PS01278 Uncharacterized protein family UPF0004 signature. 282458005897 Pfam match to entry PF01938 TRAM, Domain of unknown function DUF90, score 56.70, E-value 5.1e-13 282458005898 Predicted membrane protein [Function unknown]; Region: COG4550 282458005899 Predicted membrane protein [Function unknown]; Region: COG4732 282458005900 Signal peptide predicted for SAR1270 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 32 and 33; signal peptide 282458005901 5 probable transmembrane helices predicted for SAR1270 by TMHMM2.0 at aa 6-28, 37-59, 69-91, 98-120 and 130-152 282458005902 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 282458005903 MutS domain I; Region: MutS_I; pfam01624 282458005904 MutS domain II; Region: MutS_II; pfam05188 282458005905 MutS domain III; Region: MutS_III; pfam05192 282458005906 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 282458005907 Walker A/P-loop; other site 282458005908 ATP binding site [chemical binding]; other site 282458005909 Q-loop/lid; other site 282458005910 ABC transporter signature motif; other site 282458005911 Walker B; other site 282458005912 D-loop; other site 282458005913 H-loop/switch region; other site 282458005914 Pfam match to entry PF01624 MutS_N, MutS family, N-terminal DNA binding domain, score 600.70, E-value 8.7e-177 282458005915 Pfam match to entry PF00488 MutS_C, DNA mismatch repair proteins, mutS family, score 481.10, E-value 8.7e-141 282458005916 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005917 PS00486 DNA mismatch repair proteins mutS family signature. 282458005918 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 282458005919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458005920 ATP binding site [chemical binding]; other site 282458005921 Mg2+ binding site [ion binding]; other site 282458005922 G-X-G motif; other site 282458005923 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 282458005924 ATP binding site [chemical binding]; other site 282458005925 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 282458005926 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 32.50, E-value 1.3e-07 282458005927 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 282458005928 Pfam match to entry PF01119 DNA_mis_repair, DNA mismatch repair protein, score 229.40, E-value 5.4e-65 282458005929 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005930 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 282458005931 Signal peptide predicted for SAR1274 by SignalP 2.0 HMM (Signal peptide probabilty 0.848) with cleavage site probability 0.453 between residues 32 and 33; signal peptide 282458005932 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 282458005933 amphipathic channel; other site 282458005934 Asn-Pro-Ala signature motifs; other site 282458005935 Pfam match to entry PF00230 MIP, Major intrinsic protein, score 184.90, E-value 1.7e-59 282458005936 7 probable transmembrane helices predicted for SAR1274 by TMHMM2.0 at aa 5-27, 39-61, 81-103, 131-153, 163-185, 211-233 and 237-259 282458005937 PS00221 MIP family signature. 282458005938 glycerol kinase; Provisional; Region: glpK; PRK00047 282458005939 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 282458005940 N- and C-terminal domain interface [polypeptide binding]; other site 282458005941 active site 282458005942 MgATP binding site [chemical binding]; other site 282458005943 catalytic site [active] 282458005944 metal binding site [ion binding]; metal-binding site 282458005945 glycerol binding site [chemical binding]; other site 282458005946 homotetramer interface [polypeptide binding]; other site 282458005947 homodimer interface [polypeptide binding]; other site 282458005948 FBP binding site [chemical binding]; other site 282458005949 protein IIAGlc interface [polypeptide binding]; other site 282458005950 Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases, N-terminal domain, score 411.00, E-value 1.1e-119 282458005951 Pfam match to entry PF02782 FGGY_C, FGGY family of carbohydrate kinases, C-terminal domain, score 330.00, E-value 2.7e-95 282458005952 PS00445 FGGY family of carbohydrate kinases signature 2. 282458005953 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 282458005954 Pfam match to entry PF01266 DAO, D-amino acid oxidase, score 410.00, E-value 2.2e-119 282458005955 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 282458005956 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 282458005957 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 282458005958 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 282458005959 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 282458005960 Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold, score 43.20, E-value 5.7e-09 282458005961 Signal peptide predicted for SAR1278 by SignalP 2.0 HMM (Signal peptide probabilty 0.805) with cleavage site probability 0.661 between residues 18 and 19; signal peptide 282458005962 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 282458005963 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 282458005964 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005965 Pfam match to entry PF01715 IPPT, IPP transferase, score 351.60, E-value 8.6e-102 282458005966 bacterial Hfq-like; Region: Hfq; cd01716 282458005967 hexamer interface [polypeptide binding]; other site 282458005968 Sm1 motif; other site 282458005969 RNA binding site [nucleotide binding]; other site 282458005970 Sm2 motif; other site 282458005971 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 282458005972 catalytic residues [active] 282458005973 dimer interface [polypeptide binding]; other site 282458005974 Pfam match to entry PF00255 GSHPx, Glutathione peroxidase, score 169.70, E-value 4.8e-47 282458005975 PS00763 Glutathione peroxidases signature 2. 282458005976 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 282458005977 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 282458005978 HflX GTPase family; Region: HflX; cd01878 282458005979 G1 box; other site 282458005980 GTP/Mg2+ binding site [chemical binding]; other site 282458005981 Switch I region; other site 282458005982 G2 box; other site 282458005983 G3 box; other site 282458005984 Switch II region; other site 282458005985 G4 box; other site 282458005986 G5 box; other site 282458005987 PS00017 ATP/GTP-binding site motif A (P-loop). 282458005988 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 282458005989 Aluminium resistance protein; Region: Alum_res; pfam06838 282458005990 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 282458005991 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 282458005992 DNA binding residues [nucleotide binding] 282458005993 putative dimer interface [polypeptide binding]; other site 282458005994 Predicted helix-turn-helix motif with score 1281 (+3.55 SD) at aa 14-35, sequence FSMSVVSKLTDLTPRQIRYYET 282458005995 Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family, score 45.40, E-value 1.3e-09 282458005996 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 282458005997 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 282458005998 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 282458005999 Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 612.80, E-value 7.8e-195 282458006000 PS00180 Glutamine synthetase signature 1. 282458006001 PS00181 Glutamine synthetase ATP-binding region signature. 282458006002 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 282458006003 Similar to Staphylococcus aureus prophage phiPV83 tansposase TR:Q9MBM9 (EMBL:AB044554) (328 aa) fasta scores: E(): 2.2e-30, 34.936% id in 312 aa, and to Bacillus halodurans transposase BH3503 TR:Q9JWR3 (EMBL:AP001520) (314 aa) fasta scores: E(): 2.4e-29, 38.079% id in 302 aa. Contains a frameshift after codon 164. Frameshift occurs at a poly A pentamer; transposase (pseudogene) 282458006004 Pfam match to entry PF00665 rve, Integrase core domain, score 63.50, E-value 3.4e-17 282458006005 PS01043 Transposases, IS30 family, signature. 282458006006 Signal peptide predicted for SAR1288 by SignalP 2.0 HMM (Signal peptide probabilty 0.928) with cleavage site probability 0.488 between residues 19 and 20; signal peptide 282458006007 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 282458006008 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458006009 Signal peptide predicted for SAR1289 by SignalP 2.0 HMM (Signal peptide probabilty 0.981) with cleavage site probability 0.425 between residues 23 and 24; signal peptide 282458006010 1 probable transmembrane helix predicted for SAR1289 by TMHMM2.0 at aa 5-23 282458006011 Signal peptide predicted for SAR1290 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.688 between residues 32 and 33; signal peptide 282458006012 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 282458006013 Surface antigen [General function prediction only]; Region: COG3942 282458006014 CHAP domain; Region: CHAP; pfam05257 282458006015 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006016 1 probable transmembrane helix predicted for SAR1290 by TMHMM2.0 at aa 7-26 282458006017 Signal peptide predicted for SAR1291 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.757 between residues 26 and 27; signal peptide 282458006018 ribonuclease E; Reviewed; Region: rne; PRK10811 282458006019 7 probable transmembrane helices predicted for SAR1291 by TMHMM2.0 at aa 5-27, 121-143, 155-177, 283-305, 312-334, 349-369 and 382-399 282458006020 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 282458006021 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 282458006022 Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family, score 74.40, E-value 2.3e-18 282458006023 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006024 2 probable transmembrane helices predicted for SAR1292 by TMHMM2.0 at aa 20-42 and 65-87 282458006025 AAA-like domain; Region: AAA_10; pfam12846 282458006026 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006027 TcpE family; Region: TcpE; pfam12648 282458006028 3 probable transmembrane helices predicted for SAR1294 by TMHMM2.0 at aa 35-54, 58-77 and 90-107 282458006029 2 probable transmembrane helices predicted for SAR1295 by TMHMM2.0 at aa 20-42 and 49-66 282458006030 Signal peptide predicted for SAR1296 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.500 between residues 61 and 62; signal peptide 282458006031 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 282458006032 1 probable transmembrane helix predicted for SAR1296 by TMHMM2.0 at aa 40-59 282458006033 Replication initiation factor; Region: Rep_trans; pfam02486 282458006034 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 282458006035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 282458006036 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 282458006037 Predicted helix-turn-helix motif with score 1336 (+3.74 SD) at aa 16-37, sequence LTGYEISKKTGVSQYVLSQLRQ 282458006038 insertion sequence ISX 282458006039 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 282458006040 Helix-turn-helix domain; Region: HTH_38; pfam13936 282458006041 Integrase core domain; Region: rve; pfam00665 282458006042 Pfam match to entry PF00665 rve, Integrase core domain, score 115.50, E-value 3.3e-32 282458006043 Predicted helix-turn-helix motif with score 1647 (+4.80 SD) at aa 22-43, sequence YSLRSIARKLKRSVSTISREIS 282458006044 Similar to Bacillus thuringiensis insertion sequence IS232 ATP-binding protein SW:ISTB_BACTB (Q99338) (250 aa) fasta scores: E(): 3e-18, 34.800% id in 250 aa, and to Yersinia pestis hypothetical protein Y1094 TR:P74994 (EMBL:U59875) (259 aa) fasta scores: E(): 8.5e-17, 35.500% id in 200 aa. Contains nonsense (ochre)and frameshift mutations after codons 30 and 102 respectively; insertion sequence protein (pseudogene) 282458006045 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 282458006046 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 282458006047 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 282458006048 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 282458006049 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 282458006050 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 282458006051 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282458006052 catalytic residue [active] 282458006053 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 282458006054 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 282458006055 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 282458006056 putative active site [active] 282458006057 catalytic site [active] 282458006058 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 282458006059 putative active site [active] 282458006060 catalytic site [active] 282458006061 2 probable transmembrane helices predicted for SAR1328 by TMHMM2.0 at aa 10-32 and 44-66 282458006062 Pfam match to entry PF00614 PLDc, Phospholipase D. Active site motif, score 39.30, E-value 9e-08 282458006063 Pfam match to entry PF00614 PLDc, Phospholipase D. Active site motif, score 33.10, E-value 6.6e-06 282458006064 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 282458006065 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 282458006066 Walker A/P-loop; other site 282458006067 ATP binding site [chemical binding]; other site 282458006068 Q-loop/lid; other site 282458006069 ABC transporter signature motif; other site 282458006070 Walker B; other site 282458006071 D-loop; other site 282458006072 H-loop/switch region; other site 282458006073 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 129.00, E-value 8.6e-35 282458006074 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006075 PS00211 ABC transporters family signature. 282458006076 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 282458006077 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 282458006078 6 probable transmembrane helices predicted for SAR1330 by TMHMM2.0 at aa 20-37, 52-74, 95-117, 137-156, 163-182 and 214-236 282458006079 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 282458006080 Histidine kinase; Region: HisKA_3; pfam07730 282458006081 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 282458006082 ATP binding site [chemical binding]; other site 282458006083 Mg2+ binding site [ion binding]; other site 282458006084 G-X-G motif; other site 282458006085 6 probable transmembrane helices predicted for SAR1331 by TMHMM2.0 at aa 7-26, 31-53, 60-79, 83-100, 107-126 and 130-149 282458006086 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 14.50, E-value 0.013 282458006087 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 9.10, E-value 0.39 282458006088 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 282458006089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458006090 active site 282458006091 phosphorylation site [posttranslational modification] 282458006092 intermolecular recognition site; other site 282458006093 dimerization interface [polypeptide binding]; other site 282458006094 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 103.80, E-value 3.4e-27 282458006095 2 probable transmembrane helices predicted for SAR1333 by TMHMM2.0 at aa 9-28 and 32-54 282458006096 Signal peptide predicted for SAR1334 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.372 between residues 33 and 34; signal peptide 282458006097 Staphylococcal nuclease homologues; Region: SNc; smart00318 282458006098 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 282458006099 Catalytic site; other site 282458006100 1 probable transmembrane helix predicted for SAR1334 by TMHMM2.0 at aa 7-24 282458006101 Pfam match to entry PF00565 SNase, Staphylococcal nuclease homologues, score 177.60, E-value 2e-49 282458006102 PS01284 Thermonuclease signature 2. 282458006103 Signal peptide predicted for SAR1335 by SignalP 2.0 HMM (Signal peptide probabilty 0.892) with cleavage site probability 0.553 between residues 25 and 26; signal peptide 282458006104 AAA domain; Region: AAA_11; pfam13086 282458006105 1 probable transmembrane helix predicted for SAR1335 by TMHMM2.0 at aa 4-21 282458006106 aspartate kinase; Reviewed; Region: PRK09034 282458006107 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 282458006108 putative catalytic residues [active] 282458006109 putative nucleotide binding site [chemical binding]; other site 282458006110 putative aspartate binding site [chemical binding]; other site 282458006111 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 282458006112 allosteric regulatory residue; other site 282458006113 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 282458006114 Pfam match to entry PF01842 ACT, ACT domain, score 23.20, E-value 0.0062 282458006115 Pfam match to entry PF01842 ACT, ACT domain, score 13.80, E-value 2.2 282458006116 Pfam match to entry PF00696 aakinase, Amino acid kinase, score 128.80, E-value 1e-34 282458006117 PS00324 Aspartokinase signature. 282458006118 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 282458006119 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 282458006120 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 282458006121 Pfam match to entry PF00742 Homoserine_dh, Homoserine dehydrogenase, score 385.40, E-value 5.6e-112 282458006122 PS01042 Homoserine dehydrogenase signature. 282458006123 threonine synthase; Reviewed; Region: PRK06721 282458006124 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 282458006125 homodimer interface [polypeptide binding]; other site 282458006126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458006127 catalytic residue [active] 282458006128 Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme, score 339.70, E-value 3.1e-98 282458006129 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 282458006130 Pfam match to entry PF02225 PA, PA domain, score 2.50, E-value 0.57 282458006131 homoserine kinase; Provisional; Region: PRK01212 282458006132 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 282458006133 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 282458006134 Pfam match to entry PF00288 GHMP_kinases, GHMP kinases ATP-binding protein, score 39.80, E-value 8.6e-10 282458006135 PS00627 GHMP kinases ATP-binding domain. 282458006136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458006137 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 282458006138 active site 282458006139 motif I; other site 282458006140 motif II; other site 282458006141 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 282458006142 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 36.50, E-value 6.1e-07 282458006143 Signal peptide predicted for SAR1343 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.541 between residues 39 and 40; signal peptide 282458006144 lysine transporter; Provisional; Region: PRK10836 282458006145 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score 587.00, E-value 1.2e-172 282458006146 11 probable transmembrane helices predicted for SAR1343 by TMHMM2.0 at aa 15-37, 44-66, 93-115, 122-144, 159-181, 239-261, 284-306, 338-357, 367-389, 409-431 and 446-463 282458006147 PS00218 Amino acid permeases signature. 282458006148 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 282458006149 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 282458006150 tetramer interface [polypeptide binding]; other site 282458006151 heme binding pocket [chemical binding]; other site 282458006152 NADPH binding site [chemical binding]; other site 282458006153 Pfam match to entry PF00199 catalase, Catalase, score 871.40, E-value 2.8e-258 282458006154 PS00438 Catalase proximal active site signature. 282458006155 PS00437 Catalase proximal heme-ligand signature. 282458006156 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 282458006157 Pfam match to entry PF00471 Ribosomal_L33, Ribosomal protein L33, score 92.90, E-value 6.3e-24 282458006158 PS00582 Ribosomal protein L33 signature. 282458006159 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 282458006160 Pfam match to entry PF00253 Ribosomal_S14, Ribosomal protein S14p/S29e, score 133.00, E-value 7.8e-40 282458006161 PS00527 Ribosomal protein S14 signature. 282458006162 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 282458006163 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 282458006164 active site 282458006165 Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus, score 193.40, E-value 3.5e-54 282458006166 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 282458006167 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 282458006168 LexA repressor; Validated; Region: PRK00215 282458006169 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 282458006170 putative DNA binding site [nucleotide binding]; other site 282458006171 putative Zn2+ binding site [ion binding]; other site 282458006172 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 282458006173 Catalytic site [active] 282458006174 Pfam match to entry PF00717 Peptidase_S24, Peptidase S24, score 151.60, E-value 1.3e-41 282458006175 Pfam match to entry PF01726 LexA_DNA_bind, LexA DNA binding domain, score 125.10, E-value 1.3e-33 282458006176 Signal peptide predicted for SAR1350 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.552 between residues 37 and 38; signal peptide 282458006177 1 probable transmembrane helix predicted for SAR1350 by TMHMM2.0 at aa 13-35 282458006178 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 282458006179 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 282458006180 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 282458006181 TPP-binding site [chemical binding]; other site 282458006182 dimer interface [polypeptide binding]; other site 282458006183 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 282458006184 PYR/PP interface [polypeptide binding]; other site 282458006185 dimer interface [polypeptide binding]; other site 282458006186 TPP binding site [chemical binding]; other site 282458006187 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 282458006188 Pfam match to entry PF00456 transketolase, Transketolase, thiamine diphosphate binding domain, score 615.60, E-value 3e-181 282458006189 PS00801 Transketolase signature 1. 282458006190 Pfam match to entry PF02779 transket_pyr, Transketolase, central domain, score 186.30, E-value 4.8e-52 282458006191 PS00802 Transketolase signature 2. 282458006192 Pfam match to entry PF02780 transketolase_C, Transketolase, C-terminal domain, score 18.90, E-value 0.00052 282458006193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 282458006194 1 probable transmembrane helix predicted for SAR1353 by TMHMM2.0 at aa 4-26 282458006195 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 282458006196 Signal peptide predicted for SAR1355 by SignalP 2.0 HMM (Signal peptide probabilty 0.732) with cleavage site probability 0.532 between residues 27 and 28; signal peptide 282458006197 5 probable transmembrane helices predicted for SAR1355 by TMHMM2.0 at aa 4-21, 34-56, 61-83, 95-114 and 124-143 282458006198 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 282458006199 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 282458006200 active site 282458006201 metal binding site [ion binding]; metal-binding site 282458006202 DNA binding site [nucleotide binding] 282458006203 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 282458006204 Pfam match to entry PF02549 DNA_repair, DNA repair exonuclease, score 170.90, E-value 2e-47 282458006205 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 282458006206 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 282458006207 Walker A/P-loop; other site 282458006208 ATP binding site [chemical binding]; other site 282458006209 Q-loop/lid; other site 282458006210 Walker B; other site 282458006211 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 282458006212 ABC transporter signature motif; other site 282458006213 Walker B; other site 282458006214 D-loop; other site 282458006215 H-loop/switch region; other site 282458006216 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006217 insertion sequence ISZ 282458006218 Transposase; Region: HTH_Tnp_1; cl17663 282458006219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 282458006220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 282458006221 Helix-turn-helix domain; Region: HTH_28; pfam13518 282458006222 Pfam match to entry PF01527 Transposase_8, Transposase, score 47.20, E-value 3.6e-10 282458006223 Predicted helix-turn-helix motif with score 2127 (+6.43 SD) at aa 155-176, sequence QSYREVAEHFNISYGQIYQWVH 282458006224 insertion sequence ISY 282458006225 HTH-like domain; Region: HTH_21; pfam13276 282458006226 Integrase core domain; Region: rve; pfam00665 282458006227 Integrase core domain; Region: rve_3; cl15866 282458006228 Pfam match to entry PF00665 rve, Integrase core domain, score 95.20, E-value 2.4e-26 282458006229 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 282458006230 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 282458006231 Pfam match to entry PF01741 MscL, Large-conductance mechanosensitive channel, MscL, score 260.60, E-value 2e-74 282458006232 2 probable transmembrane helices predicted for SAR1360 by TMHMM2.0 at aa 13-35 and 65-84 282458006233 PS01327 Large-conductance mechanosensitive channels mscL family signature. 282458006234 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 282458006235 11 probable transmembrane helices predicted for SAR1361 by TMHMM2.0 at aa 15-35, 56-78, 93-115, 190-212, 232-254, 263-285, 321-340, 353-375, 400-422, 443-465 and 475-497 282458006236 Pfam match to entry PF02028 BCCT, BCCT family transporter, score 756.30, E-value 1.2e-223 282458006237 PS01303 BCCT family of transporters signature. 282458006238 aconitate hydratase; Validated; Region: PRK09277 282458006239 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 282458006240 substrate binding site [chemical binding]; other site 282458006241 ligand binding site [chemical binding]; other site 282458006242 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 282458006243 substrate binding site [chemical binding]; other site 282458006244 Pfam match to entry PF00330 aconitase, Aconitase (aconitate hydratase), score 755.70, E-value 2.3e-230 282458006245 PS00450 Aconitase signature 1. 282458006246 PS01244 Aconitase signature 2. 282458006247 Pfam match to entry PF00694 Aconitase_C, Aconitase C-terminal domain, score 217.40, E-value 2.2e-61 282458006248 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 282458006249 active site 282458006250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 282458006251 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 282458006252 Pfam match to entry PF02660 DUF205, Domain of unknown function DUF, score 232.60, E-value 5.5e-66 282458006253 5 probable transmembrane helices predicted for SAR1365 by TMHMM2.0 at aa 4-26, 52-74, 84-106, 118-140 and 150-182 282458006254 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 282458006255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458006256 ATP binding site [chemical binding]; other site 282458006257 Mg2+ binding site [ion binding]; other site 282458006258 G-X-G motif; other site 282458006259 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 282458006260 anchoring element; other site 282458006261 dimer interface [polypeptide binding]; other site 282458006262 ATP binding site [chemical binding]; other site 282458006263 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 282458006264 active site 282458006265 putative metal-binding site [ion binding]; other site 282458006266 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 282458006267 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 103.30, E-value 3.4e-27 282458006268 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006269 Pfam match to entry PF00204 DNA_topoisoII, DNA topoisomerase II (N-terminal region), score 335.90, E-value 4.6e-97 282458006270 Pfam match to entry PF01751 Toprim, Toprim domain, score 30.20, E-value 4.6e-05 282458006271 PS00177 DNA topoisomerase II signature. 282458006272 Pfam match to entry PF00986 DNA_gyraseB_C, DNA gyrase B subunit, carboxyl terminus, score 157.60, E-value 2.2e-43 282458006273 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 282458006274 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 282458006275 CAP-like domain; other site 282458006276 active site 282458006277 primary dimer interface [polypeptide binding]; other site 282458006278 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 282458006279 Pfam match to entry PF00521 DNA_topoisoIV, DNA gyrase/topoisomerase IV, subunit A, score 971.90, E-value 0 282458006280 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 282458006281 amino acid carrier protein; Region: agcS; TIGR00835 282458006282 9 probable transmembrane helices predicted for SAR1368 by TMHMM2.0 at aa 22-41, 90-112, 155-172, 193-215, 219-241, 309-331, 357-379, 392-411 and 422-444 282458006283 Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family, score 694.20, E-value 6.3e-205 282458006284 PS00873 Sodium:alanine symporter family signature. 282458006285 CAT RNA binding domain; Region: CAT_RBD; smart01061 282458006286 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 282458006287 PRD domain; Region: PRD; pfam00874 282458006288 PRD domain; Region: PRD; pfam00874 282458006289 Pfam match to entry PF00874 BglG_antitermin, Transcriptional antiterminator bglG family, score 101.90, E-value 1.3e-26 282458006290 PS00654 Transcriptional antiterminators bglG family signature. 282458006291 Pfam match to entry PF00874 BglG_antitermin, Transcriptional antiterminator bglG family, score 32.40, E-value 5.2e-06 282458006292 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 282458006293 Domain of unknown function DUF20; Region: UPF0118; pfam01594 282458006294 8 probable transmembrane helices predicted for SAR1371 by TMHMM2.0 at aa 23-45, 55-77, 97-119, 182-204, 242-264, 269-291, 296-318 and 338-360 282458006295 Pfam match to entry PF01594 UPF0118, Domain of unknown function DUF20, score 304.30, E-value 1.5e-87 282458006296 Predicted integral membrane protein [Function unknown]; Region: COG0392 282458006297 Uncharacterized conserved protein [Function unknown]; Region: COG2898 282458006298 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 282458006299 14 probable transmembrane helices predicted for SAR1372 by TMHMM2.0 at aa 9-31, 51-73, 94-116, 131-153, 162-184, 194-216, 229-251, 271-293, 336-358, 368-390, 397-416, 420-439, 451-473 and 488-510 282458006300 methionine sulfoxide reductase A; Provisional; Region: PRK14054 282458006301 Pfam match to entry PF01625 PMSR, Peptide methionine sulfoxide reductase, score 257.00, E-value 2.5e-73 282458006302 Signal peptide predicted for SAR1374 by SignalP 2.0 HMM (Signal peptide probabilty 0.973) with cleavage site probability 0.357 between residues 53 and 54; signal peptide 282458006303 Transcriptional regulator [Transcription]; Region: LytR; COG1316 282458006304 1 probable transmembrane helix predicted for SAR1374 by TMHMM2.0 at aa 32-54 282458006305 Insertion sequence IS1272 282458006306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 282458006307 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458006308 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 282458006309 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458006310 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 282458006311 active site 1 [active] 282458006312 dimer interface [polypeptide binding]; other site 282458006313 hexamer interface [polypeptide binding]; other site 282458006314 active site 2 [active] 282458006315 Pfam match to entry PF01361 Tautomerase, Tautomerase enzyme, score 51.80, E-value 1.5e-11 282458006316 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 282458006317 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 282458006318 active site 282458006319 DNA binding site [nucleotide binding] 282458006320 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 282458006321 Pfam match to entry PF00817 IMS, impB/mucB/samB family, score 299.30, E-value 4.6e-86 282458006322 prephenate dehydrogenase; Validated; Region: PRK06545 282458006323 prephenate dehydrogenase; Validated; Region: PRK08507 282458006324 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 282458006325 Pfam match to entry PF02153 PDH, Prephenate dehydrogenase, score 292.70, E-value 4.6e-84 282458006326 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 282458006327 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 282458006328 putative oligomer interface [polypeptide binding]; other site 282458006329 putative active site [active] 282458006330 metal binding site [ion binding]; metal-binding site 282458006331 Pfam match to entry PF01546 Peptidase_M20, Peptidase M20/M25/M40, score 15.50, E-value 0.0016 282458006332 anthranilate synthase component I; Provisional; Region: PRK13567 282458006333 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 282458006334 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 282458006335 Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme, score 384.40, E-value 1.1e-111 282458006336 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 282458006337 Glutamine amidotransferase class-I; Region: GATase; pfam00117 282458006338 glutamine binding [chemical binding]; other site 282458006339 catalytic triad [active] 282458006340 Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I, score 152.20, E-value 8.9e-42 282458006341 PS00442 Glutamine amidotransferases class-I active site. 282458006342 Similar to Lactococcus lactis anthranilate phosphoribosyltransferase TrpD SW:TRPD_LACLA (Q02000) (335 aa) fasta scores: E(): 5.6e-37, 38.485% id in 330 aa. Previously sequenced as Staphylococcus aureus anthranilate phosphoribosyltransferase TR:Q9RL77 (EMBL:Y18640) (335 aa) fasta scores: E(): 5.1e-117, 94.627% id in 335 aa. Contains a frameshift after codon 79. Frameshift occurs at TG(x5) repeat;anthranilate phosphoribosyltransferase (pseudogene) 282458006343 Pfam match to entry PF00591 Glycos_transf_3, Glycosyl transferase, a/b domain, score 306.00, E-value 4.5e-88 282458006344 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 282458006345 active site 282458006346 ribulose/triose binding site [chemical binding]; other site 282458006347 phosphate binding site [ion binding]; other site 282458006348 substrate (anthranilate) binding pocket [chemical binding]; other site 282458006349 product (indole) binding pocket [chemical binding]; other site 282458006350 Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthase, score 280.70, E-value 1.9e-80 282458006351 PS00614 Indole-3-glycerol phosphate synthase signature. 282458006352 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282458006353 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 282458006354 active site 282458006355 Pfam match to entry PF00697 PRAI, N-(5'phosphoribosyl)anthranilate (PRA) isomerase, score 112.70, E-value 7.2e-30 282458006356 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 282458006357 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 282458006358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458006359 catalytic residue [active] 282458006360 Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme, score 370.60, E-value 1.6e-107 282458006361 PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 282458006362 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 282458006363 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 282458006364 substrate binding site [chemical binding]; other site 282458006365 active site 282458006366 catalytic residues [active] 282458006367 heterodimer interface [polypeptide binding]; other site 282458006368 Pfam match to entry PF00290 trp_syntA, Tryptophan synthase alpha chain, score 227.10, E-value 2.6e-64 282458006369 PS00167 Tryptophan synthase alpha chain signature. 282458006370 FemAB family; Region: FemAB; pfam02388 282458006371 FlxA-like protein; Region: FlxA; pfam14282 282458006372 Pfam match to entry PF02388 FemAB, FemAB family, score 896.20, E-value 9.5e-266 282458006373 FemAB family; Region: FemAB; pfam02388 282458006374 Pfam match to entry PF02388 FemAB, FemAB family, score 810.20, E-value 7.5e-240 282458006375 Similar to Pasteurella multocida hypothetical protein PM0231 TR:Q9CP34 (EMBL:AE006057) (251 aa) fasta scores: E(): 1e-32, 46.018% id in 226 aa, and to Bacillus halodurans hydrolase BH2692 TR:Q9K9F5 (EMBL:AP001516) (266 aa) fasta scores: E(): 2.5e-05, 22.807% id in 228 aa. Contains a frameshift after codon 55. Frameshift occurs at a poly T pentamer;conserved hypothetical protein (pseudogene) 282458006376 SWIM zinc finger; Region: SWIM; pfam04434 282458006377 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 282458006378 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282458006379 Walker A/P-loop; other site 282458006380 ATP binding site [chemical binding]; other site 282458006381 Q-loop/lid; other site 282458006382 ABC transporter signature motif; other site 282458006383 Walker B; other site 282458006384 D-loop; other site 282458006385 H-loop/switch region; other site 282458006386 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 139.50, E-value 6e-38 282458006387 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006388 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282458006389 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 282458006390 Walker A/P-loop; other site 282458006391 ATP binding site [chemical binding]; other site 282458006392 Q-loop/lid; other site 282458006393 ABC transporter signature motif; other site 282458006394 Walker B; other site 282458006395 D-loop; other site 282458006396 H-loop/switch region; other site 282458006397 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 127.30, E-value 2.9e-34 282458006398 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006399 Signal peptide predicted for SAR1394 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.785 between residues 34 and 35; signal peptide 282458006400 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 282458006401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458006402 dimer interface [polypeptide binding]; other site 282458006403 conserved gate region; other site 282458006404 putative PBP binding loops; other site 282458006405 ABC-ATPase subunit interface; other site 282458006406 5 probable transmembrane helices predicted for SAR1394 by TMHMM2.0 at aa 10-29, 73-95, 115-137, 190-212 and 232-254 282458006407 Signal peptide predicted for SAR1395 by SignalP 2.0 HMM (Signal peptide probabilty 0.945) with cleavage site probability 0.847 between residues 34 and 35; signal peptide 282458006408 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 282458006409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458006410 dimer interface [polypeptide binding]; other site 282458006411 conserved gate region; other site 282458006412 putative PBP binding loops; other site 282458006413 ABC-ATPase subunit interface; other site 282458006414 6 probable transmembrane helices predicted for SAR1395 by TMHMM2.0 at aa 7-29, 104-126, 139-161, 171-193, 228-250 and 278-300 282458006415 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 15.40, E-value 0.029 282458006416 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282458006417 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 282458006418 3 probable transmembrane helices predicted for SAR1396 by TMHMM2.0 at aa 10-29, 31-50 and 60-82 282458006419 oligoendopeptidase F; Region: pepF; TIGR00181 282458006420 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 282458006421 active site 282458006422 Zn binding site [ion binding]; other site 282458006423 Pfam match to entry PF01432 Peptidase_M3, Peptidase M3, score 43.70, E-value 5.8e-10 282458006424 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282458006425 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 282458006426 PhoU domain; Region: PhoU; pfam01895 282458006427 PhoU domain; Region: PhoU; pfam01895 282458006428 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 282458006429 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 282458006430 Walker A/P-loop; other site 282458006431 ATP binding site [chemical binding]; other site 282458006432 Q-loop/lid; other site 282458006433 ABC transporter signature motif; other site 282458006434 Walker B; other site 282458006435 D-loop; other site 282458006436 H-loop/switch region; other site 282458006437 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 215.20, E-value 9.6e-61 282458006438 PS00211 ABC transporters family signature. 282458006439 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006440 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 282458006441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458006442 dimer interface [polypeptide binding]; other site 282458006443 conserved gate region; other site 282458006444 putative PBP binding loops; other site 282458006445 ABC-ATPase subunit interface; other site 282458006446 6 probable transmembrane helices predicted for SAR1400 by TMHMM2.0 at aa 33-55, 86-108, 128-150, 155-177, 207-229 and 275-297 282458006447 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 77.50, E-value 2.7e-19 282458006448 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282458006449 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 282458006450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458006451 dimer interface [polypeptide binding]; other site 282458006452 conserved gate region; other site 282458006453 ABC-ATPase subunit interface; other site 282458006454 6 probable transmembrane helices predicted for SAR1401 by TMHMM2.0 at aa 25-47, 79-111, 124-146, 161-180, 209-231 and 275-297 282458006455 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 55.50, E-value 1.2e-12 282458006456 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282458006457 Signal peptide predicted for SAR1402 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.185 between residues 29 and 30; signal peptide 282458006458 phosphate binding protein; Region: ptsS_2; TIGR02136 282458006459 Pfam match to entry PF01449 PstS, Phosphate-binding protein, score 233.10, E-value 4e-66 282458006460 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458006461 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 282458006462 S1 domain; Region: S1_2; pfam13509 282458006463 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 282458006464 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282458006465 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282458006466 ABC transporter; Region: ABC_tran_2; pfam12848 282458006467 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282458006468 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 134.60, E-value 1.7e-36 282458006469 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006470 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 69.20, E-value 8.9e-17 282458006471 aspartate kinase; Reviewed; Region: PRK06635 282458006472 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 282458006473 putative nucleotide binding site [chemical binding]; other site 282458006474 putative catalytic residues [active] 282458006475 putative Mg ion binding site [ion binding]; other site 282458006476 putative aspartate binding site [chemical binding]; other site 282458006477 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 282458006478 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 282458006479 Pfam match to entry PF00696 aakinase, Amino acid kinase, score 166.80, E-value 3.6e-46 282458006480 PS00324 Aspartokinase signature. 282458006481 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 282458006482 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 282458006483 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 282458006484 Pfam match to entry PF01118 Semialdhyde_dh, Semialdehyde dehydrogenase, NAD binding domain, score 128.50, E-value 1.8e-40 282458006485 Pfam match to entry PF02774 Semialdhyde_dhC, Semialdehyde dehydrogenase, dimerisation domain, score 190.10, E-value 3.5e-53 282458006486 Pfam match to entry PF02800 gpdh_C, Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, score 16.60, E-value 0.002 282458006487 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 282458006488 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 282458006489 dimer interface [polypeptide binding]; other site 282458006490 active site 282458006491 catalytic residue [active] 282458006492 Pfam match to entry PF00701 DHDPS, Dihydrodipicolinate synthetase, score 285.60, E-value 6.3e-82 282458006493 PS00666 Dihydrodipicolinate synthetase signature 2. 282458006494 dihydrodipicolinate reductase; Provisional; Region: PRK00048 282458006495 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 282458006496 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 282458006497 Pfam match to entry PF01113 DapB, Dihydrodipicolinate reductase, score 54.30, E-value 2.6e-12 282458006498 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 282458006499 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 282458006500 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 282458006501 active site 282458006502 trimer interface [polypeptide binding]; other site 282458006503 substrate binding site [chemical binding]; other site 282458006504 CoA binding site [chemical binding]; other site 282458006505 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 10.80, E-value 33 282458006506 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 15.70, E-value 1.1 282458006507 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 9.90, E-value 43 282458006508 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 16.70, E-value 0.54 282458006509 PS00101 Hexapeptide-repeat containing-transferases signature. 282458006510 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 10.40, E-value 37 282458006511 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 282458006512 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 282458006513 metal binding site [ion binding]; metal-binding site 282458006514 dimer interface [polypeptide binding]; other site 282458006515 Pfam match to entry PF01546 Peptidase_M20, Peptidase M20/M25/M40, score 77.00, E-value 3.7e-21 282458006516 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 282458006517 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 282458006518 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 282458006519 catalytic residue [active] 282458006520 Pfam match to entry PF00842 Ala_racemase, Alanine racemase, score 6.20, E-value 1 282458006521 Pfam match to entry PF00842 Ala_racemase, Alanine racemase, score 31.60, E-value 1.1e-07 282458006522 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 282458006523 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 282458006524 active site 282458006525 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 282458006526 substrate binding site [chemical binding]; other site 282458006527 catalytic residues [active] 282458006528 dimer interface [polypeptide binding]; other site 282458006529 Pfam match to entry PF02784 Orn_Arg_deC_N, Pyridoxal-dependent decarboxylase, pyridoxal binding domain, score 252.00, E-value 1.1e-73 282458006530 Pfam match to entry PF00278 Orn_DAP_Arg_deC, Pyridoxal-dependent decarboxylase, C-terminal sheet domain, score 109.50, E-value 8.7e-30 282458006531 Signal peptide predicted for SAR1413 by SignalP 2.0 HMM (Signal peptide probabilty 0.845) with cleavage site probability 0.318 between residues 29 and 30; signal peptide 282458006532 4 probable transmembrane helices predicted for SAR1413 by TMHMM2.0 at aa 3-21, 25-47, 54-76 and 108-125 282458006533 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 282458006534 DNA-binding site [nucleotide binding]; DNA binding site 282458006535 RNA-binding motif; other site 282458006536 Pfam match to entry PF00313 CSD, 'Cold-shock' DNA-binding domain, score 146.70, E-value 4.2e-40 282458006537 PS00352 'Cold-shock' DNA-binding domain signature. 282458006538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 282458006539 Pfam match to entry PF00708 Acylphosphatase, Acylphosphatase, score 27.60, E-value 3.6e-06 282458006540 acylphosphatase; Provisional; Region: PRK14431 282458006541 PS00150 Acylphosphatase signature 1. 282458006542 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 282458006543 Signal peptide predicted for SAR1417 by SignalP 2.0 HMM (Signal peptide probabilty 0.627) with cleavage site probability 0.258 between residues 34 and 35; signal peptide 282458006544 2 probable transmembrane helices predicted for SAR1417 by TMHMM2.0 at aa 7-29 and 33-51 282458006545 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 282458006546 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 282458006547 Signal peptide predicted for SAR1419 by SignalP 2.0 HMM (Signal peptide probabilty 0.960) with cleavage site probability 0.487 between residues 30 and 31; signal peptide 282458006548 12 probable transmembrane helices predicted for SAR1419 by TMHMM2.0 at aa 7-25, 35-57, 77-94, 109-131, 143-160, 193-215, 228-250, 292-314, 321-338, 348-370, 382-404 and 419-437 282458006549 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 282458006550 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 282458006551 metal ion-dependent adhesion site (MIDAS); other site 282458006552 MoxR-like ATPases [General function prediction only]; Region: COG0714 282458006553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458006554 Walker A motif; other site 282458006555 ATP binding site [chemical binding]; other site 282458006556 Walker B motif; other site 282458006557 arginine finger; other site 282458006558 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006559 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 282458006560 active site 282458006561 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 282458006562 active site 282458006563 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 282458006564 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 282458006565 E3 interaction surface; other site 282458006566 lipoyl attachment site [posttranslational modification]; other site 282458006567 e3 binding domain; Region: E3_binding; pfam02817 282458006568 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 282458006569 Pfam match to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain), score 295.10, E-value 8.4e-85 282458006570 Pfam match to entry PF02817 e3_binding, e3 binding domain, score 20.00, E-value 0.0051 282458006571 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme, score 99.30, E-value 7.6e-26 282458006572 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 282458006573 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 282458006574 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 282458006575 TPP-binding site [chemical binding]; other site 282458006576 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 282458006577 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 282458006578 Pfam match to entry PF02779 transket_pyr, Transketolase, central domain, score 184.10, E-value 2.2e-51 282458006579 Pfam match to entry PF00676 E1_dehydrog, Dehydrogenase E1 component, score 187.90, E-value 1.7e-52 282458006580 Signal peptide predicted for SAR1426 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.387 between residues 39 and 40; signal peptide 282458006581 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 282458006582 HAMP domain; Region: HAMP; pfam00672 282458006583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282458006584 dimer interface [polypeptide binding]; other site 282458006585 phosphorylation site [posttranslational modification] 282458006586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458006587 ATP binding site [chemical binding]; other site 282458006588 Mg2+ binding site [ion binding]; other site 282458006589 G-X-G motif; other site 282458006590 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 126.50, E-value 4.9e-34 282458006591 Pfam match to entry PF00512 signal, His Kinase A (phosphoacceptor) domain, score 70.50, E-value 3.5e-17 282458006592 Pfam match to entry PF00672 HAMP, HAMP domain, score 36.40, E-value 6.4e-07 282458006593 2 probable transmembrane helices predicted for SAR1426 by TMHMM2.0 at aa 10-32 and 154-176 282458006594 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282458006595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458006596 active site 282458006597 phosphorylation site [posttranslational modification] 282458006598 intermolecular recognition site; other site 282458006599 dimerization interface [polypeptide binding]; other site 282458006600 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282458006601 DNA binding site [nucleotide binding] 282458006602 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 100.80, E-value 7.5e-29 282458006603 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 150.80, E-value 2.4e-41 282458006604 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 282458006605 Signal peptide predicted for SAR1429 by SignalP 2.0 HMM (Signal peptide probabilty 0.752) with cleavage site probability 0.331 between residues 30 and 31; signal peptide 282458006606 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 282458006607 active site 282458006608 Pfam match to entry PF01569 PAP2, PAP2 superfamily, score 112.10, E-value 1e-29 282458006609 6 probable transmembrane helices predicted for SAR1429 by TMHMM2.0 at aa 7-24, 58-77, 84-101, 121-143, 150-172 and 176-198 282458006610 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 282458006611 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 282458006612 active site 282458006613 homodimer interface [polypeptide binding]; other site 282458006614 Pfam match to entry PF00201 UDPGT, UDP-glucoronosyl and UDP-glucosyl transferase, score 16.90, E-value 0.0006 282458006615 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458006616 Coenzyme A binding pocket [chemical binding]; other site 282458006617 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 44.80, E-value 2e-09 282458006618 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 282458006619 C-terminal peptidase (prc); Region: prc; TIGR00225 282458006620 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 282458006621 protein binding site [polypeptide binding]; other site 282458006622 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 282458006623 Catalytic dyad [active] 282458006624 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 282458006625 Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF)., score 67.30, E-value 3.2e-16 282458006626 1 probable transmembrane helix predicted for SAR1432 by TMHMM2.0 at aa 39-61 282458006627 insertion sequence ISX 282458006628 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 282458006629 Helix-turn-helix domain; Region: HTH_38; pfam13936 282458006630 Integrase core domain; Region: rve; pfam00665 282458006631 Predicted helix-turn-helix motif with score 1647 (+4.80 SD) at aa 22-43, sequence YSLRSIARKLKRSVSTISREIS 282458006632 Pfam match to entry PF00665 rve, Integrase core domain, score 119.70, E-value 2.1e-33 282458006633 PS01043 Transposases, IS30 family, signature. 282458006634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 282458006635 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 282458006636 HPr interaction site; other site 282458006637 glycerol kinase (GK) interaction site [polypeptide binding]; other site 282458006638 active site 282458006639 phosphorylation site [posttranslational modification] 282458006640 Pfam match to entry PF00358 PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1, score 210.30, E-value 2.9e-59 282458006641 PS00371 PTS EIIA domains phosphorylation site signature 1. 282458006642 methionine sulfoxide reductase B; Provisional; Region: PRK00222 282458006643 SelR domain; Region: SelR; pfam01641 282458006644 Pfam match to entry PF01641 DUF25, Domain of unknown function DUF25, score 247.80, E-value 1.5e-70 282458006645 methionine sulfoxide reductase A; Provisional; Region: PRK13014 282458006646 Pfam match to entry PF01625 PMSR, Peptide methionine sulfoxide reductase, score 257.10, E-value 2.3e-73 282458006647 EDD domain protein, DegV family; Region: DegV; TIGR00762 282458006648 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 282458006649 Pfam match to entry PF02645 DUF194, Uncharacterized protein, DegV family COG1307, score 163.30, E-value 4.1e-45 282458006650 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 282458006651 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 282458006652 folate binding site [chemical binding]; other site 282458006653 NADP+ binding site [chemical binding]; other site 282458006654 Pfam match to entry PF00186 DiHfolate_red, Dihydrofolate reductase, score 221.00, E-value 1.7e-62 282458006655 PS00075 Dihydrofolate reductase signature. 282458006656 thymidylate synthase; Region: thym_sym; TIGR03284 282458006657 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 282458006658 dimerization interface [polypeptide binding]; other site 282458006659 active site 282458006660 Pfam match to entry PF00303 thymidylat_synt, Thymidylate synthase, score 605.30, E-value 3.5e-178 282458006661 PS00091 Thymidylate synthase active site. 282458006662 Disulphide isomerase; Region: Disulph_isomer; cl05813 282458006663 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 282458006664 Virulence factor; Region: Virulence_fact; pfam13769 282458006665 HEAT repeats; Region: HEAT_2; pfam13646 282458006666 HEAT repeat; Region: HEAT; pfam02985 282458006667 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 282458006668 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 282458006669 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 282458006670 7 probable transmembrane helices predicted for SAR1445 by TMHMM2.0 at aa 5-22, 29-46, 51-73, 86-108, 128-150, 170-192 and 196-218 282458006671 Pfam match to entry PF02592 DUF165, Uncharacterized ACR, YhhQ family COG1738, score 258.20, E-value 1.1e-73 282458006672 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 282458006673 RNA/DNA hybrid binding site [nucleotide binding]; other site 282458006674 active site 282458006675 Signal peptide predicted for SAR1447 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.970 between residues 39 and 40; signal peptide 282458006676 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282458006677 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 282458006678 GA module; Region: GA; smart00844 282458006679 GA module; Region: GA; smart00844 282458006680 GA module; Region: GA; smart00844 282458006681 GA module; Region: GA; smart00844 282458006682 GA module; Region: GA; smart00844 282458006683 GA module; Region: GA; smart00844 282458006684 GA module; Region: GA; smart00844 282458006685 GA module; Region: GA; smart00844 282458006686 GA module; Region: GA; smart00844 282458006687 GA module; Region: GA; smart00844 282458006688 GA module; Region: GA; smart00844 282458006689 GA module; Region: GA; smart00844 282458006690 GA module; Region: GA; smart00844 282458006691 GA module; Region: GA; smart00844 282458006692 GA module; Region: GA; smart00844 282458006693 GA module; Region: GA; smart00844 282458006694 GA module; Region: GA; smart00844 282458006695 GA module; Region: GA; pfam01468 282458006696 GA module; Region: GA; smart00844 282458006697 GA module; Region: GA; smart00844 282458006698 GA module; Region: GA; smart00844 282458006699 GA module; Region: GA; smart00844 282458006700 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 282458006701 GA module; Region: GA; smart00844 282458006702 GA module; Region: GA; smart00844 282458006703 GA module; Region: GA; smart00844 282458006704 GA module; Region: GA; smart00844 282458006705 GA module; Region: GA; smart00844 282458006706 GA module; Region: GA; smart00844 282458006707 GA module; Region: GA; smart00844 282458006708 GA module; Region: GA; pfam01468 282458006709 GA module; Region: GA; smart00844 282458006710 GA module; Region: GA; smart00844 282458006711 GA module; Region: GA; smart00844 282458006712 GA module; Region: GA; smart00844 282458006713 GA module; Region: GA; smart00844 282458006714 GA module; Region: GA; smart00844 282458006715 chromosome segregation protein; Provisional; Region: PRK02224 282458006716 GA module; Region: GA; smart00844 282458006717 GA module; Region: GA; smart00844 282458006718 GA module; Region: GA; pfam01468 282458006719 GA module; Region: GA; smart00844 282458006720 GA module; Region: GA; smart00844 282458006721 GA module; Region: GA; smart00844 282458006722 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458006723 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458006724 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458006725 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458006726 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458006727 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458006728 1 probable transmembrane helix predicted for SAR1447 by TMHMM2.0 at aa 10551-10573 282458006729 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 282458006730 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -97.30, E-value 0.0026 282458006731 14 probable transmembrane helices predicted for SAR1448 by TMHMM2.0 at aa 13-35, 50-72, 85-107, 111-133, 140-162, 166-185, 206-223, 228-250, 271-293, 303-322, 334-353, 357-379, 400-422 and 432-454 282458006732 Signal peptide predicted for SAR1449 by SignalP 2.0 HMM (Signal peptide probabilty 0.758) with cleavage site probability 0.388 between residues 32 and 33; signal peptide 282458006733 Amino acid permease; Region: AA_permease_2; pfam13520 282458006734 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score -94.10, E-value 4.1e-09 282458006735 12 probable transmembrane helices predicted for SAR1449 by TMHMM2.0 at aa 12-34, 49-71, 91-113, 123-145, 152-174, 194-216, 229-251, 282-299, 327-349, 353-375, 388-407 and 411-433 282458006736 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 282458006737 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 282458006738 tetramer interface [polypeptide binding]; other site 282458006739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458006740 catalytic residue [active] 282458006741 Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme, score 288.10, E-value 1.1e-82 282458006742 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 282458006743 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 282458006744 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 282458006745 hexamer interface [polypeptide binding]; other site 282458006746 ligand binding site [chemical binding]; other site 282458006747 putative active site [active] 282458006748 NAD(P) binding site [chemical binding]; other site 282458006749 Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase, score 394.70, E-value 9e-115 282458006750 5'-3' exonuclease; Region: 53EXOc; smart00475 282458006751 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 282458006752 active site 282458006753 metal binding site 1 [ion binding]; metal-binding site 282458006754 putative 5' ssDNA interaction site; other site 282458006755 metal binding site 3; metal-binding site 282458006756 metal binding site 2 [ion binding]; metal-binding site 282458006757 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 282458006758 putative DNA binding site [nucleotide binding]; other site 282458006759 putative metal binding site [ion binding]; other site 282458006760 Pfam match to entry PF01367 5_3_exonuclease, 5'-3' exonuclease, C-terminal SAM fold, score 131.30, E-value 1.7e-38 282458006761 Pfam match to entry PF02739 5_3_exonuc_N, 5'-3' exonuclease, N-terminal resolvase-like domain, score 241.60, E-value 1.1e-68 282458006762 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 282458006763 Dynamin family; Region: Dynamin_N; pfam00350 282458006764 G1 box; other site 282458006765 GTP/Mg2+ binding site [chemical binding]; other site 282458006766 G2 box; other site 282458006767 Switch I region; other site 282458006768 G3 box; other site 282458006769 Switch II region; other site 282458006770 G4 box; other site 282458006771 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 282458006772 Dynamin family; Region: Dynamin_N; pfam00350 282458006773 G1 box; other site 282458006774 GTP/Mg2+ binding site [chemical binding]; other site 282458006775 G2 box; other site 282458006776 Switch I region; other site 282458006777 G3 box; other site 282458006778 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 282458006779 G3 box; other site 282458006780 Switch II region; other site 282458006781 GTP/Mg2+ binding site [chemical binding]; other site 282458006782 G4 box; other site 282458006783 G5 box; other site 282458006784 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006785 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006786 Similar to Pseudomonas putida membrane protein, PP4839 SWALL:Q88DI6 (EMBL:AE016792) (455 aa) fasta scores: E(): 1e-30, 27.27% id in 462 aa. Highly similar to Staphylococcus aureus hypothetical protein MW1331 SWALL:Q8NWQ0 (EMBL:AP004826) (446 aa) fasta scores: E(): 6.3e-170, 98.2% id in 446 aa. CDS contains a frameshift after codon 401. Frameshift occurs at a poly A octamer; membrane protein (pseudogene) 282458006787 5 probable transmembrane helices predicted for SAR1454 by TMHMM2.0 at aa 15-37, 139-161, 181-203, 366-387 and 407-438 282458006788 Signal peptide predicted for SAR1455 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.399 between residues 29 and 30; signal peptide 282458006789 Cobalt transport protein component CbiN; Region: CbiN; cl00842 282458006790 1 probable transmembrane helix predicted for SAR1455 by TMHMM2.0 at aa 5-27 282458006791 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 282458006792 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 282458006793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 282458006794 Pfam match to entry PF01170 UPF0020, Uncharacterized protein family UPF0020, score 233.20, E-value 3.7e-66 282458006795 PS00092 N-6 Adenine-specific DNA methylases signature. 282458006796 PS01261 Uncharacterized protein family UPF0020 signature. 282458006797 cell division protein GpsB; Provisional; Region: PRK14127 282458006798 DivIVA domain; Region: DivI1A_domain; TIGR03544 282458006799 hypothetical protein; Provisional; Region: PRK13660 282458006800 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 282458006801 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 282458006802 Signal peptide predicted for SAR1461 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.664 between residues 60 and 61; signal peptide 282458006803 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 282458006804 Transglycosylase; Region: Transgly; pfam00912 282458006805 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 282458006806 1 probable transmembrane helix predicted for SAR1461 by TMHMM2.0 at aa 35-57 282458006807 Pfam match to entry PF00912 Transglycosyl, Transglycosylase, score 352.40, E-value 5e-102 282458006808 Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain, score 64.00, E-value 3.2e-15 282458006809 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 282458006810 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 282458006811 minor groove reading motif; other site 282458006812 helix-hairpin-helix signature motif; other site 282458006813 substrate binding pocket [chemical binding]; other site 282458006814 active site 282458006815 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 282458006816 PS00764 Endonuclease III iron-sulfur binding region signature. 282458006817 Pfam match to entry PF00730 HhH-GPD, HhH-GPD superfamily base excision DNA repair protein, score 247.10, E-value 2.4e-70 282458006818 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 282458006819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 282458006820 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 282458006821 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 282458006822 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 282458006823 putative dimer interface [polypeptide binding]; other site 282458006824 putative anticodon binding site; other site 282458006825 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 282458006826 homodimer interface [polypeptide binding]; other site 282458006827 motif 1; other site 282458006828 motif 2; other site 282458006829 active site 282458006830 motif 3; other site 282458006831 Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N), score 292.30, E-value 6.1e-84 282458006832 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 282458006833 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain, score 65.80, E-value 9.5e-16 282458006834 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 282458006835 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 282458006836 active site 282458006837 catalytic site [active] 282458006838 substrate binding site [chemical binding]; other site 282458006839 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 282458006840 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 282458006841 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006842 Pfam match to entry PF00929 Exonuclease, Exonuclease, score 99.60, E-value 6.3e-26 282458006843 Biotin operon repressor [Transcription]; Region: BirA; COG1654 282458006844 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 282458006845 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 282458006846 Pfam match to entry PF01317 BPL, Biotin protein ligase catalytic domain, score 154.60, E-value 1.8e-42 282458006847 Predicted helix-turn-helix motif with score 1321 (+3.69 SD) at aa 20-41, sequence ISGQSIAESLNISRTAVKKVID 282458006848 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 282458006849 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 282458006850 active site 282458006851 NTP binding site [chemical binding]; other site 282458006852 metal binding triad [ion binding]; metal-binding site 282458006853 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 282458006854 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 282458006855 Pfam match to entry PF01743 PolyA_pol, Poly A polymerase, score 165.90, E-value 6.9e-46 282458006856 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 282458006857 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 282458006858 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 144.50, E-value 1.8e-39 282458006859 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 282458006860 homodimer interface [polypeptide binding]; other site 282458006861 metal binding site [ion binding]; metal-binding site 282458006862 Signal peptide predicted for SAR1471 by SignalP 2.0 HMM (Signal peptide probabilty 0.678) with cleavage site probability 0.371 between residues 21 and 22; signal peptide 282458006863 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 282458006864 4 probable transmembrane helices predicted for SAR1471 by TMHMM2.0 at aa 4-21, 119-141, 151-173 and 202-224 282458006865 PS00107 Protein kinases ATP-binding region signature. 282458006866 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282458006867 Predicted membrane protein [Function unknown]; Region: COG4347 282458006868 6 probable transmembrane helices predicted for SAR1472 by TMHMM2.0 at aa 13-35, 50-69, 78-100, 105-127, 134-156 and 166-188 282458006869 Uncharacterized conserved protein [Function unknown]; Region: COG5582 282458006870 UPF0302 domain; Region: UPF0302; pfam08864 282458006871 A short protein domain of unknown function; Region: IDEAL; smart00914 282458006872 TPR repeat; Region: TPR_11; pfam13414 282458006873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 282458006874 binding surface 282458006875 TPR motif; other site 282458006876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 282458006877 TPR motif; other site 282458006878 binding surface 282458006879 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 282458006880 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 282458006881 hinge; other site 282458006882 active site 282458006883 Pfam match to entry PF00275 EPSP_syntase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase), score 580.10, E-value 1.4e-170 282458006884 PS00104 EPSP synthase signature 1. 282458006885 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 282458006886 active site 282458006887 NAD binding site [chemical binding]; other site 282458006888 metal binding site [ion binding]; metal-binding site 282458006889 Pfam match to entry PF01761 DHQ_synthase, 3-dehydroquinate synthase, score 250.50, E-value 2.4e-71 282458006890 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 282458006891 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 282458006892 Tetramer interface [polypeptide binding]; other site 282458006893 active site 282458006894 FMN-binding site [chemical binding]; other site 282458006895 Pfam match to entry PF01264 Chorismate_synt, Chorismate synthase, score 786.70, E-value 1.4e-239 282458006896 PS00789 Chorismate synthase signature 3. 282458006897 PS00788 Chorismate synthase signature 2. 282458006898 PS00787 Chorismate synthase signature 1. 282458006899 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 282458006900 active site 282458006901 multimer interface [polypeptide binding]; other site 282458006902 Pfam match to entry PF00334 NDK, Nucleoside diphosphate kinases, score 326.50, E-value 3.1e-94 282458006903 PS00469 Nucleoside diphosphate kinases active site. 282458006904 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 282458006905 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 282458006906 substrate binding pocket [chemical binding]; other site 282458006907 chain length determination region; other site 282458006908 substrate-Mg2+ binding site; other site 282458006909 catalytic residues [active] 282458006910 aspartate-rich region 1; other site 282458006911 active site lid residues [active] 282458006912 aspartate-rich region 2; other site 282458006913 Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetase, score 266.90, E-value 2.7e-76 282458006914 PS00444 Polyprenyl synthetases signature 2. 282458006915 PS00723 Polyprenyl synthetases signature 1. 282458006916 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 282458006917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458006918 S-adenosylmethionine binding site [chemical binding]; other site 282458006919 Pfam match to entry PF01209 Ubie_methyltran, ubiE/COQ5 methyltransferase, score 409.00, E-value 4.6e-119 282458006920 PS01184 ubiE/COQ5 methyltransferase signature 2. 282458006921 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 282458006922 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 282458006923 IHF dimer interface [polypeptide binding]; other site 282458006924 IHF - DNA interface [nucleotide binding]; other site 282458006925 Pfam match to entry PF00216 Bac_DNA_binding, Bacterial DNA-binding protein, score 200.00, E-value 3.2e-56 282458006926 PS00045 Bacterial histone-like DNA-binding proteins signature. 282458006927 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 282458006928 Signal peptide predicted for SAR1483 by SignalP 2.0 HMM (Signal peptide probabilty 0.866) with cleavage site probability 0.757 between residues 21 and 22; signal peptide 282458006929 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 282458006930 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 282458006931 Pfam match to entry PF01210 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase, score 481.00, E-value 9.7e-141 282458006932 GTP-binding protein Der; Reviewed; Region: PRK00093 282458006933 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 282458006934 G1 box; other site 282458006935 GTP/Mg2+ binding site [chemical binding]; other site 282458006936 Switch I region; other site 282458006937 G2 box; other site 282458006938 Switch II region; other site 282458006939 G3 box; other site 282458006940 G4 box; other site 282458006941 G5 box; other site 282458006942 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 282458006943 G1 box; other site 282458006944 GTP/Mg2+ binding site [chemical binding]; other site 282458006945 Switch I region; other site 282458006946 G2 box; other site 282458006947 G3 box; other site 282458006948 Switch II region; other site 282458006949 G4 box; other site 282458006950 G5 box; other site 282458006951 Pfam match to entry PF01926 MMR_HSR1, GTPase of unknown function, score 215.90, E-value 6.2e-61 282458006952 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006953 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006954 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 282458006955 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 282458006956 RNA binding site [nucleotide binding]; other site 282458006957 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 282458006958 RNA binding site [nucleotide binding]; other site 282458006959 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 282458006960 RNA binding site [nucleotide binding]; other site 282458006961 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 282458006962 RNA binding site [nucleotide binding]; other site 282458006963 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 90.10, E-value 2.6e-23 282458006964 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 105.10, E-value 1.3e-27 282458006965 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 63.80, E-value 4.9e-16 282458006966 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 57.30, E-value 3e-14 282458006967 cytidylate kinase; Provisional; Region: cmk; PRK00023 282458006968 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 282458006969 CMP-binding site; other site 282458006970 The sites determining sugar specificity; other site 282458006971 Pfam match to entry PF02224 Cytidylate_kin, Cytidylate kinase, score 230.40, E-value 2.6e-65 282458006972 PS00017 ATP/GTP-binding site motif A (P-loop). 282458006973 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 282458006974 active site 282458006975 homotetramer interface [polypeptide binding]; other site 282458006976 homodimer interface [polypeptide binding]; other site 282458006977 PS00144 Asparaginase / glutaminase active site signature 1. 282458006978 Pfam match to entry PF00710 Asparaginase, Asparaginase, score 229.40, E-value 5.2e-65 282458006979 PS00917 Asparaginase / glutaminase active site signature 2. 282458006980 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 282458006981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 282458006982 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282458006983 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 39.10, E-value 5.7e-08 282458006984 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282458006985 Pfam match to entry PF01476 LysM, LysM domain, score 28.00, E-value 0.00022 282458006986 1 probable transmembrane helix predicted for SAR1489 by TMHMM2.0 at aa 320-342 282458006987 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 282458006988 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282458006989 ATP binding site [chemical binding]; other site 282458006990 putative Mg++ binding site [ion binding]; other site 282458006991 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282458006992 nucleotide binding region [chemical binding]; other site 282458006993 ATP-binding site [chemical binding]; other site 282458006994 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 97.80, E-value 2.2e-25 282458006995 Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase, score 108.70, E-value 1.8e-33 282458006996 PS00690 DEAH-box subfamily ATP-dependent helicases signature. 282458006997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 282458006998 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 282458006999 Predicted membrane protein [Function unknown]; Region: COG3601 282458007000 Signal peptide predicted for SAR1493 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.428 between residues 39 and 40; signal peptide 282458007001 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 282458007002 5 probable transmembrane helices predicted for SAR1493 by TMHMM2.0 at aa 7-29, 44-66, 78-95, 105-127 and 147-169 282458007003 Signal peptide predicted for SAR1494 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.455 between residues 26 and 27; signal peptide 282458007004 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 282458007005 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458007006 Signal peptide predicted for SAR1495 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.531 between residues 26 and 27; signal peptide 282458007007 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 282458007008 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458007009 Similar to Staphylococcus aureus hypothetical protein SAV1489 SWALL:Q99U01 (EMBL:AP003362) (720 aa) fasta scores: E(): 6.1e-130, 53.36% id in 729 aa. CDS contains a frameshift after codon 281. CDS is also disrupted by the insertion of a prophage phiSa2(252) after codon 667;hypothetical protein (pseudogene) 282458007010 phiSLT and phi PVL like phage 282458007011 CHAP domain; Region: CHAP; pfam05257 282458007012 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 282458007013 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 282458007014 active site 282458007015 metal binding site [ion binding]; metal-binding site 282458007016 Bacterial SH3 domain; Region: SH3_5; pfam08460 282458007017 holin, SPP1 family; Region: holin_SPP1; TIGR01592 282458007018 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 282458007019 1 probable transmembrane helix predicted for SAR1499 by TMHMM2.0 at aa 75-97 282458007020 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 282458007021 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 282458007022 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 282458007023 PS00340 Growth factor and cytokines receptors family signature 2. 282458007024 hypothetical protein; Provisional; Region: PRK05926 282458007025 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 282458007026 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 282458007027 Phage tail protein; Region: Sipho_tail; pfam05709 282458007028 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 282458007029 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 282458007030 linker region; other site 282458007031 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 282458007032 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 282458007033 Peptidase family M23; Region: Peptidase_M23; pfam01551 282458007034 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 282458007035 N-acetyl-D-glucosamine binding site [chemical binding]; other site 282458007036 catalytic residue [active] 282458007037 Pfam match to entry PF01551 Peptidase_M37, Peptidase M23/M37, score 66.10, E-value 7.3e-16 282458007038 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007039 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 282458007040 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 282458007041 Pfam match to entry PF02368 Big_2, Bacterial Ig-like domain (group 2), score 35.40, E-value 1.3e-06 282458007042 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 282458007043 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 282458007044 oligomerization interface [polypeptide binding]; other site 282458007045 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 282458007046 Phage capsid family; Region: Phage_capsid; pfam05065 282458007047 Clp protease; Region: CLP_protease; pfam00574 282458007048 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 282458007049 oligomer interface [polypeptide binding]; other site 282458007050 active site residues [active] 282458007051 Pfam match to entry PF00574 CLP_protease, Clp protease, score -6.00, E-value 5.3e-07 282458007052 1 probable transmembrane helix predicted for SAR1517 by TMHMM2.0 at aa 82-104 282458007053 Phage-related protein [Function unknown]; Region: COG4695; cl01923 282458007054 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 282458007055 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 282458007056 Phage terminase, small subunit; Region: Terminase_4; pfam05119 282458007057 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 282458007058 HNH endonuclease; Region: HNH; pfam01844 282458007059 active site 282458007060 Pfam match to entry PF01844 HNH, HNH endonuclease, score 21.60, E-value 0.0082 282458007061 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 282458007062 Predicted helix-turn-helix motif with score 1252 (+3.45 SD) at aa 111-132, sequence LKIEQIGDACHMHRNTVTTIRK 282458007063 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 282458007064 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282458007065 ATP binding site [chemical binding]; other site 282458007066 putative Mg++ binding site [ion binding]; other site 282458007067 helicase superfamily c-terminal domain; Region: HELICc; smart00490 282458007068 Pfam match to entry PF00176 SNF2_N, SNF2 and others N-terminal domain, score 21.40, E-value 6.7e-05 282458007069 VRR-NUC domain; Region: VRR_NUC; pfam08774 282458007070 Virulence-associated protein E; Region: VirE; pfam05272 282458007071 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007072 Signal peptide predicted for SAR1526 by SignalP 2.0 HMM (Signal peptide probabilty 0.704) with cleavage site probability 0.543 between residues 23 and 24; signal peptide 282458007073 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 282458007074 1 probable transmembrane helix predicted for SAR1526 by TMHMM2.0 at aa 4-21 282458007075 similar to hypothetical protein 282458007076 1 probable transmembrane helix predicted for SAR1526a by TMHMM2.0 at aa 2-20 282458007077 Transcriptional activator RinB; Region: RinB; pfam06116 282458007078 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 282458007079 dUTPase; Region: dUTPase_2; pfam08761 282458007080 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 282458007081 active site 282458007082 homodimer interface [polypeptide binding]; other site 282458007083 metal binding site [ion binding]; metal-binding site 282458007084 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 282458007085 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 282458007086 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007087 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 282458007088 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 282458007089 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 282458007090 Predicted helix-turn-helix motif with score 1491 (+4.27 SD) at aa 16-37, sequence MTLREVSEKYHISPELLRYRYK 282458007091 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 282458007092 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 282458007093 active site 282458007094 DNA binding site [nucleotide binding] 282458007095 catalytic site [active] 282458007096 Pfam match to entry PF00476 DNA_pol_A, DNA polymerase A, score -148.90, E-value 0.0018 282458007097 PS00447 DNA polymerase A signature. 282458007098 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 282458007099 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 282458007100 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 282458007101 Signal peptide predicted for SAR1546 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.716 between residues 38 and 39; signal peptide 282458007102 1 probable transmembrane helix predicted for SAR1546 by TMHMM2.0 at aa 7-29 282458007103 Homeodomain-like domain; Region: HTH_23; pfam13384 282458007104 Predicted helix-turn-helix motif with score 2106 (+6.36 SD) at aa 26-47, sequence ATPTQIHQLFGVCRSTVYNWLK 282458007105 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 282458007106 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 282458007107 Protein of unknown function (DUF739); Region: DUF739; pfam05339 282458007108 Predicted helix-turn-helix motif with score 1218 (+3.34 SD) at aa 25-46, sequence GNRYAFAYAIGLSERSLSLKLN 282458007109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282458007110 non-specific DNA binding site [nucleotide binding]; other site 282458007111 salt bridge; other site 282458007112 sequence-specific DNA binding site [nucleotide binding]; other site 282458007113 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 28.40, E-value 0.00016 282458007114 Domain of unknown function (DUF955); Region: DUF955; cl01076 282458007115 Signal peptide predicted for SAR1558 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.610 between residues 22 and 23; signal peptide 282458007116 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458007117 3 probable transmembrane helices predicted for SAR1561 by TMHMM2.0 at aa 2-21, 36-58 and 71-93 282458007118 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 282458007119 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 282458007120 Int/Topo IB signature motif; other site 282458007121 Pfam match to entry PF00589 Phage_integrase, Phage integrase, score 154.50, E-value 1.8e-42 282458007122 No significant database matches. Similar to SAR1494, 67% identity in 204 aa overlap, and to SAR1495, 64% identity in 193 aa overlap. Contains a frameshift after codon 232; lipoprotein (pseudogene) 282458007123 Signal peptide predicted for SAR1565 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.512 between residues 26 and 27 282458007124 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458007125 Signal peptide predicted for SAR1567 by SignalP 2.0 HMM (Signal peptide probabilty 0.938) with cleavage site probability 0.357 between residues 51 and 52; signal peptide 282458007126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 282458007127 dimerization interface [polypeptide binding]; other site 282458007128 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 282458007129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282458007130 dimer interface [polypeptide binding]; other site 282458007131 phosphorylation site [posttranslational modification] 282458007132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458007133 ATP binding site [chemical binding]; other site 282458007134 Mg2+ binding site [ion binding]; other site 282458007135 G-X-G motif; other site 282458007136 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 157.00, E-value 3.2e-43 282458007137 Pfam match to entry PF00512 signal, His Kinase A (phosphoacceptor) domain, score 80.10, E-value 4.4e-20 282458007138 Pfam match to entry PF00672 HAMP, HAMP domain, score 69.80, E-value 5.7e-17 282458007139 2 probable transmembrane helices predicted for SAR1567 by TMHMM2.0 at aa 15-37 and 178-200 282458007140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282458007141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458007142 active site 282458007143 phosphorylation site [posttranslational modification] 282458007144 intermolecular recognition site; other site 282458007145 dimerization interface [polypeptide binding]; other site 282458007146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282458007147 DNA binding site [nucleotide binding] 282458007148 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 112.80, E-value 1.9e-32 282458007149 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 139.40, E-value 6.5e-38 282458007150 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 282458007151 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 282458007152 RNA binding surface [nucleotide binding]; other site 282458007153 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 282458007154 active site 282458007155 Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase, score 86.80, E-value 4.3e-22 282458007156 PS01149 Rsu family of pseudouridine synthase signature. 282458007157 Pfam match to entry PF01479 S4, S4 domain, score 54.60, E-value 2.1e-12 282458007158 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 282458007159 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 282458007160 Pfam match to entry PF02616 DUF173, Uncharacterized ACR, COG1354, score 113.10, E-value 5.3e-30 282458007161 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 282458007162 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 282458007163 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 282458007164 active site 282458007165 Int/Topo IB signature motif; other site 282458007166 Pfam match to entry PF00589 Phage_integrase, Phage integrase, score 216.90, E-value 3e-61 282458007167 Pfam match to entry PF02899 Phage_integr_N, Phage integrase, N-terminal SAM-like domain, score 127.40, E-value 2.6e-34 282458007168 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 282458007169 metal binding site 2 [ion binding]; metal-binding site 282458007170 putative DNA binding helix; other site 282458007171 metal binding site 1 [ion binding]; metal-binding site 282458007172 dimer interface [polypeptide binding]; other site 282458007173 structural Zn2+ binding site [ion binding]; other site 282458007174 Pfam match to entry PF01475 FUR, Ferric uptake regulator family, score 188.90, E-value 7.8e-53 282458007175 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 282458007176 dimer interface [polypeptide binding]; other site 282458007177 ADP-ribose binding site [chemical binding]; other site 282458007178 active site 282458007179 nudix motif; other site 282458007180 metal binding site [ion binding]; metal-binding site 282458007181 Pfam match to entry PF00293 NUDIX, MutT-like domain, score 82.50, E-value 8.5e-21 282458007182 PS00893 mutT domain signature. 282458007183 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 282458007184 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 282458007185 active site 282458007186 catalytic tetrad [active] 282458007187 Pfam match to entry PF00248 aldo_ket_red, Aldo/keto reductase, score 85.20, E-value 1.3e-24 282458007188 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 282458007189 classical (c) SDRs; Region: SDR_c; cd05233 282458007190 NAD(P) binding site [chemical binding]; other site 282458007191 active site 282458007192 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 44.70, E-value 2e-09 282458007193 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 282458007194 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 282458007195 Pfam match to entry PF01089 P5CR, Delta 1-pyrroline-5-carboxylate reductase, score 167.70, E-value 1.9e-46 282458007196 ribonuclease Z; Region: RNase_Z; TIGR02651 282458007197 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 282458007198 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 282458007199 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 282458007200 Pfam match to entry PF00479 G6PD, Glucose-6-phosphate dehydrogenase, NAD binding domain, score 267.90, E-value 1.5e-98 282458007201 Pfam match to entry PF02781 G6PD_C, Glucose-6-phosphate dehydrogenase, C-terminal domain, score 450.60, E-value 1.4e-131 282458007202 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 282458007203 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 282458007204 PS00041 Bacterial regulatory proteins, araC family signature. 282458007205 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 51.40, E-value 2e-11 282458007206 Predicted helix-turn-helix motif with score 1399 (+3.95 SD) at aa 22-43, sequence FNLQELSDYVGLSPYHLDQSFK 282458007207 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 282458007208 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 282458007209 Ca binding site [ion binding]; other site 282458007210 active site 282458007211 catalytic site [active] 282458007212 Pfam match to entry PF00128 alpha-amylase, Alpha amylase, catalytic domain, score 384.60, E-value 1e-111 282458007213 Transcriptional regulators [Transcription]; Region: PurR; COG1609 282458007214 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 282458007215 DNA binding site [nucleotide binding] 282458007216 domain linker motif; other site 282458007217 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 282458007218 putative ligand binding site [chemical binding]; other site 282458007219 putative dimerization interface [polypeptide binding]; other site 282458007220 Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family., score 63.90, E-value 3.5e-15 282458007221 Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, score 45.20, E-value 2.4e-11 282458007222 Predicted helix-turn-helix motif with score 2503 (+7.71 SD) at aa 2-23, sequence VTIKDVALKAGVSPSTVSRVIK 282458007223 PS00356 Bacterial regulatory proteins, lacI family signature. 282458007224 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 282458007225 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 282458007226 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 18.40, E-value 0.0005 282458007227 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 282458007228 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 282458007229 substrate binding site [chemical binding]; other site 282458007230 ATP binding site [chemical binding]; other site 282458007231 Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 44.10, E-value 3.1e-09 282458007232 Similar to Streptoverticillium netropsis spectinomycin export protein for SpcT TR:Q9S1M2 (EMBL:U70376) (433 aa) fasta scores: E(): 1.6e-24, 26.972% id in 393 aa, and to Pyrococcus abyssi multidrug resistance protein PAB0724 TR:Q9UZQ7 (EMBL:AJ248286) (418 aa) fasta scores: E(): 4.5e-22, 29.584% id in 409 aa. Contains a frameshift after codon 32; membrane protein (pseudogene) 282458007233 10 probable transmembrane helices predicted for SAR1588 by TMHMM2.0 at aa 12-34, 47-69, 90-112, 167-189, 226-248, 258-280, 287-306, 311-333, 354-371 and 376-395 282458007234 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 282458007235 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 282458007236 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 282458007237 Pfam match to entry PF00393 6PGD, 6-phosphogluconate dehydrogenase, score 1042.80, E-value 0 282458007238 PS00461 6-phosphogluconate dehydrogenase signature. 282458007239 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 282458007240 peptidase T-like protein; Region: PepT-like; TIGR01883 282458007241 metal binding site [ion binding]; metal-binding site 282458007242 putative dimer interface [polypeptide binding]; other site 282458007243 Pfam match to entry PF01546 Peptidase_M20, Peptidase M20/M25/M40, score 125.50, E-value 4.5e-35 282458007244 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 282458007245 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 282458007246 Predicted membrane protein [Function unknown]; Region: COG4129 282458007247 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 282458007248 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 282458007249 4 probable transmembrane helices predicted for SAR1591 by TMHMM2.0 at aa 22-44, 57-79, 83-105 and 125-147 282458007250 Disulphide isomerase; Region: Disulph_isomer; pfam06491 282458007251 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 282458007252 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 282458007253 E3 interaction surface; other site 282458007254 lipoyl attachment site [posttranslational modification]; other site 282458007255 e3 binding domain; Region: E3_binding; pfam02817 282458007256 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 282458007257 Pfam match to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain), score 385.10, E-value 7.1e-112 282458007258 Pfam match to entry PF02817 e3_binding, e3 binding domain, score 45.40, E-value 1.2e-09 282458007259 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme, score 101.80, E-value 1.3e-26 282458007260 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 282458007261 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 282458007262 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 282458007263 alpha subunit interface [polypeptide binding]; other site 282458007264 TPP binding site [chemical binding]; other site 282458007265 heterodimer interface [polypeptide binding]; other site 282458007266 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 282458007267 Pfam match to entry PF02780 transketolase_C, Transketolase, C-terminal domain, score 170.00, E-value 3.9e-47 282458007268 Pfam match to entry PF02779 transket_pyr, Transketolase, central domain, score 244.20, E-value 1.9e-69 282458007269 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 282458007270 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 282458007271 tetramer interface [polypeptide binding]; other site 282458007272 TPP-binding site [chemical binding]; other site 282458007273 heterodimer interface [polypeptide binding]; other site 282458007274 phosphorylation loop region [posttranslational modification] 282458007275 Pfam match to entry PF00676 E1_dehydrog, Dehydrogenase E1 component, score 359.60, E-value 3.4e-104 282458007276 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 282458007277 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 282458007278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282458007279 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 282458007280 Pfam match to entry PF02852 pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 129.70, E-value 5.3e-35 282458007281 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 284.50, E-value 1.3e-81 282458007282 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 282458007283 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 282458007284 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 282458007285 Walker A/P-loop; other site 282458007286 ATP binding site [chemical binding]; other site 282458007287 Q-loop/lid; other site 282458007288 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 282458007289 ABC transporter signature motif; other site 282458007290 Walker B; other site 282458007291 D-loop; other site 282458007292 H-loop/switch region; other site 282458007293 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007294 arginine repressor; Provisional; Region: PRK04280 282458007295 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 282458007296 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 282458007297 Pfam match to entry PF02863 Arg_repressor_C, Arginine repressor, C-terminal domain, score 111.70, E-value 2.9e-30 282458007298 Pfam match to entry PF01316 Arg_repressor, Arginine repressor, DNA binding domain, score 111.00, E-value 2.3e-29 282458007299 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 282458007300 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 282458007301 substrate binding pocket [chemical binding]; other site 282458007302 chain length determination region; other site 282458007303 substrate-Mg2+ binding site; other site 282458007304 catalytic residues [active] 282458007305 aspartate-rich region 1; other site 282458007306 active site lid residues [active] 282458007307 aspartate-rich region 2; other site 282458007308 Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetase, score 305.30, E-value 7.2e-88 282458007309 PS00444 Polyprenyl synthetases signature 2. 282458007310 PS00723 Polyprenyl synthetases signature 1. 282458007311 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 282458007312 Pfam match to entry PF02609 Exonuc_VII_S, Exonuclease VII small subunit, score 32.20, E-value 1.2e-05 282458007313 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 282458007314 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 282458007315 generic binding surface II; other site 282458007316 generic binding surface I; other site 282458007317 Pfam match to entry PF02601 Exonuc_VII_L, Exonuclease VII, large subunit, score 207.40, E-value 2.2e-58 282458007318 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain, score 41.40, E-value 2.1e-08 282458007319 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 282458007320 putative RNA binding site [nucleotide binding]; other site 282458007321 Pfam match to entry PF01029 NusB, NusB family, score 110.60, E-value 3e-29 282458007322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 282458007323 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 282458007324 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 282458007325 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 282458007326 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 282458007327 Pfam match to entry PF02785 Biotin_carb_C, Biotin carboxylase C-terminal domain, score 200.50, E-value 2.7e-56 282458007328 Pfam match to entry PF02786 CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain, score 383.20, E-value 2.7e-111 282458007329 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 282458007330 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 282458007331 Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase L chain, N-terminal domain, score 160.00, E-value 4e-44 282458007332 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 282458007333 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 282458007334 carboxyltransferase (CT) interaction site; other site 282458007335 biotinylation site [posttranslational modification]; other site 282458007336 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme, score 114.80, E-value 1.7e-30 282458007337 elongation factor P; Validated; Region: PRK00529 282458007338 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 282458007339 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 282458007340 RNA binding site [nucleotide binding]; other site 282458007341 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 282458007342 RNA binding site [nucleotide binding]; other site 282458007343 Pfam match to entry PF01132 EFP, Elongation factor P (EF-P), score 392.20, E-value 5.2e-114 282458007344 PS01275 Elongation factor P signature. 282458007345 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 282458007346 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 282458007347 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 282458007348 active site 282458007349 Pfam match to entry PF00557 Peptidase_M24, metallopeptidase M24, score 255.00, E-value 1e-72 282458007350 PS00491 Aminopeptidase P and proline dipeptidase signature. 282458007351 Signal peptide predicted for SAR1608 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.484 between residues 27 and 28; signal peptide 282458007352 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 282458007353 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458007354 Signal peptide predicted for SAR1609 by SignalP 2.0 HMM (Signal peptide probabilty 0.826) with cleavage site probability 0.703 between residues 36 and 37; signal peptide 282458007355 2 probable transmembrane helices predicted for SAR1609 by TMHMM2.0 at aa 7-29 and 33-52 282458007356 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 282458007357 Pfam match to entry PF02539 Lipoate_A, Lipoate-protein ligase A, score 278.20, E-value 1.1e-79 282458007358 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 282458007359 active site residue [active] 282458007360 1 probable transmembrane helix predicted for SAR1611 by TMHMM2.0 at aa 4-21 282458007361 Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain, score 81.30, E-value 2e-20 282458007362 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 282458007363 tetramer interface [polypeptide binding]; other site 282458007364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458007365 catalytic residue [active] 282458007366 Pfam match to entry PF02347 GDC-P, Glycine cleavage system P-protein, score -300.50, E-value 0.02 282458007367 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 282458007368 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 282458007369 tetramer interface [polypeptide binding]; other site 282458007370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458007371 catalytic residue [active] 282458007372 Pfam match to entry PF02347 GDC-P, Glycine cleavage system P-protein, score 685.20, E-value 3.3e-202 282458007373 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 282458007374 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 282458007375 Pfam match to entry PF01571 GCV_T, Glycine cleavage T-protein (aminomethyl transferase), score 466.30, E-value 2.5e-136 282458007376 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 282458007377 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 282458007378 ADP binding site [chemical binding]; other site 282458007379 magnesium binding site [ion binding]; other site 282458007380 putative shikimate binding site; other site 282458007381 Pfam match to entry PF01202 SKI, Shikimate kinase, score 129.00, E-value 8.5e-35 282458007382 PS01128 Shikimate kinase signature. 282458007383 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007384 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 282458007385 1 probable transmembrane helix predicted for SAR1616 by TMHMM2.0 at aa 29-51 282458007386 Signal peptide predicted for SAR1617 by SignalP 2.0 HMM (Signal peptide probabilty 0.784) with cleavage site probability 0.405 between residues 48 and 49; signal peptide 282458007387 1 probable transmembrane helix predicted for SAR1617 by TMHMM2.0 at aa 10-32 282458007388 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 282458007389 Signal peptide predicted for SAR1618 by SignalP 2.0 HMM (Signal peptide probabilty 0.949) with cleavage site probability 0.593 between residues 33 and 34; signal peptide 282458007390 1 probable transmembrane helix predicted for SAR1618 by TMHMM2.0 at aa 7-29 282458007391 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 282458007392 Signal peptide predicted for SAR1619 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.508 between residues 36 and 37; signal peptide 282458007393 1 probable transmembrane helix predicted for SAR1619 by TMHMM2.0 at aa 10-32 282458007394 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 282458007395 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 282458007396 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 282458007397 Pfam match to entry PF00482 GSPII_F, Bacterial type II secretion system protein F domain, score 21.50, E-value 2.6e-05 282458007398 3 probable transmembrane helices predicted for SAR1620 by TMHMM2.0 at aa 123-145, 168-190 and 327-349 282458007399 Pfam match to entry PF00482 GSPII_F, Bacterial type II secretion system protein F domain, score 29.30, E-value 1.5e-07 282458007400 Type II/IV secretion system protein; Region: T2SE; pfam00437 282458007401 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 282458007402 Walker A motif; other site 282458007403 ATP binding site [chemical binding]; other site 282458007404 Walker B motif; other site 282458007405 Pfam match to entry PF00437 GSPII_E, Bacterial type II secretion system protein, score 253.60, E-value 1.1e-74 282458007406 PS00662 Bacterial type II secretion system protein E signature. 282458007407 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007408 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 282458007409 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 155.10, E-value 1.2e-42 282458007410 Uncharacterized conserved protein [Function unknown]; Region: COG0011 282458007411 Pfam match to entry PF01910 DUF77, Protein of unknown function DUF77, score 189.30, E-value 6e-53 282458007412 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 282458007413 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 282458007414 Pfam match to entry PF00480 ROK, ROK family, score 159.10, E-value 3e-46 282458007415 PS01125 ROK family signature. 282458007416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 282458007417 Rhomboid family; Region: Rhomboid; pfam01694 282458007418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 282458007419 binding surface 282458007420 TPR motif; other site 282458007421 Tetratricopeptide repeat; Region: TPR_16; pfam13432 282458007422 7 probable transmembrane helices predicted for SAR1626 by TMHMM2.0 at aa 156-178, 218-237, 242-259, 264-286, 293-312, 316-335 and 342-364 282458007423 Pfam match to entry PF01694 Rhomboid, Rhomboid family, score 125.70, E-value 8.8e-34 282458007424 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 282458007425 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 282458007426 Pfam match to entry PF01812 5-FTHF_cyc-lig, 5-formyltetrahydrofolate cyclo-ligase, score 142.80, E-value 6.2e-39 282458007427 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 282458007428 Pfam match to entry PF00471 Ribosomal_L33, Ribosomal protein L33, score 92.20, E-value 1e-23 282458007429 PS00582 Ribosomal protein L33 signature. 282458007430 Signal peptide predicted for SAR1629 by SignalP 2.0 HMM (Signal peptide probabilty 0.839) with cleavage site probability 0.756 between residues 48 and 49; signal peptide 282458007431 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 282458007432 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 282458007433 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 282458007434 Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain, score 252.00, E-value 7.9e-72 282458007435 1 probable transmembrane helix predicted for SAR1629 by TMHMM2.0 at aa 21-43 282458007436 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 282458007437 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 282458007438 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 282458007439 Pfam match to entry PF02777 sodfe_C, Iron/manganese superoxide dismutases, C-terminal domain, score 225.10, E-value 2.6e-68 282458007440 PS00088 Manganese and iron superoxide dismutases signature. 282458007441 Pfam match to entry PF00081 sodfe, Iron/manganese superoxide dismutases, alpha-hairpin domain, score 188.70, E-value 7.1e-56 282458007442 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 282458007443 metal binding site 2 [ion binding]; metal-binding site 282458007444 putative DNA binding helix; other site 282458007445 metal binding site 1 [ion binding]; metal-binding site 282458007446 dimer interface [polypeptide binding]; other site 282458007447 structural Zn2+ binding site [ion binding]; other site 282458007448 Pfam match to entry PF01475 FUR, Ferric uptake regulator family, score 162.00, E-value 1e-44 282458007449 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 282458007450 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282458007451 ABC-ATPase subunit interface; other site 282458007452 dimer interface [polypeptide binding]; other site 282458007453 putative PBP binding regions; other site 282458007454 Pfam match to entry PF00950 ABC-3, ABC 3 transport family, score 194.10, E-value 2.1e-54 282458007455 9 probable transmembrane helices predicted for SAR1632 by TMHMM2.0 at aa 10-32, 39-61, 66-85, 98-117, 137-159, 171-193, 197-219, 226-248 and 253-270 282458007456 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 282458007457 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 282458007458 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 202.30, E-value 7.5e-57 282458007459 PS00211 ABC transporters family signature. 282458007460 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007461 endonuclease IV; Provisional; Region: PRK01060 282458007462 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 282458007463 AP (apurinic/apyrimidinic) site pocket; other site 282458007464 DNA interaction; other site 282458007465 Metal-binding active site; metal-binding site 282458007466 Pfam match to entry PF01261 AP_endonulease2, AP endonuclease 2, score 496.50, E-value 2.1e-145 282458007467 PS00731 AP endonucleases family 2 signature 3. 282458007468 PS00729 AP endonucleases family 2 signature 1. 282458007469 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 282458007470 DEAD-like helicases superfamily; Region: DEXDc; smart00487 282458007471 ATP binding site [chemical binding]; other site 282458007472 Mg++ binding site [ion binding]; other site 282458007473 motif III; other site 282458007474 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282458007475 nucleotide binding region [chemical binding]; other site 282458007476 ATP-binding site [chemical binding]; other site 282458007477 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 106.50, E-value 5.1e-28 282458007478 Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase, score 158.60, E-value 3.1e-49 282458007479 Uncharacterized conserved protein [Function unknown]; Region: COG0327 282458007480 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 282458007481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 282458007482 Uncharacterized conserved protein [Function unknown]; Region: COG0327 282458007483 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 282458007484 Pfam match to entry PF01784 DUF34, Domain of unknown function DUF34, score 192.00, E-value 9.2e-54 282458007485 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 282458007486 Family of unknown function (DUF633); Region: DUF633; pfam04816 282458007487 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 282458007488 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 282458007489 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 282458007490 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 282458007491 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 282458007492 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 282458007493 DNA binding residues [nucleotide binding] 282458007494 Pfam match to entry PF00140 sigma70, Sigma-70 factor, score 469.50, E-value 2.8e-137 282458007495 PS00716 Sigma-70 factors family signature 2. 282458007496 Predicted helix-turn-helix motif with score 1909 (+5.69 SD) at aa 327-348, sequence RTLEEVGKVFGVTRERIRQIEA 282458007497 PS00715 Sigma-70 factors family signature 1. 282458007498 DNA primase, catalytic core; Region: dnaG; TIGR01391 282458007499 CHC2 zinc finger; Region: zf-CHC2; pfam01807 282458007500 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 282458007501 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 282458007502 active site 282458007503 metal binding site [ion binding]; metal-binding site 282458007504 interdomain interaction site; other site 282458007505 Pfam match to entry PF01751 Toprim, Toprim domain, score 73.40, E-value 4.8e-18 282458007506 Pfam match to entry PF01807 zf-CHC2, CHC2 zinc finger, score 198.40, E-value 1.1e-55 282458007507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 282458007508 Similar to Bacillus halodurans hypothetical protein BH1372 TR:Q9KD47 (EMBL:AP001511) (214 aa) fasta scores: E(): 2.3e-45, 56.522% id in 207 aa, and to Bacillus subtilis hypothetical protein YqzB TR:O34994 (EMBL:Z99116) (212 aa) fasta scores: E(): 6.5e-45, 58.333% id in 204 aa. CDS lacks an inframe translational start site. Frameshift or point mutation could generate a start codon. Possible alternative rare translational start at codon 4; DNA-binding protein (pseudogene) 282458007509 Pfam match to entry PF00571 CBS, CBS domain, score 20.40, E-value 0.041 282458007510 Pfam match to entry PF00571 CBS, CBS domain, score 22.00, E-value 0.014 282458007511 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007512 Predicted helix-turn-helix motif for SAR1641 with score 1511.000, SD 4.33 at aa 23-44, sequence ITGEQIADKLNLTRATLRPDLA 282458007513 glycyl-tRNA synthetase; Provisional; Region: PRK04173 282458007514 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 282458007515 motif 1; other site 282458007516 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 282458007517 active site 282458007518 motif 2; other site 282458007519 motif 3; other site 282458007520 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 282458007521 anticodon binding site; other site 282458007522 Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T), score 62.20, E-value 1.1e-14 282458007523 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007524 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 282458007525 DNA repair protein RecO; Region: reco; TIGR00613 282458007526 Recombination protein O N terminal; Region: RecO_N; pfam11967 282458007527 Recombination protein O C terminal; Region: RecO_C; pfam02565 282458007528 Pfam match to entry PF02565 RecO, Recombination protein O, score 5.80, E-value 1.6e-06 282458007529 GTPase Era; Reviewed; Region: era; PRK00089 282458007530 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 282458007531 G1 box; other site 282458007532 GTP/Mg2+ binding site [chemical binding]; other site 282458007533 Switch I region; other site 282458007534 G2 box; other site 282458007535 Switch II region; other site 282458007536 G3 box; other site 282458007537 G4 box; other site 282458007538 G5 box; other site 282458007539 KH domain; Region: KH_2; pfam07650 282458007540 Pfam match to entry PF00013 KH-domain, KH domain, score 14.90, E-value 0.068 282458007541 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007542 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 282458007543 active site 282458007544 catalytic motif [active] 282458007545 Zn binding site [ion binding]; other site 282458007546 Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region, score 62.60, E-value 8.3e-15 282458007547 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 282458007548 Pfam match to entry PF01219 DAGK_prokar, Prokaryotic diacylglycerol kinase, score 117.30, E-value 2.8e-31 282458007549 3 probable transmembrane helices predicted for SAR1646 by TMHMM2.0 at aa 21-38, 43-65 and 86-108 282458007550 PS01069 Prokaryotic diacylglycerol kinase signature. 282458007551 metal-binding heat shock protein; Provisional; Region: PRK00016 282458007552 Pfam match to entry PF02130 UPF0054, Uncharacterized protein family UPF0054, score 172.60, E-value 6.6e-48 282458007553 PS01306 Uncharacterized protein family UPF0054 signature. 282458007554 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 282458007555 PhoH-like protein; Region: PhoH; pfam02562 282458007556 Pfam match to entry PF02562 PhoH, PhoH-like protein, score 550.90, E-value 8.8e-162 282458007557 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007558 Signal peptide predicted for SAR1650 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.618 between residues 34 and 35; signal peptide 282458007559 hypothetical protein; Provisional; Region: PRK13665 282458007560 2 probable transmembrane helices predicted for SAR1650 by TMHMM2.0 at aa 2-24 and 28-47 282458007561 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 282458007562 4 probable transmembrane helices predicted for SAR1651 by TMHMM2.0 at aa 28-50, 57-79, 84-117 and 124-146 282458007563 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 282458007564 Pfam match to entry PF01165 Ribosomal_S21, Ribosomal protein S21, score 112.90, E-value 6e-30 282458007565 PS01181 Ribosomal protein S21 signature. 282458007566 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 282458007567 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 282458007568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282458007569 FeS/SAM binding site; other site 282458007570 TRAM domain; Region: TRAM; cl01282 282458007571 Pfam match to entry PF01938 TRAM, Domain of unknown function DUF90, score 23.90, E-value 0.0039 282458007572 PS01278 Uncharacterized protein family UPF0004 signature. 282458007573 Pfam match to entry PF00919 UPF0004, Uncharacterized protein family UPF0004, score 148.90, E-value 9.1e-41 282458007574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 282458007575 RNA methyltransferase, RsmE family; Region: TIGR00046 282458007576 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 282458007577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458007578 S-adenosylmethionine binding site [chemical binding]; other site 282458007579 chaperone protein DnaJ; Provisional; Region: PRK14280 282458007580 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 282458007581 HSP70 interaction site [polypeptide binding]; other site 282458007582 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 282458007583 substrate binding site [polypeptide binding]; other site 282458007584 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 282458007585 Zn binding sites [ion binding]; other site 282458007586 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 282458007587 dimer interface [polypeptide binding]; other site 282458007588 Pfam match to entry PF01556 DnaJ_C, DnaJ C terminal region, score 274.10, E-value 1.8e-78 282458007589 Pfam match to entry PF00684 DnaJ_CXXCXGXG, DnaJ central domain (4 repeats), score 155.20, E-value 1.1e-42 282458007590 PS00637 CXXCXGXG dnaJ domain signature. 282458007591 PS00190 Cytochrome c family heme-binding site signature. 282458007592 Pfam match to entry PF00226 DnaJ, DnaJ domain, score 144.60, E-value 1.8e-39 282458007593 PS00636 Nt-dnaJ domain signature. 282458007594 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 282458007595 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 282458007596 nucleotide binding site [chemical binding]; other site 282458007597 NEF interaction site [polypeptide binding]; other site 282458007598 SBD interface [polypeptide binding]; other site 282458007599 Pfam match to entry PF00012 HSP70, Hsp70 protein, score 1265.50, E-value 0 282458007600 PS01036 Heat shock hsp70 proteins family signature 3. 282458007601 PS00329 Heat shock hsp70 proteins family signature 2. 282458007602 PS00297 Heat shock hsp70 proteins family signature 1. 282458007603 heat shock protein GrpE; Provisional; Region: PRK14140 282458007604 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 282458007605 dimer interface [polypeptide binding]; other site 282458007606 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 282458007607 Pfam match to entry PF01025 GrpE, GrpE, score 289.30, E-value 5e-83 282458007608 PS01071 grpE protein signature. 282458007609 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 282458007610 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 282458007611 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 282458007612 Pfam match to entry PF01628 HrcA, HrcA protein, score 516.40, E-value 2.1e-151 282458007613 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 282458007614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282458007615 FeS/SAM binding site; other site 282458007616 HemN C-terminal domain; Region: HemN_C; pfam06969 282458007617 Pfam match to entry PF02473 Coprogen_an_ox, Oxygen-independent Coproporphyrinogen III oxidase, score -4.50, E-value 4.4e-14 282458007618 GTP-binding protein LepA; Provisional; Region: PRK05433 282458007619 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 282458007620 G1 box; other site 282458007621 putative GEF interaction site [polypeptide binding]; other site 282458007622 GTP/Mg2+ binding site [chemical binding]; other site 282458007623 Switch I region; other site 282458007624 G2 box; other site 282458007625 G3 box; other site 282458007626 Switch II region; other site 282458007627 G4 box; other site 282458007628 G5 box; other site 282458007629 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 282458007630 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 282458007631 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 282458007632 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family, score 368.00, E-value 9.6e-107 282458007633 PS00301 GTP-binding elongation factors signature. 282458007634 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007635 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 282458007636 Pfam match to entry PF01649 Ribosomal_S20p, Ribosomal protein S20, score 59.90, E-value 5.6e-14 282458007637 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 282458007638 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 282458007639 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 282458007640 Competence protein; Region: Competence; pfam03772 282458007641 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 282458007642 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 282458007643 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 33.80, E-value 2.9e-06 282458007644 11 probable transmembrane helices predicted for SAR1665 by TMHMM2.0 at aa 12-34, 38-57, 202-224, 229-248, 255-274, 278-297, 304-323, 328-350, 362-384, 423-440 and 445-462 282458007645 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 282458007646 catalytic motif [active] 282458007647 Zn binding site [ion binding]; other site 282458007648 Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region, score 149.80, E-value 4.9e-41 282458007649 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 282458007650 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 282458007651 Helix-hairpin-helix motif; Region: HHH; pfam00633 282458007652 Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif., score 37.80, E-value 2.4e-07 282458007653 1 probable transmembrane helix predicted for SAR1667 by TMHMM2.0 at aa 13-35 282458007654 Methyltransferase domain; Region: Methyltransf_23; pfam13489 282458007655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458007656 S-adenosylmethionine binding site [chemical binding]; other site 282458007657 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 282458007658 Pfam match to entry PF02410 DUF143, Domain of unknown function DUF143, score 135.60, E-value 8.7e-37 282458007659 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 282458007660 Zn2+ binding site [ion binding]; other site 282458007661 Mg2+ binding site [ion binding]; other site 282458007662 Pfam match to entry PF01966 HD, HD domain, score 58.70, E-value 1.3e-13 282458007663 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 282458007664 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 282458007665 active site 282458007666 (T/H)XGH motif; other site 282458007667 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 282458007668 Pfam match to entry PF01985 UPF0044, Uncharacterised protein family UPF0044, score 67.00, E-value 4.1e-16 282458007669 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 282458007670 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 282458007671 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 282458007672 shikimate binding site; other site 282458007673 NAD(P) binding site [chemical binding]; other site 282458007674 Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase, score 270.60, E-value 2.1e-77 282458007675 GTPase YqeH; Provisional; Region: PRK13796 282458007676 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 282458007677 GTP/Mg2+ binding site [chemical binding]; other site 282458007678 G4 box; other site 282458007679 G5 box; other site 282458007680 G1 box; other site 282458007681 Switch I region; other site 282458007682 G2 box; other site 282458007683 G3 box; other site 282458007684 Switch II region; other site 282458007685 Pfam match to entry PF01926 MMR_HSR1, GTPase of unknown function, score 96.00, E-value 7.5e-25 282458007686 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007687 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 282458007688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458007689 active site 282458007690 motif I; other site 282458007691 motif II; other site 282458007692 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 282458007693 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 282458007694 Pfam match to entry PF01048 PNP_UDP_1, Phosphorylase, score 297.70, E-value 1.4e-85 282458007695 3 probable transmembrane helices predicted for SAR1677 by TMHMM2.0 at aa 13-32, 42-64 and 71-88 282458007696 Similar to Staphylococcus aureus enterotoxin type A precursor EntA SW:ETXA_STAAU (P13163) (257 aa) fasta scores: E(): 1.4e-34, 41.339% id in 254 aa, and to Staphylococcus aureus enterotoxin type E precursor EntE SW:ETXE_STAAU (P12993) (257 aa) fasta scores: E(): 1.9e-32, 40.157% id in 254 aa. Contains a nonsense mutation (ochre) after codon 167; enterotoxin (pseudogene) 282458007697 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -16.90, E-value 0.1 282458007698 PS00277 Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin signature 1. 282458007699 Pfam match to entry PF01123 Stap_Strp_toxin, Staphylococcal/Streptococcal toxin, OB-fold domain, score 82.90, E-value 6.6e-21 282458007700 Signal peptide predicted for SAR1679 by SignalP 2.0 HMM (Signal peptide probabilty 0.627) with cleavage site probability 0.624 between residues 28 and 29 282458007701 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 282458007702 Poor database matches. Similar to bacteriophage TP901-1 hypothetical protein Orf56 TR:Q9AZ49 (EMBL:AF304433) (418 aa) fasta scores: E(): 6e-36, 34.223% id in 412 aa. Contains a frameshift after codon 63. Frameshift occurs at a poly A heptamer;hypothetical phage protein (pseudogene) 282458007703 Predicted helix-turn-helix motif with score 983 (+2.53 SD) at aa 224-245, sequence LTLIDLENILGVGRVKINNTIK 282458007704 Signal peptide predicted for SAR1683 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.925 between residues 58 and 59; signal peptide 282458007705 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 282458007706 11 probable transmembrane helices predicted for SAR1683 by TMHMM2.0 at aa 24-46, 56-78, 91-110, 125-147, 154-176, 196-218, 239-261, 289-311, 324-341, 346-368 and 381-403 282458007707 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 282458007708 putative active site [active] 282458007709 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 282458007710 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 282458007711 ATP-grasp domain; Region: ATP-grasp_4; cl17255 282458007712 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 282458007713 Pfam match to entry PF02785 Biotin_carb_C, Biotin carboxylase C-terminal domain, score 161.80, E-value 1.2e-44 282458007714 Pfam match to entry PF02786 CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain, score 271.30, E-value 1.2e-77 282458007715 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 282458007716 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 282458007717 Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase L chain, N-terminal domain, score 149.00, E-value 8.2e-41 282458007718 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 282458007719 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 282458007720 carboxyltransferase (CT) interaction site; other site 282458007721 biotinylation site [posttranslational modification]; other site 282458007722 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme, score 74.30, E-value 2.5e-18 282458007723 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 282458007724 Pfam match to entry PF02626 DUF183, Uncharacterized ACR, COG1984, score 235.30, E-value 8.7e-67 282458007725 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 282458007726 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 282458007727 Pfam match to entry PF02682 DUF213, Uncharacterized ACR, COG2049, score 224.60, E-value 1.4e-63 282458007728 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 282458007729 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 282458007730 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 282458007731 Pfam match to entry PF01272 GreA_GreB, Prokaryotic transcription elongation factor, GreA/GreB, score 201.70, E-value 1.1e-56 282458007732 PS00830 Prokaryotic transcription elongation factors signature 2. 282458007733 PS00829 Prokaryotic transcription elongation factors signature 1. 282458007734 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 282458007735 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 282458007736 Sugar specificity; other site 282458007737 Pyrimidine base specificity; other site 282458007738 ATP-binding site [chemical binding]; other site 282458007739 Pfam match to entry PF00485 PRK, Phosphoribulokinase / Uridine kinase, score 179.60, E-value 5.1e-50 282458007740 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007741 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 282458007742 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 282458007743 Peptidase family U32; Region: Peptidase_U32; pfam01136 282458007744 Pfam match to entry PF01136 Peptidase_U32, Peptidase U32, score 226.20, E-value 4.9e-64 282458007745 PS01276 Peptidase U32 signature. 282458007746 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 282458007747 Peptidase family U32; Region: Peptidase_U32; pfam01136 282458007748 Pfam match to entry PF01136 Peptidase_U32, Peptidase U32, score 88.90, E-value 1e-22 282458007749 PS00018 EF-hand calcium-binding domain. 282458007750 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 282458007751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458007752 S-adenosylmethionine binding site [chemical binding]; other site 282458007753 Pfam match to entry PF01596 Methyltransf_3, O-methyltransferase, score -32.10, E-value 4.4e-07 282458007754 hypothetical protein; Provisional; Region: PRK13678 282458007755 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 282458007756 hypothetical protein; Provisional; Region: PRK05473 282458007757 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 282458007758 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 282458007759 motif 1; other site 282458007760 active site 282458007761 motif 2; other site 282458007762 motif 3; other site 282458007763 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 282458007764 DHHA1 domain; Region: DHHA1; pfam02272 282458007765 Pfam match to entry PF02272 DHHA1, DHHA1 domain, score 63.50, E-value 4.5e-15 282458007766 Pfam match to entry PF01411 tRNA-synt_2c, tRNA synthetases class II (A), score 1346.70, E-value 0 282458007767 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282458007768 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 282458007769 AAA domain; Region: AAA_30; pfam13604 282458007770 Family description; Region: UvrD_C_2; pfam13538 282458007771 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 282458007773 binding surface 282458007774 TPR motif; other site 282458007775 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 282458007776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 282458007777 binding surface 282458007778 TPR motif; other site 282458007779 TPR repeat; Region: TPR_11; pfam13414 282458007780 Pfam match to entry PF00515 TPR, TPR Domain, score 21.60, E-value 0.018 282458007781 Pfam match to entry PF00515 TPR, TPR Domain, score 13.40, E-value 1.7 282458007782 Pfam match to entry PF00515 TPR, TPR Domain, score 13.50, E-value 1.6 282458007783 Pfam match to entry PF00515 TPR, TPR Domain, score 28.70, E-value 0.00014 282458007784 Pfam match to entry PF00515 TPR, TPR Domain, score 25.90, E-value 0.00092 282458007785 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 282458007786 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 282458007787 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 282458007788 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 282458007789 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282458007790 catalytic residue [active] 282458007791 Pfam match to entry PF00266 aminotran_5, Aminotransferase class-V, score 340.70, E-value 1.7e-98 282458007792 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 282458007793 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 282458007794 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 282458007795 Pfam match to entry PF00296 bac_luciferase, Bacterial luciferase, score 185.70, E-value 7.3e-52 282458007796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 282458007797 Predicted transcriptional regulator [Transcription]; Region: COG1959 282458007798 Transcriptional regulator; Region: Rrf2; pfam02082 282458007799 Pfam match to entry PF02082 UPF0074, Uncharacterized protein family UPF0074, score 138.70, E-value 1.1e-37 282458007800 PS01332 Uncharacterized protein family UPF0074 signature. 282458007801 recombination factor protein RarA; Reviewed; Region: PRK13342 282458007802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458007803 Walker A motif; other site 282458007804 ATP binding site [chemical binding]; other site 282458007805 Walker B motif; other site 282458007806 arginine finger; other site 282458007807 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 282458007808 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA), score 44.90, E-value 1.7e-09 282458007809 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007810 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 282458007811 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 282458007812 putative ATP binding site [chemical binding]; other site 282458007813 putative substrate interface [chemical binding]; other site 282458007814 Pfam match to entry PF00899 ThiF_family, ThiF family, score 117.60, E-value 2.4e-31 282458007815 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 282458007816 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 282458007817 dimer interface [polypeptide binding]; other site 282458007818 anticodon binding site; other site 282458007819 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 282458007820 homodimer interface [polypeptide binding]; other site 282458007821 motif 1; other site 282458007822 active site 282458007823 motif 2; other site 282458007824 GAD domain; Region: GAD; pfam02938 282458007825 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 282458007826 motif 3; other site 282458007827 Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N), score 73.80, E-value 4.3e-19 282458007828 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282458007829 Pfam match to entry PF02938 GAD, tRNA synthetases class II (D, K and N), score 137.40, E-value 2.6e-37 282458007830 Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N), score 99.10, E-value 5.8e-26 282458007831 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 282458007832 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain, score 65.70, E-value 9.7e-16 282458007833 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 282458007834 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 282458007835 dimer interface [polypeptide binding]; other site 282458007836 motif 1; other site 282458007837 active site 282458007838 motif 2; other site 282458007839 motif 3; other site 282458007840 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 282458007841 anticodon binding site; other site 282458007842 Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T), score 206.50, E-value 4e-58 282458007843 Identical to Staphylococcus aureus N-acetylmuramoyl-L-alanine amidase LytH or SAV1632 or SA1458 or MW1582 SWALL:O32421 (EMBL:D76414) (291 aa) fasta scores: E(): 7.4e-110, 100% id in 291 aa. Similar to Staphylococcus epidermidis N-acetylmuramoyl-L-alanine amidase SE1313 SWALL:Q8CP02 (EMBL:AE016748) (291 aa) fasta scores: E(): 2.7e-83, 71.82% id in 291 aa. CDS contains a frameshift after codon 9. Frame shift occurs at a poly A tetramer; N-acetylmuramoyl-L-alanine amidase (pseudogene) 282458007844 Pfam match to entry PF01520 Amidase_3, N-acetylmuramoyl-L-alanine amidase, score 168.90, E-value 8.3e-47 282458007845 Signal peptide predicted for SAR1712 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.541 between residues 40 and 41 282458007846 1 probable transmembrane helix predicted for SAR1712 by TMHMM2.0 at aa 19-36 282458007847 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 282458007848 putative active site [active] 282458007849 dimerization interface [polypeptide binding]; other site 282458007850 putative tRNAtyr binding site [nucleotide binding]; other site 282458007851 Pfam match to entry PF02580 DUF154, Uncharacterized ACR, COG1490, score 197.70, E-value 1.8e-55 282458007852 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 282458007853 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 282458007854 Zn2+ binding site [ion binding]; other site 282458007855 Mg2+ binding site [ion binding]; other site 282458007856 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 282458007857 synthetase active site [active] 282458007858 NTP binding site [chemical binding]; other site 282458007859 metal binding site [ion binding]; metal-binding site 282458007860 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 282458007861 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 282458007862 Pfam match to entry PF01842 ACT, ACT domain, score 40.10, E-value 5.1e-08 282458007863 Pfam match to entry PF02824 TGS, TGS domain, score 103.00, E-value 5.7e-27 282458007864 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282458007865 active site 282458007866 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 171.50, E-value 1.4e-47 282458007867 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 282458007868 DHH family; Region: DHH; pfam01368 282458007869 DHHA1 domain; Region: DHHA1; pfam02272 282458007870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 282458007871 Pfam match to entry PF02272 DHHA1, DHHA1 domain, score 30.00, E-value 5.4e-05 282458007872 Pfam match to entry PF01368 DHH, DHH family, score 170.50, E-value 2.7e-47 282458007873 Signal peptide predicted for SAR1717 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.416 between residues 22 and 23; signal peptide 282458007874 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 282458007875 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 282458007876 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 282458007877 Protein export membrane protein; Region: SecD_SecF; pfam02355 282458007878 Pfam match to entry PF02355 SecD_SecF, Protein export membrane protein, score 332.40, E-value 5.2e-96 282458007879 12 probable transmembrane helices predicted for SAR1717 by TMHMM2.0 at aa 7-29, 262-281, 288-310, 314-336, 356-378, 388-410, 456-478, 574-591, 598-620, 625-647, 681-703 and 707-729 282458007880 Preprotein translocase subunit; Region: YajC; pfam02699 282458007881 Pfam match to entry PF02699 DUF219, Uncharacterized secreted proteins, YajC family COG1862, score 97.20, E-value 3.3e-25 282458007882 1 probable transmembrane helix predicted for SAR1718 by TMHMM2.0 at aa 4-21 282458007883 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 282458007884 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 282458007885 Pfam match to entry PF01702 TGT, Queuine tRNA-ribosyltransferase, score 546.10, E-value 2.4e-160 282458007886 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 282458007887 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 282458007888 Pfam match to entry PF02547 Queuosine_synth, Queuosine biosynthesis protein, score 387.80, E-value 1.1e-112 282458007889 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 282458007890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458007891 Walker A motif; other site 282458007892 ATP binding site [chemical binding]; other site 282458007893 Walker B motif; other site 282458007894 arginine finger; other site 282458007895 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 282458007896 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA), score 110.10, E-value 4.4e-29 282458007897 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007898 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 282458007899 RuvA N terminal domain; Region: RuvA_N; pfam01330 282458007900 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 282458007901 Pfam match to entry PF02904 RuvA_II, RuvA central domain II, score 121.60, E-value 1.4e-32 282458007902 Pfam match to entry PF01330 RuvA, RuvA N terminal domain, score 82.60, E-value 8.1e-21 282458007903 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 282458007904 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 282458007905 Pfam match to entry PF01842 ACT, ACT domain, score 29.10, E-value 9.9e-05 282458007906 Predicted helix-turn-helix motif with score 1182 (+3.21 SD) at aa 38-59, sequence LSIYDAVKQFDLSRSAFYKYRE 282458007907 GTPase CgtA; Reviewed; Region: obgE; PRK12297 282458007908 GTP1/OBG; Region: GTP1_OBG; pfam01018 282458007909 Obg GTPase; Region: Obg; cd01898 282458007910 G1 box; other site 282458007911 GTP/Mg2+ binding site [chemical binding]; other site 282458007912 Switch I region; other site 282458007913 G2 box; other site 282458007914 G3 box; other site 282458007915 Switch II region; other site 282458007916 G4 box; other site 282458007917 G5 box; other site 282458007918 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 282458007919 Pfam match to entry PF01018 GTP1_OBG, GTP1/OBG family, score 407.90, E-value 9.4e-119 282458007920 PS00905 GTP1/OBG family signature. 282458007921 PS00017 ATP/GTP-binding site motif A (P-loop). 282458007922 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 282458007923 Pfam match to entry PF01016 Ribosomal_L27, Ribosomal L27 protein, score 185.70, E-value 7.3e-52 282458007924 PS00831 Ribosomal protein L27 signature. 282458007925 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 282458007926 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 282458007927 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 282458007928 Pfam match to entry PF00829 Ribosomal_L21p, Ribosomal prokaryotic L21 protein, score 174.10, E-value 2.3e-48 282458007929 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 282458007930 5 probable transmembrane helices predicted for SAR1728 by TMHMM2.0 at aa 5-27, 42-64, 71-93, 103-125 and 137-159 282458007931 Signal peptide predicted for SAR1729 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.904 between residues 32 and 33; signal peptide 282458007932 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 282458007933 rod shape-determining protein MreC; Region: MreC; pfam04085 282458007934 1 probable transmembrane helix predicted for SAR1729 by TMHMM2.0 at aa 10-28 282458007935 1 probable transmembrane helix predicted for SAR1730 by TMHMM2.0 at aa 3-25 282458007936 Signal peptide predicted for SAR1731 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.758 between residues 24 and 25; signal peptide 282458007937 2 probable transmembrane helices predicted for SAR1731 by TMHMM2.0 at aa 5-27 and 32-54 282458007938 3 probable transmembrane helices predicted for SAR1732 by TMHMM2.0 at aa 4-21, 30-52 and 62-84 282458007939 Similar to Escherichia coli DNA repair protein RadC SWALL:RADC_ECOLI (SWALL:P25531) (222 aa) fasta scores: E(): 1.2e-19, 34.11% id in 214 aa, and to Bacillus subtilis DNA repair protein RadC homolog BSU28040 SWALL:RADC_BACSU (SWALL:Q02170) (231 aa) fasta scores: E(): 7.6e-39, 53.12% id in 224 aa. CDS is disrupted by the insertion of Tn554 after residue 180;DNA repair protein RadC (pseudogene) 282458007940 Transposon Tn554 282458007941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458007942 S-adenosylmethionine binding site [chemical binding]; other site 282458007943 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 282458007944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458007945 S-adenosylmethionine binding site [chemical binding]; other site 282458007946 Pfam match to entry PF00398 RrnaAD, Ribosomal RNA adenine dimethylases, score 425.90, E-value 9.3e-132 282458007947 PS01131 Ribosomal RNA adenine dimethylases signature. 282458007948 aminoglycoside resistance protein; Provisional; Region: PRK13746 282458007949 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 282458007950 active site 282458007951 NTP binding site [chemical binding]; other site 282458007952 metal binding triad [ion binding]; metal-binding site 282458007953 antibiotic binding site [chemical binding]; other site 282458007954 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 282458007955 Pfam match to entry PF01909 NTP_transf_2, Nucleotidyltransferase domain, score 82.10, E-value 1.2e-20 282458007956 Predicted helix-turn-helix motif with score 1150 (+3.10 SD) at aa 40-61, sequence INFNSIAKEANVSKSWLYKEHD 282458007957 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 282458007958 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 282458007959 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 282458007960 Int/Topo IB signature motif; other site 282458007961 PS00018 EF-hand calcium-binding domain. 282458007962 Pfam match to entry PF00589 Phage_integrase, Phage integrase, score 152.60, E-value 7e-42 282458007963 Pfam match to entry PF02899 Phage_integr_N, Phage integrase, N-terminal SAM-like domain, score 3.10, E-value 0.29 282458007964 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 282458007965 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 282458007966 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 282458007967 Int/Topo IB signature motif; other site 282458007968 Pfam match to entry PF00589 Phage_integrase, Phage integrase, score 196.40, E-value 4.4e-55 282458007969 Pfam match to entry PF02899 Phage_integr_N, Phage integrase, N-terminal SAM-like domain, score 25.40, E-value 0.0014 282458007970 PS01302 DNA repair protein radC family signature. 282458007971 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 282458007972 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 282458007973 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 282458007974 6 probable transmembrane helices predicted for SAR1741 by TMHMM2.0 at aa 68-86, 90-109, 122-144, 154-176, 178-200 and 205-223 282458007975 Pfam match to entry PF01478 Peptidase_C20, Type III leader peptidase, score 41.00, E-value 3.5e-10 282458007976 PS00190 Cytochrome c family heme-binding site signature. 282458007977 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 282458007978 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 282458007979 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 282458007980 Pfam match to entry PF02875 Mur_ligase_C, Mur ligase, glutamate ligase domain, score 17.00, E-value 0.0061 282458007981 Pfam match to entry PF01225 Mur_ligase, Mur ligase, catalytic domain, score 76.60, E-value 1e-21 282458007982 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 282458007983 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 282458007984 active site 282458007985 HIGH motif; other site 282458007986 nucleotide binding site [chemical binding]; other site 282458007987 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 282458007988 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 282458007989 active site 282458007990 KMSKS motif; other site 282458007991 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 282458007992 tRNA binding surface [nucleotide binding]; other site 282458007993 anticodon binding site; other site 282458007994 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 282458007995 Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V), score 1030.90, E-value 0 282458007996 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282458007997 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 282458007998 Signal peptide predicted for SAR1745 by SignalP 2.0 HMM (Signal peptide probabilty 0.805) with cleavage site probability 0.392 between residues 39 and 40; signal peptide 282458007999 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 282458008000 Putative ammonia monooxygenase; Region: AmoA; pfam05145 282458008001 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 282458008002 8 probable transmembrane helices predicted for SAR1745 by TMHMM2.0 at aa 7-29, 83-105, 140-162, 182-204, 213-235, 269-291, 298-320 and 330-348 282458008003 similar to hypothetical protein; Doubtful CDS. No significant database matches 282458008004 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 282458008005 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 282458008006 inhibitor-cofactor binding pocket; inhibition site 282458008007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458008008 catalytic residue [active] 282458008009 Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III, score 426.30, E-value 1.4e-127 282458008010 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 282458008011 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 282458008012 dimer interface [polypeptide binding]; other site 282458008013 active site 282458008014 Schiff base residues; other site 282458008015 Pfam match to entry PF00490 ALAD, Delta-aminolevulinic acid dehydratase, score 654.90, E-value 1.2e-193 282458008016 PS00169 Delta-aminolevulinic acid dehydratase active site. 282458008017 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 282458008018 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 282458008019 active site 282458008020 Pfam match to entry PF02602 HEM4, Uroporphyrinogen-III synthase HemD, score 105.40, E-value 1.1e-27 282458008021 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 282458008022 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 282458008023 domain interfaces; other site 282458008024 active site 282458008025 Pfam match to entry PF01379 Porphobil_deam, Porphobilinogen deaminase, score 607.60, E-value 7.2e-179 282458008026 PS00533 Porphobilinogen deaminase cofactor-binding site. 282458008027 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 282458008028 8 probable transmembrane helices predicted for SAR1751 by TMHMM2.0 at aa 4-26, 38-60, 65-87, 92-114, 134-156, 184-206, 221-240 and 247-269 282458008029 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 282458008030 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 282458008031 tRNA; other site 282458008032 putative tRNA binding site [nucleotide binding]; other site 282458008033 putative NADP binding site [chemical binding]; other site 282458008034 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 282458008035 Pfam match to entry PF00745 GlutR, Glutamyl-tRNAGlu reductase, score 557.40, E-value 9.5e-164 282458008036 PS00747 Glutamyl-tRNA reductase signature. 282458008037 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 282458008038 G1 box; other site 282458008039 GTP/Mg2+ binding site [chemical binding]; other site 282458008040 Switch I region; other site 282458008041 G2 box; other site 282458008042 G3 box; other site 282458008043 Switch II region; other site 282458008044 G4 box; other site 282458008045 G5 box; other site 282458008046 PS00017 ATP/GTP-binding site motif A (P-loop). 282458008047 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 282458008048 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 282458008049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458008050 Walker A motif; other site 282458008051 ATP binding site [chemical binding]; other site 282458008052 Walker B motif; other site 282458008053 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 282458008054 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA), score 86.50, E-value 5.5e-22 282458008055 PS00017 ATP/GTP-binding site motif A (P-loop). 282458008056 trigger factor; Provisional; Region: tig; PRK01490 282458008057 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 282458008058 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 282458008059 Pfam match to entry PF00254 FKBP, FKBP-type peptidyl-prolyl cis-trans isomerases, score 26.90, E-value 4.5e-07 282458008060 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 282458008061 Pfam match to entry PF00293 NUDIX, MutT-like domain, score 11.90, E-value 0.023 282458008062 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 282458008063 23S rRNA binding site [nucleotide binding]; other site 282458008064 L21 binding site [polypeptide binding]; other site 282458008065 L13 binding site [polypeptide binding]; other site 282458008066 Pfam match to entry PF00453 Ribosomal_L20, Ribosomal protein L20, score 236.80, E-value 2.1e-74 282458008067 PS00937 Ribosomal protein L20 signature. 282458008068 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 282458008069 Pfam match to entry PF01632 Ribosomal_L35p, Ribosomal protein L35, score 107.40, E-value 2.8e-28 282458008070 PS00936 Ribosomal protein L35 signature. 282458008071 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 282458008072 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 282458008073 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 282458008074 Pfam match to entry PF00707 IF3, Translation initiation factor IF-3, score 334.00, E-value 5.6e-111 282458008075 PS00938 Initiation factor 3 signature. 282458008076 Signal peptide predicted for SAR1761 by SignalP 2.0 HMM (Signal peptide probabilty 0.899) with cleavage site probability 0.744 between residues 41 and 42; signal peptide 282458008077 lysine transporter; Provisional; Region: PRK10836 282458008078 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score 680.80, E-value 6.9e-201 282458008079 12 probable transmembrane helices predicted for SAR1761 by TMHMM2.0 at aa 21-43, 47-69, 101-123, 128-150, 162-184, 199-221, 250-269, 295-317, 347-369, 373-395, 416-438 and 453-470 282458008080 PS00017 ATP/GTP-binding site motif A (P-loop). 282458008081 PS00218 Amino acid permeases signature. 282458008082 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 282458008083 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 282458008084 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 282458008085 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 282458008086 active site 282458008087 dimer interface [polypeptide binding]; other site 282458008088 motif 1; other site 282458008089 motif 2; other site 282458008090 motif 3; other site 282458008091 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 282458008092 anticodon binding site; other site 282458008093 Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T), score 418.00, E-value 8.7e-122 282458008094 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282458008095 Pfam match to entry PF02824 TGS, TGS domain, score 65.80, E-value 9.1e-16 282458008096 primosomal protein DnaI; Reviewed; Region: PRK08939 282458008097 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 282458008098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458008099 Walker A motif; other site 282458008100 ATP binding site [chemical binding]; other site 282458008101 Walker B motif; other site 282458008102 PS00017 ATP/GTP-binding site motif A (P-loop). 282458008103 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 282458008104 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 282458008105 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 282458008106 ATP cone domain; Region: ATP-cone; pfam03477 282458008107 Pfam match to entry PF02644 DUF193, Uncharacterized BCR, COG1327, score 240.70, E-value 2e-68 282458008108 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 282458008109 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 282458008110 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 282458008111 Pfam match to entry PF02800 gpdh_C, Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, score 335.20, E-value 7.3e-97 282458008112 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 282458008113 Pfam match to entry PF00044 gpdh, Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain, score 224.00, E-value 2.9e-92 282458008114 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 282458008115 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 282458008116 CoA-binding site [chemical binding]; other site 282458008117 ATP-binding [chemical binding]; other site 282458008118 Pfam match to entry PF01121 CoaE, Uncharacterized protein family UPF0038, score 243.20, E-value 3.7e-69 282458008119 PS00017 ATP/GTP-binding site motif A (P-loop). 282458008120 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 282458008121 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 282458008122 DNA binding site [nucleotide binding] 282458008123 catalytic residue [active] 282458008124 H2TH interface [polypeptide binding]; other site 282458008125 putative catalytic residues [active] 282458008126 turnover-facilitating residue; other site 282458008127 intercalation triad [nucleotide binding]; other site 282458008128 8OG recognition residue [nucleotide binding]; other site 282458008129 putative reading head residues; other site 282458008130 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 282458008131 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 282458008132 Pfam match to entry PF01149 Fapy_DNA_glyco, Formamidopyrimidine-DNA glycosylase, score 248.20, E-value 1.1e-70 282458008133 DNA polymerase I; Provisional; Region: PRK05755 282458008134 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 282458008135 active site 282458008136 metal binding site 1 [ion binding]; metal-binding site 282458008137 putative 5' ssDNA interaction site; other site 282458008138 metal binding site 3; metal-binding site 282458008139 metal binding site 2 [ion binding]; metal-binding site 282458008140 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 282458008141 putative DNA binding site [nucleotide binding]; other site 282458008142 putative metal binding site [ion binding]; other site 282458008143 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 282458008144 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 282458008145 active site 282458008146 DNA binding site [nucleotide binding] 282458008147 catalytic site [active] 282458008148 Pfam match to entry PF00476 DNA_pol_A, DNA polymerase A, score 642.40, E-value 2.4e-189 282458008149 PS00447 DNA polymerase A signature. 282458008150 Pfam match to entry PF01367 5_3_exonuclease, 5'-3' exonuclease, C-terminal SAM fold, score 170.60, E-value 1.9e-50 282458008151 Pfam match to entry PF02739 5_3_exonuc_N, 5'-3' exonuclease, N-terminal resolvase-like domain, score 307.80, E-value 1.3e-88 282458008152 13 probable transmembrane helices predicted for SAR1770 by TMHMM2.0 at aa 9-31, 63-85, 98-116, 126-148, 153-170, 174-191, 198-215, 254-276, 289-311, 321-343, 350-372, 377-392 and 404-426 282458008153 Signal peptide predicted for SAR1771 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.987 between residues 29 and 30; signal peptide 282458008154 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 282458008155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282458008156 dimer interface [polypeptide binding]; other site 282458008157 phosphorylation site [posttranslational modification] 282458008158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458008159 ATP binding site [chemical binding]; other site 282458008160 Mg2+ binding site [ion binding]; other site 282458008161 G-X-G motif; other site 282458008162 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 156.80, E-value 3.8e-43 282458008163 Pfam match to entry PF00512 signal, His Kinase A (phosphoacceptor) domain, score 84.80, E-value 1.8e-21 282458008164 Pfam match to entry PF00989 PAS, PAS domain, score 24.30, E-value 4.2e-05 282458008165 Pfam match to entry PF00672 HAMP, HAMP domain, score 19.80, E-value 0.065 282458008166 2 probable transmembrane helices predicted for SAR1771 by TMHMM2.0 at aa 10-32 and 128-150 282458008167 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282458008168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458008169 active site 282458008170 phosphorylation site [posttranslational modification] 282458008171 intermolecular recognition site; other site 282458008172 dimerization interface [polypeptide binding]; other site 282458008173 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282458008174 DNA binding site [nucleotide binding] 282458008175 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 127.00, E-value 1e-36 282458008176 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 156.00, E-value 6.6e-43 282458008177 isocitrate dehydrogenase; Reviewed; Region: PRK07006 282458008178 isocitrate dehydrogenase; Validated; Region: PRK07362 282458008179 Pfam match to entry PF00180 isodh, Isocitrate and isopropylmalate dehydrogenases, score 561.90, E-value 2.5e-167 282458008180 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 282458008181 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 282458008182 dimer interface [polypeptide binding]; other site 282458008183 Citrate synthase; Region: Citrate_synt; pfam00285 282458008184 active site 282458008185 citrylCoA binding site [chemical binding]; other site 282458008186 oxalacetate/citrate binding site [chemical binding]; other site 282458008187 coenzyme A binding site [chemical binding]; other site 282458008188 catalytic triad [active] 282458008189 Pfam match to entry PF00285 citrate_synt, Citrate synthase, score 524.80, E-value 1.3e-164 282458008190 PS00480 Citrate synthase signature. 282458008191 Signal peptide predicted for SAR1775 by SignalP 2.0 HMM (Signal peptide probabilty 0.674) with cleavage site probability 0.406 between residues 36 and 37; signal peptide 282458008192 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 282458008193 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score 531.00, E-value 8.1e-156 282458008194 12 probable transmembrane helices predicted for SAR1775 by TMHMM2.0 at aa 13-35, 39-61, 80-102, 122-144, 151-173, 198-220, 233-255, 270-292, 327-349, 359-381, 401-423 and 427-444 282458008195 pyruvate kinase; Provisional; Region: PRK06354 282458008196 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 282458008197 domain interfaces; other site 282458008198 active site 282458008199 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 282458008200 Pfam match to entry PF00391 PEP-utilizers, PEP-utilizing enzyme, mobile domain, score 42.60, E-value 8.8e-09 282458008201 Pfam match to entry PF02887 PK_C, Pyruvate kinase, alpha/beta domain, score 157.10, E-value 3e-43 282458008202 Pfam match to entry PF00224 PK, Pyruvate kinase, barrel domain, score 736.40, E-value 1.3e-217 282458008203 6-phosphofructokinase; Provisional; Region: PRK03202 282458008204 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 282458008205 active site 282458008206 ADP/pyrophosphate binding site [chemical binding]; other site 282458008207 dimerization interface [polypeptide binding]; other site 282458008208 allosteric effector site; other site 282458008209 fructose-1,6-bisphosphate binding site; other site 282458008210 Pfam match to entry PF00365 PFK, Phosphofructokinase, score 554.90, E-value 7.3e-203 282458008211 PS00433 Phosphofructokinase signature. 282458008212 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 282458008213 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 282458008214 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 282458008215 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 282458008216 Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain, score 41.10, E-value 2.9e-10 282458008217 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 282458008218 Malic enzyme, N-terminal domain; Region: malic; pfam00390 282458008219 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 282458008220 putative NAD(P) binding site [chemical binding]; other site 282458008221 Pfam match to entry PF00390 malic, Malic enzyme, score 29.90, E-value 1.7e-06 282458008222 Pfam match to entry PF00390 malic, Malic enzyme, score 39.10, E-value 8e-09 282458008223 PS00331 Malic enzymes signature. 282458008224 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 282458008225 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 282458008226 active site 282458008227 PHP Thumb interface [polypeptide binding]; other site 282458008228 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 282458008229 generic binding surface I; other site 282458008230 generic binding surface II; other site 282458008231 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain, score 21.10, E-value 0.025 282458008232 PS00017 ATP/GTP-binding site motif A (P-loop). 282458008233 Pfam match to entry PF02231 PHP_N, PHP domain N-terminal region, score 61.30, E-value 2.1e-14 282458008234 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 282458008235 DHH family; Region: DHH; pfam01368 282458008236 DHHA1 domain; Region: DHHA1; pfam02272 282458008237 Pfam match to entry PF02272 DHHA1, DHHA1 domain, score 28.80, E-value 0.00013 282458008238 PS00126 3'5'-cyclic nucleotide phosphodiesterases signature. 282458008239 Pfam match to entry PF01368 DHH, DHH family, score 125.60, E-value 9.4e-34 282458008240 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 282458008241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 282458008242 DNA-binding site [nucleotide binding]; DNA binding site 282458008243 DRTGG domain; Region: DRTGG; pfam07085 282458008244 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 282458008245 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 282458008246 active site 2 [active] 282458008247 active site 1 [active] 282458008248 Pfam match to entry PF00571 CBS, CBS domain, score 36.70, E-value 5.1e-07 282458008249 Pfam match to entry PF00571 CBS, CBS domain, score 43.00, E-value 6.6e-09 282458008250 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282458008251 Predicted helix-turn-helix motif with score 1841 (+5.46 SD) at aa 20-41, sequence ISVRKIAKFLNVSEGTAYRAIK 282458008252 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 282458008253 Ligand Binding Site [chemical binding]; other site 282458008254 Pfam match to entry PF00582 Usp, Universal stress protein family, score 46.40, E-value 6.4e-10 282458008255 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 282458008256 metal-dependent hydrolase; Provisional; Region: PRK00685 282458008257 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 8.30, E-value 0.0006 282458008258 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 282458008259 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 282458008260 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 282458008261 active site 282458008262 Pfam match to entry PF00557 Peptidase_M24, metallopeptidase M24, score 227.60, E-value 1.8e-64 282458008263 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 282458008264 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 282458008265 hexamer interface [polypeptide binding]; other site 282458008266 ligand binding site [chemical binding]; other site 282458008267 putative active site [active] 282458008268 NAD(P) binding site [chemical binding]; other site 282458008269 Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase, score 715.40, E-value 2.7e-211 282458008270 PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. 282458008271 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 282458008272 Ligand Binding Site [chemical binding]; other site 282458008273 Pfam match to entry PF00582 Usp, Universal stress protein family, score 79.80, E-value 5.4e-20 282458008274 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 282458008275 propionate/acetate kinase; Provisional; Region: PRK12379 282458008276 Pfam match to entry PF00871 Acetate_kinase, Acetokinase, score 762.80, E-value 1.4e-225 282458008277 PS00017 ATP/GTP-binding site motif A (P-loop). 282458008278 PS01076 Acetate and butyrate kinases family signature 2. 282458008279 PS00430 TonB-dependent receptor proteins signature 1. 282458008280 PS01075 Acetate and butyrate kinases family signature 1. 282458008281 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 282458008282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458008283 S-adenosylmethionine binding site [chemical binding]; other site 282458008284 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 282458008285 dimer interface [polypeptide binding]; other site 282458008286 catalytic triad [active] 282458008287 peroxidatic and resolving cysteines [active] 282458008288 Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family, score 100.40, E-value 3.5e-26 282458008289 PS01265 Tpx family signature. 282458008290 Signal peptide predicted for SAR1792 by SignalP 2.0 HMM (Signal peptide probabilty 0.863) with cleavage site probability 0.177 between residues 27 and 28; signal peptide 282458008291 hypothetical protein; Provisional; Region: PRK10621 282458008292 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 282458008293 Pfam match to entry PF01925 DUF81, Domain of unknown function DUF81, score 44.30, E-value 1.8e-11 282458008294 7 probable transmembrane helices predicted for SAR1792 by TMHMM2.0 at aa 5-27, 73-95, 100-119, 132-154, 159-178, 191-213 and 223-245 282458008295 Pfam match to entry PF01925 DUF81, Domain of unknown function DUF81, score 20.80, E-value 9e-05 282458008296 PS00061 Short-chain dehydrogenases/reductases family signature. 282458008297 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 282458008298 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 282458008299 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 282458008300 Ligand Binding Site [chemical binding]; other site 282458008301 Pfam match to entry PF02568 ThiI, Thiamine biosynthesis protein (ThiI), score 305.50, E-value 6.3e-88 282458008302 Pfam match to entry PF02926 THUMP, , score 60.20, E-value 4.4e-14 282458008303 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 282458008304 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 282458008305 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282458008306 catalytic residue [active] 282458008307 Pfam match to entry PF00266 aminotran_5, Aminotransferase class-V, score 247.50, E-value 1.8e-70 282458008308 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 282458008309 1 probable transmembrane helix predicted for SAR1795 by TMHMM2.0 at aa 2-24 282458008310 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 282458008311 GAF domain; Region: GAF_2; pfam13185 282458008312 Pfam match to entry PF01590 GAF, GAF domain, score 25.00, E-value 0.0018 282458008313 PS01320 Uncharacterized protein family UPF0067 signature. 282458008314 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 282458008315 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 282458008316 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 282458008317 RNA binding surface [nucleotide binding]; other site 282458008318 Pfam match to entry PF00163 Ribosomal_S4, Ribosomal protein S4/S9 N-terminal domain, score 112.20, E-value 9.9e-30 282458008319 Pfam match to entry PF01479 S4, S4 domain, score 89.10, E-value 9.1e-23 282458008320 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 282458008321 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 282458008322 active site 282458008323 catalytic site [active] 282458008324 OsmC-like protein; Region: OsmC; cl00767 282458008325 Pfam match to entry PF02566 OsmC, OsmC-like protein, score 58.50, E-value 1.5e-13 282458008326 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 282458008327 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282458008328 catalytic residue [active] 282458008329 Pfam match to entry PF00266 aminotran_5, Aminotransferase class-V, score 61.00, E-value 2.6e-14 282458008330 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 282458008331 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 282458008332 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 282458008333 ligand binding site [chemical binding]; other site 282458008334 NAD binding site [chemical binding]; other site 282458008335 dimerization interface [polypeptide binding]; other site 282458008336 catalytic site [active] 282458008337 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 282458008338 putative L-serine binding site [chemical binding]; other site 282458008339 Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 42.70, E-value 8.1e-09 282458008340 Pfam match to entry PF02826 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 219.50, E-value 4.9e-62 282458008341 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 282458008342 Pfam match to entry PF01842 ACT, ACT domain, score 43.60, E-value 4.5e-09 282458008343 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 282458008344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458008345 motif II; other site 282458008346 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 11.50, E-value 0.023 282458008347 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 282458008348 Signal peptide predicted for SAR1803 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.969 between residues 37 and 38; signal peptide 282458008349 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282458008350 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282458008351 active site turn [active] 282458008352 phosphorylation site [posttranslational modification] 282458008353 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 50.90, E-value 3.9e-13 282458008354 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282458008355 11 probable transmembrane helices predicted for SAR1803 by TMHMM2.0 at aa 15-37, 44-66, 76-93, 114-133, 153-175, 187-206, 241-263, 276-293, 298-320, 325-342 and 352-374 282458008356 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 327.20, E-value 1.9e-94 282458008357 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 282458008358 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 282458008359 putative acyl-acceptor binding pocket; other site 282458008360 Pfam match to entry PF01553 Acyltransferase, Acyltransferase, score 102.20, E-value 1e-26 282458008361 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 282458008362 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 282458008363 protein binding site [polypeptide binding]; other site 282458008364 1 probable transmembrane helix predicted for SAR1805 by TMHMM2.0 at aa 27-49 282458008365 Pfam match to entry PF00089 trypsin, Trypsin, score 70.10, E-value 2.2e-21 282458008366 Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF)., score 19.80, E-value 0.012 282458008367 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 282458008368 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 282458008369 active site 282458008370 HIGH motif; other site 282458008371 dimer interface [polypeptide binding]; other site 282458008372 KMSKS motif; other site 282458008373 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 282458008374 RNA binding surface [nucleotide binding]; other site 282458008375 Pfam match to entry PF01479 S4, S4 domain, score 19.60, E-value 0.018 282458008376 Pfam match to entry PF00579 tRNA-synt_1b, tRNA synthetases class I (W and Y), score 389.90, E-value 2.5e-113 282458008377 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282458008378 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 282458008379 Transglycosylase; Region: Transgly; pfam00912 282458008380 1 probable transmembrane helix predicted for SAR1807 by TMHMM2.0 at aa 27-49 282458008381 Pfam match to entry PF00912 Transglycosyl, Transglycosylase, score 166.90, E-value 3.4e-46 282458008382 Similar to Staphylococcus aureus serine-aspartate repeat family protein SdrC TR:O86487 (EMBL:AJ005645) (947 aa) fasta scores: E(): 0.064, 20.52% id in 955 aa, and to the C-terminal region of Staphylococcus aureus bone sialoprotein-binding protein Bbp TR:Q9KWX6 (EMBL:Y18653) (1171 aa) fasta scores: E(): 0.03, 21.55% id in 965 aa. Probable LPXTG-sorted surface protein. Contains a nonsense mutation (ochre) after codon 278;haptoglobin-binding surface anchored protein (pseudogene) 282458008383 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282458008384 Signal peptide predicted for SAR1809 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 40 and 41 282458008385 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 282458008386 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 282458008387 Potassium binding sites [ion binding]; other site 282458008388 Cesium cation binding sites [ion binding]; other site 282458008389 Pfam match to entry PF01268 FTHFS, Formate--tetrahydrofolate ligase, score 1067.50, E-value 0 282458008390 PS00722 Formate--tetrahydrofolate ligase signature 2. 282458008391 acetyl-CoA synthetase; Provisional; Region: PRK04319 282458008392 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 282458008393 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 282458008394 active site 282458008395 acyl-activating enzyme (AAE) consensus motif; other site 282458008396 putative CoA binding site [chemical binding]; other site 282458008397 AMP binding site [chemical binding]; other site 282458008398 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 417.50, E-value 1.2e-121 282458008399 PS00455 AMP-binding domain signature. 282458008400 1 probable transmembrane helix predicted for SAR1811 by TMHMM2.0 at aa 112-134 282458008401 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 282458008402 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 282458008403 active site 282458008404 Zn binding site [ion binding]; other site 282458008405 Pfam match to entry PF00850 Hist_deacetyl, Histone deacetylase, score 453.50, E-value 1.7e-132 282458008406 catabolite control protein A; Region: ccpA; TIGR01481 282458008407 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 282458008408 DNA binding site [nucleotide binding] 282458008409 domain linker motif; other site 282458008410 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 282458008411 dimerization interface [polypeptide binding]; other site 282458008412 effector binding site; other site 282458008413 Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family., score 21.00, E-value 1.1e-05 282458008414 Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, score 50.30, E-value 8e-13 282458008415 Predicted helix-turn-helix motif with score 1741 (+5.12 SD) at aa 3-24, sequence VTIYDVAREARVSMATVSRVVN 282458008416 PS00356 Bacterial regulatory proteins, lacI family signature. 282458008417 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 282458008418 Chorismate mutase type II; Region: CM_2; cl00693 282458008419 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 282458008420 Pfam match to entry PF00793 DAHP_synth_1, DAHP synthetase I family, score 437.10, E-value 1.5e-127 282458008421 Pfam match to entry PF01817 Chorismate_mut, Chorismate mutase, score 64.20, E-value 2.8e-15 282458008422 1 probable transmembrane helix predicted for SAR1816 by TMHMM2.0 at aa 28-45 282458008423 Signal peptide predicted for SAR1817 by SignalP 2.0 HMM (Signal peptide probabilty 0.719) with cleavage site probability 0.289 between residues 28 and 29; signal peptide 282458008424 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 282458008425 1 probable transmembrane helix predicted for SAR1817 by TMHMM2.0 at aa 4-26 282458008426 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 282458008427 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 282458008428 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 282458008429 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 282458008430 Pfam match to entry PF02875 Mur_ligase_C, Mur ligase, glutamate ligase domain, score 100.80, E-value 2.6e-26 282458008431 Pfam match to entry PF01225 Mur_ligase, Mur ligase, catalytic domain, score 220.50, E-value 3.3e-64 282458008432 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 282458008433 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 282458008434 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 282458008435 Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family, score 274.40, E-value 1.4e-78 282458008436 PS00017 ATP/GTP-binding site motif A (P-loop). 282458008437 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 282458008438 putative tRNA-binding site [nucleotide binding]; other site 282458008439 Pfam match to entry PF01588 tRNA_bind, tRNA binding domain, score 66.20, E-value 7e-16 282458008440 hypothetical protein; Provisional; Region: PRK13668 282458008441 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 282458008442 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 282458008443 catalytic residues [active] 282458008444 Pfam match to entry PF00085 thiored, Thioredoxin, score 26.90, E-value 9.1e-07 282458008445 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 282458008446 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 282458008447 oligomer interface [polypeptide binding]; other site 282458008448 active site 282458008449 metal binding site [ion binding]; metal-binding site 282458008450 Predicted small secreted protein [Function unknown]; Region: COG5584 282458008451 1 probable transmembrane helix predicted for SAR1824 by TMHMM2.0 at aa 6-28 282458008452 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 282458008453 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 8.20, E-value 0.00061 282458008454 Tn552 282458008455 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 282458008456 PS00017 ATP/GTP-binding site motif A (P-loop). 282458008457 Helix-turn-helix domain; Region: HTH_28; pfam13518 282458008458 Winged helix-turn helix; Region: HTH_29; pfam13551 282458008459 Integrase core domain; Region: rve; pfam00665 282458008460 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 282458008461 Pfam match to entry PF00665 rve, Integrase core domain, score 113.40, E-value 1.4e-31 282458008462 Predicted helix-turn-helix motif with score 1319 (+3.68 SD) at aa 34-55, sequence QSLSSISKSKGIALSTLYRWNK 282458008463 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 282458008464 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 282458008465 catalytic residues [active] 282458008466 catalytic nucleophile [active] 282458008467 Presynaptic Site I dimer interface [polypeptide binding]; other site 282458008468 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 282458008469 Synaptic Flat tetramer interface [polypeptide binding]; other site 282458008470 Synaptic Site I dimer interface [polypeptide binding]; other site 282458008471 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 282458008472 DNA-binding interface [nucleotide binding]; DNA binding site 282458008473 Pfam match to entry PF02796 HTH_7, Helix-turn-helix domain of resolvase, score 73.10, E-value 5.8e-18 282458008474 Predicted helix-turn-helix motif with score 1887 (+5.61 SD) at aa 161-182, sequence TPIKTIAEQWQVSRTTIYRYLN 282458008475 Pfam match to entry PF00239 resolvase, Resolvase class of site-specific recombinases, score 289.10, E-value 1.1e-85 282458008476 PS00398 Site-specific recombinases signature 2. 282458008477 PS00397 Site-specific recombinases active site. 282458008478 Predicted transcriptional regulator [Transcription]; Region: COG3682 282458008479 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 282458008480 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 282458008481 Pfam match to entry PF00144 beta-lactamase, Beta-lactamase, score 164.20, E-value 2.1e-45 282458008482 6 probable transmembrane helices predicted for SAR1830 by TMHMM2.0 at aa 4-26, 38-60, 105-127, 171-191, 211-233 and 309-331 282458008483 Signal peptide predicted for SAR1831 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 24 and 25; signal peptide 282458008484 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 282458008485 beta-lactamase TEM; Provisional; Region: PRK15442 282458008486 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 282458008487 Pfam match to entry PF00144 beta-lactamase, Beta-lactamase, score 382.10, E-value 5.6e-111 282458008488 PS00146 Beta-lactamase class-A active site. 282458008489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458008490 S-adenosylmethionine binding site [chemical binding]; other site 282458008491 Pfam match to entry PF02390 Methyltransf_4, methyltransferase, score 205.70, E-value 7e-58 282458008492 Phosphotransferase enzyme family; Region: APH; pfam01636 282458008493 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 282458008494 active site 282458008495 substrate binding site [chemical binding]; other site 282458008496 ATP binding site [chemical binding]; other site 282458008497 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 282458008498 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 282458008499 homodimer interface [polypeptide binding]; other site 282458008500 substrate-cofactor binding pocket; other site 282458008501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458008502 catalytic residue [active] 282458008503 Pfam match to entry PF01063 aminotran_4, Aminotransferase class IV, score 402.00, E-value 5.8e-117 282458008504 PS00770 Aminotransferases class-IV signature. 282458008505 dipeptidase PepV; Reviewed; Region: PRK07318 282458008506 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 282458008507 active site 282458008508 metal binding site [ion binding]; metal-binding site 282458008509 Pfam match to entry PF01546 Peptidase_M20, Peptidase M20/M25/M40, score 11.10, E-value 0.029 282458008510 Pfam match to entry PF01546 Peptidase_M20, Peptidase M20/M25/M40, score 114.70, E-value 5.7e-32 282458008511 Signal peptide predicted for SAR1837 by SignalP 2.0 HMM (Signal peptide probabilty 0.802) with cleavage site probability 0.434 between residues 24 and 25; signal peptide 282458008512 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 282458008513 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 282458008514 RNA binding surface [nucleotide binding]; other site 282458008515 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 282458008516 active site 282458008517 uracil binding [chemical binding]; other site 282458008518 Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase, score 62.10, E-value 1.2e-14 282458008519 PS01149 Rsu family of pseudouridine synthase signature. 282458008520 Pfam match to entry PF01479 S4, S4 domain, score 40.50, E-value 3.9e-08 282458008521 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 282458008522 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 282458008523 14 probable transmembrane helices predicted for SAR1839 by TMHMM2.0 at aa 12-34, 49-71, 91-113, 133-155, 176-198, 202-221, 250-267, 303-322, 342-364, 388-410, 417-439, 443-462, 475-497 and 507-529 282458008524 Pfam match to entry PF01943 Polysacc_synt, Polysaccharide biosynthesis protein, score 57.70, E-value 2.6e-13 282458008525 Signal peptide predicted for SAR1840 by SignalP 2.0 HMM (Signal peptide probabilty 0.662) with cleavage site probability 0.260 between residues 20 and 21; signal peptide 282458008526 HI0933-like protein; Region: HI0933_like; pfam03486 282458008527 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 282458008528 Signal peptide predicted for SAR1841 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.760 between residues 37 and 38; signal peptide 282458008529 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282458008530 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 282458008531 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458008532 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458008533 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458008534 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458008535 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458008536 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458008537 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458008538 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458008539 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458008540 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458008541 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458008542 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458008543 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282458008544 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 18.40, E-value 0.17 282458008545 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282458008546 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 282458008547 active site residue [active] 282458008548 Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain, score 41.40, E-value 2.1e-08 282458008549 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 282458008550 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 282458008551 HIGH motif; other site 282458008552 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 282458008553 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 282458008554 active site 282458008555 KMSKS motif; other site 282458008556 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 282458008557 tRNA binding surface [nucleotide binding]; other site 282458008558 Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V), score 785.00, E-value 3e-232 282458008559 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282458008560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458008561 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282458008562 putative substrate translocation pore; other site 282458008563 12 probable transmembrane helices predicted for SAR1844 by TMHMM2.0 at aa 7-25, 40-62, 69-91, 96-118, 131-153, 159-181, 202-224, 244-266, 275-292, 297-319, 332-354 and 364-381 282458008564 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 282458008565 Methyltransferase domain; Region: Methyltransf_31; pfam13847 282458008566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458008567 S-adenosylmethionine binding site [chemical binding]; other site 282458008568 PS00430 TonB-dependent receptor proteins signature 1. 282458008569 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282458008570 1 probable transmembrane helix predicted for SAR1847 by TMHMM2.0 at aa 5-27 282458008571 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 282458008572 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 282458008573 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 282458008574 Pfam match to entry PF01619 Pro_dh, Proline dehydrogenase, score 208.20, E-value 1.2e-58 282458008575 1 probable transmembrane helix predicted for SAR1849 by TMHMM2.0 at aa 310-327 282458008576 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 282458008577 homopentamer interface [polypeptide binding]; other site 282458008578 active site 282458008579 Pfam match to entry PF00885 DMRL_synthase, 6,7-dimethyl-8-ribityllumazine synthase, score 286.20, E-value 4.2e-82 282458008580 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 282458008581 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 282458008582 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 282458008583 dimerization interface [polypeptide binding]; other site 282458008584 active site 282458008585 Pfam match to entry PF00925 GTP_cyclohydro2, GTP cyclohydrolase II, score 269.40, E-value 4.6e-77 282458008586 Pfam match to entry PF00926 DHBP_synthase, 3,4-dihydroxy-2-butanone 4-phosphate synthase, score 359.70, E-value 3.2e-104 282458008587 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 282458008588 Lumazine binding domain; Region: Lum_binding; pfam00677 282458008589 Lumazine binding domain; Region: Lum_binding; pfam00677 282458008590 Pfam match to entry PF00677 Lum_binding, Lumazine binding domain, score 88.90, E-value 1e-22 282458008591 Pfam match to entry PF00677 Lum_binding, Lumazine binding domain, score 70.30, E-value 4.1e-17 282458008592 PS00430 TonB-dependent receptor proteins signature 1. 282458008593 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 282458008594 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 282458008595 catalytic motif [active] 282458008596 Zn binding site [ion binding]; other site 282458008597 RibD C-terminal domain; Region: RibD_C; cl17279 282458008598 Pfam match to entry PF01872 RibD_C, RibD C-terminal domain, score 125.40, E-value 1e-33 282458008599 Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region, score 97.90, E-value 2e-25 282458008600 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 282458008601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 282458008602 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 282458008603 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 282458008604 dimerization interface [polypeptide binding]; other site 282458008605 putative DNA binding site [nucleotide binding]; other site 282458008606 putative Zn2+ binding site [ion binding]; other site 282458008607 Pfam match to entry PF01022 HTH_5, Bacterial regulatory protein, arsR family, score 96.00, E-value 7.4e-25 282458008608 Predicted helix-turn-helix motif with score 997 (+2.58 SD) at aa 30-51, sequence LCACDLLEHFQFSQPTLSYHMK 282458008609 PS00846 Bacterial regulatory proteins, arsR family signature. 282458008610 Signal peptide predicted for SAR1856 by SignalP 2.0 HMM (Signal peptide probabilty 0.839) with cleavage site probability 0.352 between residues 34 and 35; signal peptide 282458008611 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 282458008612 arsenical pump membrane protein; Provisional; Region: PRK15445 282458008613 transmembrane helices; other site 282458008614 11 probable transmembrane helices predicted for SAR1856 by TMHMM2.0 at aa 2-19, 24-46, 53-72, 98-120, 141-163, 178-200, 221-243, 248-265, 285-307, 317-336 and 407-429 282458008615 Pfam match to entry PF02040 ArsB, Arsenical pump membrane protein, score 965.10, E-value 1.8e-286 282458008616 Signal peptide predicted for SAR1857 by SignalP 2.0 HMM (Signal peptide probabilty 0.974) with cleavage site probability 0.344 between residues 37 and 38; signal peptide 282458008617 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 282458008618 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 282458008619 Pfam match to entry PF01832 Amidase_4, N-acetylmuramoyl-L-alanine amidase, score 103.60, E-value 4e-27 282458008620 1 probable transmembrane helix predicted for SAR1857 by TMHMM2.0 at aa 7-29 282458008621 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 282458008622 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 282458008623 DNA binding residues [nucleotide binding] 282458008624 Predicted helix-turn-helix motif with score 1485 (+4.24 SD) at aa 124-145, sequence YKQYEIADIMSLSTSTIKLIKA 282458008625 2 probable transmembrane helices predicted for SAR1861 by TMHMM2.0 at aa 64-86 and 106-128 282458008626 CAAX protease self-immunity; Region: Abi; pfam02517 282458008627 7 probable transmembrane helices predicted for SAR1862 by TMHMM2.0 at aa 17-39, 44-63, 76-95, 115-134, 141-161, 166-185 and 192-210 282458008628 Pfam match to entry PF02517 Abi, CAAX amino terminal protease, score 77.20, E-value 3.4e-19 282458008629 CAAX protease self-immunity; Region: Abi; pfam02517 282458008630 6 probable transmembrane helices predicted for SAR1863 by TMHMM2.0 at aa 20-37, 47-69, 76-98, 118-140, 147-162 and 167-186 282458008631 Pfam match to entry PF02517 Abi, CAAX amino terminal protease, score 52.80, E-value 7.5e-12 282458008632 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 282458008633 active site 282458008634 intersubunit interactions; other site 282458008635 catalytic residue [active] 282458008636 Pfam match to entry PF00923 Transaldolase, Transaldolase, score 58.00, E-value 1.4e-16 282458008637 Signal peptide predicted for SAR1865 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.765 between residues 28 and 29; signal peptide 282458008638 3 probable transmembrane helices predicted for SAR1865 by TMHMM2.0 at aa 7-29, 34-56 and 77-99 282458008639 camphor resistance protein CrcB; Provisional; Region: PRK14201 282458008640 4 probable transmembrane helices predicted for SAR1866 by TMHMM2.0 at aa 24-46, 59-81, 91-113 and 118-140 282458008641 Pfam match to entry PF02537 CRCB, CrcB-like protein, score 102.30, E-value 9.4e-27 282458008642 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 282458008643 Signal peptide predicted for SAR1867 by SignalP 2.0 HMM (Signal peptide probabilty 0.610) with cleavage site probability 0.353 between residues 20 and 21; signal peptide 282458008644 Pfam match to entry PF02537 CRCB, CrcB-like protein, score 81.40, E-value 1.8e-20 282458008645 4 probable transmembrane helices predicted for SAR1867 by TMHMM2.0 at aa 4-21, 33-54, 58-80 and 93-115 282458008646 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 282458008647 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 282458008648 active site 282458008649 catalytic tetrad [active] 282458008650 Pfam match to entry PF00248 aldo_ket_red, Aldo/keto reductase, score 404.70, E-value 9.2e-120 282458008651 PS00063 Aldo/keto reductase active site signature. 282458008652 Predicted helix-turn-helix motif for SAR1868 with score 1298.000, SD 3.61 at aa 202-223, sequence ETIKDIAQELGKSPAQVVLRWN 282458008653 PS00062 Aldo/keto reductase signature 2. 282458008654 PS00798 Aldo/keto reductase signature 1. 282458008655 Signal peptide predicted for SAR1869 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.423 between residues 38 and 39; signal peptide 282458008656 1 probable transmembrane helix predicted for SAR1869 by TMHMM2.0 at aa 10-32 282458008657 S-adenosylmethionine synthetase; Validated; Region: PRK05250 282458008658 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 282458008659 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 282458008660 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 282458008661 Pfam match to entry PF02773 S-AdoMet_syntD3, S-adenosylmethionine synthetase, C-terminal domain, score 317.70, E-value 1.3e-91 282458008662 PS00377 S-adenosylmethionine synthetase signature 2. 282458008663 Pfam match to entry PF02772 S-AdoMet_syntD2, S-adenosylmethionine synthetase, central domain, score 299.80, E-value 3.2e-86 282458008664 PS00376 S-adenosylmethionine synthetase signature 1. 282458008665 Pfam match to entry PF00438 S-AdoMet_synt, S-adenosylmethionine synthetase, N-terminal domain, score 212.30, E-value 7.1e-62 282458008666 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 282458008667 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 282458008668 active site 282458008669 substrate-binding site [chemical binding]; other site 282458008670 metal-binding site [ion binding] 282458008671 ATP binding site [chemical binding]; other site 282458008672 Pfam match to entry PF01293 PEPCK_ATP, Phosphoenolpyruvate carboxykinase, score 1212.70, E-value 0 282458008673 PS00017 ATP/GTP-binding site motif A (P-loop). 282458008674 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 282458008675 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 282458008676 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 282458008677 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 282458008678 nudix motif; other site 282458008679 Pfam match to entry PF00293 NUDIX, MutT-like domain, score 34.80, E-value 2e-06 282458008680 PS00893 mutT domain signature. 282458008681 Haemolytic domain; Region: Haemolytic; pfam01809 282458008682 Pfam match to entry PF01809 DUF37, Domain of unknown function DUF37, score 145.50, E-value 9.3e-40 282458008683 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 282458008684 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 282458008685 metal binding site [ion binding]; metal-binding site 282458008686 substrate binding pocket [chemical binding]; other site 282458008687 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 282458008688 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 282458008689 acyl-activating enzyme (AAE) consensus motif; other site 282458008690 putative AMP binding site [chemical binding]; other site 282458008691 putative active site [active] 282458008692 putative CoA binding site [chemical binding]; other site 282458008693 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 286.60, E-value 3.1e-82 282458008694 Signal peptide predicted for SAR1878 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.321 between residues 35 and 36; signal peptide 282458008695 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458008696 Signal peptide predicted for SAR1879 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.319 between residues 29 and 30; signal peptide 282458008697 Excalibur calcium-binding domain; Region: Excalibur; smart00894 282458008698 1 probable transmembrane helix predicted for SAR1879 by TMHMM2.0 at aa 5-27 282458008699 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458008700 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 282458008701 1 probable transmembrane helix predicted for SAR1880 by TMHMM2.0 at aa 39-61 282458008702 Signal peptide predicted for SAR1881 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.331 between residues 28 and 29; signal peptide 282458008703 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458008704 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 282458008705 FRG domain; Region: FRG; pfam08867 282458008706 Domain of unknown function (DUF955); Region: DUF955; pfam06114 282458008707 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282458008708 Signal peptide predicted for SAR1886 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.796 between residues 23 and 24; signal peptide 282458008709 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 282458008710 1 probable transmembrane helix predicted for SAR1886 by TMHMM2.0 at aa 5-24 282458008711 N-terminus is similar to the N-terminal region of Enterococcus faecium insertion sequence IS1485 hypothetical protein TR:O31104 (EMBL:AF029727) (96 aa) fasta scores: E(): 0.0023, 62.5% id in 40 aa. Contains a frameshift after codon 9 and a nonsense mutation (ochre) after codon 20; transposase (fragment) 282458008712 Signal peptide predicted for SAR1889 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.414 between residues 26 and 27; signal peptide 282458008713 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 282458008714 1 probable transmembrane helix predicted for SAR1889 by TMHMM2.0 at aa 7-24 282458008715 Signal peptide predicted for SAR1890 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.418 between residues 24 and 25; signal peptide 282458008716 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 282458008717 1 probable transmembrane helix predicted for SAR1890 by TMHMM2.0 at aa 7-24 282458008718 No significant database matches. Contains a frameshift after codon 39. Similar to SAR1894, 90.566% identity (90.566% ungapped) in 106 aa overlap, SAR1886, 68.224% identity (68.868% ungapped) in 107 aa overlap, SAR1889, 62.264% identity (62.264% ungapped) in 106 aa overlap, and to SAR1890, 61.321% identity (61.321% ungapped) in 106 aa overlap; exported protein (pseudogene) 282458008719 1 probable transmembrane helix predicted for SAR1891 by TMHMM2.0 at aa 5-24 282458008720 Signal peptide predicted for SAR1891 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.608 between residues 23 and 24 282458008721 Signal peptide predicted for SAR1892 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.821 between residues 30 and 31; signal peptide 282458008722 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 282458008723 substrate binding site [chemical binding]; other site 282458008724 catalytic residues [active] 282458008725 Pfam match to entry PF02278 Lyase_8, Polysaccharide lyase 8, super-sandwich domain, score 451.30, E-value 8.3e-132 282458008726 Pfam match to entry PF02884 Lyase_8_C, Polysaccharide lyase 8, C-terminal beta-sandwich domain, score 90.50, E-value 3.4e-23 282458008727 Signal peptide predicted for SAR1893 by SignalP 2.0 HMM (Signal peptide probabilty 0.702) with cleavage site probability 0.305 between residues 23 and 24; signal peptide 282458008728 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 282458008729 1 probable transmembrane helix predicted for SAR1893 by TMHMM2.0 at aa 5-22 282458008730 Signal peptide predicted for SAR1894 by SignalP 2.0 HMM (Signal peptide probabilty 0.811) with cleavage site probability 0.789 between residues 28 and 29; signal peptide 282458008731 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 282458008732 1 probable transmembrane helix predicted for SAR1894 by TMHMM2.0 at aa 7-26 282458008733 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 282458008734 nucleophilic elbow; other site 282458008735 catalytic triad; other site 282458008736 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 282458008737 PS00017 ATP/GTP-binding site motif A (P-loop). 282458008738 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 282458008739 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 282458008740 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 282458008741 Pfam match to entry PF01420 Methylase_S, Type I restriction modification DNA specificity domain, score 86.70, E-value 7.4e-24 282458008742 Pfam match to entry PF01420 Methylase_S, Type I restriction modification DNA specificity domain, score 54.10, E-value 2e-14 282458008743 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 282458008744 HsdM N-terminal domain; Region: HsdM_N; pfam12161 282458008745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458008746 S-adenosylmethionine binding site [chemical binding]; other site 282458008747 Pfam match to entry PF02384 N6_Mtase, N-6 DNA Methylase, score 262.50, E-value 5.8e-75 282458008748 PS00092 N-6 Adenine-specific DNA methylases signature. 282458008749 Pfam match to entry PF02506 Methylase_M, Type I restriction modification system, M protein, score 264.80, E-value 1.2e-75 282458008750 Similar to Staphylococcus aureus serine protease SplF TR:Q9KH46 (EMBL:AF271715) (239 aa) fasta scores: E(): 3.4e-84, 97.9% id in 239 aa. Contains a nonsense mutation (ochre) after codon 41. Similar to SAR1902, 64.481% identity (64.835% ungapped) in 183 aa overlap, and to SAR1905, 50.820% identity (51.099% ungapped) in 183 aa overlap;serine protease (pseudogene) 282458008751 Pfam match to entry PF00089 trypsin, Trypsin, score 49.80, E-value 6.1e-15 282458008752 PS00672 Serine proteases, V8 family, histidine active site. 282458008753 2 probable transmembrane helices predicted for SAR1900 by TMHMM2.0 at aa 5-27 and 47-69 282458008754 Signal peptide predicted for SAR1900 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.829 between residues 36 and 37 282458008755 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 282458008756 Signal peptide predicted for SAR1902 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.866 between residues 36 and 37; signal peptide 282458008757 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 282458008758 Pfam match to entry PF00089 trypsin, Trypsin, score 59.20, E-value 6.3e-18 282458008759 PS00672 Serine proteases, V8 family, histidine active site. 282458008760 1 probable transmembrane helix predicted for SAR1902 by TMHMM2.0 at aa 5-27 282458008761 Similar to Staphylococcus aureus serine protease SplE TR:Q9KH47 (EMBL:AF271715) (238 aa) fasta scores: E(): 6.3e-58, 64.7% id in 238 aa. Contains a frameshift after codon 103. Frameshift occurs at a poly A heptamer;serine protease (pseudogene) 282458008762 PS00672 Serine proteases, V8 family, histidine active site. 282458008763 Signal peptide predicted for SAR1903 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.915 between residues 36 and 37 282458008764 1 probable transmembrane helix predicted for SAR1903 by TMHMM2.0 at aa 5-27 282458008765 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 282458008766 Signal peptide predicted for SAR1905 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.865 between residues 36 and 37; signal peptide 282458008767 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 282458008768 Pfam match to entry PF00089 trypsin, Trypsin, score 56.20, E-value 5.5e-17 282458008769 PS00672 Serine proteases, V8 family, histidine active site. 282458008770 1 probable transmembrane helix predicted for SAR1905 by TMHMM2.0 at aa 5-27 282458008771 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 282458008772 Signal peptide predicted for SAR1906 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.423 between residues 36 and 37; signal peptide 282458008773 Pfam match to entry PF00089 trypsin, Trypsin, score 95.20, E-value 2.2e-29 282458008774 PS00672 Serine proteases, V8 family, histidine active site. 282458008775 1 probable transmembrane helix predicted for SAR1906 by TMHMM2.0 at aa 5-27 282458008776 Similar to the C-terminal region of Staphylococcus aureus serine protease SplB TR:Q9KH50 (EMBL:AF271715) (240 aa) fasta scores: E(): 3.4e-15, 97.67% id in 43 aa. Similar to the C-terminal regions of SAR1903, 58.140% identity (58.140% ungapped) in 43 aa overlap, and SAR1902, 53.488% identity (53.488% ungapped) in 43 aa overlap;serine protease (fragment) 282458008777 4 probable transmembrane helices predicted for SAR1910 by TMHMM2.0 at aa 25-47, 62-84, 97-115 and 125-142 282458008778 Signal peptide predicted for SAR1911 by SignalP 2.0 HMM (Signal peptide probabilty 0.961) with cleavage site probability 0.558 between residues 29 and 30; signal peptide 282458008779 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 282458008780 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 282458008781 1 probable transmembrane helix predicted for SAR1911 by TMHMM2.0 at aa 13-35 282458008782 Similar to internal regions of Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBM9 (EMBL:AB044554) (328 aa) fasta scores: E(): 1.2e-16, 78.12% id in 64 aa, and Bacillus halodurans transposase BH3503 TR:Q9JWR3 (EMBL:AP001520) (314 aa) fasta scores: E(): 9.1e-05, 48.38% id in 62 aa. Probable gene remnant. Similar to an internal regions of SAR0085, 78.125% identity (78.125% ungapped) in 64 aa overlap, SAR0955, 78.125% identity (78.125% ungapped) in 64 aa overlap, SAR1305, 78.125% identity (78.125% ungapped) in 64 aa overlap, SAR1170, 78.125% identity (78.125% ungapped) in 64 aa overlap, SAR1433, 78.125% identity (78.125% ungapped) in 64 aa overlap, and SAR2705, 78.125% identity (78.125% ungapped) in 64 aa overlap;transposase (fragment) 282458008783 Predicted helix-turn-helix motif with score 1057 (+2.79 SD) at aa 8-29, sequence YSLRPIARKLDRSASTILREIS 282458008784 Poor database matches. Similar to Plasmodium falciparum hypothetical protein PFB0820c TR:O96256 (EMBL:AE001419) (273 aa) fasta scores: E(): 0.73, 22.35% id in 255 aa. Contains a nonsense mutation (amber) after codon 104. Similar to Staphylococcus aureus subsp aureus Mu50 hypothetical protein SAV1823 TR:BAB57985 (EMBL:AP003363) (258 aa) fasta scores: E(): 6.4e-88, 97.28% id in 258 aa, and to Staphylococcus aureus subsp aureus N315 hypothetical protein SA1641 TR:Q99T50 (EMBL:AP003135) (258 aa) fasta scores: E(): 6.4e-88, 97.28% id in 258 aa;hypothetical protein (pseudogene) 282458008785 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 282458008786 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458008787 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 136.50, E-value 4.9e-37 282458008788 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458008789 Pfam match to entry PF01123 Stap_Strp_toxin, Staphylococcal/Streptococcal toxin, OB-fold domain, score 75.50, E-value 1.1e-18 282458008790 Signal peptide predicted for SAR1917 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.988 between residues 24 and 25; signal peptide 282458008791 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 282458008792 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458008793 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 87.20, E-value 3.3e-22 282458008794 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458008795 PS00277 Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin signature 1. 282458008796 Pfam match to entry PF01123 Stap_Strp_toxin, Staphylococcal/Streptococcal toxin, OB-fold domain, score 68.70, E-value 1.2e-16 282458008797 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 282458008798 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458008799 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 195.50, E-value 8.4e-55 282458008800 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458008801 PS00277 Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin signature 1. 282458008802 Pfam match to entry PF01123 Stap_Strp_toxin, Staphylococcal/Streptococcal toxin, OB-fold domain, score 144.20, E-value 2.3e-39 282458008803 Signal peptide predicted for SAR1919 by SignalP 2.0 HMM (Signal peptide probabilty 0.648) with cleavage site probability 0.376 between residues 24 and 25; signal peptide 282458008804 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 282458008805 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458008806 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 98.10, E-value 1.7e-25 282458008807 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458008808 Pfam match to entry PF01123 Stap_Strp_toxin, Staphylococcal/Streptococcal toxin, OB-fold domain, score -14.50, E-value 0.84 282458008809 Signal peptide predicted for SAR1920 by SignalP 2.0 HMM (Signal peptide probabilty 0.876) with cleavage site probability 0.779 between residues 22 and 23; signal peptide 282458008810 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 282458008811 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458008812 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 107.60, E-value 2.4e-28 282458008813 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458008814 Pfam match to entry PF01123 Stap_Strp_toxin, Staphylococcal/Streptococcal toxin, OB-fold domain, score 9.50, E-value 0.0046 282458008815 Signal peptide predicted for SAR1921 by SignalP 2.0 HMM (Signal peptide probabilty 0.969) with cleavage site probability 0.958 between residues 22 and 23; signal peptide 282458008816 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 282458008817 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458008818 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 110.80, E-value 2.6e-29 282458008819 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458008820 PS00277 Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin signature 1. 282458008821 Pfam match to entry PF01123 Stap_Strp_toxin, Staphylococcal/Streptococcal toxin, OB-fold domain, score 69.10, E-value 9.7e-17 282458008822 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 282458008823 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 282458008824 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 282458008825 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 282458008826 Pfam match to entry PF01593 Amino_oxidase, Flavin containing amine oxidase, score -103.40, E-value 0.00088 282458008827 ferrochelatase; Provisional; Region: PRK12435 282458008828 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 282458008829 C-terminal domain interface [polypeptide binding]; other site 282458008830 active site 282458008831 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 282458008832 active site 282458008833 N-terminal domain interface [polypeptide binding]; other site 282458008834 Pfam match to entry PF00762 Ferrochelatase, Ferrochelatase, score 291.30, E-value 1.2e-83 282458008835 PS00435 Peroxidases proximal heme-ligand signature. 282458008836 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 282458008837 substrate binding site [chemical binding]; other site 282458008838 active site 282458008839 Pfam match to entry PF01208 URO-D, Uroporphyrinogen decarboxylase (URO-D), score 537.70, E-value 8.1e-158 282458008840 PS00907 Uroporphyrinogen decarboxylase signature 2. 282458008841 PS00906 Uroporphyrinogen decarboxylase signature 1. 282458008842 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 282458008843 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 282458008844 9 probable transmembrane helices predicted for SAR1927 by TMHMM2.0 at aa 26-48, 58-80, 101-123, 133-151, 164-183, 187-204, 287-321, 352-371 and 376-395 282458008845 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 282458008846 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 282458008847 Walker A/P-loop; other site 282458008848 ATP binding site [chemical binding]; other site 282458008849 Q-loop/lid; other site 282458008850 ABC transporter signature motif; other site 282458008851 Walker B; other site 282458008852 D-loop; other site 282458008853 H-loop/switch region; other site 282458008854 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 178.00, E-value 1.5e-49 282458008855 PS00211 ABC transporters family signature. 282458008856 PS00017 ATP/GTP-binding site motif A (P-loop). 282458008857 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 282458008858 HIT family signature motif; other site 282458008859 catalytic residue [active] 282458008860 Pfam match to entry PF01230 HIT, HIT family, score 146.50, E-value 4.6e-40 282458008861 PS00892 HIT family signature. 282458008862 Signal peptide predicted for SAR1930 by SignalP 2.0 HMM (Signal peptide probabilty 0.946) with cleavage site probability 0.507 between residues 24 and 25; signal peptide 282458008863 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 282458008864 1 probable transmembrane helix predicted for SAR1930 by TMHMM2.0 at aa 5-22 282458008865 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 282458008866 4 probable transmembrane helices predicted for SAR1931 by TMHMM2.0 at aa 19-41, 51-73, 105-127 and 137-159 282458008867 Signal peptide predicted for SAR1932 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.674 between residues 25 and 26; signal peptide 282458008868 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 282458008869 SurA N-terminal domain; Region: SurA_N_3; cl07813 282458008870 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 282458008871 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458008872 Pfam match to entry PF00639 Rotamase, PPIC-type PPIASE domain., score 102.90, E-value 6.3e-27 282458008873 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 282458008874 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 282458008875 generic binding surface II; other site 282458008876 generic binding surface I; other site 282458008877 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 282458008878 Zn2+ binding site [ion binding]; other site 282458008879 Mg2+ binding site [ion binding]; other site 282458008880 Pfam match to entry PF01966 HD, HD domain, score 75.60, E-value 1e-18 282458008881 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain, score 48.20, E-value 1.8e-10 282458008882 Uncharacterized conserved protein [Function unknown]; Region: COG4717 282458008883 P-loop containing region of AAA domain; Region: AAA_29; cl17516 282458008884 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 282458008885 SdpI/YhfL protein family; Region: SdpI; pfam13630 282458008886 2 probable transmembrane helices predicted for SAR1934 by TMHMM2.0 at aa 465-482 and 487-506 282458008887 PS00017 ATP/GTP-binding site motif A (P-loop). 282458008888 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 282458008889 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 282458008890 active site 282458008891 metal binding site [ion binding]; metal-binding site 282458008892 DNA binding site [nucleotide binding] 282458008893 Pfam match to entry PF02549 DNA_repair, DNA repair exonuclease, score 131.10, E-value 2e-35 282458008894 hypothetical protein; Provisional; Region: PRK13676 282458008895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 282458008896 2 probable transmembrane helices predicted for SAR1937 by TMHMM2.0 at aa 4-26 and 351-373 282458008897 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 282458008898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282458008899 non-specific DNA binding site [nucleotide binding]; other site 282458008900 salt bridge; other site 282458008901 sequence-specific DNA binding site [nucleotide binding]; other site 282458008902 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 25.20, E-value 0.0015 282458008903 Predicted helix-turn-helix motif with score 983 (+2.53 SD) at aa 23-44, sequence YTQDTMAQTIGLSKKTLVQIEK 282458008904 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 282458008905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458008906 active site 282458008907 phosphorylation site [posttranslational modification] 282458008908 intermolecular recognition site; other site 282458008909 dimerization interface [polypeptide binding]; other site 282458008910 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 282458008911 DNA binding residues [nucleotide binding] 282458008912 dimerization interface [polypeptide binding]; other site 282458008913 Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family, score 93.00, E-value 6e-24 282458008914 PS00622 Bacterial regulatory proteins, luxR family signature. 282458008915 Predicted helix-turn-helix motif with score 1251 (+3.45 SD) at aa 162-183, sequence KTNKEIAETLFVSEKTIKTHVS 282458008916 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 118.60, E-value 1.2e-31 282458008917 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 282458008918 GAF domain; Region: GAF_3; pfam13492 282458008919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 282458008920 Histidine kinase; Region: HisKA_3; pfam07730 282458008921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458008922 ATP binding site [chemical binding]; other site 282458008923 Mg2+ binding site [ion binding]; other site 282458008924 G-X-G motif; other site 282458008925 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 32.00, E-value 1.9e-07 282458008926 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 282458008927 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 282458008928 active site 282458008929 Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase, score 125.80, E-value 8.2e-34 282458008930 fumarate hydratase; Reviewed; Region: fumC; PRK00485 282458008931 Class II fumarases; Region: Fumarase_classII; cd01362 282458008932 active site 282458008933 tetramer interface [polypeptide binding]; other site 282458008934 Pfam match to entry PF00206 lyase_1, Lyase, score 661.50, E-value 4.4e-195 282458008935 Pfam match to entry PF00503 G-alpha, G-protein alpha subunit, score 14.00, E-value 0.0072 282458008936 PS00163 Fumarate lyases signature. 282458008937 3 probable transmembrane helices predicted for SAR1943 by TMHMM2.0 at aa 10-32, 66-85 and 100-122 282458008938 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 282458008939 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 282458008940 active site 282458008941 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 282458008942 Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase, score 171.10, E-value 1.8e-47 282458008943 epoxyqueuosine reductase; Region: TIGR00276 282458008944 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 282458008945 HEAT repeats; Region: HEAT_2; pfam13646 282458008946 Pfam match to entry PF00037 fer4, 4Fe-4S binding domain, score 14.40, E-value 0.015 282458008947 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 282458008948 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 282458008949 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 282458008950 Walker A/P-loop; other site 282458008951 ATP binding site [chemical binding]; other site 282458008952 Q-loop/lid; other site 282458008953 ABC transporter signature motif; other site 282458008954 Walker B; other site 282458008955 D-loop; other site 282458008956 H-loop/switch region; other site 282458008957 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 251.80, E-value 9.4e-72 282458008958 PS00211 ABC transporters family signature. 282458008959 PS00017 ATP/GTP-binding site motif A (P-loop). 282458008960 Signal peptide predicted for SAR1949 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.520 between residues 27 and 28; signal peptide 282458008961 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 282458008962 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 282458008963 substrate binding pocket [chemical binding]; other site 282458008964 membrane-bound complex binding site; other site 282458008965 hinge residues; other site 282458008966 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 282458008967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458008968 dimer interface [polypeptide binding]; other site 282458008969 conserved gate region; other site 282458008970 putative PBP binding loops; other site 282458008971 ABC-ATPase subunit interface; other site 282458008972 4 probable transmembrane helices predicted for SAR1949 by TMHMM2.0 at aa 7-28, 287-309, 334-356 and 448-470 282458008973 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 67.40, E-value 3e-16 282458008974 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282458008975 Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3, score 153.40, E-value 4e-42 282458008976 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 282458008977 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 282458008978 10 probable transmembrane helices predicted for SAR1950 by TMHMM2.0 at aa 12-34, 49-71, 78-97, 107-129, 136-158, 178-200, 207-229, 233-255, 258-280 and 309-331 282458008979 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 282458008980 metal binding site 2 [ion binding]; metal-binding site 282458008981 putative DNA binding helix; other site 282458008982 metal binding site 1 [ion binding]; metal-binding site 282458008983 dimer interface [polypeptide binding]; other site 282458008984 structural Zn2+ binding site [ion binding]; other site 282458008985 Pfam match to entry PF01475 FUR, Ferric uptake regulator family, score 190.90, E-value 2.1e-53 282458008986 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 282458008987 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 282458008988 putative ligand binding site [chemical binding]; other site 282458008989 NAD binding site [chemical binding]; other site 282458008990 catalytic site [active] 282458008991 Pfam match to entry PF02826 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 66.20, E-value 7.1e-16 282458008992 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 282458008993 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 282458008994 catalytic triad [active] 282458008995 Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family, score 101.90, E-value 1.2e-26 282458008996 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 282458008997 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 282458008998 inhibitor-cofactor binding pocket; inhibition site 282458008999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458009000 catalytic residue [active] 282458009001 Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III, score 317.60, E-value 7.6e-95 282458009002 Predicted membrane protein [Function unknown]; Region: COG4129 282458009003 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 282458009004 Signal peptide predicted for SAR1955 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.586 between residues 30 and 31; signal peptide 282458009005 4 probable transmembrane helices predicted for SAR1955 by TMHMM2.0 at aa 7-24, 57-79, 86-108 and 123-145 282458009006 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 282458009007 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 282458009008 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 282458009009 Walker A/P-loop; other site 282458009010 ATP binding site [chemical binding]; other site 282458009011 Q-loop/lid; other site 282458009012 ABC transporter signature motif; other site 282458009013 Walker B; other site 282458009014 D-loop; other site 282458009015 H-loop/switch region; other site 282458009016 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 221.60, E-value 1.2e-62 282458009017 PS00211 ABC transporters family signature. 282458009018 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009019 Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region., score 168.10, E-value 1.5e-46 282458009020 5 probable transmembrane helices predicted for SAR1956 by TMHMM2.0 at aa 19-41, 56-73, 136-158, 163-185 and 260-282 282458009021 hypothetical protein; Provisional; Region: PRK13662 282458009022 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 282458009023 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 282458009024 minor groove reading motif; other site 282458009025 helix-hairpin-helix signature motif; other site 282458009026 substrate binding pocket [chemical binding]; other site 282458009027 active site 282458009028 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 282458009029 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 282458009030 DNA binding and oxoG recognition site [nucleotide binding] 282458009031 Pfam match to entry PF00730 HhH-GPD, HhH-GPD superfamily base excision DNA repair protein, score 146.70, E-value 4e-40 282458009032 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 282458009033 Signal peptide predicted for SAR1959 by SignalP 2.0 HMM (Signal peptide probabilty 0.730) with cleavage site probability 0.346 between residues 29 and 30; signal peptide 282458009034 4 probable transmembrane helices predicted for SAR1959 by TMHMM2.0 at aa 65-87, 92-114, 127-149 and 154-171 282458009035 Signal peptide predicted for SAR1960 by SignalP 2.0 HMM (Signal peptide probabilty 0.617) with cleavage site probability 0.332 between residues 49 and 50; signal peptide 282458009036 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 282458009037 7 probable transmembrane helices predicted for SAR1960 by TMHMM2.0 at aa 29-51, 61-83, 95-117, 132-154, 166-185, 195-217 and 224-246 282458009038 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 282458009039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282458009040 Walker A/P-loop; other site 282458009041 ATP binding site [chemical binding]; other site 282458009042 Q-loop/lid; other site 282458009043 ABC transporter signature motif; other site 282458009044 Walker B; other site 282458009045 H-loop/switch region; other site 282458009046 1 probable transmembrane helix predicted for SAR1961 by TMHMM2.0 at aa 285-307 282458009047 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 282458009048 recombination regulator RecX; Provisional; Region: recX; PRK14135 282458009049 Pfam match to entry PF02631 RecX, RecX family, score 11.60, E-value 0.00019 282458009050 glycosyltransferase; Provisional; Region: PRK13481 282458009051 Transglycosylase; Region: Transgly; pfam00912 282458009052 Pfam match to entry PF00912 Transglycosyl, Transglycosylase, score 170.80, E-value 2.3e-47 282458009053 1 probable transmembrane helix predicted for SAR1964 by TMHMM2.0 at aa 42-64 282458009054 intracellular protease, PfpI family; Region: PfpI; TIGR01382 282458009055 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 282458009056 proposed catalytic triad [active] 282458009057 conserved cys residue [active] 282458009058 Pfam match to entry PF01965 ThiJ, ThiJ/PfpI family, score 213.50, E-value 3.2e-60 282458009059 Radical SAM superfamily; Region: Radical_SAM; pfam04055 282458009060 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282458009061 FeS/SAM binding site; other site 282458009062 YfkB-like domain; Region: YfkB; pfam08756 282458009063 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 282458009064 Pfam match to entry PF01662 Acyl-CoA_hydro, Cytosolic long-chain acyl-CoA thioester hydrolase, score 121.90, E-value 1.2e-32 282458009065 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 282458009066 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 282458009067 Pfam match to entry PF02073 Peptidase_M29, Thermophilic metalloprotease (M29), score 551.20, E-value 1.2e-191 282458009068 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 282458009069 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 282458009070 Low molecular weight phosphatase family; Region: LMWPc; cd00115 282458009071 active site 282458009072 Pfam match to entry PF01451 LMWPc, Low molecular weight phosphotyrosine protein phosphatase, score 134.80, E-value 1.6e-36 282458009073 Signal peptide predicted for SAR1972 by SignalP 2.0 HMM (Signal peptide probabilty 0.792) with cleavage site probability 0.460 between residues 22 and 23; signal peptide 282458009074 1 probable transmembrane helix predicted for SAR1972 by TMHMM2.0 at aa 5-22 282458009075 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 282458009076 6 probable transmembrane helices predicted for SAR1973 by TMHMM2.0 at aa 95-117, 158-180, 192-214, 234-256, 269-291 and 301-323 282458009077 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 282458009078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458009079 active site 282458009080 phosphorylation site [posttranslational modification] 282458009081 intermolecular recognition site; other site 282458009082 dimerization interface [polypeptide binding]; other site 282458009083 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 282458009084 DNA binding residues [nucleotide binding] 282458009085 dimerization interface [polypeptide binding]; other site 282458009086 Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family, score 84.30, E-value 2.5e-21 282458009087 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 131.50, E-value 1.6e-35 282458009088 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 282458009089 Signal peptide predicted for SAR1975 by SignalP 2.0 HMM (Signal peptide probabilty 0.924) with cleavage site probability 0.885 between residues 30 and 31; signal peptide 282458009090 Histidine kinase; Region: HisKA_3; pfam07730 282458009091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458009092 ATP binding site [chemical binding]; other site 282458009093 Mg2+ binding site [ion binding]; other site 282458009094 G-X-G motif; other site 282458009095 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 56.80, E-value 2.5e-14 282458009096 2 probable transmembrane helices predicted for SAR1975 by TMHMM2.0 at aa 13-35 and 45-67 282458009097 Predicted membrane protein [Function unknown]; Region: COG4758 282458009098 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 282458009099 4 probable transmembrane helices predicted for SAR1976 by TMHMM2.0 at aa 5-27, 31-49, 56-73 and 77-94 282458009100 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 282458009101 active site 282458009102 Pfam match to entry PF00557 Peptidase_M24, metallopeptidase M24, score 194.10, E-value 2.2e-54 282458009103 Signal peptide predicted for SAR1980 by SignalP 2.0 HMM (Signal peptide probabilty 0.754) with cleavage site probability 0.462 between residues 38 and 39; signal peptide 282458009104 Predicted membrane protein [Function unknown]; Region: COG4129 282458009105 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 282458009106 4 probable transmembrane helices predicted for SAR1980 by TMHMM2.0 at aa 18-40, 61-79, 89-111 and 123-145 282458009107 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 282458009108 catalytic triad [active] 282458009109 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 282458009110 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 282458009111 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 282458009112 Pfam match to entry PF01225 Mur_ligase, Mur ligase, catalytic domain, score 23.60, E-value 4.7e-06 282458009113 Pfam match to entry PF01225 Mur_ligase, Mur ligase, catalytic domain, score 21.50, E-value 1.9e-05 282458009114 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 282458009115 Ferritin-like domain; Region: Ferritin; pfam00210 282458009116 ferroxidase diiron center [ion binding]; other site 282458009117 Pfam match to entry PF00210 ferritin, Ferritin, score 118.00, E-value 3.7e-34 282458009118 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 282458009119 active site 282458009120 catalytic site [active] 282458009121 substrate binding site [chemical binding]; other site 282458009122 Pfam match to entry PF00929 Exonuclease, Exonuclease, score 100.90, E-value 2.5e-26 282458009123 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 282458009124 active site 282458009125 DNA polymerase IV; Validated; Region: PRK02406 282458009126 DNA binding site [nucleotide binding] 282458009127 Pfam match to entry PF00817 IMS, impB/mucB/samB family, score 382.70, E-value 3.7e-111 282458009128 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 282458009129 4 probable transmembrane helices predicted for SAR1987 by TMHMM2.0 at aa 15-37, 50-72, 104-126 and 131-153 282458009130 TRAM domain; Region: TRAM; cl01282 282458009131 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 282458009132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458009133 S-adenosylmethionine binding site [chemical binding]; other site 282458009134 PS01231 RNA methyltransferase trmA family signature 2. 282458009135 PS01230 RNA methyltransferase trmA family signature 1. 282458009136 putative lipid kinase; Reviewed; Region: PRK13337 282458009137 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 282458009138 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 282458009139 Pfam match to entry PF00781 DAGKc, Diacylglycerol kinase catalytic domain (presumed), score 88.30, E-value 1.6e-22 282458009140 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 282458009141 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 282458009142 GatB domain; Region: GatB_Yqey; pfam02637 282458009143 Pfam match to entry PF02637 DUF186, Uncharacterized protein, YqeY family COG1610, score 238.20, E-value 1.2e-67 282458009144 Pfam match to entry PF01162 GatB, PET112 family, score 140.90, E-value 2.3e-38 282458009145 Pfam match to entry PF02934 GatB_N, , score 528.10, E-value 7.3e-158 282458009146 PS01234 PET112 family signature. 282458009147 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 282458009148 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 282458009149 Pfam match to entry PF01425 Amidase, Amidase, score 684.70, E-value 4.5e-202 282458009150 PS00571 Amidases signature. 282458009151 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 282458009152 Pfam match to entry PF02686 Glu-tRNAGln, Glu-tRNAGln amidotransferase C subunit, score 80.20, E-value 4.3e-20 282458009153 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 282458009154 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 282458009155 Na binding site [ion binding]; other site 282458009156 13 probable transmembrane helices predicted for SAR1994 by TMHMM2.0 at aa 15-37, 49-71, 86-105, 137-159, 174-196, 203-225, 245-267, 288-310, 320-342, 382-400, 410-432, 439-458 and 468-487 282458009157 Pfam match to entry PF00474 SSF, Sodium:solute symporter family, score 397.70, E-value 1.2e-115 282458009158 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 282458009159 Signal peptide predicted for SAR1995 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.505 between residues 26 and 27; signal peptide 282458009160 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 282458009161 putative dimer interface [polypeptide binding]; other site 282458009162 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 282458009163 putative dimer interface [polypeptide binding]; other site 282458009164 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458009165 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 282458009166 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 282458009167 nucleotide binding pocket [chemical binding]; other site 282458009168 K-X-D-G motif; other site 282458009169 catalytic site [active] 282458009170 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 282458009171 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 282458009172 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 282458009173 Dimer interface [polypeptide binding]; other site 282458009174 Pfam match to entry PF00533 BRCT, BRCA1 C Terminus (BRCT) domain, score 67.00, E-value 3.5e-19 282458009175 PS01056 NAD-dependent DNA ligase signature 2. 282458009176 Pfam match to entry PF01653 DNA_ligase_N, NAD-dependent DNA ligase, score 632.40, E-value 2.4e-186 282458009177 PS01055 NAD-dependent DNA ligase signature 1. 282458009178 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 282458009179 Part of AAA domain; Region: AAA_19; pfam13245 282458009180 Family description; Region: UvrD_C_2; pfam13538 282458009181 Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase, score 839.20, E-value 1.4e-248 282458009182 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009183 PcrB family; Region: PcrB; pfam01884 282458009184 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 282458009185 substrate binding site [chemical binding]; other site 282458009186 putative active site [active] 282458009187 dimer interface [polypeptide binding]; other site 282458009188 Pfam match to entry PF01884 PcrB, PcrB family, score 499.40, E-value 2.7e-146 282458009189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 282458009190 Predicted helix-turn-helix motif with score 1037 (+2.72 SD) at aa 57-78, sequence YTYATIEQESGASTATISRVKR 282458009191 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 282458009192 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 282458009193 tetramer interface [polypeptide binding]; other site 282458009194 active site 282458009195 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 282458009196 Pfam match to entry PF00206 lyase_1, Lyase, score 395.30, E-value 6e-115 282458009197 PS00163 Fumarate lyases signature. 282458009198 Signal peptide predicted for SAR2001 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.811 between residues 25 and 26; signal peptide 282458009199 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 282458009200 Staphostatin A; Region: Staphostatin_A; pfam09022 282458009201 NETI protein; Region: NETI; pfam14044 282458009202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 282458009203 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 282458009204 3 probable transmembrane helices predicted for SAR2004 by TMHMM2.0 at aa 10-32, 39-61 and 66-83 282458009205 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 282458009206 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 282458009207 homodimer interface [polypeptide binding]; other site 282458009208 NAD binding pocket [chemical binding]; other site 282458009209 ATP binding pocket [chemical binding]; other site 282458009210 Mg binding site [ion binding]; other site 282458009211 active-site loop [active] 282458009212 Pfam match to entry PF02540 NAD_synthase, NAD synthase, score 186.80, E-value 3.5e-52 282458009213 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 282458009214 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 282458009215 active site 282458009216 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 282458009217 active site 282458009218 dimer interface [polypeptide binding]; other site 282458009219 Pfam match to entry PF02898 NO_synthase, Nitric oxide synthase, oxygenase domain, score 381.10, E-value 1.1e-110 282458009220 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 282458009221 Prephenate dehydratase; Region: PDT; pfam00800 282458009222 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 282458009223 putative L-Phe binding site [chemical binding]; other site 282458009224 Pfam match to entry PF00800 PDT, Prephenate dehydratase, score 99.70, E-value 5.6e-26 282458009225 Pfam match to entry PF01842 ACT, ACT domain, score 32.40, E-value 1e-05 282458009226 Signal peptide predicted for SAR2009 by SignalP 2.0 HMM (Signal peptide probabilty 0.845) with cleavage site probability 0.775 between residues 64 and 65; signal peptide 282458009227 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 282458009228 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 282458009229 transmembrane helices; other site 282458009230 Pfam match to entry PF00939 Na_sulph_symp, Sodium:sulfate symporter transmembrane region, score 253.20, E-value 3.5e-72 282458009231 14 probable transmembrane helices predicted for SAR2009 by TMHMM2.0 at aa 28-50, 57-74, 78-97, 110-127, 158-180, 205-227, 242-264, 299-318, 323-345, 365-387, 397-419, 426-448, 452-474 and 487-509 282458009232 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 282458009233 PS00435 Peroxidases proximal heme-ligand signature. 282458009234 Isochorismatase family; Region: Isochorismatase; pfam00857 282458009235 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 282458009236 catalytic triad [active] 282458009237 conserved cis-peptide bond; other site 282458009238 Pfam match to entry PF00857 Isochorismatase, Isochorismatase, score 26.20, E-value 8.7e-07 282458009239 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 282458009240 DHH family; Region: DHH; pfam01368 282458009241 DHHA2 domain; Region: DHHA2; pfam02833 282458009242 Pfam match to entry PF01368 DHH, DHH family, score -7.70, E-value 0.011 282458009243 Pfam match to entry PF02833 DHHA2, DHHA2 domain, score 144.20, E-value 2.2e-39 282458009244 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 282458009245 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 282458009246 NAD(P) binding site [chemical binding]; other site 282458009247 catalytic residues [active] 282458009248 Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase, score 504.90, E-value 6.1e-148 282458009249 PS00687 Aldehyde dehydrogenases glutamic acid active site. 282458009250 PS00070 Aldehyde dehydrogenases cysteine active site. 282458009251 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 282458009252 YolD-like protein; Region: YolD; pfam08863 282458009253 Signal peptide predicted for SAR2016 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.623 between residues 31 and 32; signal peptide 282458009254 1 probable transmembrane helix predicted for SAR2016 by TMHMM2.0 at aa 12-34 282458009255 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 282458009256 active site 282458009257 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 282458009258 Signal peptide predicted for SAR2018 by SignalP 2.0 HMM (Signal peptide probabilty 0.961) with cleavage site probability 0.426 between residues 18 and 19; signal peptide 282458009259 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 282458009260 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 282458009261 1 probable transmembrane helix predicted for SAR2018 by TMHMM2.0 at aa 4-26 282458009262 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 282458009263 3 probable transmembrane helices predicted for SAR2019 by TMHMM2.0 at aa 81-103, 107-129 and 136-158 282458009264 Bacterial PH domain; Region: DUF304; cl01348 282458009265 1 probable transmembrane helix predicted for SAR2020 by TMHMM2.0 at aa 21-40 282458009266 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 282458009267 Signal peptide predicted for SAR2022 by SignalP 2.0 HMM (Signal peptide probabilty 0.819) with cleavage site probability 0.502 between residues 41 and 42; signal peptide 282458009268 6 probable transmembrane helices predicted for SAR2022 by TMHMM2.0 at aa 21-38, 48-70, 102-124, 139-161, 166-188 and 219-241 282458009269 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 282458009270 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 282458009271 Walker A/P-loop; other site 282458009272 ATP binding site [chemical binding]; other site 282458009273 Q-loop/lid; other site 282458009274 ABC transporter signature motif; other site 282458009275 Walker B; other site 282458009276 D-loop; other site 282458009277 H-loop/switch region; other site 282458009278 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 148.10, E-value 1.5e-40 282458009279 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009280 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 282458009281 6 probable transmembrane helices predicted for SAR2024 by TMHMM2.0 at aa 13-32, 37-55, 87-109, 119-141, 153-175 and 188-210 282458009282 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 282458009283 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 282458009284 Walker A/P-loop; other site 282458009285 ATP binding site [chemical binding]; other site 282458009286 Q-loop/lid; other site 282458009287 ABC transporter signature motif; other site 282458009288 Walker B; other site 282458009289 D-loop; other site 282458009290 H-loop/switch region; other site 282458009291 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 143.00, E-value 5.2e-39 282458009292 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009293 Predicted transcriptional regulators [Transcription]; Region: COG1725 282458009294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 282458009295 DNA-binding site [nucleotide binding]; DNA binding site 282458009296 Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 60.20, E-value 4.8e-17 282458009297 Signal peptide predicted for SAR2027 by SignalP 2.0 HMM (Signal peptide probabilty 0.689) with cleavage site probability 0.400 between residues 28 and 29; signal peptide 282458009298 2 probable transmembrane helices predicted for SAR2027 by TMHMM2.0 at aa 7-24 and 34-51 282458009299 1 probable transmembrane helix predicted for SAR2027a by TMHMM2.0 at aa 5-24 282458009300 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 282458009301 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 282458009302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458009303 homodimer interface [polypeptide binding]; other site 282458009304 catalytic residue [active] 282458009305 Insertion sequence IS1272 282458009306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 282458009307 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458009308 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 282458009309 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458009310 Signal peptide predicted for SAR2030 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.935 between residues 30 and 31; signal peptide 282458009311 MAP domain; Region: MAP; pfam03642 282458009312 MAP domain; Region: MAP; pfam03642 282458009313 MAP domain; Region: MAP; pfam03642 282458009314 MAP domain; Region: MAP; pfam03642 282458009315 MAP domain; Region: MAP; pfam03642 282458009316 MAP domain; Region: MAP; pfam03642 282458009317 Highly similar to Staphylococcus aureus phospholipase C precursor Hlb or Plc SWALL:PHLC_STAAU (SWALL:P09978) (330 aa) fasta scores: E(): 1.8e-121, 98.48% id in 330 aa. CDS is disrupted by the integration of the prophage phiSa3(252) after residue 61;phospholipase C precursor (pseudogene) 282458009318 Signal peptide predicted for SAR2031 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.987 between residues 34 and 35 282458009319 Prophage 282458009320 Signal peptide predicted for SAR2032 by SignalP 2.0 HMM (Signal peptide probabilty 0.964) with cleavage site probability 0.798 between residues 52 and 53; signal peptide 282458009321 1 probable transmembrane helix predicted for SAR2032 by TMHMM2.0 at aa 29-51 282458009322 3 probable transmembrane helices predicted for SAR2033 by TMHMM2.0 at aa 7-29, 33-55 and 62-84 282458009323 3 probable transmembrane helices predicted for SAR2034 by TMHMM2.0 at aa 3-25, 35-57 and 62-84 282458009324 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 282458009325 Signal peptide predicted for SAR2035 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.656 between residues 31 and 32; signal peptide 282458009326 chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032 282458009327 Signal peptide predicted for SAR2036 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.640 between residues 28 and 29; signal peptide 282458009328 Gene remnant. Similar to the C-terminal regions of bacteriophage phi PVL amidase TR:O80064 (EMBL:AB009866) (484 aa) fasta scores: E(): 4.8e-40, 87.2% id in 125 aa, and to Staphylococcus aureus temperate phage phiSLT amidase TR:Q9B0C3 (EMBL:AB045978) (484 aa) fasta scores: E(): 6.6e-39, 84.8% id in 125 aa. Similar to the C-terminal region of SAR1497, 93.878% identity (93.878% ungapped) in 98 aa overlap;amidase (fragment) 282458009329 Signal peptide predicted for SAR2039 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.983 between residues 27 and 28; signal peptide 282458009330 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 282458009331 Pfam match to entry PF02821 Staphylokinase, Staphylokinase/Streptokinase, score 138.10, E-value 1.6e-37 282458009332 1 probable transmembrane helix predicted for SAR2039 by TMHMM2.0 at aa 5-27 282458009333 CHAP domain; Region: CHAP; pfam05257 282458009334 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009335 Small integral membrane protein [Function unknown]; Region: COG5546 282458009336 Signal peptide predicted for SAR2041 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.986 between residues 31 and 32; signal peptide 282458009337 1 probable transmembrane helix predicted for SAR2041 by TMHMM2.0 at aa 12-34 282458009338 1 probable transmembrane helix predicted for SAR2042 by TMHMM2.0 at aa 30-52 282458009339 Signal peptide predicted for SAR2043 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.477 between residues 24 and 25; signal peptide 282458009340 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 282458009341 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282458009342 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 247.70, E-value 1.6e-70 282458009343 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282458009344 PS00277 Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin signature 1. 282458009345 Pfam match to entry PF01123 Stap_Strp_toxin, Staphylococcal/Streptococcal toxin, OB-fold domain, score 203.00, E-value 4.7e-57 282458009346 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 282458009347 Ligand-gated ion channel; Region: Lig_chan; pfam00060 282458009348 1 probable transmembrane helix predicted for SAR2045 by TMHMM2.0 at aa 98-120 282458009349 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 282458009350 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 282458009351 Phage tail protein; Region: Sipho_tail; cl17486 282458009352 Phage tail protein; Region: Sipho_tail; cl17486 282458009353 Phage-related minor tail protein [Function unknown]; Region: COG5280 282458009354 Phage-related protein [Function unknown]; Region: COG5412 282458009355 Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606 282458009356 Peptidase family M23; Region: Peptidase_M23; pfam01551 282458009357 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 282458009358 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 282458009359 N-acetyl-D-glucosamine binding site [chemical binding]; other site 282458009360 catalytic residue [active] 282458009361 Pfam match to entry PF01464 SLT, Transglycosylase SLT domain, score 15.80, E-value 0.0039 282458009362 Pfam match to entry PF01551 Peptidase_M37, Peptidase M23/M37, score 83.70, E-value 3.7e-21 282458009363 6 probable transmembrane helices predicted for SAR2050 by TMHMM2.0 at aa 487-509, 516-538, 548-570, 657-679, 694-716 and 735-757 282458009364 Predicted helix-turn-helix motif for SAR2050 with score 973.000, SD 2.50 at aa 407-428, sequence FSYQEFLKTIEDSQGTVNQTFK 282458009365 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009366 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 282458009367 Pfam match to entry PF02368 Big_2, Bacterial Ig-like domain (group 2), score 49.50, E-value 7.5e-11 282458009368 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 282458009369 Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf123 TR:Q9B0D7 (EMBL:AB045978) (123 aa) fasta scores: E(): 3.7e-08, 31.7% id in 123 aa. Contains a frameshift after codon 44. Frameshift occurs at a poly A hexamer;hypothetical phage protein (pseudogene) 282458009370 Translocation protein Sec62; Region: Sec62; cl02170 282458009371 Phage capsid family; Region: Phage_capsid; pfam05065 282458009372 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 282458009373 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 282458009374 oligomer interface [polypeptide binding]; other site 282458009375 active site residues [active] 282458009376 Pfam match to entry PF00574 CLP_protease, Clp protease, score 28.80, E-value 9.9e-10 282458009377 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 282458009378 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 282458009379 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 282458009380 HNH endonuclease; Region: HNH; pfam01844 282458009381 active site 282458009382 PS00190 Cytochrome c family heme-binding site signature. 282458009383 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 282458009384 Signal peptide predicted for SAR2068 by SignalP 2.0 HMM (Signal peptide probabilty 0.931) with cleavage site probability 0.351 between residues 25 and 26; signal peptide 282458009385 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 282458009386 1 probable transmembrane helix predicted for SAR2068 by TMHMM2.0 at aa 4-22 282458009387 Transcriptional activator RinB; Region: RinB; pfam06116 282458009388 Signal peptide predicted for SAR2070 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.503 between residues 41 and 42; signal peptide 282458009389 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 282458009390 1 probable transmembrane helix predicted for SAR2070 by TMHMM2.0 at aa 13-35 282458009391 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 282458009392 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 282458009393 trimer interface [polypeptide binding]; other site 282458009394 active site 282458009395 Pfam match to entry PF00692 dUTPase, dUTPase, score 78.50, E-value 1.4e-19 282458009396 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 282458009397 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 282458009398 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 282458009399 Similar to bacteriophage phi PVL hypothetical protein Orf 48 TR:O80087 (EMBL:AB009866) (134 aa) fasta scores: E(): 1.3e-21, 69.4% id in 134 aa. CDS is contains an internal deletion of 31 amino acids relative to the bacteriophage phi PVL protein. The deletion has resulted in a frameshift after codon 66;hypothetical phage protein (pseudogene) 282458009400 Similar to bacteriophage phi PVL hypothetical protein Orf 46 TR:O80085 (EMBL:AB009866) (297 aa) fasta scores: E(): 2.9e-63, 64.31% id in 297 aa, and to bacteriophage A118 hypothetical protein gp49 TR:Q9T171 (EMBL:AJ242593) (310 aa) fasta scores: E(): 3.9e-13, 28.84% id in 312 aa. Contains a frameshift after codon 116. Frameshift occurs at the start of an imperfect repeat (caacaaatcaa x5); phage regulatory protein (pseudogene) 282458009401 Predicted helix-turn-helix motif with score 1209 (+3.30 SD) at aa 58-79, sequence FGRKRASEELRLKESTVRDYIK 282458009402 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 282458009403 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 282458009404 dimer interface [polypeptide binding]; other site 282458009405 ssDNA binding site [nucleotide binding]; other site 282458009406 tetramer (dimer of dimers) interface [polypeptide binding]; other site 282458009407 Pfam match to entry PF00436 SSB, Single-strand binding protein family, score 195.80, E-value 2.3e-57 282458009408 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 282458009409 RecT family; Region: RecT; pfam03837 282458009410 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 282458009411 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009412 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 282458009413 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 282458009414 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 282458009415 Signal peptide predicted for SAR2091 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.682 between residues 38 and 39; signal peptide 282458009416 1 probable transmembrane helix predicted for SAR2091 by TMHMM2.0 at aa 7-29 282458009417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 282458009418 Phage anti-repressor protein [Transcription]; Region: COG3561 282458009419 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 282458009420 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 282458009421 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 282458009422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282458009423 non-specific DNA binding site [nucleotide binding]; other site 282458009424 salt bridge; other site 282458009425 sequence-specific DNA binding site [nucleotide binding]; other site 282458009426 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 43.80, E-value 3.8e-09 282458009427 Predicted helix-turn-helix motif with score 1869 (+5.55 SD) at aa 13-34, sequence LTQKELGDLFKVSSRTIQNMEK 282458009428 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282458009429 non-specific DNA binding site [nucleotide binding]; other site 282458009430 salt bridge; other site 282458009431 sequence-specific DNA binding site [nucleotide binding]; other site 282458009432 Predicted transcriptional regulator [Transcription]; Region: COG2932 282458009433 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 282458009434 Catalytic site [active] 282458009435 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 46.30, E-value 6.8e-10 282458009436 Predicted helix-turn-helix motif with score 2092 (+6.31 SD) at aa 22-43, sequence MSQKKLAELINIKPSTLSDYLN 282458009437 Pfam match to entry PF00717 Peptidase_S24, Peptidase S24, score 14.90, E-value 6.2e-05 282458009438 Pfam match to entry PF00461 Peptidase_S26, Signal peptidase I, score 13.00, E-value 0.0055 282458009439 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 282458009440 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 282458009441 active site 282458009442 catalytic site [active] 282458009443 substrate binding site [chemical binding]; other site 282458009444 Pfam match to entry PF00929 Exonuclease, Exonuclease, score 35.40, E-value 1.3e-06 282458009445 Pfam match to entry PF00533 BRCT, BRCA1 C Terminus (BRCT) domain, score 18.10, E-value 0.00031 282458009446 Signal peptide predicted for SAR2104 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.580 between residues 24 and 25; signal peptide 282458009447 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458009448 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 282458009449 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 282458009450 Int/Topo IB signature motif; other site 282458009451 Pfam match to entry PF00589 Phage_integrase, Phage integrase, score 63.30, E-value 5.1e-15 282458009452 Signal peptide predicted for SAR2107 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.983 between residues 29 and 30; signal peptide 282458009453 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 282458009454 Pfam match to entry PF01117 Aerolysin, Aerolysin/Leukocidin family toxin, score -61.80, E-value 0.00022 282458009455 Signal peptide predicted for SAR2108 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.390 between residues 27 and 28; signal peptide 282458009456 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 282458009457 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 282458009458 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 282458009459 metal binding site [ion binding]; metal-binding site 282458009460 dimer interface [polypeptide binding]; other site 282458009461 Pfam match to entry PF01546 Peptidase_M20, Peptidase M20/M25/M40, score 230.80, E-value 1.9e-65 282458009462 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 282458009463 Signal peptide predicted for SAR2111 by SignalP 2.0 HMM (Signal peptide probabilty 0.917) with cleavage site probability 0.389 between residues 33 and 34; signal peptide 282458009464 Cation transport protein; Region: TrkH; cl17365 282458009465 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 282458009466 Pfam match to entry PF02386 TrkH, Sodium transport protein, score 342.00, E-value 6.5e-99 282458009467 11 probable transmembrane helices predicted for SAR2111 by TMHMM2.0 at aa 7-29, 71-93, 123-145, 155-177, 184-206, 221-240, 270-292, 297-319, 339-361, 365-384 and 397-419 282458009468 Poor database matches. Similar to the N-terminal region of Bacillus thuringiensis transposase for insertion sequence element IS232 SW:T232_BACTB (Q99335) (431 aa) fasta scores: E(): 1.3e-06, 51.78% id in 56 aa. Probable gene remnant; transposase (fragment) 282458009469 Predicted helix-turn-helix motif with score 1406 (+3.98 SD) at aa 33-54, sequence ISKSEIARHMGVDRRAVDKYSN 282458009470 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 282458009471 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 282458009472 ring oligomerisation interface [polypeptide binding]; other site 282458009473 ATP/Mg binding site [chemical binding]; other site 282458009474 stacking interactions; other site 282458009475 hinge regions; other site 282458009476 Pfam match to entry PF00118 cpn60_TCP1, TCP-1/cpn60 chaperonin family, score 882.50, E-value 1.3e-261 282458009477 PS00296 Chaperonins cpn60 signature. 282458009478 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 282458009479 oligomerisation interface [polypeptide binding]; other site 282458009480 mobile loop; other site 282458009481 roof hairpin; other site 282458009482 Pfam match to entry PF00166 cpn10, Chaperonin 10 Kd subunit, score 190.30, E-value 3.1e-53 282458009483 PS00681 Chaperonins cpn10 signature. 282458009484 CAAX protease self-immunity; Region: Abi; pfam02517 282458009485 6 probable transmembrane helices predicted for SAR2118 by TMHMM2.0 at aa 5-25, 40-62, 82-104, 119-141, 162-180 and 185-202 282458009486 Pfam match to entry PF02517 Abi, CAAX amino terminal protease, score 86.80, E-value 4.3e-22 282458009487 Signal peptide predicted for SAR2119 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.973 between residues 33 and 34; signal peptide 282458009488 1 probable transmembrane helix predicted for SAR2119 by TMHMM2.0 at aa 371-390 282458009489 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 282458009490 dimer interface [polypeptide binding]; other site 282458009491 FMN binding site [chemical binding]; other site 282458009492 Predicted amidohydrolase [General function prediction only]; Region: COG0388 282458009493 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 282458009494 putative active site [active] 282458009495 catalytic triad [active] 282458009496 putative dimer interface [polypeptide binding]; other site 282458009497 Pfam match to entry PF00795 CN_hydrolase, Carbon-nitrogen hydrolase, score 153.60, E-value 3.3e-42 282458009498 PS01227 Uncharacterized protein family UPF0012 signature. 282458009499 delta-hemolysin; Provisional; Region: PRK14752 282458009500 Accessory gene regulator B; Region: AgrB; smart00793 282458009501 5 probable transmembrane helices predicted for SAR2123 by TMHMM2.0 at aa 47-69, 82-104, 108-125, 142-159 and 164-183 282458009502 Staphylococcal AgrD protein; Region: AgrD; smart00794 282458009503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458009504 Mg2+ binding site [ion binding]; other site 282458009505 G-X-G motif; other site 282458009506 6 probable transmembrane helices predicted for SAR2125 by TMHMM2.0 at aa 7-29, 54-71, 78-100, 110-132, 145-167 and 182-204 282458009507 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 9.20, E-value 0.37 282458009508 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 282458009509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458009510 active site 282458009511 phosphorylation site [posttranslational modification] 282458009512 intermolecular recognition site; other site 282458009513 dimerization interface [polypeptide binding]; other site 282458009514 LytTr DNA-binding domain; Region: LytTR; pfam04397 282458009515 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 103.40, E-value 4.5e-27 282458009516 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 282458009517 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 282458009518 putative substrate binding site [chemical binding]; other site 282458009519 putative ATP binding site [chemical binding]; other site 282458009520 Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 354.60, E-value 1.1e-102 282458009521 PS00584 pfkB family of carbohydrate kinases signature 2. 282458009522 PS00583 pfkB family of carbohydrate kinases signature 1. 282458009523 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 282458009524 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 282458009525 substrate binding [chemical binding]; other site 282458009526 active site 282458009527 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 282458009528 Pfam match to entry PF00251 Glyco_hydro_32, Glycosyl hydrolases family 32, score 641.70, E-value 4.1e-189 282458009529 PS00609 Glycosyl hydrolases family 32 active site. 282458009530 Transcriptional regulators [Transcription]; Region: PurR; COG1609 282458009531 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 282458009532 DNA binding site [nucleotide binding] 282458009533 domain linker motif; other site 282458009534 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 282458009535 dimerization interface [polypeptide binding]; other site 282458009536 ligand binding site [chemical binding]; other site 282458009537 Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family., score -24.90, E-value 0.0088 282458009538 Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, score 39.20, E-value 1.3e-09 282458009539 Predicted helix-turn-helix motif with score 2286 (+6.97 SD) at aa 2-23, sequence KNISDIAKLAGVSKSTVSRFLN 282458009540 PS00356 Bacterial regulatory proteins, lacI family signature. 282458009541 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 282458009542 Signal peptide predicted for SAR2130 by SignalP 2.0 HMM (Signal peptide probabilty 0.856) with cleavage site probability 0.505 between residues 33 and 34; signal peptide 282458009543 Pfam match to entry PF00909 Ammonium_transp, Ammonium Transporter Family, score 489.20, E-value 3.3e-143 282458009544 11 probable transmembrane helices predicted for SAR2130 by TMHMM2.0 at aa 6-28, 41-63, 95-117, 124-146, 156-178, 190-212, 222-244, 253-272, 276-298, 310-329 and 349-371 282458009545 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 282458009546 CPxP motif; other site 282458009547 Pfam match to entry PF01206 UPF0033, Uncharacterized protein family UPF0033, score 93.50, E-value 4.1e-24 282458009548 Predicted transporter component [General function prediction only]; Region: COG2391 282458009549 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 282458009550 Sulphur transport; Region: Sulf_transp; pfam04143 282458009551 9 probable transmembrane helices predicted for SAR2132 by TMHMM2.0 at aa 4-21, 41-63, 73-92, 105-127, 147-169, 199-218, 248-267, 288-310 and 320-339 282458009552 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 282458009553 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 282458009554 CoA binding domain; Region: CoA_binding; pfam02629 282458009555 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 282458009556 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282458009557 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282458009558 ABC transporter; Region: ABC_tran_2; pfam12848 282458009559 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282458009560 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 159.90, E-value 4.4e-44 282458009561 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009562 PS00211 ABC transporters family signature. 282458009563 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 147.30, E-value 2.7e-40 282458009564 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009565 PS00211 ABC transporters family signature. 282458009566 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 282458009567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282458009568 Walker A/P-loop; other site 282458009569 ATP binding site [chemical binding]; other site 282458009570 Q-loop/lid; other site 282458009571 ABC transporter signature motif; other site 282458009572 Walker B; other site 282458009573 D-loop; other site 282458009574 H-loop/switch region; other site 282458009575 2 probable transmembrane helices predicted for SAR2135 by TMHMM2.0 at aa 5-27 and 159-181 282458009576 Pfam match to entry PF02866 ldh_C, lactate/malate dehydrogenase, alpha/beta C-terminal domain, score 10.50, E-value 0.13 282458009577 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009578 UGMP family protein; Validated; Region: PRK09604 282458009579 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 282458009580 Pfam match to entry PF00814 Peptidase_M22, Glycoprotease, score 521.10, E-value 8.1e-153 282458009581 PS01016 Glycoprotease signature. 282458009582 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 282458009583 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458009584 Coenzyme A binding pocket [chemical binding]; other site 282458009585 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 69.70, E-value 6e-17 282458009586 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 282458009587 Glycoprotease family; Region: Peptidase_M22; pfam00814 282458009588 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 282458009589 Pfam match to entry PF02367 UPF0079, Uncharacterised P-loop hydrolase UPF0079, score 146.40, E-value 4.9e-40 282458009590 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009591 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 282458009592 6-phosphogluconate dehydratase; Region: edd; TIGR01196 282458009593 Pfam match to entry PF00920 ILVD_EDD, Dehydratase, score 856.20, E-value 1.1e-253 282458009594 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 282458009595 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 282458009596 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 282458009597 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 282458009598 PYR/PP interface [polypeptide binding]; other site 282458009599 dimer interface [polypeptide binding]; other site 282458009600 TPP binding site [chemical binding]; other site 282458009601 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 282458009602 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 282458009603 TPP-binding site [chemical binding]; other site 282458009604 dimer interface [polypeptide binding]; other site 282458009605 Pfam match to entry PF02776 TPP_enzymes_N, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 304.50, E-value 1.3e-87 282458009606 Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzyme, central domain, score 183.80, E-value 2.7e-51 282458009607 Pfam match to entry PF02775 TPP_enzymes_C, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 301.90, E-value 8e-87 282458009608 PS00187 Thiamine pyrophosphate enzymes signature. 282458009609 Similar to the N-terminal regions of Escherichia coli acetolactate synthase isozyme III small subunit IlvH SW:ILVH_ECOLI (P00894) (163 aa) fasta scores: E(): 0.004, 32.43% id in 74 aa, and Bacillus subtilis acetolactate synthase small subunit IlvH SW:ILVH_BACSU (P37252) (174 aa) fasta scores: E(): 4.4e-06, 37.83% id in 74 aa. Probable gene remnant;acetolactate synthase isozyme III small subunit (fragment) 282458009610 Pfam match to entry PF01842 ACT, ACT domain, score 34.70, E-value 2.1e-06 282458009611 ketol-acid reductoisomerase; Provisional; Region: PRK05479 282458009612 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 282458009613 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 282458009614 Pfam match to entry PF01450 IlvC, Acetohydroxy acid isomeroreductase, catalytic domain, score 288.20, E-value 1.1e-82 282458009615 2-isopropylmalate synthase; Validated; Region: PRK00915 282458009616 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 282458009617 active site 282458009618 catalytic residues [active] 282458009619 metal binding site [ion binding]; metal-binding site 282458009620 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 282458009621 Pfam match to entry PF00682 HMGL-like, HMGL-like, score 393.10, E-value 2.7e-114 282458009622 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 282458009623 tartrate dehydrogenase; Region: TTC; TIGR02089 282458009624 Pfam match to entry PF00180 isodh, Isocitrate and isopropylmalate dehydrogenases, score 582.50, E-value 1.6e-173 282458009625 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 282458009626 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 282458009627 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 282458009628 substrate binding site [chemical binding]; other site 282458009629 ligand binding site [chemical binding]; other site 282458009630 Pfam match to entry PF00330 aconitase, Aconitase (aconitate hydratase), score 738.20, E-value 5e-225 282458009631 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009632 PS00450 Aconitase signature 1. 282458009633 PS01244 Aconitase signature 2. 282458009634 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 282458009635 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 282458009636 substrate binding site [chemical binding]; other site 282458009637 Pfam match to entry PF00694 Aconitase_C, Aconitase C-terminal domain, score 196.20, E-value 5.3e-55 282458009638 threonine dehydratase; Validated; Region: PRK08639 282458009639 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 282458009640 tetramer interface [polypeptide binding]; other site 282458009641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458009642 catalytic residue [active] 282458009643 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 282458009644 putative Ile/Val binding site [chemical binding]; other site 282458009645 Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme, score 296.10, E-value 4.2e-85 282458009646 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 282458009647 Pfam match to entry PF00585 Thr_dehydrat_C, C-terminal domain of Threonine dehydratase, score 88.10, E-value 1.8e-22 282458009648 Signal peptide predicted for SAR2149 by SignalP 2.0 HMM (Signal peptide probabilty 0.975) with cleavage site probability 0.339 between residues 35 and 36; signal peptide 282458009649 1 probable transmembrane helix predicted for SAR2149 by TMHMM2.0 at aa 3-25 282458009650 hypothetical protein; Provisional; Region: PRK04351 282458009651 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 282458009652 Pfam match to entry PF01020 Ribosomal_L40e, Ribosomal L40e family, score 9.40, E-value 2.4 282458009653 PS00190 Cytochrome c family heme-binding site signature. 282458009654 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 282458009655 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 282458009656 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 282458009657 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 282458009658 RNA binding site [nucleotide binding]; other site 282458009659 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 66.10, E-value 1.1e-16 282458009660 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 282458009661 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 282458009662 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 282458009663 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 282458009664 DNA binding residues [nucleotide binding] 282458009665 Pfam match to entry PF00140 sigma70, Sigma-70 factor, score 244.40, E-value 1.6e-69 282458009666 Predicted helix-turn-helix motif with score 1939 (+5.79 SD) at aa 223-244, sequence LSQKETGERIGLSQMHVSRLQR 282458009667 PS00715 Sigma-70 factors family signature 1. 282458009668 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 282458009669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458009670 ATP binding site [chemical binding]; other site 282458009671 Mg2+ binding site [ion binding]; other site 282458009672 G-X-G motif; other site 282458009673 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 14.60, E-value 0.012 282458009674 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 282458009675 anti sigma factor interaction site; other site 282458009676 regulatory phosphorylation site [posttranslational modification]; other site 282458009677 Pfam match to entry PF01740 STAS, STAS domain, score 90.90, E-value 2.6e-23 282458009678 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 282458009679 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 282458009680 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 282458009681 PemK-like protein; Region: PemK; pfam02452 282458009682 Pfam match to entry PF02452 PemK, PemK-like protein, score 200.80, E-value 2.1e-56 282458009683 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 282458009684 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 282458009685 active site 282458009686 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 282458009687 dimer interface [polypeptide binding]; other site 282458009688 substrate binding site [chemical binding]; other site 282458009689 catalytic residues [active] 282458009690 Pfam match to entry PF00842 Ala_racemase, Alanine racemase, score 421.40, E-value 8e-123 282458009691 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 282458009692 Pfam match to entry PF01648 ACPS, 4'-phosphopantetheinyl transferase superfamily, score 137.70, E-value 2.1e-37 282458009693 Uncharacterized conserved protein [Function unknown]; Region: COG3402 282458009694 2 probable transmembrane helices predicted for SAR2160 by TMHMM2.0 at aa 20-42 and 47-69 282458009695 Predicted membrane protein [Function unknown]; Region: COG3428 282458009696 Bacterial PH domain; Region: DUF304; pfam03703 282458009697 Bacterial PH domain; Region: DUF304; pfam03703 282458009698 6 probable transmembrane helices predicted for SAR2161 by TMHMM2.0 at aa 13-35, 45-67, 210-232, 252-274, 389-411 and 415-437 282458009699 Bacterial PH domain; Region: DUF304; cl01348 282458009700 2 probable transmembrane helices predicted for SAR2162 by TMHMM2.0 at aa 16-38 and 48-70 282458009701 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 282458009702 Signal peptide predicted for SAR2163 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.418 between residues 35 and 36; signal peptide 282458009703 Pfam match to entry PF02669 KdpC, K+-transporting ATPase, c chain, score 182.50, E-value 6.9e-51 282458009704 1 probable transmembrane helix predicted for SAR2163 by TMHMM2.0 at aa 7-29 282458009705 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 282458009706 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 282458009707 Soluble P-type ATPase [General function prediction only]; Region: COG4087 282458009708 7 probable transmembrane helices predicted for SAR2164 by TMHMM2.0 at aa 33-55, 59-81, 217-239, 249-271, 569-591, 611-630 and 650-672 282458009709 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 100.20, E-value 4.1e-26 282458009710 PS00154 E1-E2 ATPases phosphorylation site. 282458009711 Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 ATPase, score 175.10, E-value 3.9e-52 282458009712 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 282458009713 12 probable transmembrane helices predicted for SAR2165 by TMHMM2.0 at aa 4-26, 63-85, 127-149, 169-191, 245-267, 280-302, 325-347, 354-372, 376-398, 415-437, 484-506 and 526-548 282458009714 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 282458009715 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 282458009716 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 282458009717 Ligand Binding Site [chemical binding]; other site 282458009718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282458009719 dimer interface [polypeptide binding]; other site 282458009720 phosphorylation site [posttranslational modification] 282458009721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458009722 ATP binding site [chemical binding]; other site 282458009723 Mg2+ binding site [ion binding]; other site 282458009724 G-X-G motif; other site 282458009725 Pfam match to entry PF02702 KdpD, Osmosensitive K+ channel His kinase sensor domain, score 192.10, E-value 8.7e-54 282458009726 4 probable transmembrane helices predicted for SAR2166 by TMHMM2.0 at aa 383-405, 412-430, 434-453 and 466-484 282458009727 Pfam match to entry PF00512 signal, His Kinase A (phosphoacceptor) domain, score 48.60, E-value 1.3e-10 282458009728 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 97.90, E-value 1e-25 282458009729 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282458009730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458009731 active site 282458009732 phosphorylation site [posttranslational modification] 282458009733 intermolecular recognition site; other site 282458009734 dimerization interface [polypeptide binding]; other site 282458009735 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282458009736 DNA binding site [nucleotide binding] 282458009737 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 100.10, E-value 4.4e-26 282458009738 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 60.30, E-value 1.1e-16 282458009739 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 282458009740 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 282458009741 ATP binding site [chemical binding]; other site 282458009742 Mg++ binding site [ion binding]; other site 282458009743 motif III; other site 282458009744 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282458009745 nucleotide binding region [chemical binding]; other site 282458009746 ATP-binding site [chemical binding]; other site 282458009747 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 130.90, E-value 2.4e-35 282458009748 Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase, score 219.00, E-value 2.5e-68 282458009749 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 282458009750 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009751 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 282458009752 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 282458009753 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 282458009754 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 282458009755 Pfam match to entry PF02875 Mur_ligase_C, Mur ligase, glutamate ligase domain, score 58.60, E-value 1.3e-13 282458009756 Pfam match to entry PF01225 Mur_ligase, Mur ligase, catalytic domain, score 153.90, E-value 1.5e-44 282458009757 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 282458009758 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 282458009759 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 282458009760 Pfam match to entry PF01820 Dala_Dala_ligas, D-ala D-ala ligase, score 517.50, E-value 9.9e-152 282458009761 PS00843 D-alanine--D-alanine ligase signature 1. 282458009762 Signal peptide predicted for SAR2171 by SignalP 2.0 HMM (Signal peptide probabilty 0.808) with cleavage site probability 0.330 between residues 43 and 44; signal peptide 282458009763 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 282458009764 Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein, score 361.40, E-value 9.5e-105 282458009765 10 probable transmembrane helices predicted for SAR2171 by TMHMM2.0 at aa 19-41, 51-70, 77-96, 111-133, 153-172, 176-195, 202-224, 296-318, 330-352 and 362-384 282458009766 Insertion sequence IS1272 282458009767 Similar to C-terminal regions of Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 7.1e-58, 81.395% id in 258 aa, and Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 1e-29, 48.729% id in 236 aa. CDS contains multiple frameshift mutations, probable gene remnant; transposase (fragment) 282458009768 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 282458009769 Similar to Bacillus subtilis hypothetical protein YvgZ TR:O32222 (EMBL:Z99121) (101 aa) fasta scores: E(): 1.8e-11, 44.94% id in 89 aa, and to Bacillus halodurans hypothetical protein BH0558 TR:Q9KFC6 (EMBL:AP001508) (100 aa) fasta scores: E(): 4.5e-11, 42.7% id in 96 aa. Contains a frameshift after codon 47;conserved hypothetical protein (pseudogene) 282458009770 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 282458009771 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 282458009772 putative active site [active] 282458009773 catalytic site [active] 282458009774 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 282458009775 putative active site [active] 282458009776 catalytic site [active] 282458009777 2 probable transmembrane helices predicted for SAR2177 by TMHMM2.0 at aa 13-35 and 45-67 282458009778 Pfam match to entry PF00614 PLDc, Phospholipase D. Active site motif, score 39.70, E-value 6.6e-08 282458009779 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009780 PS00136 Serine proteases, subtilase, aspartic acid active site. 282458009781 Pfam match to entry PF00614 PLDc, Phospholipase D. Active site motif, score 39.30, E-value 8.6e-08 282458009782 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 282458009783 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 282458009784 Zn2+ binding site [ion binding]; other site 282458009785 Mg2+ binding site [ion binding]; other site 282458009786 Pfam match to entry PF01966 HD, HD domain, score 27.60, E-value 0.0003 282458009787 Signal peptide predicted for SAR2179 by SignalP 2.0 HMM (Signal peptide probabilty 0.973) with cleavage site probability 0.633 between residues 23 and 24; signal peptide 282458009788 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 282458009789 Pfam match to entry PF02096 60KD_IMP, 60Kd inner membrane protein, score 171.10, E-value 1.8e-47 282458009790 6 probable transmembrane helices predicted for SAR2179 by TMHMM2.0 at aa 5-22, 57-79, 131-153, 173-195, 207-224 and 229-251 282458009791 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 282458009792 thiamine phosphate binding site [chemical binding]; other site 282458009793 active site 282458009794 pyrophosphate binding site [ion binding]; other site 282458009795 Pfam match to entry PF02581 TMP-TENI, Thiamine monophosphate synthase/TENI, score 246.10, E-value 4.9e-70 282458009796 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 282458009797 substrate binding site [chemical binding]; other site 282458009798 multimerization interface [polypeptide binding]; other site 282458009799 ATP binding site [chemical binding]; other site 282458009800 Pfam match to entry PF02110 HK, Hydroxyethylthiazole kinase, score 303.20, E-value 3.1e-87 282458009801 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 282458009802 dimer interface [polypeptide binding]; other site 282458009803 substrate binding site [chemical binding]; other site 282458009804 ATP binding site [chemical binding]; other site 282458009805 thiaminase II; Region: salvage_TenA; TIGR04306 282458009806 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 282458009807 Signal peptide predicted for SAR2184 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.763 between residues 27 and 28; signal peptide 282458009808 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 282458009809 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 282458009810 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 282458009811 dimer interface [polypeptide binding]; other site 282458009812 ssDNA binding site [nucleotide binding]; other site 282458009813 tetramer (dimer of dimers) interface [polypeptide binding]; other site 282458009814 Pfam match to entry PF00436 SSB, Single-strand binding protein family, score 110.30, E-value 9.9e-32 282458009815 PS00735 Single-strand binding protein family signature 1. 282458009816 YwpF-like protein; Region: YwpF; pfam14183 282458009817 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 282458009818 Pfam match to entry PF01377 Thioester_dehyd, Thioester dehydrase, score 223.10, E-value 4e-63 282458009819 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 282458009820 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 282458009821 hinge; other site 282458009822 active site 282458009823 Pfam match to entry PF00275 EPSP_syntase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase), score 497.90, E-value 7.7e-146 282458009824 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009825 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009826 Predicted membrane protein [Function unknown]; Region: COG4836 282458009827 2 probable transmembrane helices predicted for SAR2189 by TMHMM2.0 at aa 7-26 and 41-63 282458009828 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 282458009829 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 282458009830 gamma subunit interface [polypeptide binding]; other site 282458009831 epsilon subunit interface [polypeptide binding]; other site 282458009832 LBP interface [polypeptide binding]; other site 282458009833 Pfam match to entry PF00401 ATP-synt_DE, ATP synthase, Delta/Epsilon chain, long alpha-helix domain, score 27.90, E-value 0.00024 282458009834 Pfam match to entry PF02823 ATP-synt_DE_N, ATP synthase, Delta/Epsilon chain, beta-sandwich domain, score 106.80, E-value 4.2e-28 282458009835 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 282458009836 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 282458009837 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 282458009838 alpha subunit interaction interface [polypeptide binding]; other site 282458009839 Walker A motif; other site 282458009840 ATP binding site [chemical binding]; other site 282458009841 Walker B motif; other site 282458009842 inhibitor binding site; inhibition site 282458009843 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 282458009844 Pfam match to entry PF00306 ATP-synt_ab_C, ATP synthase alpha/beta chain, C terminal domain, score 181.00, E-value 1.9e-50 282458009845 Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain, score 487.20, E-value 1.3e-142 282458009846 PS00152 ATP synthase alpha and beta subunits signature. 282458009847 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009848 Pfam match to entry PF02874 ATP-synt_ab_N, ATP synthase alpha/beta family, beta-barrel domain, score 93.90, E-value 3.2e-24 282458009849 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 282458009850 core domain interface [polypeptide binding]; other site 282458009851 delta subunit interface [polypeptide binding]; other site 282458009852 epsilon subunit interface [polypeptide binding]; other site 282458009853 Pfam match to entry PF00231 ATP-synt, ATP synthase, score 419.30, E-value 3.6e-122 282458009854 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 282458009855 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 282458009856 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 282458009857 beta subunit interaction interface [polypeptide binding]; other site 282458009858 Walker A motif; other site 282458009859 ATP binding site [chemical binding]; other site 282458009860 Walker B motif; other site 282458009861 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 282458009862 Pfam match to entry PF00306 ATP-synt_ab_C, ATP synthase alpha/beta chain, C terminal domain, score 119.60, E-value 5.9e-32 282458009863 Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain, score 538.00, E-value 6.3e-158 282458009864 PS00152 ATP synthase alpha and beta subunits signature. 282458009865 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009866 Pfam match to entry PF02874 ATP-synt_ab_N, ATP synthase alpha/beta family, beta-barrel domain, score 83.30, E-value 4.9e-21 282458009867 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 282458009868 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 282458009869 Pfam match to entry PF00213 OSCP, ATP synthase delta (OSCP) subunit, score 118.90, E-value 3.8e-34 282458009870 PS00389 ATP synthase delta (OSCP) subunit signature. 282458009871 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 282458009872 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 282458009873 Pfam match to entry PF00430 ATP-synt_B, ATP synthase B/B' CF(0), score 140.10, E-value 8.8e-39 282458009874 1 probable transmembrane helix predicted for SAR2195 by TMHMM2.0 at aa 7-29 282458009875 Signal peptide predicted for SAR2196 by SignalP 2.0 HMM (Signal peptide probabilty 0.889) with cleavage site probability 0.521 between residues 27 and 28; signal peptide 282458009876 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 282458009877 Pfam match to entry PF00137 ATP-synt_C, ATP synthase subunit C, score 106.60, E-value 4.9e-28 282458009878 2 probable transmembrane helices predicted for SAR2196 by TMHMM2.0 at aa 4-26 and 47-69 282458009879 PS00605 ATP synthase c subunit signature. 282458009880 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 282458009881 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 282458009882 Pfam match to entry PF00119 ATP-synt_A, ATP synthase A chain, score 197.40, E-value 2.2e-55 282458009883 5 probable transmembrane helices predicted for SAR2197 by TMHMM2.0 at aa 15-37, 81-103, 118-137, 171-193 and 208-230 282458009884 PS00449 ATP synthase a subunit signature. 282458009885 4 probable transmembrane helices predicted for SAR2198 by TMHMM2.0 at aa 12-29, 34-56, 69-86 and 91-113 282458009886 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 282458009887 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 282458009888 active site 282458009889 homodimer interface [polypeptide binding]; other site 282458009890 Pfam match to entry PF02350 Epimerase_2, UDP-N-acetylglucosamine 2-epimerase, score 630.90, E-value 7.3e-186 282458009891 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282458009892 active site 282458009893 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 37.10, E-value 4e-07 282458009894 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 282458009895 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 282458009896 dimer interface [polypeptide binding]; other site 282458009897 active site 282458009898 glycine-pyridoxal phosphate binding site [chemical binding]; other site 282458009899 folate binding site [chemical binding]; other site 282458009900 Pfam match to entry PF00464 SHMT, Serine hydroxymethyltransferase, score 887.40, E-value 3.2e-266 282458009901 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 282458009902 hypothetical protein; Provisional; Region: PRK13690 282458009903 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 282458009904 Low molecular weight phosphatase family; Region: LMWPc; cd00115 282458009905 active site 282458009906 Pfam match to entry PF01451 LMWPc, Low molecular weight phosphotyrosine protein phosphatase, score 74.70, E-value 1.9e-18 282458009907 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 282458009908 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 282458009909 Pfam match to entry PF01300 Sua5_yciO_yrdC, SUA5/yciO/yrdC family, score 209.40, E-value 5.3e-59 282458009910 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 282458009911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458009912 S-adenosylmethionine binding site [chemical binding]; other site 282458009913 PS00092 N-6 Adenine-specific DNA methylases signature. 282458009914 peptide chain release factor 1; Validated; Region: prfA; PRK00591 282458009915 This domain is found in peptide chain release factors; Region: PCRF; smart00937 282458009916 RF-1 domain; Region: RF-1; pfam00472 282458009917 Pfam match to entry PF00472 RF-1, Peptidyl-tRNA hydrolase domain, score 243.30, E-value 3.4e-69 282458009918 PS00745 Prokaryotic-type class I peptide chain release factors signature. 282458009919 thymidine kinase; Provisional; Region: PRK04296 282458009920 Pfam match to entry PF00265 TK, Thymidine kinase, score 255.30, E-value 8.3e-89 282458009921 PS00603 Thymidine kinase cellular-type signature. 282458009922 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009923 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 282458009924 Pfam match to entry PF01197 Ribosomal_L31, Ribosomal protein L31, score 77.90, E-value 2.1e-19 282458009925 PS01143 Ribosomal protein L31 signature. 282458009926 transcription termination factor Rho; Provisional; Region: rho; PRK09376 282458009927 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 282458009928 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 282458009929 RNA binding site [nucleotide binding]; other site 282458009930 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 282458009931 multimer interface [polypeptide binding]; other site 282458009932 Walker A motif; other site 282458009933 ATP binding site [chemical binding]; other site 282458009934 Walker B motif; other site 282458009935 Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain, score 226.20, E-value 4.8e-64 282458009936 PS00017 ATP/GTP-binding site motif A (P-loop). 282458009937 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 282458009938 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 282458009939 NAD binding site [chemical binding]; other site 282458009940 catalytic residues [active] 282458009941 Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase, score 595.20, E-value 4e-175 282458009942 PS00070 Aldehyde dehydrogenases cysteine active site. 282458009943 PS00687 Aldehyde dehydrogenases glutamic acid active site. 282458009944 Predicted transcriptional regulators [Transcription]; Region: COG1733 282458009945 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 282458009946 Pfam match to entry PF01638 DUF24, Protein of unknown function DUF24, score 35.80, E-value 2.6e-08 282458009947 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 282458009948 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 282458009949 hinge; other site 282458009950 active site 282458009951 Pfam match to entry PF00275 EPSP_syntase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase), score 365.00, E-value 7.7e-106 282458009952 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 282458009953 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 282458009954 intersubunit interface [polypeptide binding]; other site 282458009955 active site 282458009956 zinc binding site [ion binding]; other site 282458009957 Na+ binding site [ion binding]; other site 282458009958 Pfam match to entry PF01116 F_bP_aldolase, Fructose-bisphosphate aldolase class-II, score 512.80, E-value 2.5e-150 282458009959 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 282458009960 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 282458009961 CTP synthetase; Validated; Region: pyrG; PRK05380 282458009962 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 282458009963 Catalytic site [active] 282458009964 active site 282458009965 UTP binding site [chemical binding]; other site 282458009966 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 282458009967 active site 282458009968 putative oxyanion hole; other site 282458009969 catalytic triad [active] 282458009970 Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I, score 246.20, E-value 4.7e-70 282458009971 PS00442 Glutamine amidotransferases class-I active site. 282458009972 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 282458009973 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 282458009974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458009975 Coenzyme A binding pocket [chemical binding]; other site 282458009976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 282458009977 Coenzyme A binding pocket [chemical binding]; other site 282458009978 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 52.90, E-value 7.1e-12 282458009979 pantothenate kinase; Provisional; Region: PRK13317 282458009980 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 282458009981 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 282458009982 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 282458009983 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 282458009984 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 282458009985 metal binding site [ion binding]; metal-binding site 282458009986 Pfam match to entry PF01546 Peptidase_M20, Peptidase M20/M25/M40, score 14.90, E-value 0.0024 282458009987 Pfam match to entry PF01546 Peptidase_M20, Peptidase M20/M25/M40, score 7.30, E-value 0.35 282458009988 S-ribosylhomocysteinase; Provisional; Region: PRK02260 282458009989 Pfam match to entry PF02664 LuxS, LuxS protein, score 290.20, E-value 2.6e-83 282458009990 Predicted membrane protein [Function unknown]; Region: COG4270 282458009991 3 probable transmembrane helices predicted for SAR2223 by TMHMM2.0 at aa 4-21, 40-57 and 67-84 282458009992 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 282458009993 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 282458009994 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 282458009995 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 282458009996 Pfam match to entry PF00591 Glycos_transf_3, Glycosyl transferase, a/b domain, score 238.80, E-value 7.9e-68 282458009997 PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. 282458009998 Pfam match to entry PF02885 Glycos_trans_3N, Glycosyl transferase, helical bundle domain, score 95.00, E-value 1.5e-24 282458009999 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 282458010000 intersubunit interface [polypeptide binding]; other site 282458010001 active site 282458010002 catalytic residue [active] 282458010003 Pfam match to entry PF01791 DeoC, Deoxyribose-phosphate aldolase, score 350.10, E-value 2.5e-101 282458010004 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 282458010005 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 282458010006 Pfam match to entry PF01048 PNP_UDP_1, Phosphorylase, score 330.30, E-value 2.2e-95 282458010007 PS01232 Purine and other phosphorylases family 1 signature. 282458010008 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 282458010009 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 282458010010 dimerization interface [polypeptide binding]; other site 282458010011 DPS ferroxidase diiron center [ion binding]; other site 282458010012 ion pore; other site 282458010013 Pfam match to entry PF02047 DPS, Dps protein family, score 210.60, E-value 2.4e-59 282458010014 PS00818 Dps protein family signature 1. 282458010015 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 282458010016 EVE domain; Region: EVE; cl00728 282458010017 Signal peptide predicted for SAR2230 by SignalP 2.0 HMM (Signal peptide probabilty 0.810) with cleavage site probability 0.215 between residues 36 and 37; signal peptide 282458010018 3 probable transmembrane helices predicted for SAR2230 by TMHMM2.0 at aa 5-24, 29-47 and 52-74 282458010019 PS00443 Glutamine amidotransferases class-II active site. 282458010020 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 282458010021 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 282458010022 Pfam match to entry PF01238 PMI_typeI, Phosphomannose isomerase type I, score 73.10, E-value 5.7e-18 282458010023 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 282458010024 NADH(P)-binding; Region: NAD_binding_10; pfam13460 282458010025 NAD(P) binding site [chemical binding]; other site 282458010026 putative active site [active] 282458010027 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 282458010028 dimerization interface [polypeptide binding]; other site 282458010029 putative DNA binding site [nucleotide binding]; other site 282458010030 putative Zn2+ binding site [ion binding]; other site 282458010031 Pfam match to entry PF01022 HTH_5, Bacterial regulatory protein, arsR family, score 76.90, E-value 4.1e-19 282458010032 Predicted helix-turn-helix motif with score 1380 (+3.89 SD) at aa 40-61, sequence ASVGHISHQLNLSQSNVSHQLK 282458010033 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 282458010034 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 282458010035 6 probable transmembrane helices predicted for SAR2234 by TMHMM2.0 at aa 22-44, 54-73, 90-112, 127-145, 158-180 and 185-207 282458010036 Pfam match to entry PF01545 Cation_efflux, Cation efflux family, score 335.60, E-value 5.7e-97 282458010037 Signal peptide predicted for SAR2235 by SignalP 2.0 HMM (Signal peptide probabilty 0.761) with cleavage site probability 0.199 between residues 28 and 29; signal peptide 282458010038 6 probable transmembrane helices predicted for SAR2235 by TMHMM2.0 at aa 20-42, 66-88, 118-140, 173-195, 230-252 and 267-289 282458010039 Insertion sequence IS1272 282458010040 Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 4.6e-198, 99.088% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 1.3e-98, 51.731% id in 520 aa. Contains a frameshift after codon 336; transposase (pseudogene) 282458010041 similar to hypothetical protein; Doubtful CDS. No database matches 282458010042 1 probable transmembrane helix predicted for SAR2237 by TMHMM2.0 at aa 4-21 282458010043 Probable gene remnant. Similar to internal regions of Bacillus thuringiensis transposase for insertion sequence element IS232 SW:T232_BACTB (Q99335) (431 aa) fasta scores: E(): 1.7e-25, 43.75% id in 176 aa, and Bacillus stearothermophilus transposase for insertion sequence element IS5376 SW:TRA6_BACST (Q45618) (400 aa) fasta scores: E(): 0.00011, 30.72% id in 179 aa. Contains a nonsense mutation (amber) after codon 69 and a frameshift after codon 122;transposase (fragment) 282458010044 1 probable transmembrane helix predicted for SAR2238 by TMHMM2.0 at aa 104-121 282458010045 Syndecan domain; Region: Syndecan; pfam01034 282458010046 1 probable transmembrane helix predicted for SAR2239 by TMHMM2.0 at aa 4-21 282458010047 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 282458010048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458010049 active site 282458010050 motif I; other site 282458010051 motif II; other site 282458010052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458010053 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 25.20, E-value 0.0015 282458010054 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 282458010055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282458010056 Walker A/P-loop; other site 282458010057 ATP binding site [chemical binding]; other site 282458010058 Q-loop/lid; other site 282458010059 ABC transporter signature motif; other site 282458010060 Walker B; other site 282458010061 D-loop; other site 282458010062 H-loop/switch region; other site 282458010063 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 136.60, E-value 4.6e-37 282458010064 PS00017 ATP/GTP-binding site motif A (P-loop). 282458010065 PS00017 ATP/GTP-binding site motif A (P-loop). 282458010066 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 282458010067 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 282458010068 glutaminase active site [active] 282458010069 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 282458010070 dimer interface [polypeptide binding]; other site 282458010071 active site 282458010072 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 282458010073 dimer interface [polypeptide binding]; other site 282458010074 active site 282458010075 Pfam match to entry PF01380 SIS, SIS domain, score 75.00, E-value 1.6e-18 282458010076 Pfam match to entry PF01380 SIS, SIS domain, score 138.80, E-value 1e-37 282458010077 Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II, score 261.60, E-value 1.2e-88 282458010078 PS00443 Glutamine amidotransferases class-II active site. 282458010079 1 probable transmembrane helix predicted for SAR2243 by TMHMM2.0 at aa 33-50 282458010080 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 282458010081 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 282458010082 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 282458010083 active site 282458010084 P-loop; other site 282458010085 phosphorylation site [posttranslational modification] 282458010086 9 probable transmembrane helices predicted for SAR2244 by TMHMM2.0 at aa 21-43, 53-72, 93-115, 135-157, 164-186, 219-241, 248-270, 275-297 and 318-340 282458010087 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 282458010088 HTH domain; Region: HTH_11; pfam08279 282458010089 Mga helix-turn-helix domain; Region: Mga; pfam05043 282458010090 PRD domain; Region: PRD; pfam00874 282458010091 PRD domain; Region: PRD; pfam00874 282458010092 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 282458010093 active site 282458010094 P-loop; other site 282458010095 phosphorylation site [posttranslational modification] 282458010096 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 282458010097 active site 282458010098 phosphorylation site [posttranslational modification] 282458010099 Predicted helix-turn-helix motif with score 1504 (+4.31 SD) at aa 22-43, sequence ITIHDIAQQLAVSSRTIHRELK 282458010100 Predicted helix-turn-helix motif for SAR2245 with score 1415.000, SD 4.01 at aa 108-129, sequence VKQYSLAQEIGVSVQTLAKMLD 282458010101 Pfam match to entry PF00874 BglG_antitermin, Transcriptional antiterminator bglG family, score 27.20, E-value 1.5e-05 282458010102 Pfam match to entry PF00874 BglG_antitermin, Transcriptional antiterminator bglG family, score 19.20, E-value 7.6e-05 282458010103 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282458010104 active site 282458010105 phosphorylation site [posttranslational modification] 282458010106 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 232.20, E-value 7.5e-66 282458010107 PS00372 PTS EIIA domains phosphorylation site signature 2. 282458010108 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 282458010109 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 282458010110 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 282458010111 Pfam match to entry PF01232 Mannitol_dh, Mannitol dehydrogenase, score 316.10, E-value 3.8e-92 282458010112 PS00974 Mannitol dehydrogenases signature. 282458010113 Similar to Staphylococcus aureus cell wall protein essential for optimal methicillin resistance FmtB TR:Q9LCH2 (EMBL:AB025716) (2478 aa) fasta scores: E(): 0, 92.27% id in 2485 aa, and to Abiotrophia defectiva extracellular matrix binding protein Emb TR:O85472 (EMBL:AF067776) (2055 aa) fasta scores: E(): 3.7e-57, 27.11% id in 2076 aa. Contains a nonsense mutation (ochre) after codon 40. Probable LPXTG-sorted surface protein; surface anchored protein (pseudogene) 282458010114 Signal peptide predicted for SAR2248 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.333 between residues 64 and 65 282458010115 Insertion sequence IS1272 282458010116 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 282458010117 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458010118 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 282458010119 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458010120 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 282458010121 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 282458010122 active site 282458010123 substrate binding site [chemical binding]; other site 282458010124 metal binding site [ion binding]; metal-binding site 282458010125 Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase, C-terminal domain, score 31.80, E-value 1.6e-05 282458010126 Pfam match to entry PF02880 PGM_PMM_III, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III, score 95.90, E-value 8e-25 282458010127 Pfam match to entry PF02879 PGM_PMM_II, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II, score 92.20, E-value 1e-23 282458010128 Pfam match to entry PF02878 PGM_PMM_I, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I, score 148.50, E-value 1.2e-40 282458010129 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 282458010130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 282458010131 Signal peptide predicted for SAR2253 by SignalP 2.0 HMM (Signal peptide probabilty 0.943) with cleavage site probability 0.398 between residues 28 and 29; signal peptide 282458010132 YbbR-like protein; Region: YbbR; pfam07949 282458010133 YbbR-like protein; Region: YbbR; pfam07949 282458010134 1 probable transmembrane helix predicted for SAR2253 by TMHMM2.0 at aa 10-32 282458010135 TIGR00159 family protein; Region: TIGR00159 282458010136 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 282458010137 Pfam match to entry PF02457 DUF147, Domain of unknown function DUF147, score 251.20, E-value 1.5e-71 282458010138 2 probable transmembrane helices predicted for SAR2254 by TMHMM2.0 at aa 15-37 and 44-66 282458010139 Arginase family; Region: Arginase; cd09989 282458010140 active site 282458010141 Mn binding site [ion binding]; other site 282458010142 oligomer interface [polypeptide binding]; other site 282458010143 Pfam match to entry PF00491 arginase, Arginase, score 404.50, E-value 1e-117 282458010144 PS01053 Arginase signature 3. 282458010145 PS00148 Arginase signature 2. 282458010146 PS00147 Arginase signature 1. 282458010147 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 282458010148 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 282458010149 Walker A motif; other site 282458010150 Pfam match to entry PF00142 fer4_NifH, 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family, score 22.40, E-value 2e-05 282458010151 PS00017 ATP/GTP-binding site motif A (P-loop). 282458010152 Pfam match to entry PF01883 DUF59, Domain of unknown function DUF59, score -17.20, E-value 0.33 282458010153 N-terminus is similar to the N-terminal region of Escherichia coli multidrug resistance protein Y EmrY SW:EMRY_ECOLI (P52600) (512 aa) fasta scores: E(): 5.3e-27, 26.76% id in 426 aa. Similar to full length Bacillus subtilis hypothetical protein YcnB TR:P94422 (EMBL:D50453) (472 aa) fasta scores: E(): 3.7e-62, 40.04% id in 472 aa. Contains a frameshift after codon 114. Frameshift occurs at a poly G hexamer; transport protein (pseudogene) 282458010154 14 probable transmembrane helices predicted for SAR2257 by TMHMM2.0 at aa 13-32, 52-71, 80-99, 109-131, 138-160, 170-192, 204-221, 225-247, 267-289, 299-321, 333-352, 362-384, 404-426 and 446-468 282458010155 Signal peptide predicted for SAR2257 by SignalP 2.0 HMM (Signal peptide probabilty 0.972) with cleavage site probability 0.314 between residues 33 and 34 282458010156 Signal peptide predicted for SAR2259 by SignalP 2.0 HMM (Signal peptide probabilty 0.778) with cleavage site probability 0.420 between residues 26 and 27; signal peptide 282458010157 4 probable transmembrane helices predicted for SAR2259 by TMHMM2.0 at aa 15-37, 61-78, 93-115 and 120-139 282458010158 Signal peptide predicted for SAR2260 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.291 between residues 28 and 29; signal peptide 282458010159 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282458010160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458010161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 282458010162 putative substrate translocation pore; other site 282458010163 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -113.40, E-value 0.0094 282458010164 12 probable transmembrane helices predicted for SAR2260 by TMHMM2.0 at aa 7-29, 39-61, 68-90, 132-154, 161-183, 198-215, 220-237, 257-279, 322-340, 344-363, 384-406 and 416-438 282458010165 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 282458010166 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 282458010167 6 probable transmembrane helices predicted for SAR2261 by TMHMM2.0 at aa 32-54, 59-81, 117-139, 152-171, 175-197 and 204-226 282458010168 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 282458010169 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 282458010170 substrate binding site; other site 282458010171 dimerization interface; other site 282458010172 Pfam match to entry PF01704 UDPGP, UTP--glucose-1-phosphate uridylyltransferase, score 121.50, E-value 1.6e-32 282458010173 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 282458010174 4 probable transmembrane helices predicted for SAR2263 by TMHMM2.0 at aa 20-42, 62-84, 94-116 and 137-159 282458010175 Signal peptide predicted for SAR2265 by SignalP 2.0 HMM (Signal peptide probabilty 0.960) with cleavage site probability 0.767 between residues 35 and 36; signal peptide 282458010176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 282458010177 Nucleoside recognition; Region: Gate; pfam07670 282458010178 10 probable transmembrane helices predicted for SAR2265 by TMHMM2.0 at aa 9-31, 60-82, 95-117, 132-154, 216-235, 245-267, 330-352, 372-394, 401-423 and 433-455 282458010179 Signal peptide predicted for SAR2266 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.859 between residues 37 and 38; signal peptide 282458010180 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 282458010181 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282458010182 ABC-ATPase subunit interface; other site 282458010183 dimer interface [polypeptide binding]; other site 282458010184 putative PBP binding regions; other site 282458010185 Pfam match to entry PF01032 FecCD_family, FecCD transport family, score 385.40, E-value 5.7e-112 282458010186 8 probable transmembrane helices predicted for SAR2266 by TMHMM2.0 at aa 13-32, 52-74, 110-132, 142-164, 184-206, 234-256, 269-291 and 301-318 282458010187 Signal peptide predicted for SAR2267 by SignalP 2.0 HMM (Signal peptide probabilty 0.917) with cleavage site probability 0.763 between residues 42 and 43; signal peptide 282458010188 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 282458010189 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282458010190 ABC-ATPase subunit interface; other site 282458010191 dimer interface [polypeptide binding]; other site 282458010192 putative PBP binding regions; other site 282458010193 8 probable transmembrane helices predicted for SAR2267 by TMHMM2.0 at aa 21-43, 70-92, 105-124, 128-150, 206-228, 248-279, 286-308 and 318-340 282458010194 Pfam match to entry PF01032 FecCD_family, FecCD transport family, score 410.60, E-value 1.5e-119 282458010195 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 282458010196 Signal peptide predicted for SAR2268 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.413 between residues 30 and 31; signal peptide 282458010197 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 282458010198 siderophore binding site; other site 282458010199 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 196.90, E-value 3.1e-55 282458010200 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458010201 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 282458010202 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 282458010203 dimer interface [polypeptide binding]; other site 282458010204 active site 282458010205 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 282458010206 substrate binding site [chemical binding]; other site 282458010207 catalytic residue [active] 282458010208 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 282458010209 IucA / IucC family; Region: IucA_IucC; pfam04183 282458010210 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 282458010211 H+ Antiporter protein; Region: 2A0121; TIGR00900 282458010212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458010213 putative substrate translocation pore; other site 282458010214 11 probable transmembrane helices predicted for SAR2271 by TMHMM2.0 at aa 5-27, 34-56, 76-98, 137-159, 163-185, 213-235, 245-267, 274-292, 296-313, 333-355 and 359-381 282458010215 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 282458010216 IucA / IucC family; Region: IucA_IucC; pfam04183 282458010217 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 282458010218 Asp23 family; Region: Asp23; pfam03780 282458010219 Small integral membrane protein [Function unknown]; Region: COG5547 282458010220 2 probable transmembrane helices predicted for SAR2274 by TMHMM2.0 at aa 22-41 and 45-64 282458010221 Signal peptide predicted for SAR2275 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.627 between residues 29 and 30; signal peptide 282458010222 2 probable transmembrane helices predicted for SAR2275 by TMHMM2.0 at aa 7-26 and 41-63 282458010223 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 282458010224 Signal peptide predicted for SAR2276 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.605 between residues 24 and 25; signal peptide 282458010225 Pfam match to entry PF02028 BCCT, BCCT family transporter, score 780.20, E-value 7.9e-231 282458010226 12 probable transmembrane helices predicted for SAR2276 by TMHMM2.0 at aa 5-27, 42-64, 85-107, 137-159, 188-210, 225-247, 260-282, 313-335, 348-370, 394-416, 437-459 and 463-485 282458010227 PS01303 BCCT family of transporters signature. 282458010228 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 282458010229 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 282458010230 putative NAD(P) binding site [chemical binding]; other site 282458010231 dimer interface [polypeptide binding]; other site 282458010232 Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases, score 165.90, E-value 6.8e-46 282458010233 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 282458010234 Prostaglandin dehydrogenases; Region: PGDH; cd05288 282458010235 NAD(P) binding site [chemical binding]; other site 282458010236 substrate binding site [chemical binding]; other site 282458010237 dimer interface [polypeptide binding]; other site 282458010238 Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases, score 131.70, E-value 1.4e-35 282458010239 Signal peptide predicted for SAR2279 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.654 between residues 29 and 30; signal peptide 282458010240 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 282458010241 1 probable transmembrane helix predicted for SAR2279 by TMHMM2.0 at aa 4-26 282458010242 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 282458010243 beta-galactosidase; Region: BGL; TIGR03356 282458010244 Pfam match to entry PF00232 Glyco_hydro_1, Glycosyl hydrolase 1, score 910.00, E-value 6.8e-270 282458010245 PS00572 Glycosyl hydrolases family 1 active site. 282458010246 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 282458010247 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 282458010248 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 282458010249 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 282458010250 active site 282458010251 P-loop; other site 282458010252 phosphorylation site [posttranslational modification] 282458010253 Pfam match to entry PF02302 PTS_IIB, PTS system, Lactose/Cellobiose specific IIB subunit, score 134.70, E-value 1.6e-36 282458010254 10 probable transmembrane helices predicted for SAR2281 by TMHMM2.0 at aa 31-53, 73-91, 104-121, 136-158, 181-198, 218-240, 283-305, 333-355, 362-384 and 389-411 282458010255 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score -96.10, E-value 0.03 282458010256 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 282458010257 methionine cluster; other site 282458010258 active site 282458010259 phosphorylation site [posttranslational modification] 282458010260 metal binding site [ion binding]; metal-binding site 282458010261 Pfam match to entry PF02255 PTS_IIA, PTS system, Lactose/Cellobiose specific IIA subunit, score 210.90, E-value 1.9e-59 282458010262 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 282458010263 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 282458010264 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 282458010265 putative substrate binding site [chemical binding]; other site 282458010266 putative ATP binding site [chemical binding]; other site 282458010267 Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 222.60, E-value 5.7e-63 282458010268 PS00584 pfkB family of carbohydrate kinases signature 2. 282458010269 PS00583 pfkB family of carbohydrate kinases signature 1. 282458010270 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 282458010271 Pfam match to entry PF02502 LacAB_rpiB, Ribose/Galactose Isomerase, score 164.80, E-value 1.5e-45 282458010272 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 282458010273 Pfam match to entry PF02502 LacAB_rpiB, Ribose/Galactose Isomerase, score 129.50, E-value 6.2e-35 282458010274 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 282458010275 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 282458010276 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 282458010277 Pfam match to entry PF00455 deoR, Bacterial regulatory proteins, deoR family, score 418.40, E-value 6.6e-122 282458010278 PS00894 Bacterial regulatory proteins, deoR family signature. 282458010279 NAD-dependent deacetylase; Provisional; Region: PRK00481 282458010280 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 282458010281 NAD+ binding site [chemical binding]; other site 282458010282 substrate binding site [chemical binding]; other site 282458010283 putative Zn binding site [ion binding]; other site 282458010284 Pfam match to entry PF02146 SIR2, Sir2 family, score 300.90, E-value 1.5e-86 282458010285 PS00190 Cytochrome c family heme-binding site signature. 282458010286 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 282458010287 1 probable transmembrane helix predicted for SAR2289a by TMHMM2.0 at aa 4-26 282458010288 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 282458010289 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 282458010290 active site 282458010291 catalytic tetrad [active] 282458010292 Pfam match to entry PF00248 aldo_ket_red, Aldo/keto reductase, score 358.70, E-value 4.5e-106 282458010293 PS00063 Aldo/keto reductase active site signature. 282458010294 PS00062 Aldo/keto reductase signature 2. 282458010295 PS00798 Aldo/keto reductase signature 1. 282458010296 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 282458010297 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 282458010298 DNA binding residues [nucleotide binding] 282458010299 putative dimer interface [polypeptide binding]; other site 282458010300 Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family, score 39.30, E-value 9e-08 282458010301 Predicted helix-turn-helix motif with score 1484 (+4.24 SD) at aa 1-22, sequence MKTKEVVALMNISQDTLRYYEK 282458010302 Signal peptide predicted for SAR2292 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.558 between residues 30 and 31; signal peptide 282458010303 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 282458010304 substrate binding site [chemical binding]; other site 282458010305 catalytic residues [active] 282458010306 Pfam match to entry PF02278 Lyase_8, Polysaccharide lyase 8, super-sandwich domain, score 503.90, E-value 1.2e-147 282458010307 Pfam match to entry PF02884 Lyase_8_C, Polysaccharide lyase 8, C-terminal beta-sandwich domain, score 126.40, E-value 5.4e-34 282458010308 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 282458010309 Peptidase family M23; Region: Peptidase_M23; pfam01551 282458010310 Pfam match to entry PF01551 Peptidase_M37, Peptidase M23/M37, score 56.90, E-value 4.2e-13 282458010311 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 282458010312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 282458010313 active site 282458010314 motif I; other site 282458010315 motif II; other site 282458010316 Signal peptide predicted for SAR2295 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.862 between residues 30 and 31; signal peptide 282458010317 MAP domain; Region: MAP; pfam03642 282458010318 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 282458010319 acetolactate synthase; Reviewed; Region: PRK08617 282458010320 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 282458010321 PYR/PP interface [polypeptide binding]; other site 282458010322 dimer interface [polypeptide binding]; other site 282458010323 TPP binding site [chemical binding]; other site 282458010324 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 282458010325 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 282458010326 TPP-binding site [chemical binding]; other site 282458010327 Pfam match to entry PF02775 TPP_enzymes_C, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 248.50, E-value 9.5e-71 282458010328 PS00187 Thiamine pyrophosphate enzymes signature. 282458010329 Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzyme, central domain, score 89.80, E-value 5.4e-23 282458010330 Pfam match to entry PF02776 TPP_enzymes_N, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 234.90, E-value 1.1e-66 282458010331 2 probable transmembrane helices predicted for SAR2297b by TMHMM2.0 at aa 10-29 and 34-56 282458010332 Probable remnant. Similar to the C-terminal regions of Thermotoga maritima 30S ribosomal protein S9 TM1453 SW:RS9_THEMA (Q9X1G4) (134 aa) fasta scores: E(): 0.0075, 51.28% id in 39 aa, and Bacillus subtilis 30S ribosomal protein S9 RpsI SW:RS9_BACSU (P21470) (129 aa) fasta scores: E(): 0.031, 51.51% id in 33 aa;hypothetical protein (fragment) 282458010333 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 282458010334 Divergent AAA domain; Region: AAA_4; pfam04326 282458010335 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 282458010336 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 282458010337 putative DNA binding site [nucleotide binding]; other site 282458010338 putative Zn2+ binding site [ion binding]; other site 282458010339 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 282458010340 Pfam match to entry PF00380 Ribosomal_S9, Ribosomal protein S9/S16, score 200.50, E-value 1.1e-61 282458010341 PS00360 Ribosomal protein S9 signature. 282458010342 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 282458010343 23S rRNA interface [nucleotide binding]; other site 282458010344 L3 interface [polypeptide binding]; other site 282458010345 Pfam match to entry PF00572 Ribosomal_L13, Ribosomal protein L13, score 271.50, E-value 1.1e-77 282458010346 PS00783 Ribosomal protein L13 signature. 282458010347 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 282458010348 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 282458010349 dimerization interface 3.5A [polypeptide binding]; other site 282458010350 active site 282458010351 Pfam match to entry PF01416 PseudoU_synth_1, tRNA pseudouridine synthase, score 238.00, E-value 1.3e-67 282458010352 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 282458010353 4 probable transmembrane helices predicted for SAR2303 by TMHMM2.0 at aa 28-50, 65-87, 107-129 and 248-267 282458010354 Pfam match to entry PF02361 CbiQ, Cobalt transport protein, score 213.70, E-value 2.8e-60 282458010355 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 282458010356 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 282458010357 Walker A/P-loop; other site 282458010358 ATP binding site [chemical binding]; other site 282458010359 Q-loop/lid; other site 282458010360 ABC transporter signature motif; other site 282458010361 Walker B; other site 282458010362 D-loop; other site 282458010363 H-loop/switch region; other site 282458010364 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 199.90, E-value 3.9e-56 282458010365 PS00211 ABC transporters family signature. 282458010366 PS00017 ATP/GTP-binding site motif A (P-loop). 282458010367 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 282458010368 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 282458010369 Walker A/P-loop; other site 282458010370 ATP binding site [chemical binding]; other site 282458010371 Q-loop/lid; other site 282458010372 ABC transporter signature motif; other site 282458010373 Walker B; other site 282458010374 D-loop; other site 282458010375 H-loop/switch region; other site 282458010376 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 192.00, E-value 9.7e-54 282458010377 PS00211 ABC transporters family signature. 282458010378 PS00017 ATP/GTP-binding site motif A (P-loop). 282458010379 insertion sequence ISZ 282458010380 Transposase; Region: HTH_Tnp_1; cl17663 282458010381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 282458010382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 282458010383 Helix-turn-helix domain; Region: HTH_28; pfam13518 282458010384 Pfam match to entry PF01527 Transposase_8, Transposase, score 47.20, E-value 3.6e-10 282458010385 Predicted helix-turn-helix motif with score 2127 (+6.43 SD) at aa 155-176, sequence QSYREVAEHFNISYGQIYQWVH 282458010386 insertion sequence ISY 282458010387 HTH-like domain; Region: HTH_21; pfam13276 282458010388 Integrase core domain; Region: rve; pfam00665 282458010389 Integrase core domain; Region: rve_3; cl15866 282458010390 Pfam match to entry PF00665 rve, Integrase core domain, score 95.20, E-value 2.4e-26 282458010391 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 282458010392 Pfam match to entry PF01196 Ribosomal_L17, Ribosomal protein L17, score 184.40, E-value 1.8e-51 282458010393 PS01167 Ribosomal protein L17 signature. 282458010394 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 282458010395 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 282458010396 alphaNTD homodimer interface [polypeptide binding]; other site 282458010397 alphaNTD - beta interaction site [polypeptide binding]; other site 282458010398 alphaNTD - beta' interaction site [polypeptide binding]; other site 282458010399 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 282458010400 Pfam match to entry PF01000 RNA_pol_A_bac, Bacterial RNA polymerase, alpha chain, score 528.30, E-value 5.6e-155 282458010401 30S ribosomal protein S11; Validated; Region: PRK05309 282458010402 Pfam match to entry PF00411 Ribosomal_S11, Ribosomal protein S11, score 249.40, E-value 1e-76 282458010403 PS00054 Ribosomal protein S11 signature. 282458010404 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 282458010405 30S ribosomal protein S13; Region: bact_S13; TIGR03631 282458010406 Pfam match to entry PF00416 Ribosomal_S13, Ribosomal protein S13/S18, score 199.10, E-value 7e-56 282458010407 PS00646 Ribosomal protein S13 signature. 282458010408 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 282458010409 Pfam match to entry PF00444 Ribosomal_L36, Ribosomal protein L36, score 71.10, E-value 1.7e-22 282458010410 PS00828 Ribosomal protein L36 signature. 282458010411 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 282458010412 rRNA binding site [nucleotide binding]; other site 282458010413 predicted 30S ribosome binding site; other site 282458010414 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 57.80, E-value 2.2e-14 282458010415 adenylate kinase; Reviewed; Region: adk; PRK00279 282458010416 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 282458010417 AMP-binding site [chemical binding]; other site 282458010418 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 282458010419 Pfam match to entry PF00406 adenylatekinase, Adenylate kinase, score 409.40, E-value 3.5e-119 282458010420 PS00113 Adenylate kinase signature. 282458010421 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 282458010422 Signal peptide predicted for SAR2315 by SignalP 2.0 HMM (Signal peptide probabilty 0.712) with cleavage site probability 0.549 between residues 52 and 53; signal peptide 282458010423 SecY translocase; Region: SecY; pfam00344 282458010424 Pfam match to entry PF00344 secY, eubacterial secY protein, score 645.90, E-value 2.2e-190 282458010425 10 probable transmembrane helices predicted for SAR2315 by TMHMM2.0 at aa 17-39, 68-90, 111-133, 146-168, 175-197, 217-239, 260-282, 309-331, 362-384 and 394-411 282458010426 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 282458010427 PS00756 Protein secY signature 2. 282458010428 PS00755 Protein secY signature 1. 282458010429 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 282458010430 Pfam match to entry PF00256 L15, Ribosomal protein L15, score 53.80, E-value 3.1e-18 282458010431 PS00475 Ribosomal protein L15 signature. 282458010432 Pfam match to entry PF01305 Ribosomal_L15, Ribosomal protein L15 amino terminal region, score 214.50, E-value 1.6e-60 282458010433 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 282458010434 23S rRNA binding site [nucleotide binding]; other site 282458010435 Pfam match to entry PF00327 Ribosomal_L30, Ribosomal protein L30p/L7e, score 68.50, E-value 2.6e-19 282458010436 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 282458010437 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 282458010438 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 282458010439 Pfam match to entry PF00333 Ribosomal_S5, Ribosomal protein S5, score 275.40, E-value 7.4e-79 282458010440 PS00585 Ribosomal protein S5 signature. 282458010441 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 282458010442 5S rRNA interface [nucleotide binding]; other site 282458010443 L27 interface [polypeptide binding]; other site 282458010444 23S rRNA interface [nucleotide binding]; other site 282458010445 L5 interface [polypeptide binding]; other site 282458010446 Pfam match to entry PF00861 Ribosomal_L18p, Ribosomal L18p/L5e family, score 179.70, E-value 4.7e-50 282458010447 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 282458010448 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 282458010449 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 282458010450 Pfam match to entry PF00347 Ribosomal_L6, Ribosomal protein L6, score 275.30, E-value 4.8e-79 282458010451 PS00525 Ribosomal protein L6 signature 1. 282458010452 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 282458010453 Pfam match to entry PF00410 Ribosomal_S8, Ribosomal protein S8, score 259.80, E-value 1.1e-78 282458010454 PS00053 Ribosomal protein S8 signature. 282458010455 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 282458010456 Pfam match to entry PF00253 Ribosomal_S14, Ribosomal protein S14p/S29e, score 96.40, E-value 1.7e-28 282458010457 PS00527 Ribosomal protein S14 signature. 282458010458 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 282458010459 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 282458010460 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 282458010461 Pfam match to entry PF00673 Ribosomal_L5_C, ribosomal L5P family C-terminus, score 203.60, E-value 2.9e-57 282458010462 Pfam match to entry PF00281 Ribosomal_L5, Ribosomal protein L5, score 123.20, E-value 4.7e-33 282458010463 PS00358 Ribosomal protein L5 signature. 282458010464 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 282458010465 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 282458010466 RNA binding site [nucleotide binding]; other site 282458010467 Pfam match to entry PF00467 Ribosomal_L24, KOW motif, score 95.40, E-value 1.1e-24 282458010468 PS01108 Ribosomal protein L24 signature. 282458010469 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 282458010470 Pfam match to entry PF00238 Ribosomal_L14, Ribosomal protein L14p/L23e, score 266.90, E-value 2.6e-76 282458010471 PS00049 Ribosomal protein L14 signature. 282458010472 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 282458010473 Pfam match to entry PF00366 Ribosomal_S17, Ribosomal protein S17, score 135.50, E-value 4.4e-39 282458010474 PS00056 Ribosomal protein S17 signature. 282458010475 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 282458010476 23S rRNA interface [nucleotide binding]; other site 282458010477 putative translocon interaction site; other site 282458010478 signal recognition particle (SRP54) interaction site; other site 282458010479 L23 interface [polypeptide binding]; other site 282458010480 trigger factor interaction site; other site 282458010481 Pfam match to entry PF00831 Ribosomal_L29, Ribosomal L29 protein, score 100.30, E-value 3.9e-26 282458010482 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 282458010483 23S rRNA interface [nucleotide binding]; other site 282458010484 5S rRNA interface [nucleotide binding]; other site 282458010485 putative antibiotic binding site [chemical binding]; other site 282458010486 L25 interface [polypeptide binding]; other site 282458010487 L27 interface [polypeptide binding]; other site 282458010488 Pfam match to entry PF00252 Ribosomal_L16, Ribosomal protein L16, score 293.80, E-value 5.2e-85 282458010489 PS00701 Ribosomal protein L16 signature 2. 282458010490 PS00586 Ribosomal protein L16 signature 1. 282458010491 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 282458010492 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 282458010493 G-X-X-G motif; other site 282458010494 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 282458010495 Pfam match to entry PF00189 Ribosomal_S3_C, Ribosomal protein S3, C-terminal domain., score 174.80, E-value 7.6e-54 282458010496 PS00548 Ribosomal protein S3 signature. 282458010497 Pfam match to entry PF00013 KH-domain, KH domain, score 41.00, E-value 2.6e-08 282458010498 Pfam match to entry PF00417 Ribosomal_S3_N, Ribosomal protein S3, N-terminal domain., score 112.30, E-value 5.2e-35 282458010499 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 282458010500 putative translocon binding site; other site 282458010501 protein-rRNA interface [nucleotide binding]; other site 282458010502 Pfam match to entry PF00237 Ribosomal_L22, Ribosomal protein L22p/L17e, score 210.40, E-value 2.7e-59 282458010503 PS00464 Ribosomal protein L22 signature. 282458010504 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 282458010505 Pfam match to entry PF00203 Ribosomal_S19, Ribosomal protein S19, score 180.20, E-value 1.3e-51 282458010506 PS00323 Ribosomal protein S19 signature. 282458010507 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 282458010508 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 282458010509 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 282458010510 Pfam match to entry PF00181 Ribosomal_L2, Ribosomal Proteins L2, score 480.70, E-value 1.2e-140 282458010511 PS00467 Ribosomal protein L2 signature. 282458010512 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 282458010513 Pfam match to entry PF00276 Ribosomal_L23, Ribosomal protein L23, score 128.70, E-value 7.4e-37 282458010514 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 282458010515 Pfam match to entry PF00573 Ribosomal_L4, Ribosomal protein L4/L1 family, score 281.60, E-value 1e-80 282458010516 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 282458010517 Pfam match to entry PF00297 Ribosomal_L3, Ribosomal protein L3, score 291.60, E-value 9.7e-84 282458010518 PS00474 Ribosomal protein L3 signature. 282458010519 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 282458010520 Pfam match to entry PF00338 Ribosomal_S10, Ribosomal protein S10p/S20e, score 204.60, E-value 1.5e-57 282458010521 PS00361 Ribosomal protein S10 signature. 282458010522 Signal peptide predicted for SAR2337 by SignalP 2.0 HMM (Signal peptide probabilty 0.664) with cleavage site probability 0.246 between residues 31 and 32; signal peptide 282458010523 4 probable transmembrane helices predicted for SAR2337 by TMHMM2.0 at aa 12-34, 38-60, 67-89 and 93-115 282458010524 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 282458010525 Signal peptide predicted for SAR2338 by SignalP 2.0 HMM (Signal peptide probabilty 0.606) with cleavage site probability 0.346 between residues 41 and 42; signal peptide 282458010526 13 probable transmembrane helices predicted for SAR2338 by TMHMM2.0 at aa 20-42, 57-76, 83-105, 110-132, 141-163, 178-195, 202-221, 252-274, 295-317, 322-344, 349-371, 391-413 and 425-442 282458010527 Pfam match to entry PF00860 xan_ur_permease, Xanthine/uracil permeases family, score 79.80, E-value 5.7e-20 282458010528 DNA topoisomerase III; Provisional; Region: PRK07726 282458010529 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 282458010530 active site 282458010531 putative interdomain interaction site [polypeptide binding]; other site 282458010532 putative metal-binding site [ion binding]; other site 282458010533 putative nucleotide binding site [chemical binding]; other site 282458010534 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 282458010535 domain I; other site 282458010536 DNA binding groove [nucleotide binding] 282458010537 phosphate binding site [ion binding]; other site 282458010538 domain II; other site 282458010539 domain III; other site 282458010540 nucleotide binding site [chemical binding]; other site 282458010541 catalytic site [active] 282458010542 domain IV; other site 282458010543 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 282458010544 Pfam match to entry PF01396 zf-C4_Topoisom, Topoisomerase DNA binding C4 zinc finger, score 14.30, E-value 0.025 282458010545 Pfam match to entry PF01131 Topoisom_bac, DNA topoisomerase, score 301.90, E-value 7.6e-87 282458010546 Pfam match to entry PF01751 Toprim, Toprim domain, score 76.70, E-value 4.7e-19 282458010547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458010548 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 282458010549 Coenzyme A binding pocket [chemical binding]; other site 282458010550 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 32.10, E-value 1.3e-05 282458010551 Signal peptide predicted for SAR2341 by SignalP 2.0 HMM (Signal peptide probabilty 0.763) with cleavage site probability 0.364 between residues 26 and 27; signal peptide 282458010552 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 282458010553 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 282458010554 9 probable transmembrane helices predicted for SAR2341 by TMHMM2.0 at aa 7-29, 34-53, 60-77, 114-136, 157-179, 184-201, 208-230, 235-257 and 269-286 282458010555 Predicted permeases [General function prediction only]; Region: COG0679 282458010556 10 probable transmembrane helices predicted for SAR2342 by TMHMM2.0 at aa 5-24, 31-48, 58-80, 89-111, 116-138, 158-180, 190-211, 223-242, 252-269 and 276-298 282458010557 4 probable transmembrane helices predicted for SAR2344 by TMHMM2.0 at aa 4-21, 28-50, 55-73 and 82-104 282458010558 Signal peptide predicted for SAR2345 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.738 between residues 30 and 31; signal peptide 282458010559 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 282458010560 Protein export membrane protein; Region: SecD_SecF; cl14618 282458010561 Pfam match to entry PF00873 ACR_tran, AcrB/AcrD/AcrF family, score 289.50, E-value 4.1e-83 282458010562 12 probable transmembrane helices predicted for SAR2345 by TMHMM2.0 at aa 13-32, 369-391, 398-415, 420-438, 476-498, 508-530, 561-583, 886-908, 913-935, 945-967, 988-1008 and 1023-1045 282458010563 Pfam match to entry PF00873 ACR_tran, AcrB/AcrD/AcrF family, score 463.70, E-value 1.5e-135 282458010564 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 282458010565 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 282458010566 Pfam match to entry PF02388 FemAB, FemAB family, score 134.20, E-value 2.3e-36 282458010567 Signal peptide predicted for SAR2347 by SignalP 2.0 HMM (Signal peptide probabilty 0.697) with cleavage site probability 0.553 between residues 29 and 30; signal peptide 282458010568 3 probable transmembrane helices predicted for SAR2347 by TMHMM2.0 at aa 5-27, 31-50 and 57-79 282458010569 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 282458010570 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 282458010571 Pfam match to entry PF01047 MarR, MarR family, score 52.00, E-value 1.3e-11 282458010572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458010573 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282458010574 putative substrate translocation pore; other site 282458010575 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -121.80, E-value 0.019 282458010576 12 probable transmembrane helices predicted for SAR2350 by TMHMM2.0 at aa 20-42, 52-71, 83-100, 113-135, 142-164, 168-190, 225-247, 252-274, 283-302, 307-326, 347-369 and 374-393 282458010577 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282458010578 Transcriptional regulators [Transcription]; Region: MarR; COG1846 282458010579 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 282458010580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282458010581 FeS/SAM binding site; other site 282458010582 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 282458010583 Pfam match to entry PF01444 MoaA_NifB_PqqE, moaA / nifB / pqqE family, score 262.00, E-value 8.2e-75 282458010584 PS01305 moaA / nifB / pqqE family signature. 282458010585 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 282458010586 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 282458010587 GTP binding site; other site 282458010588 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 282458010589 MoaE interaction surface [polypeptide binding]; other site 282458010590 MoeB interaction surface [polypeptide binding]; other site 282458010591 thiocarboxylated glycine; other site 282458010592 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 282458010593 MoaE homodimer interface [polypeptide binding]; other site 282458010594 MoaD interaction [polypeptide binding]; other site 282458010595 active site residues [active] 282458010596 Pfam match to entry PF02391 MoeA, Molydopterin converting factor subunit 2, score 195.20, E-value 1e-54 282458010597 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 282458010598 PS00017 ATP/GTP-binding site motif A (P-loop). 282458010599 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 282458010600 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 282458010601 dimer interface [polypeptide binding]; other site 282458010602 putative functional site; other site 282458010603 putative MPT binding site; other site 282458010604 Pfam match to entry PF00994 MoCF_biosynth, Molybdenum cofactor biosynthesis protein, score 585.10, E-value 4.3e-172 282458010605 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 282458010606 trimer interface [polypeptide binding]; other site 282458010607 dimer interface [polypeptide binding]; other site 282458010608 putative active site [active] 282458010609 Pfam match to entry PF01967 MoaC, MoaC family, score 262.00, E-value 8e-75 282458010610 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 282458010611 MPT binding site; other site 282458010612 trimer interface [polypeptide binding]; other site 282458010613 PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 282458010614 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 282458010615 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 282458010616 ATP binding site [chemical binding]; other site 282458010617 substrate interface [chemical binding]; other site 282458010618 PS00017 ATP/GTP-binding site motif A (P-loop). 282458010619 Pfam match to entry PF00899 ThiF_family, ThiF family, score 151.50, E-value 1.5e-41 282458010620 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282458010621 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 282458010622 Walker A/P-loop; other site 282458010623 ATP binding site [chemical binding]; other site 282458010624 Q-loop/lid; other site 282458010625 ABC transporter signature motif; other site 282458010626 Walker B; other site 282458010627 D-loop; other site 282458010628 H-loop/switch region; other site 282458010629 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 167.30, E-value 2.6e-46 282458010630 PS00211 ABC transporters family signature. 282458010631 PS00017 ATP/GTP-binding site motif A (P-loop). 282458010632 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 282458010633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458010634 dimer interface [polypeptide binding]; other site 282458010635 conserved gate region; other site 282458010636 putative PBP binding loops; other site 282458010637 ABC-ATPase subunit interface; other site 282458010638 5 probable transmembrane helices predicted for SAR2362 by TMHMM2.0 at aa 10-32, 45-67, 82-104, 145-167 and 193-215 282458010639 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 66.70, E-value 5e-16 282458010640 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 282458010641 Signal peptide predicted for SAR2363 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.402 between residues 23 and 24; signal peptide 282458010642 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 282458010643 substrate binding pocket [chemical binding]; other site 282458010644 membrane-bound complex binding site; other site 282458010645 hinge residues; other site 282458010646 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458010647 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 282458010648 Pfam match to entry PF02634 FdhD-NarQ, FdhD/NarQ family, score 309.20, E-value 4.9e-89 282458010649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458010650 Coenzyme A binding pocket [chemical binding]; other site 282458010651 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 39.40, E-value 8.1e-08 282458010652 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 282458010653 Signal peptide predicted for SAR2366 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.367 between residues 31 and 32; signal peptide 282458010654 Pfam match to entry PF02632 BioY, BioY family, score 106.50, E-value 5e-28 282458010655 6 probable transmembrane helices predicted for SAR2366 by TMHMM2.0 at aa 7-25, 29-48, 55-74, 78-100, 112-134 and 149-171 282458010656 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 282458010657 active site 282458010658 dimerization interface [polypeptide binding]; other site 282458010659 Pfam match to entry PF01156 IU_nuc_hydro, Inosine-uridine preferring nucleoside hydrolase, score 93.50, E-value 4.4e-24 282458010660 Signal peptide predicted for SAR2368 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.601 between residues 28 and 29; signal peptide 282458010661 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 282458010662 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 282458010663 intersubunit interface [polypeptide binding]; other site 282458010664 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 122.50, E-value 8.1e-33 282458010665 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458010666 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 282458010667 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 282458010668 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 282458010669 1 probable transmembrane helix predicted for SAR2370 by TMHMM2.0 at aa 7-26 282458010670 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 282458010671 8 probable transmembrane helices predicted for SAR2371 by TMHMM2.0 at aa 21-43, 89-106, 113-135, 171-193, 198-215, 225-242, 249-267 and 272-294 282458010672 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 282458010673 alpha-gamma subunit interface [polypeptide binding]; other site 282458010674 beta-gamma subunit interface [polypeptide binding]; other site 282458010675 Pfam match to entry PF00547 urease_gamma, Urease, gamma subunit, score 201.90, E-value 5.9e-61 282458010676 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 282458010677 gamma-beta subunit interface [polypeptide binding]; other site 282458010678 alpha-beta subunit interface [polypeptide binding]; other site 282458010679 Pfam match to entry PF00699 Urease_beta, Urease beta subunit., score 232.10, E-value 8.2e-66 282458010680 urease subunit alpha; Reviewed; Region: ureC; PRK13207 282458010681 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 282458010682 subunit interactions [polypeptide binding]; other site 282458010683 active site 282458010684 flap region; other site 282458010685 Pfam match to entry PF00449 urease, Urease alpha-subunit, N-terminal domain, score 314.90, E-value 9.4e-91 282458010686 PS00017 ATP/GTP-binding site motif A (P-loop). 282458010687 PS01120 Urease nickel ligands signature. 282458010688 Pfam match to entry PF02802 urease_C, Urease alpha-subunit, catalytic domain, score 1126.60, E-value 0 282458010689 PS00145 Urease active site. 282458010690 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 282458010691 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 282458010692 dimer interface [polypeptide binding]; other site 282458010693 catalytic residues [active] 282458010694 Pfam match to entry PF02814 UreE, UreE urease accessory protein, score 165.40, E-value 9.4e-46 282458010695 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 282458010696 UreF; Region: UreF; pfam01730 282458010697 Pfam match to entry PF01730 UreF, UreF, score 242.80, E-value 4.7e-69 282458010698 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 282458010699 Pfam match to entry PF01495 HypB_UreG, HypB/UreG nucleotide-binding domain, score 275.00, E-value 9.4e-79 282458010700 PS00017 ATP/GTP-binding site motif A (P-loop). 282458010701 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 282458010702 Pfam match to entry PF01774 UreD, UreD urease accessory protein, score 209.80, E-value 4.1e-59 282458010703 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282458010704 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282458010705 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282458010706 Transcriptional regulators [Transcription]; Region: MarR; COG1846 282458010707 Helix-turn-helix domain; Region: HTH_18; pfam12833 282458010708 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 282458010709 Predicted helix-turn-helix motif with score 1261 (+3.48 SD) at aa 313-334, sequence YTIKQIIQRLGVNPENLHIIVT 282458010710 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 57.90, E-value 2.2e-13 282458010711 Signal peptide predicted for SAR2383 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.985 between residues 27 and 28; signal peptide 282458010712 Surface antigen [General function prediction only]; Region: COG3942 282458010713 CHAP domain; Region: CHAP; pfam05257 282458010714 Signal peptide predicted for SAR2385 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.489 between residues 42 and 43; signal peptide 282458010715 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 282458010716 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 282458010717 10 probable transmembrane helices predicted for SAR2385 by TMHMM2.0 at aa 7-29, 33-53, 66-88, 108-130, 187-209, 229-251, 258-276, 310-332, 352-383 and 433-455 282458010718 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 282458010719 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 282458010720 Pfam match to entry PF02317 Octopine_DH, NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain, score 44.40, E-value 2.6e-09 282458010721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 282458010722 3 probable transmembrane helices predicted for SAR2387 by TMHMM2.0 at aa 22-44, 65-87 and 92-123 282458010723 Signal peptide predicted for SAR2388 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.875 between residues 27 and 28; signal peptide 282458010724 Surface antigen [General function prediction only]; Region: COG3942 282458010725 CHAP domain; Region: CHAP; pfam05257 282458010726 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 282458010727 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 282458010728 putative ligand binding site [chemical binding]; other site 282458010729 putative NAD binding site [chemical binding]; other site 282458010730 catalytic site [active] 282458010731 Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 35.20, E-value 1.5e-06 282458010732 Pfam match to entry PF02826 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 234.50, E-value 1.6e-66 282458010733 PS00017 ATP/GTP-binding site motif A (P-loop). 282458010734 Signal peptide predicted for SAR2390 by SignalP 2.0 HMM (Signal peptide probabilty 0.813) with cleavage site probability 0.370 between residues 30 and 31; signal peptide 282458010735 hypothetical protein; Provisional; Region: PRK06753 282458010736 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 282458010737 Pfam match to entry PF01360 Monooxygenase, Monooxygenase, score 113.20, E-value 5.1e-30 282458010738 Signal peptide predicted for SAR2391 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.703 between residues 34 and 35; signal peptide 282458010739 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 282458010740 Lysozyme subfamily 2; Region: LYZ2; smart00047 282458010741 Pfam match to entry PF01832 Amidase_4, N-acetylmuramoyl-L-alanine amidase, score 129.90, E-value 4.7e-35 282458010742 1 probable transmembrane helix predicted for SAR2391 by TMHMM2.0 at aa 7-26 282458010743 Signal peptide predicted for SAR2391a by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.771 between residues 39 and 40; signal peptide 282458010744 3 probable transmembrane helices predicted for SAR2391a by TMHMM2.0 at aa 12-29, 34-53 and 60-82 282458010745 Uncharacterized conserved protein [Function unknown]; Region: COG2427 282458010746 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 282458010747 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 282458010748 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 282458010749 4Fe-4S binding domain; Region: Fer4; pfam00037 282458010750 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 282458010751 [4Fe-4S] binding site [ion binding]; other site 282458010752 molybdopterin cofactor binding site; other site 282458010753 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 282458010754 molybdopterin cofactor binding site; other site 282458010755 Pfam match to entry PF01568 Molydop_binding, Molydopterin dinucleotide binding domain, score 106.60, E-value 4.7e-28 282458010756 Pfam match to entry PF00384 molybdopterin, Molybdopterin oxidoreductases, score 420.40, E-value 1.7e-122 282458010757 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 282458010758 Pfam match to entry PF00037 fer4, 4Fe-4S binding domain, score 30.90, E-value 2.9e-05 282458010759 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 282458010760 Pfam match to entry PF00037 fer4, 4Fe-4S binding domain, score 13.30, E-value 0.022 282458010761 Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains, score 25.80, E-value 0.001 282458010762 Signal peptide predicted for SAR2394 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.854 between residues 34 and 35; signal peptide 282458010763 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 282458010764 1 probable transmembrane helix predicted for SAR2394 by TMHMM2.0 at aa 15-34 282458010765 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 282458010766 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 282458010767 active site 282458010768 Pfam match to entry PF00459 inositol_P, Inositol monophosphatase, score 92.60, E-value 9.2e-25 282458010769 Predicted transcriptional regulator [Transcription]; Region: COG2378 282458010770 HTH domain; Region: HTH_11; pfam08279 282458010771 Pfam match to entry PF00455 deoR, Bacterial regulatory proteins, deoR family, score 29.10, E-value 4.2e-07 282458010772 Predicted helix-turn-helix motif with score 1386 (+3.91 SD) at aa 20-41, sequence MTALELAKYCNVSKRTILRDID 282458010773 CAAX protease self-immunity; Region: Abi; pfam02517 282458010774 7 probable transmembrane helices predicted for SAR2397 by TMHMM2.0 at aa 19-41, 51-73, 92-114, 139-161, 173-192, 196-215 and 222-244 282458010775 Pfam match to entry PF02517 Abi, CAAX amino terminal protease, score 64.70, E-value 1.9e-15 282458010776 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 282458010777 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 282458010778 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 282458010779 putative active site [active] 282458010780 Pfam match to entry PF01418 HTH_6, Helix-turn-helix domain, rpiR family, score 91.60, E-value 1.6e-23 282458010781 Predicted helix-turn-helix motif with score 978 (+2.52 SD) at aa 36-57, sequence MRSQDLASLLDISTSSVIRFSK 282458010782 Pfam match to entry PF01380 SIS, SIS domain, score 43.20, E-value 5.7e-09 282458010783 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 282458010784 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score 499.70, E-value 2.3e-146 282458010785 11 probable transmembrane helices predicted for SAR2400 by TMHMM2.0 at aa 15-32, 39-61, 122-141, 153-175, 195-217, 237-259, 269-291, 329-351, 361-383, 404-426 and 431-449 282458010786 PS00218 Amino acid permeases signature. 282458010787 4 probable transmembrane helices predicted for SAR2401 by TMHMM2.0 at aa 12-29, 33-55, 67-86 and 90-109 282458010788 Signal peptide predicted for SAR2402 by SignalP 2.0 HMM (Signal peptide probabilty 0.948) with cleavage site probability 0.786 between residues 30 and 31; signal peptide 282458010789 2 probable transmembrane helices predicted for SAR2402 by TMHMM2.0 at aa 5-24 and 39-58 282458010790 Signal peptide predicted for SAR2403 by SignalP 2.0 HMM (Signal peptide probabilty 0.645) with cleavage site probability 0.498 between residues 28 and 29; signal peptide 282458010791 2 probable transmembrane helices predicted for SAR2403 by TMHMM2.0 at aa 5-27 and 37-59 282458010792 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 282458010793 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458010794 active site 282458010795 motif I; other site 282458010796 motif II; other site 282458010797 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 108.00, E-value 1.8e-28 282458010798 Similar to an internal region of Homo sapiens ileal sodium/bile acid cotransporter SLC10A2 SW:NTCI_HUMAN (Q12908) (348 aa) fasta scores: E(): 4.6e-21, 34.76% id in 256 aa, and to the full length Bacillus subtilis transporter YocS TR:O34524 (EMBL:AF027868) (321 aa) fasta scores: E(): 3.5e-59, 54.07% id in 307 aa. Contains a nonsense mutation (ochre) after codon 178;sodium/bile acid symporter family protein (pseudogene) 282458010799 9 probable transmembrane helices predicted for SAR2405 by TMHMM2.0 at aa 5-27, 37-54, 67-86, 96-118, 125-147, 162-181, 188-210, 220-242 and 263-285 282458010800 Pfam match to entry PF01758 SBF, Sodium Bile acid symporter family, score 114.10, E-value 2.7e-30 282458010801 Signal peptide predicted for SAR2405 by SignalP 2.0 HMM (Signal peptide probabilty 0.951) with cleavage site probability 0.344 between residues 36 and 37 282458010802 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 282458010803 Signal peptide predicted for SAR2408 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.436 between residues 41 and 42; signal peptide 282458010804 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282458010805 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282458010806 active site turn [active] 282458010807 phosphorylation site [posttranslational modification] 282458010808 PS00017 ATP/GTP-binding site motif A (P-loop). 282458010809 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 57.90, E-value 3.6e-15 282458010810 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282458010811 10 probable transmembrane helices predicted for SAR2408 by TMHMM2.0 at aa 7-29, 56-78, 85-107, 127-149, 170-192, 202-219, 304-321, 326-343, 350-372 and 382-404 282458010812 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 349.60, E-value 3.4e-101 282458010813 PS00079 Multicopper oxidases signature 1. 282458010814 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 282458010815 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 282458010816 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 282458010817 putative active site [active] 282458010818 Pfam match to entry PF01418 HTH_6, Helix-turn-helix domain, rpiR family, score 49.70, E-value 6.5e-11 282458010819 Predicted helix-turn-helix motif with score 1106 (+2.95 SD) at aa 35-56, sequence MKIQDLAQFTHASNATIHRFTR 282458010820 Pfam match to entry PF01380 SIS, SIS domain, score 13.30, E-value 0.0083 282458010821 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 282458010822 putative hydrophobic ligand binding site [chemical binding]; other site 282458010823 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 282458010824 10 probable transmembrane helices predicted for SAR2411 by TMHMM2.0 at aa 31-50, 54-73, 86-108, 128-150, 162-184, 219-241, 253-286, 309-328, 348-370 and 424-446 282458010825 Signal peptide predicted for SAR2412 by SignalP 2.0 HMM (Signal peptide probabilty 0.967) with cleavage site probability 0.190 between residues 44 and 45; signal peptide 282458010826 6 probable transmembrane helices predicted for SAR2412 by TMHMM2.0 at aa 3-25, 30-49, 65-87, 92-114, 139-158 and 162-181 282458010827 oxidoreductase; Provisional; Region: PRK07985 282458010828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 282458010829 NAD(P) binding site [chemical binding]; other site 282458010830 active site 282458010831 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 171.30, E-value 1.6e-47 282458010832 PS00061 Short-chain dehydrogenases/reductases family signature. 282458010833 Similar to an internal region of Arabidopsis thaliana IAA-amino acid hydrolase 3 precursor IAR3 SW:ILR3_ARATH (P54969) (438 aa) fasta scores: E(): 3.5e-37, 36.43% id in 365 aa, and to the full length Zymomonas mobilis amino acid amido hydrolase TR:Q9FDK6 (EMBL:AF212041) (380 aa) fasta scores: E(): 7.3e-58, 43.16% id in 373 aa. Contains a nonsense mutation (ochre) after codon 302; peptidase (pseudogene) 282458010834 Pfam match to entry PF01546 Peptidase_M20, Peptidase M20/M25/M40, score 154.80, E-value 1.8e-43 282458010835 imidazolonepropionase; Validated; Region: PRK09356 282458010836 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 282458010837 active site 282458010838 urocanate hydratase; Provisional; Region: PRK05414 282458010839 Pfam match to entry PF01175 Urocanase, Urocanase, score 1177.90, E-value 0 282458010840 Transcriptional regulator [Transcription]; Region: LysR; COG0583 282458010841 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 282458010842 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 282458010843 dimerization interface [polypeptide binding]; other site 282458010844 Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 103.60, E-value 3.8e-27 282458010845 Predicted helix-turn-helix motif with score 1212 (+3.31 SD) at aa 16-37, sequence NSFTKAAQFLHISQPSLTATIK 282458010846 PS00044 Bacterial regulatory proteins, lysR family signature. 282458010847 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 282458010848 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 282458010849 active site 282458010850 metal binding site [ion binding]; metal-binding site 282458010851 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 58.20, E-value 1.5e-15 282458010852 formimidoylglutamase; Provisional; Region: PRK13775 282458010853 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 282458010854 putative active site [active] 282458010855 putative metal binding site [ion binding]; other site 282458010856 Pfam match to entry PF00491 arginase, Arginase, score 17.80, E-value 2.1e-10 282458010857 PS00148 Arginase signature 2. 282458010858 PS00147 Arginase signature 1. 282458010859 Signal peptide predicted for SAR2421 by SignalP 2.0 HMM (Signal peptide probabilty 0.752) with cleavage site probability 0.370 between residues 33 and 34; signal peptide 282458010860 CAAX protease self-immunity; Region: Abi; pfam02517 282458010861 8 probable transmembrane helices predicted for SAR2421 by TMHMM2.0 at aa 7-29, 41-63, 83-105, 115-137, 150-172, 176-195, 202-221 and 231-253 282458010862 Pfam match to entry PF02517 Abi, CAAX amino terminal protease, score 24.10, E-value 0.00035 282458010863 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 282458010864 tetramer (dimer of dimers) interface [polypeptide binding]; other site 282458010865 active site 282458010866 dimer interface [polypeptide binding]; other site 282458010867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 282458010868 MOSC domain; Region: MOSC; pfam03473 282458010869 3-alpha domain; Region: 3-alpha; pfam03475 282458010870 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 282458010871 active site 282458010872 catalytic residues [active] 282458010873 Pfam match to entry PF01263 Aldose_epim, Aldose 1-epimerase, score 90.90, E-value 2.6e-23 282458010874 PS00545 Aldose 1-epimerase active site. 282458010875 Uncharacterized conserved protein [Function unknown]; Region: COG1742 282458010876 Pfam match to entry PF02694 UPF0060, Uncharacterized BCR, YnfA/UPF0060 family, score 190.30, E-value 3e-53 282458010877 4 probable transmembrane helices predicted for SAR2425 by TMHMM2.0 at aa 4-26, 33-55, 60-79 and 86-105 282458010878 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 282458010879 Signal peptide predicted for SAR2426 by SignalP 2.0 HMM (Signal peptide probabilty 0.616) with cleavage site probability 0.210 between residues 40 and 41; signal peptide 282458010880 7 probable transmembrane helices predicted for SAR2426 by TMHMM2.0 at aa 21-38, 178-200, 235-257, 277-299, 312-331, 336-355 and 367-386 282458010881 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 282458010882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282458010883 Walker A/P-loop; other site 282458010884 ATP binding site [chemical binding]; other site 282458010885 Q-loop/lid; other site 282458010886 ABC transporter signature motif; other site 282458010887 Walker B; other site 282458010888 D-loop; other site 282458010889 H-loop/switch region; other site 282458010890 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 282458010891 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 187.20, E-value 2.5e-52 282458010892 PS00211 ABC transporters family signature. 282458010893 PS00017 ATP/GTP-binding site motif A (P-loop). 282458010894 Predicted membrane protein [Function unknown]; Region: COG3152 282458010895 4 probable transmembrane helices predicted for SAR2428 by TMHMM2.0 at aa 36-58, 68-90, 110-129 and 144-166 282458010896 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 282458010897 active site 282458010898 DNA binding site [nucleotide binding] 282458010899 Pfam match to entry PF02245 Pur_DNA_glyco, Methylpurine-DNA glycosylase (MPG), score 158.90, E-value 8.7e-44 282458010900 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 282458010901 11 probable transmembrane helices predicted for SAR2430 by TMHMM2.0 at aa 5-27, 34-56, 66-88, 95-117, 158-180, 219-236, 240-262, 282-304, 308-330, 339-361 and 376-398 282458010902 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 282458010903 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 282458010904 homotetramer interface [polypeptide binding]; other site 282458010905 FMN binding site [chemical binding]; other site 282458010906 homodimer contacts [polypeptide binding]; other site 282458010907 putative active site [active] 282458010908 putative substrate binding site [chemical binding]; other site 282458010909 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 282458010910 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 282458010911 oligomer interface [polypeptide binding]; other site 282458010912 metal binding site [ion binding]; metal-binding site 282458010913 metal binding site [ion binding]; metal-binding site 282458010914 putative Cl binding site [ion binding]; other site 282458010915 aspartate ring; other site 282458010916 basic sphincter; other site 282458010917 hydrophobic gate; other site 282458010918 periplasmic entrance; other site 282458010919 Pfam match to entry PF01544 CorA, CorA-like Mg2+ transporter protein, score 177.90, E-value 1.6e-49 282458010920 2 probable transmembrane helices predicted for SAR2432 by TMHMM2.0 at aa 255-277 and 287-309 282458010921 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 282458010922 active site 282458010923 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 282458010924 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 282458010925 4 probable transmembrane helices predicted for SAR2436 by TMHMM2.0 at aa 32-54, 105-127, 134-156 and 183-205 282458010926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458010927 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 282458010928 putative substrate translocation pore; other site 282458010929 15 probable transmembrane helices predicted for SAR2437 by TMHMM2.0 at aa 5-25, 143-165, 180-202, 209-231, 236-258, 271-290, 295-317, 330-347, 362-379, 400-422, 427-449, 456-475, 490-512, 533-550 and 601-623 282458010930 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -109.40, E-value 0.0068 282458010931 Signal peptide predicted for SAR2438 by SignalP 2.0 HMM (Signal peptide probabilty 0.881) with cleavage site probability 0.551 between residues 32 and 33; signal peptide 282458010932 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 282458010933 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 282458010934 lipoyl-biotinyl attachment site [posttranslational modification]; other site 282458010935 HlyD family secretion protein; Region: HlyD_3; pfam13437 282458010936 1 probable transmembrane helix predicted for SAR2438 by TMHMM2.0 at aa 4-26 282458010937 Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 25.70, E-value 6.6e-05 282458010938 Predicted helix-turn-helix motif with score 1145 (+3.09 SD) at aa 25-46, sequence ISTKMICAYCNINRSTFYDYYK 282458010939 Probable gene remnant. Similar to the N-terminal regions of Staphylococcus intermedius IS1182 transposase TR:Q9EZC2 (EMBL:AF299292) (224 aa) fasta scores: E(): 4.1e-07, 37.5% id in 72 aa, and Staphylococcus haemolyticus hypothetical protein TR:Q54270 (EMBL:U35635) (273 aa) fasta scores: E(): 4.9e-22, 81.94% id in 72 aa;conserved hypothetical protein (fragment) 282458010940 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 282458010941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458010942 putative substrate translocation pore; other site 282458010943 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -88.80, E-value 0.0013 282458010944 11 probable transmembrane helices predicted for SAR2441 by TMHMM2.0 at aa 13-35, 50-69, 81-103, 139-161, 168-186, 222-244, 257-279, 289-311, 313-335, 350-367 and 374-393 282458010945 Predicted membrane protein [Function unknown]; Region: COG4640 282458010946 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 282458010947 1 probable transmembrane helix predicted for SAR2442 by TMHMM2.0 at aa 51-70 282458010948 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 282458010949 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 282458010950 putative Zn2+ binding site [ion binding]; other site 282458010951 putative DNA binding site [nucleotide binding]; other site 282458010952 Pfam match to entry PF01047 MarR, MarR family, score 40.10, E-value 4.9e-08 282458010953 Predicted helix-turn-helix motif with score 1618 (+4.70 SD) at aa 52-73, sequence LTISEITQRQGVNKAAVSRRIK 282458010954 Uncharacterized conserved protein [Function unknown]; Region: COG1434 282458010955 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 282458010956 putative active site [active] 282458010957 6 probable transmembrane helices predicted for SAR2444 by TMHMM2.0 at aa 5-27, 29-46, 50-67, 88-110, 115-137 and 298-320 282458010958 Pfam match to entry PF02698 DUF218, Uncharacterized ACR, COG1434, score -13.10, E-value 4.6e-05 282458010959 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 282458010960 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282458010961 Walker A/P-loop; other site 282458010962 ATP binding site [chemical binding]; other site 282458010963 Q-loop/lid; other site 282458010964 ABC transporter signature motif; other site 282458010965 Walker B; other site 282458010966 D-loop; other site 282458010967 H-loop/switch region; other site 282458010968 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 194.30, E-value 1.9e-54 282458010969 PS00017 ATP/GTP-binding site motif A (P-loop). 282458010970 Signal peptide predicted for SAR2446 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.557 between residues 41 and 42; signal peptide 282458010971 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 282458010972 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 282458010973 FtsX-like permease family; Region: FtsX; pfam02687 282458010974 Pfam match to entry PF02687 DUF214, Predicted permease, score 24.80, E-value 1.3e-05 282458010975 4 probable transmembrane helices predicted for SAR2446 by TMHMM2.0 at aa 13-35, 232-254, 274-296 and 316-338 282458010976 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282458010977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458010978 active site 282458010979 phosphorylation site [posttranslational modification] 282458010980 intermolecular recognition site; other site 282458010981 dimerization interface [polypeptide binding]; other site 282458010982 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282458010983 DNA binding site [nucleotide binding] 282458010984 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 114.80, E-value 1.6e-30 282458010985 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 96.90, E-value 1.1e-27 282458010986 Signal peptide predicted for SAR2448 by SignalP 2.0 HMM (Signal peptide probabilty 0.628) with cleavage site probability 0.284 between residues 32 and 33; signal peptide 282458010987 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 282458010988 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 282458010989 dimerization interface [polypeptide binding]; other site 282458010990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282458010991 dimer interface [polypeptide binding]; other site 282458010992 phosphorylation site [posttranslational modification] 282458010993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458010994 ATP binding site [chemical binding]; other site 282458010995 Mg2+ binding site [ion binding]; other site 282458010996 G-X-G motif; other site 282458010997 2 probable transmembrane helices predicted for SAR2448 by TMHMM2.0 at aa 10-32 and 165-187 282458010998 Pfam match to entry PF00672 HAMP, HAMP domain, score 51.30, E-value 2.1e-11 282458010999 Pfam match to entry PF00512 signal, His Kinase A (phosphoacceptor) domain, score 43.10, E-value 6.4e-09 282458011000 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 117.30, E-value 2.9e-31 282458011001 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 282458011002 LytTr DNA-binding domain; Region: LytTR; smart00850 282458011003 Signal peptide predicted for SAR2450 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.866 between residues 27 and 28; signal peptide 282458011004 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 282458011005 4 probable transmembrane helices predicted for SAR2450 by TMHMM2.0 at aa 7-26, 53-75, 87-109 and 114-133 282458011006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 282458011007 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 282458011008 1 probable transmembrane helix predicted for SAR2451 by TMHMM2.0 at aa 145-163 282458011009 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 282458011010 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 282458011011 Walker A/P-loop; other site 282458011012 ATP binding site [chemical binding]; other site 282458011013 Q-loop/lid; other site 282458011014 ABC transporter signature motif; other site 282458011015 Walker B; other site 282458011016 D-loop; other site 282458011017 H-loop/switch region; other site 282458011018 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 180.40, E-value 3e-50 282458011019 PS00017 ATP/GTP-binding site motif A (P-loop). 282458011020 PS00211 ABC transporters family signature. 282458011021 Signal peptide predicted for SAR2453 by SignalP 2.0 HMM (Signal peptide probabilty 0.926) with cleavage site probability 0.741 between residues 41 and 42; signal peptide 282458011022 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 282458011023 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 282458011024 6 probable transmembrane helices predicted for SAR2453 by TMHMM2.0 at aa 21-39, 167-189, 210-232, 245-267, 274-296 and 332-354 282458011025 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 282458011026 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 282458011027 Signal peptide predicted for SAR2455 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.930 between residues 40 and 41; signal peptide 282458011028 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 282458011029 L-lactate permease; Region: Lactate_perm; cl00701 282458011030 13 probable transmembrane helices predicted for SAR2455 by TMHMM2.0 at aa 12-34, 38-60, 67-89, 127-149, 156-178, 193-215, 228-245, 250-267, 295-317, 349-371, 392-414, 429-448 and 512-529 282458011031 Pfam match to entry PF02652 Lactate_perm, L-lactate permease, score 677.50, E-value 6.8e-200 282458011032 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 282458011033 Signal peptide predicted for SAR2457 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.433 between residues 19 and 20; signal peptide 282458011034 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458011035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458011036 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 282458011037 Coenzyme A binding pocket [chemical binding]; other site 282458011038 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 75.20, E-value 1.3e-18 282458011039 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 282458011040 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 282458011041 NAD(P) binding site [chemical binding]; other site 282458011042 Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases, score 129.50, E-value 6.2e-35 282458011043 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458011044 Coenzyme A binding pocket [chemical binding]; other site 282458011045 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 53.50, E-value 4.8e-12 282458011046 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 282458011047 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 282458011048 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282458011049 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 85.40, E-value 1.2e-21 282458011050 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 282458011051 4 probable transmembrane helices predicted for SAR2462 by TMHMM2.0 at aa 5-22, 37-56, 68-90 and 105-127 282458011052 Predicted membrane protein [Function unknown]; Region: COG1511 282458011053 Signal peptide predicted for SAR2463 by SignalP 2.0 HMM (Signal peptide probabilty 0.958) with cleavage site probability 0.372 between residues 28 and 29; signal peptide 282458011054 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 282458011055 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 282458011056 6 probable transmembrane helices predicted for SAR2463 by TMHMM2.0 at aa 9-31, 236-258, 271-293, 308-330, 337-356 and 391-413 282458011057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 282458011058 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 282458011059 Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 27.80, E-value 1.8e-05 282458011060 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 282458011061 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 282458011062 Cl binding site [ion binding]; other site 282458011063 oligomer interface [polypeptide binding]; other site 282458011064 Pfam match to entry PF01544 CorA, CorA-like Mg2+ transporter protein, score 91.70, E-value 1.5e-23 282458011065 2 probable transmembrane helices predicted for SAR2465 by TMHMM2.0 at aa 260-282 and 287-309 282458011066 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 282458011067 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282458011068 active site turn [active] 282458011069 phosphorylation site [posttranslational modification] 282458011070 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282458011071 8 probable transmembrane helices predicted for SAR2466 by TMHMM2.0 at aa 112-134, 154-176, 183-205, 264-286, 299-321, 347-369, 404-423 and 447-469 282458011072 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 324.60, E-value 1.2e-93 282458011073 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 63.00, E-value 1.1e-16 282458011074 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282458011075 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 282458011076 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 282458011077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 282458011078 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 79.30, E-value 8.1e-20 282458011079 Predicted helix-turn-helix motif with score 1732 (+5.09 SD) at aa 164-185, sequence LSLKDIAMHCNISESYCSNLFV 282458011080 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 282458011081 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 282458011082 Signal peptide predicted for SAR2470 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.435 between residues 34 and 35; signal peptide 282458011083 1 probable transmembrane helix predicted for SAR2470 by TMHMM2.0 at aa 7-29 282458011084 Insertion sequence IS1272 282458011085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 282458011086 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458011087 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 282458011088 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 282458011089 Signal peptide predicted for SAR2472 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.457 between residues 34 and 35; signal peptide 282458011090 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 282458011091 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 282458011092 Pfam match to entry PF00375 SDF, Sodium:dicarboxylate symporter family, score 554.50, E-value 7.3e-163 282458011093 8 probable transmembrane helices predicted for SAR2472 by TMHMM2.0 at aa 9-31, 46-68, 81-103, 159-176, 204-226, 231-253, 323-345 and 360-382 282458011094 PS00713 Sodium:dicarboxylate symporter family signature 1. 282458011095 Signal peptide predicted for SAR2473 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.701 between residues 32 and 33; signal peptide 282458011096 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 282458011097 1 probable transmembrane helix predicted for SAR2473 by TMHMM2.0 at aa 7-26 282458011098 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 282458011099 MarR family; Region: MarR_2; pfam12802 282458011100 Pfam match to entry PF01047 MarR, MarR family, score 62.50, E-value 8.8e-15 282458011101 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 282458011102 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 282458011103 putative dimer interface [polypeptide binding]; other site 282458011104 Pfam match to entry PF00011 HSP20, Hsp20/alpha crystallin family, score 38.90, E-value 1.8e-09 282458011105 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 282458011106 Signal peptide predicted for SAR2476 by SignalP 2.0 HMM (Signal peptide probabilty 0.780) with cleavage site probability 0.457 between residues 36 and 37; signal peptide 282458011107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458011108 putative substrate translocation pore; other site 282458011109 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -105.70, E-value 0.005 282458011110 12 probable transmembrane helices predicted for SAR2476 by TMHMM2.0 at aa 12-34, 44-63, 70-89, 99-121, 134-156, 161-180, 205-227, 242-259, 266-288, 292-314, 326-348 and 358-380 282458011111 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 282458011112 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282458011113 Similar to Streptomyces coelicolor transcriptional activator TipA SW:TIPA_STRCO (P32184) (253 aa) fasta scores: E(): 0.0013, 24.08% id in 245 aa, and to Streptococcus pneumoniae regulator of pmra mta or sp0739 TR:Q9RIN0 (EMBL:AJ239034) (246 aa) fasta scores: E(): 7.1e-08, 28.16% id in 245 aa. Contains a nonsense mutation (ochre) after codon 95;MerR family regulatory protein (pseudogene) 282458011114 Predicted helix-turn-helix motif with score 1346 (+3.77 SD) at aa 5-26, sequence YTLKDIIEITGVTKRTLHYYDE 282458011115 Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family, score 41.20, E-value 2.3e-08 282458011116 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 282458011117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458011118 active site 282458011119 phosphorylation site [posttranslational modification] 282458011120 intermolecular recognition site; other site 282458011121 dimerization interface [polypeptide binding]; other site 282458011122 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 282458011123 DNA binding residues [nucleotide binding] 282458011124 dimerization interface [polypeptide binding]; other site 282458011125 Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family, score 95.70, E-value 9.1e-25 282458011126 PS00622 Bacterial regulatory proteins, luxR family signature. 282458011127 Predicted helix-turn-helix motif with score 1054 (+2.78 SD) at aa 170-191, sequence YGNKEIAEKLFVSVKTVEAHKT 282458011128 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 120.30, E-value 3.7e-32 282458011129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 282458011130 Histidine kinase; Region: HisKA_3; pfam07730 282458011131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458011132 ATP binding site [chemical binding]; other site 282458011133 Mg2+ binding site [ion binding]; other site 282458011134 G-X-G motif; other site 282458011135 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 59.10, E-value 5.6e-15 282458011136 PS00430 TonB-dependent receptor proteins signature 1. 282458011137 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 282458011138 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 282458011139 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 282458011140 Pfam match to entry PF02665 Nitrate_red_gam, Nitrate reductase gamma subunit, score 264.20, E-value 1.7e-75 282458011141 5 probable transmembrane helices predicted for SAR2483 by TMHMM2.0 at aa 4-26, 47-69, 84-106, 126-148 and 185-207 282458011142 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 282458011143 Pfam match to entry PF02613 Nitrate_red_del, Nitrate reductase delta subunit, score 32.70, E-value 1.3e-07 282458011144 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 282458011145 PS00190 Cytochrome c family heme-binding site signature. 282458011146 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 282458011147 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 282458011148 [4Fe-4S] binding site [ion binding]; other site 282458011149 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 282458011150 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 282458011151 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 282458011152 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 282458011153 molybdopterin cofactor binding site; other site 282458011154 Pfam match to entry PF01568 Molydop_binding, Molydopterin dinucleotide binding domain, score 131.40, E-value 1.7e-35 282458011155 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 282458011156 Pfam match to entry PF00384 molybdopterin, Molybdopterin oxidoreductases, score 300.30, E-value 2.4e-86 282458011157 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 282458011158 Pfam match to entry PF00384 molybdopterin, Molybdopterin oxidoreductases, score 33.90, E-value 1.5e-08 282458011159 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 282458011160 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 282458011161 active site 282458011162 SAM binding site [chemical binding]; other site 282458011163 homodimer interface [polypeptide binding]; other site 282458011164 Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases., score 182.20, E-value 8.5e-51 282458011165 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 282458011166 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 282458011167 [2Fe-2S] cluster binding site [ion binding]; other site 282458011168 Pfam match to entry PF00355 Rieske, Rieske [2Fe-2S] domain, score 55.80, E-value 9.6e-13 282458011169 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 282458011170 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 282458011171 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282458011172 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 282458011173 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 282458011174 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 282458011175 Pfam match to entry PF01077 NIR_SIR, Nitrite and sulphite reductase 4Fe-4S domain, score 87.10, E-value 3.7e-22 282458011176 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 282458011177 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 250.30, E-value 2.6e-71 282458011178 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 282458011179 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 282458011180 putative active site [active] 282458011181 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 282458011182 active site 282458011183 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 282458011184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458011185 Coenzyme A binding pocket [chemical binding]; other site 282458011186 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 282458011187 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 53.30, E-value 5.4e-12 282458011188 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 282458011189 Pfam match to entry PF01226 Form_Nir_trans, Formate/nitrite transporter, score 77.00, E-value 3.8e-19 282458011190 6 probable transmembrane helices predicted for SAR2493 by TMHMM2.0 at aa 38-60, 75-97, 117-139, 165-187, 200-222 and 242-264 282458011191 2 probable transmembrane helices predicted for SAR2494 by TMHMM2.0 at aa 5-24 and 34-56 282458011192 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 282458011193 putative hydrophobic ligand binding site [chemical binding]; other site 282458011194 Signal peptide predicted for SAR2496 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.678 between residues 22 and 23; signal peptide 282458011195 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 282458011196 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 282458011197 intersubunit interface [polypeptide binding]; other site 282458011198 YodA lipocalin-like domain; Region: YodA; pfam09223 282458011199 Pfam match to entry PF01297 Lipoprotein_4, Periplasmic solute binding protein family, score 221.30, E-value 1.5e-62 282458011200 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458011201 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 282458011202 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 282458011203 Pfam match to entry PF02604 DUF172, Uncharacterized ACR, COG2161, score 77.30, E-value 3.2e-19 282458011204 PS00017 ATP/GTP-binding site motif A (P-loop). 282458011205 Signal peptide predicted for SAR2499 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.933 between residues 25 and 26; signal peptide 282458011206 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 282458011207 Thioredoxin; Region: Thioredoxin_4; cl17273 282458011208 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458011209 Signal peptide predicted for SAR2500 by SignalP 2.0 HMM (Signal peptide probabilty 0.964) with cleavage site probability 0.627 between residues 26 and 27; signal peptide 282458011210 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458011211 FemAB family; Region: FemAB; pfam02388 282458011212 Pfam match to entry PF02388 FemAB, FemAB family, score 746.30, E-value 1.3e-220 282458011213 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 282458011214 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 282458011215 Walker A/P-loop; other site 282458011216 ATP binding site [chemical binding]; other site 282458011217 Q-loop/lid; other site 282458011218 ABC transporter signature motif; other site 282458011219 Walker B; other site 282458011220 D-loop; other site 282458011221 H-loop/switch region; other site 282458011222 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 244.60, E-value 1.4e-69 282458011223 PS00211 ABC transporters family signature. 282458011224 PS00017 ATP/GTP-binding site motif A (P-loop). 282458011225 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 282458011226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458011227 dimer interface [polypeptide binding]; other site 282458011228 conserved gate region; other site 282458011229 putative PBP binding loops; other site 282458011230 ABC-ATPase subunit interface; other site 282458011231 4 probable transmembrane helices predicted for SAR2503 by TMHMM2.0 at aa 30-52, 65-87, 102-121 and 207-229 282458011232 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 72.20, E-value 1.1e-17 282458011233 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282458011234 Signal peptide predicted for SAR2504 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.371 between residues 24 and 25; signal peptide 282458011235 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 282458011236 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 282458011237 substrate binding pocket [chemical binding]; other site 282458011238 membrane-bound complex binding site; other site 282458011239 hinge residues; other site 282458011240 Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3, score 205.40, E-value 8.7e-58 282458011241 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458011242 Signal peptide predicted for SAR2505 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.571 between residues 30 and 31; signal peptide 282458011243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458011244 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282458011245 putative substrate translocation pore; other site 282458011246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458011247 14 probable transmembrane helices predicted for SAR2505 by TMHMM2.0 at aa 13-35, 45-67, 74-96, 100-122, 134-156, 161-180, 192-214, 224-242, 262-284, 299-321, 328-346, 351-373, 394-416 and 444-466 282458011248 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -134.50, E-value 0.053 282458011249 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 282458011250 catalytic core [active] 282458011251 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 282458011252 Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase, score 346.20, E-value 3.7e-100 282458011253 PS00175 Phosphoglycerate mutase phosphohistidine signature. 282458011254 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 282458011255 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 282458011256 Pfam match to entry PF01545 Cation_efflux, Cation efflux family, score 218.60, E-value 9e-62 282458011257 5 probable transmembrane helices predicted for SAR2507 by TMHMM2.0 at aa 13-35, 39-61, 82-101, 116-135 and 174-196 282458011258 Signal peptide predicted for SAR2508 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.965 between residues 29 and 30; signal peptide 282458011259 B domain; Region: B; pfam02216 282458011260 B domain; Region: B; pfam02216 282458011261 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 282458011262 Pfam match to entry PF02216 B, B domain, score 121.40, E-value 1.7e-32 282458011263 Pfam match to entry PF02216 B, B domain, score 117.10, E-value 3.4e-31 282458011264 Signal peptide predicted for SAR2509 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.976 between residues 29 and 30; signal peptide 282458011265 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 282458011266 Signal peptide predicted for SAR2510 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.984 between residues 29 and 30; signal peptide 282458011267 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 282458011268 Signal peptide predicted for SAR2511 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.825 between residues 26 and 27; signal peptide 282458011269 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 282458011270 Pfam match to entry PF01117 Aerolysin, Aerolysin/Leukocidin family toxin, score -75.60, E-value 0.0014 282458011271 4 probable transmembrane helices predicted for SAR2512 by TMHMM2.0 at aa 9-31, 53-75, 82-104 and 124-146 282458011272 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 282458011273 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 282458011274 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 282458011275 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282458011276 catalytic residue [active] 282458011277 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class-I, score 13.20, E-value 1.5e-05 282458011278 biotin synthase; Validated; Region: PRK06256 282458011279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282458011280 FeS/SAM binding site; other site 282458011281 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 282458011282 Pfam match to entry PF01792 Biotin_synth, Biotin synthase, score 479.90, E-value 2.1e-140 282458011283 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 282458011284 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 282458011285 inhibitor-cofactor binding pocket; inhibition site 282458011286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458011287 catalytic residue [active] 282458011288 Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III, score 466.90, E-value 8.5e-140 282458011289 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 282458011290 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 282458011291 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 282458011292 Signal peptide predicted for SAR2518 by SignalP 2.0 HMM (Signal peptide probabilty 0.657) with cleavage site probability 0.202 between residues 39 and 40; signal peptide 282458011293 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 282458011294 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 282458011295 Walker A/P-loop; other site 282458011296 ATP binding site [chemical binding]; other site 282458011297 Q-loop/lid; other site 282458011298 ABC transporter signature motif; other site 282458011299 Walker B; other site 282458011300 D-loop; other site 282458011301 H-loop/switch region; other site 282458011302 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 208.50, E-value 1e-58 282458011303 PS00211 ABC transporters family signature. 282458011304 PS00017 ATP/GTP-binding site motif A (P-loop). 282458011305 Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region., score 14.40, E-value 0.0012 282458011306 5 probable transmembrane helices predicted for SAR2518 by TMHMM2.0 at aa 21-43, 58-80, 140-157, 161-179 and 242-264 282458011307 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 282458011308 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 282458011309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282458011310 Walker A/P-loop; other site 282458011311 ATP binding site [chemical binding]; other site 282458011312 Q-loop/lid; other site 282458011313 ABC transporter signature motif; other site 282458011314 Walker B; other site 282458011315 D-loop; other site 282458011316 H-loop/switch region; other site 282458011317 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 202.50, E-value 6.6e-57 282458011318 PS00211 ABC transporters family signature. 282458011319 PS00017 ATP/GTP-binding site motif A (P-loop). 282458011320 Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region., score 83.30, E-value 4.8e-21 282458011321 4 probable transmembrane helices predicted for SAR2519 by TMHMM2.0 at aa 29-51, 58-80, 144-166 and 257-279 282458011322 Predicted membrane protein [Function unknown]; Region: COG2246 282458011323 GtrA-like protein; Region: GtrA; pfam04138 282458011324 4 probable transmembrane helices predicted for SAR2521 by TMHMM2.0 at aa 13-35, 40-62, 75-97 and 102-124 282458011325 glycerate kinase; Region: TIGR00045 282458011326 Pfam match to entry PF02595 DUF168, Uncharacterized BCR, COG1929, score 547.40, E-value 9.8e-161 282458011327 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 282458011328 1 probable transmembrane helix predicted for SAR2523 by TMHMM2.0 at aa 70-92 282458011329 Signal peptide predicted for SAR2524 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.603 between residues 42 and 43; signal peptide 282458011330 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 282458011331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458011332 putative substrate translocation pore; other site 282458011333 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -62.40, E-value 0.00015 282458011334 12 probable transmembrane helices predicted for SAR2524 by TMHMM2.0 at aa 13-35, 50-72, 81-100, 105-127, 139-161, 165-187, 217-239, 254-276, 283-305, 309-331, 343-365 and 375-394 282458011335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 282458011336 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 282458011337 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 282458011338 putative phosphoesterase; Region: acc_ester; TIGR03729 282458011339 Signal peptide predicted for SAR2528 by SignalP 2.0 HMM (Signal peptide probabilty 0.914) with cleavage site probability 0.476 between residues 37 and 38; signal peptide 282458011340 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 282458011341 Spore germination protein; Region: Spore_permease; cl17796 282458011342 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score 539.20, E-value 2.9e-158 282458011343 12 probable transmembrane helices predicted for SAR2528 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 122-144, 149-171, 191-213, 234-256, 271-293, 328-350, 360-382, 403-420 and 425-442 282458011344 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 282458011345 Pfam match to entry PF00999 Na_H_Exchanger, Sodium/hydrogen exchanger family, score 197.90, E-value 1.6e-55 282458011346 12 probable transmembrane helices predicted for SAR2529 by TMHMM2.0 at aa 4-21, 28-45, 55-72, 84-106, 110-132, 152-174, 184-206, 230-252, 280-302, 309-331, 366-388 and 401-423 282458011347 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 282458011348 11 probable transmembrane helices predicted for SAR2530 by TMHMM2.0 at aa 58-80, 106-128, 138-160, 172-194, 209-231, 252-274, 302-324, 345-367, 372-394, 407-426 and 430-447 282458011349 PS00589 PTS HPR component serine phosphorylation site signature. 282458011350 PS00012 Phosphopantetheine attachment site. 282458011351 Signal peptide predicted for SAR2531 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.816 between residues 29 and 30; signal peptide 282458011352 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 282458011353 Beta-lactamase; Region: Beta-lactamase; pfam00144 282458011354 4 probable transmembrane helices predicted for SAR2531 by TMHMM2.0 at aa 7-26, 389-408, 429-451 and 471-493 282458011355 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 282458011356 extended (e) SDRs; Region: SDR_e; cd08946 282458011357 NAD(P) binding site [chemical binding]; other site 282458011358 active site 282458011359 substrate binding site [chemical binding]; other site 282458011360 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 282458011361 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 282458011362 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 282458011363 Pfam match to entry PF02558 ApbA, Ketopantoate reductase PanE/ApbA, score 101.90, E-value 1.2e-26 282458011364 Signal peptide predicted for SAR2534 by SignalP 2.0 HMM (Signal peptide probabilty 0.910) with cleavage site probability 0.436 between residues 43 and 44; signal peptide 282458011365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458011366 putative substrate translocation pore; other site 282458011367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458011368 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -81.80, E-value 0.00072 282458011369 14 probable transmembrane helices predicted for SAR2534 by TMHMM2.0 at aa 13-31, 46-68, 81-103, 108-130, 137-159, 163-185, 206-224, 229-251, 271-293, 308-326, 339-358, 362-381, 411-433 and 437-459 282458011370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458011371 dimer interface [polypeptide binding]; other site 282458011372 conserved gate region; other site 282458011373 ABC-ATPase subunit interface; other site 282458011374 5 probable transmembrane helices predicted for SAR2535 by TMHMM2.0 at aa 27-49, 56-78, 88-110, 138-160 and 185-207 282458011375 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 47.60, E-value 2.8e-10 282458011376 Signal peptide predicted for SAR2536 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.339 between residues 28 and 29; signal peptide 282458011377 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 282458011378 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 282458011379 1 probable transmembrane helix predicted for SAR2536 by TMHMM2.0 at aa 7-26 282458011380 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458011381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458011382 dimer interface [polypeptide binding]; other site 282458011383 conserved gate region; other site 282458011384 putative PBP binding loops; other site 282458011385 ABC-ATPase subunit interface; other site 282458011386 5 probable transmembrane helices predicted for SAR2537 by TMHMM2.0 at aa 20-42, 49-71, 81-100, 144-166 and 176-198 282458011387 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 57.30, E-value 3.2e-13 282458011388 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282458011389 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 282458011390 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 282458011391 Walker A/P-loop; other site 282458011392 ATP binding site [chemical binding]; other site 282458011393 Q-loop/lid; other site 282458011394 ABC transporter signature motif; other site 282458011395 Walker B; other site 282458011396 D-loop; other site 282458011397 H-loop/switch region; other site 282458011398 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 282458011399 Pfam match to entry PF00571 CBS, CBS domain, score 34.00, E-value 3.5e-06 282458011400 Pfam match to entry PF00571 CBS, CBS domain, score 28.60, E-value 0.00014 282458011401 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 226.70, E-value 3.3e-64 282458011402 PS00211 ABC transporters family signature. 282458011403 PS00017 ATP/GTP-binding site motif A (P-loop). 282458011404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 282458011405 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 282458011406 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 282458011407 Signal peptide predicted for SAR2540 by SignalP 2.0 HMM (Signal peptide probabilty 0.891) with cleavage site probability 0.285 between residues 36 and 37; signal peptide 282458011408 amino acid transporter; Region: 2A0306; TIGR00909 282458011409 14 probable transmembrane helices predicted for SAR2540 by TMHMM2.0 at aa 12-34, 44-66, 87-109, 134-156, 163-185, 200-222, 242-264, 298-320, 345-367, 372-394, 407-429, 433-450, 463-484 and 499-521 282458011410 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score -138.10, E-value 1.7e-07 282458011411 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 282458011412 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 282458011413 substrate binding pocket [chemical binding]; other site 282458011414 catalytic triad [active] 282458011415 Pfam match to entry PF00135 COesterase, Carboxylesterase, score 187.40, E-value 7.5e-54 282458011416 PS00941 Carboxylesterases type-B signature 2. 282458011417 PS00122 Carboxylesterases type-B serine active site. 282458011418 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 282458011419 Signal peptide predicted for SAR2542 by SignalP 2.0 HMM (Signal peptide probabilty 0.710) with cleavage site probability 0.318 between residues 36 and 37; signal peptide 282458011420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458011421 putative substrate translocation pore; other site 282458011422 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -72.80, E-value 0.00035 282458011423 10 probable transmembrane helices predicted for SAR2542 by TMHMM2.0 at aa 7-29, 39-60, 73-95, 100-122, 129-151, 155-177, 214-236, 246-268, 281-303 and 364-383 282458011424 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 282458011425 Signal peptide predicted for SAR2543 by SignalP 2.0 HMM (Signal peptide probabilty 0.770) with cleavage site probability 0.493 between residues 22 and 23; signal peptide 282458011426 6 probable transmembrane helices predicted for SAR2543 by TMHMM2.0 at aa 2-21, 31-53, 60-77, 87-109, 189-211 and 216-238 282458011427 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 282458011428 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 282458011429 Walker A/P-loop; other site 282458011430 ATP binding site [chemical binding]; other site 282458011431 Q-loop/lid; other site 282458011432 ABC transporter signature motif; other site 282458011433 Walker B; other site 282458011434 D-loop; other site 282458011435 H-loop/switch region; other site 282458011436 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 177.90, E-value 1.7e-49 282458011437 PS00211 ABC transporters family signature. 282458011438 PS00017 ATP/GTP-binding site motif A (P-loop). 282458011439 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 282458011440 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 282458011441 oligomer interface [polypeptide binding]; other site 282458011442 active site 282458011443 metal binding site [ion binding]; metal-binding site 282458011444 Signal peptide predicted for SAR2546 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.587 between residues 22 and 23; signal peptide 282458011445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 282458011446 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458011447 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 282458011448 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 282458011449 active site 282458011450 FMN binding site [chemical binding]; other site 282458011451 substrate binding site [chemical binding]; other site 282458011452 3Fe-4S cluster binding site [ion binding]; other site 282458011453 Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase, score 393.70, E-value 1.9e-114 282458011454 1 probable transmembrane helix predicted for SAR2547 by TMHMM2.0 at aa 9-31 282458011455 6 probable transmembrane helices predicted for SAR2548 by TMHMM2.0 at aa 27-49, 59-81, 106-128, 148-170, 182-204 and 231-248 282458011456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458011457 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282458011458 putative substrate translocation pore; other site 282458011459 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -132.30, E-value 0.044 282458011460 12 probable transmembrane helices predicted for SAR2549 by TMHMM2.0 at aa 7-29, 39-61, 74-93, 98-120, 132-154, 159-178, 214-236, 241-263, 283-305, 309-331, 338-360 and 364-386 282458011461 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 282458011462 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282458011463 Walker A/P-loop; other site 282458011464 ATP binding site [chemical binding]; other site 282458011465 Q-loop/lid; other site 282458011466 ABC transporter signature motif; other site 282458011467 Walker B; other site 282458011468 D-loop; other site 282458011469 H-loop/switch region; other site 282458011470 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 199.00, E-value 7.4e-56 282458011471 PS00211 ABC transporters family signature. 282458011472 PS00017 ATP/GTP-binding site motif A (P-loop). 282458011473 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282458011474 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 282458011475 Walker A/P-loop; other site 282458011476 ATP binding site [chemical binding]; other site 282458011477 Q-loop/lid; other site 282458011478 ABC transporter signature motif; other site 282458011479 Walker B; other site 282458011480 D-loop; other site 282458011481 H-loop/switch region; other site 282458011482 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 282458011483 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 178.40, E-value 1.1e-49 282458011484 PS00211 ABC transporters family signature. 282458011485 PS00017 ATP/GTP-binding site motif A (P-loop). 282458011486 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 282458011487 Signal peptide predicted for SAR2552 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.739 between residues 36 and 37; signal peptide 282458011488 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 282458011489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458011490 dimer interface [polypeptide binding]; other site 282458011491 conserved gate region; other site 282458011492 putative PBP binding loops; other site 282458011493 ABC-ATPase subunit interface; other site 282458011494 5 probable transmembrane helices predicted for SAR2552 by TMHMM2.0 at aa 13-35, 79-101, 122-144, 194-216 and 236-258 282458011495 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 29.20, E-value 9.5e-05 282458011496 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 282458011497 Signal peptide predicted for SAR2553 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.951 between residues 41 and 42; signal peptide 282458011498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282458011499 dimer interface [polypeptide binding]; other site 282458011500 conserved gate region; other site 282458011501 putative PBP binding loops; other site 282458011502 ABC-ATPase subunit interface; other site 282458011503 6 probable transmembrane helices predicted for SAR2553 by TMHMM2.0 at aa 9-31, 107-126, 139-161, 176-193, 234-256 and 276-298 282458011504 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 282458011505 Signal peptide predicted for SAR2554 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.567 between residues 28 and 29; signal peptide 282458011506 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 282458011507 substrate binding site [chemical binding]; other site 282458011508 Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 246.00, E-value 5.1e-70 282458011509 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 282458011510 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458011511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 282458011512 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 282458011513 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 282458011514 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 282458011515 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 282458011516 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 282458011517 short chain dehydrogenase; Validated; Region: PRK08589 282458011518 Signal peptide predicted for SAR2559 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.649 between residues 27 and 28; signal peptide 282458011519 classical (c) SDRs; Region: SDR_c; cd05233 282458011520 NAD(P) binding site [chemical binding]; other site 282458011521 active site 282458011522 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 271.90, E-value 8.5e-78 282458011523 PS00061 Short-chain dehydrogenases/reductases family signature. 282458011524 AbgT putative transporter family; Region: ABG_transport; cl17431 282458011525 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 282458011526 12 probable transmembrane helices predicted for SAR2560 by TMHMM2.0 at aa 32-54, 85-104, 124-157, 164-186, 215-237, 269-291, 306-328, 341-363, 388-407, 414-433, 443-462 and 482-504 282458011527 Uncharacterized conserved protein [Function unknown]; Region: COG2128 282458011528 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 282458011529 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 282458011530 1 probable transmembrane helix predicted for SAR2562 by TMHMM2.0 at aa 5-27 282458011531 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 282458011532 1 probable transmembrane helix predicted for SAR2563 by TMHMM2.0 at aa 7-25 282458011533 No significant database matches. Contains a frameshift after codon 28; membrane protein (pseudogene) 282458011534 1 probable transmembrane helix predicted for SAR2564 by TMHMM2.0 at aa 6-25 282458011535 Signal peptide predicted for SAR2564 by SignalP 2.0 HMM (Signal peptide probabilty 0.902) with cleavage site probability 0.597 between residues 22 and 23 282458011536 Signal peptide predicted for SAR2565 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.681 between residues 21 and 22; signal peptide 282458011537 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 282458011538 1 probable transmembrane helix predicted for SAR2565 by TMHMM2.0 at aa 6-25 282458011539 Signal peptide predicted for SAR2566 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.623 between residues 29 and 30; signal peptide 282458011540 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 282458011541 1 probable transmembrane helix predicted for SAR2566 by TMHMM2.0 at aa 5-27 282458011542 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 282458011543 classical (c) SDRs; Region: SDR_c; cd05233 282458011544 NAD(P) binding site [chemical binding]; other site 282458011545 active site 282458011546 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 225.30, E-value 9.2e-64 282458011547 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 282458011548 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282458011549 Signal peptide predicted for SAR2570 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.266 between residues 31 and 32; signal peptide 282458011550 1 probable transmembrane helix predicted for SAR2570 by TMHMM2.0 at aa 7-26 282458011551 No significant database matches. Similar to SAR2570, 70% identity in 180 aa, SAR2573, 64% identity in 165 aa, SAR0106, 61% identity in 138 aa, and to SAR0444, 60% identity in 137 aa. Contains a frameshift after codon 132. Frameshift occurs at a poly A heptamer; exported protein (pseudogene) 282458011552 Signal peptide predicted for SAR2571 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.476 between residues 31 and 32 282458011553 1 probable transmembrane helix predicted for SAR2571 by TMHMM2.0 at aa 7-26 282458011554 Signal peptide predicted for SAR2573 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.795 between residues 31 and 32; signal peptide 282458011555 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282458011556 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458011557 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 282458011558 PLD-like domain; Region: PLDc_2; pfam13091 282458011559 putative homodimer interface [polypeptide binding]; other site 282458011560 putative active site [active] 282458011561 catalytic site [active] 282458011562 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 282458011563 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282458011564 ATP binding site [chemical binding]; other site 282458011565 putative Mg++ binding site [ion binding]; other site 282458011566 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282458011567 nucleotide binding region [chemical binding]; other site 282458011568 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 282458011569 ATP-binding site [chemical binding]; other site 282458011570 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 282458011571 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 69.30, E-value 8.1e-17 282458011572 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 282458011573 active site 282458011574 8-oxo-dGMP binding site [chemical binding]; other site 282458011575 nudix motif; other site 282458011576 metal binding site [ion binding]; metal-binding site 282458011577 Pfam match to entry PF00293 NUDIX, MutT-like domain, score 11.80, E-value 0.024 282458011578 PS00893 mutT domain signature. 282458011579 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 282458011580 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 282458011581 active site 282458011582 substrate binding site [chemical binding]; other site 282458011583 metal binding site [ion binding]; metal-binding site 282458011584 Pfam match to entry PF02878 PGM_PMM_I, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I, score 61.40, E-value 1.9e-14 282458011585 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 282458011586 Pfam match to entry PF02879 PGM_PMM_II, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II, score 22.40, E-value 4.3e-05 282458011587 Pfam match to entry PF02880 PGM_PMM_III, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III, score -6.40, E-value 0.31 282458011588 Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase, C-terminal domain, score 16.60, E-value 0.0022 282458011589 Signal peptide predicted for SAR2577 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.643 between residues 28 and 29; signal peptide 282458011590 1 probable transmembrane helix predicted for SAR2577 by TMHMM2.0 at aa 7-29 282458011591 3 probable transmembrane helices predicted for SAR2578 by TMHMM2.0 at aa 5-24, 47-69 and 74-96 282458011592 Signal peptide predicted for SAR2579 by SignalP 2.0 HMM (Signal peptide probabilty 0.787) with cleavage site probability 0.730 between residues 24 and 25; signal peptide 282458011593 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 282458011594 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 282458011595 active site 282458011596 tetramer interface; other site 282458011597 Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase, score 106.20, E-value 6.2e-28 282458011598 Signal peptide predicted for SAR2580 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.554 between residues 37 and 38; signal peptide 282458011599 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282458011600 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 282458011601 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 282458011602 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 46.20, E-value 7.3e-10 282458011603 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282458011604 Pfam match to entry PF02986 Fn_bind, , score 15.70, E-value 0.063 282458011605 GntP family permease; Region: GntP_permease; pfam02447 282458011606 fructuronate transporter; Provisional; Region: PRK10034; cl15264 282458011607 Pfam match to entry PF02447 GntP_permease, GntP family permease, score 833.20, E-value 9.1e-247 282458011608 12 probable transmembrane helices predicted for SAR2582 by TMHMM2.0 at aa 5-24, 29-51, 63-85, 105-127, 140-159, 179-201, 232-254, 269-288, 309-331, 351-373, 385-407 and 427-449 282458011609 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 282458011610 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 282458011611 N- and C-terminal domain interface [polypeptide binding]; other site 282458011612 active site 282458011613 catalytic site [active] 282458011614 metal binding site [ion binding]; metal-binding site 282458011615 carbohydrate binding site [chemical binding]; other site 282458011616 ATP binding site [chemical binding]; other site 282458011617 Pfam match to entry PF02782 FGGY_C, FGGY family of carbohydrate kinases, C-terminal domain, score 294.90, E-value 1e-84 282458011618 PS00445 FGGY family of carbohydrate kinases signature 2. 282458011619 Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases, N-terminal domain, score 286.60, E-value 3.2e-82 282458011620 Transcriptional regulators [Transcription]; Region: GntR; COG1802 282458011621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 282458011622 DNA-binding site [nucleotide binding]; DNA binding site 282458011623 FCD domain; Region: FCD; pfam07729 282458011624 Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 43.80, E-value 5.6e-12 282458011625 PS00043 Bacterial regulatory proteins, gntR family signature. 282458011626 Predicted helix-turn-helix motif with score 1508 (+4.32 SD) at aa 38-59, sequence LTENQMAKQFNVSRSPIRDAFK 282458011627 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 282458011628 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 282458011629 DNA binding residues [nucleotide binding] 282458011630 2 probable transmembrane helices predicted for SAR2585 by TMHMM2.0 at aa 141-163 and 168-187 282458011631 Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family, score 45.90, E-value 9e-10 282458011632 Predicted helix-turn-helix motif with score 1686 (+4.93 SD) at aa 4-25, sequence YSTGELAKLCNVTTRTIQYYDR 282458011633 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 282458011634 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 282458011635 synthetase active site [active] 282458011636 NTP binding site [chemical binding]; other site 282458011637 metal binding site [ion binding]; metal-binding site 282458011638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 282458011639 Predicted membrane protein [Function unknown]; Region: COG1289 282458011640 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 282458011641 9 probable transmembrane helices predicted for SAR2588 by TMHMM2.0 at aa 9-31, 46-68, 75-97, 112-134, 305-327, 332-351, 364-386, 401-420 and 427-449 282458011642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282458011643 D-galactonate transporter; Region: 2A0114; TIGR00893 282458011644 putative substrate translocation pore; other site 282458011645 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -108.30, E-value 0.0062 282458011646 11 probable transmembrane helices predicted for SAR2589 by TMHMM2.0 at aa 7-25, 48-70, 83-105, 140-162, 167-186, 227-249, 270-292, 297-319, 326-348, 363-385 and 392-409 282458011647 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 282458011648 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 282458011649 5 probable transmembrane helices predicted for SAR2590 by TMHMM2.0 at aa 13-35, 50-72, 108-127, 137-159 and 179-196 282458011650 Pfam match to entry PF00597 DedA, DedA family, score 29.30, E-value 8.6e-05 282458011651 Signal peptide predicted for SAR2591 by SignalP 2.0 HMM (Signal peptide probabilty 0.933) with cleavage site probability 0.430 between residues 28 and 29; signal peptide 282458011652 Lysine efflux permease [General function prediction only]; Region: COG1279 282458011653 6 probable transmembrane helices predicted for SAR2591 by TMHMM2.0 at aa 5-27, 40-62, 72-91, 112-134, 144-165 and 178-197 282458011654 Pfam match to entry PF01810 LysE, LysE type translocator, score 65.50, E-value 1.2e-15 282458011655 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 282458011656 Fatty acid desaturase; Region: FA_desaturase; pfam00487 282458011657 putative di-iron ligands [ion binding]; other site 282458011658 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 282458011659 Pfam match to entry PF00487 FA_desaturase, Fatty acid desaturase, score -147.30, E-value 4 282458011660 4 probable transmembrane helices predicted for SAR2592 by TMHMM2.0 at aa 30-64, 87-109, 146-168 and 189-211 282458011661 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 282458011662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 282458011663 DNA-binding site [nucleotide binding]; DNA binding site 282458011664 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 282458011665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458011666 homodimer interface [polypeptide binding]; other site 282458011667 catalytic residue [active] 282458011668 Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 49.80, E-value 7.7e-14 282458011669 Predicted helix-turn-helix motif with score 1791 (+5.29 SD) at aa 29-50, sequence YSQRKLAKYYNVNKSTVIQALD 282458011670 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class-I, score 10.80, E-value 2e-05 282458011671 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 282458011672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282458011673 Walker A/P-loop; other site 282458011674 ATP binding site [chemical binding]; other site 282458011675 Q-loop/lid; other site 282458011676 ABC transporter signature motif; other site 282458011677 Walker B; other site 282458011678 D-loop; other site 282458011679 H-loop/switch region; other site 282458011680 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 157.00, E-value 3.2e-43 282458011681 PS00017 ATP/GTP-binding site motif A (P-loop). 282458011682 PS00211 ABC transporters family signature. 282458011683 Signal peptide predicted for SAR2595 by SignalP 2.0 HMM (Signal peptide probabilty 0.880) with cleavage site probability 0.612 between residues 33 and 34; signal peptide 282458011684 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 282458011685 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 282458011686 6 probable transmembrane helices predicted for SAR2595 by TMHMM2.0 at aa 17-36, 56-78, 98-120, 144-166, 173-195 and 229-251 282458011687 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 282458011688 Signal peptide predicted for SAR2597 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.379 between residues 26 and 27; signal peptide 282458011689 Uncharacterized membrane protein [Function unknown]; Region: COG3949 282458011690 10 probable transmembrane helices predicted for SAR2597 by TMHMM2.0 at aa 7-26, 36-58, 78-100, 115-134, 139-161, 187-209, 221-243, 267-289, 302-324 and 328-345 282458011691 Predicted esterase [General function prediction only]; Region: COG0400 282458011692 putative hydrolase; Provisional; Region: PRK11460 282458011693 Pfam match to entry PF02230 abhydrolase_2, Phospholipase/Carboxylesterase, score -13.50, E-value 3.6e-06 282458011694 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 282458011695 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 282458011696 Zn binding site [ion binding]; other site 282458011697 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 282458011698 Zn binding site [ion binding]; other site 282458011699 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 28.90, E-value 4.6e-07 282458011700 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 282458011701 MarR family; Region: MarR; pfam01047 282458011702 Pfam match to entry PF01047 MarR, MarR family, score 101.60, E-value 1.5e-26 282458011703 Predicted acetyltransferase [General function prediction only]; Region: COG2388 282458011704 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 16.20, E-value 0.18 282458011705 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 282458011706 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 282458011707 putative metal binding site [ion binding]; other site 282458011708 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 282458011709 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 56.70, E-value 4.2e-15 282458011710 PS00082 Extradiol ring-cleavage dioxygenases signature. 282458011711 Similar to Vibrio fischeri major NAD(P)H-flavin oxidoreductase SW:FRA1_VIBFI (P46072) (217 aa) fasta scores: E(): 3.8e-15, 31.81% id in 220 aa, and to Bacillus subtilis NAD(P)H-flavin oxidoreductase YfkO SW:YFKO_BACSU (O34475) (221 aa) fasta scores: E(): 1.3e-46, 54.5% id in 222 aa. Contains a nonsense mutation (ochre) after codon 92;nitroreductase (pseudogene) 282458011712 Pfam match to entry PF00881 Nitroreductase, Nitroreductase, score 10.30, E-value 0.00064 282458011713 D-lactate dehydrogenase; Provisional; Region: PRK12480 282458011714 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 282458011715 homodimer interface [polypeptide binding]; other site 282458011716 ligand binding site [chemical binding]; other site 282458011717 NAD binding site [chemical binding]; other site 282458011718 catalytic site [active] 282458011719 Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 49.30, E-value 8.6e-11 282458011720 Pfam match to entry PF02826 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 241.50, E-value 1.2e-68 282458011721 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 282458011722 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 282458011723 Insertion sequence IS1272 282458011724 Similar to N-terminal region of Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 5.8e-52, 92.908% id in 141 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 2.5e-26, 50.355% id in 141 aa. CDS contains a frameshift (after codon 58) and is truncated, probable gene remnant; transposase (fragment) 282458011725 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 282458011726 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282458011727 active site 282458011728 motif I; other site 282458011729 motif II; other site 282458011730 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 9.70, E-value 0.033 282458011731 PS01229 Hypothetical cof family signature 2. 282458011732 Signal peptide predicted for SAR2608 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.743 between residues 25 and 26; signal peptide 282458011733 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 282458011734 active site 282458011735 catalytic site [active] 282458011736 1 probable transmembrane helix predicted for SAR2608 by TMHMM2.0 at aa 7-24 282458011737 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 282458011738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458011739 Coenzyme A binding pocket [chemical binding]; other site 282458011740 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 80.90, E-value 2.7e-20 282458011741 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 282458011742 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 282458011743 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 282458011744 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 282458011745 Signal peptide predicted for SAR2612 by SignalP 2.0 HMM (Signal peptide probabilty 0.731) with cleavage site probability 0.408 between residues 23 and 24; signal peptide 282458011746 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 282458011747 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 282458011748 9 probable transmembrane helices predicted for SAR2612 by TMHMM2.0 at aa 4-21, 34-56, 76-98, 103-120, 130-152, 173-195, 205-224, 256-278 and 303-325 282458011749 1 probable transmembrane helix predicted for SAR2613 by TMHMM2.0 at aa 13-35 282458011750 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 282458011751 EamA-like transporter family; Region: EamA; pfam00892 282458011752 EamA-like transporter family; Region: EamA; pfam00892 282458011753 10 probable transmembrane helices predicted for SAR2614 by TMHMM2.0 at aa 7-29, 39-58, 79-101, 106-125, 132-154, 159-181, 186-208, 223-245, 258-277 and 282-299 282458011754 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6, score 57.50, E-value 2.9e-13 282458011755 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6, score 74.80, E-value 1.9e-18 282458011756 Signal peptide predicted for SAR2615 by SignalP 2.0 HMM (Signal peptide probabilty 0.815) with cleavage site probability 0.555 between residues 18 and 19; signal peptide 282458011757 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 282458011758 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 282458011759 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 282458011760 catalytic residues [active] 282458011761 PS00190 Cytochrome c family heme-binding site signature. 282458011762 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 282458011763 active site 282458011764 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282458011765 Signal peptide predicted for SAR2618 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.446 between residues 35 and 36; signal peptide 282458011766 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 282458011767 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282458011768 active site turn [active] 282458011769 phosphorylation site [posttranslational modification] 282458011770 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 282458011771 HPr interaction site; other site 282458011772 glycerol kinase (GK) interaction site [polypeptide binding]; other site 282458011773 active site 282458011774 phosphorylation site [posttranslational modification] 282458011775 Pfam match to entry PF00358 PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1, score 208.00, E-value 1.5e-58 282458011776 PS00371 PTS EIIA domains phosphorylation site signature 1. 282458011777 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 64.70, E-value 3.7e-17 282458011778 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282458011779 9 probable transmembrane helices predicted for SAR2618 by TMHMM2.0 at aa 12-34, 78-100, 138-160, 180-202, 223-245, 283-305, 338-360, 364-386 and 393-415 282458011780 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 553.10, E-value 1.8e-162 282458011781 pyruvate oxidase; Provisional; Region: PRK08611 282458011782 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 282458011783 PYR/PP interface [polypeptide binding]; other site 282458011784 tetramer interface [polypeptide binding]; other site 282458011785 dimer interface [polypeptide binding]; other site 282458011786 TPP binding site [chemical binding]; other site 282458011787 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 282458011788 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 282458011789 TPP-binding site [chemical binding]; other site 282458011790 Pfam match to entry PF02775 TPP_enzymes_C, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 192.30, E-value 7.4e-54 282458011791 PS00187 Thiamine pyrophosphate enzymes signature. 282458011792 Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzyme, central domain, score 131.10, E-value 2e-35 282458011793 Pfam match to entry PF02776 TPP_enzymes_N, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 151.30, E-value 1.6e-41 282458011794 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 282458011795 6 probable transmembrane helices predicted for SAR2620 by TMHMM2.0 at aa 4-21, 30-52, 62-79, 90-112, 149-171 and 204-226 282458011796 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 282458011797 4 probable transmembrane helices predicted for SAR2621 by TMHMM2.0 at aa 7-25, 30-49, 62-82 and 92-114 282458011798 Transcriptional regulator [Transcription]; Region: LysR; COG0583 282458011799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 282458011800 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 282458011801 putative dimerization interface [polypeptide binding]; other site 282458011802 Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 142.20, E-value 9e-39 282458011803 PS00044 Bacterial regulatory proteins, lysR family signature. 282458011804 Predicted helix-turn-helix motif with score 1179 (+3.20 SD) at aa 19-40, sequence GGMTNASKSLYIAQPTISKAIK 282458011805 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 282458011806 Surface antigen [General function prediction only]; Region: COG3942 282458011807 Signal peptide predicted for SAR2624 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.858 between residues 35 and 36; signal peptide 282458011808 CHAP domain; Region: CHAP; pfam05257 282458011809 1 probable transmembrane helix predicted for SAR2624 by TMHMM2.0 at aa 7-24 282458011810 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 282458011811 homodimer interface [polypeptide binding]; other site 282458011812 catalytic residues [active] 282458011813 NAD binding site [chemical binding]; other site 282458011814 substrate binding pocket [chemical binding]; other site 282458011815 flexible flap; other site 282458011816 PS01192 Hydroxymethylglutaryl-coenzyme A reductases signature 3. 282458011817 PS00066 Hydroxymethylglutaryl-coenzyme A reductases signature 1. 282458011818 Pfam match to entry PF00368 HMG-CoA_red, Hydroxymethylglutaryl-coenzyme A reductase, score 39.20, E-value 2.5e-11 282458011819 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 282458011820 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 282458011821 dimer interface [polypeptide binding]; other site 282458011822 active site 282458011823 Pfam match to entry PF01154 HMG_CoA_synt, Hydroxymethylglutaryl-coenzyme A synthase, score -67.70, E-value 1.4e-14 282458011824 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 282458011825 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 282458011826 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 282458011827 DNA binding site [nucleotide binding] 282458011828 active site 282458011829 Pfam match to entry PF01035 Methyltransf_1, 6-O-methylguanine DNA methyltransferase, DNA binding domain, score 122.60, E-value 7.6e-33 282458011830 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 282458011831 Pfam match to entry PF02870 Methyltransf_1N, 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain, score 45.90, E-value 9.1e-10 282458011832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458011833 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 282458011834 Walker A motif; other site 282458011835 ATP binding site [chemical binding]; other site 282458011836 Walker B motif; other site 282458011837 arginine finger; other site 282458011838 UvrB/uvrC motif; Region: UVR; pfam02151 282458011839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282458011840 Walker A motif; other site 282458011841 ATP binding site [chemical binding]; other site 282458011842 Walker B motif; other site 282458011843 arginine finger; other site 282458011844 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 282458011845 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA), score 54.00, E-value 3.2e-12 282458011846 PS00017 ATP/GTP-binding site motif A (P-loop). 282458011847 Pfam match to entry PF02151 UVR, UvrB/uvrC motif, score 19.00, E-value 0.024 282458011848 PS00017 ATP/GTP-binding site motif A (P-loop). 282458011849 Virus attachment protein p12 family; Region: P12; pfam12669 282458011850 1 probable transmembrane helix predicted for SAR2629 by TMHMM2.0 at aa 4-22 282458011851 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 282458011852 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 282458011853 G1 box; other site 282458011854 GTP/Mg2+ binding site [chemical binding]; other site 282458011855 Switch I region; other site 282458011856 G2 box; other site 282458011857 G3 box; other site 282458011858 Switch II region; other site 282458011859 G4 box; other site 282458011860 G5 box; other site 282458011861 Nucleoside recognition; Region: Gate; pfam07670 282458011862 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 282458011863 Nucleoside recognition; Region: Gate; pfam07670 282458011864 Pfam match to entry PF02421 FeoB, Ferrous iron transport protein B, score 879.90, E-value 8e-261 282458011865 10 probable transmembrane helices predicted for SAR2630 by TMHMM2.0 at aa 280-302, 342-364, 385-407, 422-444, 451-473, 514-536, 543-565, 580-599, 606-628 and 638-660 282458011866 PS00017 ATP/GTP-binding site motif A (P-loop). 282458011867 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 282458011868 Signal peptide predicted for SAR2632 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.528 between residues 37 and 38; signal peptide 282458011869 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 282458011870 Protein export membrane protein; Region: SecD_SecF; cl14618 282458011871 12 probable transmembrane helices predicted for SAR2632 by TMHMM2.0 at aa 17-39, 180-202, 204-226, 230-252, 276-298, 308-330, 354-376, 522-544, 549-568, 578-600, 633-652 and 662-684 282458011872 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282458011873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 282458011874 Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 22.20, E-value 0.00055 282458011875 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 282458011876 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 282458011877 Glutamate binding site [chemical binding]; other site 282458011878 homodimer interface [polypeptide binding]; other site 282458011879 NAD binding site [chemical binding]; other site 282458011880 catalytic residues [active] 282458011881 Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase, score 601.40, E-value 5.4e-177 282458011882 PS00070 Aldehyde dehydrogenases cysteine active site. 282458011883 PS00687 Aldehyde dehydrogenases glutamic acid active site. 282458011884 maltose O-acetyltransferase; Provisional; Region: PRK10092 282458011885 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 282458011886 active site 282458011887 substrate binding site [chemical binding]; other site 282458011888 trimer interface [polypeptide binding]; other site 282458011889 CoA binding site [chemical binding]; other site 282458011890 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 16.30, E-value 0.74 282458011891 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 2.00, E-value 4.3e+02 282458011892 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 13.60, E-value 4.9 282458011893 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), score 8.60, E-value 63 282458011894 Signal peptide predicted for SAR2636 by SignalP 2.0 HMM (Signal peptide probabilty 0.673) with cleavage site probability 0.478 between residues 23 and 24; signal peptide 282458011895 1 probable transmembrane helix predicted for SAR2636 by TMHMM2.0 at aa 4-21 282458011896 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 282458011897 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 282458011898 metal-binding site [ion binding] 282458011899 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 282458011900 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 282458011901 metal-binding site [ion binding] 282458011902 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 282458011903 Soluble P-type ATPase [General function prediction only]; Region: COG4087 282458011904 Pfam match to entry PF00403 HMA, Heavy-metal-associated domain, score 88.70, E-value 1.1e-22 282458011905 PS01047 Heavy-metal-associated domain. 282458011906 Pfam match to entry PF00403 HMA, Heavy-metal-associated domain, score 103.30, E-value 4.7e-27 282458011907 PS01047 Heavy-metal-associated domain. 282458011908 8 probable transmembrane helices predicted for SAR2637 by TMHMM2.0 at aa 158-180, 190-212, 219-241, 256-274, 407-429, 444-466, 748-767 and 771-790 282458011909 Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 ATPase, score 354.00, E-value 2e-106 282458011910 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 131.70, E-value 1.4e-35 282458011911 PS00154 E1-E2 ATPases phosphorylation site. 282458011912 Repeat region, TATGCAGTTGGAGCGAAGATCCAACTGTAAACC x5 282458011913 Repeat region. Direct perfect repeat (acttattatttataataattagtggctcttatgcagttggagcgaagatccaactgt a aaccatagtgt) x6 282458011914 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 282458011915 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 282458011916 metal-binding site [ion binding] 282458011917 Pfam match to entry PF00403 HMA, Heavy-metal-associated domain, score 75.80, E-value 9.3e-19 282458011918 PS01047 Heavy-metal-associated domain. 282458011919 D-lactate dehydrogenase; Validated; Region: PRK08605 282458011920 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 282458011921 homodimer interface [polypeptide binding]; other site 282458011922 ligand binding site [chemical binding]; other site 282458011923 NAD binding site [chemical binding]; other site 282458011924 catalytic site [active] 282458011925 Pfam match to entry PF02826 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 226.20, E-value 4.8e-64 282458011926 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 282458011927 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 282458011928 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 282458011929 Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 60.50, E-value 3.6e-14 282458011930 transaminase; Reviewed; Region: PRK08068 282458011931 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 282458011932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458011933 homodimer interface [polypeptide binding]; other site 282458011934 catalytic residue [active] 282458011935 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class-I, score 81.20, E-value 2.1e-20 282458011936 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 282458011937 Signal peptide predicted for SAR2642 by SignalP 2.0 HMM (Signal peptide probabilty 0.835) with cleavage site probability 0.387 between residues 23 and 24; signal peptide 282458011938 phytoene desaturase; Region: crtI_fam; TIGR02734 282458011939 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 282458011940 Pfam match to entry PF02032 Phytoene_dh, Phytoene dehydrogenase related enzyme, score 409.80, E-value 2.6e-119 282458011941 Previously sequenced as Staphylococcus aureus squalene desaturase CrtM TR:O07854 (EMBL:X73889) (255 aa) fasta scores: E(): 3.9e-93, 97.22% id in 252 aa. Similar to Thermus aquaticus phytoene synthase CrtB SW:CRTB_THETH (P37270) (289 aa) fasta scores: E(): 1.3e-16, 28.46% id in 274 aa. Contains a nonsense mutation (ochre) after codon 94. CDS contains an extended C-terminus in comparison to the previously sequenced protein;squalene desaturase (pseudogene) 282458011942 Pfam match to entry PF00494 SQS_PSY, Squalene/phytoene synthase, score 52.50, E-value 1.3e-13 282458011943 PS01044 Squalene and phytoene synthases signature 1. 282458011944 Pfam match to entry PF00494 SQS_PSY, Squalene/phytoene synthase, score 36.80, E-value 3e-09 282458011945 Signal peptide predicted for SAR2645 by SignalP 2.0 HMM (Signal peptide probabilty 0.911) with cleavage site probability 0.728 between residues 31 and 32; signal peptide 282458011946 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 282458011947 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 282458011948 active site 282458011949 4 probable transmembrane helices predicted for SAR2645 by TMHMM2.0 at aa 4-23, 164-186, 277-299 and 330-352 282458011950 Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferase, score 82.50, E-value 8.8e-21 282458011951 Signal peptide predicted for SAR2646 by SignalP 2.0 HMM (Signal peptide probabilty 0.803) with cleavage site probability 0.321 between residues 24 and 25; signal peptide 282458011952 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 282458011953 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 282458011954 Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237 282458011955 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 282458011956 Pfam match to entry PF02032 Phytoene_dh, Phytoene dehydrogenase related enzyme, score 248.10, E-value 1.2e-70 282458011957 1 probable transmembrane helix predicted for SAR2647 by TMHMM2.0 at aa 126-145 282458011958 Signal peptide predicted for SAR2648 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.987 between residues 26 and 27; signal peptide 282458011959 Surface antigen [General function prediction only]; Region: COG3942 282458011960 CHAP domain; Region: CHAP; pfam05257 282458011961 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 282458011962 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 282458011963 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 282458011964 catalytic triad [active] 282458011965 catalytic triad [active] 282458011966 oxyanion hole [active] 282458011967 11 probable transmembrane helices predicted for SAR2649 by TMHMM2.0 at aa 17-39, 44-66, 87-105, 147-169, 176-198, 213-232, 239-261, 271-293, 313-330, 334-356 and 377-399 282458011968 Pfam match to entry PF01757 DUF33, Domain of unknown function DUF33, score 24.90, E-value 4.5e-06 282458011969 Pfam match to entry PF01757 DUF33, Domain of unknown function DUF33, score 83.00, E-value 1.9e-22 282458011970 Signal peptide predicted for SAR2650 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.910 between residues 29 and 30; signal peptide 282458011971 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 282458011972 N-acetyl-D-glucosamine binding site [chemical binding]; other site 282458011973 catalytic residue [active] 282458011974 Signal peptide predicted for SAR2651 by SignalP 2.0 HMM (Signal peptide probabilty 0.605) with cleavage site probability 0.331 between residues 35 and 36; signal peptide 282458011975 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 282458011976 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 282458011977 10 probable transmembrane helices predicted for SAR2651 by TMHMM2.0 at aa 13-35, 50-72, 79-96, 106-128, 135-157, 172-194, 199-221, 225-247, 259-281 and 309-331 282458011978 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 282458011979 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 282458011980 Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 22.80, E-value 0.00038 282458011981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 282458011982 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 282458011983 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 282458011984 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 10.30, E-value 0.11 282458011985 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 282458011986 NmrA-like family; Region: NmrA; pfam05368 282458011987 NADP binding site [chemical binding]; other site 282458011988 active site 282458011989 regulatory binding site [polypeptide binding]; other site 282458011990 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 282458011991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 282458011992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 282458011993 Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 47.00, E-value 1.6e-10 282458011994 PS01081 Bacterial regulatory proteins, tetR family signature. 282458011995 Predicted helix-turn-helix motif with score 1867 (+5.55 SD) at aa 28-49, sequence ISMNRIAKELGIGMGTLYRHFK 282458011996 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 282458011997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 282458011998 NAD(P) binding site [chemical binding]; other site 282458011999 active site 282458012000 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 132.50, E-value 7.7e-36 282458012001 PS00061 Short-chain dehydrogenases/reductases family signature. 282458012002 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 282458012003 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 282458012004 Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold, score 52.20, E-value 1.1e-11 282458012005 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 282458012006 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 282458012007 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 282458012008 Pfam match to entry PF02492 cobW, Cobalamin synthesis protein/P47K, score 37.10, E-value 4e-07 282458012009 PS00217 Sugar transport proteins signature 2. 282458012010 PS00017 ATP/GTP-binding site motif A (P-loop). 282458012011 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 282458012012 Nucleoside recognition; Region: Gate; pfam07670 282458012013 8 probable transmembrane helices predicted for SAR2663 by TMHMM2.0 at aa 86-108, 150-172, 231-253, 257-276, 312-334, 344-366, 390-412 and 427-446 282458012014 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 282458012015 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 282458012016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 282458012017 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 282458012018 Phosphotransferase enzyme family; Region: APH; pfam01636 282458012019 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 282458012020 active site 282458012021 ATP binding site [chemical binding]; other site 282458012022 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 282458012023 active site 282458012024 ATP binding site [chemical binding]; other site 282458012025 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 282458012026 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 282458012027 quinone interaction residues [chemical binding]; other site 282458012028 active site 282458012029 catalytic residues [active] 282458012030 FMN binding site [chemical binding]; other site 282458012031 substrate binding site [chemical binding]; other site 282458012032 Pfam match to entry PF01180 DHOdehase, Dihydroorotate dehydrogenase, score 299.20, E-value 5.1e-86 282458012033 PS00911 Dihydroorotate dehydrogenase signature 1. 282458012034 PS00912 Dihydroorotate dehydrogenase signature 2. 282458012035 1 probable transmembrane helix predicted for SAR2670 by TMHMM2.0 at aa 69-88 282458012036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 282458012037 Pfam match to entry PF02677 DUF208, Uncharacterized BCR, COG1636, score 135.40, E-value 1e-36 282458012038 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 282458012039 dimer interface [polypeptide binding]; other site 282458012040 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 282458012041 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 282458012042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 282458012043 Predicted helix-turn-helix motif for SAR2673 with score 1202.000, SD 3.28 at aa 30-51, sequence ITVQQIADLADVNRSTFYTHYY 282458012044 Predicted acyl esterases [General function prediction only]; Region: COG2936 282458012045 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 282458012046 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 282458012047 tetramerization interface [polypeptide binding]; other site 282458012048 active site 282458012049 Pfam match to entry PF02261 Asp_decarbox, Aspartate decarboxylase, score 247.40, E-value 2e-70 282458012050 pantoate--beta-alanine ligase; Region: panC; TIGR00018 282458012051 Pantoate-beta-alanine ligase; Region: PanC; cd00560 282458012052 active site 282458012053 ATP-binding site [chemical binding]; other site 282458012054 pantoate-binding site; other site 282458012055 HXXH motif; other site 282458012056 Pfam match to entry PF02569 Pantoate_ligase, Pantoate-beta-alanine ligase, score 476.20, E-value 2.6e-139 282458012057 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 282458012058 oligomerization interface [polypeptide binding]; other site 282458012059 active site 282458012060 metal binding site [ion binding]; metal-binding site 282458012061 Pfam match to entry PF02548 Pantoate_transf, Ketopantoate hydroxymethyltransferase, score 411.00, E-value 1.1e-119 282458012062 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 282458012063 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 282458012064 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 282458012065 Pfam match to entry PF02558 ApbA, Ketopantoate reductase PanE/ApbA, score 120.50, E-value 3.2e-32 282458012066 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 282458012067 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 282458012068 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 282458012069 tetramer (dimer of dimers) interface [polypeptide binding]; other site 282458012070 NAD binding site [chemical binding]; other site 282458012071 dimer interface [polypeptide binding]; other site 282458012072 substrate binding site [chemical binding]; other site 282458012073 Pfam match to entry PF02866 ldh_C, lactate/malate dehydrogenase, alpha/beta C-terminal domain, score 236.90, E-value 3e-67 282458012074 PS00064 L-lactate dehydrogenase active site. 282458012075 Pfam match to entry PF00056 ldh, lactate/malate dehydrogenase, NAD binding domain, score 239.50, E-value 4.8e-68 282458012076 Signal peptide predicted for SAR2681 by SignalP 2.0 HMM (Signal peptide probabilty 0.933) with cleavage site probability 0.852 between residues 55 and 56; signal peptide 282458012077 amino acid transporter; Region: 2A0306; TIGR00909 282458012078 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score -45.20, E-value 6.6e-11 282458012079 12 probable transmembrane helices predicted for SAR2681 by TMHMM2.0 at aa 33-55, 59-81, 93-115, 155-174, 187-209, 229-246, 267-289, 309-331, 365-384, 388-405, 422-444 and 449-466 282458012080 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 282458012081 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 282458012082 inhibitor-cofactor binding pocket; inhibition site 282458012083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458012084 catalytic residue [active] 282458012085 Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III, score 406.80, E-value 1.1e-121 282458012086 Signal peptide predicted for SAR2683 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.669 between residues 32 and 33; signal peptide 282458012087 4 probable transmembrane helices predicted for SAR2683 by TMHMM2.0 at aa 7-29, 52-74, 81-103 and 113-135 282458012088 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 282458012089 catalytic residue [active] 282458012090 Pfam match to entry PF00274 glycolytic_enzy, Fructose-bisphosphate aldolase class-I, score 285.20, E-value 8.1e-82 282458012091 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 282458012092 Signal peptide predicted for SAR2685 by SignalP 2.0 HMM (Signal peptide probabilty 0.663) with cleavage site probability 0.637 between residues 27 and 28; signal peptide 282458012093 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 282458012094 2 probable transmembrane helices predicted for SAR2686 by TMHMM2.0 at aa 5-22 and 37-59 282458012095 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 282458012096 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 282458012097 acyl-activating enzyme (AAE) consensus motif; other site 282458012098 AMP binding site [chemical binding]; other site 282458012099 active site 282458012100 CoA binding site [chemical binding]; other site 282458012101 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 364.00, E-value 1.6e-105 282458012102 PS00455 AMP-binding domain signature. 282458012103 PS00211 ABC transporters family signature. 282458012104 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 282458012105 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 282458012106 choline dehydrogenase; Validated; Region: PRK02106 282458012107 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 282458012108 Pfam match to entry PF00732 GMC_oxred, GMC oxidoreductases, score 699.10, E-value 2.1e-206 282458012109 PS00624 GMC oxidoreductases signature 2. 282458012110 PS00623 GMC oxidoreductases signature 1. 282458012111 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 282458012112 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 282458012113 tetramerization interface [polypeptide binding]; other site 282458012114 NAD(P) binding site [chemical binding]; other site 282458012115 catalytic residues [active] 282458012116 Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase, score 703.50, E-value 9.8e-208 282458012117 PS00070 Aldehyde dehydrogenases cysteine active site. 282458012118 PS00687 Aldehyde dehydrogenases glutamic acid active site. 282458012119 Predicted transcriptional regulators [Transcription]; Region: COG1510 282458012120 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 282458012121 Signal peptide predicted for SAR2693 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.546 between residues 32 and 33; signal peptide 282458012122 Pfam match to entry PF02028 BCCT, BCCT family transporter, score 471.40, E-value 7.2e-138 282458012123 12 probable transmembrane helices predicted for SAR2693 by TMHMM2.0 at aa 12-29, 44-66, 87-109, 140-162, 192-214, 229-248, 260-282, 321-343, 356-378, 413-435, 448-470 and 483-505 282458012124 PS01303 BCCT family of transporters signature. 282458012125 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282458012126 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 282458012127 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282458012128 FeS/SAM binding site; other site 282458012129 Pfam match to entry PF02143 Radical_activat, Radical activating enzyme, score 46.40, E-value 6.5e-10 282458012130 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 282458012131 Class III ribonucleotide reductase; Region: RNR_III; cd01675 282458012132 effector binding site; other site 282458012133 active site 282458012134 Zn binding site [ion binding]; other site 282458012135 glycine loop; other site 282458012136 Pfam match to entry PF01228 Gly_radical, Glycine radical, score 109.20, E-value 8e-29 282458012137 PS00850 Glycine radical signature. 282458012138 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 282458012139 Citrate transporter; Region: CitMHS; pfam03600 282458012140 12 probable transmembrane helices predicted for SAR2696 by TMHMM2.0 at aa 5-24, 31-53, 63-80, 93-115, 120-139, 144-166, 181-203, 257-290, 305-327, 340-362, 398-420 and 432-454 282458012141 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 282458012142 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 282458012143 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 282458012144 Flavodoxin; Region: Flavodoxin_1; pfam00258 282458012145 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 282458012146 FAD binding pocket [chemical binding]; other site 282458012147 FAD binding motif [chemical binding]; other site 282458012148 catalytic residues [active] 282458012149 NAD binding pocket [chemical binding]; other site 282458012150 phosphate binding motif [ion binding]; other site 282458012151 beta-alpha-beta structure motif; other site 282458012152 Pfam match to entry PF00175 NAD_binding, Oxidoreductase FAD/NAD-binding domain, score 129.00, E-value 8.7e-35 282458012153 Pfam match to entry PF00667 FAD_binding, FAD binding domain, score 53.60, E-value 1.6e-13 282458012154 Pfam match to entry PF00667 FAD_binding, FAD binding domain, score 51.50, E-value 6.3e-13 282458012155 Pfam match to entry PF00258 flavodoxin, Flavodoxin, score 158.10, E-value 3.9e-45 282458012156 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 282458012157 catalytic residues [active] 282458012158 dimer interface [polypeptide binding]; other site 282458012159 Pfam match to entry PF00255 GSHPx, Glutathione peroxidase, score 117.10, E-value 1.5e-31 282458012160 FtsX-like permease family; Region: FtsX; pfam02687 282458012161 10 probable transmembrane helices predicted for SAR2700 by TMHMM2.0 at aa 21-43, 53-75, 113-135, 155-177, 198-217, 232-254, 284-306, 538-560, 596-618 and 628-650 282458012162 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 282458012163 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282458012164 Walker A/P-loop; other site 282458012165 ATP binding site [chemical binding]; other site 282458012166 Q-loop/lid; other site 282458012167 ABC transporter signature motif; other site 282458012168 Walker B; other site 282458012169 D-loop; other site 282458012170 H-loop/switch region; other site 282458012171 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 211.20, E-value 1.6e-59 282458012172 PS00211 ABC transporters family signature. 282458012173 PS00017 ATP/GTP-binding site motif A (P-loop). 282458012174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 282458012175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282458012176 ATP binding site [chemical binding]; other site 282458012177 Mg2+ binding site [ion binding]; other site 282458012178 G-X-G motif; other site 282458012179 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 88.00, E-value 5.6e-23 282458012180 2 probable transmembrane helices predicted for SAR2702 by TMHMM2.0 at aa 13-30 and 35-57 282458012181 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282458012182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282458012183 active site 282458012184 phosphorylation site [posttranslational modification] 282458012185 intermolecular recognition site; other site 282458012186 dimerization interface [polypeptide binding]; other site 282458012187 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282458012188 DNA binding site [nucleotide binding] 282458012189 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 50.20, E-value 1.2e-13 282458012190 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 101.50, E-value 1.6e-26 282458012191 1 probable transmembrane helix predicted for SAR2704 by TMHMM2.0 at aa 4-21 282458012192 Similar to Bacillus subtilis alkaline phosphatase III precursor PhoB SW:PPB3_BACSU (P19405) (462 aa) fasta scores: E(): 9e-60, 47.66% id in 470 aa, and to Lactobacillus delbrueckii alkaline phosphatase TR:Q9F5J7 (EMBL:AF320303) (471 aa) fasta scores: E(): 1.2e-59, 47.76% id in 469 aa. CDS is disrupted by the insertion of an IS element after codon 4;alkaline phosphatase III precursor (pseudogene) 282458012193 Signal peptide predicted for SAR2706 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.680 between residues 30 and 31 282458012194 insertion sequence ISX 282458012195 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 282458012196 Helix-turn-helix domain; Region: HTH_38; pfam13936 282458012197 Integrase core domain; Region: rve; pfam00665 282458012198 Predicted helix-turn-helix motif with score 1647 (+4.80 SD) at aa 22-43, sequence YSLRSIARKLKRSVSTISREIS 282458012199 Pfam match to entry PF00665 rve, Integrase core domain, score 119.70, E-value 2.1e-33 282458012200 PS01043 Transposases, IS30 family, signature. 282458012201 Pfam match to entry PF00245 alk_phosphatase, Alkaline phosphatase, score 361.90, E-value 6.6e-105 282458012202 PS00123 Alkaline phosphatase active site. 282458012203 PS00017 ATP/GTP-binding site motif A (P-loop). 282458012204 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 282458012205 1 probable transmembrane helix predicted for SAR2706a by TMHMM2.0 at aa 4-18 282458012206 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 282458012207 MarR family; Region: MarR_2; pfam12802 282458012208 Predicted esterase [General function prediction only]; Region: COG0627 282458012209 S-formylglutathione hydrolase; Region: PLN02442 282458012210 Signal peptide predicted for SAR2709 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.679 between residues 44 and 45; signal peptide 282458012211 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282458012212 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 282458012213 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 282458012214 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 27.80, E-value 0.00025 282458012215 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282458012216 1 probable transmembrane helix predicted for SAR2709 by TMHMM2.0 at aa 20-37 282458012217 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 282458012218 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 282458012219 ligand binding site [chemical binding]; other site 282458012220 flexible hinge region; other site 282458012221 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 282458012222 Predicted helix-turn-helix motif with score 1236 (+3.40 SD) at aa 186-207, sequence LTIQLMSDMAGISRETAGHIIH 282458012223 carbamate kinase; Reviewed; Region: PRK12686 282458012224 Signal peptide predicted for SAR2711 by SignalP 2.0 HMM (Signal peptide probabilty 0.689) with cleavage site probability 0.242 between residues 30 and 31; signal peptide 282458012225 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 282458012226 putative substrate binding site [chemical binding]; other site 282458012227 nucleotide binding site [chemical binding]; other site 282458012228 nucleotide binding site [chemical binding]; other site 282458012229 homodimer interface [polypeptide binding]; other site 282458012230 Pfam match to entry PF00696 aakinase, Amino acid kinase, score 281.60, E-value 1e-80 282458012231 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 282458012232 14 probable transmembrane helices predicted for SAR2712 by TMHMM2.0 at aa 15-33, 40-62, 77-99, 101-123, 128-147, 159-181, 211-230, 243-265, 280-302, 336-358, 362-384, 401-418, 423-440 and 453-475 282458012233 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score -232.50, E-value 0.00047 282458012234 ornithine carbamoyltransferase; Validated; Region: PRK02102 282458012235 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 282458012236 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 282458012237 Pfam match to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain, score 261.70, E-value 2e-76 282458012238 Pfam match to entry PF02729 OTCace_N, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain, score 236.10, E-value 4.9e-67 282458012239 PS00097 Aspartate and ornithine carbamoyltransferases signature. 282458012240 arginine deiminase; Provisional; Region: PRK01388 282458012241 Pfam match to entry PF02726 Arg_deiminase, Arginine deiminase, score 401.70, E-value 7.3e-117 282458012242 Arginine repressor [Transcription]; Region: ArgR; COG1438 282458012243 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 282458012244 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 282458012245 Pfam match to entry PF02863 Arg_repressor_C, Arginine repressor, C-terminal domain, score 44.30, E-value 4.6e-11 282458012246 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 282458012247 Signal peptide predicted for SAR2716 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.920 between residues 27 and 28; signal peptide 282458012248 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 282458012249 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 282458012250 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 282458012251 active site 282458012252 Zn binding site [ion binding]; other site 282458012253 Pfam match to entry PF02868 Peptidase_M4_C, Thermolysin metallopeptidase, alpha-helical domain, score 301.40, E-value 1.1e-86 282458012254 Pfam match to entry PF01447 Peptidase_M4, Thermolysin metallopeptidase, catalytic domain, score 229.50, E-value 4.7e-65 282458012255 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282458012256 Signal peptide predicted for SAR2717 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 36 and 37; signal peptide 282458012257 1 probable transmembrane helix predicted for SAR2717 by TMHMM2.0 at aa 7-29 282458012258 Signal peptide predicted for SAR2718 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.602 between residues 23 and 24; signal peptide 282458012259 1 probable transmembrane helix predicted for SAR2718 by TMHMM2.0 at aa 4-26 282458012260 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 282458012261 HTH domain; Region: HTH_11; pfam08279 282458012262 PRD domain; Region: PRD; pfam00874 282458012263 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 282458012264 active site 282458012265 P-loop; other site 282458012266 phosphorylation site [posttranslational modification] 282458012267 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282458012268 active site 282458012269 phosphorylation site [posttranslational modification] 282458012270 Predicted helix-turn-helix motif with score 1430 (+4.06 SD) at aa 20-41, sequence ISSNEIAEHVNVSNRTVRNDIH 282458012271 Pfam match to entry PF00874 BglG_antitermin, Transcriptional antiterminator bglG family, score 39.50, E-value 7.8e-08 282458012272 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score -8.80, E-value 6e-05 282458012273 PS00372 PTS EIIA domains phosphorylation site signature 2. 282458012274 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 282458012275 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 282458012276 active site 282458012277 P-loop; other site 282458012278 phosphorylation site [posttranslational modification] 282458012279 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 282458012280 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282458012281 active site 282458012282 phosphorylation site [posttranslational modification] 282458012283 Pfam match to entry PF02379 PTS_IIB_fruc, PTS system, Fructose specific IIB subunit, score 189.90, E-value 4.1e-53 282458012284 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 207.20, E-value 2.6e-58 282458012285 8 probable transmembrane helices predicted for SAR2720 by TMHMM2.0 at aa 133-155, 175-197, 218-240, 255-277, 298-317, 337-359, 398-417 and 437-459 282458012286 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 30.60, E-value 3.1e-08 282458012287 PS00372 PTS EIIA domains phosphorylation site signature 2. 282458012288 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 282458012289 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 282458012290 Pfam match to entry PF01238 PMI_typeI, Phosphomannose isomerase type I, score 229.30, E-value 5.7e-65 282458012291 Signal peptide predicted for SAR2722 by SignalP 2.0 HMM (Signal peptide probabilty 0.654) with cleavage site probability 0.434 between residues 36 and 37; signal peptide 282458012292 Predicted membrane protein [Function unknown]; Region: COG1511 282458012293 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 282458012294 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 282458012295 6 probable transmembrane helices predicted for SAR2722 by TMHMM2.0 at aa 21-43, 793-815, 836-858, 868-890, 897-919 and 949-971 282458012296 Signal peptide predicted for SAR2723 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.989 between residues 27 and 28; signal peptide 282458012297 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 282458012298 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 282458012299 CHAP domain; Region: CHAP; pfam05257 282458012300 Pfam match to entry PF01832 Amidase_4, N-acetylmuramoyl-L-alanine amidase, score 150.40, E-value 3.1e-41 282458012301 Isochorismatase family; Region: Isochorismatase; pfam00857 282458012302 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 282458012303 catalytic triad [active] 282458012304 conserved cis-peptide bond; other site 282458012305 Pfam match to entry PF00857 Isochorismatase, Isochorismatase, score 63.90, E-value 3.3e-15 282458012306 Signal peptide predicted for SAR2725 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.694 between residues 37 and 38; signal peptide 282458012307 1 probable transmembrane helix predicted for SAR2725 by TMHMM2.0 at aa 599-618 282458012308 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 282458012309 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 282458012310 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 282458012311 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 282458012312 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 72.80, E-value 5e-19 282458012313 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 282458012314 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 282458012315 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 282458012316 Pfam match to entry PF01043 SecA_protein, SecA protein, amino terminal region, score 509.50, E-value 1.5e-167 282458012317 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 282458012318 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 282458012319 Similar to Streptococcus pneumoniae hypothetical protein SP1762 TR:Q97P80 (EMBL:AE007468) (526 aa) fasta scores: E(): 5.5e-43, 30.22% id in 526 aa, and to Streptococcus gordonii hypothetical protein TR:Q9AET9 (EMBL:AY028381) (526 aa) fasta scores: E(): 2.5e-42, 32.06% id in 527 aa Contains a nonsense mutation (ochre) after codon 452;conserved hypothetical protein (pseudogene) 282458012320 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 282458012321 SecY translocase; Region: SecY; pfam00344 282458012322 10 probable transmembrane helices predicted for SAR2733 by TMHMM2.0 at aa 17-39, 63-85, 105-123, 133-151, 158-177, 187-209, 230-252, 280-302, 337-359 and 369-391 282458012323 Pfam match to entry PF00344 secY, eubacterial secY protein, score -34.80, E-value 7.5e-11 282458012324 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 282458012325 legume lectins; Region: lectin_L-type; cd01951 282458012326 homotetramer interaction site [polypeptide binding]; other site 282458012327 carbohydrate binding site [chemical binding]; other site 282458012328 metal binding site [ion binding]; metal-binding site 282458012329 Putative Ig domain; Region: He_PIG; pfam05345 282458012330 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 25.40, E-value 0.0014 282458012331 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282458012332 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 282458012333 No significant database matches. Possible pseudogene; lipoprotein (pseudogene) 282458012334 Signal peptide predicted for SAR2736 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.420 between residues 24 and 25 282458012335 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458012336 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 282458012337 methionine sulfoxide reductase A; Provisional; Region: PRK05528 282458012338 Pfam match to entry PF01625 PMSR, Peptide methionine sulfoxide reductase, score 109.30, E-value 7.3e-29 282458012339 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 282458012340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282458012341 Coenzyme A binding pocket [chemical binding]; other site 282458012342 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 68.40, E-value 1.5e-16 282458012343 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 282458012344 Pfam match to entry PF02811 PHP_C, PHP domain C-terminal region, score 28.70, E-value 0.00013 282458012345 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 282458012346 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 282458012347 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 282458012348 Signal peptide predicted for SAR2745 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.521 between residues 39 and 40; signal peptide 282458012349 Chain length determinant protein; Region: Wzz; cl15801 282458012350 2 probable transmembrane helices predicted for SAR2745 by TMHMM2.0 at aa 20-39 and 169-191 282458012351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 282458012352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 282458012353 Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 59.10, E-value 9.3e-14 282458012354 Predicted helix-turn-helix motif with score 1314 (+3.66 SD) at aa 21-42, sequence TTLDDIAKSVNIKKASLYYHFD 282458012355 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 282458012356 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 282458012357 DXD motif; other site 282458012358 4 probable transmembrane helices predicted for SAR2747 by TMHMM2.0 at aa 6-28, 290-312, 332-354 and 366-388 282458012359 Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferase, score 127.30, E-value 2.8e-34 282458012360 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 282458012361 2 probable transmembrane helices predicted for SAR2748 by TMHMM2.0 at aa 24-46 and 71-93 282458012362 Signal peptide predicted for SAR2749 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.982 between residues 30 and 31; signal peptide 282458012363 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 282458012364 1 probable transmembrane helix predicted for SAR2749 by TMHMM2.0 at aa 7-29 282458012365 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 282458012366 Acyltransferase family; Region: Acyl_transf_3; pfam01757 282458012367 10 probable transmembrane helices predicted for SAR2750 by TMHMM2.0 at aa 7-29, 44-66, 79-101, 116-138, 145-167, 187-204, 211-233, 243-262, 269-291 and 306-328 282458012368 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 282458012369 Signal peptide predicted for SAR2753 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.969 between residues 35 and 36; signal peptide 282458012370 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 282458012371 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 282458012372 PS00120 Lipases, serine active site. 282458012373 PS00017 ATP/GTP-binding site motif A (P-loop). 282458012374 1 probable transmembrane helix predicted for SAR2753 by TMHMM2.0 at aa 13-35 282458012375 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 282458012376 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 282458012377 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 282458012378 metal binding site [ion binding]; metal-binding site 282458012379 Pfam match to entry PF01503 PRA-PH, Phosphoribosyl-ATP pyrophosphohydrolase, score 111.60, E-value 1.5e-29 282458012380 Pfam match to entry PF01502 PRA-CH, Phosphoribosyl-AMP cyclohydrolase, score 153.80, E-value 3e-42 282458012381 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 282458012382 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 282458012383 substrate binding site [chemical binding]; other site 282458012384 glutamase interaction surface [polypeptide binding]; other site 282458012385 Pfam match to entry PF00977 His_biosynth, Histidine biosynthesis protein, score 383.20, E-value 2.6e-111 282458012386 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 282458012387 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 282458012388 catalytic residues [active] 282458012389 Pfam match to entry PF00977 His_biosynth, Histidine biosynthesis protein, score 62.80, E-value 7.6e-15 282458012390 PS00152 ATP synthase alpha and beta subunits signature. 282458012391 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 282458012392 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 282458012393 putative active site [active] 282458012394 oxyanion strand; other site 282458012395 catalytic triad [active] 282458012396 Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I, score 90.60, E-value 3.3e-23 282458012397 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 282458012398 putative active site pocket [active] 282458012399 4-fold oligomerization interface [polypeptide binding]; other site 282458012400 metal binding residues [ion binding]; metal-binding site 282458012401 3-fold/trimer interface [polypeptide binding]; other site 282458012402 Pfam match to entry PF00475 IGPD, Imidazoleglycerol-phosphate dehydratase, score 231.70, E-value 9.8e-79 282458012403 PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. 282458012404 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 282458012405 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 282458012406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282458012407 homodimer interface [polypeptide binding]; other site 282458012408 catalytic residue [active] 282458012409 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class-I, score 46.10, E-value 7.9e-10 282458012410 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 282458012411 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 282458012412 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 282458012413 NAD binding site [chemical binding]; other site 282458012414 dimerization interface [polypeptide binding]; other site 282458012415 product binding site; other site 282458012416 substrate binding site [chemical binding]; other site 282458012417 zinc binding site [ion binding]; other site 282458012418 catalytic residues [active] 282458012419 Pfam match to entry PF00815 Histidinol_dh, Histidinol dehydrogenase, score 458.00, E-value 8.2e-134 282458012420 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 282458012421 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 282458012422 Pfam match to entry PF01634 HisG, ATP phosphoribosyltransferase, score 173.80, E-value 2.8e-48 282458012423 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 282458012424 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 282458012425 Signal peptide predicted for SAR2763 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.968 between residues 28 and 29; signal peptide 282458012426 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 282458012427 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 282458012428 putative active site [active] 282458012429 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282458012430 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 282458012431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 282458012432 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 282458012433 5 probable transmembrane helices predicted for SAR2765 by TMHMM2.0 at aa 21-38, 43-60, 67-86, 115-137 and 248-267 282458012434 Pfam match to entry PF02361 CbiQ, Cobalt transport protein, score 93.90, E-value 3.1e-24 282458012435 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 282458012436 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 282458012437 Walker A/P-loop; other site 282458012438 ATP binding site [chemical binding]; other site 282458012439 Q-loop/lid; other site 282458012440 ABC transporter signature motif; other site 282458012441 Walker B; other site 282458012442 D-loop; other site 282458012443 H-loop/switch region; other site 282458012444 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 282458012445 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 282458012446 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 282458012447 Walker A/P-loop; other site 282458012448 ATP binding site [chemical binding]; other site 282458012449 Q-loop/lid; other site 282458012450 ABC transporter signature motif; other site 282458012451 Walker B; other site 282458012452 D-loop; other site 282458012453 H-loop/switch region; other site 282458012454 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 169.90, E-value 4.2e-47 282458012455 PS00211 ABC transporters family signature. 282458012456 PS00017 ATP/GTP-binding site motif A (P-loop). 282458012457 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 132.10, E-value 1e-35 282458012458 PS00211 ABC transporters family signature. 282458012459 PS00017 ATP/GTP-binding site motif A (P-loop). 282458012460 Signal peptide predicted for SAR2767 by SignalP 2.0 HMM (Signal peptide probabilty 0.875) with cleavage site probability 0.286 between residues 44 and 45; signal peptide 282458012461 hypothetical protein; Provisional; Region: PRK13661 282458012462 5 probable transmembrane helices predicted for SAR2767 by TMHMM2.0 at aa 10-29, 42-64, 79-101, 114-136 and 146-168 282458012463 Uncharacterized conserved protein [Function unknown]; Region: COG1912 282458012464 Pfam match to entry PF01887 DUF62, Protein of unknown function DUF62, score 254.00, E-value 2.1e-72 282458012465 Uncharacterized conserved protein [Function unknown]; Region: COG2353 282458012466 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 282458012467 Strictosidine synthase; Region: Str_synth; pfam03088 282458012468 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 282458012469 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 282458012470 active site residue [active] 282458012471 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 282458012472 Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain, score 71.40, E-value 2e-17 282458012473 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 282458012474 putative substrate binding pocket [chemical binding]; other site 282458012475 AC domain interface; other site 282458012476 catalytic triad [active] 282458012477 AB domain interface; other site 282458012478 interchain disulfide; other site 282458012479 Pfam match to entry PF01470 Peptidase_C15, Pyroglutamyl peptidase, score 489.70, E-value 2.3e-143 282458012480 PS01333 Pyrrolidone-carboxylate peptidase glutamic acid active site. 282458012481 PS01334 Pyrrolidone-carboxylate peptidase cysteine active site. 282458012482 DinB superfamily; Region: DinB_2; pfam12867 282458012483 Signal peptide predicted for SAR2774 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.986 between residues 29 and 30; signal peptide 282458012484 Collagen binding domain; Region: Collagen_bind; pfam05737 282458012485 Cna protein B-type domain; Region: Cna_B; pfam05738 282458012486 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 282458012487 domain interaction interfaces [polypeptide binding]; other site 282458012488 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 282458012489 domain interaction interfaces [polypeptide binding]; other site 282458012490 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 282458012491 domain interaction interfaces [polypeptide binding]; other site 282458012492 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 282458012493 domain interaction interfaces [polypeptide binding]; other site 282458012494 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 282458012495 domain interaction interfaces [polypeptide binding]; other site 282458012496 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 282458012497 domain interaction interfaces [polypeptide binding]; other site 282458012498 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 282458012499 domain interaction interfaces [polypeptide binding]; other site 282458012500 1 probable transmembrane helix predicted for SAR2774 by TMHMM2.0 at aa 1158-1177 282458012501 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 282458012502 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 282458012503 transmembrane helices; other site 282458012504 Pfam match to entry PF00939 Na_sulph_symp, Sodium:sulfate symporter transmembrane region, score 686.10, E-value 1.8e-202 282458012505 12 probable transmembrane helices predicted for SAR2775 by TMHMM2.0 at aa 7-24, 34-51, 56-73, 78-100, 174-196, 216-238, 272-290, 294-313, 326-348, 358-380, 392-414 and 443-465 282458012506 Predicted permeases [General function prediction only]; Region: RarD; COG2962 282458012507 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 282458012508 10 probable transmembrane helices predicted for SAR2776 by TMHMM2.0 at aa 7-29, 34-56, 77-99, 103-125, 132-149, 154-172, 179-201, 216-235, 240-262 and 272-291 282458012509 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6, score 33.40, E-value 5.3e-06 282458012510 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6, score 49.00, E-value 1e-10 282458012511 hypothetical protein; Provisional; Region: PRK07758 282458012512 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 282458012513 Predicted helix-turn-helix motif with score 1265 (+3.50 SD) at aa 28-49, sequence YTKSSLMEMHGVGPKAISILEQ 282458012514 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 282458012515 7 probable transmembrane helices predicted for SAR2778 by TMHMM2.0 at aa 10-32, 79-101, 121-143, 185-207, 217-239, 260-282 and 307-329 282458012516 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 282458012517 Pfam match to entry PF00797 Acetyltransf2, N-acetyltransferase, score 9.80, E-value 6.4e-10 282458012518 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 282458012519 Signal peptide predicted for SAR2780 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.677 between residues 36 and 37; signal peptide 282458012520 6 probable transmembrane helices predicted for SAR2780 by TMHMM2.0 at aa 7-29, 33-55, 68-90, 94-116, 123-140 and 144-166 282458012521 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 282458012522 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282458012523 Walker A/P-loop; other site 282458012524 ATP binding site [chemical binding]; other site 282458012525 Q-loop/lid; other site 282458012526 ABC transporter signature motif; other site 282458012527 Walker B; other site 282458012528 D-loop; other site 282458012529 H-loop/switch region; other site 282458012530 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 194.50, E-value 1.7e-54 282458012531 PS00017 ATP/GTP-binding site motif A (P-loop). 282458012532 FtsX-like permease family; Region: FtsX; pfam02687 282458012533 10 probable transmembrane helices predicted for SAR2782 by TMHMM2.0 at aa 21-38, 58-80, 109-131, 153-175, 197-219, 229-251, 290-312, 506-528, 562-584 and 594-616 282458012534 1 probable transmembrane helix predicted for SAR2783 by TMHMM2.0 at aa 21-43 282458012535 Similar to Enterococcus faecium transposase TR:Q47812 (EMBL:L38972) (319 aa) fasta scores: E(): 2.1e-76, 63% id in 319 aa, and to Enterococcus faecalis transposase TR:Q9AL26 (EMBL:X92945) (319 aa) fasta scores: E(): 1.3e-73, 61.75% id in 319 aa. CDS is disrupted by three nonsense mutations (amber x3) after codons 19, 86 and 137;transposase (pseudogene) 282458012536 Predicted helix-turn-helix motif for SAR2784 with score 1477.000, SD 4.22 at aa 21-42, sequence LSVKEISSRLKRSRQTIYNVIN 282458012537 Pfam match to entry PF00665 rve, Integrase core domain, score 71.20, E-value 2.1e-19 282458012538 Signal peptide predicted for SAR2788 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.945 between residues 24 and 25; signal peptide 282458012539 PS00017 ATP/GTP-binding site motif A (P-loop). 282458012540 1 probable transmembrane helix predicted for SAR2788 by TMHMM2.0 at aa 5-27 282458012541 Signal peptide predicted for SAR2789 by SignalP 2.0 HMM (Signal peptide probabilty 0.710) with cleavage site probability 0.583 between residues 31 and 32; signal peptide 282458012542 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 282458012543 active site 282458012544 catalytic residues [active] 282458012545 Pfam match to entry PF00082 Peptidase_S8, Subtilase, score 70.90, E-value 1e-18 282458012546 Pfam match to entry PF00082 Peptidase_S8, Subtilase, score 3.10, E-value 7.3 282458012547 1 probable transmembrane helix predicted for SAR2789 by TMHMM2.0 at aa 5-24 282458012548 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 282458012549 DNA-binding site [nucleotide binding]; DNA binding site 282458012550 RNA-binding motif; other site 282458012551 Pfam match to entry PF00313 CSD, 'Cold-shock' DNA-binding domain, score 140.80, E-value 2.4e-38 282458012552 PS00352 'Cold-shock' DNA-binding domain signature. 282458012553 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 282458012554 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282458012555 non-specific DNA binding site [nucleotide binding]; other site 282458012556 salt bridge; other site 282458012557 sequence-specific DNA binding site [nucleotide binding]; other site 282458012558 3 probable transmembrane helices predicted for SAR2791 by TMHMM2.0 at aa 80-102, 106-123 and 163-185 282458012559 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 65.50, E-value 1.1e-15 282458012560 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 282458012561 4 probable transmembrane helices predicted for SAR2792 by TMHMM2.0 at aa 5-27, 31-53, 60-82 and 92-114 282458012562 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 282458012563 4 probable transmembrane helices predicted for SAR2793 by TMHMM2.0 at aa 4-25, 32-51, 66-88 and 95-114 282458012564 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 282458012565 ParB-like nuclease domain; Region: ParBc; pfam02195 282458012566 PS00017 ATP/GTP-binding site motif A (P-loop). 282458012567 Predicted helix-turn-helix motif for SAR2795 with score 1898.000, SD 5.65 at aa 143-164, sequence TTQSELAKSLGKSQSFIANKLR 282458012568 Pfam match to entry PF02195 ParBc, ParB-like nuclease domain, score 122.60, E-value 7.3e-33 282458012569 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 282458012570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282458012571 S-adenosylmethionine binding site [chemical binding]; other site 282458012572 Pfam match to entry PF02527 GidB, Glucose inhibited division protein, score 270.90, E-value 1.7e-77 282458012573 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 282458012574 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 282458012575 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 282458012576 Pfam match to entry PF01134 GIDA, Glucose inhibited division protein A, score 1386.50, E-value 0 282458012577 Predicted helix-turn-helix motif for SAR2797 with score 1139.000, SD 3.07 at aa 592-613, sequence LNIAQASRISGVNPADISILLI 282458012578 PS01281 Glucose inhibited division protein A family signature 2. 282458012579 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 282458012580 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 282458012581 trmE is a tRNA modification GTPase; Region: trmE; cd04164 282458012582 G1 box; other site 282458012583 GTP/Mg2+ binding site [chemical binding]; other site 282458012584 Switch I region; other site 282458012585 G2 box; other site 282458012586 Switch II region; other site 282458012587 G3 box; other site 282458012588 G4 box; other site 282458012589 G5 box; other site 282458012590 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 282458012591 Pfam match to entry PF01926 MMR_HSR1, GTPase of unknown function, score 6.10, E-value 3.2e-07 282458012592 PS00017 ATP/GTP-binding site motif A (P-loop). 282458012593 ribonuclease P; Reviewed; Region: rnpA; PRK00499 282458012594 Pfam match to entry PF00825 Ribonuclease_P, Ribonuclease P, score 105.60, E-value 9.6e-28 282458012595 PS00648 Bacterial ribonuclease P protein component signature. 282458012596 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 282458012597 Pfam match to entry PF00468 Ribosomal_L34, Ribosomal protein L34, score 75.60, E-value 8.9e-21 282458012598 PS00784 Ribosomal protein L34 signature.