-- dump date 20140620_074251 -- class Genbank::misc_feature -- table misc_feature_note -- id note 985002000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 985002000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 985002000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002000004 Walker A motif; other site 985002000005 ATP binding site [chemical binding]; other site 985002000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 985002000007 Walker B motif; other site 985002000008 arginine finger; other site 985002000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 985002000010 DnaA box-binding interface [nucleotide binding]; other site 985002000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 985002000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 985002000013 putative DNA binding surface [nucleotide binding]; other site 985002000014 dimer interface [polypeptide binding]; other site 985002000015 beta-clamp/clamp loader binding surface; other site 985002000016 beta-clamp/translesion DNA polymerase binding surface; other site 985002000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 985002000018 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 985002000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 985002000020 Walker A/P-loop; other site 985002000021 ATP binding site [chemical binding]; other site 985002000022 Q-loop/lid; other site 985002000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 985002000024 ABC transporter signature motif; other site 985002000025 Walker B; other site 985002000026 D-loop; other site 985002000027 H-loop/switch region; other site 985002000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 985002000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002000030 Mg2+ binding site [ion binding]; other site 985002000031 G-X-G motif; other site 985002000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 985002000033 anchoring element; other site 985002000034 dimer interface [polypeptide binding]; other site 985002000035 ATP binding site [chemical binding]; other site 985002000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 985002000037 active site 985002000038 putative metal-binding site [ion binding]; other site 985002000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 985002000040 DNA gyrase subunit A; Validated; Region: PRK05560 985002000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 985002000042 CAP-like domain; other site 985002000043 active site 985002000044 primary dimer interface [polypeptide binding]; other site 985002000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 985002000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 985002000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 985002000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 985002000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 985002000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 985002000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 985002000052 putative substrate binding site [chemical binding]; other site 985002000053 putative ATP binding site [chemical binding]; other site 985002000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 985002000055 active sites [active] 985002000056 tetramer interface [polypeptide binding]; other site 985002000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 985002000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 985002000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 985002000060 dimer interface [polypeptide binding]; other site 985002000061 active site 985002000062 motif 1; other site 985002000063 motif 2; other site 985002000064 motif 3; other site 985002000065 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 985002000066 Predicted membrane protein [Function unknown]; Region: COG4392 985002000067 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 985002000068 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 985002000069 Predicted membrane protein [Function unknown]; Region: COG4241 985002000070 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 985002000071 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 985002000072 DHH family; Region: DHH; pfam01368 985002000073 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 985002000074 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 985002000075 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 985002000076 replicative DNA helicase; Region: DnaB; TIGR00665 985002000077 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 985002000078 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 985002000079 Walker A motif; other site 985002000080 ATP binding site [chemical binding]; other site 985002000081 Walker B motif; other site 985002000082 DNA binding loops [nucleotide binding] 985002000083 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 985002000084 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 985002000085 GDP-binding site [chemical binding]; other site 985002000086 ACT binding site; other site 985002000087 IMP binding site; other site 985002000088 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 985002000089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002000090 active site 985002000091 phosphorylation site [posttranslational modification] 985002000092 intermolecular recognition site; other site 985002000093 dimerization interface [polypeptide binding]; other site 985002000094 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 985002000095 DNA binding site [nucleotide binding] 985002000096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 985002000097 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 985002000098 dimerization interface [polypeptide binding]; other site 985002000099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 985002000100 putative active site [active] 985002000101 heme pocket [chemical binding]; other site 985002000102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 985002000103 dimer interface [polypeptide binding]; other site 985002000104 phosphorylation site [posttranslational modification] 985002000105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002000106 ATP binding site [chemical binding]; other site 985002000107 Mg2+ binding site [ion binding]; other site 985002000108 G-X-G motif; other site 985002000109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 985002000110 YycH protein; Region: YycH; pfam07435 985002000111 YycH protein; Region: YycI; cl02015 985002000112 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 985002000113 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 985002000114 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 985002000115 putative active site [active] 985002000116 putative metal binding site [ion binding]; other site 985002000117 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 985002000118 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 985002000119 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 985002000120 type IVa SCCmec 985002000121 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 985002000122 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 985002000123 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 985002000124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 985002000125 Integrase core domain; Region: rve; pfam00665 985002000126 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 985002000127 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 985002000128 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 985002000129 putative active site [active] 985002000130 catalytic site [active] 985002000131 putative metal binding site [ion binding]; other site 985002000132 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 985002000133 putative active site [active] 985002000134 putative catalytic site [active] 985002000135 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 985002000136 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 985002000137 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 985002000138 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 985002000139 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 985002000140 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 985002000141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 985002000142 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 985002000143 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 985002000144 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 985002000145 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 985002000146 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 985002000147 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 985002000148 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 985002000149 catalytic residues [active] 985002000150 catalytic nucleophile [active] 985002000151 Presynaptic Site I dimer interface [polypeptide binding]; other site 985002000152 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 985002000153 Synaptic Flat tetramer interface [polypeptide binding]; other site 985002000154 Synaptic Site I dimer interface [polypeptide binding]; other site 985002000155 DNA binding site [nucleotide binding] 985002000156 Recombinase; Region: Recombinase; pfam07508 985002000157 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 985002000158 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 985002000159 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 985002000160 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 985002000161 catalytic residues [active] 985002000162 catalytic nucleophile [active] 985002000163 Recombinase; Region: Recombinase; pfam07508 985002000164 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 985002000165 Domain of unknown function (DUF927); Region: DUF927; pfam06048 985002000166 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 985002000167 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 985002000168 Divergent AAA domain; Region: AAA_4; pfam04326 985002000169 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 985002000170 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 985002000171 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 985002000172 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 985002000173 active site 985002000174 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 985002000175 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 985002000176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 985002000177 ATP binding site [chemical binding]; other site 985002000178 putative Mg++ binding site [ion binding]; other site 985002000179 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 985002000180 CRISPR spacer region 985002000181 CRISPR spacer region 985002000182 CRISPR spacer region 985002000183 CRISPR spacer region 985002000184 CRISPR spacer region 985002000185 CRISPR spacer region 985002000186 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 985002000187 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 985002000188 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 985002000189 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 985002000190 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 985002000191 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 985002000192 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 985002000193 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 985002000194 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 985002000195 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 985002000196 CRISPR spacer region 985002000197 CRISPR spacer region 985002000198 CRISPR spacer region 985002000199 CRISPR spacer region 985002000200 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 985002000201 putative active site [active] 985002000202 putative NTP binding site [chemical binding]; other site 985002000203 putative nucleic acid binding site [nucleotide binding]; other site 985002000204 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 985002000205 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 985002000206 FMN binding site [chemical binding]; other site 985002000207 active site 985002000208 catalytic residues [active] 985002000209 substrate binding site [chemical binding]; other site 985002000210 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 985002000211 FAD binding domain; Region: FAD_binding_3; pfam01494 985002000212 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 985002000213 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 985002000214 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 985002000215 MarR family; Region: MarR; pfam01047 985002000216 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 985002000217 active site 985002000218 catalytic site [active] 985002000219 putative metal binding site [ion binding]; other site 985002000220 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002000221 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002000222 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002000223 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002000224 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002000225 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 985002000226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 985002000227 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 985002000228 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 985002000229 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 985002000230 metal binding site [ion binding]; metal-binding site 985002000231 dimer interface [polypeptide binding]; other site 985002000232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002000233 putative substrate translocation pore; other site 985002000234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002000235 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 985002000236 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 985002000237 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 985002000238 PhoU domain; Region: PhoU; pfam01895 985002000239 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 985002000240 EamA-like transporter family; Region: EamA; pfam00892 985002000241 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 985002000242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 985002000243 DNA-binding site [nucleotide binding]; DNA binding site 985002000244 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 985002000245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002000246 homodimer interface [polypeptide binding]; other site 985002000247 catalytic residue [active] 985002000248 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 985002000249 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 985002000250 L-lactate permease; Region: Lactate_perm; cl00701 985002000251 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 985002000252 B domain; Region: B; pfam02216 985002000253 B domain; Region: B; pfam02216 985002000254 B domain; Region: B; pfam02216 985002000255 B domain; Region: B; pfam02216 985002000256 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 985002000257 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 985002000258 Transcriptional regulators [Transcription]; Region: MarR; COG1846 985002000259 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 985002000260 Transcriptional regulators [Transcription]; Region: MarR; COG1846 985002000261 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 985002000262 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 985002000263 ABC-ATPase subunit interface; other site 985002000264 dimer interface [polypeptide binding]; other site 985002000265 putative PBP binding regions; other site 985002000266 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 985002000267 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 985002000268 ABC-ATPase subunit interface; other site 985002000269 dimer interface [polypeptide binding]; other site 985002000270 putative PBP binding regions; other site 985002000271 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 985002000272 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 985002000273 siderophore binding site; other site 985002000274 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 985002000275 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 985002000276 dimer interface [polypeptide binding]; other site 985002000277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002000278 catalytic residue [active] 985002000279 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 985002000280 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 985002000281 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 985002000282 IucA / IucC family; Region: IucA_IucC; pfam04183 985002000283 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 985002000284 drug efflux system protein MdtG; Provisional; Region: PRK09874 985002000285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002000286 putative substrate translocation pore; other site 985002000287 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 985002000288 IucA / IucC family; Region: IucA_IucC; pfam04183 985002000289 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 985002000290 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 985002000291 IucA / IucC family; Region: IucA_IucC; pfam04183 985002000292 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 985002000293 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 985002000294 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 985002000295 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 985002000296 dimer interface [polypeptide binding]; other site 985002000297 active site 985002000298 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 985002000299 catalytic residues [active] 985002000300 substrate binding site [chemical binding]; other site 985002000301 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 985002000302 ParB-like nuclease domain; Region: ParBc; pfam02195 985002000303 acetoin reductase; Validated; Region: PRK08643 985002000304 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 985002000305 NAD binding site [chemical binding]; other site 985002000306 homotetramer interface [polypeptide binding]; other site 985002000307 homodimer interface [polypeptide binding]; other site 985002000308 active site 985002000309 substrate binding site [chemical binding]; other site 985002000310 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 985002000311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 985002000312 NAD(P) binding site [chemical binding]; other site 985002000313 active site 985002000314 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 985002000315 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 985002000316 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 985002000317 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 985002000318 putative ADP-binding pocket [chemical binding]; other site 985002000319 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 985002000320 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 985002000321 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 985002000322 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 985002000323 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 985002000324 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 985002000325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 985002000326 DNA-binding site [nucleotide binding]; DNA binding site 985002000327 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 985002000328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 985002000329 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 985002000330 intersubunit interface [polypeptide binding]; other site 985002000331 active site 985002000332 catalytic residue [active] 985002000333 phosphopentomutase; Provisional; Region: PRK05362 985002000334 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 985002000335 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 985002000336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002000337 dimer interface [polypeptide binding]; other site 985002000338 conserved gate region; other site 985002000339 putative PBP binding loops; other site 985002000340 ABC-ATPase subunit interface; other site 985002000341 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 985002000342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002000343 dimer interface [polypeptide binding]; other site 985002000344 conserved gate region; other site 985002000345 ABC-ATPase subunit interface; other site 985002000346 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 985002000347 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 985002000348 Walker A/P-loop; other site 985002000349 ATP binding site [chemical binding]; other site 985002000350 Q-loop/lid; other site 985002000351 ABC transporter signature motif; other site 985002000352 Walker B; other site 985002000353 D-loop; other site 985002000354 H-loop/switch region; other site 985002000355 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 985002000356 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 985002000357 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 985002000358 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 985002000359 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 985002000360 active site 985002000361 metal binding site [ion binding]; metal-binding site 985002000362 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 985002000363 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 985002000364 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 985002000365 putative catalytic cysteine [active] 985002000366 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 985002000367 putative active site [active] 985002000368 metal binding site [ion binding]; metal-binding site 985002000369 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 985002000370 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 985002000371 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 985002000372 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 985002000373 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 985002000374 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 985002000375 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 985002000376 NAD(P) binding site [chemical binding]; other site 985002000377 homodimer interface [polypeptide binding]; other site 985002000378 substrate binding site [chemical binding]; other site 985002000379 active site 985002000380 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 985002000381 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 985002000382 NAD(P) binding site [chemical binding]; other site 985002000383 homodimer interface [polypeptide binding]; other site 985002000384 substrate binding site [chemical binding]; other site 985002000385 active site 985002000386 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 985002000387 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 985002000388 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 985002000389 putative NAD(P) binding site [chemical binding]; other site 985002000390 active site 985002000391 putative substrate binding site [chemical binding]; other site 985002000392 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 985002000393 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 985002000394 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 985002000395 active site 985002000396 homodimer interface [polypeptide binding]; other site 985002000397 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 985002000398 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 985002000399 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 985002000400 trimer interface [polypeptide binding]; other site 985002000401 active site 985002000402 substrate binding site [chemical binding]; other site 985002000403 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 985002000404 CoA binding site [chemical binding]; other site 985002000405 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 985002000406 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 985002000407 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 985002000408 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 985002000409 Bacterial sugar transferase; Region: Bac_transf; pfam02397 985002000410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 985002000411 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 985002000412 NAD(P) binding site [chemical binding]; other site 985002000413 active site 985002000414 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 985002000415 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 985002000416 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 985002000417 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 985002000418 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 985002000419 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 985002000420 active site 985002000421 homodimer interface [polypeptide binding]; other site 985002000422 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 985002000423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 985002000424 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 985002000425 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 985002000426 NAD(P) binding site [chemical binding]; other site 985002000427 catalytic residues [active] 985002000428 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 985002000429 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 985002000430 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 985002000431 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 985002000432 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 985002000433 Walker A/P-loop; other site 985002000434 ATP binding site [chemical binding]; other site 985002000435 Q-loop/lid; other site 985002000436 ABC transporter signature motif; other site 985002000437 Walker B; other site 985002000438 D-loop; other site 985002000439 H-loop/switch region; other site 985002000440 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 985002000441 NMT1-like family; Region: NMT1_2; pfam13379 985002000442 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 985002000443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002000444 dimer interface [polypeptide binding]; other site 985002000445 conserved gate region; other site 985002000446 putative PBP binding loops; other site 985002000447 ABC-ATPase subunit interface; other site 985002000448 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 985002000449 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 985002000450 Uncharacterized conserved protein [Function unknown]; Region: COG5609 985002000451 formate dehydrogenase; Provisional; Region: PRK07574 985002000452 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 985002000453 dimerization interface [polypeptide binding]; other site 985002000454 ligand binding site [chemical binding]; other site 985002000455 NAD binding site [chemical binding]; other site 985002000456 catalytic site [active] 985002000457 Major Facilitator Superfamily; Region: MFS_1; pfam07690 985002000458 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 985002000459 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 985002000460 acyl-activating enzyme (AAE) consensus motif; other site 985002000461 AMP binding site [chemical binding]; other site 985002000462 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 985002000463 Condensation domain; Region: Condensation; pfam00668 985002000464 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 985002000465 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 985002000466 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 985002000467 AMP-binding enzyme; Region: AMP-binding; pfam00501 985002000468 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 985002000469 acyl-activating enzyme (AAE) consensus motif; other site 985002000470 AMP binding site [chemical binding]; other site 985002000471 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 985002000472 thioester reductase domain; Region: Thioester-redct; TIGR01746 985002000473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 985002000474 NAD(P) binding site [chemical binding]; other site 985002000475 active site 985002000476 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 985002000477 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 985002000478 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 985002000479 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 985002000480 nucleotide binding site [chemical binding]; other site 985002000481 N-acetyl-L-glutamate binding site [chemical binding]; other site 985002000482 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 985002000483 heterotetramer interface [polypeptide binding]; other site 985002000484 active site pocket [active] 985002000485 cleavage site 985002000486 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 985002000487 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 985002000488 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 985002000489 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 985002000490 inhibitor-cofactor binding pocket; inhibition site 985002000491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002000492 catalytic residue [active] 985002000493 Amidohydrolase; Region: Amidohydro_2; pfam04909 985002000494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 985002000495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 985002000496 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 985002000497 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 985002000498 Isochorismatase family; Region: Isochorismatase; pfam00857 985002000499 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 985002000500 catalytic triad [active] 985002000501 conserved cis-peptide bond; other site 985002000502 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 985002000503 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 985002000504 dimer interface [polypeptide binding]; other site 985002000505 PYR/PP interface [polypeptide binding]; other site 985002000506 TPP binding site [chemical binding]; other site 985002000507 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 985002000508 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 985002000509 TPP-binding site [chemical binding]; other site 985002000510 dimer interface [polypeptide binding]; other site 985002000511 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 985002000512 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 985002000513 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 985002000514 active site turn [active] 985002000515 phosphorylation site [posttranslational modification] 985002000516 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 985002000517 HPr interaction site; other site 985002000518 glycerol kinase (GK) interaction site [polypeptide binding]; other site 985002000519 active site 985002000520 phosphorylation site [posttranslational modification] 985002000521 Uncharacterized conserved protein [Function unknown]; Region: COG3589 985002000522 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 985002000523 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 985002000524 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 985002000525 putative active site [active] 985002000526 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 985002000527 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 985002000528 active site turn [active] 985002000529 phosphorylation site [posttranslational modification] 985002000530 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 985002000531 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 985002000532 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 985002000533 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 985002000534 putative active site [active] 985002000535 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 985002000536 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 985002000537 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 985002000538 ATP binding site [chemical binding]; other site 985002000539 putative Mg++ binding site [ion binding]; other site 985002000540 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 985002000541 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 985002000542 Walker A/P-loop; other site 985002000543 ATP binding site [chemical binding]; other site 985002000544 Q-loop/lid; other site 985002000545 ABC transporter signature motif; other site 985002000546 Walker B; other site 985002000547 D-loop; other site 985002000548 H-loop/switch region; other site 985002000549 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 985002000550 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 985002000551 Walker A/P-loop; other site 985002000552 ATP binding site [chemical binding]; other site 985002000553 Q-loop/lid; other site 985002000554 ABC transporter signature motif; other site 985002000555 Walker B; other site 985002000556 D-loop; other site 985002000557 H-loop/switch region; other site 985002000558 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 985002000559 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 985002000560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002000561 dimer interface [polypeptide binding]; other site 985002000562 conserved gate region; other site 985002000563 ABC-ATPase subunit interface; other site 985002000564 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 985002000565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002000566 dimer interface [polypeptide binding]; other site 985002000567 conserved gate region; other site 985002000568 ABC-ATPase subunit interface; other site 985002000569 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 985002000570 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 985002000571 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 985002000572 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 985002000573 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 985002000574 Protein of unknown function, DUF576; Region: DUF576; cl04553 985002000575 azoreductase; Reviewed; Region: PRK00170 985002000576 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 985002000577 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 985002000578 Peptidase family M23; Region: Peptidase_M23; pfam01551 985002000579 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 985002000580 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 985002000581 Walker A/P-loop; other site 985002000582 ATP binding site [chemical binding]; other site 985002000583 Q-loop/lid; other site 985002000584 ABC transporter signature motif; other site 985002000585 Walker B; other site 985002000586 D-loop; other site 985002000587 H-loop/switch region; other site 985002000588 TOBE domain; Region: TOBE; pfam03459 985002000589 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 985002000590 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 985002000591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002000592 dimer interface [polypeptide binding]; other site 985002000593 conserved gate region; other site 985002000594 ABC-ATPase subunit interface; other site 985002000595 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 985002000596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002000597 dimer interface [polypeptide binding]; other site 985002000598 conserved gate region; other site 985002000599 putative PBP binding loops; other site 985002000600 ABC-ATPase subunit interface; other site 985002000601 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 985002000602 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 985002000603 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 985002000604 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 985002000605 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 985002000606 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 985002000607 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 985002000608 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 985002000609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 985002000610 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 985002000611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002000612 putative substrate translocation pore; other site 985002000613 Response regulator receiver domain; Region: Response_reg; pfam00072 985002000614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002000615 active site 985002000616 phosphorylation site [posttranslational modification] 985002000617 intermolecular recognition site; other site 985002000618 dimerization interface [polypeptide binding]; other site 985002000619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 985002000620 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 985002000621 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 985002000622 Histidine kinase; Region: His_kinase; pfam06580 985002000623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002000624 ATP binding site [chemical binding]; other site 985002000625 Mg2+ binding site [ion binding]; other site 985002000626 G-X-G motif; other site 985002000627 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 985002000628 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 985002000629 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 985002000630 Pyruvate formate lyase 1; Region: PFL1; cd01678 985002000631 coenzyme A binding site [chemical binding]; other site 985002000632 active site 985002000633 catalytic residues [active] 985002000634 glycine loop; other site 985002000635 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 985002000636 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 985002000637 FeS/SAM binding site; other site 985002000638 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 985002000639 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 985002000640 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 985002000641 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 985002000642 putative active site [active] 985002000643 catalytic site [active] 985002000644 putative metal binding site [ion binding]; other site 985002000645 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 985002000646 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 985002000647 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 985002000648 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 985002000649 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 985002000650 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 985002000651 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 985002000652 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 985002000653 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 985002000654 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 985002000655 dimer interface [polypeptide binding]; other site 985002000656 active site 985002000657 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 985002000658 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 985002000659 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 985002000660 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 985002000661 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 985002000662 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 985002000663 substrate binding site [chemical binding]; other site 985002000664 oxyanion hole (OAH) forming residues; other site 985002000665 trimer interface [polypeptide binding]; other site 985002000666 acyl-coenzyme A oxidase; Region: PLN02526 985002000667 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 985002000668 active site 985002000669 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 985002000670 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 985002000671 acyl-activating enzyme (AAE) consensus motif; other site 985002000672 AMP binding site [chemical binding]; other site 985002000673 active site 985002000674 CoA binding site [chemical binding]; other site 985002000675 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 985002000676 Coenzyme A transferase; Region: CoA_trans; smart00882 985002000677 Coenzyme A transferase; Region: CoA_trans; cl17247 985002000678 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 985002000679 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 985002000680 catalytic triad [active] 985002000681 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 985002000682 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 985002000683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 985002000684 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 985002000685 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 985002000686 NADH(P)-binding; Region: NAD_binding_10; pfam13460 985002000687 putative NAD(P) binding site [chemical binding]; other site 985002000688 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 985002000689 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 985002000690 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 985002000691 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 985002000692 Uncharacterized conserved protein [Function unknown]; Region: COG3189 985002000693 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 985002000694 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 985002000695 heme-binding site [chemical binding]; other site 985002000696 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 985002000697 FAD binding pocket [chemical binding]; other site 985002000698 FAD binding motif [chemical binding]; other site 985002000699 phosphate binding motif [ion binding]; other site 985002000700 beta-alpha-beta structure motif; other site 985002000701 NAD binding pocket [chemical binding]; other site 985002000702 Heme binding pocket [chemical binding]; other site 985002000703 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 985002000704 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 985002000705 tetramer (dimer of dimers) interface [polypeptide binding]; other site 985002000706 NAD binding site [chemical binding]; other site 985002000707 dimer interface [polypeptide binding]; other site 985002000708 substrate binding site [chemical binding]; other site 985002000709 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 985002000710 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 985002000711 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 985002000712 active site turn [active] 985002000713 phosphorylation site [posttranslational modification] 985002000714 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 985002000715 active site 985002000716 tetramer interface [polypeptide binding]; other site 985002000717 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 985002000718 Mga helix-turn-helix domain; Region: Mga; pfam05043 985002000719 PRD domain; Region: PRD; pfam00874 985002000720 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 985002000721 active site 985002000722 P-loop; other site 985002000723 phosphorylation site [posttranslational modification] 985002000724 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 985002000725 active site 985002000726 phosphorylation site [posttranslational modification] 985002000727 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 985002000728 active site 985002000729 phosphorylation site [posttranslational modification] 985002000730 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 985002000731 active site 985002000732 P-loop; other site 985002000733 phosphorylation site [posttranslational modification] 985002000734 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 985002000735 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 985002000736 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 985002000737 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 985002000738 putative NAD(P) binding site [chemical binding]; other site 985002000739 catalytic Zn binding site [ion binding]; other site 985002000740 structural Zn binding site [ion binding]; other site 985002000741 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 985002000742 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 985002000743 putative NAD(P) binding site [chemical binding]; other site 985002000744 catalytic Zn binding site [ion binding]; other site 985002000745 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 985002000746 substrate binding site; other site 985002000747 dimer interface; other site 985002000748 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 985002000749 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 985002000750 putative NAD(P) binding site [chemical binding]; other site 985002000751 putative catalytic Zn binding site [ion binding]; other site 985002000752 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 985002000753 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 985002000754 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 985002000755 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 985002000756 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 985002000757 substrate binding site; other site 985002000758 dimer interface; other site 985002000759 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 985002000760 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 985002000761 putative NAD(P) binding site [chemical binding]; other site 985002000762 putative catalytic Zn binding site [ion binding]; other site 985002000763 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 985002000764 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 985002000765 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 985002000766 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 985002000767 active site 985002000768 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 985002000769 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 985002000770 GAF domain; Region: GAF; cl17456 985002000771 Histidine kinase; Region: His_kinase; pfam06580 985002000772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002000773 Mg2+ binding site [ion binding]; other site 985002000774 G-X-G motif; other site 985002000775 two-component response regulator; Provisional; Region: PRK14084 985002000776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002000777 active site 985002000778 phosphorylation site [posttranslational modification] 985002000779 intermolecular recognition site; other site 985002000780 dimerization interface [polypeptide binding]; other site 985002000781 LytTr DNA-binding domain; Region: LytTR; pfam04397 985002000782 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 985002000783 antiholin-like protein LrgB; Provisional; Region: PRK04288 985002000784 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 985002000785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 985002000786 DNA-binding site [nucleotide binding]; DNA binding site 985002000787 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 985002000788 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 985002000789 active site turn [active] 985002000790 phosphorylation site [posttranslational modification] 985002000791 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 985002000792 HPr interaction site; other site 985002000793 glycerol kinase (GK) interaction site [polypeptide binding]; other site 985002000794 active site 985002000795 phosphorylation site [posttranslational modification] 985002000796 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 985002000797 beta-galactosidase; Region: BGL; TIGR03356 985002000798 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 985002000799 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 985002000800 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 985002000801 substrate binding site [chemical binding]; other site 985002000802 dimer interface [polypeptide binding]; other site 985002000803 ATP binding site [chemical binding]; other site 985002000804 D-ribose pyranase; Provisional; Region: PRK11797 985002000805 Sugar transport protein; Region: Sugar_transport; pfam06800 985002000806 Transcriptional regulators [Transcription]; Region: PurR; COG1609 985002000807 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 985002000808 DNA binding site [nucleotide binding] 985002000809 domain linker motif; other site 985002000810 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 985002000811 dimerization interface [polypeptide binding]; other site 985002000812 ligand binding site [chemical binding]; other site 985002000813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002000814 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 985002000815 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 985002000816 active site 985002000817 Surface antigen [General function prediction only]; Region: COG3942 985002000818 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 985002000819 Peptidase family M23; Region: Peptidase_M23; pfam01551 985002000820 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 985002000821 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 985002000822 Walker A/P-loop; other site 985002000823 ATP binding site [chemical binding]; other site 985002000824 Q-loop/lid; other site 985002000825 ABC transporter signature motif; other site 985002000826 Walker B; other site 985002000827 D-loop; other site 985002000828 H-loop/switch region; other site 985002000829 Surface antigen [General function prediction only]; Region: COG3942 985002000830 CHAP domain; Region: CHAP; pfam05257 985002000831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 985002000832 Predicted membrane protein [Function unknown]; Region: COG1511 985002000833 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 985002000834 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 985002000835 heterodimer interface [polypeptide binding]; other site 985002000836 ABC-2 type transporter; Region: ABC2_membrane; cl17235 985002000837 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 985002000838 Uncharacterized small protein [Function unknown]; Region: COG5417 985002000839 Predicted membrane protein [Function unknown]; Region: COG4499 985002000840 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 985002000841 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 985002000842 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 985002000843 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 985002000844 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 985002000845 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 985002000846 Uncharacterized conserved protein [Function unknown]; Region: COG5444 985002000847 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 985002000848 Protein of unknown function, DUF600; Region: DUF600; cl04640 985002000849 Protein of unknown function, DUF600; Region: DUF600; cl04640 985002000850 Protein of unknown function, DUF600; Region: DUF600; cl04640 985002000851 Protein of unknown function, DUF600; Region: DUF600; cl04640 985002000852 conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741 985002000853 Protein of unknown function, DUF600; Region: DUF600; cl04640 985002000854 Protein of unknown function, DUF600; Region: DUF600; cl04640 985002000855 Protein of unknown function, DUF600; Region: DUF600; cl04640 985002000856 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 985002000857 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 985002000858 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 985002000859 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 985002000860 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 985002000861 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 985002000862 FtsX-like permease family; Region: FtsX; pfam02687 985002000863 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 985002000864 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 985002000865 Walker A/P-loop; other site 985002000866 ATP binding site [chemical binding]; other site 985002000867 Q-loop/lid; other site 985002000868 ABC transporter signature motif; other site 985002000869 Walker B; other site 985002000870 D-loop; other site 985002000871 H-loop/switch region; other site 985002000872 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 985002000873 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 985002000874 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 985002000875 non-specific DNA binding site [nucleotide binding]; other site 985002000876 salt bridge; other site 985002000877 sequence-specific DNA binding site [nucleotide binding]; other site 985002000878 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 985002000879 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 985002000880 substrate binding site [chemical binding]; other site 985002000881 ATP binding site [chemical binding]; other site 985002000882 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 985002000883 nucleoside transporter; Region: nupC; TIGR00804 985002000884 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 985002000885 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 985002000886 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 985002000887 putative transporter; Provisional; Region: PRK10484 985002000888 Na binding site [ion binding]; other site 985002000889 N-acetylneuraminate lyase; Provisional; Region: PRK04147 985002000890 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 985002000891 inhibitor site; inhibition site 985002000892 active site 985002000893 dimer interface [polypeptide binding]; other site 985002000894 catalytic residue [active] 985002000895 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 985002000896 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 985002000897 nucleotide binding site [chemical binding]; other site 985002000898 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 985002000899 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 985002000900 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 985002000901 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 985002000902 putative active site [active] 985002000903 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 985002000904 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 985002000905 putative active site cavity [active] 985002000906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 985002000907 Nucleoside recognition; Region: Gate; pfam07670 985002000908 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 985002000909 PGAP1-like protein; Region: PGAP1; pfam07819 985002000910 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 985002000911 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 985002000912 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 985002000913 putative active site [active] 985002000914 putative FMN binding site [chemical binding]; other site 985002000915 putative substrate binding site [chemical binding]; other site 985002000916 putative catalytic residue [active] 985002000917 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 985002000918 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 985002000919 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 985002000920 lipoyl attachment site [posttranslational modification]; other site 985002000921 Replication protein C N-terminal domain; Region: RP-C; pfam03428 985002000922 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 985002000923 putative ADP-ribose binding site [chemical binding]; other site 985002000924 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 985002000925 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 985002000926 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 985002000927 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 985002000928 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 985002000929 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 985002000930 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 985002000931 NADP binding site [chemical binding]; other site 985002000932 putative substrate binding site [chemical binding]; other site 985002000933 active site 985002000934 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 985002000935 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 985002000936 active site 985002000937 P-loop; other site 985002000938 phosphorylation site [posttranslational modification] 985002000939 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 985002000940 active site 985002000941 phosphorylation site [posttranslational modification] 985002000942 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 985002000943 HTH domain; Region: HTH_11; pfam08279 985002000944 HTH domain; Region: HTH_11; pfam08279 985002000945 PRD domain; Region: PRD; pfam00874 985002000946 PRD domain; Region: PRD; pfam00874 985002000947 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 985002000948 active site 985002000949 P-loop; other site 985002000950 phosphorylation site [posttranslational modification] 985002000951 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 985002000952 active site 985002000953 phosphorylation site [posttranslational modification] 985002000954 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 985002000955 MarR family; Region: MarR_2; pfam12802 985002000956 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 985002000957 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 985002000958 MepB protein; Region: MepB; pfam08877 985002000959 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 985002000960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002000961 putative substrate translocation pore; other site 985002000962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002000963 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 985002000964 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 985002000965 Zn binding site [ion binding]; other site 985002000966 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 985002000967 Zn binding site [ion binding]; other site 985002000968 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 985002000969 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 985002000970 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 985002000971 Predicted flavoprotein [General function prediction only]; Region: COG0431 985002000972 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 985002000973 Predicted membrane protein [Function unknown]; Region: COG2855 985002000974 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 985002000975 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 985002000976 Imelysin; Region: Peptidase_M75; pfam09375 985002000977 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 985002000978 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 985002000979 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 985002000980 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 985002000981 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 985002000982 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 985002000983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 985002000984 non-specific DNA binding site [nucleotide binding]; other site 985002000985 salt bridge; other site 985002000986 sequence-specific DNA binding site [nucleotide binding]; other site 985002000987 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 985002000988 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 985002000989 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 985002000990 Walker A/P-loop; other site 985002000991 ATP binding site [chemical binding]; other site 985002000992 Q-loop/lid; other site 985002000993 ABC transporter signature motif; other site 985002000994 Walker B; other site 985002000995 D-loop; other site 985002000996 H-loop/switch region; other site 985002000997 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 985002000998 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 985002000999 putative acyltransferase; Provisional; Region: PRK05790 985002001000 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 985002001001 dimer interface [polypeptide binding]; other site 985002001002 active site 985002001003 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 985002001004 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 985002001005 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 985002001006 THF binding site; other site 985002001007 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 985002001008 substrate binding site [chemical binding]; other site 985002001009 THF binding site; other site 985002001010 zinc-binding site [ion binding]; other site 985002001011 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 985002001012 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 985002001013 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 985002001014 FAD binding site [chemical binding]; other site 985002001015 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 985002001016 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 985002001017 homodimer interface [polypeptide binding]; other site 985002001018 substrate-cofactor binding pocket; other site 985002001019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002001020 catalytic residue [active] 985002001021 cystathionine gamma-synthase; Reviewed; Region: PRK08247 985002001022 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 985002001023 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 985002001024 catalytic residue [active] 985002001025 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 985002001026 ParB-like nuclease domain; Region: ParB; smart00470 985002001027 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 985002001028 Mechanosensitive ion channel; Region: MS_channel; pfam00924 985002001029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 985002001030 GTP-binding protein YchF; Reviewed; Region: PRK09601 985002001031 YchF GTPase; Region: YchF; cd01900 985002001032 G1 box; other site 985002001033 GTP/Mg2+ binding site [chemical binding]; other site 985002001034 Switch I region; other site 985002001035 G2 box; other site 985002001036 Switch II region; other site 985002001037 G3 box; other site 985002001038 G4 box; other site 985002001039 G5 box; other site 985002001040 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 985002001041 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 985002001042 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 985002001043 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 985002001044 dimer interface [polypeptide binding]; other site 985002001045 ssDNA binding site [nucleotide binding]; other site 985002001046 tetramer (dimer of dimers) interface [polypeptide binding]; other site 985002001047 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 985002001048 Abi-like protein; Region: Abi_2; pfam07751 985002001049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 985002001050 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 985002001051 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002001052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 985002001053 Predicted membrane protein [Function unknown]; Region: COG3212 985002001054 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 985002001055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 985002001056 non-specific DNA binding site [nucleotide binding]; other site 985002001057 salt bridge; other site 985002001058 sequence-specific DNA binding site [nucleotide binding]; other site 985002001059 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 985002001060 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 985002001061 catalytic core [active] 985002001062 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 985002001063 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 985002001064 catalytic residue [active] 985002001065 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 985002001066 catalytic residues [active] 985002001067 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 985002001068 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 985002001069 peroxiredoxin; Region: AhpC; TIGR03137 985002001070 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 985002001071 dimer interface [polypeptide binding]; other site 985002001072 decamer (pentamer of dimers) interface [polypeptide binding]; other site 985002001073 catalytic triad [active] 985002001074 peroxidatic and resolving cysteines [active] 985002001075 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 985002001076 dimer interface [polypeptide binding]; other site 985002001077 FMN binding site [chemical binding]; other site 985002001078 NADPH bind site [chemical binding]; other site 985002001079 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 985002001080 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 985002001081 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 985002001082 active site 985002001083 xanthine permease; Region: pbuX; TIGR03173 985002001084 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 985002001085 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 985002001086 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 985002001087 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 985002001088 active site 985002001089 GMP synthase; Reviewed; Region: guaA; PRK00074 985002001090 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 985002001091 AMP/PPi binding site [chemical binding]; other site 985002001092 candidate oxyanion hole; other site 985002001093 catalytic triad [active] 985002001094 potential glutamine specificity residues [chemical binding]; other site 985002001095 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 985002001096 ATP Binding subdomain [chemical binding]; other site 985002001097 Ligand Binding sites [chemical binding]; other site 985002001098 Dimerization subdomain; other site 985002001099 Terminase small subunit; Region: Terminase_2; cl01513 985002001100 Predicted membrane protein [Function unknown]; Region: COG3759 985002001101 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 985002001102 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 985002001103 NADP binding site [chemical binding]; other site 985002001104 superantigen-like protein; Reviewed; Region: PRK13037 985002001105 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 985002001106 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002001107 superantigen-like protein; Reviewed; Region: PRK13041 985002001108 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 985002001109 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002001110 superantigen-like protein; Reviewed; Region: PRK13042 985002001111 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 985002001112 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002001113 superantigen-like protein 5; Reviewed; Region: PRK13035 985002001114 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 985002001115 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002001116 superantigen-like protein 7; Reviewed; Region: PRK13346 985002001117 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 985002001118 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002001119 superantigen-like protein 5; Reviewed; Region: PRK13035 985002001120 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 985002001121 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002001122 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 985002001123 HsdM N-terminal domain; Region: HsdM_N; pfam12161 985002001124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002001125 S-adenosylmethionine binding site [chemical binding]; other site 985002001126 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 985002001127 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 985002001128 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 985002001129 superantigen-like protein; Reviewed; Region: PRK13036 985002001130 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 985002001131 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002001132 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002001133 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002001134 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002001135 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002001136 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002001137 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002001138 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002001139 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002001140 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002001141 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002001142 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002001143 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 985002001144 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 985002001145 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 985002001146 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 985002001147 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 985002001148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 985002001149 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 985002001150 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 985002001151 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 985002001152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 985002001153 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 985002001154 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 985002001155 active site 985002001156 Esterase/lipase [General function prediction only]; Region: COG1647 985002001157 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 985002001158 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 985002001159 Na2 binding site [ion binding]; other site 985002001160 putative substrate binding site 1 [chemical binding]; other site 985002001161 Na binding site 1 [ion binding]; other site 985002001162 putative substrate binding site 2 [chemical binding]; other site 985002001163 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 985002001164 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 985002001165 dimer interface [polypeptide binding]; other site 985002001166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002001167 catalytic residue [active] 985002001168 cystathionine beta-lyase; Provisional; Region: PRK07671 985002001169 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 985002001170 homodimer interface [polypeptide binding]; other site 985002001171 substrate-cofactor binding pocket; other site 985002001172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002001173 catalytic residue [active] 985002001174 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 985002001175 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 985002001176 Walker A/P-loop; other site 985002001177 ATP binding site [chemical binding]; other site 985002001178 Q-loop/lid; other site 985002001179 ABC transporter signature motif; other site 985002001180 Walker B; other site 985002001181 D-loop; other site 985002001182 H-loop/switch region; other site 985002001183 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 985002001184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002001185 dimer interface [polypeptide binding]; other site 985002001186 conserved gate region; other site 985002001187 ABC-ATPase subunit interface; other site 985002001188 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 985002001189 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 985002001190 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 985002001191 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 985002001192 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 985002001193 Surface antigen [General function prediction only]; Region: COG3942 985002001194 CHAP domain; Region: CHAP; pfam05257 985002001195 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 985002001196 nudix motif; other site 985002001197 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 985002001198 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 985002001199 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 985002001200 Transcriptional regulator [Transcription]; Region: LysR; COG0583 985002001201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 985002001202 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 985002001203 dimerization interface [polypeptide binding]; other site 985002001204 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 985002001205 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 985002001206 active site 985002001207 dimer interface [polypeptide binding]; other site 985002001208 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 985002001209 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 985002001210 active site 985002001211 FMN binding site [chemical binding]; other site 985002001212 substrate binding site [chemical binding]; other site 985002001213 3Fe-4S cluster binding site [ion binding]; other site 985002001214 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 985002001215 domain interface; other site 985002001216 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 985002001217 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 985002001218 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 985002001219 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 985002001220 active site turn [active] 985002001221 phosphorylation site [posttranslational modification] 985002001222 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 985002001223 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 985002001224 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 985002001225 Ca binding site [ion binding]; other site 985002001226 active site 985002001227 catalytic site [active] 985002001228 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 985002001229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 985002001230 DNA-binding site [nucleotide binding]; DNA binding site 985002001231 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 985002001232 UTRA domain; Region: UTRA; pfam07702 985002001233 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002001234 Coenzyme A binding pocket [chemical binding]; other site 985002001235 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 985002001236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002001237 Walker A motif; other site 985002001238 ATP binding site [chemical binding]; other site 985002001239 Walker B motif; other site 985002001240 arginine finger; other site 985002001241 hypothetical protein; Validated; Region: PRK00153 985002001242 recombination protein RecR; Reviewed; Region: recR; PRK00076 985002001243 RecR protein; Region: RecR; pfam02132 985002001244 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 985002001245 putative active site [active] 985002001246 putative metal-binding site [ion binding]; other site 985002001247 tetramer interface [polypeptide binding]; other site 985002001248 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 985002001249 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 985002001250 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 985002001251 catalytic residue [active] 985002001252 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 985002001253 thymidylate kinase; Validated; Region: tmk; PRK00698 985002001254 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 985002001255 TMP-binding site; other site 985002001256 ATP-binding site [chemical binding]; other site 985002001257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 985002001258 DNA polymerase III subunit delta'; Validated; Region: PRK08058 985002001259 DNA polymerase III subunit delta'; Validated; Region: PRK08485 985002001260 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 985002001261 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 985002001262 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 985002001263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002001264 S-adenosylmethionine binding site [chemical binding]; other site 985002001265 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 985002001266 GIY-YIG motif/motif A; other site 985002001267 putative active site [active] 985002001268 putative metal binding site [ion binding]; other site 985002001269 Predicted methyltransferases [General function prediction only]; Region: COG0313 985002001270 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 985002001271 putative SAM binding site [chemical binding]; other site 985002001272 putative homodimer interface [polypeptide binding]; other site 985002001273 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 985002001274 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 985002001275 active site 985002001276 HIGH motif; other site 985002001277 KMSKS motif; other site 985002001278 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 985002001279 tRNA binding surface [nucleotide binding]; other site 985002001280 anticodon binding site; other site 985002001281 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 985002001282 dimer interface [polypeptide binding]; other site 985002001283 putative tRNA-binding site [nucleotide binding]; other site 985002001284 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 985002001285 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 985002001286 active site 985002001287 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 985002001288 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 985002001289 putative active site [active] 985002001290 putative metal binding site [ion binding]; other site 985002001291 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 985002001292 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 985002001293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002001294 S-adenosylmethionine binding site [chemical binding]; other site 985002001295 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 985002001296 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 985002001297 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 985002001298 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 985002001299 pur operon repressor; Provisional; Region: PRK09213 985002001300 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 985002001301 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 985002001302 active site 985002001303 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 985002001304 homotrimer interaction site [polypeptide binding]; other site 985002001305 putative active site [active] 985002001306 regulatory protein SpoVG; Reviewed; Region: PRK13259 985002001307 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 985002001308 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 985002001309 Substrate binding site; other site 985002001310 Mg++ binding site; other site 985002001311 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 985002001312 active site 985002001313 substrate binding site [chemical binding]; other site 985002001314 CoA binding site [chemical binding]; other site 985002001315 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 985002001316 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 985002001317 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 985002001318 active site 985002001319 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 985002001320 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 985002001321 5S rRNA interface [nucleotide binding]; other site 985002001322 CTC domain interface [polypeptide binding]; other site 985002001323 L16 interface [polypeptide binding]; other site 985002001324 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 985002001325 putative active site [active] 985002001326 catalytic residue [active] 985002001327 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 985002001328 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 985002001329 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 985002001330 ATP binding site [chemical binding]; other site 985002001331 putative Mg++ binding site [ion binding]; other site 985002001332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 985002001333 nucleotide binding region [chemical binding]; other site 985002001334 ATP-binding site [chemical binding]; other site 985002001335 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 985002001336 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 985002001337 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 985002001338 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 985002001339 putative SAM binding site [chemical binding]; other site 985002001340 putative homodimer interface [polypeptide binding]; other site 985002001341 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 985002001342 homodimer interface [polypeptide binding]; other site 985002001343 metal binding site [ion binding]; metal-binding site 985002001344 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 985002001345 RNA binding surface [nucleotide binding]; other site 985002001346 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 985002001347 Septum formation initiator; Region: DivIC; pfam04977 985002001348 hypothetical protein; Provisional; Region: PRK08582 985002001349 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 985002001350 RNA binding site [nucleotide binding]; other site 985002001351 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 985002001352 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 985002001353 Ligand Binding Site [chemical binding]; other site 985002001354 TilS substrate C-terminal domain; Region: TilS_C; smart00977 985002001355 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 985002001356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 985002001357 active site 985002001358 FtsH Extracellular; Region: FtsH_ext; pfam06480 985002001359 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 985002001360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002001361 Walker A motif; other site 985002001362 ATP binding site [chemical binding]; other site 985002001363 Walker B motif; other site 985002001364 arginine finger; other site 985002001365 Peptidase family M41; Region: Peptidase_M41; pfam01434 985002001366 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 985002001367 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 985002001368 dimerization interface [polypeptide binding]; other site 985002001369 domain crossover interface; other site 985002001370 redox-dependent activation switch; other site 985002001371 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 985002001372 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 985002001373 dimer interface [polypeptide binding]; other site 985002001374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002001375 catalytic residue [active] 985002001376 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 985002001377 dihydropteroate synthase; Region: DHPS; TIGR01496 985002001378 substrate binding pocket [chemical binding]; other site 985002001379 dimer interface [polypeptide binding]; other site 985002001380 inhibitor binding site; inhibition site 985002001381 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 985002001382 homooctamer interface [polypeptide binding]; other site 985002001383 active site 985002001384 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 985002001385 catalytic center binding site [active] 985002001386 ATP binding site [chemical binding]; other site 985002001387 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 985002001388 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 985002001389 dimer interface [polypeptide binding]; other site 985002001390 putative anticodon binding site; other site 985002001391 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 985002001392 motif 1; other site 985002001393 active site 985002001394 motif 2; other site 985002001395 motif 3; other site 985002001396 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 985002001397 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 985002001398 DNA-binding site [nucleotide binding]; DNA binding site 985002001399 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 985002001400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002001401 homodimer interface [polypeptide binding]; other site 985002001402 catalytic residue [active] 985002001403 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 985002001404 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 985002001405 active site 985002001406 multimer interface [polypeptide binding]; other site 985002001407 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 985002001408 predicted active site [active] 985002001409 catalytic triad [active] 985002001410 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 985002001411 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 985002001412 Nucleoside recognition; Region: Gate; pfam07670 985002001413 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 985002001414 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 985002001415 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 985002001416 UvrB/uvrC motif; Region: UVR; pfam02151 985002001417 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 985002001418 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 985002001419 ADP binding site [chemical binding]; other site 985002001420 phosphagen binding site; other site 985002001421 substrate specificity loop; other site 985002001422 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 985002001423 Clp amino terminal domain; Region: Clp_N; pfam02861 985002001424 Clp amino terminal domain; Region: Clp_N; pfam02861 985002001425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002001426 Walker A motif; other site 985002001427 ATP binding site [chemical binding]; other site 985002001428 Walker B motif; other site 985002001429 arginine finger; other site 985002001430 UvrB/uvrC motif; Region: UVR; pfam02151 985002001431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002001432 Walker A motif; other site 985002001433 ATP binding site [chemical binding]; other site 985002001434 Walker B motif; other site 985002001435 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 985002001436 DNA repair protein RadA; Provisional; Region: PRK11823 985002001437 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 985002001438 Walker A motif/ATP binding site; other site 985002001439 ATP binding site [chemical binding]; other site 985002001440 Walker B motif; other site 985002001441 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 985002001442 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 985002001443 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 985002001444 putative active site [active] 985002001445 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 985002001446 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 985002001447 active site 985002001448 HIGH motif; other site 985002001449 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 985002001450 active site 985002001451 KMSKS motif; other site 985002001452 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 985002001453 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 985002001454 trimer interface [polypeptide binding]; other site 985002001455 active site 985002001456 substrate binding site [chemical binding]; other site 985002001457 CoA binding site [chemical binding]; other site 985002001458 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 985002001459 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 985002001460 active site 985002001461 HIGH motif; other site 985002001462 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 985002001463 KMSKS motif; other site 985002001464 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 985002001465 tRNA binding surface [nucleotide binding]; other site 985002001466 anticodon binding site; other site 985002001467 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 985002001468 active site 985002001469 metal binding site [ion binding]; metal-binding site 985002001470 dimerization interface [polypeptide binding]; other site 985002001471 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 985002001472 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 985002001473 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 985002001474 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 985002001475 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 985002001476 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 985002001477 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 985002001478 DNA binding residues [nucleotide binding] 985002001479 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 985002001480 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 985002001481 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 985002001482 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 985002001483 putative homodimer interface [polypeptide binding]; other site 985002001484 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 985002001485 heterodimer interface [polypeptide binding]; other site 985002001486 homodimer interface [polypeptide binding]; other site 985002001487 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 985002001488 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 985002001489 23S rRNA interface [nucleotide binding]; other site 985002001490 L7/L12 interface [polypeptide binding]; other site 985002001491 putative thiostrepton binding site; other site 985002001492 L25 interface [polypeptide binding]; other site 985002001493 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 985002001494 mRNA/rRNA interface [nucleotide binding]; other site 985002001495 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 985002001496 23S rRNA interface [nucleotide binding]; other site 985002001497 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 985002001498 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 985002001499 peripheral dimer interface [polypeptide binding]; other site 985002001500 core dimer interface [polypeptide binding]; other site 985002001501 L10 interface [polypeptide binding]; other site 985002001502 L11 interface [polypeptide binding]; other site 985002001503 putative EF-Tu interaction site [polypeptide binding]; other site 985002001504 putative EF-G interaction site [polypeptide binding]; other site 985002001505 Methyltransferase domain; Region: Methyltransf_31; pfam13847 985002001506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002001507 S-adenosylmethionine binding site [chemical binding]; other site 985002001508 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 985002001509 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 985002001510 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 985002001511 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 985002001512 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 985002001513 RPB10 interaction site [polypeptide binding]; other site 985002001514 RPB1 interaction site [polypeptide binding]; other site 985002001515 RPB11 interaction site [polypeptide binding]; other site 985002001516 RPB3 interaction site [polypeptide binding]; other site 985002001517 RPB12 interaction site [polypeptide binding]; other site 985002001518 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 985002001519 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 985002001520 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 985002001521 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 985002001522 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 985002001523 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 985002001524 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 985002001525 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 985002001526 G-loop; other site 985002001527 DNA binding site [nucleotide binding] 985002001528 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 985002001529 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 985002001530 S17 interaction site [polypeptide binding]; other site 985002001531 S8 interaction site; other site 985002001532 16S rRNA interaction site [nucleotide binding]; other site 985002001533 streptomycin interaction site [chemical binding]; other site 985002001534 23S rRNA interaction site [nucleotide binding]; other site 985002001535 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 985002001536 30S ribosomal protein S7; Validated; Region: PRK05302 985002001537 elongation factor G; Reviewed; Region: PRK00007 985002001538 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 985002001539 G1 box; other site 985002001540 putative GEF interaction site [polypeptide binding]; other site 985002001541 GTP/Mg2+ binding site [chemical binding]; other site 985002001542 Switch I region; other site 985002001543 G2 box; other site 985002001544 G3 box; other site 985002001545 Switch II region; other site 985002001546 G4 box; other site 985002001547 G5 box; other site 985002001548 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 985002001549 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 985002001550 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 985002001551 elongation factor Tu; Reviewed; Region: PRK00049 985002001552 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 985002001553 G1 box; other site 985002001554 GEF interaction site [polypeptide binding]; other site 985002001555 GTP/Mg2+ binding site [chemical binding]; other site 985002001556 Switch I region; other site 985002001557 G2 box; other site 985002001558 G3 box; other site 985002001559 Switch II region; other site 985002001560 G4 box; other site 985002001561 G5 box; other site 985002001562 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 985002001563 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 985002001564 Antibiotic Binding Site [chemical binding]; other site 985002001565 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 985002001566 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 985002001567 metal binding site [ion binding]; metal-binding site 985002001568 dimer interface [polypeptide binding]; other site 985002001569 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 985002001570 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 985002001571 substrate-cofactor binding pocket; other site 985002001572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002001573 catalytic residue [active] 985002001574 chaperone protein HchA; Provisional; Region: PRK04155 985002001575 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 985002001576 conserved cys residue [active] 985002001577 ribulokinase; Provisional; Region: PRK04123 985002001578 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 985002001579 N- and C-terminal domain interface [polypeptide binding]; other site 985002001580 active site 985002001581 MgATP binding site [chemical binding]; other site 985002001582 catalytic site [active] 985002001583 metal binding site [ion binding]; metal-binding site 985002001584 carbohydrate binding site [chemical binding]; other site 985002001585 homodimer interface [polypeptide binding]; other site 985002001586 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 985002001587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 985002001588 NAD(P) binding site [chemical binding]; other site 985002001589 active site 985002001590 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 985002001591 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 985002001592 homodimer interface [polypeptide binding]; other site 985002001593 substrate-cofactor binding pocket; other site 985002001594 catalytic residue [active] 985002001595 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 985002001596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002001597 motif II; other site 985002001598 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 985002001599 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 985002001600 Substrate-binding site [chemical binding]; other site 985002001601 Substrate specificity [chemical binding]; other site 985002001602 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 985002001603 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 985002001604 Substrate-binding site [chemical binding]; other site 985002001605 Substrate specificity [chemical binding]; other site 985002001606 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 985002001607 nucleoside/Zn binding site; other site 985002001608 dimer interface [polypeptide binding]; other site 985002001609 catalytic motif [active] 985002001610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002001611 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 985002001612 active site 985002001613 motif I; other site 985002001614 motif II; other site 985002001615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002001616 Predicted flavoprotein [General function prediction only]; Region: COG0431 985002001617 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 985002001618 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 985002001619 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 985002001620 Cna protein B-type domain; Region: Cna_B; pfam05738 985002001621 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 985002001622 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 985002001623 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 985002001624 Cna protein B-type domain; Region: Cna_B; pfam05738 985002001625 Cna protein B-type domain; Region: Cna_B; pfam05738 985002001626 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 985002001627 Cna protein B-type domain; Region: Cna_B; pfam05738 985002001628 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 985002001629 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 985002001630 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 985002001631 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 985002001632 Cna protein B-type domain; Region: Cna_B; pfam05738 985002001633 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 985002001634 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 985002001635 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 985002001636 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 985002001637 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 985002001638 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 985002001639 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 985002001640 putative GTP cyclohydrolase; Provisional; Region: PRK13674 985002001641 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 985002001642 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 985002001643 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 985002001644 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 985002001645 active site 985002001646 trimer interface [polypeptide binding]; other site 985002001647 allosteric site; other site 985002001648 active site lid [active] 985002001649 hexamer (dimer of trimers) interface [polypeptide binding]; other site 985002001650 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 985002001651 active site 985002001652 dimer interface [polypeptide binding]; other site 985002001653 magnesium binding site [ion binding]; other site 985002001654 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 985002001655 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 985002001656 tetramer interface [polypeptide binding]; other site 985002001657 active site 985002001658 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 985002001659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002001660 motif II; other site 985002001661 proline/glycine betaine transporter; Provisional; Region: PRK10642 985002001662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002001663 putative substrate translocation pore; other site 985002001664 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 985002001665 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 985002001666 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 985002001667 acyl-activating enzyme (AAE) consensus motif; other site 985002001668 acyl-activating enzyme (AAE) consensus motif; other site 985002001669 AMP binding site [chemical binding]; other site 985002001670 active site 985002001671 CoA binding site [chemical binding]; other site 985002001672 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 985002001673 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 985002001674 dimer interface [polypeptide binding]; other site 985002001675 active site 985002001676 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 985002001677 dimer interface [polypeptide binding]; other site 985002001678 substrate binding site [chemical binding]; other site 985002001679 ATP binding site [chemical binding]; other site 985002001680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 985002001681 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 985002001682 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 985002001683 ligand binding site [chemical binding]; other site 985002001684 active site 985002001685 UGI interface [polypeptide binding]; other site 985002001686 catalytic site [active] 985002001687 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 985002001688 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 985002001689 Uncharacterized conserved protein [Function unknown]; Region: COG3610 985002001690 Uncharacterized conserved protein [Function unknown]; Region: COG2966 985002001691 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 985002001692 putative heme peroxidase; Provisional; Region: PRK12276 985002001693 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 985002001694 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 985002001695 mevalonate kinase; Region: mevalon_kin; TIGR00549 985002001696 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 985002001697 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 985002001698 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 985002001699 diphosphomevalonate decarboxylase; Region: PLN02407 985002001700 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 985002001701 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 985002001702 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 985002001703 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 985002001704 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 985002001705 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 985002001706 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 985002001707 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 985002001708 Predicted transcriptional regulator [Transcription]; Region: COG1959 985002001709 Transcriptional regulator; Region: Rrf2; pfam02082 985002001710 LXG domain of WXG superfamily; Region: LXG; pfam04740 985002001711 Protein of unknown function (DUF443); Region: DUF443; pfam04276 985002001712 Protein of unknown function (DUF443); Region: DUF443; pfam04276 985002001713 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 985002001714 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 985002001715 active site 985002001716 catalytic tetrad [active] 985002001717 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 985002001718 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 985002001719 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 985002001720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002001721 Coenzyme A binding pocket [chemical binding]; other site 985002001722 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 985002001723 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 985002001724 Zn2+ binding site [ion binding]; other site 985002001725 Mg2+ binding site [ion binding]; other site 985002001726 YwhD family; Region: YwhD; pfam08741 985002001727 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 985002001728 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 985002001729 NAD binding site [chemical binding]; other site 985002001730 substrate binding site [chemical binding]; other site 985002001731 catalytic Zn binding site [ion binding]; other site 985002001732 tetramer interface [polypeptide binding]; other site 985002001733 structural Zn binding site [ion binding]; other site 985002001734 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 985002001735 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 985002001736 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 985002001737 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 985002001738 active site 985002001739 HIGH motif; other site 985002001740 KMSK motif region; other site 985002001741 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 985002001742 tRNA binding surface [nucleotide binding]; other site 985002001743 anticodon binding site; other site 985002001744 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 985002001745 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 985002001746 minor groove reading motif; other site 985002001747 helix-hairpin-helix signature motif; other site 985002001748 substrate binding pocket [chemical binding]; other site 985002001749 active site 985002001750 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 985002001751 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 985002001752 putative binding site residues; other site 985002001753 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 985002001754 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 985002001755 ABC-ATPase subunit interface; other site 985002001756 dimer interface [polypeptide binding]; other site 985002001757 putative PBP binding regions; other site 985002001758 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 985002001759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002001760 motif II; other site 985002001761 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 985002001762 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 985002001763 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 985002001764 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 985002001765 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 985002001766 Transcriptional regulators [Transcription]; Region: MarR; COG1846 985002001767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 985002001768 Protein of unknown function, DUF606; Region: DUF606; pfam04657 985002001769 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 985002001770 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 985002001771 active site 985002001772 DNA binding site [nucleotide binding] 985002001773 Int/Topo IB signature motif; other site 985002001774 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 985002001775 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 985002001776 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 985002001777 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 985002001778 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 985002001779 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 985002001780 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 985002001781 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 985002001782 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 985002001783 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 985002001784 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 985002001785 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 985002001786 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 985002001787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002001788 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 985002001789 putative substrate translocation pore; other site 985002001790 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 985002001791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002001792 motif II; other site 985002001793 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 985002001794 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 985002001795 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 985002001796 metal binding site [ion binding]; metal-binding site 985002001797 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 985002001798 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 985002001799 ABC-ATPase subunit interface; other site 985002001800 dimer interface [polypeptide binding]; other site 985002001801 putative PBP binding regions; other site 985002001802 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 985002001803 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 985002001804 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 985002001805 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 985002001806 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 985002001807 FeoA domain; Region: FeoA; cl00838 985002001808 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 985002001809 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 985002001810 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 985002001811 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 985002001812 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 985002001813 Walker A/P-loop; other site 985002001814 ATP binding site [chemical binding]; other site 985002001815 Q-loop/lid; other site 985002001816 ABC transporter signature motif; other site 985002001817 Walker B; other site 985002001818 D-loop; other site 985002001819 H-loop/switch region; other site 985002001820 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 985002001821 ABC-2 type transporter; Region: ABC2_membrane; cl17235 985002001822 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 985002001823 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 985002001824 active site 985002001825 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 985002001826 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 985002001827 active site 985002001828 nucleotide binding site [chemical binding]; other site 985002001829 HIGH motif; other site 985002001830 KMSKS motif; other site 985002001831 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 985002001832 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 985002001833 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 985002001834 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 985002001835 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 985002001836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 985002001837 Walker A/P-loop; other site 985002001838 ATP binding site [chemical binding]; other site 985002001839 Q-loop/lid; other site 985002001840 ABC transporter signature motif; other site 985002001841 Walker B; other site 985002001842 D-loop; other site 985002001843 H-loop/switch region; other site 985002001844 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 985002001845 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 985002001846 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 985002001847 Uncharacterized conserved protein [Function unknown]; Region: COG1284 985002001848 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 985002001849 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 985002001850 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 985002001851 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 985002001852 Walker A/P-loop; other site 985002001853 ATP binding site [chemical binding]; other site 985002001854 Q-loop/lid; other site 985002001855 ABC transporter signature motif; other site 985002001856 Walker B; other site 985002001857 D-loop; other site 985002001858 H-loop/switch region; other site 985002001859 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 985002001860 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 985002001861 ABC-ATPase subunit interface; other site 985002001862 dimer interface [polypeptide binding]; other site 985002001863 putative PBP binding regions; other site 985002001864 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 985002001865 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 985002001866 ABC-ATPase subunit interface; other site 985002001867 dimer interface [polypeptide binding]; other site 985002001868 putative PBP binding regions; other site 985002001869 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 985002001870 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 985002001871 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 985002001872 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 985002001873 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 985002001874 Uncharacterized membrane protein [Function unknown]; Region: COG3949 985002001875 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 985002001876 Na binding site [ion binding]; other site 985002001877 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 985002001878 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 985002001879 substrate binding pocket [chemical binding]; other site 985002001880 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 985002001881 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 985002001882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002001883 Coenzyme A binding pocket [chemical binding]; other site 985002001884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 985002001885 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 985002001886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 985002001887 NAD(P) binding site [chemical binding]; other site 985002001888 active site 985002001889 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 985002001890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002001891 active site 985002001892 phosphorylation site [posttranslational modification] 985002001893 intermolecular recognition site; other site 985002001894 dimerization interface [polypeptide binding]; other site 985002001895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 985002001896 DNA binding site [nucleotide binding] 985002001897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 985002001898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 985002001899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002001900 ATP binding site [chemical binding]; other site 985002001901 Mg2+ binding site [ion binding]; other site 985002001902 G-X-G motif; other site 985002001903 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 985002001904 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 985002001905 Walker A/P-loop; other site 985002001906 ATP binding site [chemical binding]; other site 985002001907 Q-loop/lid; other site 985002001908 ABC transporter signature motif; other site 985002001909 Walker B; other site 985002001910 D-loop; other site 985002001911 H-loop/switch region; other site 985002001912 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 985002001913 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 985002001914 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 985002001915 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 985002001916 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 985002001917 Surface antigen [General function prediction only]; Region: COG3942 985002001918 CHAP domain; Region: CHAP; pfam05257 985002001919 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 985002001920 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 985002001921 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 985002001922 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 985002001923 hypothetical protein; Provisional; Region: PRK12378 985002001924 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 985002001925 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 985002001926 Transcriptional regulator [Transcription]; Region: LysR; COG0583 985002001927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 985002001928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 985002001929 dimerization interface [polypeptide binding]; other site 985002001930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002001931 sugar efflux transporter; Region: 2A0120; TIGR00899 985002001932 putative substrate translocation pore; other site 985002001933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 985002001934 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 985002001935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002001936 Coenzyme A binding pocket [chemical binding]; other site 985002001937 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 985002001938 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 985002001939 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 985002001940 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 985002001941 hypothetical protein; Validated; Region: PRK00124 985002001942 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 985002001943 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 985002001944 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 985002001945 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 985002001946 Walker A/P-loop; other site 985002001947 ATP binding site [chemical binding]; other site 985002001948 Q-loop/lid; other site 985002001949 ABC transporter signature motif; other site 985002001950 Walker B; other site 985002001951 D-loop; other site 985002001952 H-loop/switch region; other site 985002001953 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 985002001954 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 985002001955 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 985002001956 Walker A/P-loop; other site 985002001957 ATP binding site [chemical binding]; other site 985002001958 Q-loop/lid; other site 985002001959 ABC transporter signature motif; other site 985002001960 Walker B; other site 985002001961 D-loop; other site 985002001962 H-loop/switch region; other site 985002001963 Transcriptional regulators [Transcription]; Region: MarR; COG1846 985002001964 MarR family; Region: MarR; pfam01047 985002001965 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 985002001966 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 985002001967 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 985002001968 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 985002001969 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 985002001970 active site 985002001971 catalytic tetrad [active] 985002001972 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 985002001973 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 985002001974 transmembrane helices; other site 985002001975 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 985002001976 DNA photolyase; Region: DNA_photolyase; pfam00875 985002001977 Predicted membrane protein [Function unknown]; Region: COG4330 985002001978 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 985002001979 trimer interface [polypeptide binding]; other site 985002001980 putative Zn binding site [ion binding]; other site 985002001981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002001982 putative substrate translocation pore; other site 985002001983 Major Facilitator Superfamily; Region: MFS_1; pfam07690 985002001984 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 985002001985 putative deacylase active site [active] 985002001986 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 985002001987 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 985002001988 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 985002001989 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 985002001990 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 985002001991 putative substrate binding site [chemical binding]; other site 985002001992 putative ATP binding site [chemical binding]; other site 985002001993 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 985002001994 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 985002001995 active site 985002001996 phosphorylation site [posttranslational modification] 985002001997 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 985002001998 active site 985002001999 P-loop; other site 985002002000 phosphorylation site [posttranslational modification] 985002002001 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 985002002002 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 985002002003 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 985002002004 active site 985002002005 dimer interface [polypeptide binding]; other site 985002002006 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 985002002007 Domain of unknown function DUF21; Region: DUF21; pfam01595 985002002008 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 985002002009 Transporter associated domain; Region: CorC_HlyC; pfam03471 985002002010 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 985002002011 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 985002002012 active site 985002002013 catalytic tetrad [active] 985002002014 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 985002002015 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 985002002016 Ligand binding site; other site 985002002017 Putative Catalytic site; other site 985002002018 DXD motif; other site 985002002019 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 985002002020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 985002002021 dimer interface [polypeptide binding]; other site 985002002022 phosphorylation site [posttranslational modification] 985002002023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002002024 ATP binding site [chemical binding]; other site 985002002025 Mg2+ binding site [ion binding]; other site 985002002026 G-X-G motif; other site 985002002027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 985002002028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002002029 active site 985002002030 phosphorylation site [posttranslational modification] 985002002031 intermolecular recognition site; other site 985002002032 dimerization interface [polypeptide binding]; other site 985002002033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 985002002034 DNA binding site [nucleotide binding] 985002002035 DoxX; Region: DoxX; cl17842 985002002036 Electron transfer DM13; Region: DM13; pfam10517 985002002037 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 985002002038 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 985002002039 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 985002002040 active site 985002002041 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 985002002042 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 985002002043 Ligand Binding Site [chemical binding]; other site 985002002044 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 985002002045 Glutamine amidotransferase class-I; Region: GATase; pfam00117 985002002046 glutamine binding [chemical binding]; other site 985002002047 catalytic triad [active] 985002002048 aminodeoxychorismate synthase; Provisional; Region: PRK07508 985002002049 chorismate binding enzyme; Region: Chorismate_bind; cl10555 985002002050 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 985002002051 substrate-cofactor binding pocket; other site 985002002052 homodimer interface [polypeptide binding]; other site 985002002053 Aminotransferase class IV; Region: Aminotran_4; pfam01063 985002002054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002002055 catalytic residue [active] 985002002056 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 985002002057 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 985002002058 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 985002002059 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 985002002060 Sulfatase; Region: Sulfatase; pfam00884 985002002061 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 985002002062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 985002002063 Walker A/P-loop; other site 985002002064 ATP binding site [chemical binding]; other site 985002002065 Q-loop/lid; other site 985002002066 ABC transporter signature motif; other site 985002002067 Walker B; other site 985002002068 D-loop; other site 985002002069 H-loop/switch region; other site 985002002070 ABC transporter; Region: ABC_tran_2; pfam12848 985002002071 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 985002002072 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 985002002073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 985002002074 ATP binding site [chemical binding]; other site 985002002075 putative Mg++ binding site [ion binding]; other site 985002002076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 985002002077 nucleotide binding region [chemical binding]; other site 985002002078 ATP-binding site [chemical binding]; other site 985002002079 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 985002002080 HRDC domain; Region: HRDC; pfam00570 985002002081 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 985002002082 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 985002002083 Walker A/P-loop; other site 985002002084 ATP binding site [chemical binding]; other site 985002002085 Q-loop/lid; other site 985002002086 ABC transporter signature motif; other site 985002002087 Walker B; other site 985002002088 D-loop; other site 985002002089 H-loop/switch region; other site 985002002090 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 985002002091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002002092 dimer interface [polypeptide binding]; other site 985002002093 conserved gate region; other site 985002002094 ABC-ATPase subunit interface; other site 985002002095 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 985002002096 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 985002002097 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 985002002098 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 985002002099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002002100 homodimer interface [polypeptide binding]; other site 985002002101 catalytic residue [active] 985002002102 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 985002002103 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 985002002104 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 985002002105 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 985002002106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002002107 putative substrate translocation pore; other site 985002002108 POT family; Region: PTR2; cl17359 985002002109 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 985002002110 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 985002002111 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 985002002112 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 985002002113 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 985002002114 Class I ribonucleotide reductase; Region: RNR_I; cd01679 985002002115 active site 985002002116 dimer interface [polypeptide binding]; other site 985002002117 catalytic residues [active] 985002002118 effector binding site; other site 985002002119 R2 peptide binding site; other site 985002002120 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 985002002121 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 985002002122 dimer interface [polypeptide binding]; other site 985002002123 putative radical transfer pathway; other site 985002002124 diiron center [ion binding]; other site 985002002125 tyrosyl radical; other site 985002002126 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 985002002127 ABC-ATPase subunit interface; other site 985002002128 dimer interface [polypeptide binding]; other site 985002002129 putative PBP binding regions; other site 985002002130 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 985002002131 ABC-ATPase subunit interface; other site 985002002132 dimer interface [polypeptide binding]; other site 985002002133 putative PBP binding regions; other site 985002002134 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 985002002135 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 985002002136 Walker A/P-loop; other site 985002002137 ATP binding site [chemical binding]; other site 985002002138 Q-loop/lid; other site 985002002139 ABC transporter signature motif; other site 985002002140 Walker B; other site 985002002141 D-loop; other site 985002002142 H-loop/switch region; other site 985002002143 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 985002002144 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 985002002145 putative ligand binding residues [chemical binding]; other site 985002002146 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 985002002147 CHY zinc finger; Region: zf-CHY; pfam05495 985002002148 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 985002002149 FAD binding domain; Region: FAD_binding_4; pfam01565 985002002150 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 985002002151 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 985002002152 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 985002002153 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 985002002154 peptidase T; Region: peptidase-T; TIGR01882 985002002155 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 985002002156 metal binding site [ion binding]; metal-binding site 985002002157 dimer interface [polypeptide binding]; other site 985002002158 Uncharacterized conserved protein [Function unknown]; Region: COG3610 985002002159 Uncharacterized conserved protein [Function unknown]; Region: COG2966 985002002160 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 985002002161 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 985002002162 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 985002002163 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 985002002164 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 985002002165 metal binding site [ion binding]; metal-binding site 985002002166 active site 985002002167 I-site; other site 985002002168 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 985002002169 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 985002002170 Mg++ binding site [ion binding]; other site 985002002171 putative catalytic motif [active] 985002002172 substrate binding site [chemical binding]; other site 985002002173 Uncharacterized conserved protein [Function unknown]; Region: COG1739 985002002174 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 985002002175 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 985002002176 EDD domain protein, DegV family; Region: DegV; TIGR00762 985002002177 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 985002002178 DEAD-like helicases superfamily; Region: DEXDc; smart00487 985002002179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 985002002180 ATP binding site [chemical binding]; other site 985002002181 putative Mg++ binding site [ion binding]; other site 985002002182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 985002002183 nucleotide binding region [chemical binding]; other site 985002002184 ATP-binding site [chemical binding]; other site 985002002185 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 985002002186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 985002002187 active site 985002002188 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 985002002189 30S subunit binding site; other site 985002002190 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 985002002191 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 985002002192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 985002002193 nucleotide binding region [chemical binding]; other site 985002002194 ATP-binding site [chemical binding]; other site 985002002195 SEC-C motif; Region: SEC-C; pfam02810 985002002196 peptide chain release factor 2; Validated; Region: prfB; PRK00578 985002002197 This domain is found in peptide chain release factors; Region: PCRF; smart00937 985002002198 RF-1 domain; Region: RF-1; pfam00472 985002002199 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 985002002200 Surface antigen [General function prediction only]; Region: COG3942 985002002201 CHAP domain; Region: CHAP; pfam05257 985002002202 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 985002002203 Zn2+ binding site [ion binding]; other site 985002002204 Mg2+ binding site [ion binding]; other site 985002002205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 985002002206 excinuclease ABC subunit B; Provisional; Region: PRK05298 985002002207 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 985002002208 ATP binding site [chemical binding]; other site 985002002209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 985002002210 nucleotide binding region [chemical binding]; other site 985002002211 ATP-binding site [chemical binding]; other site 985002002212 Ultra-violet resistance protein B; Region: UvrB; pfam12344 985002002213 UvrB/uvrC motif; Region: UVR; pfam02151 985002002214 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 985002002215 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 985002002216 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 985002002217 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 985002002218 HPr kinase/phosphorylase; Provisional; Region: PRK05428 985002002219 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 985002002220 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 985002002221 Hpr binding site; other site 985002002222 active site 985002002223 homohexamer subunit interaction site [polypeptide binding]; other site 985002002224 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 985002002225 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 985002002226 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 985002002227 trimer interface [polypeptide binding]; other site 985002002228 active site 985002002229 substrate binding site [chemical binding]; other site 985002002230 CoA binding site [chemical binding]; other site 985002002231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 985002002232 binding surface 985002002233 TPR motif; other site 985002002234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 985002002235 TPR motif; other site 985002002236 binding surface 985002002237 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 985002002238 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 985002002239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 985002002240 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 985002002241 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 985002002242 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 985002002243 phosphate binding site [ion binding]; other site 985002002244 dimer interface [polypeptide binding]; other site 985002002245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 985002002246 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 985002002247 Clp protease; Region: CLP_protease; pfam00574 985002002248 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 985002002249 oligomer interface [polypeptide binding]; other site 985002002250 active site residues [active] 985002002251 malate dehydrogenase; Provisional; Region: PRK13529 985002002252 Malic enzyme, N-terminal domain; Region: malic; pfam00390 985002002253 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 985002002254 NAD(P) binding site [chemical binding]; other site 985002002255 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 985002002256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 985002002257 NAD(P) binding site [chemical binding]; other site 985002002258 active site 985002002259 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 985002002260 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 985002002261 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 985002002262 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 985002002263 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 985002002264 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 985002002265 Phosphoglycerate kinase; Region: PGK; pfam00162 985002002266 substrate binding site [chemical binding]; other site 985002002267 hinge regions; other site 985002002268 ADP binding site [chemical binding]; other site 985002002269 catalytic site [active] 985002002270 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 985002002271 triosephosphate isomerase; Provisional; Region: PRK14565 985002002272 substrate binding site [chemical binding]; other site 985002002273 dimer interface [polypeptide binding]; other site 985002002274 catalytic triad [active] 985002002275 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 985002002276 phosphoglyceromutase; Provisional; Region: PRK05434 985002002277 enolase; Provisional; Region: eno; PRK00077 985002002278 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 985002002279 dimer interface [polypeptide binding]; other site 985002002280 metal binding site [ion binding]; metal-binding site 985002002281 substrate binding pocket [chemical binding]; other site 985002002282 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 985002002283 Esterase/lipase [General function prediction only]; Region: COG1647 985002002284 Baculovirus DNA helicase; Region: Baculo_helicase; pfam04735 985002002285 ribonuclease R; Region: RNase_R; TIGR02063 985002002286 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 985002002287 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 985002002288 RNB domain; Region: RNB; pfam00773 985002002289 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 985002002290 RNA binding site [nucleotide binding]; other site 985002002291 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 985002002292 SmpB-tmRNA interface; other site 985002002293 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 985002002294 Transposase; Region: HTH_Tnp_1; pfam01527 985002002295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 985002002296 putative DNA binding site [nucleotide binding]; other site 985002002297 putative Zn2+ binding site [ion binding]; other site 985002002298 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 985002002299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002002300 Coenzyme A binding pocket [chemical binding]; other site 985002002301 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 985002002302 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 985002002303 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 985002002304 Staphylococcal nuclease homologues; Region: SNc; smart00318 985002002305 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 985002002306 Catalytic site; other site 985002002307 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 985002002308 DNA-binding site [nucleotide binding]; DNA binding site 985002002309 RNA-binding motif; other site 985002002310 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 985002002311 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 985002002312 catalytic core [active] 985002002313 Lysine efflux permease [General function prediction only]; Region: COG1279 985002002314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 985002002315 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 985002002316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 985002002317 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 985002002318 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 985002002319 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 985002002320 active site 985002002321 catalytic residue [active] 985002002322 dimer interface [polypeptide binding]; other site 985002002323 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 985002002324 putative FMN binding site [chemical binding]; other site 985002002325 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 985002002326 catalytic residues [active] 985002002327 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 985002002328 ArsC family; Region: ArsC; pfam03960 985002002329 putative ArsC-like catalytic residues; other site 985002002330 putative TRX-like catalytic residues [active] 985002002331 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 985002002332 lipoyl attachment site [posttranslational modification]; other site 985002002333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 985002002334 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 985002002335 putative active site [active] 985002002336 putative metal binding site [ion binding]; other site 985002002337 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 985002002338 catalytic residues [active] 985002002339 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 985002002340 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 985002002341 Walker A/P-loop; other site 985002002342 ATP binding site [chemical binding]; other site 985002002343 Q-loop/lid; other site 985002002344 ABC transporter signature motif; other site 985002002345 Walker B; other site 985002002346 D-loop; other site 985002002347 H-loop/switch region; other site 985002002348 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 985002002349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002002350 dimer interface [polypeptide binding]; other site 985002002351 conserved gate region; other site 985002002352 ABC-ATPase subunit interface; other site 985002002353 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 985002002354 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 985002002355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 985002002356 Predicted membrane protein [Function unknown]; Region: COG2035 985002002357 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 985002002358 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 985002002359 Walker A/P-loop; other site 985002002360 ATP binding site [chemical binding]; other site 985002002361 Q-loop/lid; other site 985002002362 ABC transporter signature motif; other site 985002002363 Walker B; other site 985002002364 D-loop; other site 985002002365 H-loop/switch region; other site 985002002366 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 985002002367 FeS assembly protein SufD; Region: sufD; TIGR01981 985002002368 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 985002002369 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 985002002370 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 985002002371 catalytic residue [active] 985002002372 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 985002002373 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 985002002374 trimerization site [polypeptide binding]; other site 985002002375 active site 985002002376 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 985002002377 FeS assembly protein SufB; Region: sufB; TIGR01980 985002002378 Domain of unknown function DUF21; Region: DUF21; pfam01595 985002002379 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 985002002380 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 985002002381 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 985002002382 FMN binding site [chemical binding]; other site 985002002383 substrate binding site [chemical binding]; other site 985002002384 putative catalytic residue [active] 985002002385 Uncharacterized conserved protein [Function unknown]; Region: COG1801 985002002386 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 985002002387 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 985002002388 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 985002002389 active site 985002002390 metal binding site [ion binding]; metal-binding site 985002002391 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 985002002392 lipoyl synthase; Provisional; Region: PRK05481 985002002393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 985002002394 FeS/SAM binding site; other site 985002002395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 985002002396 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 985002002397 Uncharacterized conserved protein [Function unknown]; Region: COG2445 985002002398 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 985002002399 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002002400 active site 985002002401 motif I; other site 985002002402 motif II; other site 985002002403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002002404 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 985002002405 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 985002002406 dimerization interface [polypeptide binding]; other site 985002002407 ligand binding site [chemical binding]; other site 985002002408 NADP binding site [chemical binding]; other site 985002002409 catalytic site [active] 985002002410 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 985002002411 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 985002002412 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 985002002413 acyl-activating enzyme (AAE) consensus motif; other site 985002002414 AMP binding site [chemical binding]; other site 985002002415 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 985002002416 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 985002002417 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 985002002418 DltD N-terminal region; Region: DltD_N; pfam04915 985002002419 DltD central region; Region: DltD_M; pfam04918 985002002420 DltD C-terminal region; Region: DltD_C; pfam04914 985002002421 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 985002002422 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 985002002423 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 985002002424 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 985002002425 hypothetical protein; Provisional; Region: PRK13669 985002002426 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 985002002427 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 985002002428 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 985002002429 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 985002002430 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 985002002431 interface (dimer of trimers) [polypeptide binding]; other site 985002002432 Substrate-binding/catalytic site; other site 985002002433 Zn-binding sites [ion binding]; other site 985002002434 Predicted permease [General function prediction only]; Region: COG2056 985002002435 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 985002002436 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 985002002437 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 985002002438 CoenzymeA binding site [chemical binding]; other site 985002002439 subunit interaction site [polypeptide binding]; other site 985002002440 PHB binding site; other site 985002002441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 985002002442 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 985002002443 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 985002002444 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 985002002445 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 985002002446 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 985002002447 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 985002002448 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 985002002449 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 985002002450 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 985002002451 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 985002002452 Kinase associated protein B; Region: KapB; pfam08810 985002002453 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 985002002454 active site 985002002455 general stress protein 13; Validated; Region: PRK08059 985002002456 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 985002002457 RNA binding site [nucleotide binding]; other site 985002002458 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 985002002459 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 985002002460 putative active site [active] 985002002461 putative FMN binding site [chemical binding]; other site 985002002462 putative substrate binding site [chemical binding]; other site 985002002463 putative catalytic residue [active] 985002002464 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 985002002465 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 985002002466 inhibitor-cofactor binding pocket; inhibition site 985002002467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002002468 catalytic residue [active] 985002002469 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 985002002470 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 985002002471 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 985002002472 NAD(P) binding site [chemical binding]; other site 985002002473 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 985002002474 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 985002002475 active site 985002002476 catalytic site [active] 985002002477 metal binding site [ion binding]; metal-binding site 985002002478 argininosuccinate lyase; Provisional; Region: PRK00855 985002002479 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 985002002480 active sites [active] 985002002481 tetramer interface [polypeptide binding]; other site 985002002482 argininosuccinate synthase; Provisional; Region: PRK13820 985002002483 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 985002002484 ANP binding site [chemical binding]; other site 985002002485 Substrate Binding Site II [chemical binding]; other site 985002002486 Substrate Binding Site I [chemical binding]; other site 985002002487 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 985002002488 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 985002002489 active site 985002002490 dimer interface [polypeptide binding]; other site 985002002491 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 985002002492 dimer interface [polypeptide binding]; other site 985002002493 active site 985002002494 Uncharacterized conserved protein [Function unknown]; Region: COG0398 985002002495 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 985002002496 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 985002002497 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 985002002498 Catalytic site [active] 985002002499 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 985002002500 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 985002002501 Catalytic site [active] 985002002502 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 985002002503 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 985002002504 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 985002002505 Part of AAA domain; Region: AAA_19; pfam13245 985002002506 Family description; Region: UvrD_C_2; pfam13538 985002002507 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 985002002508 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 985002002509 hypothetical protein; Provisional; Region: PRK13673 985002002510 coenzyme A disulfide reductase; Provisional; Region: PRK13512 985002002511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 985002002512 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 985002002513 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 985002002514 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 985002002515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002002516 active site 985002002517 motif I; other site 985002002518 motif II; other site 985002002519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002002520 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 985002002521 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 985002002522 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 985002002523 catalytic triad [active] 985002002524 catalytic triad [active] 985002002525 oxyanion hole [active] 985002002526 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 985002002527 Clp amino terminal domain; Region: Clp_N; pfam02861 985002002528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002002529 Walker A motif; other site 985002002530 ATP binding site [chemical binding]; other site 985002002531 Walker B motif; other site 985002002532 arginine finger; other site 985002002533 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 985002002534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002002535 Walker A motif; other site 985002002536 ATP binding site [chemical binding]; other site 985002002537 Walker B motif; other site 985002002538 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 985002002539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 985002002540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 985002002541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 985002002542 dimerization interface [polypeptide binding]; other site 985002002543 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 985002002544 substrate binding site [chemical binding]; other site 985002002545 MAP domain; Region: MAP; pfam03642 985002002546 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 985002002547 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 985002002548 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 985002002549 dimer interface [polypeptide binding]; other site 985002002550 active site 985002002551 CoA binding pocket [chemical binding]; other site 985002002552 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 985002002553 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 985002002554 dimer interface [polypeptide binding]; other site 985002002555 active site 985002002556 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 985002002557 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 985002002558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002002559 dimer interface [polypeptide binding]; other site 985002002560 conserved gate region; other site 985002002561 putative PBP binding loops; other site 985002002562 ABC-ATPase subunit interface; other site 985002002563 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 985002002564 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 985002002565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002002566 dimer interface [polypeptide binding]; other site 985002002567 conserved gate region; other site 985002002568 putative PBP binding loops; other site 985002002569 ABC-ATPase subunit interface; other site 985002002570 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 985002002571 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 985002002572 Walker A/P-loop; other site 985002002573 ATP binding site [chemical binding]; other site 985002002574 Q-loop/lid; other site 985002002575 ABC transporter signature motif; other site 985002002576 Walker B; other site 985002002577 D-loop; other site 985002002578 H-loop/switch region; other site 985002002579 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 985002002580 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 985002002581 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 985002002582 Walker A/P-loop; other site 985002002583 ATP binding site [chemical binding]; other site 985002002584 Q-loop/lid; other site 985002002585 ABC transporter signature motif; other site 985002002586 Walker B; other site 985002002587 D-loop; other site 985002002588 H-loop/switch region; other site 985002002589 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 985002002590 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 985002002591 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 985002002592 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 985002002593 peptide binding site [polypeptide binding]; other site 985002002594 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 985002002595 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 985002002596 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 985002002597 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 985002002598 Walker A/P-loop; other site 985002002599 ATP binding site [chemical binding]; other site 985002002600 Q-loop/lid; other site 985002002601 ABC transporter signature motif; other site 985002002602 Walker B; other site 985002002603 D-loop; other site 985002002604 H-loop/switch region; other site 985002002605 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 985002002606 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 985002002607 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 985002002608 Walker A/P-loop; other site 985002002609 ATP binding site [chemical binding]; other site 985002002610 Q-loop/lid; other site 985002002611 ABC transporter signature motif; other site 985002002612 Walker B; other site 985002002613 D-loop; other site 985002002614 H-loop/switch region; other site 985002002615 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 985002002616 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 985002002617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002002618 dimer interface [polypeptide binding]; other site 985002002619 conserved gate region; other site 985002002620 putative PBP binding loops; other site 985002002621 ABC-ATPase subunit interface; other site 985002002622 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 985002002623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002002624 dimer interface [polypeptide binding]; other site 985002002625 conserved gate region; other site 985002002626 putative PBP binding loops; other site 985002002627 ABC-ATPase subunit interface; other site 985002002628 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 985002002629 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 985002002630 active site 985002002631 HIGH motif; other site 985002002632 dimer interface [polypeptide binding]; other site 985002002633 KMSKS motif; other site 985002002634 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 985002002635 ArsC family; Region: ArsC; pfam03960 985002002636 putative catalytic residues [active] 985002002637 thiol/disulfide switch; other site 985002002638 adaptor protein; Provisional; Region: PRK02315 985002002639 Competence protein CoiA-like family; Region: CoiA; cl11541 985002002640 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 985002002641 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 985002002642 active site 985002002643 Zn binding site [ion binding]; other site 985002002644 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 985002002645 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 985002002646 catalytic residues [active] 985002002647 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 985002002648 apolar tunnel; other site 985002002649 heme binding site [chemical binding]; other site 985002002650 dimerization interface [polypeptide binding]; other site 985002002651 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 985002002652 putative active site [active] 985002002653 putative metal binding residues [ion binding]; other site 985002002654 signature motif; other site 985002002655 putative triphosphate binding site [ion binding]; other site 985002002656 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 985002002657 synthetase active site [active] 985002002658 NTP binding site [chemical binding]; other site 985002002659 metal binding site [ion binding]; metal-binding site 985002002660 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 985002002661 ATP-NAD kinase; Region: NAD_kinase; pfam01513 985002002662 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 985002002663 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 985002002664 active site 985002002665 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 985002002666 MgtE intracellular N domain; Region: MgtE_N; smart00924 985002002667 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 985002002668 Divalent cation transporter; Region: MgtE; pfam01769 985002002669 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 985002002670 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 985002002671 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 985002002672 TrkA-N domain; Region: TrkA_N; pfam02254 985002002673 TrkA-C domain; Region: TrkA_C; pfam02080 985002002674 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 985002002675 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 985002002676 NAD binding site [chemical binding]; other site 985002002677 homotetramer interface [polypeptide binding]; other site 985002002678 homodimer interface [polypeptide binding]; other site 985002002679 substrate binding site [chemical binding]; other site 985002002680 active site 985002002681 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 985002002682 Domain of unknown function DUF20; Region: UPF0118; pfam01594 985002002683 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 985002002684 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 985002002685 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 985002002686 Putative esterase; Region: Esterase; pfam00756 985002002687 hypothetical protein; Provisional; Region: PRK13679 985002002688 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 985002002689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 985002002690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002002691 putative substrate translocation pore; other site 985002002692 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 985002002693 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 985002002694 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 985002002695 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 985002002696 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 985002002697 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 985002002698 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 985002002699 YueH-like protein; Region: YueH; pfam14166 985002002700 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 985002002701 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 985002002702 G1 box; other site 985002002703 putative GEF interaction site [polypeptide binding]; other site 985002002704 GTP/Mg2+ binding site [chemical binding]; other site 985002002705 Switch I region; other site 985002002706 G2 box; other site 985002002707 G3 box; other site 985002002708 Switch II region; other site 985002002709 G4 box; other site 985002002710 G5 box; other site 985002002711 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 985002002712 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 985002002713 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 985002002714 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 985002002715 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 985002002716 protein binding site [polypeptide binding]; other site 985002002717 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 985002002718 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 985002002719 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 985002002720 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 985002002721 active site 985002002722 metal binding site [ion binding]; metal-binding site 985002002723 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 985002002724 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 985002002725 IDEAL domain; Region: IDEAL; pfam08858 985002002726 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 985002002727 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 985002002728 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 985002002729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 985002002730 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683 985002002731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 985002002732 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 985002002733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 985002002734 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 985002002735 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 985002002736 Walker A/P-loop; other site 985002002737 ATP binding site [chemical binding]; other site 985002002738 Q-loop/lid; other site 985002002739 ABC transporter signature motif; other site 985002002740 Walker B; other site 985002002741 D-loop; other site 985002002742 H-loop/switch region; other site 985002002743 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 985002002744 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 985002002745 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 985002002746 Predicted membrane protein [Function unknown]; Region: COG2259 985002002747 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 985002002748 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 985002002749 siderophore binding site; other site 985002002750 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 985002002751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002002752 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 985002002753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 985002002754 Coenzyme A binding pocket [chemical binding]; other site 985002002755 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 985002002756 UbiA prenyltransferase family; Region: UbiA; pfam01040 985002002757 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 985002002758 isochorismate synthases; Region: isochor_syn; TIGR00543 985002002759 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 985002002760 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 985002002761 dimer interface [polypeptide binding]; other site 985002002762 tetramer interface [polypeptide binding]; other site 985002002763 PYR/PP interface [polypeptide binding]; other site 985002002764 TPP binding site [chemical binding]; other site 985002002765 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 985002002766 TPP-binding site; other site 985002002767 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 985002002768 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 985002002769 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 985002002770 substrate binding site [chemical binding]; other site 985002002771 oxyanion hole (OAH) forming residues; other site 985002002772 trimer interface [polypeptide binding]; other site 985002002773 Staphostatin B; Region: Staphostatin_B; pfam09023 985002002774 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 985002002775 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 985002002776 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 985002002777 aminotransferase A; Validated; Region: PRK07683 985002002778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 985002002779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002002780 homodimer interface [polypeptide binding]; other site 985002002781 catalytic residue [active] 985002002782 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 985002002783 Acyltransferase family; Region: Acyl_transf_3; pfam01757 985002002784 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 985002002785 MarR family; Region: MarR; pfam01047 985002002786 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 985002002787 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 985002002788 amidase catalytic site [active] 985002002789 Zn binding residues [ion binding]; other site 985002002790 substrate binding site [chemical binding]; other site 985002002791 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 985002002792 Lysozyme subfamily 2; Region: LYZ2; smart00047 985002002793 Autoinducer synthetase; Region: Autoind_synth; cl17404 985002002794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002002795 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 985002002796 Coenzyme A binding pocket [chemical binding]; other site 985002002797 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 985002002798 Transcriptional regulator [Transcription]; Region: LytR; COG1316 985002002799 Beta-lactamase; Region: Beta-lactamase; pfam00144 985002002800 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 985002002801 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 985002002802 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 985002002803 Subunit I/III interface [polypeptide binding]; other site 985002002804 Subunit III/IV interface [polypeptide binding]; other site 985002002805 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 985002002806 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 985002002807 D-pathway; other site 985002002808 Putative ubiquinol binding site [chemical binding]; other site 985002002809 Low-spin heme (heme b) binding site [chemical binding]; other site 985002002810 Putative water exit pathway; other site 985002002811 Binuclear center (heme o3/CuB) [ion binding]; other site 985002002812 K-pathway; other site 985002002813 Putative proton exit pathway; other site 985002002814 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 985002002815 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 985002002816 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 985002002817 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 985002002818 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 985002002819 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 985002002820 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 985002002821 homodimer interface [polypeptide binding]; other site 985002002822 NADP binding site [chemical binding]; other site 985002002823 substrate binding site [chemical binding]; other site 985002002824 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 985002002825 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 985002002826 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 985002002827 NAD binding site [chemical binding]; other site 985002002828 ATP-grasp domain; Region: ATP-grasp; pfam02222 985002002829 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 985002002830 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 985002002831 ATP binding site [chemical binding]; other site 985002002832 active site 985002002833 substrate binding site [chemical binding]; other site 985002002834 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 985002002835 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 985002002836 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 985002002837 putative active site [active] 985002002838 catalytic triad [active] 985002002839 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 985002002840 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 985002002841 dimerization interface [polypeptide binding]; other site 985002002842 ATP binding site [chemical binding]; other site 985002002843 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 985002002844 dimerization interface [polypeptide binding]; other site 985002002845 ATP binding site [chemical binding]; other site 985002002846 amidophosphoribosyltransferase; Provisional; Region: PRK07272 985002002847 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 985002002848 active site 985002002849 tetramer interface [polypeptide binding]; other site 985002002850 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 985002002851 active site 985002002852 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 985002002853 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 985002002854 dimerization interface [polypeptide binding]; other site 985002002855 putative ATP binding site [chemical binding]; other site 985002002856 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 985002002857 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 985002002858 active site 985002002859 substrate binding site [chemical binding]; other site 985002002860 cosubstrate binding site; other site 985002002861 catalytic site [active] 985002002862 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 985002002863 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 985002002864 purine monophosphate binding site [chemical binding]; other site 985002002865 dimer interface [polypeptide binding]; other site 985002002866 putative catalytic residues [active] 985002002867 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 985002002868 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 985002002869 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 985002002870 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 985002002871 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 985002002872 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 985002002873 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 985002002874 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 985002002875 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 985002002876 Walker A/P-loop; other site 985002002877 ATP binding site [chemical binding]; other site 985002002878 Q-loop/lid; other site 985002002879 ABC transporter signature motif; other site 985002002880 Walker B; other site 985002002881 D-loop; other site 985002002882 H-loop/switch region; other site 985002002883 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 985002002884 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 985002002885 Walker A/P-loop; other site 985002002886 ATP binding site [chemical binding]; other site 985002002887 Q-loop/lid; other site 985002002888 ABC transporter signature motif; other site 985002002889 Walker B; other site 985002002890 D-loop; other site 985002002891 H-loop/switch region; other site 985002002892 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 985002002893 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 985002002894 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 985002002895 putative RNA binding site [nucleotide binding]; other site 985002002896 Methyltransferase domain; Region: Methyltransf_26; pfam13659 985002002897 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 985002002898 dimerization domain swap beta strand [polypeptide binding]; other site 985002002899 regulatory protein interface [polypeptide binding]; other site 985002002900 active site 985002002901 regulatory phosphorylation site [posttranslational modification]; other site 985002002902 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 985002002903 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 985002002904 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 985002002905 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 985002002906 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 985002002907 catalytic residues [active] 985002002908 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 985002002909 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 985002002910 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 985002002911 TrkA-N domain; Region: TrkA_N; pfam02254 985002002912 TrkA-C domain; Region: TrkA_C; pfam02080 985002002913 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 985002002914 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 985002002915 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 985002002916 hypothetical protein; Provisional; Region: PRK13667 985002002917 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 985002002918 active site 985002002919 catalytic residues [active] 985002002920 metal binding site [ion binding]; metal-binding site 985002002921 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 985002002922 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 985002002923 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 985002002924 TPP-binding site [chemical binding]; other site 985002002925 tetramer interface [polypeptide binding]; other site 985002002926 heterodimer interface [polypeptide binding]; other site 985002002927 phosphorylation loop region [posttranslational modification] 985002002928 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 985002002929 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 985002002930 alpha subunit interface [polypeptide binding]; other site 985002002931 TPP binding site [chemical binding]; other site 985002002932 heterodimer interface [polypeptide binding]; other site 985002002933 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 985002002934 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 985002002935 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 985002002936 E3 interaction surface; other site 985002002937 lipoyl attachment site [posttranslational modification]; other site 985002002938 e3 binding domain; Region: E3_binding; pfam02817 985002002939 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 985002002940 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 985002002941 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 985002002942 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 985002002943 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 985002002944 hypothetical protein; Provisional; Region: PRK04387 985002002945 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 985002002946 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 985002002947 non-specific DNA binding site [nucleotide binding]; other site 985002002948 salt bridge; other site 985002002949 sequence-specific DNA binding site [nucleotide binding]; other site 985002002950 Cupin domain; Region: Cupin_2; pfam07883 985002002951 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 985002002952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 985002002953 Walker A/P-loop; other site 985002002954 ATP binding site [chemical binding]; other site 985002002955 Q-loop/lid; other site 985002002956 ABC transporter signature motif; other site 985002002957 Walker B; other site 985002002958 D-loop; other site 985002002959 H-loop/switch region; other site 985002002960 TOBE domain; Region: TOBE_2; pfam08402 985002002961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 985002002962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002002963 putative PBP binding loops; other site 985002002964 dimer interface [polypeptide binding]; other site 985002002965 ABC-ATPase subunit interface; other site 985002002966 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 985002002967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002002968 dimer interface [polypeptide binding]; other site 985002002969 conserved gate region; other site 985002002970 putative PBP binding loops; other site 985002002971 ABC-ATPase subunit interface; other site 985002002972 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 985002002973 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 985002002974 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 985002002975 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 985002002976 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 985002002977 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 985002002978 manganese transport protein MntH; Reviewed; Region: PRK00701 985002002979 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 985002002980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 985002002981 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 985002002982 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 985002002983 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 985002002984 active site 985002002985 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 985002002986 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 985002002987 G1 box; other site 985002002988 putative GEF interaction site [polypeptide binding]; other site 985002002989 GTP/Mg2+ binding site [chemical binding]; other site 985002002990 Switch I region; other site 985002002991 G2 box; other site 985002002992 G3 box; other site 985002002993 Switch II region; other site 985002002994 G4 box; other site 985002002995 G5 box; other site 985002002996 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 985002002997 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 985002002998 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 985002002999 hypothetical protein; Provisional; Region: PRK13666 985002003000 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 985002003001 pyruvate carboxylase; Reviewed; Region: PRK12999 985002003002 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 985002003003 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 985002003004 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 985002003005 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 985002003006 active site 985002003007 catalytic residues [active] 985002003008 metal binding site [ion binding]; metal-binding site 985002003009 homodimer binding site [polypeptide binding]; other site 985002003010 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 985002003011 carboxyltransferase (CT) interaction site; other site 985002003012 biotinylation site [posttranslational modification]; other site 985002003013 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 985002003014 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 985002003015 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 985002003016 UbiA prenyltransferase family; Region: UbiA; pfam01040 985002003017 Predicted membrane protein [Function unknown]; Region: COG2322 985002003018 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 985002003019 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 985002003020 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 985002003021 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 985002003022 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 985002003023 putative active site [active] 985002003024 catalytic site [active] 985002003025 putative metal binding site [ion binding]; other site 985002003026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 985002003027 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 985002003028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002003029 S-adenosylmethionine binding site [chemical binding]; other site 985002003030 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 985002003031 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 985002003032 active site 985002003033 (T/H)XGH motif; other site 985002003034 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 985002003035 hypothetical protein; Provisional; Region: PRK13670 985002003036 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 985002003037 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 985002003038 heme uptake protein IsdB; Region: IsdB; TIGR03657 985002003039 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 985002003040 NEAr Transporter domain; Region: NEAT; smart00725 985002003041 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 985002003042 heme-binding site [chemical binding]; other site 985002003043 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 985002003044 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 985002003045 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 985002003046 heme-binding site [chemical binding]; other site 985002003047 heme uptake protein IsdC; Region: IsdC; TIGR03656 985002003048 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 985002003049 heme-binding site [chemical binding]; other site 985002003050 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 985002003051 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 985002003052 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 985002003053 intersubunit interface [polypeptide binding]; other site 985002003054 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 985002003055 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 985002003056 ABC-ATPase subunit interface; other site 985002003057 dimer interface [polypeptide binding]; other site 985002003058 putative PBP binding regions; other site 985002003059 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 985002003060 active site 985002003061 catalytic site [active] 985002003062 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 985002003063 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 985002003064 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 985002003065 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 985002003066 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 985002003067 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 985002003068 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 985002003069 dimer interface [polypeptide binding]; other site 985002003070 motif 1; other site 985002003071 active site 985002003072 motif 2; other site 985002003073 motif 3; other site 985002003074 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 985002003075 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 985002003076 putative tRNA-binding site [nucleotide binding]; other site 985002003077 B3/4 domain; Region: B3_4; pfam03483 985002003078 tRNA synthetase B5 domain; Region: B5; smart00874 985002003079 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 985002003080 dimer interface [polypeptide binding]; other site 985002003081 motif 1; other site 985002003082 motif 3; other site 985002003083 motif 2; other site 985002003084 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 985002003085 ribonuclease HIII; Provisional; Region: PRK00996 985002003086 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 985002003087 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 985002003088 RNA/DNA hybrid binding site [nucleotide binding]; other site 985002003089 active site 985002003090 Cell division protein ZapA; Region: ZapA; cl01146 985002003091 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 985002003092 Colicin V production protein; Region: Colicin_V; pfam02674 985002003093 hypothetical protein; Provisional; Region: PRK08609 985002003094 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 985002003095 active site 985002003096 primer binding site [nucleotide binding]; other site 985002003097 NTP binding site [chemical binding]; other site 985002003098 metal binding triad [ion binding]; metal-binding site 985002003099 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 985002003100 active site 985002003101 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 985002003102 MutS domain III; Region: MutS_III; pfam05192 985002003103 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 985002003104 Walker A/P-loop; other site 985002003105 ATP binding site [chemical binding]; other site 985002003106 Q-loop/lid; other site 985002003107 ABC transporter signature motif; other site 985002003108 Walker B; other site 985002003109 D-loop; other site 985002003110 H-loop/switch region; other site 985002003111 Smr domain; Region: Smr; pfam01713 985002003112 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 985002003113 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 985002003114 catalytic residues [active] 985002003115 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 985002003116 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 985002003117 GIY-YIG motif/motif A; other site 985002003118 active site 985002003119 catalytic site [active] 985002003120 putative DNA binding site [nucleotide binding]; other site 985002003121 metal binding site [ion binding]; metal-binding site 985002003122 UvrB/uvrC motif; Region: UVR; pfam02151 985002003123 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 985002003124 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 985002003125 putative Iron-sulfur protein interface [polypeptide binding]; other site 985002003126 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 985002003127 proximal heme binding site [chemical binding]; other site 985002003128 distal heme binding site [chemical binding]; other site 985002003129 putative dimer interface [polypeptide binding]; other site 985002003130 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 985002003131 L-aspartate oxidase; Provisional; Region: PRK06175 985002003132 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 985002003133 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 985002003134 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 985002003135 glutamate racemase; Provisional; Region: PRK00865 985002003136 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 985002003137 active site 985002003138 dimerization interface [polypeptide binding]; other site 985002003139 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 985002003140 active site 985002003141 metal binding site [ion binding]; metal-binding site 985002003142 homotetramer interface [polypeptide binding]; other site 985002003143 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 985002003144 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 985002003145 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 985002003146 beta-channel forming cytolysin; Region: hlyII; TIGR01002 985002003147 superantigen-like protein; Reviewed; Region: PRK13350 985002003148 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002003149 superantigen-like protein; Reviewed; Region: PRK13349 985002003150 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002003151 superantigen-like protein; Reviewed; Region: PRK13043 985002003152 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002003153 ornithine carbamoyltransferase; Provisional; Region: PRK04284 985002003154 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 985002003155 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 985002003156 carbamate kinase; Reviewed; Region: PRK12686 985002003157 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 985002003158 putative substrate binding site [chemical binding]; other site 985002003159 nucleotide binding site [chemical binding]; other site 985002003160 nucleotide binding site [chemical binding]; other site 985002003161 homodimer interface [polypeptide binding]; other site 985002003162 Predicted membrane protein [Function unknown]; Region: COG1288 985002003163 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 985002003164 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 985002003165 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 985002003166 gating phenylalanine in ion channel; other site 985002003167 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 985002003168 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 985002003169 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 985002003170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002003171 motif II; other site 985002003172 hypothetical protein; Provisional; Region: PRK13688 985002003173 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 985002003174 Coenzyme A binding pocket [chemical binding]; other site 985002003175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 985002003176 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 985002003177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 985002003178 MraZ protein; Region: MraZ; pfam02381 985002003179 MraZ protein; Region: MraZ; pfam02381 985002003180 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 985002003181 MraW methylase family; Region: Methyltransf_5; pfam01795 985002003182 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 985002003183 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 985002003184 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 985002003185 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 985002003186 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 985002003187 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 985002003188 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 985002003189 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 985002003190 Mg++ binding site [ion binding]; other site 985002003191 putative catalytic motif [active] 985002003192 putative substrate binding site [chemical binding]; other site 985002003193 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 985002003194 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 985002003195 NAD binding site [chemical binding]; other site 985002003196 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 985002003197 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 985002003198 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 985002003199 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 985002003200 Cell division protein FtsQ; Region: FtsQ; pfam03799 985002003201 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 985002003202 Cell division protein FtsA; Region: FtsA; smart00842 985002003203 Cell division protein FtsA; Region: FtsA; pfam14450 985002003204 cell division protein FtsZ; Validated; Region: PRK09330 985002003205 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 985002003206 nucleotide binding site [chemical binding]; other site 985002003207 SulA interaction site; other site 985002003208 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 985002003209 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 985002003210 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 985002003211 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 985002003212 catalytic residue [active] 985002003213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 985002003214 YGGT family; Region: YGGT; pfam02325 985002003215 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 985002003216 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 985002003217 RNA binding surface [nucleotide binding]; other site 985002003218 DivIVA protein; Region: DivIVA; pfam05103 985002003219 DivIVA domain; Region: DivI1A_domain; TIGR03544 985002003220 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 985002003221 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 985002003222 HIGH motif; other site 985002003223 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 985002003224 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 985002003225 active site 985002003226 KMSKS motif; other site 985002003227 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 985002003228 tRNA binding surface [nucleotide binding]; other site 985002003229 anticodon binding site; other site 985002003230 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 985002003231 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 985002003232 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 985002003233 active site 985002003234 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 985002003235 lipoprotein signal peptidase; Provisional; Region: PRK14787 985002003236 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 985002003237 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 985002003238 RNA binding surface [nucleotide binding]; other site 985002003239 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 985002003240 active site 985002003241 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 985002003242 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 985002003243 active site 985002003244 uracil transporter; Provisional; Region: PRK10720 985002003245 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 985002003246 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 985002003247 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 985002003248 dihydroorotase; Validated; Region: pyrC; PRK09357 985002003249 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 985002003250 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 985002003251 active site 985002003252 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 985002003253 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 985002003254 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 985002003255 catalytic site [active] 985002003256 subunit interface [polypeptide binding]; other site 985002003257 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 985002003258 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 985002003259 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 985002003260 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 985002003261 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 985002003262 ATP-grasp domain; Region: ATP-grasp_4; cl17255 985002003263 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 985002003264 IMP binding site; other site 985002003265 dimer interface [polypeptide binding]; other site 985002003266 interdomain contacts; other site 985002003267 partial ornithine binding site; other site 985002003268 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 985002003269 active site 985002003270 dimer interface [polypeptide binding]; other site 985002003271 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 985002003272 active site 985002003273 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 985002003274 dimer interface [polypeptide binding]; other site 985002003275 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 985002003276 Domain of unknown function (DUF814); Region: DUF814; pfam05670 985002003277 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 985002003278 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 985002003279 catalytic site [active] 985002003280 G-X2-G-X-G-K; other site 985002003281 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 985002003282 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 985002003283 Flavoprotein; Region: Flavoprotein; pfam02441 985002003284 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 985002003285 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 985002003286 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 985002003287 ATP binding site [chemical binding]; other site 985002003288 putative Mg++ binding site [ion binding]; other site 985002003289 helicase superfamily c-terminal domain; Region: HELICc; smart00490 985002003290 nucleotide binding region [chemical binding]; other site 985002003291 ATP-binding site [chemical binding]; other site 985002003292 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 985002003293 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 985002003294 active site 985002003295 catalytic residues [active] 985002003296 metal binding site [ion binding]; metal-binding site 985002003297 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 985002003298 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 985002003299 putative active site [active] 985002003300 substrate binding site [chemical binding]; other site 985002003301 putative cosubstrate binding site; other site 985002003302 catalytic site [active] 985002003303 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 985002003304 substrate binding site [chemical binding]; other site 985002003305 16S rRNA methyltransferase B; Provisional; Region: PRK14902 985002003306 NusB family; Region: NusB; pfam01029 985002003307 putative RNA binding site [nucleotide binding]; other site 985002003308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002003309 S-adenosylmethionine binding site [chemical binding]; other site 985002003310 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 985002003311 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 985002003312 FeS/SAM binding site; other site 985002003313 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 985002003314 Protein phosphatase 2C; Region: PP2C; pfam00481 985002003315 active site 985002003316 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 985002003317 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 985002003318 active site 985002003319 ATP binding site [chemical binding]; other site 985002003320 substrate binding site [chemical binding]; other site 985002003321 activation loop (A-loop); other site 985002003322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 985002003323 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 985002003324 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 985002003325 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 985002003326 Predicted GTPases [General function prediction only]; Region: COG1162 985002003327 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 985002003328 RNA binding site [nucleotide binding]; other site 985002003329 homodimer interface [polypeptide binding]; other site 985002003330 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 985002003331 GTPase/Zn-binding domain interface [polypeptide binding]; other site 985002003332 GTP/Mg2+ binding site [chemical binding]; other site 985002003333 G4 box; other site 985002003334 G5 box; other site 985002003335 G1 box; other site 985002003336 Switch I region; other site 985002003337 G2 box; other site 985002003338 G3 box; other site 985002003339 Switch II region; other site 985002003340 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 985002003341 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 985002003342 substrate binding site [chemical binding]; other site 985002003343 hexamer interface [polypeptide binding]; other site 985002003344 metal binding site [ion binding]; metal-binding site 985002003345 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 985002003346 Thiamine pyrophosphokinase; Region: TPK; cd07995 985002003347 active site 985002003348 dimerization interface [polypeptide binding]; other site 985002003349 thiamine binding site [chemical binding]; other site 985002003350 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 985002003351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 985002003352 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 985002003353 DAK2 domain; Region: Dak2; pfam02734 985002003354 RimM N-terminal domain; Region: RimM; pfam01782 985002003355 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 985002003356 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 985002003357 ssDNA binding site; other site 985002003358 generic binding surface II; other site 985002003359 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 985002003360 ATP binding site [chemical binding]; other site 985002003361 putative Mg++ binding site [ion binding]; other site 985002003362 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 985002003363 nucleotide binding region [chemical binding]; other site 985002003364 ATP-binding site [chemical binding]; other site 985002003365 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 985002003366 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 985002003367 active site 2 [active] 985002003368 active site 1 [active] 985002003369 putative phosphate acyltransferase; Provisional; Region: PRK05331 985002003370 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 985002003371 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 985002003372 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 985002003373 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 985002003374 NAD(P) binding site [chemical binding]; other site 985002003375 homotetramer interface [polypeptide binding]; other site 985002003376 homodimer interface [polypeptide binding]; other site 985002003377 active site 985002003378 acyl carrier protein; Provisional; Region: acpP; PRK00982 985002003379 ribonuclease III; Reviewed; Region: rnc; PRK00102 985002003380 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 985002003381 dimerization interface [polypeptide binding]; other site 985002003382 active site 985002003383 metal binding site [ion binding]; metal-binding site 985002003384 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 985002003385 dsRNA binding site [nucleotide binding]; other site 985002003386 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 985002003387 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 985002003388 Walker A/P-loop; other site 985002003389 ATP binding site [chemical binding]; other site 985002003390 Q-loop/lid; other site 985002003391 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 985002003392 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 985002003393 ABC transporter signature motif; other site 985002003394 Walker B; other site 985002003395 D-loop; other site 985002003396 H-loop/switch region; other site 985002003397 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 985002003398 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 985002003399 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 985002003400 P loop; other site 985002003401 GTP binding site [chemical binding]; other site 985002003402 putative DNA-binding protein; Validated; Region: PRK00118 985002003403 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 985002003404 signal recognition particle protein; Provisional; Region: PRK10867 985002003405 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 985002003406 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 985002003407 P loop; other site 985002003408 GTP binding site [chemical binding]; other site 985002003409 Signal peptide binding domain; Region: SRP_SPB; pfam02978 985002003410 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 985002003411 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 985002003412 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 985002003413 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 985002003414 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 985002003415 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 985002003416 RimM N-terminal domain; Region: RimM; pfam01782 985002003417 PRC-barrel domain; Region: PRC; pfam05239 985002003418 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 985002003419 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 985002003420 Predicted membrane protein [Function unknown]; Region: COG4485 985002003421 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 985002003422 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 985002003423 GTP/Mg2+ binding site [chemical binding]; other site 985002003424 G4 box; other site 985002003425 G5 box; other site 985002003426 G1 box; other site 985002003427 Switch I region; other site 985002003428 G2 box; other site 985002003429 G3 box; other site 985002003430 Switch II region; other site 985002003431 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 985002003432 RNA/DNA hybrid binding site [nucleotide binding]; other site 985002003433 active site 985002003434 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 985002003435 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 985002003436 CoA-ligase; Region: Ligase_CoA; pfam00549 985002003437 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 985002003438 CoA binding domain; Region: CoA_binding; pfam02629 985002003439 CoA-ligase; Region: Ligase_CoA; pfam00549 985002003440 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 985002003441 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 985002003442 CHAP domain; Region: CHAP; pfam05257 985002003443 FemAB family; Region: FemAB; pfam02388 985002003444 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 985002003445 DNA protecting protein DprA; Region: dprA; TIGR00732 985002003446 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 985002003447 DNA topoisomerase I; Validated; Region: PRK05582 985002003448 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 985002003449 active site 985002003450 interdomain interaction site; other site 985002003451 putative metal-binding site [ion binding]; other site 985002003452 nucleotide binding site [chemical binding]; other site 985002003453 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 985002003454 domain I; other site 985002003455 DNA binding groove [nucleotide binding] 985002003456 phosphate binding site [ion binding]; other site 985002003457 domain II; other site 985002003458 domain III; other site 985002003459 nucleotide binding site [chemical binding]; other site 985002003460 catalytic site [active] 985002003461 domain IV; other site 985002003462 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 985002003463 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 985002003464 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 985002003465 Glucose inhibited division protein A; Region: GIDA; pfam01134 985002003466 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 985002003467 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 985002003468 active site 985002003469 DNA binding site [nucleotide binding] 985002003470 Int/Topo IB signature motif; other site 985002003471 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 985002003472 active site 985002003473 HslU subunit interaction site [polypeptide binding]; other site 985002003474 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 985002003475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002003476 Walker A motif; other site 985002003477 ATP binding site [chemical binding]; other site 985002003478 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 985002003479 Walker B motif; other site 985002003480 arginine finger; other site 985002003481 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 985002003482 transcriptional repressor CodY; Validated; Region: PRK04158 985002003483 CodY GAF-like domain; Region: CodY; pfam06018 985002003484 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 985002003485 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 985002003486 rRNA interaction site [nucleotide binding]; other site 985002003487 S8 interaction site; other site 985002003488 putative laminin-1 binding site; other site 985002003489 elongation factor Ts; Provisional; Region: tsf; PRK09377 985002003490 UBA/TS-N domain; Region: UBA; pfam00627 985002003491 Elongation factor TS; Region: EF_TS; pfam00889 985002003492 Elongation factor TS; Region: EF_TS; pfam00889 985002003493 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 985002003494 putative nucleotide binding site [chemical binding]; other site 985002003495 uridine monophosphate binding site [chemical binding]; other site 985002003496 homohexameric interface [polypeptide binding]; other site 985002003497 ribosome recycling factor; Reviewed; Region: frr; PRK00083 985002003498 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 985002003499 hinge region; other site 985002003500 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 985002003501 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 985002003502 catalytic residue [active] 985002003503 putative FPP diphosphate binding site; other site 985002003504 putative FPP binding hydrophobic cleft; other site 985002003505 dimer interface [polypeptide binding]; other site 985002003506 putative IPP diphosphate binding site; other site 985002003507 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 985002003508 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 985002003509 RIP metalloprotease RseP; Region: TIGR00054 985002003510 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 985002003511 active site 985002003512 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 985002003513 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 985002003514 protein binding site [polypeptide binding]; other site 985002003515 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 985002003516 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 985002003517 putative substrate binding region [chemical binding]; other site 985002003518 putative substrate binding region [chemical binding]; other site 985002003519 prolyl-tRNA synthetase; Provisional; Region: PRK09194 985002003520 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 985002003521 dimer interface [polypeptide binding]; other site 985002003522 motif 1; other site 985002003523 active site 985002003524 motif 2; other site 985002003525 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 985002003526 putative deacylase active site [active] 985002003527 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 985002003528 active site 985002003529 motif 3; other site 985002003530 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 985002003531 anticodon binding site; other site 985002003532 DNA polymerase III PolC; Validated; Region: polC; PRK00448 985002003533 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 985002003534 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 985002003535 generic binding surface II; other site 985002003536 generic binding surface I; other site 985002003537 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 985002003538 active site 985002003539 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 985002003540 active site 985002003541 catalytic site [active] 985002003542 substrate binding site [chemical binding]; other site 985002003543 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 985002003544 ribosome maturation protein RimP; Reviewed; Region: PRK00092 985002003545 Sm and related proteins; Region: Sm_like; cl00259 985002003546 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 985002003547 putative oligomer interface [polypeptide binding]; other site 985002003548 putative RNA binding site [nucleotide binding]; other site 985002003549 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 985002003550 NusA N-terminal domain; Region: NusA_N; pfam08529 985002003551 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 985002003552 RNA binding site [nucleotide binding]; other site 985002003553 homodimer interface [polypeptide binding]; other site 985002003554 NusA-like KH domain; Region: KH_5; pfam13184 985002003555 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 985002003556 G-X-X-G motif; other site 985002003557 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 985002003558 putative RNA binding cleft [nucleotide binding]; other site 985002003559 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 985002003560 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 985002003561 translation initiation factor IF-2; Region: IF-2; TIGR00487 985002003562 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 985002003563 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 985002003564 G1 box; other site 985002003565 putative GEF interaction site [polypeptide binding]; other site 985002003566 GTP/Mg2+ binding site [chemical binding]; other site 985002003567 Switch I region; other site 985002003568 G2 box; other site 985002003569 G3 box; other site 985002003570 Switch II region; other site 985002003571 G4 box; other site 985002003572 G5 box; other site 985002003573 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 985002003574 Translation-initiation factor 2; Region: IF-2; pfam11987 985002003575 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 985002003576 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 985002003577 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 985002003578 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 985002003579 RNA binding site [nucleotide binding]; other site 985002003580 active site 985002003581 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 985002003582 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 985002003583 active site 985002003584 Riboflavin kinase; Region: Flavokinase; smart00904 985002003585 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 985002003586 16S/18S rRNA binding site [nucleotide binding]; other site 985002003587 S13e-L30e interaction site [polypeptide binding]; other site 985002003588 25S rRNA binding site [nucleotide binding]; other site 985002003589 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 985002003590 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 985002003591 RNase E interface [polypeptide binding]; other site 985002003592 trimer interface [polypeptide binding]; other site 985002003593 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 985002003594 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 985002003595 RNase E interface [polypeptide binding]; other site 985002003596 trimer interface [polypeptide binding]; other site 985002003597 active site 985002003598 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 985002003599 putative nucleic acid binding region [nucleotide binding]; other site 985002003600 G-X-X-G motif; other site 985002003601 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 985002003602 RNA binding site [nucleotide binding]; other site 985002003603 domain interface; other site 985002003604 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 985002003605 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 985002003606 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 985002003607 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 985002003608 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 985002003609 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 985002003610 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 985002003611 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 985002003612 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 985002003613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 985002003614 DNA-binding site [nucleotide binding]; DNA binding site 985002003615 UTRA domain; Region: UTRA; pfam07702 985002003616 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 985002003617 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 985002003618 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 985002003619 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 985002003620 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 985002003621 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 985002003622 classical (c) SDRs; Region: SDR_c; cd05233 985002003623 NAD(P) binding site [chemical binding]; other site 985002003624 active site 985002003625 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 985002003626 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 985002003627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 985002003628 non-specific DNA binding site [nucleotide binding]; other site 985002003629 salt bridge; other site 985002003630 sequence-specific DNA binding site [nucleotide binding]; other site 985002003631 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 985002003632 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 985002003633 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 985002003634 putative MPT binding site; other site 985002003635 recombinase A; Provisional; Region: recA; PRK09354 985002003636 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 985002003637 hexamer interface [polypeptide binding]; other site 985002003638 Walker A motif; other site 985002003639 ATP binding site [chemical binding]; other site 985002003640 Walker B motif; other site 985002003641 phosphodiesterase; Provisional; Region: PRK12704 985002003642 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 985002003643 Zn2+ binding site [ion binding]; other site 985002003644 Mg2+ binding site [ion binding]; other site 985002003645 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 985002003646 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 985002003647 putative active site [active] 985002003648 metal binding site [ion binding]; metal-binding site 985002003649 homodimer binding site [polypeptide binding]; other site 985002003650 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 985002003651 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 985002003652 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 985002003653 dimer interface [polypeptide binding]; other site 985002003654 PYR/PP interface [polypeptide binding]; other site 985002003655 TPP binding site [chemical binding]; other site 985002003656 substrate binding site [chemical binding]; other site 985002003657 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 985002003658 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 985002003659 TPP-binding site [chemical binding]; other site 985002003660 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 985002003661 Uncharacterized conserved protein [Function unknown]; Region: COG0011 985002003662 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 985002003663 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 985002003664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 985002003665 FeS/SAM binding site; other site 985002003666 TRAM domain; Region: TRAM; pfam01938 985002003667 Predicted membrane protein [Function unknown]; Region: COG4550 985002003668 Predicted membrane protein [Function unknown]; Region: COG4732 985002003669 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 985002003670 MutS domain I; Region: MutS_I; pfam01624 985002003671 MutS domain II; Region: MutS_II; pfam05188 985002003672 MutS domain III; Region: MutS_III; pfam05192 985002003673 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 985002003674 Walker A/P-loop; other site 985002003675 ATP binding site [chemical binding]; other site 985002003676 Q-loop/lid; other site 985002003677 ABC transporter signature motif; other site 985002003678 Walker B; other site 985002003679 D-loop; other site 985002003680 H-loop/switch region; other site 985002003681 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 985002003682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002003683 ATP binding site [chemical binding]; other site 985002003684 Mg2+ binding site [ion binding]; other site 985002003685 G-X-G motif; other site 985002003686 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 985002003687 ATP binding site [chemical binding]; other site 985002003688 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 985002003689 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 985002003690 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 985002003691 amphipathic channel; other site 985002003692 Asn-Pro-Ala signature motifs; other site 985002003693 glycerol kinase; Provisional; Region: glpK; PRK00047 985002003694 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 985002003695 N- and C-terminal domain interface [polypeptide binding]; other site 985002003696 active site 985002003697 MgATP binding site [chemical binding]; other site 985002003698 catalytic site [active] 985002003699 metal binding site [ion binding]; metal-binding site 985002003700 glycerol binding site [chemical binding]; other site 985002003701 homotetramer interface [polypeptide binding]; other site 985002003702 homodimer interface [polypeptide binding]; other site 985002003703 FBP binding site [chemical binding]; other site 985002003704 protein IIAGlc interface [polypeptide binding]; other site 985002003705 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 985002003706 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 985002003707 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 985002003708 PGAP1-like protein; Region: PGAP1; pfam07819 985002003709 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 985002003710 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 985002003711 bacterial Hfq-like; Region: Hfq; cd01716 985002003712 hexamer interface [polypeptide binding]; other site 985002003713 Sm1 motif; other site 985002003714 RNA binding site [nucleotide binding]; other site 985002003715 Sm2 motif; other site 985002003716 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 985002003717 catalytic residues [active] 985002003718 dimer interface [polypeptide binding]; other site 985002003719 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 985002003720 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 985002003721 HflX GTPase family; Region: HflX; cd01878 985002003722 G1 box; other site 985002003723 GTP/Mg2+ binding site [chemical binding]; other site 985002003724 Switch I region; other site 985002003725 G2 box; other site 985002003726 G3 box; other site 985002003727 Switch II region; other site 985002003728 G4 box; other site 985002003729 G5 box; other site 985002003730 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 985002003731 Aluminium resistance protein; Region: Alum_res; pfam06838 985002003732 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 985002003733 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 985002003734 DNA binding residues [nucleotide binding] 985002003735 putative dimer interface [polypeptide binding]; other site 985002003736 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 985002003737 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 985002003738 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 985002003739 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 985002003740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 985002003741 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 985002003742 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 985002003743 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 985002003744 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 985002003745 catalytic residue [active] 985002003746 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 985002003747 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 985002003748 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 985002003749 putative active site [active] 985002003750 catalytic site [active] 985002003751 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 985002003752 putative active site [active] 985002003753 catalytic site [active] 985002003754 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 985002003755 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 985002003756 Walker A/P-loop; other site 985002003757 ATP binding site [chemical binding]; other site 985002003758 Q-loop/lid; other site 985002003759 ABC transporter signature motif; other site 985002003760 Walker B; other site 985002003761 D-loop; other site 985002003762 H-loop/switch region; other site 985002003763 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 985002003764 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 985002003765 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 985002003766 Histidine kinase; Region: HisKA_3; pfam07730 985002003767 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 985002003768 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 985002003769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002003770 active site 985002003771 phosphorylation site [posttranslational modification] 985002003772 intermolecular recognition site; other site 985002003773 dimerization interface [polypeptide binding]; other site 985002003774 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 985002003775 DNA binding residues [nucleotide binding] 985002003776 dimerization interface [polypeptide binding]; other site 985002003777 Staphylococcal nuclease homologues; Region: SNc; smart00318 985002003778 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 985002003779 Catalytic site; other site 985002003780 AAA domain; Region: AAA_11; pfam13086 985002003781 aspartate kinase; Reviewed; Region: PRK09034 985002003782 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 985002003783 putative catalytic residues [active] 985002003784 putative nucleotide binding site [chemical binding]; other site 985002003785 putative aspartate binding site [chemical binding]; other site 985002003786 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 985002003787 allosteric regulatory residue; other site 985002003788 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 985002003789 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 985002003790 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 985002003791 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 985002003792 threonine synthase; Reviewed; Region: PRK06721 985002003793 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 985002003794 homodimer interface [polypeptide binding]; other site 985002003795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002003796 catalytic residue [active] 985002003797 homoserine kinase; Provisional; Region: PRK01212 985002003798 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 985002003799 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 985002003800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002003801 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 985002003802 active site 985002003803 motif I; other site 985002003804 motif II; other site 985002003805 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 985002003806 lysine transporter; Provisional; Region: PRK10836 985002003807 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 985002003808 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 985002003809 tetramer interface [polypeptide binding]; other site 985002003810 heme binding pocket [chemical binding]; other site 985002003811 NADPH binding site [chemical binding]; other site 985002003812 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 985002003813 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 985002003814 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 985002003815 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 985002003816 active site 985002003817 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 985002003818 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 985002003819 LexA repressor; Validated; Region: PRK00215 985002003820 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 985002003821 putative DNA binding site [nucleotide binding]; other site 985002003822 putative Zn2+ binding site [ion binding]; other site 985002003823 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 985002003824 Catalytic site [active] 985002003825 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 985002003826 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 985002003827 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 985002003828 TPP-binding site [chemical binding]; other site 985002003829 dimer interface [polypeptide binding]; other site 985002003830 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 985002003831 PYR/PP interface [polypeptide binding]; other site 985002003832 dimer interface [polypeptide binding]; other site 985002003833 TPP binding site [chemical binding]; other site 985002003834 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 985002003835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 985002003836 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 985002003837 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 985002003838 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 985002003839 active site 985002003840 metal binding site [ion binding]; metal-binding site 985002003841 DNA binding site [nucleotide binding] 985002003842 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 985002003843 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 985002003844 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 985002003845 Walker A/P-loop; other site 985002003846 ATP binding site [chemical binding]; other site 985002003847 Q-loop/lid; other site 985002003848 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 985002003849 ABC transporter signature motif; other site 985002003850 Walker B; other site 985002003851 D-loop; other site 985002003852 H-loop/switch region; other site 985002003853 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 985002003854 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 985002003855 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 985002003856 aconitate hydratase; Validated; Region: PRK09277 985002003857 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 985002003858 substrate binding site [chemical binding]; other site 985002003859 ligand binding site [chemical binding]; other site 985002003860 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 985002003861 substrate binding site [chemical binding]; other site 985002003862 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 985002003863 active site 985002003864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 985002003865 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 985002003866 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 985002003867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002003868 ATP binding site [chemical binding]; other site 985002003869 Mg2+ binding site [ion binding]; other site 985002003870 G-X-G motif; other site 985002003871 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 985002003872 anchoring element; other site 985002003873 dimer interface [polypeptide binding]; other site 985002003874 ATP binding site [chemical binding]; other site 985002003875 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 985002003876 active site 985002003877 putative metal-binding site [ion binding]; other site 985002003878 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 985002003879 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 985002003880 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 985002003881 CAP-like domain; other site 985002003882 active site 985002003883 primary dimer interface [polypeptide binding]; other site 985002003884 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 985002003885 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 985002003886 amino acid carrier protein; Region: agcS; TIGR00835 985002003887 CAT RNA binding domain; Region: CAT_RBD; smart01061 985002003888 transcriptional antiterminator BglG; Provisional; Region: PRK09772 985002003889 PRD domain; Region: PRD; pfam00874 985002003890 PRD domain; Region: PRD; pfam00874 985002003891 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 985002003892 Domain of unknown function DUF20; Region: UPF0118; pfam01594 985002003893 Predicted integral membrane protein [Function unknown]; Region: COG0392 985002003894 Uncharacterized conserved protein [Function unknown]; Region: COG2898 985002003895 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 985002003896 methionine sulfoxide reductase A; Provisional; Region: PRK14054 985002003897 Transcriptional regulator [Transcription]; Region: LytR; COG1316 985002003898 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 985002003899 active site 1 [active] 985002003900 dimer interface [polypeptide binding]; other site 985002003901 hexamer interface [polypeptide binding]; other site 985002003902 active site 2 [active] 985002003903 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 985002003904 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 985002003905 active site 985002003906 DNA binding site [nucleotide binding] 985002003907 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 985002003908 prephenate dehydrogenase; Validated; Region: PRK06545 985002003909 prephenate dehydrogenase; Validated; Region: PRK08507 985002003910 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 985002003911 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 985002003912 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 985002003913 metal binding site [ion binding]; metal-binding site 985002003914 anthranilate synthase component I; Provisional; Region: PRK13567 985002003915 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 985002003916 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 985002003917 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 985002003918 Glutamine amidotransferase class-I; Region: GATase; pfam00117 985002003919 glutamine binding [chemical binding]; other site 985002003920 catalytic triad [active] 985002003921 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 985002003922 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 985002003923 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 985002003924 active site 985002003925 ribulose/triose binding site [chemical binding]; other site 985002003926 phosphate binding site [ion binding]; other site 985002003927 substrate (anthranilate) binding pocket [chemical binding]; other site 985002003928 product (indole) binding pocket [chemical binding]; other site 985002003929 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 985002003930 active site 985002003931 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 985002003932 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 985002003933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002003934 catalytic residue [active] 985002003935 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 985002003936 substrate binding site [chemical binding]; other site 985002003937 active site 985002003938 catalytic residues [active] 985002003939 heterodimer interface [polypeptide binding]; other site 985002003940 FemAB family; Region: FemAB; pfam02388 985002003941 FlxA-like protein; Region: FlxA; pfam14282 985002003942 FemAB family; Region: FemAB; pfam02388 985002003943 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 985002003944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002003945 active site 985002003946 motif I; other site 985002003947 motif II; other site 985002003948 SWIM zinc finger; Region: SWIM; pfam04434 985002003949 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 985002003950 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 985002003951 Walker A/P-loop; other site 985002003952 ATP binding site [chemical binding]; other site 985002003953 Q-loop/lid; other site 985002003954 ABC transporter signature motif; other site 985002003955 Walker B; other site 985002003956 D-loop; other site 985002003957 H-loop/switch region; other site 985002003958 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 985002003959 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 985002003960 Walker A/P-loop; other site 985002003961 ATP binding site [chemical binding]; other site 985002003962 Q-loop/lid; other site 985002003963 ABC transporter signature motif; other site 985002003964 Walker B; other site 985002003965 D-loop; other site 985002003966 H-loop/switch region; other site 985002003967 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 985002003968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002003969 dimer interface [polypeptide binding]; other site 985002003970 conserved gate region; other site 985002003971 putative PBP binding loops; other site 985002003972 ABC-ATPase subunit interface; other site 985002003973 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 985002003974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 985002003975 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 985002003976 oligoendopeptidase F; Region: pepF; TIGR00181 985002003977 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 985002003978 active site 985002003979 Zn binding site [ion binding]; other site 985002003980 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 985002003981 PhoU domain; Region: PhoU; pfam01895 985002003982 PhoU domain; Region: PhoU; pfam01895 985002003983 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 985002003984 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 985002003985 Walker A/P-loop; other site 985002003986 ATP binding site [chemical binding]; other site 985002003987 Q-loop/lid; other site 985002003988 ABC transporter signature motif; other site 985002003989 Walker B; other site 985002003990 D-loop; other site 985002003991 H-loop/switch region; other site 985002003992 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 985002003993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002003994 dimer interface [polypeptide binding]; other site 985002003995 conserved gate region; other site 985002003996 putative PBP binding loops; other site 985002003997 ABC-ATPase subunit interface; other site 985002003998 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 985002003999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002004000 dimer interface [polypeptide binding]; other site 985002004001 conserved gate region; other site 985002004002 ABC-ATPase subunit interface; other site 985002004003 phosphate binding protein; Region: ptsS_2; TIGR02136 985002004004 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 985002004005 S1 domain; Region: S1_2; pfam13509 985002004006 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 985002004007 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 985002004008 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 985002004009 ABC transporter; Region: ABC_tran_2; pfam12848 985002004010 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 985002004011 aspartate kinase; Reviewed; Region: PRK06635 985002004012 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 985002004013 putative nucleotide binding site [chemical binding]; other site 985002004014 putative catalytic residues [active] 985002004015 putative Mg ion binding site [ion binding]; other site 985002004016 putative aspartate binding site [chemical binding]; other site 985002004017 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 985002004018 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 985002004019 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 985002004020 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 985002004021 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 985002004022 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 985002004023 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 985002004024 dimer interface [polypeptide binding]; other site 985002004025 active site 985002004026 catalytic residue [active] 985002004027 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 985002004028 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 985002004029 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 985002004030 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 985002004031 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 985002004032 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 985002004033 active site 985002004034 trimer interface [polypeptide binding]; other site 985002004035 substrate binding site [chemical binding]; other site 985002004036 CoA binding site [chemical binding]; other site 985002004037 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 985002004038 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 985002004039 metal binding site [ion binding]; metal-binding site 985002004040 dimer interface [polypeptide binding]; other site 985002004041 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 985002004042 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 985002004043 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 985002004044 catalytic residue [active] 985002004045 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 985002004046 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 985002004047 active site 985002004048 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 985002004049 substrate binding site [chemical binding]; other site 985002004050 catalytic residues [active] 985002004051 dimer interface [polypeptide binding]; other site 985002004052 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 985002004053 DNA-binding site [nucleotide binding]; DNA binding site 985002004054 RNA-binding motif; other site 985002004055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 985002004056 acylphosphatase; Provisional; Region: PRK14431 985002004057 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 985002004058 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 985002004059 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 985002004060 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 985002004061 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 985002004062 metal ion-dependent adhesion site (MIDAS); other site 985002004063 MoxR-like ATPases [General function prediction only]; Region: COG0714 985002004064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002004065 Walker A motif; other site 985002004066 ATP binding site [chemical binding]; other site 985002004067 Walker B motif; other site 985002004068 arginine finger; other site 985002004069 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 985002004070 active site 985002004071 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 985002004072 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 985002004073 E3 interaction surface; other site 985002004074 lipoyl attachment site [posttranslational modification]; other site 985002004075 e3 binding domain; Region: E3_binding; pfam02817 985002004076 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 985002004077 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 985002004078 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 985002004079 TPP-binding site [chemical binding]; other site 985002004080 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 985002004081 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 985002004082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 985002004083 HAMP domain; Region: HAMP; pfam00672 985002004084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 985002004085 dimer interface [polypeptide binding]; other site 985002004086 phosphorylation site [posttranslational modification] 985002004087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002004088 ATP binding site [chemical binding]; other site 985002004089 Mg2+ binding site [ion binding]; other site 985002004090 G-X-G motif; other site 985002004091 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 985002004092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002004093 active site 985002004094 phosphorylation site [posttranslational modification] 985002004095 intermolecular recognition site; other site 985002004096 dimerization interface [polypeptide binding]; other site 985002004097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 985002004098 DNA binding site [nucleotide binding] 985002004099 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 985002004100 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 985002004101 active site 985002004102 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 985002004103 active site 985002004104 homodimer interface [polypeptide binding]; other site 985002004105 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 985002004106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002004107 Coenzyme A binding pocket [chemical binding]; other site 985002004108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 985002004109 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 985002004110 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 985002004111 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 985002004112 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 985002004113 C-terminal peptidase (prc); Region: prc; TIGR00225 985002004114 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 985002004115 protein binding site [polypeptide binding]; other site 985002004116 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 985002004117 Catalytic dyad [active] 985002004118 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 985002004119 hypothetical protein; Provisional; Region: PRK13672 985002004120 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 985002004121 HPr interaction site; other site 985002004122 glycerol kinase (GK) interaction site [polypeptide binding]; other site 985002004123 active site 985002004124 phosphorylation site [posttranslational modification] 985002004125 methionine sulfoxide reductase B; Provisional; Region: PRK00222 985002004126 SelR domain; Region: SelR; pfam01641 985002004127 methionine sulfoxide reductase A; Provisional; Region: PRK13014 985002004128 EDD domain protein, DegV family; Region: DegV; TIGR00762 985002004129 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 985002004130 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 985002004131 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 985002004132 folate binding site [chemical binding]; other site 985002004133 NADP+ binding site [chemical binding]; other site 985002004134 thymidylate synthase; Region: thym_sym; TIGR03284 985002004135 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 985002004136 dimerization interface [polypeptide binding]; other site 985002004137 active site 985002004138 Disulphide isomerase; Region: Disulph_isomer; cl05813 985002004139 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 985002004140 Virulence factor; Region: Virulence_fact; pfam13769 985002004141 HEAT repeats; Region: HEAT_2; pfam13646 985002004142 HEAT repeat; Region: HEAT; pfam02985 985002004143 HEAT repeats; Region: HEAT_2; pfam13646 985002004144 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 985002004145 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 985002004146 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 985002004147 RNA/DNA hybrid binding site [nucleotide binding]; other site 985002004148 active site 985002004149 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 985002004150 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 985002004151 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 985002004152 GA module; Region: GA; smart00844 985002004153 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 985002004154 GA module; Region: GA; smart00844 985002004155 GA module; Region: GA; smart00844 985002004156 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 985002004157 GA module; Region: GA; smart00844 985002004158 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 985002004159 GA module; Region: GA; smart00844 985002004160 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 985002004161 GA module; Region: GA; smart00844 985002004162 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 985002004163 GA module; Region: GA; smart00844 985002004164 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 985002004165 GA module; Region: GA; pfam01468 985002004166 GA module; Region: GA; smart00844 985002004167 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 985002004168 GA module; Region: GA; smart00844 985002004169 GA module; Region: GA; smart00844 985002004170 Major Facilitator Superfamily; Region: MFS_1; pfam07690 985002004171 Amino acid permease; Region: AA_permease_2; pfam13520 985002004172 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 985002004173 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 985002004174 tetramer interface [polypeptide binding]; other site 985002004175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002004176 catalytic residue [active] 985002004177 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 985002004178 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 985002004179 hexamer interface [polypeptide binding]; other site 985002004180 ligand binding site [chemical binding]; other site 985002004181 putative active site [active] 985002004182 NAD(P) binding site [chemical binding]; other site 985002004183 5'-3' exonuclease; Region: 53EXOc; smart00475 985002004184 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 985002004185 active site 985002004186 metal binding site 1 [ion binding]; metal-binding site 985002004187 putative 5' ssDNA interaction site; other site 985002004188 metal binding site 3; metal-binding site 985002004189 metal binding site 2 [ion binding]; metal-binding site 985002004190 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 985002004191 putative DNA binding site [nucleotide binding]; other site 985002004192 putative metal binding site [ion binding]; other site 985002004193 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 985002004194 Dynamin family; Region: Dynamin_N; pfam00350 985002004195 G1 box; other site 985002004196 GTP/Mg2+ binding site [chemical binding]; other site 985002004197 G2 box; other site 985002004198 Switch I region; other site 985002004199 G3 box; other site 985002004200 Switch II region; other site 985002004201 G4 box; other site 985002004202 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 985002004203 Dynamin family; Region: Dynamin_N; pfam00350 985002004204 G1 box; other site 985002004205 GTP/Mg2+ binding site [chemical binding]; other site 985002004206 G2 box; other site 985002004207 Switch I region; other site 985002004208 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 985002004209 G3 box; other site 985002004210 Switch II region; other site 985002004211 GTP/Mg2+ binding site [chemical binding]; other site 985002004212 G4 box; other site 985002004213 G5 box; other site 985002004214 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 985002004215 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 985002004216 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 985002004217 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 985002004218 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 985002004219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 985002004220 cell division protein GpsB; Provisional; Region: PRK14127 985002004221 DivIVA domain; Region: DivI1A_domain; TIGR03544 985002004222 hypothetical protein; Provisional; Region: PRK13660 985002004223 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 985002004224 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 985002004225 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 985002004226 Transglycosylase; Region: Transgly; pfam00912 985002004227 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 985002004228 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 985002004229 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 985002004230 minor groove reading motif; other site 985002004231 helix-hairpin-helix signature motif; other site 985002004232 substrate binding pocket [chemical binding]; other site 985002004233 active site 985002004234 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 985002004235 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 985002004236 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 985002004237 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 985002004238 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 985002004239 putative dimer interface [polypeptide binding]; other site 985002004240 putative anticodon binding site; other site 985002004241 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 985002004242 homodimer interface [polypeptide binding]; other site 985002004243 motif 1; other site 985002004244 motif 2; other site 985002004245 active site 985002004246 motif 3; other site 985002004247 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 985002004248 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 985002004249 active site 985002004250 catalytic site [active] 985002004251 substrate binding site [chemical binding]; other site 985002004252 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 985002004253 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 985002004254 Biotin operon repressor [Transcription]; Region: BirA; COG1654 985002004255 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 985002004256 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 985002004257 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 985002004258 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 985002004259 active site 985002004260 NTP binding site [chemical binding]; other site 985002004261 metal binding triad [ion binding]; metal-binding site 985002004262 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 985002004263 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 985002004264 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 985002004265 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 985002004266 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 985002004267 homodimer interface [polypeptide binding]; other site 985002004268 metal binding site [ion binding]; metal-binding site 985002004269 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 985002004270 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 985002004271 Uncharacterized conserved protein [Function unknown]; Region: COG5582 985002004272 UPF0302 domain; Region: UPF0302; pfam08864 985002004273 IDEAL domain; Region: IDEAL; pfam08858 985002004274 TPR repeat; Region: TPR_11; pfam13414 985002004275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 985002004276 binding surface 985002004277 TPR motif; other site 985002004278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 985002004279 TPR motif; other site 985002004280 binding surface 985002004281 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 985002004282 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 985002004283 hinge; other site 985002004284 active site 985002004285 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 985002004286 active site 985002004287 NAD binding site [chemical binding]; other site 985002004288 metal binding site [ion binding]; metal-binding site 985002004289 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 985002004290 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 985002004291 Tetramer interface [polypeptide binding]; other site 985002004292 active site 985002004293 FMN-binding site [chemical binding]; other site 985002004294 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 985002004295 active site 985002004296 multimer interface [polypeptide binding]; other site 985002004297 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 985002004298 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 985002004299 substrate binding pocket [chemical binding]; other site 985002004300 chain length determination region; other site 985002004301 substrate-Mg2+ binding site; other site 985002004302 catalytic residues [active] 985002004303 aspartate-rich region 1; other site 985002004304 active site lid residues [active] 985002004305 aspartate-rich region 2; other site 985002004306 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 985002004307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002004308 S-adenosylmethionine binding site [chemical binding]; other site 985002004309 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 985002004310 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 985002004311 IHF dimer interface [polypeptide binding]; other site 985002004312 IHF - DNA interface [nucleotide binding]; other site 985002004313 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 985002004314 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 985002004315 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 985002004316 GTP-binding protein Der; Reviewed; Region: PRK00093 985002004317 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 985002004318 G1 box; other site 985002004319 GTP/Mg2+ binding site [chemical binding]; other site 985002004320 Switch I region; other site 985002004321 G2 box; other site 985002004322 Switch II region; other site 985002004323 G3 box; other site 985002004324 G4 box; other site 985002004325 G5 box; other site 985002004326 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 985002004327 G1 box; other site 985002004328 GTP/Mg2+ binding site [chemical binding]; other site 985002004329 Switch I region; other site 985002004330 G2 box; other site 985002004331 G3 box; other site 985002004332 Switch II region; other site 985002004333 G4 box; other site 985002004334 G5 box; other site 985002004335 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 985002004336 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 985002004337 RNA binding site [nucleotide binding]; other site 985002004338 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 985002004339 RNA binding site [nucleotide binding]; other site 985002004340 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 985002004341 RNA binding site [nucleotide binding]; other site 985002004342 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 985002004343 RNA binding site [nucleotide binding]; other site 985002004344 cytidylate kinase; Provisional; Region: cmk; PRK00023 985002004345 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 985002004346 CMP-binding site; other site 985002004347 The sites determining sugar specificity; other site 985002004348 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 985002004349 active site 985002004350 homotetramer interface [polypeptide binding]; other site 985002004351 homodimer interface [polypeptide binding]; other site 985002004352 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 985002004353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 985002004354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 985002004355 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 985002004356 ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614 985002004357 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 985002004358 ATP binding site [chemical binding]; other site 985002004359 putative Mg++ binding site [ion binding]; other site 985002004360 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 985002004361 nucleotide binding region [chemical binding]; other site 985002004362 ATP-binding site [chemical binding]; other site 985002004363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 985002004364 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 985002004365 Predicted membrane protein [Function unknown]; Region: COG3601 985002004366 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 985002004367 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 985002004368 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 985002004369 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 985002004370 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 985002004371 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 985002004372 dimerization interface [polypeptide binding]; other site 985002004373 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 985002004374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 985002004375 dimer interface [polypeptide binding]; other site 985002004376 phosphorylation site [posttranslational modification] 985002004377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002004378 ATP binding site [chemical binding]; other site 985002004379 Mg2+ binding site [ion binding]; other site 985002004380 G-X-G motif; other site 985002004381 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 985002004382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002004383 active site 985002004384 phosphorylation site [posttranslational modification] 985002004385 intermolecular recognition site; other site 985002004386 dimerization interface [polypeptide binding]; other site 985002004387 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 985002004388 DNA binding site [nucleotide binding] 985002004389 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 985002004390 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 985002004391 RNA binding surface [nucleotide binding]; other site 985002004392 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 985002004393 active site 985002004394 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 985002004395 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 985002004396 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 985002004397 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 985002004398 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 985002004399 active site 985002004400 Int/Topo IB signature motif; other site 985002004401 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 985002004402 metal binding site 2 [ion binding]; metal-binding site 985002004403 putative DNA binding helix; other site 985002004404 metal binding site 1 [ion binding]; metal-binding site 985002004405 dimer interface [polypeptide binding]; other site 985002004406 structural Zn2+ binding site [ion binding]; other site 985002004407 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 985002004408 dimer interface [polypeptide binding]; other site 985002004409 ADP-ribose binding site [chemical binding]; other site 985002004410 active site 985002004411 nudix motif; other site 985002004412 metal binding site [ion binding]; metal-binding site 985002004413 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 985002004414 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 985002004415 active site 985002004416 catalytic tetrad [active] 985002004417 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 985002004418 classical (c) SDRs; Region: SDR_c; cd05233 985002004419 NAD(P) binding site [chemical binding]; other site 985002004420 active site 985002004421 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 985002004422 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 985002004423 ribonuclease Z; Region: RNase_Z; TIGR02651 985002004424 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 985002004425 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 985002004426 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 985002004427 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 985002004428 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 985002004429 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 985002004430 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 985002004431 Ca binding site [ion binding]; other site 985002004432 active site 985002004433 catalytic site [active] 985002004434 Transcriptional regulators [Transcription]; Region: PurR; COG1609 985002004435 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 985002004436 DNA binding site [nucleotide binding] 985002004437 domain linker motif; other site 985002004438 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 985002004439 putative ligand binding site [chemical binding]; other site 985002004440 putative dimerization interface [polypeptide binding]; other site 985002004441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 985002004442 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 985002004443 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 985002004444 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 985002004445 H+ Antiporter protein; Region: 2A0121; TIGR00900 985002004446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002004447 putative substrate translocation pore; other site 985002004448 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 985002004449 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 985002004450 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 985002004451 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 985002004452 peptidase T-like protein; Region: PepT-like; TIGR01883 985002004453 metal binding site [ion binding]; metal-binding site 985002004454 putative dimer interface [polypeptide binding]; other site 985002004455 Predicted membrane protein [Function unknown]; Region: COG4129 985002004456 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 985002004457 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 985002004458 Disulphide isomerase; Region: Disulph_isomer; pfam06491 985002004459 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 985002004460 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 985002004461 E3 interaction surface; other site 985002004462 lipoyl attachment site [posttranslational modification]; other site 985002004463 e3 binding domain; Region: E3_binding; pfam02817 985002004464 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 985002004465 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 985002004466 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 985002004467 alpha subunit interface [polypeptide binding]; other site 985002004468 TPP binding site [chemical binding]; other site 985002004469 heterodimer interface [polypeptide binding]; other site 985002004470 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 985002004471 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 985002004472 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 985002004473 tetramer interface [polypeptide binding]; other site 985002004474 TPP-binding site [chemical binding]; other site 985002004475 heterodimer interface [polypeptide binding]; other site 985002004476 phosphorylation loop region [posttranslational modification] 985002004477 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 985002004478 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 985002004479 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 985002004480 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 985002004481 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 985002004482 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 985002004483 Walker A/P-loop; other site 985002004484 ATP binding site [chemical binding]; other site 985002004485 Q-loop/lid; other site 985002004486 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 985002004487 ABC transporter signature motif; other site 985002004488 Walker B; other site 985002004489 D-loop; other site 985002004490 H-loop/switch region; other site 985002004491 arginine repressor; Provisional; Region: PRK04280 985002004492 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 985002004493 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 985002004494 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 985002004495 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 985002004496 substrate binding pocket [chemical binding]; other site 985002004497 chain length determination region; other site 985002004498 substrate-Mg2+ binding site; other site 985002004499 catalytic residues [active] 985002004500 aspartate-rich region 1; other site 985002004501 active site lid residues [active] 985002004502 aspartate-rich region 2; other site 985002004503 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 985002004504 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 985002004505 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 985002004506 generic binding surface II; other site 985002004507 generic binding surface I; other site 985002004508 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 985002004509 putative RNA binding site [nucleotide binding]; other site 985002004510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 985002004511 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 985002004512 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 985002004513 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 985002004514 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 985002004515 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 985002004516 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 985002004517 carboxyltransferase (CT) interaction site; other site 985002004518 biotinylation site [posttranslational modification]; other site 985002004519 elongation factor P; Validated; Region: PRK00529 985002004520 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 985002004521 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 985002004522 RNA binding site [nucleotide binding]; other site 985002004523 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 985002004524 RNA binding site [nucleotide binding]; other site 985002004525 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 985002004526 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 985002004527 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 985002004528 active site 985002004529 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 985002004530 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 985002004531 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 985002004532 active site residue [active] 985002004533 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 985002004534 tetramer interface [polypeptide binding]; other site 985002004535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002004536 catalytic residue [active] 985002004537 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 985002004538 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 985002004539 tetramer interface [polypeptide binding]; other site 985002004540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002004541 catalytic residue [active] 985002004542 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 985002004543 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 985002004544 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 985002004545 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 985002004546 ADP binding site [chemical binding]; other site 985002004547 magnesium binding site [ion binding]; other site 985002004548 putative shikimate binding site; other site 985002004549 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 985002004550 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 985002004551 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 985002004552 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 985002004553 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 985002004554 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 985002004555 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 985002004556 Type II/IV secretion system protein; Region: T2SE; pfam00437 985002004557 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 985002004558 Walker A motif; other site 985002004559 ATP binding site [chemical binding]; other site 985002004560 Walker B motif; other site 985002004561 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 985002004562 Uncharacterized conserved protein [Function unknown]; Region: COG0011 985002004563 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 985002004564 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 985002004565 Rhomboid family; Region: Rhomboid; pfam01694 985002004566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 985002004567 binding surface 985002004568 TPR motif; other site 985002004569 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 985002004570 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 985002004571 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 985002004572 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 985002004573 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 985002004574 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 985002004575 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 985002004576 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 985002004577 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 985002004578 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 985002004579 metal binding site 2 [ion binding]; metal-binding site 985002004580 putative DNA binding helix; other site 985002004581 metal binding site 1 [ion binding]; metal-binding site 985002004582 dimer interface [polypeptide binding]; other site 985002004583 structural Zn2+ binding site [ion binding]; other site 985002004584 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 985002004585 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 985002004586 ABC-ATPase subunit interface; other site 985002004587 dimer interface [polypeptide binding]; other site 985002004588 putative PBP binding regions; other site 985002004589 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 985002004590 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 985002004591 endonuclease IV; Provisional; Region: PRK01060 985002004592 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 985002004593 AP (apurinic/apyrimidinic) site pocket; other site 985002004594 DNA interaction; other site 985002004595 Metal-binding active site; metal-binding site 985002004596 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 985002004597 DEAD-like helicases superfamily; Region: DEXDc; smart00487 985002004598 ATP binding site [chemical binding]; other site 985002004599 Mg++ binding site [ion binding]; other site 985002004600 motif III; other site 985002004601 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 985002004602 nucleotide binding region [chemical binding]; other site 985002004603 ATP-binding site [chemical binding]; other site 985002004604 Uncharacterized conserved protein [Function unknown]; Region: COG0327 985002004605 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 985002004606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 985002004607 Uncharacterized conserved protein [Function unknown]; Region: COG0327 985002004608 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 985002004609 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 985002004610 Family of unknown function (DUF633); Region: DUF633; pfam04816 985002004611 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 985002004612 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 985002004613 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 985002004614 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 985002004615 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 985002004616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 985002004617 DNA binding residues [nucleotide binding] 985002004618 DNA primase, catalytic core; Region: dnaG; TIGR01391 985002004619 CHC2 zinc finger; Region: zf-CHC2; pfam01807 985002004620 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 985002004621 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 985002004622 active site 985002004623 metal binding site [ion binding]; metal-binding site 985002004624 interdomain interaction site; other site 985002004625 PEP synthetase regulatory protein; Provisional; Region: PRK05339 985002004626 FOG: CBS domain [General function prediction only]; Region: COG0517 985002004627 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 985002004628 glycyl-tRNA synthetase; Provisional; Region: PRK04173 985002004629 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 985002004630 motif 1; other site 985002004631 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 985002004632 active site 985002004633 motif 2; other site 985002004634 motif 3; other site 985002004635 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 985002004636 anticodon binding site; other site 985002004637 DNA repair protein RecO; Region: reco; TIGR00613 985002004638 Recombination protein O N terminal; Region: RecO_N; pfam11967 985002004639 Recombination protein O C terminal; Region: RecO_C; pfam02565 985002004640 GTPase Era; Reviewed; Region: era; PRK00089 985002004641 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 985002004642 G1 box; other site 985002004643 GTP/Mg2+ binding site [chemical binding]; other site 985002004644 Switch I region; other site 985002004645 G2 box; other site 985002004646 Switch II region; other site 985002004647 G3 box; other site 985002004648 G4 box; other site 985002004649 G5 box; other site 985002004650 KH domain; Region: KH_2; pfam07650 985002004651 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 985002004652 active site 985002004653 catalytic motif [active] 985002004654 Zn binding site [ion binding]; other site 985002004655 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 985002004656 metal-binding heat shock protein; Provisional; Region: PRK00016 985002004657 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 985002004658 PhoH-like protein; Region: PhoH; pfam02562 985002004659 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 985002004660 hypothetical protein; Provisional; Region: PRK13665 985002004661 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 985002004662 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 985002004663 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 985002004664 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 985002004665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 985002004666 FeS/SAM binding site; other site 985002004667 TRAM domain; Region: TRAM; cl01282 985002004668 RNA methyltransferase, RsmE family; Region: TIGR00046 985002004669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 985002004670 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 985002004671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002004672 S-adenosylmethionine binding site [chemical binding]; other site 985002004673 chaperone protein DnaJ; Provisional; Region: PRK14280 985002004674 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 985002004675 HSP70 interaction site [polypeptide binding]; other site 985002004676 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 985002004677 substrate binding site [polypeptide binding]; other site 985002004678 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 985002004679 Zn binding sites [ion binding]; other site 985002004680 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 985002004681 dimer interface [polypeptide binding]; other site 985002004682 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 985002004683 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 985002004684 nucleotide binding site [chemical binding]; other site 985002004685 NEF interaction site [polypeptide binding]; other site 985002004686 SBD interface [polypeptide binding]; other site 985002004687 heat shock protein GrpE; Provisional; Region: PRK14140 985002004688 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 985002004689 dimer interface [polypeptide binding]; other site 985002004690 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 985002004691 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 985002004692 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 985002004693 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 985002004694 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 985002004695 FeS/SAM binding site; other site 985002004696 HemN C-terminal domain; Region: HemN_C; pfam06969 985002004697 GTP-binding protein LepA; Provisional; Region: PRK05433 985002004698 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 985002004699 G1 box; other site 985002004700 putative GEF interaction site [polypeptide binding]; other site 985002004701 GTP/Mg2+ binding site [chemical binding]; other site 985002004702 Switch I region; other site 985002004703 G2 box; other site 985002004704 G3 box; other site 985002004705 Switch II region; other site 985002004706 G4 box; other site 985002004707 G5 box; other site 985002004708 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 985002004709 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 985002004710 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 985002004711 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 985002004712 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 985002004713 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 985002004714 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 985002004715 Competence protein; Region: Competence; pfam03772 985002004716 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 985002004717 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 985002004718 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 985002004719 catalytic motif [active] 985002004720 Zn binding site [ion binding]; other site 985002004721 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 985002004722 Helix-hairpin-helix motif; Region: HHH; pfam00633 985002004723 Methyltransferase domain; Region: Methyltransf_23; pfam13489 985002004724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002004725 S-adenosylmethionine binding site [chemical binding]; other site 985002004726 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 985002004727 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 985002004728 Zn2+ binding site [ion binding]; other site 985002004729 Mg2+ binding site [ion binding]; other site 985002004730 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 985002004731 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 985002004732 active site 985002004733 (T/H)XGH motif; other site 985002004734 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 985002004735 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 985002004736 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 985002004737 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 985002004738 shikimate binding site; other site 985002004739 NAD(P) binding site [chemical binding]; other site 985002004740 GTPase YqeH; Provisional; Region: PRK13796 985002004741 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 985002004742 GTP/Mg2+ binding site [chemical binding]; other site 985002004743 G4 box; other site 985002004744 G5 box; other site 985002004745 G1 box; other site 985002004746 Switch I region; other site 985002004747 G2 box; other site 985002004748 G3 box; other site 985002004749 Switch II region; other site 985002004750 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 985002004751 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002004752 active site 985002004753 motif I; other site 985002004754 motif II; other site 985002004755 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 985002004756 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 985002004757 Fic family protein [Function unknown]; Region: COG3177 985002004758 Fic/DOC family; Region: Fic; pfam02661 985002004759 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 985002004760 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 985002004761 putative active site [active] 985002004762 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 985002004763 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 985002004764 ATP-grasp domain; Region: ATP-grasp_4; cl17255 985002004765 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 985002004766 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 985002004767 carboxyltransferase (CT) interaction site; other site 985002004768 biotinylation site [posttranslational modification]; other site 985002004769 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 985002004770 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 985002004771 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 985002004772 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 985002004773 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 985002004774 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 985002004775 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 985002004776 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 985002004777 Sugar specificity; other site 985002004778 Pyrimidine base specificity; other site 985002004779 ATP-binding site [chemical binding]; other site 985002004780 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 985002004781 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 985002004782 Peptidase family U32; Region: Peptidase_U32; pfam01136 985002004783 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 985002004784 Peptidase family U32; Region: Peptidase_U32; pfam01136 985002004785 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 985002004786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002004787 S-adenosylmethionine binding site [chemical binding]; other site 985002004788 hypothetical protein; Provisional; Region: PRK13678 985002004789 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 985002004790 hypothetical protein; Provisional; Region: PRK05473 985002004791 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 985002004792 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 985002004793 motif 1; other site 985002004794 active site 985002004795 motif 2; other site 985002004796 motif 3; other site 985002004797 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 985002004798 DHHA1 domain; Region: DHHA1; pfam02272 985002004799 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 985002004800 AAA domain; Region: AAA_30; pfam13604 985002004801 Family description; Region: UvrD_C_2; pfam13538 985002004802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 985002004803 binding surface 985002004804 TPR repeat; Region: TPR_11; pfam13414 985002004805 TPR motif; other site 985002004806 Tetratricopeptide repeat; Region: TPR_16; pfam13432 985002004807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 985002004808 binding surface 985002004809 TPR motif; other site 985002004810 TPR repeat; Region: TPR_11; pfam13414 985002004811 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 985002004812 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 985002004813 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 985002004814 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 985002004815 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 985002004816 catalytic residue [active] 985002004817 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 985002004818 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 985002004819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 985002004820 Predicted transcriptional regulator [Transcription]; Region: COG1959 985002004821 Transcriptional regulator; Region: Rrf2; pfam02082 985002004822 recombination factor protein RarA; Reviewed; Region: PRK13342 985002004823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002004824 Walker A motif; other site 985002004825 ATP binding site [chemical binding]; other site 985002004826 Walker B motif; other site 985002004827 arginine finger; other site 985002004828 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 985002004829 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 985002004830 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 985002004831 putative ATP binding site [chemical binding]; other site 985002004832 putative substrate interface [chemical binding]; other site 985002004833 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 985002004834 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 985002004835 dimer interface [polypeptide binding]; other site 985002004836 anticodon binding site; other site 985002004837 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 985002004838 homodimer interface [polypeptide binding]; other site 985002004839 motif 1; other site 985002004840 active site 985002004841 motif 2; other site 985002004842 GAD domain; Region: GAD; pfam02938 985002004843 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 985002004844 motif 3; other site 985002004845 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 985002004846 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 985002004847 dimer interface [polypeptide binding]; other site 985002004848 motif 1; other site 985002004849 active site 985002004850 motif 2; other site 985002004851 motif 3; other site 985002004852 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 985002004853 anticodon binding site; other site 985002004854 Bacterial SH3 domain homologues; Region: SH3b; smart00287 985002004855 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 985002004856 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 985002004857 active site 985002004858 metal binding site [ion binding]; metal-binding site 985002004859 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 985002004860 putative active site [active] 985002004861 dimerization interface [polypeptide binding]; other site 985002004862 putative tRNAtyr binding site [nucleotide binding]; other site 985002004863 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 985002004864 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 985002004865 Zn2+ binding site [ion binding]; other site 985002004866 Mg2+ binding site [ion binding]; other site 985002004867 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 985002004868 synthetase active site [active] 985002004869 NTP binding site [chemical binding]; other site 985002004870 metal binding site [ion binding]; metal-binding site 985002004871 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 985002004872 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 985002004873 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 985002004874 active site 985002004875 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 985002004876 DHH family; Region: DHH; pfam01368 985002004877 DHHA1 domain; Region: DHHA1; pfam02272 985002004878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 985002004879 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 985002004880 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 985002004881 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 985002004882 Protein export membrane protein; Region: SecD_SecF; pfam02355 985002004883 Preprotein translocase subunit; Region: YajC; pfam02699 985002004884 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 985002004885 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 985002004886 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 985002004887 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 985002004888 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 985002004889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002004890 Walker A motif; other site 985002004891 ATP binding site [chemical binding]; other site 985002004892 Walker B motif; other site 985002004893 arginine finger; other site 985002004894 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 985002004895 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 985002004896 RuvA N terminal domain; Region: RuvA_N; pfam01330 985002004897 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 985002004898 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 985002004899 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 985002004900 GTPase CgtA; Reviewed; Region: obgE; PRK12297 985002004901 GTP1/OBG; Region: GTP1_OBG; pfam01018 985002004902 Obg GTPase; Region: Obg; cd01898 985002004903 G1 box; other site 985002004904 GTP/Mg2+ binding site [chemical binding]; other site 985002004905 Switch I region; other site 985002004906 G2 box; other site 985002004907 G3 box; other site 985002004908 Switch II region; other site 985002004909 G4 box; other site 985002004910 G5 box; other site 985002004911 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 985002004912 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 985002004913 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 985002004914 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 985002004915 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 985002004916 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 985002004917 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 985002004918 rod shape-determining protein MreC; Region: MreC; pfam04085 985002004919 hypothetical protein; Reviewed; Region: PRK00024 985002004920 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 985002004921 MPN+ (JAMM) motif; other site 985002004922 Zinc-binding site [ion binding]; other site 985002004923 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 985002004924 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 985002004925 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 985002004926 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 985002004927 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 985002004928 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 985002004929 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 985002004930 active site 985002004931 HIGH motif; other site 985002004932 nucleotide binding site [chemical binding]; other site 985002004933 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 985002004934 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 985002004935 active site 985002004936 KMSKS motif; other site 985002004937 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 985002004938 tRNA binding surface [nucleotide binding]; other site 985002004939 anticodon binding site; other site 985002004940 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 985002004941 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 985002004942 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 985002004943 Putative ammonia monooxygenase; Region: AmoA; pfam05145 985002004944 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 985002004945 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 985002004946 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 985002004947 inhibitor-cofactor binding pocket; inhibition site 985002004948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002004949 catalytic residue [active] 985002004950 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 985002004951 dimer interface [polypeptide binding]; other site 985002004952 active site 985002004953 Schiff base residues; other site 985002004954 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 985002004955 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 985002004956 active site 985002004957 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 985002004958 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 985002004959 domain interfaces; other site 985002004960 active site 985002004961 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 985002004962 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 985002004963 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 985002004964 tRNA; other site 985002004965 putative tRNA binding site [nucleotide binding]; other site 985002004966 putative NADP binding site [chemical binding]; other site 985002004967 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 985002004968 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 985002004969 G1 box; other site 985002004970 GTP/Mg2+ binding site [chemical binding]; other site 985002004971 Switch I region; other site 985002004972 G2 box; other site 985002004973 G3 box; other site 985002004974 Switch II region; other site 985002004975 G4 box; other site 985002004976 G5 box; other site 985002004977 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 985002004978 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 985002004979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002004980 Walker A motif; other site 985002004981 ATP binding site [chemical binding]; other site 985002004982 Walker B motif; other site 985002004983 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 985002004984 trigger factor; Provisional; Region: tig; PRK01490 985002004985 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 985002004986 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 985002004987 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 985002004988 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 985002004989 23S rRNA binding site [nucleotide binding]; other site 985002004990 L21 binding site [polypeptide binding]; other site 985002004991 L13 binding site [polypeptide binding]; other site 985002004992 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 985002004993 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 985002004994 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 985002004995 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 985002004996 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 985002004997 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 985002004998 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 985002004999 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 985002005000 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 985002005001 active site 985002005002 dimer interface [polypeptide binding]; other site 985002005003 motif 1; other site 985002005004 motif 2; other site 985002005005 motif 3; other site 985002005006 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 985002005007 anticodon binding site; other site 985002005008 primosomal protein DnaI; Reviewed; Region: PRK08939 985002005009 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 985002005010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002005011 Walker A motif; other site 985002005012 ATP binding site [chemical binding]; other site 985002005013 Walker B motif; other site 985002005014 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 985002005015 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 985002005016 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 985002005017 ATP cone domain; Region: ATP-cone; pfam03477 985002005018 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 985002005019 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 985002005020 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 985002005021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 985002005022 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 985002005023 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 985002005024 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 985002005025 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 985002005026 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 985002005027 CoA-binding site [chemical binding]; other site 985002005028 ATP-binding [chemical binding]; other site 985002005029 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 985002005030 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 985002005031 DNA binding site [nucleotide binding] 985002005032 catalytic residue [active] 985002005033 H2TH interface [polypeptide binding]; other site 985002005034 putative catalytic residues [active] 985002005035 turnover-facilitating residue; other site 985002005036 intercalation triad [nucleotide binding]; other site 985002005037 8OG recognition residue [nucleotide binding]; other site 985002005038 putative reading head residues; other site 985002005039 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 985002005040 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 985002005041 DNA polymerase I; Provisional; Region: PRK05755 985002005042 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 985002005043 active site 985002005044 metal binding site 1 [ion binding]; metal-binding site 985002005045 putative 5' ssDNA interaction site; other site 985002005046 metal binding site 3; metal-binding site 985002005047 metal binding site 2 [ion binding]; metal-binding site 985002005048 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 985002005049 putative DNA binding site [nucleotide binding]; other site 985002005050 putative metal binding site [ion binding]; other site 985002005051 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 985002005052 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 985002005053 active site 985002005054 DNA binding site [nucleotide binding] 985002005055 catalytic site [active] 985002005056 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 985002005057 Replication initiation factor; Region: Rep_trans; pfam02486 985002005058 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 985002005059 TcpE family; Region: TcpE; pfam12648 985002005060 AAA-like domain; Region: AAA_10; pfam12846 985002005061 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 985002005062 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 985002005063 ribonuclease E; Reviewed; Region: rne; PRK10811 985002005064 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 985002005065 Surface antigen [General function prediction only]; Region: COG3942 985002005066 CHAP domain; Region: CHAP; pfam05257 985002005067 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 985002005068 Homeodomain-like domain; Region: HTH_32; pfam13565 985002005069 Integrase core domain; Region: rve; pfam00665 985002005070 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 985002005071 PAS domain; Region: PAS; smart00091 985002005072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 985002005073 dimer interface [polypeptide binding]; other site 985002005074 phosphorylation site [posttranslational modification] 985002005075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002005076 ATP binding site [chemical binding]; other site 985002005077 Mg2+ binding site [ion binding]; other site 985002005078 G-X-G motif; other site 985002005079 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 985002005080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002005081 active site 985002005082 phosphorylation site [posttranslational modification] 985002005083 intermolecular recognition site; other site 985002005084 dimerization interface [polypeptide binding]; other site 985002005085 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 985002005086 DNA binding site [nucleotide binding] 985002005087 isocitrate dehydrogenase; Reviewed; Region: PRK07006 985002005088 isocitrate dehydrogenase; Validated; Region: PRK07362 985002005089 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 985002005090 dimer interface [polypeptide binding]; other site 985002005091 Citrate synthase; Region: Citrate_synt; pfam00285 985002005092 active site 985002005093 citrylCoA binding site [chemical binding]; other site 985002005094 oxalacetate/citrate binding site [chemical binding]; other site 985002005095 coenzyme A binding site [chemical binding]; other site 985002005096 catalytic triad [active] 985002005097 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 985002005098 pyruvate kinase; Provisional; Region: PRK06354 985002005099 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 985002005100 domain interfaces; other site 985002005101 active site 985002005102 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 985002005103 6-phosphofructokinase; Provisional; Region: PRK03202 985002005104 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 985002005105 active site 985002005106 ADP/pyrophosphate binding site [chemical binding]; other site 985002005107 dimerization interface [polypeptide binding]; other site 985002005108 allosteric effector site; other site 985002005109 fructose-1,6-bisphosphate binding site; other site 985002005110 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 985002005111 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 985002005112 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 985002005113 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 985002005114 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 985002005115 Malic enzyme, N-terminal domain; Region: malic; pfam00390 985002005116 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 985002005117 putative NAD(P) binding site [chemical binding]; other site 985002005118 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 985002005119 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 985002005120 active site 985002005121 PHP Thumb interface [polypeptide binding]; other site 985002005122 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 985002005123 generic binding surface I; other site 985002005124 generic binding surface II; other site 985002005125 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 985002005126 DHH family; Region: DHH; pfam01368 985002005127 DHHA1 domain; Region: DHHA1; pfam02272 985002005128 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 985002005129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 985002005130 DNA-binding site [nucleotide binding]; DNA binding site 985002005131 DRTGG domain; Region: DRTGG; pfam07085 985002005132 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 985002005133 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 985002005134 active site 2 [active] 985002005135 active site 1 [active] 985002005136 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 985002005137 Ligand Binding Site [chemical binding]; other site 985002005138 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 985002005139 metal-dependent hydrolase; Provisional; Region: PRK00685 985002005140 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 985002005141 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 985002005142 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 985002005143 active site 985002005144 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 985002005145 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 985002005146 hexamer interface [polypeptide binding]; other site 985002005147 ligand binding site [chemical binding]; other site 985002005148 putative active site [active] 985002005149 NAD(P) binding site [chemical binding]; other site 985002005150 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 985002005151 Ligand Binding Site [chemical binding]; other site 985002005152 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 985002005153 propionate/acetate kinase; Provisional; Region: PRK12379 985002005154 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 985002005155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002005156 S-adenosylmethionine binding site [chemical binding]; other site 985002005157 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 985002005158 dimer interface [polypeptide binding]; other site 985002005159 catalytic triad [active] 985002005160 peroxidatic and resolving cysteines [active] 985002005161 hypothetical protein; Provisional; Region: PRK10621 985002005162 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 985002005163 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 985002005164 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 985002005165 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 985002005166 Ligand Binding Site [chemical binding]; other site 985002005167 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 985002005168 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 985002005169 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 985002005170 catalytic residue [active] 985002005171 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 985002005172 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 985002005173 GAF domain; Region: GAF_2; pfam13185 985002005174 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 985002005175 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 985002005176 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 985002005177 RNA binding surface [nucleotide binding]; other site 985002005178 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 985002005179 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 985002005180 active site 985002005181 catalytic site [active] 985002005182 OsmC-like protein; Region: OsmC; cl00767 985002005183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 985002005184 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 985002005185 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 985002005186 catalytic residue [active] 985002005187 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 985002005188 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 985002005189 ligand binding site [chemical binding]; other site 985002005190 NAD binding site [chemical binding]; other site 985002005191 dimerization interface [polypeptide binding]; other site 985002005192 catalytic site [active] 985002005193 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 985002005194 putative L-serine binding site [chemical binding]; other site 985002005195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002005196 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 985002005197 motif II; other site 985002005198 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 985002005199 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 985002005200 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 985002005201 active site turn [active] 985002005202 phosphorylation site [posttranslational modification] 985002005203 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 985002005204 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 985002005205 putative acyl-acceptor binding pocket; other site 985002005206 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 985002005207 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 985002005208 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 985002005209 protein binding site [polypeptide binding]; other site 985002005210 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 985002005211 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 985002005212 active site 985002005213 HIGH motif; other site 985002005214 dimer interface [polypeptide binding]; other site 985002005215 KMSKS motif; other site 985002005216 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 985002005217 RNA binding surface [nucleotide binding]; other site 985002005218 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 985002005219 Transglycosylase; Region: Transgly; pfam00912 985002005220 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 985002005221 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 985002005222 NEAr Transporter domain; Region: NEAT; smart00725 985002005223 NEAr Transporter domain; Region: NEAT; smart00725 985002005224 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 985002005225 heme-binding site [chemical binding]; other site 985002005226 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 985002005227 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 985002005228 Potassium binding sites [ion binding]; other site 985002005229 Cesium cation binding sites [ion binding]; other site 985002005230 acetyl-CoA synthetase; Provisional; Region: PRK04319 985002005231 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 985002005232 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 985002005233 active site 985002005234 acyl-activating enzyme (AAE) consensus motif; other site 985002005235 putative CoA binding site [chemical binding]; other site 985002005236 AMP binding site [chemical binding]; other site 985002005237 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 985002005238 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 985002005239 active site 985002005240 Zn binding site [ion binding]; other site 985002005241 catabolite control protein A; Region: ccpA; TIGR01481 985002005242 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 985002005243 DNA binding site [nucleotide binding] 985002005244 domain linker motif; other site 985002005245 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 985002005246 dimerization interface [polypeptide binding]; other site 985002005247 effector binding site; other site 985002005248 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 985002005249 Chorismate mutase type II; Region: CM_2; cl00693 985002005250 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 985002005251 phosphodiesterase; Provisional; Region: PRK12704 985002005252 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 985002005253 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 985002005254 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 985002005255 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 985002005256 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 985002005257 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 985002005258 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 985002005259 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 985002005260 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 985002005261 putative tRNA-binding site [nucleotide binding]; other site 985002005262 hypothetical protein; Provisional; Region: PRK13668 985002005263 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 985002005264 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 985002005265 catalytic residues [active] 985002005266 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 985002005267 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 985002005268 oligomer interface [polypeptide binding]; other site 985002005269 active site 985002005270 metal binding site [ion binding]; metal-binding site 985002005271 Predicted small secreted protein [Function unknown]; Region: COG5584 985002005272 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 985002005273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002005274 S-adenosylmethionine binding site [chemical binding]; other site 985002005275 Phosphotransferase enzyme family; Region: APH; pfam01636 985002005276 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 985002005277 active site 985002005278 substrate binding site [chemical binding]; other site 985002005279 ATP binding site [chemical binding]; other site 985002005280 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 985002005281 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 985002005282 homodimer interface [polypeptide binding]; other site 985002005283 substrate-cofactor binding pocket; other site 985002005284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002005285 catalytic residue [active] 985002005286 dipeptidase PepV; Reviewed; Region: PRK07318 985002005287 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 985002005288 active site 985002005289 metal binding site [ion binding]; metal-binding site 985002005290 Hsp70 protein; Region: HSP70; pfam00012 985002005291 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 985002005292 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 985002005293 RNA binding surface [nucleotide binding]; other site 985002005294 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 985002005295 active site 985002005296 uracil binding [chemical binding]; other site 985002005297 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 985002005298 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 985002005299 HI0933-like protein; Region: HI0933_like; pfam03486 985002005300 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 985002005301 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 985002005302 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 985002005303 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005304 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005305 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005306 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005307 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005308 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005309 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005310 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005311 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005312 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005313 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005314 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005315 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005316 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005317 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005318 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002005319 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 985002005320 active site residue [active] 985002005321 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 985002005322 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 985002005323 HIGH motif; other site 985002005324 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 985002005325 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 985002005326 active site 985002005327 KMSKS motif; other site 985002005328 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 985002005329 tRNA binding surface [nucleotide binding]; other site 985002005330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002005331 Major Facilitator Superfamily; Region: MFS_1; pfam07690 985002005332 putative substrate translocation pore; other site 985002005333 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 985002005334 Methyltransferase domain; Region: Methyltransf_31; pfam13847 985002005335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002005336 S-adenosylmethionine binding site [chemical binding]; other site 985002005337 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 985002005338 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 985002005339 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 985002005340 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 985002005341 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 985002005342 homopentamer interface [polypeptide binding]; other site 985002005343 active site 985002005344 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 985002005345 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 985002005346 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 985002005347 dimerization interface [polypeptide binding]; other site 985002005348 active site 985002005349 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 985002005350 Lumazine binding domain; Region: Lum_binding; pfam00677 985002005351 Lumazine binding domain; Region: Lum_binding; pfam00677 985002005352 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 985002005353 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 985002005354 catalytic motif [active] 985002005355 Zn binding site [ion binding]; other site 985002005356 RibD C-terminal domain; Region: RibD_C; cl17279 985002005357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 985002005358 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 985002005359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 985002005360 dimerization interface [polypeptide binding]; other site 985002005361 putative DNA binding site [nucleotide binding]; other site 985002005362 putative Zn2+ binding site [ion binding]; other site 985002005363 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 985002005364 arsenical pump membrane protein; Provisional; Region: PRK15445 985002005365 transmembrane helices; other site 985002005366 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 985002005367 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 985002005368 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 985002005369 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 985002005370 DNA binding residues [nucleotide binding] 985002005371 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 985002005372 anion exchange protein; Region: ae; TIGR00834 985002005373 CAAX protease self-immunity; Region: Abi; pfam02517 985002005374 CAAX protease self-immunity; Region: Abi; pfam02517 985002005375 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 985002005376 active site 985002005377 intersubunit interactions; other site 985002005378 catalytic residue [active] 985002005379 camphor resistance protein CrcB; Provisional; Region: PRK14201 985002005380 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 985002005381 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 985002005382 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 985002005383 active site 985002005384 catalytic tetrad [active] 985002005385 S-adenosylmethionine synthetase; Validated; Region: PRK05250 985002005386 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 985002005387 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 985002005388 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 985002005389 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 985002005390 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 985002005391 active site 985002005392 substrate-binding site [chemical binding]; other site 985002005393 metal-binding site [ion binding] 985002005394 ATP binding site [chemical binding]; other site 985002005395 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 985002005396 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 985002005397 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 985002005398 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 985002005399 nudix motif; other site 985002005400 Haemolytic domain; Region: Haemolytic; pfam01809 985002005401 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 985002005402 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 985002005403 metal binding site [ion binding]; metal-binding site 985002005404 substrate binding pocket [chemical binding]; other site 985002005405 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 985002005406 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 985002005407 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 985002005408 acyl-activating enzyme (AAE) consensus motif; other site 985002005409 putative AMP binding site [chemical binding]; other site 985002005410 putative active site [active] 985002005411 putative CoA binding site [chemical binding]; other site 985002005412 Excalibur calcium-binding domain; Region: Excalibur; smart00894 985002005413 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 985002005414 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 985002005415 Domain of unknown function (DUF955); Region: DUF955; pfam06114 985002005416 genomic island niSa-beta 985002005417 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 985002005418 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 985002005419 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 985002005420 nucleophilic elbow; other site 985002005421 catalytic triad; other site 985002005422 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 985002005423 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 985002005424 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 985002005425 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 985002005426 HsdM N-terminal domain; Region: HsdM_N; pfam12161 985002005427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002005428 S-adenosylmethionine binding site [chemical binding]; other site 985002005429 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 985002005430 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 985002005431 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 985002005432 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 985002005433 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 985002005434 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 985002005435 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 985002005436 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 985002005437 active site 985002005438 Int/Topo IB signature motif; other site 985002005439 DNA binding site [nucleotide binding] 985002005440 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 985002005441 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002005442 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 985002005443 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002005444 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 985002005445 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002005446 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 985002005447 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002005448 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 985002005449 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002005450 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 985002005451 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 985002005452 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 985002005453 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 985002005454 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 985002005455 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 985002005456 ferrochelatase; Provisional; Region: PRK12435 985002005457 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 985002005458 C-terminal domain interface [polypeptide binding]; other site 985002005459 active site 985002005460 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 985002005461 active site 985002005462 N-terminal domain interface [polypeptide binding]; other site 985002005463 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 985002005464 substrate binding site [chemical binding]; other site 985002005465 active site 985002005466 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 985002005467 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 985002005468 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 985002005469 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 985002005470 Walker A/P-loop; other site 985002005471 ATP binding site [chemical binding]; other site 985002005472 Q-loop/lid; other site 985002005473 ABC transporter signature motif; other site 985002005474 Walker B; other site 985002005475 D-loop; other site 985002005476 H-loop/switch region; other site 985002005477 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 985002005478 HIT family signature motif; other site 985002005479 catalytic residue [active] 985002005480 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 985002005481 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 985002005482 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 985002005483 SurA N-terminal domain; Region: SurA_N_3; cl07813 985002005484 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 985002005485 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 985002005486 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 985002005487 generic binding surface II; other site 985002005488 generic binding surface I; other site 985002005489 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 985002005490 Zn2+ binding site [ion binding]; other site 985002005491 Mg2+ binding site [ion binding]; other site 985002005492 Uncharacterized conserved protein [Function unknown]; Region: COG4717 985002005493 P-loop containing region of AAA domain; Region: AAA_29; cl17516 985002005494 SdpI/YhfL protein family; Region: SdpI; pfam13630 985002005495 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 985002005496 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 985002005497 active site 985002005498 metal binding site [ion binding]; metal-binding site 985002005499 DNA binding site [nucleotide binding] 985002005500 hypothetical protein; Provisional; Region: PRK13676 985002005501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 985002005502 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 985002005503 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 985002005504 non-specific DNA binding site [nucleotide binding]; other site 985002005505 salt bridge; other site 985002005506 sequence-specific DNA binding site [nucleotide binding]; other site 985002005507 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 985002005508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002005509 active site 985002005510 phosphorylation site [posttranslational modification] 985002005511 intermolecular recognition site; other site 985002005512 dimerization interface [polypeptide binding]; other site 985002005513 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 985002005514 DNA binding residues [nucleotide binding] 985002005515 dimerization interface [polypeptide binding]; other site 985002005516 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 985002005517 GAF domain; Region: GAF_3; pfam13492 985002005518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 985002005519 Histidine kinase; Region: HisKA_3; pfam07730 985002005520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002005521 ATP binding site [chemical binding]; other site 985002005522 Mg2+ binding site [ion binding]; other site 985002005523 G-X-G motif; other site 985002005524 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 985002005525 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 985002005526 active site 985002005527 fumarate hydratase; Reviewed; Region: fumC; PRK00485 985002005528 Class II fumarases; Region: Fumarase_classII; cd01362 985002005529 active site 985002005530 tetramer interface [polypeptide binding]; other site 985002005531 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 985002005532 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 985002005533 active site 985002005534 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 985002005535 epoxyqueuosine reductase; Region: TIGR00276 985002005536 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 985002005537 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 985002005538 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 985002005539 Walker A/P-loop; other site 985002005540 ATP binding site [chemical binding]; other site 985002005541 Q-loop/lid; other site 985002005542 ABC transporter signature motif; other site 985002005543 Walker B; other site 985002005544 D-loop; other site 985002005545 H-loop/switch region; other site 985002005546 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 985002005547 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 985002005548 substrate binding pocket [chemical binding]; other site 985002005549 membrane-bound complex binding site; other site 985002005550 hinge residues; other site 985002005551 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 985002005552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002005553 dimer interface [polypeptide binding]; other site 985002005554 conserved gate region; other site 985002005555 putative PBP binding loops; other site 985002005556 ABC-ATPase subunit interface; other site 985002005557 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 985002005558 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 985002005559 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 985002005560 metal binding site 2 [ion binding]; metal-binding site 985002005561 putative DNA binding helix; other site 985002005562 metal binding site 1 [ion binding]; metal-binding site 985002005563 dimer interface [polypeptide binding]; other site 985002005564 structural Zn2+ binding site [ion binding]; other site 985002005565 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 985002005566 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 985002005567 putative ligand binding site [chemical binding]; other site 985002005568 NAD binding site [chemical binding]; other site 985002005569 catalytic site [active] 985002005570 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 985002005571 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 985002005572 catalytic triad [active] 985002005573 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 985002005574 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 985002005575 inhibitor-cofactor binding pocket; inhibition site 985002005576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002005577 catalytic residue [active] 985002005578 Predicted membrane protein [Function unknown]; Region: COG4129 985002005579 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 985002005580 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 985002005581 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 985002005582 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 985002005583 Walker A/P-loop; other site 985002005584 ATP binding site [chemical binding]; other site 985002005585 Q-loop/lid; other site 985002005586 ABC transporter signature motif; other site 985002005587 Walker B; other site 985002005588 D-loop; other site 985002005589 H-loop/switch region; other site 985002005590 hypothetical protein; Provisional; Region: PRK13662 985002005591 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 985002005592 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 985002005593 minor groove reading motif; other site 985002005594 helix-hairpin-helix signature motif; other site 985002005595 substrate binding pocket [chemical binding]; other site 985002005596 active site 985002005597 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 985002005598 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 985002005599 DNA binding and oxoG recognition site [nucleotide binding] 985002005600 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 985002005601 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 985002005602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 985002005603 Walker A/P-loop; other site 985002005604 ATP binding site [chemical binding]; other site 985002005605 Q-loop/lid; other site 985002005606 ABC transporter signature motif; other site 985002005607 Walker B; other site 985002005608 H-loop/switch region; other site 985002005609 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 985002005610 recombination regulator RecX; Provisional; Region: recX; PRK14135 985002005611 glycosyltransferase; Provisional; Region: PRK13481 985002005612 Transglycosylase; Region: Transgly; pfam00912 985002005613 intracellular protease, PfpI family; Region: PfpI; TIGR01382 985002005614 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 985002005615 proposed catalytic triad [active] 985002005616 conserved cys residue [active] 985002005617 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 985002005618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 985002005619 FeS/SAM binding site; other site 985002005620 YfkB-like domain; Region: YfkB; pfam08756 985002005621 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 985002005622 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 985002005623 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 985002005624 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 985002005625 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 985002005626 Low molecular weight phosphatase family; Region: LMWPc; cd00115 985002005627 active site 985002005628 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 985002005629 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 985002005630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002005631 active site 985002005632 phosphorylation site [posttranslational modification] 985002005633 intermolecular recognition site; other site 985002005634 dimerization interface [polypeptide binding]; other site 985002005635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 985002005636 DNA binding residues [nucleotide binding] 985002005637 dimerization interface [polypeptide binding]; other site 985002005638 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 985002005639 Histidine kinase; Region: HisKA_3; pfam07730 985002005640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002005641 ATP binding site [chemical binding]; other site 985002005642 Mg2+ binding site [ion binding]; other site 985002005643 G-X-G motif; other site 985002005644 Predicted membrane protein [Function unknown]; Region: COG4758 985002005645 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 985002005646 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 985002005647 active site 985002005648 Predicted membrane protein [Function unknown]; Region: COG4129 985002005649 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 985002005650 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 985002005651 catalytic triad [active] 985002005652 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 985002005653 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 985002005654 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 985002005655 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 985002005656 Ferritin-like domain; Region: Ferritin; pfam00210 985002005657 ferroxidase diiron center [ion binding]; other site 985002005658 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 985002005659 catalytic triad [active] 985002005660 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 985002005661 active site 985002005662 catalytic site [active] 985002005663 substrate binding site [chemical binding]; other site 985002005664 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 985002005665 active site 985002005666 DNA polymerase IV; Validated; Region: PRK02406 985002005667 DNA binding site [nucleotide binding] 985002005668 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 985002005669 TRAM domain; Region: TRAM; cl01282 985002005670 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 985002005671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002005672 S-adenosylmethionine binding site [chemical binding]; other site 985002005673 putative lipid kinase; Reviewed; Region: PRK13337 985002005674 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 985002005675 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 985002005676 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 985002005677 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 985002005678 GatB domain; Region: GatB_Yqey; pfam02637 985002005679 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 985002005680 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 985002005681 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 985002005682 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 985002005683 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 985002005684 Na binding site [ion binding]; other site 985002005685 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 985002005686 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 985002005687 putative dimer interface [polypeptide binding]; other site 985002005688 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 985002005689 putative dimer interface [polypeptide binding]; other site 985002005690 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 985002005691 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 985002005692 nucleotide binding pocket [chemical binding]; other site 985002005693 K-X-D-G motif; other site 985002005694 catalytic site [active] 985002005695 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 985002005696 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 985002005697 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 985002005698 Dimer interface [polypeptide binding]; other site 985002005699 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 985002005700 Part of AAA domain; Region: AAA_19; pfam13245 985002005701 Family description; Region: UvrD_C_2; pfam13538 985002005702 PcrB family; Region: PcrB; pfam01884 985002005703 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 985002005704 substrate binding site [chemical binding]; other site 985002005705 putative active site [active] 985002005706 dimer interface [polypeptide binding]; other site 985002005707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 985002005708 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 985002005709 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 985002005710 tetramer interface [polypeptide binding]; other site 985002005711 active site 985002005712 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 985002005713 NETI protein; Region: NETI; pfam14044 985002005714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 985002005715 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 985002005716 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 985002005717 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 985002005718 homodimer interface [polypeptide binding]; other site 985002005719 NAD binding pocket [chemical binding]; other site 985002005720 ATP binding pocket [chemical binding]; other site 985002005721 Mg binding site [ion binding]; other site 985002005722 active-site loop [active] 985002005723 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 985002005724 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 985002005725 active site 985002005726 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 985002005727 active site 985002005728 dimer interface [polypeptide binding]; other site 985002005729 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 985002005730 Prephenate dehydratase; Region: PDT; pfam00800 985002005731 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 985002005732 putative L-Phe binding site [chemical binding]; other site 985002005733 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 985002005734 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 985002005735 transmembrane helices; other site 985002005736 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 985002005737 Isochorismatase family; Region: Isochorismatase; pfam00857 985002005738 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 985002005739 catalytic triad [active] 985002005740 conserved cis-peptide bond; other site 985002005741 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 985002005742 DHH family; Region: DHH; pfam01368 985002005743 DHHA2 domain; Region: DHHA2; pfam02833 985002005744 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 985002005745 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 985002005746 NAD(P) binding site [chemical binding]; other site 985002005747 catalytic residues [active] 985002005748 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 985002005749 YolD-like protein; Region: YolD; pfam08863 985002005750 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 985002005751 active site 985002005752 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 985002005753 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 985002005754 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 985002005755 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 985002005756 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 985002005757 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 985002005758 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 985002005759 Walker A/P-loop; other site 985002005760 ATP binding site [chemical binding]; other site 985002005761 Q-loop/lid; other site 985002005762 ABC transporter signature motif; other site 985002005763 Walker B; other site 985002005764 D-loop; other site 985002005765 H-loop/switch region; other site 985002005766 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 985002005767 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 985002005768 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 985002005769 Walker A/P-loop; other site 985002005770 ATP binding site [chemical binding]; other site 985002005771 Q-loop/lid; other site 985002005772 ABC transporter signature motif; other site 985002005773 Walker B; other site 985002005774 D-loop; other site 985002005775 H-loop/switch region; other site 985002005776 Predicted transcriptional regulators [Transcription]; Region: COG1725 985002005777 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 985002005778 DNA-binding site [nucleotide binding]; DNA binding site 985002005779 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 985002005780 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 985002005781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002005782 homodimer interface [polypeptide binding]; other site 985002005783 catalytic residue [active] 985002005784 MAP domain; Region: MAP; pfam03642 985002005785 MAP domain; Region: MAP; pfam03642 985002005786 MAP domain; Region: MAP; pfam03642 985002005787 MAP domain; Region: MAP; pfam03642 985002005788 Prophage 985002005789 Bacterial SH3 domain homologues; Region: SH3b; smart00287 985002005790 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 985002005791 CHAP domain; Region: CHAP; pfam05257 985002005792 Small integral membrane protein [Function unknown]; Region: COG5546 985002005793 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 985002005794 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 985002005795 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 985002005796 Phage tail protein; Region: Sipho_tail; cl17486 985002005797 Phage tail protein; Region: Sipho_tail; cl17486 985002005798 Phage-related minor tail protein [Function unknown]; Region: COG5280 985002005799 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 985002005800 Phage-related protein [Function unknown]; Region: COG5412 985002005801 membrane protein P6; Region: PHA01399 985002005802 Peptidase family M23; Region: Peptidase_M23; pfam01551 985002005803 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 985002005804 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 985002005805 N-acetyl-D-glucosamine binding site [chemical binding]; other site 985002005806 catalytic residue [active] 985002005807 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 985002005808 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 985002005809 SacI homology domain; Region: Syja_N; pfam02383 985002005810 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 985002005811 Clp protease; Region: CLP_protease; pfam00574 985002005812 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 985002005813 oligomer interface [polypeptide binding]; other site 985002005814 active site residues [active] 985002005815 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 985002005816 Phage-related protein [Function unknown]; Region: COG4695; cl01923 985002005817 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 985002005818 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 985002005819 HNH endonuclease; Region: HNH; pfam01844 985002005820 active site 985002005821 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 985002005822 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 985002005823 Transcriptional activator RinB; Region: RinB; pfam06116 985002005824 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 985002005825 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 985002005826 trimer interface [polypeptide binding]; other site 985002005827 active site 985002005828 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 985002005829 YopX protein; Region: YopX; cl09859 985002005830 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 985002005831 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 985002005832 Endodeoxyribonuclease RusA; Region: RusA; cl01885 985002005833 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 985002005834 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 985002005835 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 985002005836 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 985002005837 dimer interface [polypeptide binding]; other site 985002005838 ssDNA binding site [nucleotide binding]; other site 985002005839 tetramer (dimer of dimers) interface [polypeptide binding]; other site 985002005840 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 985002005841 RecT family; Region: RecT; pfam03837 985002005842 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 985002005843 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 985002005844 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 985002005845 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 985002005846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 985002005847 AntA/AntB antirepressor; Region: AntA; cl01430 985002005848 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 985002005849 Protein of unknown function (DUF739); Region: DUF739; pfam05339 985002005850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 985002005851 non-specific DNA binding site [nucleotide binding]; other site 985002005852 salt bridge; other site 985002005853 sequence-specific DNA binding site [nucleotide binding]; other site 985002005854 Predicted transcriptional regulator [Transcription]; Region: COG2932 985002005855 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 985002005856 Catalytic site [active] 985002005857 PemK-like protein; Region: PemK; pfam02452 985002005858 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 985002005859 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 985002005860 Int/Topo IB signature motif; other site 985002005861 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 985002005862 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 985002005863 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 985002005864 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 985002005865 metal binding site [ion binding]; metal-binding site 985002005866 dimer interface [polypeptide binding]; other site 985002005867 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 985002005868 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 985002005869 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 985002005870 ring oligomerisation interface [polypeptide binding]; other site 985002005871 ATP/Mg binding site [chemical binding]; other site 985002005872 stacking interactions; other site 985002005873 hinge regions; other site 985002005874 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 985002005875 oligomerisation interface [polypeptide binding]; other site 985002005876 mobile loop; other site 985002005877 roof hairpin; other site 985002005878 CAAX protease self-immunity; Region: Abi; pfam02517 985002005879 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 985002005880 dimer interface [polypeptide binding]; other site 985002005881 FMN binding site [chemical binding]; other site 985002005882 Predicted amidohydrolase [General function prediction only]; Region: COG0388 985002005883 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 985002005884 putative active site [active] 985002005885 catalytic triad [active] 985002005886 putative dimer interface [polypeptide binding]; other site 985002005887 delta-hemolysin; Provisional; Region: PRK14752 985002005888 Accessory gene regulator B; Region: AgrB; smart00793 985002005889 Staphylococcal AgrD protein; Region: AgrD; smart00794 985002005890 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 985002005891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002005892 Mg2+ binding site [ion binding]; other site 985002005893 G-X-G motif; other site 985002005894 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 985002005895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002005896 active site 985002005897 phosphorylation site [posttranslational modification] 985002005898 intermolecular recognition site; other site 985002005899 dimerization interface [polypeptide binding]; other site 985002005900 LytTr DNA-binding domain; Region: LytTR; pfam04397 985002005901 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 985002005902 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 985002005903 putative substrate binding site [chemical binding]; other site 985002005904 putative ATP binding site [chemical binding]; other site 985002005905 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 985002005906 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 985002005907 substrate binding [chemical binding]; other site 985002005908 active site 985002005909 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 985002005910 Transcriptional regulators [Transcription]; Region: PurR; COG1609 985002005911 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 985002005912 DNA binding site [nucleotide binding] 985002005913 domain linker motif; other site 985002005914 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 985002005915 dimerization interface [polypeptide binding]; other site 985002005916 ligand binding site [chemical binding]; other site 985002005917 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 985002005918 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 985002005919 CPxP motif; other site 985002005920 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 985002005921 Sulphur transport; Region: Sulf_transp; pfam04143 985002005922 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 985002005923 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 985002005924 CoA binding domain; Region: CoA_binding; pfam02629 985002005925 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 985002005926 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 985002005927 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 985002005928 ABC transporter; Region: ABC_tran_2; pfam12848 985002005929 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 985002005930 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 985002005931 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 985002005932 Walker A/P-loop; other site 985002005933 ATP binding site [chemical binding]; other site 985002005934 Q-loop/lid; other site 985002005935 ABC transporter signature motif; other site 985002005936 Walker B; other site 985002005937 D-loop; other site 985002005938 H-loop/switch region; other site 985002005939 UGMP family protein; Validated; Region: PRK09604 985002005940 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 985002005941 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 985002005942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002005943 Coenzyme A binding pocket [chemical binding]; other site 985002005944 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 985002005945 Glycoprotease family; Region: Peptidase_M22; pfam00814 985002005946 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 985002005947 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 985002005948 6-phosphogluconate dehydratase; Region: edd; TIGR01196 985002005949 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 985002005950 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 985002005951 PYR/PP interface [polypeptide binding]; other site 985002005952 dimer interface [polypeptide binding]; other site 985002005953 TPP binding site [chemical binding]; other site 985002005954 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 985002005955 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 985002005956 TPP-binding site [chemical binding]; other site 985002005957 dimer interface [polypeptide binding]; other site 985002005958 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 985002005959 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 985002005960 ketol-acid reductoisomerase; Provisional; Region: PRK05479 985002005961 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 985002005962 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 985002005963 2-isopropylmalate synthase; Validated; Region: PRK00915 985002005964 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 985002005965 active site 985002005966 catalytic residues [active] 985002005967 metal binding site [ion binding]; metal-binding site 985002005968 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 985002005969 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 985002005970 tartrate dehydrogenase; Region: TTC; TIGR02089 985002005971 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 985002005972 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 985002005973 substrate binding site [chemical binding]; other site 985002005974 ligand binding site [chemical binding]; other site 985002005975 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 985002005976 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 985002005977 substrate binding site [chemical binding]; other site 985002005978 threonine dehydratase; Validated; Region: PRK08639 985002005979 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 985002005980 tetramer interface [polypeptide binding]; other site 985002005981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002005982 catalytic residue [active] 985002005983 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 985002005984 putative Ile/Val binding site [chemical binding]; other site 985002005985 hypothetical protein; Provisional; Region: PRK04351 985002005986 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 985002005987 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 985002005988 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 985002005989 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 985002005990 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 985002005991 RNA binding site [nucleotide binding]; other site 985002005992 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 985002005993 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 985002005994 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 985002005995 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 985002005996 DNA binding residues [nucleotide binding] 985002005997 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 985002005998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002005999 ATP binding site [chemical binding]; other site 985002006000 Mg2+ binding site [ion binding]; other site 985002006001 G-X-G motif; other site 985002006002 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 985002006003 anti sigma factor interaction site; other site 985002006004 regulatory phosphorylation site [posttranslational modification]; other site 985002006005 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 985002006006 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 985002006007 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 985002006008 PemK-like protein; Region: PemK; pfam02452 985002006009 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 985002006010 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 985002006011 active site 985002006012 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 985002006013 dimer interface [polypeptide binding]; other site 985002006014 substrate binding site [chemical binding]; other site 985002006015 catalytic residues [active] 985002006016 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 985002006017 Uncharacterized conserved protein [Function unknown]; Region: COG3402 985002006018 Predicted membrane protein [Function unknown]; Region: COG3428 985002006019 Bacterial PH domain; Region: DUF304; pfam03703 985002006020 Bacterial PH domain; Region: DUF304; pfam03703 985002006021 Bacterial PH domain; Region: DUF304; cl01348 985002006022 K+-transporting ATPase, c chain; Region: KdpC; cl00944 985002006023 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 985002006024 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 985002006025 Soluble P-type ATPase [General function prediction only]; Region: COG4087 985002006026 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 985002006027 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 985002006028 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 985002006029 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 985002006030 Ligand Binding Site [chemical binding]; other site 985002006031 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 985002006032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 985002006033 dimer interface [polypeptide binding]; other site 985002006034 phosphorylation site [posttranslational modification] 985002006035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002006036 ATP binding site [chemical binding]; other site 985002006037 Mg2+ binding site [ion binding]; other site 985002006038 G-X-G motif; other site 985002006039 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 985002006040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002006041 active site 985002006042 phosphorylation site [posttranslational modification] 985002006043 intermolecular recognition site; other site 985002006044 dimerization interface [polypeptide binding]; other site 985002006045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 985002006046 DNA binding site [nucleotide binding] 985002006047 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 985002006048 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 985002006049 ATP binding site [chemical binding]; other site 985002006050 Mg++ binding site [ion binding]; other site 985002006051 motif III; other site 985002006052 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 985002006053 nucleotide binding region [chemical binding]; other site 985002006054 ATP-binding site [chemical binding]; other site 985002006055 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 985002006056 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 985002006057 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 985002006058 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 985002006059 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 985002006060 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 985002006061 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 985002006062 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 985002006063 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 985002006064 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 985002006065 putative homodimer interface [polypeptide binding]; other site 985002006066 putative homotetramer interface [polypeptide binding]; other site 985002006067 allosteric switch controlling residues; other site 985002006068 putative metal binding site [ion binding]; other site 985002006069 putative homodimer-homodimer interface [polypeptide binding]; other site 985002006070 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 985002006071 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 985002006072 putative active site [active] 985002006073 catalytic site [active] 985002006074 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 985002006075 putative active site [active] 985002006076 catalytic site [active] 985002006077 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 985002006078 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 985002006079 Zn2+ binding site [ion binding]; other site 985002006080 Mg2+ binding site [ion binding]; other site 985002006081 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 985002006082 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 985002006083 thiamine phosphate binding site [chemical binding]; other site 985002006084 active site 985002006085 pyrophosphate binding site [ion binding]; other site 985002006086 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 985002006087 substrate binding site [chemical binding]; other site 985002006088 multimerization interface [polypeptide binding]; other site 985002006089 ATP binding site [chemical binding]; other site 985002006090 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 985002006091 dimer interface [polypeptide binding]; other site 985002006092 substrate binding site [chemical binding]; other site 985002006093 ATP binding site [chemical binding]; other site 985002006094 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 985002006095 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 985002006096 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 985002006097 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 985002006098 dimer interface [polypeptide binding]; other site 985002006099 ssDNA binding site [nucleotide binding]; other site 985002006100 tetramer (dimer of dimers) interface [polypeptide binding]; other site 985002006101 YwpF-like protein; Region: YwpF; pfam14183 985002006102 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 985002006103 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 985002006104 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 985002006105 hinge; other site 985002006106 active site 985002006107 Predicted membrane protein [Function unknown]; Region: COG4836 985002006108 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 985002006109 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 985002006110 gamma subunit interface [polypeptide binding]; other site 985002006111 epsilon subunit interface [polypeptide binding]; other site 985002006112 LBP interface [polypeptide binding]; other site 985002006113 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 985002006114 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 985002006115 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 985002006116 alpha subunit interaction interface [polypeptide binding]; other site 985002006117 Walker A motif; other site 985002006118 ATP binding site [chemical binding]; other site 985002006119 Walker B motif; other site 985002006120 inhibitor binding site; inhibition site 985002006121 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 985002006122 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 985002006123 core domain interface [polypeptide binding]; other site 985002006124 delta subunit interface [polypeptide binding]; other site 985002006125 epsilon subunit interface [polypeptide binding]; other site 985002006126 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 985002006127 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 985002006128 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 985002006129 beta subunit interaction interface [polypeptide binding]; other site 985002006130 Walker A motif; other site 985002006131 ATP binding site [chemical binding]; other site 985002006132 Walker B motif; other site 985002006133 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 985002006134 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 985002006135 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 985002006136 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 985002006137 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 985002006138 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 985002006139 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 985002006140 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 985002006141 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 985002006142 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 985002006143 active site 985002006144 homodimer interface [polypeptide binding]; other site 985002006145 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 985002006146 active site 985002006147 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 985002006148 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 985002006149 dimer interface [polypeptide binding]; other site 985002006150 active site 985002006151 glycine-pyridoxal phosphate binding site [chemical binding]; other site 985002006152 folate binding site [chemical binding]; other site 985002006153 hypothetical protein; Provisional; Region: PRK13690 985002006154 Low molecular weight phosphatase family; Region: LMWPc; cd00115 985002006155 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 985002006156 active site 985002006157 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 985002006158 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 985002006159 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 985002006160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002006161 S-adenosylmethionine binding site [chemical binding]; other site 985002006162 peptide chain release factor 1; Validated; Region: prfA; PRK00591 985002006163 This domain is found in peptide chain release factors; Region: PCRF; smart00937 985002006164 RF-1 domain; Region: RF-1; pfam00472 985002006165 thymidine kinase; Provisional; Region: PRK04296 985002006166 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 985002006167 transcription termination factor Rho; Provisional; Region: rho; PRK09376 985002006168 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 985002006169 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 985002006170 RNA binding site [nucleotide binding]; other site 985002006171 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 985002006172 multimer interface [polypeptide binding]; other site 985002006173 Walker A motif; other site 985002006174 ATP binding site [chemical binding]; other site 985002006175 Walker B motif; other site 985002006176 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 985002006177 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 985002006178 NAD binding site [chemical binding]; other site 985002006179 catalytic residues [active] 985002006180 Predicted transcriptional regulators [Transcription]; Region: COG1733 985002006181 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 985002006182 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 985002006183 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 985002006184 hinge; other site 985002006185 active site 985002006186 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 985002006187 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 985002006188 intersubunit interface [polypeptide binding]; other site 985002006189 active site 985002006190 zinc binding site [ion binding]; other site 985002006191 Na+ binding site [ion binding]; other site 985002006192 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 985002006193 CTP synthetase; Validated; Region: pyrG; PRK05380 985002006194 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 985002006195 Catalytic site [active] 985002006196 active site 985002006197 UTP binding site [chemical binding]; other site 985002006198 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 985002006199 active site 985002006200 putative oxyanion hole; other site 985002006201 catalytic triad [active] 985002006202 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 985002006203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002006204 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 985002006205 Coenzyme A binding pocket [chemical binding]; other site 985002006206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 985002006207 Coenzyme A binding pocket [chemical binding]; other site 985002006208 pantothenate kinase; Provisional; Region: PRK13317 985002006209 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 985002006210 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 985002006211 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 985002006212 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 985002006213 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 985002006214 metal binding site [ion binding]; metal-binding site 985002006215 S-ribosylhomocysteinase; Provisional; Region: PRK02260 985002006216 Predicted membrane protein [Function unknown]; Region: COG4270 985002006217 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 985002006218 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 985002006219 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 985002006220 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 985002006221 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 985002006222 intersubunit interface [polypeptide binding]; other site 985002006223 active site 985002006224 catalytic residue [active] 985002006225 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 985002006226 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 985002006227 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 985002006228 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 985002006229 dimerization interface [polypeptide binding]; other site 985002006230 DPS ferroxidase diiron center [ion binding]; other site 985002006231 ion pore; other site 985002006232 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 985002006233 EVE domain; Region: EVE; cl00728 985002006234 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 985002006235 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 985002006236 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 985002006237 NADH(P)-binding; Region: NAD_binding_10; pfam13460 985002006238 NAD(P) binding site [chemical binding]; other site 985002006239 putative active site [active] 985002006240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 985002006241 dimerization interface [polypeptide binding]; other site 985002006242 putative DNA binding site [nucleotide binding]; other site 985002006243 putative Zn2+ binding site [ion binding]; other site 985002006244 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 985002006245 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 985002006246 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 985002006247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002006248 active site 985002006249 motif I; other site 985002006250 motif II; other site 985002006251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002006252 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 985002006253 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 985002006254 Walker A/P-loop; other site 985002006255 ATP binding site [chemical binding]; other site 985002006256 Q-loop/lid; other site 985002006257 ABC transporter signature motif; other site 985002006258 Walker B; other site 985002006259 D-loop; other site 985002006260 H-loop/switch region; other site 985002006261 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 985002006262 TIR domain; Region: TIR_2; pfam13676 985002006263 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 985002006264 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 985002006265 Helix-turn-helix domain; Region: HTH_38; pfam13936 985002006266 AAA domain; Region: AAA_22; pfam13401 985002006267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 985002006268 Transposase; Region: DDE_Tnp_ISL3; pfam01610 985002006269 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 985002006270 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 985002006271 glutaminase active site [active] 985002006272 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 985002006273 dimer interface [polypeptide binding]; other site 985002006274 active site 985002006275 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 985002006276 dimer interface [polypeptide binding]; other site 985002006277 active site 985002006278 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 985002006279 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 985002006280 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 985002006281 active site 985002006282 P-loop; other site 985002006283 phosphorylation site [posttranslational modification] 985002006284 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 985002006285 HTH domain; Region: HTH_11; pfam08279 985002006286 PRD domain; Region: PRD; pfam00874 985002006287 PRD domain; Region: PRD; pfam00874 985002006288 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 985002006289 active site 985002006290 P-loop; other site 985002006291 phosphorylation site [posttranslational modification] 985002006292 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 985002006293 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 985002006294 active site 985002006295 phosphorylation site [posttranslational modification] 985002006296 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 985002006297 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 985002006298 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 985002006299 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 985002006300 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 985002006301 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002006302 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002006303 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002006304 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002006305 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002006306 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002006307 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002006308 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002006309 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002006310 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002006311 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 985002006312 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 985002006313 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 985002006314 active site 985002006315 substrate binding site [chemical binding]; other site 985002006316 metal binding site [ion binding]; metal-binding site 985002006317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 985002006318 YbbR-like protein; Region: YbbR; pfam07949 985002006319 YbbR-like protein; Region: YbbR; pfam07949 985002006320 TIGR00159 family protein; Region: TIGR00159 985002006321 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 985002006322 Arginase family; Region: Arginase; cd09989 985002006323 agmatinase; Region: agmatinase; TIGR01230 985002006324 active site 985002006325 Mn binding site [ion binding]; other site 985002006326 oligomer interface [polypeptide binding]; other site 985002006327 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 985002006328 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 985002006329 Walker A motif; other site 985002006330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002006331 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 985002006332 putative substrate translocation pore; other site 985002006333 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 985002006334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002006335 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 985002006336 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 985002006337 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 985002006338 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 985002006339 substrate binding site; other site 985002006340 dimerization interface; other site 985002006341 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 985002006342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 985002006343 Nucleoside recognition; Region: Gate; pfam07670 985002006344 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 985002006345 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 985002006346 ABC-ATPase subunit interface; other site 985002006347 dimer interface [polypeptide binding]; other site 985002006348 putative PBP binding regions; other site 985002006349 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 985002006350 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 985002006351 ABC-ATPase subunit interface; other site 985002006352 dimer interface [polypeptide binding]; other site 985002006353 putative PBP binding regions; other site 985002006354 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 985002006355 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 985002006356 siderophore binding site; other site 985002006357 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 985002006358 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 985002006359 dimer interface [polypeptide binding]; other site 985002006360 active site 985002006361 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 985002006362 substrate binding site [chemical binding]; other site 985002006363 catalytic residue [active] 985002006364 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 985002006365 IucA / IucC family; Region: IucA_IucC; pfam04183 985002006366 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 985002006367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002006368 putative substrate translocation pore; other site 985002006369 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 985002006370 IucA / IucC family; Region: IucA_IucC; pfam04183 985002006371 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 985002006372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 985002006373 Small integral membrane protein [Function unknown]; Region: COG5547 985002006374 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 985002006375 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 985002006376 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 985002006377 putative NAD(P) binding site [chemical binding]; other site 985002006378 dimer interface [polypeptide binding]; other site 985002006379 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 985002006380 Prostaglandin dehydrogenases; Region: PGDH; cd05288 985002006381 NAD(P) binding site [chemical binding]; other site 985002006382 substrate binding site [chemical binding]; other site 985002006383 dimer interface [polypeptide binding]; other site 985002006384 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 985002006385 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 985002006386 beta-galactosidase; Region: BGL; TIGR03356 985002006387 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 985002006388 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 985002006389 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 985002006390 active site 985002006391 P-loop; other site 985002006392 phosphorylation site [posttranslational modification] 985002006393 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 985002006394 methionine cluster; other site 985002006395 active site 985002006396 phosphorylation site [posttranslational modification] 985002006397 metal binding site [ion binding]; metal-binding site 985002006398 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 985002006399 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 985002006400 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 985002006401 putative substrate binding site [chemical binding]; other site 985002006402 putative ATP binding site [chemical binding]; other site 985002006403 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 985002006404 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 985002006405 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 985002006406 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 985002006407 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 985002006408 NAD-dependent deacetylase; Provisional; Region: PRK00481 985002006409 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 985002006410 NAD+ binding site [chemical binding]; other site 985002006411 substrate binding site [chemical binding]; other site 985002006412 putative Zn binding site [ion binding]; other site 985002006413 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 985002006414 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 985002006415 active site 985002006416 catalytic tetrad [active] 985002006417 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 985002006418 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 985002006419 DNA binding residues [nucleotide binding] 985002006420 putative dimer interface [polypeptide binding]; other site 985002006421 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 985002006422 substrate binding site [chemical binding]; other site 985002006423 catalytic residues [active] 985002006424 Predicted transcriptional regulator [Transcription]; Region: COG2378 985002006425 HTH domain; Region: HTH_11; pfam08279 985002006426 WYL domain; Region: WYL; pfam13280 985002006427 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 985002006428 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 985002006429 conserved cys residue [active] 985002006430 MAP domain; Region: MAP; pfam03642 985002006431 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 985002006432 acetolactate synthase; Reviewed; Region: PRK08617 985002006433 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 985002006434 PYR/PP interface [polypeptide binding]; other site 985002006435 dimer interface [polypeptide binding]; other site 985002006436 TPP binding site [chemical binding]; other site 985002006437 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 985002006438 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 985002006439 TPP-binding site [chemical binding]; other site 985002006440 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 985002006441 Family description; Region: UvrD_C_2; pfam13538 985002006442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 985002006443 Walker A/P-loop; other site 985002006444 ATP binding site [chemical binding]; other site 985002006445 hypothetical protein; Provisional; Region: PRK10281 985002006446 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 985002006447 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 985002006448 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 985002006449 23S rRNA interface [nucleotide binding]; other site 985002006450 L3 interface [polypeptide binding]; other site 985002006451 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 985002006452 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 985002006453 dimerization interface 3.5A [polypeptide binding]; other site 985002006454 active site 985002006455 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 985002006456 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 985002006457 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 985002006458 Walker A/P-loop; other site 985002006459 ATP binding site [chemical binding]; other site 985002006460 Q-loop/lid; other site 985002006461 ABC transporter signature motif; other site 985002006462 Walker B; other site 985002006463 D-loop; other site 985002006464 H-loop/switch region; other site 985002006465 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 985002006466 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 985002006467 Walker A/P-loop; other site 985002006468 ATP binding site [chemical binding]; other site 985002006469 Q-loop/lid; other site 985002006470 ABC transporter signature motif; other site 985002006471 Walker B; other site 985002006472 D-loop; other site 985002006473 H-loop/switch region; other site 985002006474 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 985002006475 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 985002006476 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 985002006477 alphaNTD homodimer interface [polypeptide binding]; other site 985002006478 alphaNTD - beta interaction site [polypeptide binding]; other site 985002006479 alphaNTD - beta' interaction site [polypeptide binding]; other site 985002006480 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 985002006481 30S ribosomal protein S11; Validated; Region: PRK05309 985002006482 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 985002006483 30S ribosomal protein S13; Region: bact_S13; TIGR03631 985002006484 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 985002006485 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 985002006486 rRNA binding site [nucleotide binding]; other site 985002006487 predicted 30S ribosome binding site; other site 985002006488 adenylate kinase; Reviewed; Region: adk; PRK00279 985002006489 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 985002006490 AMP-binding site [chemical binding]; other site 985002006491 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 985002006492 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 985002006493 SecY translocase; Region: SecY; pfam00344 985002006494 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 985002006495 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 985002006496 23S rRNA binding site [nucleotide binding]; other site 985002006497 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 985002006498 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 985002006499 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 985002006500 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 985002006501 5S rRNA interface [nucleotide binding]; other site 985002006502 L27 interface [polypeptide binding]; other site 985002006503 23S rRNA interface [nucleotide binding]; other site 985002006504 L5 interface [polypeptide binding]; other site 985002006505 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 985002006506 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 985002006507 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 985002006508 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 985002006509 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 985002006510 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 985002006511 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 985002006512 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 985002006513 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 985002006514 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 985002006515 RNA binding site [nucleotide binding]; other site 985002006516 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 985002006517 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 985002006518 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 985002006519 23S rRNA interface [nucleotide binding]; other site 985002006520 putative translocon interaction site; other site 985002006521 signal recognition particle (SRP54) interaction site; other site 985002006522 L23 interface [polypeptide binding]; other site 985002006523 trigger factor interaction site; other site 985002006524 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 985002006525 23S rRNA interface [nucleotide binding]; other site 985002006526 5S rRNA interface [nucleotide binding]; other site 985002006527 putative antibiotic binding site [chemical binding]; other site 985002006528 L25 interface [polypeptide binding]; other site 985002006529 L27 interface [polypeptide binding]; other site 985002006530 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 985002006531 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 985002006532 G-X-X-G motif; other site 985002006533 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 985002006534 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 985002006535 putative translocon binding site; other site 985002006536 protein-rRNA interface [nucleotide binding]; other site 985002006537 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 985002006538 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 985002006539 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 985002006540 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 985002006541 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 985002006542 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 985002006543 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 985002006544 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 985002006545 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 985002006546 DNA topoisomerase III; Provisional; Region: PRK07726 985002006547 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 985002006548 active site 985002006549 putative interdomain interaction site [polypeptide binding]; other site 985002006550 putative metal-binding site [ion binding]; other site 985002006551 putative nucleotide binding site [chemical binding]; other site 985002006552 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 985002006553 domain I; other site 985002006554 DNA binding groove [nucleotide binding] 985002006555 phosphate binding site [ion binding]; other site 985002006556 domain II; other site 985002006557 domain III; other site 985002006558 nucleotide binding site [chemical binding]; other site 985002006559 catalytic site [active] 985002006560 domain IV; other site 985002006561 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 985002006562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002006563 Coenzyme A binding pocket [chemical binding]; other site 985002006564 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 985002006565 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 985002006566 Predicted permeases [General function prediction only]; Region: COG0679 985002006567 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 985002006568 Protein export membrane protein; Region: SecD_SecF; cl14618 985002006569 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 985002006570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 985002006571 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 985002006572 MarR family; Region: MarR_2; cl17246 985002006573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002006574 Major Facilitator Superfamily; Region: MFS_1; pfam07690 985002006575 putative substrate translocation pore; other site 985002006576 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 985002006577 Transcriptional regulators [Transcription]; Region: MarR; COG1846 985002006578 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 985002006579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 985002006580 FeS/SAM binding site; other site 985002006581 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 985002006582 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 985002006583 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 985002006584 GTP binding site; other site 985002006585 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 985002006586 MoaE interaction surface [polypeptide binding]; other site 985002006587 MoeB interaction surface [polypeptide binding]; other site 985002006588 thiocarboxylated glycine; other site 985002006589 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 985002006590 MoaE homodimer interface [polypeptide binding]; other site 985002006591 MoaD interaction [polypeptide binding]; other site 985002006592 active site residues [active] 985002006593 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 985002006594 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 985002006595 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 985002006596 dimer interface [polypeptide binding]; other site 985002006597 putative functional site; other site 985002006598 putative MPT binding site; other site 985002006599 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 985002006600 trimer interface [polypeptide binding]; other site 985002006601 dimer interface [polypeptide binding]; other site 985002006602 putative active site [active] 985002006603 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 985002006604 MPT binding site; other site 985002006605 trimer interface [polypeptide binding]; other site 985002006606 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 985002006607 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 985002006608 ATP binding site [chemical binding]; other site 985002006609 substrate interface [chemical binding]; other site 985002006610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 985002006611 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 985002006612 Walker A/P-loop; other site 985002006613 ATP binding site [chemical binding]; other site 985002006614 Q-loop/lid; other site 985002006615 ABC transporter signature motif; other site 985002006616 Walker B; other site 985002006617 D-loop; other site 985002006618 H-loop/switch region; other site 985002006619 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 985002006620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002006621 dimer interface [polypeptide binding]; other site 985002006622 conserved gate region; other site 985002006623 putative PBP binding loops; other site 985002006624 ABC-ATPase subunit interface; other site 985002006625 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 985002006626 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 985002006627 substrate binding pocket [chemical binding]; other site 985002006628 membrane-bound complex binding site; other site 985002006629 hinge residues; other site 985002006630 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 985002006631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002006632 Coenzyme A binding pocket [chemical binding]; other site 985002006633 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 985002006634 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 985002006635 active site 985002006636 dimerization interface [polypeptide binding]; other site 985002006637 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 985002006638 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 985002006639 intersubunit interface [polypeptide binding]; other site 985002006640 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 985002006641 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 985002006642 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 985002006643 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 985002006644 alpha-gamma subunit interface [polypeptide binding]; other site 985002006645 beta-gamma subunit interface [polypeptide binding]; other site 985002006646 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 985002006647 gamma-beta subunit interface [polypeptide binding]; other site 985002006648 alpha-beta subunit interface [polypeptide binding]; other site 985002006649 urease subunit alpha; Reviewed; Region: ureC; PRK13207 985002006650 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 985002006651 subunit interactions [polypeptide binding]; other site 985002006652 active site 985002006653 flap region; other site 985002006654 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 985002006655 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 985002006656 dimer interface [polypeptide binding]; other site 985002006657 catalytic residues [active] 985002006658 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 985002006659 UreF; Region: UreF; pfam01730 985002006660 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 985002006661 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 985002006662 MarR family; Region: MarR_2; cl17246 985002006663 MarR family; Region: MarR_2; cl17246 985002006664 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 985002006665 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 985002006666 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 985002006667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 985002006668 Surface antigen [General function prediction only]; Region: COG3942 985002006669 CHAP domain; Region: CHAP; pfam05257 985002006670 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 985002006671 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 985002006672 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 985002006673 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 985002006674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 985002006675 Surface antigen [General function prediction only]; Region: COG3942 985002006676 CHAP domain; Region: CHAP; pfam05257 985002006677 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 985002006678 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 985002006679 putative ligand binding site [chemical binding]; other site 985002006680 putative NAD binding site [chemical binding]; other site 985002006681 catalytic site [active] 985002006682 hypothetical protein; Provisional; Region: PRK06753 985002006683 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 985002006684 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 985002006685 Lysozyme subfamily 2; Region: LYZ2; smart00047 985002006686 Uncharacterized conserved protein [Function unknown]; Region: COG2427 985002006687 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 985002006688 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 985002006689 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 985002006690 4Fe-4S binding domain; Region: Fer4; pfam00037 985002006691 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 985002006692 [4Fe-4S] binding site [ion binding]; other site 985002006693 molybdopterin cofactor binding site; other site 985002006694 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 985002006695 molybdopterin cofactor binding site; other site 985002006696 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 985002006697 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 985002006698 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 985002006699 active site 985002006700 Predicted transcriptional regulator [Transcription]; Region: COG2378 985002006701 HTH domain; Region: HTH_11; pfam08279 985002006702 CAAX protease self-immunity; Region: Abi; pfam02517 985002006703 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 985002006704 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 985002006705 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 985002006706 putative active site [active] 985002006707 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 985002006708 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 985002006709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002006710 active site 985002006711 motif I; other site 985002006712 motif II; other site 985002006713 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 985002006714 Sodium Bile acid symporter family; Region: SBF; pfam01758 985002006715 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 985002006716 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 985002006717 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 985002006718 active site turn [active] 985002006719 phosphorylation site [posttranslational modification] 985002006720 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 985002006721 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 985002006722 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 985002006723 putative active site [active] 985002006724 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 985002006725 putative hydrophobic ligand binding site [chemical binding]; other site 985002006726 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 985002006727 oxidoreductase; Provisional; Region: PRK07985 985002006728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 985002006729 NAD(P) binding site [chemical binding]; other site 985002006730 active site 985002006731 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 985002006732 amidohydrolase; Region: amidohydrolases; TIGR01891 985002006733 metal binding site [ion binding]; metal-binding site 985002006734 dimer interface [polypeptide binding]; other site 985002006735 imidazolonepropionase; Validated; Region: PRK09356 985002006736 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 985002006737 active site 985002006738 urocanate hydratase; Provisional; Region: PRK05414 985002006739 Transcriptional regulator [Transcription]; Region: LysR; COG0583 985002006740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 985002006741 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 985002006742 dimerization interface [polypeptide binding]; other site 985002006743 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 985002006744 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 985002006745 active site 985002006746 metal binding site [ion binding]; metal-binding site 985002006747 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 985002006748 putative active site [active] 985002006749 putative metal binding site [ion binding]; other site 985002006750 CAAX protease self-immunity; Region: Abi; pfam02517 985002006751 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 985002006752 tetramer (dimer of dimers) interface [polypeptide binding]; other site 985002006753 active site 985002006754 dimer interface [polypeptide binding]; other site 985002006755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 985002006756 MOSC domain; Region: MOSC; pfam03473 985002006757 3-alpha domain; Region: 3-alpha; pfam03475 985002006758 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 985002006759 active site 985002006760 catalytic residues [active] 985002006761 Uncharacterized conserved protein [Function unknown]; Region: COG1742 985002006762 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 985002006763 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 985002006764 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 985002006765 Walker A/P-loop; other site 985002006766 ATP binding site [chemical binding]; other site 985002006767 Q-loop/lid; other site 985002006768 ABC transporter signature motif; other site 985002006769 Walker B; other site 985002006770 D-loop; other site 985002006771 H-loop/switch region; other site 985002006772 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 985002006773 Predicted membrane protein [Function unknown]; Region: COG3152 985002006774 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 985002006775 active site 985002006776 DNA binding site [nucleotide binding] 985002006777 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 985002006778 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 985002006779 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 985002006780 homotetramer interface [polypeptide binding]; other site 985002006781 FMN binding site [chemical binding]; other site 985002006782 homodimer contacts [polypeptide binding]; other site 985002006783 putative active site [active] 985002006784 putative substrate binding site [chemical binding]; other site 985002006785 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 985002006786 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 985002006787 oligomer interface [polypeptide binding]; other site 985002006788 metal binding site [ion binding]; metal-binding site 985002006789 metal binding site [ion binding]; metal-binding site 985002006790 putative Cl binding site [ion binding]; other site 985002006791 aspartate ring; other site 985002006792 basic sphincter; other site 985002006793 hydrophobic gate; other site 985002006794 periplasmic entrance; other site 985002006795 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 985002006796 active site 985002006797 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 985002006798 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 985002006799 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 985002006800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002006801 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 985002006802 putative substrate translocation pore; other site 985002006803 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 985002006804 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 985002006805 HlyD family secretion protein; Region: HlyD_3; pfam13437 985002006806 lipoyl-biotinyl attachment site [posttranslational modification]; other site 985002006807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 985002006808 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 985002006809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002006810 putative substrate translocation pore; other site 985002006811 Predicted membrane protein [Function unknown]; Region: COG4640 985002006812 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 985002006813 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 985002006814 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 985002006815 putative Zn2+ binding site [ion binding]; other site 985002006816 putative DNA binding site [nucleotide binding]; other site 985002006817 Uncharacterized conserved protein [Function unknown]; Region: COG1434 985002006818 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 985002006819 putative active site [active] 985002006820 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 985002006821 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 985002006822 Walker A/P-loop; other site 985002006823 ATP binding site [chemical binding]; other site 985002006824 Q-loop/lid; other site 985002006825 ABC transporter signature motif; other site 985002006826 Walker B; other site 985002006827 D-loop; other site 985002006828 H-loop/switch region; other site 985002006829 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 985002006830 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 985002006831 FtsX-like permease family; Region: FtsX; pfam02687 985002006832 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 985002006833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002006834 active site 985002006835 phosphorylation site [posttranslational modification] 985002006836 intermolecular recognition site; other site 985002006837 dimerization interface [polypeptide binding]; other site 985002006838 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 985002006839 DNA binding site [nucleotide binding] 985002006840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 985002006841 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 985002006842 dimerization interface [polypeptide binding]; other site 985002006843 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 985002006844 dimer interface [polypeptide binding]; other site 985002006845 phosphorylation site [posttranslational modification] 985002006846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002006847 ATP binding site [chemical binding]; other site 985002006848 Mg2+ binding site [ion binding]; other site 985002006849 G-X-G motif; other site 985002006850 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 985002006851 LytTr DNA-binding domain; Region: LytTR; smart00850 985002006852 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 985002006853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 985002006854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 985002006855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 985002006856 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 985002006857 Walker A/P-loop; other site 985002006858 ATP binding site [chemical binding]; other site 985002006859 Q-loop/lid; other site 985002006860 ABC transporter signature motif; other site 985002006861 Walker B; other site 985002006862 D-loop; other site 985002006863 H-loop/switch region; other site 985002006864 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 985002006865 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 985002006866 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 985002006867 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 985002006868 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 985002006869 L-lactate permease; Region: Lactate_perm; cl00701 985002006870 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 985002006871 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 985002006872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002006873 Coenzyme A binding pocket [chemical binding]; other site 985002006874 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 985002006875 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 985002006876 NAD(P) binding site [chemical binding]; other site 985002006877 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 985002006878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002006879 Coenzyme A binding pocket [chemical binding]; other site 985002006880 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 985002006881 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 985002006882 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 985002006883 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 985002006884 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 985002006885 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 985002006886 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 985002006887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 985002006888 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 985002006889 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 985002006890 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 985002006891 Cl binding site [ion binding]; other site 985002006892 oligomer interface [polypeptide binding]; other site 985002006893 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 985002006894 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 985002006895 active site turn [active] 985002006896 phosphorylation site [posttranslational modification] 985002006897 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 985002006898 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 985002006899 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 985002006900 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 985002006901 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 985002006902 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 985002006903 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 985002006904 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 985002006905 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 985002006906 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 985002006907 MarR family; Region: MarR_2; pfam12802 985002006908 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 985002006909 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 985002006910 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 985002006911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002006912 putative substrate translocation pore; other site 985002006913 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 985002006914 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 985002006915 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 985002006916 DNA binding residues [nucleotide binding] 985002006917 dimer interface [polypeptide binding]; other site 985002006918 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 985002006919 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 985002006920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002006921 active site 985002006922 phosphorylation site [posttranslational modification] 985002006923 intermolecular recognition site; other site 985002006924 dimerization interface [polypeptide binding]; other site 985002006925 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 985002006926 DNA binding residues [nucleotide binding] 985002006927 dimerization interface [polypeptide binding]; other site 985002006928 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 985002006929 Histidine kinase; Region: HisKA_3; pfam07730 985002006930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002006931 ATP binding site [chemical binding]; other site 985002006932 Mg2+ binding site [ion binding]; other site 985002006933 G-X-G motif; other site 985002006934 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 985002006935 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 985002006936 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 985002006937 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 985002006938 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 985002006939 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 985002006940 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 985002006941 [4Fe-4S] binding site [ion binding]; other site 985002006942 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 985002006943 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 985002006944 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 985002006945 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 985002006946 molybdopterin cofactor binding site; other site 985002006947 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 985002006948 active site 985002006949 SAM binding site [chemical binding]; other site 985002006950 homodimer interface [polypeptide binding]; other site 985002006951 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 985002006952 [2Fe-2S] cluster binding site [ion binding]; other site 985002006953 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 985002006954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 985002006955 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 985002006956 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 985002006957 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 985002006958 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 985002006959 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 985002006960 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 985002006961 putative active site [active] 985002006962 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 985002006963 active site 985002006964 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 985002006965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002006966 Coenzyme A binding pocket [chemical binding]; other site 985002006967 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 985002006968 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 985002006969 putative hydrophobic ligand binding site [chemical binding]; other site 985002006970 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 985002006971 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 985002006972 intersubunit interface [polypeptide binding]; other site 985002006973 YodA lipocalin-like domain; Region: YodA; pfam09223 985002006974 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 985002006975 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 985002006976 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 985002006977 Thioredoxin; Region: Thioredoxin_4; cl17273 985002006978 FemAB family; Region: FemAB; pfam02388 985002006979 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 985002006980 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 985002006981 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 985002006982 Walker A/P-loop; other site 985002006983 ATP binding site [chemical binding]; other site 985002006984 Q-loop/lid; other site 985002006985 ABC transporter signature motif; other site 985002006986 Walker B; other site 985002006987 D-loop; other site 985002006988 H-loop/switch region; other site 985002006989 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 985002006990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002006991 dimer interface [polypeptide binding]; other site 985002006992 conserved gate region; other site 985002006993 putative PBP binding loops; other site 985002006994 ABC-ATPase subunit interface; other site 985002006995 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 985002006996 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 985002006997 substrate binding pocket [chemical binding]; other site 985002006998 membrane-bound complex binding site; other site 985002006999 hinge residues; other site 985002007000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002007001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 985002007002 putative substrate translocation pore; other site 985002007003 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 985002007004 catalytic core [active] 985002007005 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 985002007006 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 985002007007 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 985002007008 B domain; Region: B; pfam02216 985002007009 B domain; Region: B; pfam02216 985002007010 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 985002007011 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 985002007012 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 985002007013 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 985002007014 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 985002007015 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 985002007016 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 985002007017 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 985002007018 catalytic residue [active] 985002007019 biotin synthase; Validated; Region: PRK06256 985002007020 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 985002007021 FeS/SAM binding site; other site 985002007022 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 985002007023 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 985002007024 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 985002007025 inhibitor-cofactor binding pocket; inhibition site 985002007026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002007027 catalytic residue [active] 985002007028 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 985002007029 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 985002007030 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 985002007031 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 985002007032 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 985002007033 Walker A/P-loop; other site 985002007034 ATP binding site [chemical binding]; other site 985002007035 Q-loop/lid; other site 985002007036 ABC transporter signature motif; other site 985002007037 Walker B; other site 985002007038 D-loop; other site 985002007039 H-loop/switch region; other site 985002007040 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 985002007041 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 985002007042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 985002007043 Walker A/P-loop; other site 985002007044 ATP binding site [chemical binding]; other site 985002007045 Q-loop/lid; other site 985002007046 ABC transporter signature motif; other site 985002007047 Walker B; other site 985002007048 D-loop; other site 985002007049 H-loop/switch region; other site 985002007050 Predicted membrane protein [Function unknown]; Region: COG2246 985002007051 GtrA-like protein; Region: GtrA; pfam04138 985002007052 glycerate kinase; Region: TIGR00045 985002007053 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 985002007054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002007055 putative substrate translocation pore; other site 985002007056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 985002007057 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 985002007058 putative phosphoesterase; Region: acc_ester; TIGR03729 985002007059 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 985002007060 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 985002007061 Spore germination protein; Region: Spore_permease; cl17796 985002007062 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 985002007063 Amino acid permease; Region: AA_permease_2; pfam13520 985002007064 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 985002007065 Beta-lactamase; Region: Beta-lactamase; pfam00144 985002007066 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 985002007067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 985002007068 NAD(P) binding site [chemical binding]; other site 985002007069 active site 985002007070 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 985002007071 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 985002007072 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 985002007073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002007074 putative substrate translocation pore; other site 985002007075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002007076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002007077 dimer interface [polypeptide binding]; other site 985002007078 conserved gate region; other site 985002007079 ABC-ATPase subunit interface; other site 985002007080 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 985002007081 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 985002007082 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 985002007083 dimer interface [polypeptide binding]; other site 985002007084 conserved gate region; other site 985002007085 putative PBP binding loops; other site 985002007086 ABC-ATPase subunit interface; other site 985002007087 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 985002007088 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 985002007089 Walker A/P-loop; other site 985002007090 ATP binding site [chemical binding]; other site 985002007091 Q-loop/lid; other site 985002007092 ABC transporter signature motif; other site 985002007093 Walker B; other site 985002007094 D-loop; other site 985002007095 H-loop/switch region; other site 985002007096 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 985002007097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 985002007098 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 985002007099 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 985002007100 amino acid transporter; Region: 2A0306; TIGR00909 985002007101 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 985002007102 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 985002007103 substrate binding pocket [chemical binding]; other site 985002007104 catalytic triad [active] 985002007105 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 985002007106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002007107 putative substrate translocation pore; other site 985002007108 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 985002007109 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 985002007110 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 985002007111 Walker A/P-loop; other site 985002007112 ATP binding site [chemical binding]; other site 985002007113 Q-loop/lid; other site 985002007114 ABC transporter signature motif; other site 985002007115 Walker B; other site 985002007116 D-loop; other site 985002007117 H-loop/switch region; other site 985002007118 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 985002007119 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 985002007120 oligomer interface [polypeptide binding]; other site 985002007121 active site 985002007122 metal binding site [ion binding]; metal-binding site 985002007123 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 985002007124 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 985002007125 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 985002007126 active site 985002007127 FMN binding site [chemical binding]; other site 985002007128 substrate binding site [chemical binding]; other site 985002007129 3Fe-4S cluster binding site [ion binding]; other site 985002007130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002007131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 985002007132 putative substrate translocation pore; other site 985002007133 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 985002007134 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 985002007135 Walker A/P-loop; other site 985002007136 ATP binding site [chemical binding]; other site 985002007137 Q-loop/lid; other site 985002007138 ABC transporter signature motif; other site 985002007139 Walker B; other site 985002007140 D-loop; other site 985002007141 H-loop/switch region; other site 985002007142 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 985002007143 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 985002007144 Walker A/P-loop; other site 985002007145 ATP binding site [chemical binding]; other site 985002007146 Q-loop/lid; other site 985002007147 ABC transporter signature motif; other site 985002007148 Walker B; other site 985002007149 D-loop; other site 985002007150 H-loop/switch region; other site 985002007151 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 985002007152 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 985002007153 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 985002007154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002007155 dimer interface [polypeptide binding]; other site 985002007156 conserved gate region; other site 985002007157 putative PBP binding loops; other site 985002007158 ABC-ATPase subunit interface; other site 985002007159 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 985002007160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 985002007161 dimer interface [polypeptide binding]; other site 985002007162 conserved gate region; other site 985002007163 putative PBP binding loops; other site 985002007164 ABC-ATPase subunit interface; other site 985002007165 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 985002007166 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 985002007167 substrate binding site [chemical binding]; other site 985002007168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 985002007169 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 985002007170 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 985002007171 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 985002007172 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 985002007173 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 985002007174 short chain dehydrogenase; Validated; Region: PRK08589 985002007175 classical (c) SDRs; Region: SDR_c; cd05233 985002007176 NAD(P) binding site [chemical binding]; other site 985002007177 active site 985002007178 AbgT putative transporter family; Region: ABG_transport; pfam03806 985002007179 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 985002007180 Uncharacterized conserved protein [Function unknown]; Region: COG2128 985002007181 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 985002007182 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 985002007183 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 985002007184 classical (c) SDRs; Region: SDR_c; cd05233 985002007185 NAD(P) binding site [chemical binding]; other site 985002007186 active site 985002007187 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 985002007188 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 985002007189 nucleophilic elbow; other site 985002007190 catalytic triad; other site 985002007191 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002007192 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002007193 Protein of unknown function, DUF576; Region: DUF576; pfam04507 985002007194 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 985002007195 PLD-like domain; Region: PLDc_2; pfam13091 985002007196 putative homodimer interface [polypeptide binding]; other site 985002007197 putative active site [active] 985002007198 catalytic site [active] 985002007199 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 985002007200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 985002007201 ATP binding site [chemical binding]; other site 985002007202 putative Mg++ binding site [ion binding]; other site 985002007203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 985002007204 nucleotide binding region [chemical binding]; other site 985002007205 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 985002007206 ATP-binding site [chemical binding]; other site 985002007207 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 985002007208 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 985002007209 active site 985002007210 8-oxo-dGMP binding site [chemical binding]; other site 985002007211 nudix motif; other site 985002007212 metal binding site [ion binding]; metal-binding site 985002007213 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 985002007214 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 985002007215 active site 985002007216 substrate binding site [chemical binding]; other site 985002007217 metal binding site [ion binding]; metal-binding site 985002007218 H+ Antiporter protein; Region: 2A0121; TIGR00900 985002007219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002007220 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 985002007221 G5 domain; Region: G5; pfam07501 985002007222 G5 domain; Region: G5; pfam07501 985002007223 G5 domain; Region: G5; pfam07501 985002007224 G5 domain; Region: G5; pfam07501 985002007225 G5 domain; Region: G5; pfam07501 985002007226 G5 domain; Region: G5; pfam07501 985002007227 G5 domain; Region: G5; pfam07501 985002007228 G5 domain; Region: G5; pfam07501 985002007229 G5 domain; Region: G5; pfam07501 985002007230 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 985002007231 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 985002007232 Transcriptional regulators [Transcription]; Region: MarR; COG1846 985002007233 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 985002007234 Transcriptional regulators [Transcription]; Region: MarR; COG1846 985002007235 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 985002007236 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 985002007237 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 985002007238 active site 985002007239 tetramer interface; other site 985002007240 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 985002007241 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 985002007242 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 985002007243 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 985002007244 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 985002007245 GntP family permease; Region: GntP_permease; pfam02447 985002007246 fructuronate transporter; Provisional; Region: PRK10034; cl15264 985002007247 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 985002007248 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 985002007249 N- and C-terminal domain interface [polypeptide binding]; other site 985002007250 active site 985002007251 catalytic site [active] 985002007252 metal binding site [ion binding]; metal-binding site 985002007253 carbohydrate binding site [chemical binding]; other site 985002007254 ATP binding site [chemical binding]; other site 985002007255 Transcriptional regulators [Transcription]; Region: GntR; COG1802 985002007256 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 985002007257 DNA-binding site [nucleotide binding]; DNA binding site 985002007258 FCD domain; Region: FCD; pfam07729 985002007259 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 985002007260 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 985002007261 DNA binding residues [nucleotide binding] 985002007262 dimer interface [polypeptide binding]; other site 985002007263 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 985002007264 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 985002007265 synthetase active site [active] 985002007266 NTP binding site [chemical binding]; other site 985002007267 metal binding site [ion binding]; metal-binding site 985002007268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 985002007269 Predicted membrane protein [Function unknown]; Region: COG1289 985002007270 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 985002007271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002007272 D-galactonate transporter; Region: 2A0114; TIGR00893 985002007273 putative substrate translocation pore; other site 985002007274 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 985002007275 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 985002007276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002007277 Major Facilitator Superfamily; Region: MFS_1; pfam07690 985002007278 putative substrate translocation pore; other site 985002007279 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 985002007280 MarR family; Region: MarR; pfam01047 985002007281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 985002007282 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 985002007283 Walker A/P-loop; other site 985002007284 ATP binding site [chemical binding]; other site 985002007285 Q-loop/lid; other site 985002007286 ABC transporter signature motif; other site 985002007287 Walker B; other site 985002007288 D-loop; other site 985002007289 H-loop/switch region; other site 985002007290 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 985002007291 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 985002007292 Uncharacterized membrane protein [Function unknown]; Region: COG3949 985002007293 Predicted esterase [General function prediction only]; Region: COG0400 985002007294 putative hydrolase; Provisional; Region: PRK11460 985002007295 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 985002007296 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 985002007297 Zn binding site [ion binding]; other site 985002007298 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 985002007299 Zn binding site [ion binding]; other site 985002007300 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 985002007301 MarR family; Region: MarR; pfam01047 985002007302 Predicted acetyltransferase [General function prediction only]; Region: COG2388 985002007303 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 985002007304 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 985002007305 putative metal binding site [ion binding]; other site 985002007306 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 985002007307 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 985002007308 dimer interface [polypeptide binding]; other site 985002007309 FMN binding site [chemical binding]; other site 985002007310 D-lactate dehydrogenase; Provisional; Region: PRK12480 985002007311 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 985002007312 homodimer interface [polypeptide binding]; other site 985002007313 ligand binding site [chemical binding]; other site 985002007314 NAD binding site [chemical binding]; other site 985002007315 catalytic site [active] 985002007316 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 985002007317 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 985002007318 active site 985002007319 motif I; other site 985002007320 motif II; other site 985002007321 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 985002007322 active site 985002007323 catalytic site [active] 985002007324 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 985002007325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002007326 Coenzyme A binding pocket [chemical binding]; other site 985002007327 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 985002007328 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 985002007329 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 985002007330 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 985002007331 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 985002007332 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 985002007333 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 985002007334 EamA-like transporter family; Region: EamA; pfam00892 985002007335 EamA-like transporter family; Region: EamA; pfam00892 985002007336 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 985002007337 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 985002007338 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 985002007339 catalytic residues [active] 985002007340 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 985002007341 active site 985002007342 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 985002007343 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 985002007344 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 985002007345 active site turn [active] 985002007346 phosphorylation site [posttranslational modification] 985002007347 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 985002007348 HPr interaction site; other site 985002007349 glycerol kinase (GK) interaction site [polypeptide binding]; other site 985002007350 active site 985002007351 phosphorylation site [posttranslational modification] 985002007352 pyruvate oxidase; Provisional; Region: PRK08611 985002007353 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 985002007354 PYR/PP interface [polypeptide binding]; other site 985002007355 tetramer interface [polypeptide binding]; other site 985002007356 dimer interface [polypeptide binding]; other site 985002007357 TPP binding site [chemical binding]; other site 985002007358 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 985002007359 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 985002007360 TPP-binding site [chemical binding]; other site 985002007361 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 985002007362 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 985002007363 Transcriptional regulator [Transcription]; Region: LysR; COG0583 985002007364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 985002007365 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 985002007366 putative dimerization interface [polypeptide binding]; other site 985002007367 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 985002007368 Surface antigen [General function prediction only]; Region: COG3942 985002007369 CHAP domain; Region: CHAP; pfam05257 985002007370 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 985002007371 homodimer interface [polypeptide binding]; other site 985002007372 catalytic residues [active] 985002007373 NAD binding site [chemical binding]; other site 985002007374 substrate binding pocket [chemical binding]; other site 985002007375 flexible flap; other site 985002007376 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 985002007377 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 985002007378 dimer interface [polypeptide binding]; other site 985002007379 active site 985002007380 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 985002007381 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 985002007382 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 985002007383 DNA binding site [nucleotide binding] 985002007384 active site 985002007385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002007386 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 985002007387 Walker A motif; other site 985002007388 ATP binding site [chemical binding]; other site 985002007389 Walker B motif; other site 985002007390 arginine finger; other site 985002007391 UvrB/uvrC motif; Region: UVR; pfam02151 985002007392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 985002007393 Walker A motif; other site 985002007394 ATP binding site [chemical binding]; other site 985002007395 Walker B motif; other site 985002007396 arginine finger; other site 985002007397 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 985002007398 Virus attachment protein p12 family; Region: P12; pfam12669 985002007399 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 985002007400 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 985002007401 G1 box; other site 985002007402 GTP/Mg2+ binding site [chemical binding]; other site 985002007403 Switch I region; other site 985002007404 G2 box; other site 985002007405 G3 box; other site 985002007406 Switch II region; other site 985002007407 G4 box; other site 985002007408 G5 box; other site 985002007409 Nucleoside recognition; Region: Gate; pfam07670 985002007410 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 985002007411 Nucleoside recognition; Region: Gate; pfam07670 985002007412 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 985002007413 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 985002007414 Protein export membrane protein; Region: SecD_SecF; cl14618 985002007415 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 985002007416 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 985002007417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 985002007418 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 985002007419 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 985002007420 Glutamate binding site [chemical binding]; other site 985002007421 homodimer interface [polypeptide binding]; other site 985002007422 NAD binding site [chemical binding]; other site 985002007423 catalytic residues [active] 985002007424 maltose O-acetyltransferase; Provisional; Region: PRK10092 985002007425 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 985002007426 active site 985002007427 substrate binding site [chemical binding]; other site 985002007428 trimer interface [polypeptide binding]; other site 985002007429 CoA binding site [chemical binding]; other site 985002007430 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 985002007431 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 985002007432 metal-binding site [ion binding] 985002007433 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 985002007434 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 985002007435 metal-binding site [ion binding] 985002007436 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 985002007437 Soluble P-type ATPase [General function prediction only]; Region: COG4087 985002007438 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 985002007439 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 985002007440 metal-binding site [ion binding] 985002007441 D-lactate dehydrogenase; Validated; Region: PRK08605 985002007442 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 985002007443 homodimer interface [polypeptide binding]; other site 985002007444 ligand binding site [chemical binding]; other site 985002007445 NAD binding site [chemical binding]; other site 985002007446 catalytic site [active] 985002007447 transaminase; Reviewed; Region: PRK08068 985002007448 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 985002007449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002007450 homodimer interface [polypeptide binding]; other site 985002007451 catalytic residue [active] 985002007452 Surface antigen [General function prediction only]; Region: COG3942 985002007453 CHAP domain; Region: CHAP; pfam05257 985002007454 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 985002007455 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 985002007456 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 985002007457 catalytic triad [active] 985002007458 catalytic triad [active] 985002007459 oxyanion hole [active] 985002007460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002007461 Coenzyme A binding pocket [chemical binding]; other site 985002007462 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 985002007463 N-acetyl-D-glucosamine binding site [chemical binding]; other site 985002007464 catalytic residue [active] 985002007465 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 985002007466 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 985002007467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 985002007468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 985002007469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 985002007470 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 985002007471 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 985002007472 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 985002007473 NmrA-like family; Region: NmrA; pfam05368 985002007474 NADP binding site [chemical binding]; other site 985002007475 active site 985002007476 regulatory binding site [polypeptide binding]; other site 985002007477 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 985002007478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 985002007479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 985002007480 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 985002007481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 985002007482 NAD(P) binding site [chemical binding]; other site 985002007483 active site 985002007484 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 985002007485 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 985002007486 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 985002007487 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 985002007488 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 985002007489 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 985002007490 Nucleoside recognition; Region: Gate; pfam07670 985002007491 Nucleoside recognition; Region: Gate; pfam07670 985002007492 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 985002007493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 985002007494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 985002007495 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 985002007496 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 985002007497 Phosphotransferase enzyme family; Region: APH; pfam01636 985002007498 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 985002007499 active site 985002007500 ATP binding site [chemical binding]; other site 985002007501 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 985002007502 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 985002007503 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 985002007504 quinone interaction residues [chemical binding]; other site 985002007505 active site 985002007506 catalytic residues [active] 985002007507 FMN binding site [chemical binding]; other site 985002007508 substrate binding site [chemical binding]; other site 985002007509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 985002007510 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 985002007511 FAD binding domain; Region: FAD_binding_3; pfam01494 985002007512 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 985002007513 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 985002007514 dimer interface [polypeptide binding]; other site 985002007515 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 985002007516 Predicted acyl esterases [General function prediction only]; Region: COG2936 985002007517 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 985002007518 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 985002007519 tetramerization interface [polypeptide binding]; other site 985002007520 active site 985002007521 pantoate--beta-alanine ligase; Region: panC; TIGR00018 985002007522 Pantoate-beta-alanine ligase; Region: PanC; cd00560 985002007523 active site 985002007524 ATP-binding site [chemical binding]; other site 985002007525 pantoate-binding site; other site 985002007526 HXXH motif; other site 985002007527 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 985002007528 oligomerization interface [polypeptide binding]; other site 985002007529 active site 985002007530 metal binding site [ion binding]; metal-binding site 985002007531 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 985002007532 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 985002007533 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 985002007534 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 985002007535 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 985002007536 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 985002007537 tetramer (dimer of dimers) interface [polypeptide binding]; other site 985002007538 NAD binding site [chemical binding]; other site 985002007539 dimer interface [polypeptide binding]; other site 985002007540 substrate binding site [chemical binding]; other site 985002007541 amino acid transporter; Region: 2A0306; TIGR00909 985002007542 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 985002007543 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 985002007544 inhibitor-cofactor binding pocket; inhibition site 985002007545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002007546 catalytic residue [active] 985002007547 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 985002007548 catalytic residue [active] 985002007549 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 985002007550 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 985002007551 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 985002007552 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 985002007553 acyl-activating enzyme (AAE) consensus motif; other site 985002007554 AMP binding site [chemical binding]; other site 985002007555 active site 985002007556 CoA binding site [chemical binding]; other site 985002007557 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 985002007558 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 985002007559 choline dehydrogenase; Validated; Region: PRK02106 985002007560 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 985002007561 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 985002007562 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 985002007563 tetramerization interface [polypeptide binding]; other site 985002007564 NAD(P) binding site [chemical binding]; other site 985002007565 catalytic residues [active] 985002007566 Predicted transcriptional regulators [Transcription]; Region: COG1510 985002007567 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 985002007568 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 985002007569 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 985002007570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 985002007571 FeS/SAM binding site; other site 985002007572 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 985002007573 Class III ribonucleotide reductase; Region: RNR_III; cd01675 985002007574 effector binding site; other site 985002007575 active site 985002007576 Zn binding site [ion binding]; other site 985002007577 glycine loop; other site 985002007578 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 985002007579 Citrate transporter; Region: CitMHS; pfam03600 985002007580 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 985002007581 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 985002007582 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 985002007583 Flavodoxin; Region: Flavodoxin_1; pfam00258 985002007584 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 985002007585 FAD binding pocket [chemical binding]; other site 985002007586 FAD binding motif [chemical binding]; other site 985002007587 catalytic residues [active] 985002007588 NAD binding pocket [chemical binding]; other site 985002007589 phosphate binding motif [ion binding]; other site 985002007590 beta-alpha-beta structure motif; other site 985002007591 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 985002007592 catalytic residues [active] 985002007593 dimer interface [polypeptide binding]; other site 985002007594 FtsX-like permease family; Region: FtsX; pfam02687 985002007595 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 985002007596 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 985002007597 Walker A/P-loop; other site 985002007598 ATP binding site [chemical binding]; other site 985002007599 Q-loop/lid; other site 985002007600 ABC transporter signature motif; other site 985002007601 Walker B; other site 985002007602 D-loop; other site 985002007603 H-loop/switch region; other site 985002007604 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 985002007605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 985002007606 ATP binding site [chemical binding]; other site 985002007607 Mg2+ binding site [ion binding]; other site 985002007608 G-X-G motif; other site 985002007609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 985002007610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 985002007611 active site 985002007612 phosphorylation site [posttranslational modification] 985002007613 intermolecular recognition site; other site 985002007614 dimerization interface [polypeptide binding]; other site 985002007615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 985002007616 DNA binding site [nucleotide binding] 985002007617 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 985002007618 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 985002007619 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 985002007620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 985002007621 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 985002007622 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 985002007623 NADH(P)-binding; Region: NAD_binding_10; pfam13460 985002007624 putative NAD(P) binding site [chemical binding]; other site 985002007625 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 985002007626 RibD C-terminal domain; Region: RibD_C; cl17279 985002007627 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 985002007628 classical (c) SDRs; Region: SDR_c; cd05233 985002007629 NAD(P) binding site [chemical binding]; other site 985002007630 active site 985002007631 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 985002007632 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 985002007633 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 985002007634 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 985002007635 dimer interface [polypeptide binding]; other site 985002007636 active site 985002007637 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 985002007638 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 985002007639 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 985002007640 MarR family; Region: MarR_2; pfam12802 985002007641 Predicted esterase [General function prediction only]; Region: COG0627 985002007642 S-formylglutathione hydrolase; Region: PLN02442 985002007643 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 985002007644 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 985002007645 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 985002007646 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 985002007647 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 985002007648 ligand binding site [chemical binding]; other site 985002007649 flexible hinge region; other site 985002007650 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 985002007651 carbamate kinase; Reviewed; Region: PRK12686 985002007652 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 985002007653 putative substrate binding site [chemical binding]; other site 985002007654 nucleotide binding site [chemical binding]; other site 985002007655 nucleotide binding site [chemical binding]; other site 985002007656 homodimer interface [polypeptide binding]; other site 985002007657 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 985002007658 ornithine carbamoyltransferase; Validated; Region: PRK02102 985002007659 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 985002007660 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 985002007661 arginine deiminase; Provisional; Region: PRK01388 985002007662 Arginine repressor [Transcription]; Region: ArgR; COG1438 985002007663 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 985002007664 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 985002007665 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 985002007666 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 985002007667 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 985002007668 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 985002007669 active site 985002007670 Zn binding site [ion binding]; other site 985002007671 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 985002007672 HTH domain; Region: HTH_11; pfam08279 985002007673 PRD domain; Region: PRD; pfam00874 985002007674 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 985002007675 active site 985002007676 P-loop; other site 985002007677 phosphorylation site [posttranslational modification] 985002007678 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 985002007679 active site 985002007680 phosphorylation site [posttranslational modification] 985002007681 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 985002007682 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 985002007683 active site 985002007684 P-loop; other site 985002007685 phosphorylation site [posttranslational modification] 985002007686 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 985002007687 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 985002007688 active site 985002007689 phosphorylation site [posttranslational modification] 985002007690 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 985002007691 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 985002007692 Predicted membrane protein [Function unknown]; Region: COG1511 985002007693 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 985002007694 Predicted membrane protein [Function unknown]; Region: COG1511 985002007695 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 985002007696 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 985002007697 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 985002007698 CHAP domain; Region: CHAP; pfam05257 985002007699 Isochorismatase family; Region: Isochorismatase; pfam00857 985002007700 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 985002007701 catalytic triad [active] 985002007702 conserved cis-peptide bond; other site 985002007703 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 985002007704 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 985002007705 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 985002007706 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 985002007707 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 985002007708 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 985002007709 ATP binding site [chemical binding]; other site 985002007710 putative Mg++ binding site [ion binding]; other site 985002007711 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 985002007712 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 985002007713 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 985002007714 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 985002007715 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 985002007716 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 985002007717 SecY translocase; Region: SecY; pfam00344 985002007718 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 985002007719 legume lectins; Region: lectin_L-type; cd01951 985002007720 homotetramer interaction site [polypeptide binding]; other site 985002007721 carbohydrate binding site [chemical binding]; other site 985002007722 metal binding site [ion binding]; metal-binding site 985002007723 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 985002007724 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 985002007725 methionine sulfoxide reductase A; Provisional; Region: PRK05528 985002007726 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 985002007727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 985002007728 Coenzyme A binding pocket [chemical binding]; other site 985002007729 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 985002007730 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 985002007731 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 985002007732 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 985002007733 Chain length determinant protein; Region: Wzz; cl15801 985002007734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 985002007735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 985002007736 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 985002007737 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 985002007738 DXD motif; other site 985002007739 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 985002007740 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 985002007741 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 985002007742 Acyltransferase family; Region: Acyl_transf_3; pfam01757 985002007743 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 985002007744 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 985002007745 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 985002007746 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 985002007747 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 985002007748 metal binding site [ion binding]; metal-binding site 985002007749 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 985002007750 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 985002007751 substrate binding site [chemical binding]; other site 985002007752 glutamase interaction surface [polypeptide binding]; other site 985002007753 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 985002007754 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 985002007755 catalytic residues [active] 985002007756 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 985002007757 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 985002007758 putative active site [active] 985002007759 oxyanion strand; other site 985002007760 catalytic triad [active] 985002007761 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 985002007762 putative active site pocket [active] 985002007763 4-fold oligomerization interface [polypeptide binding]; other site 985002007764 metal binding residues [ion binding]; metal-binding site 985002007765 3-fold/trimer interface [polypeptide binding]; other site 985002007766 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 985002007767 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 985002007768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 985002007769 homodimer interface [polypeptide binding]; other site 985002007770 catalytic residue [active] 985002007771 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 985002007772 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 985002007773 NAD binding site [chemical binding]; other site 985002007774 dimerization interface [polypeptide binding]; other site 985002007775 product binding site; other site 985002007776 substrate binding site [chemical binding]; other site 985002007777 zinc binding site [ion binding]; other site 985002007778 catalytic residues [active] 985002007779 ATP phosphoribosyltransferase; Region: HisG; cl15266 985002007780 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 985002007781 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 985002007782 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 985002007783 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 985002007784 putative active site [active] 985002007785 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 985002007786 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 985002007787 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 985002007788 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 985002007789 Walker A/P-loop; other site 985002007790 ATP binding site [chemical binding]; other site 985002007791 Q-loop/lid; other site 985002007792 ABC transporter signature motif; other site 985002007793 Walker B; other site 985002007794 D-loop; other site 985002007795 H-loop/switch region; other site 985002007796 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 985002007797 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 985002007798 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 985002007799 Walker A/P-loop; other site 985002007800 ATP binding site [chemical binding]; other site 985002007801 Q-loop/lid; other site 985002007802 ABC transporter signature motif; other site 985002007803 Walker B; other site 985002007804 D-loop; other site 985002007805 H-loop/switch region; other site 985002007806 hypothetical protein; Provisional; Region: PRK13661 985002007807 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 985002007808 Uncharacterized conserved protein [Function unknown]; Region: COG1912 985002007809 Uncharacterized conserved protein [Function unknown]; Region: COG2353 985002007810 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 985002007811 Strictosidine synthase; Region: Str_synth; pfam03088 985002007812 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 985002007813 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 985002007814 active site residue [active] 985002007815 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 985002007816 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 985002007817 putative substrate binding pocket [chemical binding]; other site 985002007818 AC domain interface; other site 985002007819 catalytic triad [active] 985002007820 AB domain interface; other site 985002007821 interchain disulfide; other site 985002007822 hypothetical protein; Validated; Region: PRK07668 985002007823 Predicted transcriptional regulators [Transcription]; Region: COG1695 985002007824 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 985002007825 DinB superfamily; Region: DinB_2; pfam12867 985002007826 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 985002007827 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 985002007828 transmembrane helices; other site 985002007829 Predicted permeases [General function prediction only]; Region: RarD; COG2962 985002007830 hypothetical protein; Provisional; Region: PRK07758 985002007831 SnoaL-like domain; Region: SnoaL_2; pfam12680 985002007832 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 985002007833 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 985002007834 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 985002007835 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 985002007836 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 985002007837 Walker A/P-loop; other site 985002007838 ATP binding site [chemical binding]; other site 985002007839 Q-loop/lid; other site 985002007840 ABC transporter signature motif; other site 985002007841 Walker B; other site 985002007842 D-loop; other site 985002007843 H-loop/switch region; other site 985002007844 FtsX-like permease family; Region: FtsX; pfam02687 985002007845 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 985002007846 DNA-binding site [nucleotide binding]; DNA binding site 985002007847 RNA-binding motif; other site 985002007848 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 985002007849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 985002007850 non-specific DNA binding site [nucleotide binding]; other site 985002007851 salt bridge; other site 985002007852 sequence-specific DNA binding site [nucleotide binding]; other site 985002007853 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 985002007854 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 985002007855 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 985002007856 ParB-like nuclease domain; Region: ParBc; pfam02195 985002007857 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 985002007858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 985002007859 S-adenosylmethionine binding site [chemical binding]; other site 985002007860 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 985002007861 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 985002007862 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 985002007863 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 985002007864 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 985002007865 trmE is a tRNA modification GTPase; Region: trmE; cd04164 985002007866 G1 box; other site 985002007867 GTP/Mg2+ binding site [chemical binding]; other site 985002007868 Switch I region; other site 985002007869 G2 box; other site 985002007870 Switch II region; other site 985002007871 G3 box; other site 985002007872 G4 box; other site 985002007873 G5 box; other site 985002007874 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 985002007875 ribonuclease P; Reviewed; Region: rnpA; PRK00499 985002007876 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 985002007877 Probable gene remnant 985002007878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 985002007879 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 985002007880 Integrase core domain; Region: rve; pfam00665 985002007881 Probable gene remnant 985002007882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 985002007883 putative DNA binding site [nucleotide binding]; other site 985002007884 putative Zn2+ binding site [ion binding]; other site 985002007885 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 985002007886 Cadmium resistance transporter; Region: Cad; pfam03596 985002007887 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 985002007888 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 985002007889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 985002007890 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 985002007891 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 985002007892 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 985002007893 NAD binding site [chemical binding]; other site 985002007894 homotetramer interface [polypeptide binding]; other site 985002007895 homodimer interface [polypeptide binding]; other site 985002007896 substrate binding site [chemical binding]; other site 985002007897 active site 985002007898 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 985002007899 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 985002007900 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 985002007901 Major Facilitator Superfamily; Region: MFS_1; pfam07690 985002007902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 985002007903 putative substrate translocation pore; other site 985002007904 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 985002007905 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 985002007906 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 985002007907 multiple promoter invertase; Provisional; Region: mpi; PRK13413 985002007908 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 985002007909 catalytic residues [active] 985002007910 catalytic nucleophile [active] 985002007911 Presynaptic Site I dimer interface [polypeptide binding]; other site 985002007912 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 985002007913 Synaptic Flat tetramer interface [polypeptide binding]; other site 985002007914 Synaptic Site I dimer interface [polypeptide binding]; other site 985002007915 DNA binding site [nucleotide binding] 985002007916 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 985002007917 DNA-binding interface [nucleotide binding]; DNA binding site 985002007918 multiple promoter invertase; Provisional; Region: mpi; PRK13413 985002007919 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 985002007920 catalytic residues [active] 985002007921 catalytic nucleophile [active] 985002007922 Presynaptic Site I dimer interface [polypeptide binding]; other site 985002007923 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 985002007924 Synaptic Flat tetramer interface [polypeptide binding]; other site 985002007925 Synaptic Site I dimer interface [polypeptide binding]; other site 985002007926 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 985002007927 DNA-binding interface [nucleotide binding]; DNA binding site 985002007928 Predicted transcriptional regulator [Transcription]; Region: COG3682 985002007929 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 985002007930 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 985002007931 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 985002007932 beta-lactamase TEM; Provisional; Region: PRK15442 985002007933 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 985002007934 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 985002007935 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 985002007936 putative active site [active] 985002007937 putative NTP binding site [chemical binding]; other site 985002007938 putative nucleic acid binding site [nucleotide binding]; other site