-- dump date 20140620_074327 -- class Genbank::misc_feature -- table misc_feature_note -- id note 282459000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 282459000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 282459000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459000004 Walker A motif; other site 282459000005 ATP binding site [chemical binding]; other site 282459000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 282459000007 Walker B motif; other site 282459000008 arginine finger; other site 282459000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 282459000010 DnaA box-binding interface [nucleotide binding]; other site 282459000011 Pfam match to entry PF00308 bac_dnaA, Bacterial dnaA protein, score 681.8, E-value 3.5e-202 282459000012 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000013 PS01008 DnaA protein signature. 282459000014 DNA polymerase III subunit beta; Validated; Region: PRK05643 282459000015 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 282459000016 putative DNA binding surface [nucleotide binding]; other site 282459000017 dimer interface [polypeptide binding]; other site 282459000018 beta-clamp/clamp loader binding surface; other site 282459000019 beta-clamp/translesion DNA polymerase binding surface; other site 282459000020 Pfam match to entry PF00712 DNA_pol3_beta, DNA polymerase III beta subunit, N-terminal domain, score 224.5, E-value 1.6e-64 282459000021 Pfam match to entry PF02767 DNA_pol3_beta_2, DNA polymerase III beta subunit, central domain, score 222.4, E-value 7e-64 282459000022 Pfam match to entry PF02768 DNA_pol3_beta_3, DNA polymerase III beta subunit, C-terminal domain, score 209.8, E-value 4.4e-60 282459000023 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 282459000024 recF protein; Region: recf; TIGR00611 282459000025 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 282459000026 Walker A/P-loop; other site 282459000027 ATP binding site [chemical binding]; other site 282459000028 Q-loop/lid; other site 282459000029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282459000030 ABC transporter signature motif; other site 282459000031 Walker B; other site 282459000032 D-loop; other site 282459000033 H-loop/switch region; other site 282459000034 Pfam match to entry PF02463 SMC_N, RecF/RecN/SMC N terminal domain, score -21.4, E-value 2.5e-05 282459000035 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000036 PS00617 RecF protein signature 1. 282459000037 PS00618 RecF protein signature 2. 282459000038 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 282459000039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459000040 Mg2+ binding site [ion binding]; other site 282459000041 G-X-G motif; other site 282459000042 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 282459000043 anchoring element; other site 282459000044 dimer interface [polypeptide binding]; other site 282459000045 ATP binding site [chemical binding]; other site 282459000046 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 282459000047 active site 282459000048 putative metal-binding site [ion binding]; other site 282459000049 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 282459000050 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 103.9, E-value 3.4e-28 282459000051 PS00154 E1-E2 ATPases phosphorylation site. 282459000052 Pfam match to entry PF00204 DNA_gyraseB, DNA gyrase B, score 321.1, E-value 1.4e-93 282459000053 PS00177 DNA topoisomerase II signature. 282459000054 Pfam match to entry PF01751 Toprim, Toprim domain, score 41.7, E-value 1.8e-09 282459000055 Pfam match to entry PF00986 DNA_gyraseB_C, DNA gyrase B subunit, carboxyl terminus, score 151.9, E-value 1.1e-42 282459000056 DNA gyrase subunit A; Validated; Region: PRK05560 282459000057 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 282459000058 CAP-like domain; other site 282459000059 active site 282459000060 primary dimer interface [polypeptide binding]; other site 282459000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 282459000062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 282459000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 282459000064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 282459000065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 282459000066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 282459000067 Pfam match to entry PF00521 DNA_topoisoIV, DNA gyrase/topoisomerase IV, subunit A, score 1062.4, E-value 0 282459000068 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000069 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller, score 58.1, E-value 2e-14 282459000070 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller, score 61.3, E-value 2.2e-15 282459000071 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller, score 55.3, E-value 1.4e-13 282459000072 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller, score 57.1, E-value 4.1e-14 282459000073 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller, score 56.6, E-value 5.5e-14 282459000074 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller, score 61.4, E-value 2e-15 282459000075 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 282459000076 putative substrate binding site [chemical binding]; other site 282459000077 putative ATP binding site [chemical binding]; other site 282459000078 Pfam match to entry PF01256 carb_kinase, Carbohydrate kinase, score 235.4, E-value 8.2e-68 282459000079 PS01050 Uncharacterized protein family UPF0031 signature 2. 282459000080 PS01049 Uncharacterized protein family UPF0031 signature 1. 282459000081 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 282459000082 active sites [active] 282459000083 tetramer interface [polypeptide binding]; other site 282459000084 Pfam match to entry PF00221 PAL, Phenylalanine and histidine ammonia-lyase, score 734.3, E-value 5.5e-218 282459000085 PS00488 Phenylalanine and histidine ammonia-lyases signature. 282459000086 seryl-tRNA synthetase; Provisional; Region: PRK05431 282459000087 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 282459000088 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 282459000089 dimer interface [polypeptide binding]; other site 282459000090 active site 282459000091 motif 1; other site 282459000092 motif 2; other site 282459000093 motif 3; other site 282459000094 Pfam match to entry PF02403 Seryl_tRNA_N, Seryl-tRNA synthetase N-terminal domain, score 68.6, E-value 1.3e-17 282459000095 Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II core domain (G, H, P, S and T), score 202.6, E-value 6.3e-58 282459000096 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 282459000097 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 282459000098 7 probable transmembrane helices predicted for SAS0010 by TMHMM2.0 at aa 15-32, 37-59, 63-85, 134-156, 161-183, 190-208 and 212-229 282459000099 Pfam match to entry PF03591 AzlC, AzlC protein, score 282.8, E-value 4.7e-82 282459000100 Signal peptide predicted for SAS0011 by SignalP 2.0 HMM (Signal peptide probabilty 0.880) with cleavage site probability 0.549 between residues 34 and 35; signal peptide 282459000101 Predicted membrane protein [Function unknown]; Region: COG4392 282459000102 Pfam match to entry PF06063 DUF931, Domain of unknown function (DUF931), score 126.1, E-value 6.9e-35 282459000103 4 probable transmembrane helices predicted for SAS0011 by TMHMM2.0 at aa 7-29, 39-58, 70-87 and 91-108 282459000104 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 282459000105 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 282459000106 Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold, score 27.5, E-value 3.2e-05 282459000107 Predicted membrane protein [Function unknown]; Region: COG4241 282459000108 7 probable transmembrane helices predicted for SAS0013 by TMHMM2.0 at aa 39-61, 76-107, 120-142, 188-210, 223-245, 255-277 and 290-312 282459000109 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 282459000110 Signal peptide predicted for SAS0014 by SignalP 2.0 HMM (Signal peptide probabilty 0.958) with cleavage site probability 0.498 between residues 39 and 40; signal peptide 282459000111 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 282459000112 DHH family; Region: DHH; pfam01368 282459000113 DHHA1 domain; Region: DHHA1; pfam02272 282459000114 2 probable transmembrane helices predicted for SAS0014 by TMHMM2.0 at aa 9-31 and 35-54 282459000115 Pfam match to entry PF01368 DHH, DHH family, score 87.3, E-value 3.4e-23 282459000116 Pfam match to entry PF02272 DHHA1, DHHA1 domain, score 41.5, E-value 2.1e-09 282459000117 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 282459000118 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 282459000119 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 282459000120 Pfam match to entry PF01281 Ribosomal_L9_N, Ribosomal protein L9, N-terminal domain, score 87.6, E-value 2.6e-23 282459000121 PS00651 Ribosomal protein L9 signature. 282459000122 Pfam match to entry PF03948 Ribosomal_L9_C, Ribosomal protein L9, C-terminal domain, score 118.1, E-value 1.7e-32 282459000123 replicative DNA helicase; Region: DnaB; TIGR00665 282459000124 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 282459000125 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 282459000126 Walker A motif; other site 282459000127 ATP binding site [chemical binding]; other site 282459000128 Walker B motif; other site 282459000129 DNA binding loops [nucleotide binding] 282459000130 Pfam match to entry PF00772 DnaB, DnaB-like helicase N terminal domain, score 169.4, E-value 6.4e-48 282459000131 Pfam match to entry PF03796 DnaB_C, DnaB-like helicase C terminal domain, score 482.1, E-value 4.6e-142 282459000132 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000133 Predicted helix-turn-helix motif for SAS0016 with score 1117.000, SD 2.99 at aa 346-367, sequence RTLKALARELECPVIALSQLSR 282459000134 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 282459000135 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 282459000136 GDP-binding site [chemical binding]; other site 282459000137 ACT binding site; other site 282459000138 IMP binding site; other site 282459000139 Pfam match to entry PF00709 Adenylsucc_synt, Adenylosuccinate synthetase, score 839.5, E-value 1.2e-249 282459000140 PS01266 Adenylosuccinate synthetase GTP-binding site. 282459000141 PS00513 Adenylosuccinate synthetase active site. 282459000142 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282459000143 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282459000144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459000145 active site 282459000146 phosphorylation site [posttranslational modification] 282459000147 intermolecular recognition site; other site 282459000148 dimerization interface [polypeptide binding]; other site 282459000149 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282459000150 DNA binding site [nucleotide binding] 282459000151 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 131.7, E-value 1.4e-36 282459000152 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 88.5, E-value 1.4e-23 282459000153 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 282459000154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 282459000155 dimerization interface [polypeptide binding]; other site 282459000156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 282459000157 putative active site [active] 282459000158 heme pocket [chemical binding]; other site 282459000159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282459000160 dimer interface [polypeptide binding]; other site 282459000161 phosphorylation site [posttranslational modification] 282459000162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459000163 ATP binding site [chemical binding]; other site 282459000164 Mg2+ binding site [ion binding]; other site 282459000165 G-X-G motif; other site 282459000166 2 probable transmembrane helices predicted for SAS0019 by TMHMM2.0 at aa 15-37 and 183-205 282459000167 Pfam match to entry PF00672 HAMP, HAMP domain, score 82.1, E-value 1.2e-21 282459000168 Pfam match to entry PF00989 PAS, PAS domain, score 40.7, E-value 3.5e-09 282459000169 Pfam match to entry PF00512 HisKA, His Kinase A (phosphoacceptor) domain, score 91.0, E-value 2.4e-24 282459000170 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 153.1, E-value 5.2e-43 282459000171 Signal peptide predicted for SAS0020 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.846 between residues 36 and 37; signal peptide 282459000172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 282459000173 YycH protein; Region: YycH; pfam07435 282459000174 1 probable transmembrane helix predicted for SAS0020 by TMHMM2.0 at aa 7-29 282459000175 YycH protein; Region: YycI; cl02015 282459000176 Signal peptide predicted for SAS0021 by SignalP 2.0 HMM (Signal peptide probabilty 0.852) with cleavage site probability 0.828 between residues 31 and 32; signal peptide 282459000177 1 probable transmembrane helix predicted for SAS0021 by TMHMM2.0 at aa 9-26 282459000178 Signal peptide predicted for SAS0022 by SignalP 2.0 HMM (Signal peptide probabilty 0.600) with cleavage site probability 0.235 between residues 23 and 24; signal peptide 282459000179 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 282459000180 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 60.7, E-value 3.4e-15 282459000181 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 282459000182 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 282459000183 putative active site [active] 282459000184 putative metal binding site [ion binding]; other site 282459000185 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 282459000186 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 282459000187 1 probable transmembrane helix predicted for SAS0023 by TMHMM2.0 at aa 17-39 282459000188 Pfam match to entry PF00149 Metallophos, Calcineurin-like phosphoesterase, score 65.8, E-value 9.5e-17 282459000189 PS00786 5'-nucleotidase signature 2. 282459000190 Pfam match to entry PF02872 5_nucleotidaseC, 5'-nucleotidase, C-terminal domain, score 221.7, E-value 1.1e-63 282459000191 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 16.5, E-value 0.00036 282459000192 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282459000193 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 282459000194 Pfam match to entry PF02590 DUF163, Uncharacterized ACR, COG1576, score 332.0, E-value 7.1e-97 282459000195 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 282459000196 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 282459000197 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282459000198 ATP binding site [chemical binding]; other site 282459000199 putative Mg++ binding site [ion binding]; other site 282459000200 Pfam match to entry PF04313 HSDR_N, Type I restriction enzyme R protein N terminus (HSDR_N), score 52.3, E-value 1.1e-12 282459000201 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 282459000202 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 282459000203 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 282459000204 Pfam match to entry PF01420 Methylase_S, Type I restriction modification DNA specificity domain, score 43.0, E-value 7.1e-10 282459000205 Pfam match to entry PF01420 Methylase_S, Type I restriction modification DNA specificity domain, score 43.5, E-value 5.1e-10 282459000206 HsdM N-terminal domain; Region: HsdM_N; pfam12161 282459000207 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 282459000208 Methyltransferase domain; Region: Methyltransf_26; pfam13659 282459000209 Pfam match to entry PF02384 N6_Mtase, N-6 DNA Methylase, score 72.3, E-value 1.1e-18 282459000210 PS00092 N-6 Adenine-specific DNA methylases signature. 282459000211 Pfam match to entry PF02506 Methylase_M, Type I restriction modification system, M protein, score -54.9, E-value 1.5e-05 282459000212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4333 282459000213 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 282459000214 Pfam match to entry PF06124 DUF960, Staphylococcal protein of unknown function (DUF960), score 234.2, E-value 1.9e-67 282459000215 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 282459000216 Pfam match to entry PF06106 DUF950, Staphylococcus protein of unknown function (DUF950), score 292.6, E-value 5.2e-85 282459000217 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 282459000218 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 282459000219 catalytic residues [active] 282459000220 catalytic nucleophile [active] 282459000221 Recombinase; Region: Recombinase; pfam07508 282459000222 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 282459000223 Pfam match to entry PF00239 resolvase, Resolvase, N terminal domain, score 109.6, E-value 6.5e-30 282459000224 PS00397 Site-specific recombinases active site. 282459000225 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 282459000226 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 282459000227 catalytic residues [active] 282459000228 catalytic nucleophile [active] 282459000229 Recombinase; Region: Recombinase; pfam07508 282459000230 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 282459000231 Pfam match to entry PF00239 resolvase, Resolvase, N terminal domain, score 56.9, E-value 4.6e-14 282459000232 Domain of unknown function (DUF927); Region: DUF927; pfam06048 282459000233 Pfam match to entry PF06048 DUF927, Domain of unknown function (DUF927), score 792.7, E-value 1.5e-235 282459000234 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000235 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 282459000236 FRG domain; Region: FRG; pfam08867 282459000237 Toll - interleukin 1 - resistance; Region: TIR; smart00255 282459000238 Pfam match to entry PF01582 TIR, TIR domain, score 42.5, E-value 1.2e-12 282459000239 Dehydratase family; Region: ILVD_EDD; cl00340 282459000240 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 282459000241 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 282459000242 dimer interface [polypeptide binding]; other site 282459000243 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 14.0, E-value 0.00074 282459000244 Predicted transcriptional regulator [Transcription]; Region: COG2378 282459000245 HTH domain; Region: HTH_11; pfam08279 282459000246 WYL domain; Region: WYL; pfam13280 282459000247 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 282459000248 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 282459000249 Ortholog of S. aureus MRSA252 (BX571856) SAR0082; Similar to the N-terminal regions of Streptococcus agalactiae transposase OrfB SWALL:Q93EY9 (EMBL:AF329275) (253 aa) fasta scores: E(): 1e-32, 48.62% id in 218 aa, and Streptococcus dysgalactiae transposase SWALL:Q9L442 (EMBL:AJ250837) (259 aa) fasta scores: E(): 1e-31, 47.7% id in 218 aa; transposase (fragment) 282459000250 Pfam match to entry PF00665 rve, Integrase core domain, score 34.9, E-value 2e-07 282459000251 Probable gene remnant. Similar to internal regions of Bacillus halodurans transposase SWALL:Q9JWP9 (EMBL:AP001518) (94 aa) fasta scores: E(): 6.6e-09, 63.88% id in 36 aa, and Staphylococcus aureus hypothetical protein SWALL:Q99WI5 (EMBL:AP003359) (98 aa) fasta scores: E(): 8.4e-09, 75% id in 36 aa;transposase (fragment) 282459000252 Predicted helix-turn-helix motif for SAS0050 with score 1445.000, SD 4.11 at aa 9-30, sequence KPRNEIIREYDLTPSALGKWIK 282459000253 Signal peptide predicted for SAS0051 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.905 between residues 24 and 25; signal peptide 282459000254 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 282459000255 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459000256 Pfam match to entry PF01123 Stap_Strp_toxin, Staphylococcal/Streptococcal toxin, OB-fold domain, score 129.8, E-value 5.3e-36 282459000257 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 94.0, E-value 3.2e-25 282459000258 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459000259 Similar to the N-terminal regions of Staphylococcus aureus enterotoxin type E precursor EntE SWALL:ETXE_STAAU (SWALL:P12993) (257 aa) fasta scores: E(): 1.7e-05, 44.06% id in 59 aa, and Staphylococcus aureus enterotoxin type D precursor EntD SWALL:ETXD_STAAU (SWALL:P20723) (258 aa) fasta scores: E(): 1.8e-05, 46.15% id in 65 aa;enterotoxin (fragment) 282459000260 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -16.1, E-value 0.023 282459000261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459000262 Coenzyme A binding pocket [chemical binding]; other site 282459000263 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 47.7, E-value 2.7e-11 282459000264 Signal peptide predicted for SAS0054 by SignalP 2.0 HMM (Signal peptide probabilty 0.967) with cleavage site probability 0.592 between residues 48 and 49; signal peptide 282459000265 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 282459000266 Pfam match to entry PF01925 DUF81, Domain of unknown function DUF81, score 145.3, E-value 1.1e-40 282459000267 7 probable transmembrane helices predicted for SAS0054 by TMHMM2.0 at aa 7-38, 81-103, 108-125, 140-171, 178-196, 201-223 and 236-250 282459000268 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 282459000269 putative homodimer interface [polypeptide binding]; other site 282459000270 putative homotetramer interface [polypeptide binding]; other site 282459000271 putative metal binding site [ion binding]; other site 282459000272 putative homodimer-homodimer interface [polypeptide binding]; other site 282459000273 putative allosteric switch controlling residues; other site 282459000274 Pfam match to entry PF02583 DUF156, Uncharacterised BCR, COG1937, score 66.5, E-value 5.9e-17 282459000275 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 282459000276 active site residue [active] 282459000277 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 282459000278 CPxP motif; other site 282459000279 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 282459000280 Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain, score 58.0, E-value 2.1e-14 282459000281 Pfam match to entry PF01206 UPF0033, Uncharacterized protein family UPF0033, score 25.4, E-value 8.3e-07 282459000282 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 282459000283 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 282459000284 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 282459000285 active site residue [active] 282459000286 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 77.5, E-value 2.8e-20 282459000287 Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain, score 42.7, E-value 8.6e-10 282459000288 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 282459000289 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 282459000290 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 282459000291 FMN binding site [chemical binding]; other site 282459000292 active site 282459000293 catalytic residues [active] 282459000294 substrate binding site [chemical binding]; other site 282459000295 Pfam match to entry PF01207 Dus, Dihydrouridine synthase (Dus), score 121.0, E-value 2.3e-33 282459000296 PS01136 Uncharacterized protein family UPF0034 signature. 282459000297 2 probable transmembrane helices predicted for SAS0060 by TMHMM2.0 at aa 10-32 and 37-59 282459000298 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 282459000299 Pfam match to entry PF04993 TfoX_N, TfoX N-terminal domain, score 118.6, E-value 1.3e-32 282459000300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459000301 H+ Antiporter protein; Region: 2A0121; TIGR00900 282459000302 putative substrate translocation pore; other site 282459000303 12 probable transmembrane helices predicted for SAS0062 by TMHMM2.0 at aa 12-34, 44-66, 75-97, 101-118, 139-161, 166-185, 219-241, 256-278, 285-304, 308-327, 340-359 and 374-393 282459000304 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 282459000305 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 282459000306 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 282459000307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 282459000308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 282459000309 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 282459000310 dimerization interface [polypeptide binding]; other site 282459000311 Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 65.3, E-value 1.4e-16 282459000312 Predicted helix-turn-helix motif for SAS0064 with score 1766.000, SD 5.20 at aa 16-37, sequence KNLTKASELLNYSQSTVSTHIE 282459000313 PS00044 Bacterial regulatory proteins, lysR family signature. 282459000314 Pfam match to entry PF03466 LysR_substrate, LysR substrate binding domain, score 21.4, E-value 3.3e-05 282459000315 Transcriptional regulator [Transcription]; Region: LysR; COG0583 282459000316 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 282459000317 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 282459000318 Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 62.3, E-value 1.1e-15 282459000319 PS00044 Bacterial regulatory proteins, lysR family signature. 282459000320 5 probable transmembrane helices predicted for SAS0067 by TMHMM2.0 at aa 4-26, 55-77, 87-109, 121-143 and 163-182 282459000321 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 282459000322 Part of AAA domain; Region: AAA_19; pfam13245 282459000323 AAA domain; Region: AAA_12; pfam13087 282459000324 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000325 4 probable transmembrane helices predicted for SAS0069 by TMHMM2.0 at aa 33-55, 59-81, 102-124 and 139-156 282459000326 Ortholog of S. aureus MRSA252 (BX571856) SAR0105; Highly similar to Staphylococcus aureus 1-phosphatidylinositol phosphodiesterase precursor plc SWALL:PLC_STAAU (SWALL:P45723) (311 aa) fasta scores: E(): 3.4e-113, 96.79% id in 312 aa. CDS contains a frameshift after codon 134;1-phosphatidylinositol phosphodiesterase precursor (pseudogene) 282459000327 Signal peptide predicted for SAS0070 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.972 between residues 26 and 27 282459000328 1 probable transmembrane helix predicted for SAS0070 by TMHMM2.0 at aa 7-24 282459000329 Pfam match to entry PF00388 PI-PLC-X, Phosphatidylinositol-specific phospholipase C, X domain, score 233.3, E-value 3.6e-67 282459000330 Signal peptide predicted for SAS0072 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.314 between residues 33 and 34; signal peptide 282459000331 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282459000332 Pfam match to entry PF04507 DUF576, Protein of unknown function, DUF576, score 605.9, E-value 2.4e-179 282459000333 1 probable transmembrane helix predicted for SAS0072 by TMHMM2.0 at aa 5-27 282459000334 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459000335 Signal peptide predicted for SAS0073 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.356 between residues 30 and 31; signal peptide 282459000336 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282459000337 Pfam match to entry PF04507 DUF576, Protein of unknown function, DUF576, score 569.3, E-value 2.5e-168 282459000338 1 probable transmembrane helix predicted for SAS0073 by TMHMM2.0 at aa 5-27 282459000339 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459000340 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282459000341 Signal peptide predicted for SAS0074 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.481 between residues 28 and 29; signal peptide 282459000342 Pfam match to entry PF04507 DUF576, Protein of unknown function, DUF576, score 599.5, E-value 2.2e-177 282459000343 1 probable transmembrane helix predicted for SAS0074 by TMHMM2.0 at aa 7-26 282459000344 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459000345 Esterase/lipase [General function prediction only]; Region: COG1647 282459000346 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 282459000347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 282459000348 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 282459000349 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 33.6, E-value 4.9e-07 282459000350 Predicted helix-turn-helix motif for SAS0078 with score 1807.000, SD 5.34 at aa 172-193, sequence LSLSELSEYVGWSESHLSKKFT 282459000351 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 37.2, E-value 4e-08 282459000352 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 282459000353 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 282459000354 metal binding site [ion binding]; metal-binding site 282459000355 dimer interface [polypeptide binding]; other site 282459000356 Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40, score 376.0, E-value 4e-110 282459000357 Signal peptide predicted for SAS0080 by SignalP 2.0 HMM (Signal peptide probabilty 0.950) with cleavage site probability 0.596 between residues 41 and 42; signal peptide 282459000358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459000359 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282459000360 putative substrate translocation pore; other site 282459000361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459000362 14 probable transmembrane helices predicted for SAS0080 by TMHMM2.0 at aa 7-26, 46-68, 80-102, 106-123, 136-158, 162-181, 201-223, 227-244, 265-285, 295-317, 330-349, 353-375, 403-425 and 430-452 282459000363 PS00079 Multicopper oxidases signature 1. 282459000364 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 282459000365 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 282459000366 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 282459000367 PhoU domain; Region: PhoU; pfam01895 282459000368 9 probable transmembrane helices predicted for SAS0081 by TMHMM2.0 at aa 5-27, 53-75, 88-107, 112-127, 134-156, 176-198, 210-232, 247-269 and 289-311 282459000369 Pfam match to entry PF02690 Na_Pi_cotrans, Na+/Pi-cotransporter, score 1.8, E-value 0.00013 282459000370 Pfam match to entry PF02690 Na_Pi_cotrans, Na+/Pi-cotransporter, score 263.1, E-value 4e-76 282459000371 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 282459000372 Pfam match to entry PF06100 Strep_67kDa_ant, Streptococcal 67 kDa myosin-cross-reactive antigen like family, score 1416.7, E-value 0 282459000373 Signal peptide predicted for SAS0083 by SignalP 2.0 HMM (Signal peptide probabilty 0.971) with cleavage site probability 0.606 between residues 27 and 28; signal peptide 282459000374 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 282459000375 4 probable transmembrane helices predicted for SAS0083 by TMHMM2.0 at aa 7-26, 51-73, 94-116 and 126-148 282459000376 Signal peptide predicted for SAS0084 by SignalP 2.0 HMM (Signal peptide probabilty 0.807) with cleavage site probability 0.671 between residues 40 and 41; signal peptide 282459000377 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 282459000378 L-lactate permease; Region: Lactate_perm; cl00701 282459000379 13 probable transmembrane helices predicted for SAS0084 by TMHMM2.0 at aa 12-34, 38-60, 67-89, 127-149, 156-178, 193-215, 224-246, 250-267, 293-315, 348-370, 391-413, 423-445 and 512-529 282459000380 Pfam match to entry PF02652 Lactate_perm, L-lactate permease, score 654.5, E-value 5.7e-194 282459000381 PS00904 Protein prenyltransferases alpha subunit repeat signature. 282459000382 Signal peptide predicted for SAS0085 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.783 between residues 36 and 37; signal peptide 282459000383 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282459000384 B domain; Region: B; pfam02216 282459000385 B domain; Region: B; pfam02216 282459000386 B domain; Region: B; pfam02216 282459000387 B domain; Region: B; pfam02216 282459000388 B domain; Region: B; pfam02216 282459000389 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282459000390 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 43.4, E-value 5.2e-10 282459000391 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282459000392 Pfam match to entry PF01476 LysM, LysM domain, score 59.6, E-value 7.2e-15 282459000393 Pfam match to entry PF03373 Octapeptide, Octapeptide repeat, score 7.9, E-value 1.1 282459000394 Pfam match to entry PF03373 Octapeptide, Octapeptide repeat, score 10.2, E-value 0.24 282459000395 Pfam match to entry PF03373 Octapeptide, Octapeptide repeat, score 9.0, E-value 0.51 282459000396 Pfam match to entry PF03373 Octapeptide, Octapeptide repeat, score 9.4, E-value 0.4 282459000397 Pfam match to entry PF03373 Octapeptide, Octapeptide repeat, score 9.0, E-value 0.51 282459000398 Pfam match to entry PF03373 Octapeptide, Octapeptide repeat, score 10.2, E-value 0.24 282459000399 Pfam match to entry PF03373 Octapeptide, Octapeptide repeat, score 9.0, E-value 0.51 282459000400 Pfam match to entry PF03373 Octapeptide, Octapeptide repeat, score 9.0, E-value 0.51 282459000401 Pfam match to entry PF03373 Octapeptide, Octapeptide repeat, score 8.7, E-value 0.62 282459000402 Pfam match to entry PF02216 B, B domain, score 120.3, E-value 3.8e-33 282459000403 Pfam match to entry PF02216 B, B domain, score 124.8, E-value 1.6e-34 282459000404 Pfam match to entry PF02216 B, B domain, score 124.1, E-value 2.7e-34 282459000405 Pfam match to entry PF02216 B, B domain, score 127.2, E-value 3.2e-35 282459000406 Pfam match to entry PF02216 B, B domain, score 124.1, E-value 2.7e-34 282459000407 1 probable transmembrane helix predicted for SAS0085 by TMHMM2.0 at aa 12-34 282459000408 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 42.9, E-value 7.7e-10 282459000409 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282459000410 Transcriptional regulators [Transcription]; Region: MarR; COG1846 282459000411 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282459000412 Transcriptional regulators [Transcription]; Region: MarR; COG1846 282459000413 Signal peptide predicted for SAS0087 by SignalP 2.0 HMM (Signal peptide probabilty 0.877) with cleavage site probability 0.411 between residues 32 and 33; signal peptide 282459000414 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 282459000415 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282459000416 ABC-ATPase subunit interface; other site 282459000417 dimer interface [polypeptide binding]; other site 282459000418 putative PBP binding regions; other site 282459000419 9 probable transmembrane helices predicted for SAS0087 by TMHMM2.0 at aa 13-35, 59-81, 94-111, 115-137, 149-171, 191-213, 244-266, 281-303 and 310-329 282459000420 Pfam match to entry PF01032 FecCD, FecCD transport family, score 271.5, E-value 1.1e-78 282459000421 Signal peptide predicted for SAS0088 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.500 between residues 31 and 32; signal peptide 282459000422 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 282459000423 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282459000424 ABC-ATPase subunit interface; other site 282459000425 dimer interface [polypeptide binding]; other site 282459000426 putative PBP binding regions; other site 282459000427 Pfam match to entry PF01032 FecCD, FecCD transport family, score 333.1, E-value 3.4e-97 282459000428 9 probable transmembrane helices predicted for SAS0088 by TMHMM2.0 at aa 9-31, 58-77, 90-112, 116-135, 148-170, 195-217, 241-263, 278-300 and 307-324 282459000429 Signal peptide predicted for SAS0089 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.641 between residues 27 and 28; signal peptide 282459000430 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 282459000431 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 282459000432 siderophore binding site; other site 282459000433 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 176.6, E-value 4.2e-50 282459000434 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459000435 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 282459000436 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 282459000437 dimer interface [polypeptide binding]; other site 282459000438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459000439 catalytic residue [active] 282459000440 Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme, score 271.1, E-value 1.5e-78 282459000441 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 282459000442 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 282459000443 Pfam match to entry PF02423 ODC_Mu_crystall, Ornithine cyclodeaminase/mu-crystallin family, score 178.5, E-value 1.1e-50 282459000444 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 282459000445 IucA / IucC family; Region: IucA_IucC; pfam04183 282459000446 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 282459000447 Pfam match to entry PF04183 IucA_IucC, IucA / IucC family, score 600.6, E-value 9.7e-178 282459000448 Signal peptide predicted for SAS0093 by SignalP 2.0 HMM (Signal peptide probabilty 0.803) with cleavage site probability 0.509 between residues 56 and 57; signal peptide 282459000449 drug efflux system protein MdtG; Provisional; Region: PRK09874 282459000450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459000451 putative substrate translocation pore; other site 282459000452 10 probable transmembrane helices predicted for SAS0093 by TMHMM2.0 at aa 13-35, 50-72, 85-107, 164-186, 222-244, 259-276, 288-307, 317-339, 346-368 and 378-397 282459000453 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -84.1, E-value 0.00035 282459000454 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 282459000455 IucA / IucC family; Region: IucA_IucC; pfam04183 282459000456 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 282459000457 Pfam match to entry PF04183 IucA_IucC, IucA / IucC family, score 601.7, E-value 4.6e-178 282459000458 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 282459000459 IucA / IucC family; Region: IucA_IucC; pfam04183 282459000460 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 282459000461 Pfam match to entry PF04183 IucA_IucC, IucA / IucC family, score 695.8, E-value 2.1e-206 282459000462 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 282459000463 Pfam match to entry PF03328 HpcH_HpaI, HpcH/HpaI aldolase family, score 106.6, E-value 4.9e-29 282459000464 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 282459000465 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 282459000466 dimer interface [polypeptide binding]; other site 282459000467 active site 282459000468 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 282459000469 catalytic residues [active] 282459000470 substrate binding site [chemical binding]; other site 282459000471 Pfam match to entry PF02784 Orn_Arg_deC_N, Pyridoxal-dependent decarboxylase, pyridoxal binding domain, score 88.0, E-value 2e-23 282459000472 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 282459000473 Pfam match to entry PF00278 Orn_DAP_Arg_deC, Pyridoxal-dependent decarboxylase, C-terminal sheet domain, score -7.2, E-value 6e-05 282459000474 PS00213 Lipocalin signature. 282459000475 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 282459000476 ParB-like nuclease domain; Region: ParBc; pfam02195 282459000477 Pfam match to entry PF02195 ParBc, ParB-like nuclease domain, score 33.9, E-value 2.6e-09 282459000478 3 probable transmembrane helices predicted for SAS0099 by TMHMM2.0 at aa 10-29, 41-63 and 73-95 282459000479 3 probable transmembrane helices predicted for SAS0100 by TMHMM2.0 at aa 20-42, 57-79 and 92-114 282459000480 acetoin reductase; Validated; Region: PRK08643 282459000481 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 282459000482 NAD binding site [chemical binding]; other site 282459000483 homotetramer interface [polypeptide binding]; other site 282459000484 homodimer interface [polypeptide binding]; other site 282459000485 active site 282459000486 substrate binding site [chemical binding]; other site 282459000487 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 282.8, E-value 4.7e-82 282459000488 PS00061 Short-chain dehydrogenases/reductases family signature. 282459000489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 282459000490 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 282459000491 NAD(P) binding site [chemical binding]; other site 282459000492 active site 282459000493 Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family, score 280.1, E-value 2.9e-81 282459000494 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 282459000495 Pfam match to entry PF02397 Bact_transf, Bacterial sugar transferase, score 154.9, E-value 1.5e-43 282459000496 1 probable transmembrane helix predicted for SAS0103 by TMHMM2.0 at aa 50-72 282459000497 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 282459000498 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 282459000499 putative ADP-binding pocket [chemical binding]; other site 282459000500 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 108.3, E-value 1.6e-29 282459000501 Signal peptide predicted for SAS0105 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.741 between residues 28 and 29; signal peptide 282459000502 12 probable transmembrane helices predicted for SAS0105 by TMHMM2.0 at aa 9-28, 32-54, 59-81, 91-113, 120-142, 166-188, 195-217, 232-254, 289-311, 331-353, 360-379 and 383-400 282459000503 Pfam match to entry PF04932 Wzy_C, O-Antigen Polymerase, score 54.2, E-value 2.9e-13 282459000504 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 282459000505 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 282459000506 Pfam match to entry PF01943 Polysacc_synt, Polysaccharide biosynthesis protein, score 115.8, E-value 8.6e-32 282459000507 13 probable transmembrane helices predicted for SAS0106 by TMHMM2.0 at aa 43-65, 86-108, 113-135, 142-161, 171-190, 221-243, 247-266, 292-314, 319-341, 354-376, 380-399, 408-430 and 434-456 282459000508 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 282459000509 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 282459000510 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 282459000511 Pfam match to entry PF00081 sodfe, Iron/manganese superoxide dismutases, alpha-hairpin domain, score 172.7, E-value 6.4e-49 282459000512 Pfam match to entry PF02777 sodfe_C, Iron/manganese superoxide dismutases, C-terminal domain, score 209.6, E-value 4.8e-60 282459000513 PS00088 Manganese and iron superoxide dismutases signature. 282459000514 Signal peptide predicted for SAS0108 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 28 and 29; signal peptide 282459000515 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 33.1, E-value 6.7e-07 282459000516 1 probable transmembrane helix predicted for SAS0108 by TMHMM2.0 at aa 212-234 282459000517 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 282459000518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 282459000519 DNA-binding site [nucleotide binding]; DNA binding site 282459000520 Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 67.7, E-value 2.6e-17 282459000521 PS00043 Bacterial regulatory proteins, gntR family signature. 282459000522 Predicted helix-turn-helix motif for SAS0109 with score 1559.000, SD 4.50 at aa 31-52, sequence PTEKELCARFDVSRMTLRQAIK 282459000523 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 282459000524 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 282459000525 Pfam match to entry PF01048 PNP_UDP_1, Phosphorylase family, score 293.2, E-value 3.3e-85 282459000526 PS01232 Purine and other phosphorylases family 1 signature. 282459000527 Signal peptide predicted for SAS0111 by SignalP 2.0 HMM (Signal peptide probabilty 0.973) with cleavage site probability 0.775 between residues 37 and 38; signal peptide 282459000528 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282459000529 14 probable transmembrane helices predicted for SAS0111 by TMHMM2.0 at aa 12-34, 47-69, 76-98, 102-124, 136-158, 163-185, 198-215, 220-237, 258-280, 290-309, 321-340, 344-366, 379-401 and 421-443 282459000530 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 282459000531 intersubunit interface [polypeptide binding]; other site 282459000532 active site 282459000533 catalytic residue [active] 282459000534 Pfam match to entry PF01791 DeoC, Deoxyribose-phosphate aldolase, score 348.3, E-value 9e-102 282459000535 phosphopentomutase; Provisional; Region: PRK05362 282459000536 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 282459000537 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000538 Pfam match to entry PF01676 Metalloenzyme, Metalloenzyme superfamily, score 129.4, E-value 6.9e-36 282459000539 Signal peptide predicted for SAS0114 by SignalP 2.0 HMM (Signal peptide probabilty 0.974) with cleavage site probability 0.282 between residues 45 and 46; signal peptide 282459000540 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 282459000541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459000542 dimer interface [polypeptide binding]; other site 282459000543 conserved gate region; other site 282459000544 putative PBP binding loops; other site 282459000545 ABC-ATPase subunit interface; other site 282459000546 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 38.3, E-value 1.9e-08 282459000547 6 probable transmembrane helices predicted for SAS0114 by TMHMM2.0 at aa 23-45, 83-105, 117-139, 191-208, 215-237 and 247-266 282459000548 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 282459000549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459000550 dimer interface [polypeptide binding]; other site 282459000551 conserved gate region; other site 282459000552 ABC-ATPase subunit interface; other site 282459000553 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 64.4, E-value 2.6e-16 282459000554 6 probable transmembrane helices predicted for SAS0115 by TMHMM2.0 at aa 21-43, 83-105, 118-140, 145-164, 185-207 and 232-254 282459000555 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 282459000556 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 282459000557 Walker A/P-loop; other site 282459000558 ATP binding site [chemical binding]; other site 282459000559 Q-loop/lid; other site 282459000560 ABC transporter signature motif; other site 282459000561 Walker B; other site 282459000562 D-loop; other site 282459000563 H-loop/switch region; other site 282459000564 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 180.7, E-value 2.5e-51 282459000565 PS00211 ABC transporters family signature. 282459000566 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000567 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 282459000568 Signal peptide predicted for SAS0117 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.259 between residues 22 and 23; signal peptide 282459000569 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 282459000570 1 probable transmembrane helix predicted for SAS0117 by TMHMM2.0 at aa 7-26 282459000571 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459000572 Signal peptide predicted for SAS0118 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.634 between residues 27 and 28; signal peptide 282459000573 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 282459000574 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 282459000575 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 282459000576 active site 282459000577 metal binding site [ion binding]; metal-binding site 282459000578 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 282459000579 Pfam match to entry PF00149 Metallophos, Calcineurin-like phosphoesterase, score 56.2, E-value 7.4e-14 282459000580 PS00786 5'-nucleotidase signature 2. 282459000581 Pfam match to entry PF02872 5_nucleotidaseC, 5'-nucleotidase, C-terminal domain, score 173.1, E-value 4.9e-49 282459000582 Possible gene remnant. Weakly similar to the C-terminal regions of Streptococcus pneumoniae conserved hypothetical protein spr1629 SWALL:Q8DNN0 (EMBL:AE008529) (383 aa) fasta scores: E(): 2.4, 26.02% id in 73 aa, and Streptococcus agalactiae hypothetical protein gbs1980 SWALL:Q8E2Y3 (EMBL:AL766855) (124 aa) fasta scores: E(): 9, 31.5% id in 73 aa;hypothetical protein (fragment) 282459000583 Similar to the C-terminal regions of Staphylococcus aureus replication initiation protein RepE SWALL:REPE_STAAU (SWALL:P12053) (314 aa) fasta scores: E(): 4.9e-81, 73.68% id in 266 aa, and to Staphylococcus aureus replication initiation protein RepN SWALL:REPN_STAAU (SWALL:P19529) (314 aa) fasta scores: E(): 2.3e-81, 74.43% id in 266 aa. Contains a frameshift after codon 158;replication initiation protein (fragment) 282459000584 Pfam match to entry PF02486 Rep_trans, Replication initiation factor, score -15.7, E-value 0.0025 282459000585 Pfam match to entry PF02486 Rep_trans, Replication initiation factor, score 19.8, E-value 2.6e-05 282459000586 Similar to Salmonella typhi transposase for insertion sequence element IS200 SWALL:T200_SALTI (SWALL:P59697) (152 aa) fasta scores: E(): 1e-34, 58.66% id in 150 aa, and to Clostridium acetobutylicum IS605/IS200-like transposase cac3531 SWALL:Q97DE6 (EMBL:AE007849) (157 aa) fasta scores: E(): 1.2e-48, 78.2% id in 156 aa. CDS contains a nonsense mutation (ochre) after codon 16 and a frameshift after codon 86;transposase (pseudogene) 282459000587 Pfam match to entry PF01797 Transposase_17, Transposase IS200 like, score 50.0, E-value 4.6e-14 282459000588 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 282459000589 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 282459000590 putative catalytic cysteine [active] 282459000591 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 282459000592 putative active site [active] 282459000593 metal binding site [ion binding]; metal-binding site 282459000594 Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family, score -176.9, E-value 7.2e-07 282459000595 Pfam match to entry PF00465 Fe-ADH, Iron-containing alcohol dehydrogenase, score 490.0, E-value 1.9e-144 282459000596 PS00913 Iron-containing alcohol dehydrogenases signature 1. 282459000597 PS00060 Iron-containing alcohol dehydrogenases signature 2. 282459000598 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 282459000599 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 282459000600 Pfam match to entry PF02706 wzz, Chain length determinant protein, score 157.5, E-value 2.4e-44 282459000601 2 probable transmembrane helices predicted for SAS0124 by TMHMM2.0 at aa 20-42 and 172-191 282459000602 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 282459000603 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 282459000604 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 282459000605 Pfam match to entry PF02811 PHP_C, PHP domain C-terminal region, score 47.3, E-value 3.5e-11 282459000606 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 282459000607 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 282459000608 NAD(P) binding site [chemical binding]; other site 282459000609 homodimer interface [polypeptide binding]; other site 282459000610 substrate binding site [chemical binding]; other site 282459000611 active site 282459000612 4 probable transmembrane helices predicted for SAS0127 by TMHMM2.0 at aa 10-32, 44-62, 77-99 and 104-126 282459000613 Pfam match to entry PF02719 Polysacc_synt_2, Polysaccharide biosynthesis protein, score 1244.4, E-value 0 282459000614 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 282459000615 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 282459000616 NAD(P) binding site [chemical binding]; other site 282459000617 homodimer interface [polypeptide binding]; other site 282459000618 substrate binding site [chemical binding]; other site 282459000619 active site 282459000620 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 282459000621 Pfam match to entry PF02719 Polysacc_synt_2, Polysaccharide biosynthesis protein, score -255.6, E-value 2.2e-09 282459000622 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 282459000623 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 282459000624 putative NAD(P) binding site [chemical binding]; other site 282459000625 active site 282459000626 putative substrate binding site [chemical binding]; other site 282459000627 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 282459000628 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 282459000629 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 282459000630 active site 282459000631 homodimer interface [polypeptide binding]; other site 282459000632 Pfam match to entry PF02350 Epimerase_2, UDP-N-acetylglucosamine 2-epimerase, score 577.0, E-value 1.2e-170 282459000633 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 282459000634 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 282459000635 12 probable transmembrane helices predicted for SAS0132 by TMHMM2.0 at aa 5-22, 27-44, 56-75, 90-112, 125-147, 174-196, 208-227, 231-248, 255-273, 376-398, 411-428 and 432-454 282459000636 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 282459000637 trimer interface [polypeptide binding]; other site 282459000638 active site 282459000639 substrate binding site [chemical binding]; other site 282459000640 CoA binding site [chemical binding]; other site 282459000641 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 8.3, E-value 9.6 282459000642 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 11.3, E-value 2.5 282459000643 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 11.8, E-value 1.7 282459000644 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 282459000645 Pfam match to entry PF01943 Polysacc_synt, Polysaccharide biosynthesis protein, score 14.2, E-value 2.6e-05 282459000646 12 probable transmembrane helices predicted for SAS0134 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 106-128, 141-163, 167-186, 217-236, 240-262, 283-305, 320-342, 354-371 and 381-403 282459000647 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 282459000648 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 282459000649 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 11.6, E-value 1.2e-05 282459000650 Bacterial sugar transferase; Region: Bac_transf; pfam02397 282459000651 Pfam match to entry PF02397 Bact_transf, Bacterial sugar transferase, score 143.7, E-value 3.4e-40 282459000652 1 probable transmembrane helix predicted for SAS0136 by TMHMM2.0 at aa 7-28 282459000653 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 282459000654 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 282459000655 putative NAD(P) binding site [chemical binding]; other site 282459000656 active site 282459000657 putative substrate binding site [chemical binding]; other site 282459000658 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 282459000659 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 282459000660 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 282459000661 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 282459000662 Pfam match to entry PF03721 UDPG_MGDP_dh_N, UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain, score 308.0, E-value 1.2e-89 282459000663 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 282459000664 Pfam match to entry PF00984 UDPG_MGDP_dh, UDP-glucose/GDP-mannose dehydrogenase family, central domain, score 167.8, E-value 1.9e-47 282459000665 Pfam match to entry PF03720 UDPG_MGDP_dh_C, UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain, score 123.6, E-value 3.9e-34 282459000666 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 282459000667 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 282459000668 active site 282459000669 homodimer interface [polypeptide binding]; other site 282459000670 Pfam match to entry PF02350 Epimerase_2, UDP-N-acetylglucosamine 2-epimerase, score 654.7, E-value 5.1e-194 282459000671 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 282459000672 Pfam match to entry PF03992 ABM, Antibiotic biosynthesis monooxygenase, score 49.5, E-value 7.7e-12 282459000673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 282459000674 Signal peptide predicted for SAS0141 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.348 between residues 32 and 33; signal peptide 282459000675 Pfam match to entry PF04304 DUF454, Protein of unknown function (DUF454), score 133.5, E-value 4.1e-37 282459000676 3 probable transmembrane helices predicted for SAS0141 by TMHMM2.0 at aa 4-38, 76-93 and 98-115 282459000677 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 282459000678 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 282459000679 NAD(P) binding site [chemical binding]; other site 282459000680 catalytic residues [active] 282459000681 Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family, score 703.2, E-value 1.2e-208 282459000682 PS00687 Aldehyde dehydrogenases glutamic acid active site. 282459000683 PS00070 Aldehyde dehydrogenases cysteine active site. 282459000684 Signal peptide predicted for SAS0143 by SignalP 2.0 HMM (Signal peptide probabilty 0.768) with cleavage site probability 0.292 between residues 56 and 57; signal peptide 282459000685 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 282459000686 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 282459000687 6 probable transmembrane helices predicted for SAS0143 by TMHMM2.0 at aa 30-52, 62-81, 94-116, 131-153, 166-188 and 192-209 282459000688 Pfam match to entry PF01545 Cation_efflux, Cation efflux family, score 387.7, E-value 1.2e-113 282459000689 PS00430 TonB-dependent receptor proteins signature 1. 282459000690 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 282459000691 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 282459000692 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 282459000693 Walker A/P-loop; other site 282459000694 ATP binding site [chemical binding]; other site 282459000695 Q-loop/lid; other site 282459000696 ABC transporter signature motif; other site 282459000697 Walker B; other site 282459000698 D-loop; other site 282459000699 H-loop/switch region; other site 282459000700 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 187.9, E-value 1.6e-53 282459000701 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000702 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 282459000703 NMT1-like family; Region: NMT1_2; pfam13379 282459000704 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459000705 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 282459000706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 282459000707 6 probable transmembrane helices predicted for SAS0149 by TMHMM2.0 at aa 9-31, 35-57, 64-86, 116-138, 180-202 and 222-241 282459000708 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000709 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 93.4, E-value 4.8e-25 282459000710 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 282459000711 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 282459000712 active site 282459000713 Uncharacterized conserved protein [Function unknown]; Region: COG5609 282459000714 formate dehydrogenase; Provisional; Region: PRK07574 282459000715 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 282459000716 dimerization interface [polypeptide binding]; other site 282459000717 ligand binding site [chemical binding]; other site 282459000718 NAD binding site [chemical binding]; other site 282459000719 catalytic site [active] 282459000720 Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 96.5, E-value 5.6e-26 282459000721 Pfam match to entry PF02826 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 245.4, E-value 8.3e-71 282459000722 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 282459000723 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 282459000724 putative transporter; Provisional; Region: PRK10054 282459000725 12 probable transmembrane helices predicted for SAS0153 by TMHMM2.0 at aa 13-32, 42-64, 71-90, 95-114, 135-157, 162-184, 225-247, 270-292, 299-316, 320-342, 355-377 and 387-409 282459000726 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 282459000727 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 282459000728 acyl-activating enzyme (AAE) consensus motif; other site 282459000729 AMP binding site [chemical binding]; other site 282459000730 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 282459000731 Condensation domain; Region: Condensation; pfam00668 282459000732 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 282459000733 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 282459000734 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 282459000735 acyl-activating enzyme (AAE) consensus motif; other site 282459000736 AMP binding site [chemical binding]; other site 282459000737 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 282459000738 thioester reductase domain; Region: Thioester-redct; TIGR01746 282459000739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 282459000740 NAD(P) binding site [chemical binding]; other site 282459000741 active site 282459000742 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 453.1, E-value 2.5e-133 282459000743 PS00455 AMP-binding domain signature. 282459000744 Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site, score 72.7, E-value 7.8e-19 282459000745 PS00012 Phosphopantetheine attachment site. 282459000746 Pfam match to entry PF00668 Condensation, Condensation domain, score 231.0, E-value 1.7e-66 282459000747 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 390.4, E-value 1.8e-114 282459000748 PS00697 ATP-dependent DNA ligase AMP-binding site. 282459000749 Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site, score 52.6, E-value 9.3e-13 282459000750 PS00012 Phosphopantetheine attachment site. 282459000751 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 282459000752 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 282459000753 Pfam match to entry PF01648 ACPS, 4'-phosphopantetheinyl transferase superfamily, score 15.7, E-value 0.00024 282459000754 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 282459000755 4 probable transmembrane helices predicted for SAS0156 by TMHMM2.0 at aa 7-29, 69-91, 103-125 and 140-158 282459000756 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 282459000757 nucleotide binding site [chemical binding]; other site 282459000758 N-acetyl-L-glutamate binding site [chemical binding]; other site 282459000759 Pfam match to entry PF00696 aakinase, Amino acid kinase family, score 114.4, E-value 2.2e-31 282459000760 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 282459000761 heterotetramer interface [polypeptide binding]; other site 282459000762 active site pocket [active] 282459000763 cleavage site 282459000764 Pfam match to entry PF01960 ArgJ, ArgJ family, score 656.7, E-value 1.3e-194 282459000765 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 282459000766 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 282459000767 Pfam match to entry PF02774 Semialdhyde_dhC, Semialdehyde dehydrogenase, dimerisation domain, score 161.8, E-value 1.2e-45 282459000768 PS01224 N-acetyl-gamma-glutamyl-phosphate reductase active site. 282459000769 Pfam match to entry PF01118 Semialdhyde_dh, Semialdehyde dehydrogenase, NAD binding domain, score 94.2, E-value 2.8e-25 282459000770 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 282459000771 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 282459000772 inhibitor-cofactor binding pocket; inhibition site 282459000773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459000774 catalytic residue [active] 282459000775 Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III, score 579.5, E-value 2.2e-171 282459000776 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 282459000777 Signal peptide predicted for SAS0161 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.721 between residues 36 and 37; signal peptide 282459000778 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 282459000779 Pfam match to entry PF05525 Branch_AA_trans, Branched-chain amino acid transport protein, score 802.0, E-value 2.3e-238 282459000780 12 probable transmembrane helices predicted for SAS0161 by TMHMM2.0 at aa 12-31, 41-63, 84-106, 121-140, 153-175, 195-217, 238-260, 275-297, 318-340, 344-366, 373-390 and 422-441 282459000781 Isochorismatase family; Region: Isochorismatase; pfam00857 282459000782 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 282459000783 catalytic triad [active] 282459000784 conserved cis-peptide bond; other site 282459000785 Pfam match to entry PF00857 Isochorismatase, Isochorismatase family, score 155.9, E-value 7.3e-44 282459000786 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 282459000787 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 282459000788 dimer interface [polypeptide binding]; other site 282459000789 PYR/PP interface [polypeptide binding]; other site 282459000790 TPP binding site [chemical binding]; other site 282459000791 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 282459000792 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 282459000793 TPP-binding site [chemical binding]; other site 282459000794 dimer interface [polypeptide binding]; other site 282459000795 Pfam match to entry PF02775 TPP_enzymes_C, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 155.3, E-value 1.1e-43 282459000796 Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzyme, central domain, score 17.2, E-value 2.2e-06 282459000797 Pfam match to entry PF02776 TPP_enzymes_N, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 183.0, E-value 5e-52 282459000798 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282459000799 Signal peptide predicted for SAS0164 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.406 between residues 37 and 38; signal peptide 282459000800 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 282459000801 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282459000802 active site turn [active] 282459000803 phosphorylation site [posttranslational modification] 282459000804 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 282459000805 HPr interaction site; other site 282459000806 glycerol kinase (GK) interaction site [polypeptide binding]; other site 282459000807 active site 282459000808 phosphorylation site [posttranslational modification] 282459000809 Pfam match to entry PF00358 PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1, score 241.4, E-value 1.3e-69 282459000810 PS00371 PTS EIIA domains phosphorylation site signature 1. 282459000811 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 67.8, E-value 2.4e-17 282459000812 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282459000813 10 probable transmembrane helices predicted for SAS0164 by TMHMM2.0 at aa 12-34, 74-96, 126-148, 170-192, 197-219, 278-296, 303-321, 326-348, 355-374 and 380-402 282459000814 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 400.9, E-value 1.3e-117 282459000815 Uncharacterized conserved protein [Function unknown]; Region: COG3589 282459000816 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 282459000817 Pfam match to entry PF05913 DUF871, Bacterial protein of unknown function (DUF871), score 647.6, E-value 6.8e-192 282459000818 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 282459000819 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 282459000820 putative active site [active] 282459000821 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000822 PS01272 Glucokinase regulatory protein family signature. 282459000823 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 282459000824 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282459000825 active site turn [active] 282459000826 phosphorylation site [posttranslational modification] 282459000827 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282459000828 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 59.6, E-value 7.2e-15 282459000829 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282459000830 10 probable transmembrane helices predicted for SAS0167 by TMHMM2.0 at aa 132-154, 169-191, 204-226, 236-255, 268-290, 305-327, 347-369, 384-401, 408-430 and 450-472 282459000831 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 134.0, E-value 2.8e-37 282459000832 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 282459000833 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 282459000834 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 282459000835 putative active site [active] 282459000836 Pfam match to entry PF01418 HTH_6, Helix-turn-helix domain, rpiR family, score 100.8, E-value 2.7e-27 282459000837 Pfam match to entry PF01380 SIS, SIS domain, score 19.5, E-value 0.0016 282459000838 3 probable transmembrane helices predicted for SAS0169 by TMHMM2.0 at aa 2-20, 30-52 and 65-87 282459000839 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 282459000840 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 282459000841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282459000842 ATP binding site [chemical binding]; other site 282459000843 putative Mg++ binding site [ion binding]; other site 282459000844 Pfam match to entry PF04313 HSDR_N, Type I restriction enzyme R protein N terminus (HSDR_N), score 168.9, E-value 9e-48 282459000845 5 probable transmembrane helices predicted for SAS0171 by TMHMM2.0 at aa 21-43, 70-92, 105-127, 147-169 and 176-198 282459000846 Signal peptide predicted for SAS0172 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.343 between residues 34 and 35; signal peptide 282459000847 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 282459000848 1 probable transmembrane helix predicted for SAS0172 by TMHMM2.0 at aa 7-24 282459000849 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 282459000850 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282459000851 Walker A/P-loop; other site 282459000852 ATP binding site [chemical binding]; other site 282459000853 Q-loop/lid; other site 282459000854 ABC transporter signature motif; other site 282459000855 Walker B; other site 282459000856 D-loop; other site 282459000857 H-loop/switch region; other site 282459000858 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 191.2, E-value 1.7e-54 282459000859 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000860 PS00211 ABC transporters family signature. 282459000861 Signal peptide predicted for SAS0174 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.627 between residues 47 and 48; signal peptide 282459000862 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 282459000863 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 282459000864 FtsX-like permease family; Region: FtsX; pfam02687 282459000865 4 probable transmembrane helices predicted for SAS0174 by TMHMM2.0 at aa 20-42, 266-288, 317-339 and 354-376 282459000866 Pfam match to entry PF02687 FtsX, Predicted permease, score 143.8, E-value 3.3e-40 282459000867 Signal peptide predicted for SAS0175 by SignalP 2.0 HMM (Signal peptide probabilty 0.809) with cleavage site probability 0.503 between residues 51 and 52; signal peptide 282459000868 1 probable transmembrane helix predicted for SAS0175 by TMHMM2.0 at aa 31-53 282459000869 12 probable transmembrane helices predicted for SAS0176 by TMHMM2.0 at aa 48-67, 77-96, 135-157, 161-183, 196-218, 275-297, 309-331, 346-365, 372-391, 428-450, 455-477 and 532-554 282459000870 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 282459000871 3 probable transmembrane helices predicted for SAS0177 by TMHMM2.0 at aa 33-55, 84-106 and 119-141 282459000872 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 282459000873 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 282459000874 Walker A/P-loop; other site 282459000875 ATP binding site [chemical binding]; other site 282459000876 Q-loop/lid; other site 282459000877 ABC transporter signature motif; other site 282459000878 Walker B; other site 282459000879 D-loop; other site 282459000880 H-loop/switch region; other site 282459000881 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 150.8, E-value 2.5e-42 282459000882 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000883 PS00211 ABC transporters family signature. 282459000884 2 probable transmembrane helices predicted for SAS0179 by TMHMM2.0 at aa 7-24 and 29-51 282459000885 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 282459000886 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282459000887 Walker A/P-loop; other site 282459000888 ATP binding site [chemical binding]; other site 282459000889 Q-loop/lid; other site 282459000890 ABC transporter signature motif; other site 282459000891 Walker B; other site 282459000892 D-loop; other site 282459000893 H-loop/switch region; other site 282459000894 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 282459000895 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282459000896 Walker A/P-loop; other site 282459000897 ATP binding site [chemical binding]; other site 282459000898 Q-loop/lid; other site 282459000899 ABC transporter signature motif; other site 282459000900 Walker B; other site 282459000901 D-loop; other site 282459000902 H-loop/switch region; other site 282459000903 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 220.6, E-value 2.4e-63 282459000904 PS00211 ABC transporters family signature. 282459000905 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000906 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 211.0, E-value 1.9e-60 282459000907 PS00211 ABC transporters family signature. 282459000908 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000909 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 282459000910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459000911 dimer interface [polypeptide binding]; other site 282459000912 conserved gate region; other site 282459000913 putative PBP binding loops; other site 282459000914 ABC-ATPase subunit interface; other site 282459000915 8 probable transmembrane helices predicted for SAS0182 by TMHMM2.0 at aa 7-29, 103-125, 132-154, 221-243, 256-278, 293-315, 351-373 and 401-423 282459000916 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 178.5, E-value 1.1e-50 282459000917 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 282459000918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459000919 dimer interface [polypeptide binding]; other site 282459000920 conserved gate region; other site 282459000921 ABC-ATPase subunit interface; other site 282459000922 9 probable transmembrane helices predicted for SAS0183 by TMHMM2.0 at aa 15-34, 41-60, 75-97, 125-147, 193-215, 228-247, 251-273, 311-333 and 353-375 282459000923 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 150.7, E-value 2.7e-42 282459000924 Signal peptide predicted for SAS0184 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.666 between residues 27 and 28; signal peptide 282459000925 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 282459000926 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 282459000927 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 282459000928 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459000929 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 282459000930 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 282459000931 Pfam match to entry PF01019 G_glu_transpept, Gamma-glutamyltranspeptidase, score 754.6, E-value 4.3e-224 282459000932 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742 282459000933 Pfam match to entry PF04507 DUF576, Protein of unknown function, DUF576, score 483.8, E-value 1.4e-142 282459000934 1 probable transmembrane helix predicted for SAS0186 by TMHMM2.0 at aa 7-29 282459000935 azoreductase; Reviewed; Region: PRK00170 282459000936 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 282459000937 Pfam match to entry PF02525 Flavodoxin_2, Flavodoxin-like fold, score 176.7, E-value 3.9e-50 282459000938 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000939 Signal peptide predicted for SAS0188 by SignalP 2.0 HMM (Signal peptide probabilty 0.938) with cleavage site probability 0.645 between residues 24 and 25; signal peptide 282459000940 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 282459000941 Peptidase family M23; Region: Peptidase_M23; pfam01551 282459000942 1 probable transmembrane helix predicted for SAS0188 by TMHMM2.0 at aa 7-25 282459000943 Pfam match to entry PF01551 Peptidase_M37, Peptidase family M23/M37, score 96.1, E-value 7.4e-26 282459000944 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 282459000945 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 282459000946 Walker A/P-loop; other site 282459000947 ATP binding site [chemical binding]; other site 282459000948 Q-loop/lid; other site 282459000949 ABC transporter signature motif; other site 282459000950 Walker B; other site 282459000951 D-loop; other site 282459000952 H-loop/switch region; other site 282459000953 TOBE domain; Region: TOBE; pfam03459 282459000954 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 222.2, E-value 8.1e-64 282459000955 PS00017 ATP/GTP-binding site motif A (P-loop). 282459000956 PS00211 ABC transporters family signature. 282459000957 Pfam match to entry PF03459 TOBE, TOBE domain, score 44.1, E-value 3.2e-10 282459000958 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 282459000959 Signal peptide predicted for SAS0190 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.954 between residues 28 and 29; signal peptide 282459000960 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 282459000961 Pfam match to entry PF01547 SBP_bac_1, Bacterial extracellular solute-binding protein, score 83.9, E-value 3.5e-22 282459000962 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459000963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459000964 dimer interface [polypeptide binding]; other site 282459000965 conserved gate region; other site 282459000966 ABC-ATPase subunit interface; other site 282459000967 Pfam match to entry PF05154 TM2, TM2 domain, score 64.1, E-value 3.1e-16 282459000968 8 probable transmembrane helices predicted for SAS0191 by TMHMM2.0 at aa 31-53, 68-90, 122-144, 192-214, 227-249, 279-301, 326-345 and 388-410 282459000969 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 73.8, E-value 3.7e-19 282459000970 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282459000971 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 282459000972 Signal peptide predicted for SAS0192 by SignalP 2.0 HMM (Signal peptide probabilty 0.806) with cleavage site probability 0.559 between residues 44 and 45; signal peptide 282459000973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459000974 dimer interface [polypeptide binding]; other site 282459000975 conserved gate region; other site 282459000976 putative PBP binding loops; other site 282459000977 ABC-ATPase subunit interface; other site 282459000978 6 probable transmembrane helices predicted for SAS0192 by TMHMM2.0 at aa 12-34, 75-97, 109-131, 141-163, 184-206 and 242-264 282459000979 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 72.0, E-value 1.3e-18 282459000980 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282459000981 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 282459000982 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 282459000983 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 282459000984 Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase family, NAD-binding Rossmann fold, score 150.9, E-value 2.3e-42 282459000985 Pfam match to entry PF02894 GFO_IDH_MocA_C, Oxidoreductase family, C-terminal alpha/beta domain, score 9.9, E-value 0.035 282459000986 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 282459000987 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 282459000988 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 282459000989 Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase family, NAD-binding Rossmann fold, score 144.0, E-value 2.7e-40 282459000990 Pfam match to entry PF02894 GFO_IDH_MocA_C, Oxidoreductase family, C-terminal alpha/beta domain, score 30.0, E-value 5.6e-06 282459000991 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 282459000992 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 282459000993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 282459000994 Pfam match to entry PF04140 ICMT, Isoprenylcysteine carboxyl methyltransferase (ICMT) family, score 167.5, E-value 2.4e-47 282459000995 3 probable transmembrane helices predicted for SAS0196 by TMHMM2.0 at aa 43-60, 65-87 and 131-153 282459000996 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 282459000997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459000998 putative substrate translocation pore; other site 282459000999 12 probable transmembrane helices predicted for SAS0197 by TMHMM2.0 at aa 22-44, 64-86, 99-121, 125-147, 160-180, 190-212, 252-274, 294-316, 325-344, 354-376, 389-408 and 428-450 282459001000 PS00942 glpT family of transporters signature. 282459001001 Response regulator receiver domain; Region: Response_reg; pfam00072 282459001002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459001003 active site 282459001004 phosphorylation site [posttranslational modification] 282459001005 intermolecular recognition site; other site 282459001006 dimerization interface [polypeptide binding]; other site 282459001007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 282459001008 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 282459001009 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 282459001010 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 20.3, E-value 0.0049 282459001011 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 29.8, E-value 6.7e-06 282459001012 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 80.1, E-value 4.8e-21 282459001013 Signal peptide predicted for SAS0199 by SignalP 2.0 HMM (Signal peptide probabilty 0.978) with cleavage site probability 0.496 between residues 35 and 36; signal peptide 282459001014 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 282459001015 Histidine kinase; Region: His_kinase; pfam06580 282459001016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459001017 ATP binding site [chemical binding]; other site 282459001018 Mg2+ binding site [ion binding]; other site 282459001019 G-X-G motif; other site 282459001020 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 11.2, E-value 0.0056 282459001021 2 probable transmembrane helices predicted for SAS0199 by TMHMM2.0 at aa 15-37 and 222-244 282459001022 Signal peptide predicted for SAS0200 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.739 between residues 24 and 25; signal peptide 282459001023 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 282459001024 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 282459001025 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459001026 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 282459001027 Pyruvate formate lyase 1; Region: PFL1; cd01678 282459001028 coenzyme A binding site [chemical binding]; other site 282459001029 active site 282459001030 catalytic residues [active] 282459001031 glycine loop; other site 282459001032 Pfam match to entry PF02901 PFL, Pyruvate formate lyase, score 1146.0, E-value 0 282459001033 Pfam match to entry PF01228 Gly_radical, Glycine radical, score 169.5, E-value 6e-48 282459001034 PS00850 Glycine radical signature. 282459001035 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 282459001036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282459001037 FeS/SAM binding site; other site 282459001038 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 282459001039 PS01087 Radical activating enzymes signature. 282459001040 Pfam match to entry PF04055 Radical_SAM, Radical SAM superfamily, score 99.4, E-value 7.5e-27 282459001041 PS00190 Cytochrome c family heme-binding site signature. 282459001042 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 282459001043 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 282459001044 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 282459001045 putative active site [active] 282459001046 catalytic site [active] 282459001047 putative metal binding site [ion binding]; other site 282459001048 7 probable transmembrane helices predicted for SAS0204 by TMHMM2.0 at aa 21-43, 70-101, 122-144, 174-196, 223-245, 255-274 and 312-334 282459001049 Pfam match to entry PF03009 GDPD, Glycerophosphoryl diester phosphodiesterase family, score 93.8, E-value 3.7e-25 282459001050 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 282459001051 Signal peptide predicted for SAS0206 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.978 between residues 26 and 27; signal peptide 282459001052 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 282459001053 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 282459001054 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 282459001055 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 282459001056 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 282459001057 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 282459001058 PS00429 Staphylocoagulase repeat signature. 282459001059 Pfam match to entry PF04022 Staphylcoagulse, Staphylocoagulase repeat, score 57.3, E-value 3.4e-14 282459001060 Pfam match to entry PF04022 Staphylcoagulse, Staphylocoagulase repeat, score 54.4, E-value 2.6e-13 282459001061 PS00429 Staphylocoagulase repeat signature. 282459001062 Pfam match to entry PF04022 Staphylcoagulse, Staphylocoagulase repeat, score 59.3, E-value 8.8e-15 282459001063 PS00429 Staphylocoagulase repeat signature. 282459001064 Pfam match to entry PF04022 Staphylcoagulse, Staphylocoagulase repeat, score 59.3, E-value 8.8e-15 282459001065 PS00429 Staphylocoagulase repeat signature. 282459001066 Pfam match to entry PF04022 Staphylcoagulse, Staphylocoagulase repeat, score 55.2, E-value 1.5e-13 282459001067 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 282459001068 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 282459001069 dimer interface [polypeptide binding]; other site 282459001070 active site 282459001071 1 probable transmembrane helix predicted for SAS0207 by TMHMM2.0 at aa 371-393 282459001072 Pfam match to entry PF02803 thiolase_C, Thiolase, C-terminal domain, score 223.3, E-value 3.8e-64 282459001073 PS00099 Thiolases active site. 282459001074 PS00737 Thiolases signature 2. 282459001075 Pfam match to entry PF00108 thiolase, Thiolase, N-terminal domain, score 325.0, E-value 9.3e-95 282459001076 PS00098 Thiolases acyl-enzyme intermediate signature. 282459001077 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 282459001078 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 282459001079 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 282459001080 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 282459001081 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 282459001082 substrate binding site [chemical binding]; other site 282459001083 oxyanion hole (OAH) forming residues; other site 282459001084 trimer interface [polypeptide binding]; other site 282459001085 Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family, score 28.0, E-value 1.7e-10 282459001086 PS00166 Enoyl-CoA hydratase/isomerase signature. 282459001087 Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain, score 103.9, E-value 3.3e-28 282459001088 Pfam match to entry PF02737 3HCDH_N, 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain, score 114.7, E-value 1.8e-31 282459001089 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 282459001090 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 282459001091 active site 282459001092 Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase, C-terminal domain, score 117.0, E-value 3.8e-32 282459001093 Pfam match to entry PF02770 Acyl-CoA_dh_M, Acyl-CoA dehydrogenase, middle domain, score 30.5, E-value 6.2e-09 282459001094 Pfam match to entry PF02771 Acyl-CoA_dh_N, Acyl-CoA dehydrogenase, N-terminal domain, score 18.7, E-value 1.8e-05 282459001095 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 282459001096 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 282459001097 acyl-activating enzyme (AAE) consensus motif; other site 282459001098 AMP binding site [chemical binding]; other site 282459001099 active site 282459001100 CoA binding site [chemical binding]; other site 282459001101 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 400.3, E-value 2e-117 282459001102 PS00455 AMP-binding domain signature. 282459001103 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 282459001104 Coenzyme A transferase; Region: CoA_trans; smart00882 282459001105 Coenzyme A transferase; Region: CoA_trans; cl17247 282459001106 Pfam match to entry PF01144 CoA_trans, Coenzyme A transferase, score 61.5, E-value 1.9e-15 282459001107 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 282459001108 8 probable transmembrane helices predicted for SAS0212 by TMHMM2.0 at aa 107-129, 134-156, 169-191, 206-228, 235-257, 272-294, 314-332 and 342-361 282459001109 Signal peptide predicted for SAS0213 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.826 between residues 26 and 27; signal peptide 282459001110 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 282459001111 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 282459001112 Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 59.7, E-value 6.7e-15 282459001113 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459001114 Uncharacterized conserved protein [Function unknown]; Region: COG3189 282459001115 Pfam match to entry PF04343 DUF488, Protein of unknown function, DUF488, score 155.7, E-value 8.6e-44 282459001116 2 probable transmembrane helices predicted for SAS0215 by TMHMM2.0 at aa 7-24 and 34-51 282459001117 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 282459001118 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 282459001119 heme-binding site [chemical binding]; other site 282459001120 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 282459001121 FAD binding pocket [chemical binding]; other site 282459001122 FAD binding motif [chemical binding]; other site 282459001123 phosphate binding motif [ion binding]; other site 282459001124 beta-alpha-beta structure motif; other site 282459001125 NAD binding pocket [chemical binding]; other site 282459001126 Heme binding pocket [chemical binding]; other site 282459001127 Pfam match to entry PF00970 FAD_binding_6, Oxidoreductase FAD-binding domain, score 34.6, E-value 7.6e-08 282459001128 Pfam match to entry PF00042 globin, Globin, score 56.1, E-value 8e-14 282459001129 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 282459001130 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 282459001131 tetramer (dimer of dimers) interface [polypeptide binding]; other site 282459001132 NAD binding site [chemical binding]; other site 282459001133 dimer interface [polypeptide binding]; other site 282459001134 substrate binding site [chemical binding]; other site 282459001135 Pfam match to entry PF00056 ldh, lactate/malate dehydrogenase, NAD binding domain, score 261.2, E-value 1.5e-75 282459001136 Pfam match to entry PF02866 ldh_C, lactate/malate dehydrogenase, alpha/beta C-terminal domain, score 287.9, E-value 1.3e-83 282459001137 PS00064 L-lactate dehydrogenase active site. 282459001138 Signal peptide predicted for SAS0218 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.705 between residues 43 and 44; signal peptide 282459001139 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 282459001140 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282459001141 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282459001142 active site turn [active] 282459001143 phosphorylation site [posttranslational modification] 282459001144 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 54.4, E-value 2.5e-13 282459001145 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282459001146 11 probable transmembrane helices predicted for SAS0218 by TMHMM2.0 at aa 15-37, 58-80, 93-115, 128-150, 170-192, 199-221, 280-302, 309-327, 332-354, 361-383 and 388-410 282459001147 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 382.5, E-value 4.3e-112 282459001148 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 282459001149 active site 282459001150 tetramer interface [polypeptide binding]; other site 282459001151 Pfam match to entry PF01156 IU_nuc_hydro, Inosine-uridine preferring nucleoside hydrolase, score 375.7, E-value 4.9e-110 282459001152 PS01247 Inosine-uridine preferring nucleoside hydrolase family signature. 282459001153 PS00018 EF-hand calcium-binding domain. 282459001154 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 282459001155 Mga helix-turn-helix domain; Region: Mga; pfam05043 282459001156 PRD domain; Region: PRD; pfam00874 282459001157 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 282459001158 active site 282459001159 P-loop; other site 282459001160 phosphorylation site [posttranslational modification] 282459001161 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282459001162 active site 282459001163 phosphorylation site [posttranslational modification] 282459001164 Predicted helix-turn-helix motif for SAS0220 with score 1056.000, SD 2.78 at aa 25-46, sequence IHGKELESIFGLSRRQLGYRIQ 282459001165 Pfam match to entry PF00874 PRD, PRD domain, score 97.5, E-value 2.7e-26 282459001166 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 3.9, E-value 4.2e-06 282459001167 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282459001168 active site 282459001169 phosphorylation site [posttranslational modification] 282459001170 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 47.8, E-value 2.6e-11 282459001171 Signal peptide predicted for SAS0222 by SignalP 2.0 HMM (Signal peptide probabilty 0.859) with cleavage site probability 0.422 between residues 26 and 27; signal peptide 282459001172 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 282459001173 active site 282459001174 P-loop; other site 282459001175 phosphorylation site [posttranslational modification] 282459001176 Pfam match to entry PF02302 PTS_IIB, PTS system, Lactose/Cellobiose specific IIB subunit, score 95.1, E-value 1.4e-25 282459001177 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 282459001178 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 282459001179 9 probable transmembrane helices predicted for SAS0223 by TMHMM2.0 at aa 10-31, 38-60, 92-114, 135-157, 177-199, 220-242, 303-325, 330-352 and 357-379 282459001180 Pfam match to entry PF03611 EIIC-GAT, PTS system Galactitol-specific IIC component, score 717.9, E-value 4.8e-213 282459001181 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 282459001182 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 282459001183 putative NAD(P) binding site [chemical binding]; other site 282459001184 catalytic Zn binding site [ion binding]; other site 282459001185 structural Zn binding site [ion binding]; other site 282459001186 Pfam match to entry PF00107 ADH_zinc_N, Zinc-binding dehydrogenase, score 334.1, E-value 1.6e-97 282459001187 PS00059 Zinc-containing alcohol dehydrogenases signature. 282459001188 1 probable transmembrane helix predicted for SAS0225 by TMHMM2.0 at aa 19-41 282459001189 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 282459001190 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 282459001191 putative NAD(P) binding site [chemical binding]; other site 282459001192 catalytic Zn binding site [ion binding]; other site 282459001193 Pfam match to entry PF00107 ADH_zinc_N, Zinc-binding dehydrogenase, score 297.0, E-value 2.4e-86 282459001194 PS00059 Zinc-containing alcohol dehydrogenases signature. 282459001195 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 282459001196 substrate binding site; other site 282459001197 dimer interface; other site 282459001198 Pfam match to entry PF01128 IspD, Uncharacterized protein family UPF0007, score 98.8, E-value 1.1e-26 282459001199 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 282459001200 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 282459001201 putative NAD(P) binding site [chemical binding]; other site 282459001202 putative catalytic Zn binding site [ion binding]; other site 282459001203 Pfam match to entry PF00107 ADH_zinc_N, Zinc-binding dehydrogenase, score 39.3, E-value 5e-10 282459001204 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 282459001205 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 282459001206 Pfam match to entry PF04464 glyphos_transf, CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase, score 279.1, E-value 5.9e-81 282459001207 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 282459001208 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 282459001209 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 282459001210 Pfam match to entry PF04464 glyphos_transf, CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase, score 329.6, E-value 3.8e-96 282459001211 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 282459001212 substrate binding site; other site 282459001213 dimer interface; other site 282459001214 Pfam match to entry PF01128 IspD, Uncharacterized protein family UPF0007, score 89.6, E-value 6.4e-24 282459001215 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 282459001216 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 282459001217 putative NAD(P) binding site [chemical binding]; other site 282459001218 putative catalytic Zn binding site [ion binding]; other site 282459001219 Pfam match to entry PF00107 ADH_zinc_N, Zinc-binding dehydrogenase, score 30.1, E-value 1.7e-09 282459001220 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 282459001221 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 282459001222 Pfam match to entry PF04464 glyphos_transf, CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase, score 282.4, E-value 6e-82 282459001223 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 282459001224 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 282459001225 active site 282459001226 Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferase, score 137.6, E-value 2.3e-38 282459001227 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 282459001228 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 282459001229 Hemerythrin-like domain; Region: Hr-like; cd12108 282459001230 Fe binding site [ion binding]; other site 282459001231 Pfam match to entry PF04405 ScdA_N, Domain of Unknown function (DUF542), score 140.3, E-value 3.7e-39 282459001232 Pfam match to entry PF03794 HHE, Domain of Unknown function, score 53.2, E-value 5.9e-13 282459001233 Pfam match to entry PF03794 HHE, Domain of Unknown function, score 52.6, E-value 8.9e-13 282459001234 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 282459001235 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 282459001236 Histidine kinase; Region: His_kinase; pfam06580 282459001237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459001238 Mg2+ binding site [ion binding]; other site 282459001239 G-X-G motif; other site 282459001240 6 probable transmembrane helices predicted for SAS0237 by TMHMM2.0 at aa 6-28, 40-62, 88-110, 123-140, 155-172 and 184-206 282459001241 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 282459001242 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 56.7, E-value 5.2e-14 282459001243 two-component response regulator; Provisional; Region: PRK14084 282459001244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459001245 active site 282459001246 phosphorylation site [posttranslational modification] 282459001247 intermolecular recognition site; other site 282459001248 dimerization interface [polypeptide binding]; other site 282459001249 LytTr DNA-binding domain; Region: LytTR; pfam04397 282459001250 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 112.0, E-value 1.2e-30 282459001251 Pfam match to entry PF04397 LytTR, LytTr DNA-binding domain, score 115.5, E-value 1.1e-31 282459001252 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 282459001253 4 probable transmembrane helices predicted for SAS0239 by TMHMM2.0 at aa 13-32, 42-64, 71-93 and 97-119 282459001254 Pfam match to entry PF03788 LrgA, LrgA family, score 103.2, E-value 5.5e-28 282459001255 antiholin-like protein LrgB; Provisional; Region: PRK04288 282459001256 7 probable transmembrane helices predicted for SAS0240 by TMHMM2.0 at aa 5-27, 34-56, 67-84, 97-116, 126-148, 155-177 and 210-232 282459001257 Pfam match to entry PF04172 LrgB, LrgB-like family, score 384.9, E-value 8.6e-113 282459001258 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 282459001259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 282459001260 DNA-binding site [nucleotide binding]; DNA binding site 282459001261 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 282459001262 Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 57.5, E-value 3e-14 282459001263 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 282459001264 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 282459001265 HPr interaction site; other site 282459001266 glycerol kinase (GK) interaction site [polypeptide binding]; other site 282459001267 active site 282459001268 phosphorylation site [posttranslational modification] 282459001269 Pfam match to entry PF00358 PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1, score 124.6, E-value 2e-34 282459001270 PS00371 PTS EIIA domains phosphorylation site signature 1. 282459001271 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 282459001272 beta-galactosidase; Region: BGL; TIGR03356 282459001273 Pfam match to entry PF00232 Glyco_hydro_1, Glycosyl hydrolase family 1, score 490.2, E-value 1.6e-144 282459001274 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 282459001275 PS00572 Glycosyl hydrolases family 1 active site. 282459001276 Methyltransferase domain; Region: Methyltransf_31; pfam13847 282459001277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459001278 S-adenosylmethionine binding site [chemical binding]; other site 282459001279 Pfam match to entry PF01209 Ubie_methyltran, ubiE/COQ5 methyltransferase family, score 20.4, E-value 5.2e-06 282459001280 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 282459001281 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 282459001282 substrate binding site [chemical binding]; other site 282459001283 dimer interface [polypeptide binding]; other site 282459001284 ATP binding site [chemical binding]; other site 282459001285 Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 265.0, E-value 1.1e-76 282459001286 PS00584 pfkB family of carbohydrate kinases signature 2. 282459001287 D-ribose pyranase; Provisional; Region: PRK11797 282459001288 Pfam match to entry PF05025 RbsD_FucU, RbsD / FucU transport protein family, score 269.9, E-value 3.5e-78 282459001289 Signal peptide predicted for SAS0247 by SignalP 2.0 HMM (Signal peptide probabilty 0.929) with cleavage site probability 0.463 between residues 25 and 26; signal peptide 282459001290 Sugar transport protein; Region: Sugar_transport; pfam06800 282459001291 10 probable transmembrane helices predicted for SAS0247 by TMHMM2.0 at aa 2-24, 34-56, 63-80, 95-117, 122-139, 154-171, 180-202, 212-234, 241-263 and 273-292 282459001292 Transcriptional regulators [Transcription]; Region: PurR; COG1609 282459001293 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 282459001294 DNA binding site [nucleotide binding] 282459001295 domain linker motif; other site 282459001296 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 282459001297 dimerization interface [polypeptide binding]; other site 282459001298 ligand binding site [chemical binding]; other site 282459001299 Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family, score 43.8, E-value 4.2e-10 282459001300 Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, score 48.0, E-value 2.3e-11 282459001301 Predicted helix-turn-helix motif for SAS0248 with score 2168.000, SD 6.57 at aa 4-25, sequence VSIKDVAREAGVSVTTVSHILN 282459001302 PS00356 Bacterial regulatory proteins, lacI family signature. 282459001303 Signal peptide predicted for SAS0250 by SignalP 2.0 HMM (Signal peptide probabilty 0.938) with cleavage site probability 0.705 between residues 58 and 59; signal peptide 282459001304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459001305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459001306 14 probable transmembrane helices predicted for SAS0250 by TMHMM2.0 at aa 12-34, 44-66, 79-98, 102-124, 137-159, 163-182, 202-221, 225-247, 268-290, 300-319, 326-348, 353-375, 396-418 and 428-450 282459001307 PS00962 Ribosomal protein S2 signature 1. 282459001308 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 282459001309 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 282459001310 active site 282459001311 Pfam match to entry PF02275 CBAH, Linear amide C-N hydrolases, choloylglycine hydrolase family, score 225.4, E-value 8.8e-65 282459001312 Signal peptide predicted for SAS0252 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.766 between residues 25 and 26; signal peptide 282459001313 Surface antigen [General function prediction only]; Region: COG3942 282459001314 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 282459001315 Peptidase family M23; Region: Peptidase_M23; pfam01551 282459001316 Pfam match to entry PF01551 Peptidase_M37, Peptidase family M23/M37, score 141.6, E-value 1.4e-39 282459001317 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 282459001318 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 282459001319 Walker A/P-loop; other site 282459001320 ATP binding site [chemical binding]; other site 282459001321 Q-loop/lid; other site 282459001322 ABC transporter signature motif; other site 282459001323 Walker B; other site 282459001324 D-loop; other site 282459001325 H-loop/switch region; other site 282459001326 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 158.7, E-value 1e-44 282459001327 PS00211 ABC transporters family signature. 282459001328 PS00017 ATP/GTP-binding site motif A (P-loop). 282459001329 5 probable transmembrane helices predicted for SAS0254 by TMHMM2.0 at aa 15-37, 185-207, 227-249, 256-278 and 283-305 282459001330 Signal peptide predicted for SAS0255 by SignalP 2.0 HMM (Signal peptide probabilty 0.980) with cleavage site probability 0.974 between residues 43 and 44; signal peptide 282459001331 6 probable transmembrane helices predicted for SAS0255 by TMHMM2.0 at aa 20-42, 199-221, 242-264, 279-301, 313-335 and 367-384 282459001332 Signal peptide predicted for SAS0256 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.803 between residues 30 and 31; signal peptide 282459001333 1 probable transmembrane helix predicted for SAS0256 by TMHMM2.0 at aa 7-29 282459001334 Signal peptide predicted for SAS0257 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.787 between residues 27 and 28; signal peptide 282459001335 Surface antigen [General function prediction only]; Region: COG3942 282459001336 CHAP domain; Region: CHAP; pfam05257 282459001337 Pfam match to entry PF05257 CHAP, CHAP domain, score 164.5, E-value 1.8e-46 282459001338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 282459001339 Pfam match to entry PF06013 DUF909, Bacterial protein of unknown function (DUF909), score 155.6, E-value 8.7e-44 282459001340 Signal peptide predicted for SAS0259 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.605 between residues 27 and 28; signal peptide 282459001341 Predicted membrane protein [Function unknown]; Region: COG1511 282459001342 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 282459001343 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 282459001344 6 probable transmembrane helices predicted for SAS0259 by TMHMM2.0 at aa 5-27, 821-843, 864-886, 901-923, 928-945 and 978-1000 282459001345 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 282459001346 1 probable transmembrane helix predicted for SAS0260 by TMHMM2.0 at aa 115-137 282459001347 Uncharacterized small protein [Function unknown]; Region: COG5417 282459001348 Predicted membrane protein [Function unknown]; Region: COG4499 282459001349 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 282459001350 1 probable transmembrane helix predicted for SAS0262 by TMHMM2.0 at aa 229-251 282459001351 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 282459001352 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 282459001353 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 282459001354 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 282459001355 2 probable transmembrane helices predicted for SAS0263 by TMHMM2.0 at aa 230-252 and 257-279 282459001356 Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family, score 145.0, E-value 1.4e-40 282459001357 PS00017 ATP/GTP-binding site motif A (P-loop). 282459001358 Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family, score 110.5, E-value 3.5e-30 282459001359 PS00430 TonB-dependent receptor proteins signature 1. 282459001360 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 282459001361 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 282459001362 Uncharacterized conserved protein [Function unknown]; Region: COG5444 282459001363 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 282459001364 Protein of unknown function, DUF600; Region: DUF600; cl04640 282459001365 Pfam match to entry PF04634 DUF600, Protein of unknown function, DUF600, score 356.6, E-value 2.8e-104 282459001366 6 probable transmembrane helices predicted for SAS0270 by TMHMM2.0 at aa 15-37, 44-65, 85-107, 119-141, 161-183 and 190-212 282459001367 6 probable transmembrane helices predicted for SAS0271 by TMHMM2.0 at aa 4-21, 28-50, 60-79, 120-139, 149-171 and 178-200 282459001368 PS00251 TNF family signature. 282459001369 Protein of unknown function, DUF600; Region: DUF600; cl04640 282459001370 Pfam match to entry PF04634 DUF600, Protein of unknown function, DUF600, score 339.7, E-value 3.5e-99 282459001371 Protein of unknown function, DUF600; Region: DUF600; cl04640 282459001372 Pfam match to entry PF04634 DUF600, Protein of unknown function, DUF600, score 306.8, E-value 2.8e-89 282459001373 Protein of unknown function, DUF600; Region: DUF600; cl04640 282459001374 Pfam match to entry PF04634 DUF600, Protein of unknown function, DUF600, score 354.6, E-value 1.1e-103 282459001375 Protein of unknown function, DUF600; Region: DUF600; cl04640 282459001376 Pfam match to entry PF04634 DUF600, Protein of unknown function, DUF600, score 343.8, E-value 2e-100 282459001377 Protein of unknown function, DUF600; Region: DUF600; cl04640 282459001378 Pfam match to entry PF04634 DUF600, Protein of unknown function, DUF600, score 334.5, E-value 1.2e-97 282459001379 Protein of unknown function, DUF600; Region: DUF600; cl04640 282459001380 Pfam match to entry PF04634 DUF600, Protein of unknown function, DUF600, score 346.5, E-value 3e-101 282459001381 Protein of unknown function, DUF600; Region: DUF600; cl04640 282459001382 Pfam match to entry PF04634 DUF600, Protein of unknown function, DUF600, score 329.3, E-value 4.6e-96 282459001383 Protein of unknown function, DUF600; Region: DUF600; cl04640 282459001384 Pfam match to entry PF04634 DUF600, Protein of unknown function, DUF600, score 353.9, E-value 1.8e-103 282459001385 Signal peptide predicted for SAS0280 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.440 between residues 25 and 26; signal peptide 282459001386 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 282459001387 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459001388 Signal peptide predicted for SAS0281 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.456 between residues 30 and 31; signal peptide 282459001389 3 probable transmembrane helices predicted for SAS0281 by TMHMM2.0 at aa 7-29, 57-79 and 91-113 282459001390 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 282459001391 Pfam match to entry PF01226 Form_Nir_trans, Formate/nitrite transporter, score 57.4, E-value 3.2e-14 282459001392 6 probable transmembrane helices predicted for SAS0282 by TMHMM2.0 at aa 38-60, 75-97, 117-139, 165-187, 194-216 and 242-264 282459001393 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 282459001394 Signal peptide predicted for SAS0283 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.391 between residues 31 and 32; signal peptide 282459001395 Pfam match to entry PF05525 Branch_AA_trans, Branched-chain amino acid transport protein, score 785.4, E-value 2.3e-233 282459001396 12 probable transmembrane helices predicted for SAS0283 by TMHMM2.0 at aa 5-27, 37-59, 72-94, 109-131, 143-165, 189-211, 223-245, 275-297, 310-332, 336-358, 371-393 and 408-427 282459001397 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 282459001398 Signal peptide predicted for SAS0284 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.972 between residues 31 and 32; signal peptide 282459001399 Pfam match to entry PF03767 acid_phosphat_B, HAD superfamily, subfamily IIIB (Acid phosphatase), score 292.9, E-value 4.1e-85 282459001400 Signal peptide predicted for SAS0285 by SignalP 2.0 HMM (Signal peptide probabilty 0.775) with cleavage site probability 0.505 between residues 36 and 37; signal peptide 282459001401 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 282459001402 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 282459001403 FtsX-like permease family; Region: FtsX; pfam02687 282459001404 4 probable transmembrane helices predicted for SAS0285 by TMHMM2.0 at aa 13-35, 230-252, 273-295 and 315-337 282459001405 Pfam match to entry PF02687 FtsX, Predicted permease, score 71.4, E-value 2.1e-18 282459001406 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 282459001407 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282459001408 Walker A/P-loop; other site 282459001409 ATP binding site [chemical binding]; other site 282459001410 Q-loop/lid; other site 282459001411 ABC transporter signature motif; other site 282459001412 Walker B; other site 282459001413 D-loop; other site 282459001414 H-loop/switch region; other site 282459001415 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 181.2, E-value 1.8e-51 282459001416 PS00017 ATP/GTP-binding site motif A (P-loop). 282459001417 PS00211 ABC transporters family signature. 282459001418 Signal peptide predicted for SAS0287 by SignalP 2.0 HMM (Signal peptide probabilty 0.912) with cleavage site probability 0.427 between residues 37 and 38; signal peptide 282459001419 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 282459001420 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 282459001421 9 probable transmembrane helices predicted for SAS0287 by TMHMM2.0 at aa 4-23, 30-47, 67-86, 93-115, 130-152, 172-191, 196-218, 254-276 and 302-324 282459001422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282459001423 non-specific DNA binding site [nucleotide binding]; other site 282459001424 salt bridge; other site 282459001425 sequence-specific DNA binding site [nucleotide binding]; other site 282459001426 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 282459001427 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 282459001428 substrate binding site [chemical binding]; other site 282459001429 ATP binding site [chemical binding]; other site 282459001430 Predicted helix-turn-helix motif for SAS0288 with score 1997.000, SD 5.99 at aa 18-39, sequence ISQRELAEAIGLSRPSVANIIS 282459001431 Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 110.0, E-value 4.8e-30 282459001432 PS00583 pfkB family of carbohydrate kinases signature 1. 282459001433 PS00584 pfkB family of carbohydrate kinases signature 2. 282459001434 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 282459001435 Pfam match to entry PF04227 Indigoidine_A, Indigoidine synthase A like protein, score 755.0, E-value 3.4e-224 282459001436 1 probable transmembrane helix predicted for SAS0289 by TMHMM2.0 at aa 103-125 282459001437 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 282459001438 Signal peptide predicted for SAS0290 by SignalP 2.0 HMM (Signal peptide probabilty 0.611) with cleavage site probability 0.269 between residues 21 and 22; signal peptide 282459001439 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 282459001440 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 282459001441 Pfam match to entry PF01773 Nucleoside_tra2, Na+ dependent nucleoside transporter, score 427.9, E-value 9.7e-126 282459001442 8 probable transmembrane helices predicted for SAS0290 by TMHMM2.0 at aa 4-22, 34-56, 88-110, 192-211, 264-286, 293-315, 347-369 and 382-404 282459001443 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 282459001444 putative transporter; Provisional; Region: PRK10484 282459001445 Na binding site [ion binding]; other site 282459001446 13 probable transmembrane helices predicted for SAS0291 by TMHMM2.0 at aa 4-26, 46-68, 78-100, 121-143, 158-180, 187-205, 232-254, 275-297, 317-339, 373-395, 405-427, 432-449 and 459-481 282459001447 Pfam match to entry PF00474 SSF, Sodium:solute symporter family, score 39.1, E-value 1.9e-10 282459001448 N-acetylneuraminate lyase; Provisional; Region: PRK04147 282459001449 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 282459001450 inhibitor site; inhibition site 282459001451 active site 282459001452 dimer interface [polypeptide binding]; other site 282459001453 catalytic residue [active] 282459001454 Pfam match to entry PF00701 DHDPS, Dihydrodipicolinate synthetase family, score 306.4, E-value 3.5e-89 282459001455 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 282459001456 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 282459001457 nucleotide binding site [chemical binding]; other site 282459001458 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 282459001459 Pfam match to entry PF00480 ROK, ROK family, score 32.8, E-value 3.7e-09 282459001460 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 282459001461 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 282459001462 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 282459001463 putative active site [active] 282459001464 Pfam match to entry PF01380 SIS, SIS domain, score 67.2, E-value 3.8e-17 282459001465 Pfam match to entry PF01418 HTH_6, Helix-turn-helix domain, rpiR family, score 24.4, E-value 4.7e-07 282459001466 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 282459001467 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 282459001468 putative active site cavity [active] 282459001469 Pfam match to entry PF04131 nanE, N-acetylmannosamine-6-phosphate epimerase, score 284.9, E-value 1.1e-82 282459001470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 282459001471 Nucleoside recognition; Region: Gate; pfam07670 282459001472 12 probable transmembrane helices predicted for SAS0296 by TMHMM2.0 at aa 12-31, 51-73, 80-102, 124-146, 167-186, 201-223, 230-252, 304-326, 331-348, 352-374, 381-403 and 413-435 282459001473 Signal peptide predicted for SAS0297 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.935 between residues 37 and 38; signal peptide 282459001474 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 282459001475 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 282459001476 PGAP1-like protein; Region: PGAP1; pfam07819 282459001477 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 47.5, E-value 3.2e-11 282459001478 PS00017 ATP/GTP-binding site motif A (P-loop). 282459001479 PS00120 Lipases, serine active site. 282459001480 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 282459001481 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 282459001482 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 282459001483 putative active site [active] 282459001484 putative FMN binding site [chemical binding]; other site 282459001485 putative substrate binding site [chemical binding]; other site 282459001486 putative catalytic residue [active] 282459001487 Pfam match to entry PF00724 oxidored_FMN, NADH:flavin oxidoreductase / NADH oxidase family, score 175.0, E-value 1.3e-49 282459001488 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 282459001489 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 282459001490 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 282459001491 Pfam match to entry PF00296 bac_luciferase, Luciferase-like monooxygenase, score 57.0, E-value 4.4e-14 282459001492 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 282459001493 lipoyl attachment site [posttranslational modification]; other site 282459001494 Pfam match to entry PF01597 GCV_H, Glycine cleavage H-protein, score -12.4, E-value 2.8e-07 282459001495 Replication protein C N-terminal domain; Region: RP-C; pfam03428 282459001496 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 282459001497 putative ADP-ribose binding site [chemical binding]; other site 282459001498 Pfam match to entry PF01661 A1pp, Appr-1 -p processing enzyme family, score 112.3, E-value 9.5e-31 282459001499 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 282459001500 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 282459001501 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 282459001502 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 282459001503 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 282459001504 Pfam match to entry PF03099 BPL_LipA_LipB, Biotin/lipoate A/B protein ligase family, score 77.4, E-value 3.1e-20 282459001505 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 282459001506 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 282459001507 NADP binding site [chemical binding]; other site 282459001508 putative substrate binding site [chemical binding]; other site 282459001509 active site 282459001510 PS00152 ATP synthase alpha and beta subunits signature. 282459001511 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 282459001512 10 probable transmembrane helices predicted for SAS0306 by TMHMM2.0 at aa 7-29, 93-112, 119-141, 145-167, 224-246, 261-283, 315-337, 341-363, 370-392 and 407-440 282459001513 Pfam match to entry PF04215 SgaT_UlaA, sugar-specific permease, SgaT/UlaA, score 397.1, E-value 1.8e-116 282459001514 PS00017 ATP/GTP-binding site motif A (P-loop). 282459001515 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 282459001516 active site 282459001517 P-loop; other site 282459001518 phosphorylation site [posttranslational modification] 282459001519 Pfam match to entry PF02302 PTS_IIB, PTS system, Lactose/Cellobiose specific IIB subunit, score 102.7, E-value 7.4e-28 282459001520 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282459001521 active site 282459001522 phosphorylation site [posttranslational modification] 282459001523 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 99.1, E-value 8.9e-27 282459001524 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 282459001525 HTH domain; Region: HTH_11; pfam08279 282459001526 HTH domain; Region: HTH_11; pfam08279 282459001527 PRD domain; Region: PRD; pfam00874 282459001528 PRD domain; Region: PRD; pfam00874 282459001529 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 282459001530 active site 282459001531 P-loop; other site 282459001532 phosphorylation site [posttranslational modification] 282459001533 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282459001534 active site 282459001535 phosphorylation site [posttranslational modification] 282459001536 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 17.5, E-value 3.7e-07 282459001537 Pfam match to entry PF02302 PTS_IIB, PTS system, Lactose/Cellobiose specific IIB subunit, score 20.8, E-value 3e-05 282459001538 Pfam match to entry PF00874 PRD, PRD domain, score 108.1, E-value 1.7e-29 282459001539 Pfam match to entry PF00874 PRD, PRD domain, score 85.4, E-value 1.2e-22 282459001540 Predicted helix-turn-helix motif for SAS0309 with score 1440.000, SD 4.09 at aa 105-126, sequence VSTKQLAQDVNVSRRTIADDIK 282459001541 Predicted helix-turn-helix motif for SAS0309 with score 1474.000, SD 4.21 at aa 20-41, sequence IPINTIANQLGVSPRTIQYDIA 282459001542 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 282459001543 MarR family; Region: MarR_2; pfam12802 282459001544 Pfam match to entry PF01047 MarR, MarR family, score 58.5, E-value 1.6e-14 282459001545 Predicted helix-turn-helix motif for SAS0310 with score 1531.000, SD 4.40 at aa 48-69, sequence LTQNDIAKALQRTGPTVSNLLR 282459001546 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 282459001547 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 282459001548 12 probable transmembrane helices predicted for SAS0311 by TMHMM2.0 at aa 20-42, 52-74, 95-117, 132-154, 167-189, 194-216, 243-265, 285-307, 319-338, 353-375, 388-410 and 415-437 282459001549 Pfam match to entry PF01554 MatE, MatE, score 95.3, E-value 1.3e-25 282459001550 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 282459001551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 282459001552 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 282459001553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459001554 putative substrate translocation pore; other site 282459001555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459001556 12 probable transmembrane helices predicted for SAS0313 by TMHMM2.0 at aa 27-44, 64-86, 93-115, 119-138, 159-181, 196-215, 261-280, 300-319, 331-348, 358-380, 393-415 and 420-442 282459001557 PS00942 glpT family of transporters signature. 282459001558 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 282459001559 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 282459001560 Zn binding site [ion binding]; other site 282459001561 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 282459001562 Zn binding site [ion binding]; other site 282459001563 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 52.3, E-value 1.1e-12 282459001564 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 17.6, E-value 6.6e-05 282459001565 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 282459001566 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 282459001567 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 282459001568 Pfam match to entry PF00296 bac_luciferase, Luciferase-like monooxygenase, score 76.0, E-value 8e-20 282459001569 Predicted flavoprotein [General function prediction only]; Region: COG0431 282459001570 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 282459001571 Pfam match to entry PF03358 FMN_red, NADPH-dependent FMN reductase, score 28.9, E-value 9.3e-09 282459001572 Predicted membrane protein [Function unknown]; Region: COG2855 282459001573 Signal peptide predicted for SAS0317 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.527 between residues 37 and 38; signal peptide 282459001574 11 probable transmembrane helices predicted for SAS0317 by TMHMM2.0 at aa 9-26, 31-48, 69-88, 93-115, 122-144, 154-176, 183-202, 217-234, 247-269, 273-295 and 308-330 282459001575 Pfam match to entry PF03601 Cons_hypoth698, Conserved hypothetical protein 698, score 487.6, E-value 1e-143 282459001576 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282459001577 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 282459001578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 282459001579 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 55.6, E-value 1.1e-13 282459001580 Signal peptide predicted for SAS0319 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.666 between residues 25 and 26; signal peptide 282459001581 Imelysin; Region: Peptidase_M75; pfam09375 282459001582 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459001583 Pfam match to entry PF04302 DUF451, Protein of unknown function (DUF451), score 603.1, E-value 1.8e-178 282459001584 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 282459001585 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 282459001586 1 probable transmembrane helix predicted for SAS0320 by TMHMM2.0 at aa 21-40 282459001587 Pfam match to entry PF04261 Dyp_perox, Dyp-type peroxidase family, score 610.8, E-value 8.5e-181 282459001588 Signal peptide predicted for SAS0321 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.689 between residues 29 and 30; signal peptide 282459001589 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 282459001590 7 probable transmembrane helices predicted for SAS0321 by TMHMM2.0 at aa 5-25, 356-378, 393-410, 431-450, 470-492, 499-521 and 552-569 282459001591 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 282459001592 6 probable transmembrane helices predicted for SAS0322 by TMHMM2.0 at aa 12-34, 58-80, 100-122, 150-172, 184-201 and 205-222 282459001593 Pfam match to entry PF00902 TatC, Sec-independent protein translocase (TatC), score 236.5, E-value 4e-68 282459001594 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 282459001595 Pfam match to entry PF02416 MttA_Hcf106, mttA/Hcf106 family, score 71.8, E-value 1.5e-18 282459001596 1 probable transmembrane helix predicted for SAS0323 by TMHMM2.0 at aa 5-27 282459001597 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 282459001598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282459001599 non-specific DNA binding site [nucleotide binding]; other site 282459001600 salt bridge; other site 282459001601 sequence-specific DNA binding site [nucleotide binding]; other site 282459001602 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 56.3, E-value 6.8e-14 282459001603 Predicted helix-turn-helix motif for SAS0325 with score 2277.000, SD 6.94 at aa 14-35, sequence LNQTQLAKLAGVSRQTISLIER 282459001604 Predicted helix-turn-helix motif for SAS0325 with score 1224.000, SD 3.36 at aa 43-64, sequence LTAIKIARIFNETVETVFIIEE 282459001605 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 282459001606 6 probable transmembrane helices predicted for SAS0326 by TMHMM2.0 at aa 7-25, 40-62, 95-117, 127-146, 185-207 and 212-231 282459001607 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 282459001608 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 282459001609 Walker A/P-loop; other site 282459001610 ATP binding site [chemical binding]; other site 282459001611 Q-loop/lid; other site 282459001612 ABC transporter signature motif; other site 282459001613 Walker B; other site 282459001614 D-loop; other site 282459001615 H-loop/switch region; other site 282459001616 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 140.7, E-value 2.7e-39 282459001617 PS00017 ATP/GTP-binding site motif A (P-loop). 282459001618 Signal peptide predicted for SAS0328 by SignalP 2.0 HMM (Signal peptide probabilty 0.813) with cleavage site probability 0.764 between residues 40 and 41; signal peptide 282459001619 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 282459001620 5 probable transmembrane helices predicted for SAS0328 by TMHMM2.0 at aa 15-37, 80-102, 107-129, 141-163 and 178-200 282459001621 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00014 Endoplasmic reticulum targeting sequence. 282459001622 Predicted membrane protein [Function unknown]; Region: COG4292 282459001623 11 probable transmembrane helices predicted for SAS0329 by TMHMM2.0 at aa 15-37, 49-68, 83-100, 107-129, 144-161, 168-190, 205-222, 227-249, 264-286, 293-315 and 350-367 282459001624 putative acyltransferase; Provisional; Region: PRK05790 282459001625 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 282459001626 dimer interface [polypeptide binding]; other site 282459001627 active site 282459001628 Pfam match to entry PF00108 thiolase, Thiolase, N-terminal domain, score 542.1, E-value 4.2e-160 282459001629 PS00098 Thiolases acyl-enzyme intermediate signature. 282459001630 Pfam match to entry PF02803 thiolase_C, Thiolase, C-terminal domain, score 225.0, E-value 1.1e-64 282459001631 PS00737 Thiolases signature 2. 282459001632 PS00099 Thiolases active site. 282459001633 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 282459001634 Pfam match to entry PF04199 Cyclase, cyclase, score 294.1, E-value 1.8e-85 282459001635 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 282459001636 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 282459001637 THF binding site; other site 282459001638 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 282459001639 substrate binding site [chemical binding]; other site 282459001640 THF binding site; other site 282459001641 zinc-binding site [ion binding]; other site 282459001642 Pfam match to entry PF01717 Methionine_synt, Methionine synthase, vitamin-B12 independent, score 603.7, E-value 1.2e-178 282459001643 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 282459001644 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 282459001645 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 282459001646 FAD binding site [chemical binding]; other site 282459001647 Pfam match to entry PF02219 MTHFR, Methylenetetrahydrofolate reductase, score -46.5, E-value 9.1e-11 282459001648 Pfam match to entry PF02574 S-methyl_trans, Homocysteine S-methyltransferase, score 200.4, E-value 2.9e-57 282459001649 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 282459001650 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 282459001651 homodimer interface [polypeptide binding]; other site 282459001652 substrate-cofactor binding pocket; other site 282459001653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459001654 catalytic residue [active] 282459001655 Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme, score 545.8, E-value 3e-161 282459001656 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 282459001657 cystathionine gamma-synthase; Reviewed; Region: PRK08247 282459001658 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 282459001659 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282459001660 catalytic residue [active] 282459001661 Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme, score 476.6, E-value 2.1e-140 282459001662 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 282459001663 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 282459001664 ParB-like nuclease domain; Region: ParB; smart00470 282459001665 Pfam match to entry PF02195 ParBc, ParB-like nuclease domain, score 130.5, E-value 3.1e-36 282459001666 Predicted helix-turn-helix motif for SAS0336 with score 1788.000, SD 5.28 at aa 133-154, sequence ITQQEVAKRLSKSRPYIANMLR 282459001667 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 282459001668 Mechanosensitive ion channel; Region: MS_channel; pfam00924 282459001669 3 probable transmembrane helices predicted for SAS0337 by TMHMM2.0 at aa 24-46, 69-91 and 101-120 282459001670 Pfam match to entry PF00924 MS_channel, Mechanosensitive ion channel, score 165.7, E-value 7.9e-47 282459001671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 282459001672 Pfam match to entry PF06107 DUF951, Bacterial protein of unknown function (DUF951), score 143.9, E-value 2.9e-40 282459001673 GTP-binding protein YchF; Reviewed; Region: PRK09601 282459001674 YchF GTPase; Region: YchF; cd01900 282459001675 G1 box; other site 282459001676 GTP/Mg2+ binding site [chemical binding]; other site 282459001677 Switch I region; other site 282459001678 G2 box; other site 282459001679 Switch II region; other site 282459001680 G3 box; other site 282459001681 G4 box; other site 282459001682 G5 box; other site 282459001683 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 282459001684 Pfam match to entry PF01018 GTP1_OBG, GTP1/OBG family, score 21.0, E-value 1.9e-05 282459001685 PS00017 ATP/GTP-binding site motif A (P-loop). 282459001686 Pfam match to entry PF06071 DUF933, Protein of unknown function (DUF933), score 568.2, E-value 5.5e-168 282459001687 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 282459001688 Pfam match to entry PF01250 Ribosomal_S6, Ribosomal protein S6, score 131.7, E-value 1.4e-36 282459001689 PS01048 Ribosomal protein S6 signature. 282459001690 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 282459001691 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 282459001692 dimer interface [polypeptide binding]; other site 282459001693 ssDNA binding site [nucleotide binding]; other site 282459001694 tetramer (dimer of dimers) interface [polypeptide binding]; other site 282459001695 Pfam match to entry PF00436 SSB, Single-strand binding protein family, score 140.7, E-value 2.7e-39 282459001696 PS00735 Single-strand binding protein family signature 1. 282459001697 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 282459001698 Pfam match to entry PF01084 Ribosomal_S18, Ribosomal protein S18, score 125.8, E-value 8.6e-35 282459001699 PS00057 Ribosomal protein S18 signature. 282459001700 Abi-like protein; Region: Abi_2; pfam07751 282459001701 Probable gene remnant. Similar to internal regions of bacteriophage L54a integrase Int SWALL:VINT_BPL54 (SWALL:P20709) (354 aa) fasta scores: E(): 0.00091, 34.56% id in 81 aa, and Lactococcus lactis prophage PS2 probable integrase ll0503 SWALL:P2IN_LACLA (SWALL:Q9CI63) (382 aa) fasta scores: E(): 0.025, 31.16% id in 77 aa; integrase (fragment) 282459001702 Signal peptide predicted for SAS0347 by SignalP 2.0 HMM (Signal peptide probabilty 0.948) with cleavage site probability 0.882 between residues 35 and 36; signal peptide 282459001703 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459001704 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -22.7, E-value 0.076 282459001705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 282459001706 Signal peptide predicted for SAS0348 by SignalP 2.0 HMM (Signal peptide probabilty 0.738) with cleavage site probability 0.547 between residues 32 and 33; signal peptide 282459001707 1 probable transmembrane helix predicted for SAS0348 by TMHMM2.0 at aa 7-24 282459001708 Signal peptide predicted for SAS0349 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.578 between residues 20 and 21; signal peptide 282459001709 Predicted membrane protein [Function unknown]; Region: COG3212 282459001710 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 282459001711 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459001712 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 282459001713 non-specific DNA binding site [nucleotide binding]; other site 282459001714 salt bridge; other site 282459001715 sequence-specific DNA binding site [nucleotide binding]; other site 282459001716 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 282459001717 3 probable transmembrane helices predicted for SAS0351 by TMHMM2.0 at aa 4-23, 30-52 and 56-78 282459001718 Pfam match to entry PF04226 Transgly_assoc, Transglycosylase associated protein, score 68.2, E-value 1.8e-17 282459001719 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 282459001720 catalytic core [active] 282459001721 Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family, score 79.2, E-value 8.6e-21 282459001722 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 282459001723 Signal peptide predicted for SAS0354 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.379 between residues 35 and 36; signal peptide 282459001724 4 probable transmembrane helices predicted for SAS0354 by TMHMM2.0 at aa 5-23, 38-60, 67-89 and 94-116 282459001725 Signal peptide predicted for SAS0355 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.678 between residues 21 and 22; signal peptide 282459001726 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 282459001727 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459001728 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 282459001729 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 282459001730 catalytic residue [active] 282459001731 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 282459001732 catalytic residues [active] 282459001733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 282459001734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282459001735 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 236.2, E-value 4.9e-68 282459001736 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 282459001737 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 282459001738 peroxiredoxin; Region: AhpC; TIGR03137 282459001739 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 282459001740 dimer interface [polypeptide binding]; other site 282459001741 decamer (pentamer of dimers) interface [polypeptide binding]; other site 282459001742 catalytic triad [active] 282459001743 peroxidatic and resolving cysteines [active] 282459001744 Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family, score 217.3, E-value 2.4e-62 282459001745 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 282459001746 dimer interface [polypeptide binding]; other site 282459001747 FMN binding site [chemical binding]; other site 282459001748 NADPH bind site [chemical binding]; other site 282459001749 Pfam match to entry PF00881 Nitroreductase, Nitroreductase family, score 106.4, E-value 5.9e-29 282459001750 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 282459001751 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 282459001752 Pfam match to entry PF00375 SDF, Sodium:dicarboxylate symporter family, score 284.3, E-value 1.6e-82 282459001753 9 probable transmembrane helices predicted for SAS0360 by TMHMM2.0 at aa 4-21, 34-53, 68-90, 109-131, 180-202, 222-244, 264-286, 368-390 and 394-416 282459001754 Predicted helix-turn-helix motif for SAS0361 with score 1266.000, SD 3.50 at aa 1-22, sequence MLTKEFAQRVELSEKQVRKIVQ 282459001755 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282459001756 active site 282459001757 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 55.4, E-value 1.3e-13 282459001758 xanthine permease; Region: pbuX; TIGR03173 282459001759 Pfam match to entry PF00860 xan_ur_permease, Permease family, score 426.0, E-value 3.6e-125 282459001760 13 probable transmembrane helices predicted for SAS0365 by TMHMM2.0 at aa 10-29, 36-55, 59-81, 88-107, 117-139, 152-171, 176-195, 215-237, 268-290, 303-325, 329-351, 358-380 and 390-412 282459001761 PS01116 Xanthine/uracil permeases family signature. 282459001762 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 282459001763 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 282459001764 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 282459001765 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 282459001766 active site 282459001767 Pfam match to entry PF00478 IMPDH, IMP dehydrogenase / GMP reductase domain, score 708.3, E-value 3.8e-210 282459001768 Pfam match to entry PF00571 CBS, CBS domain, score 52.0, E-value 1.4e-12 282459001769 Pfam match to entry PF00571 CBS, CBS domain, score 54.3, E-value 2.8e-13 282459001770 PS00487 IMP dehydrogenase / GMP reductase signature. 282459001771 GMP synthase; Reviewed; Region: guaA; PRK00074 282459001772 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 282459001773 AMP/PPi binding site [chemical binding]; other site 282459001774 candidate oxyanion hole; other site 282459001775 catalytic triad [active] 282459001776 potential glutamine specificity residues [chemical binding]; other site 282459001777 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 282459001778 ATP Binding subdomain [chemical binding]; other site 282459001779 Ligand Binding sites [chemical binding]; other site 282459001780 Dimerization subdomain; other site 282459001781 Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I, score 212.5, E-value 6.6e-61 282459001782 Pfam match to entry PF03054 tRNA_Me_trans, tRNA methyl transferase, score 37.3, E-value 6.9e-12 282459001783 Pfam match to entry PF00958 GMP_synt_C, GMP synthase C terminal domain, score 231.9, E-value 9.3e-67 282459001784 Abi-like protein; Region: Abi_2; pfam07751 282459001785 2 probable transmembrane helices predicted for SAS0369 by TMHMM2.0 at aa 13-35 and 40-59 282459001786 Signal peptide predicted for SAS0371 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.563 between residues 28 and 29; signal peptide 282459001787 2 probable transmembrane helices predicted for SAS0372 by TMHMM2.0 at aa 21-43 and 58-80 282459001788 2 probable transmembrane helices predicted for SAS0373 by TMHMM2.0 at aa 54-76 and 81-103 282459001789 Protein of unknown function DUF262; Region: DUF262; pfam03235 282459001790 Pfam match to entry PF03235 DUF262, Protein of unknown function DUF262, score -27.9, E-value 0.0037 282459001791 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 282459001792 Protein of unknown function (DUF523); Region: DUF523; pfam04463 282459001793 Pfam match to entry PF04463 DUF523, Protein of unknown function (DUF523), score 203.5, E-value 3.3e-58 282459001794 LabA_like proteins; Region: LabA_like; cd06167 282459001795 putative metal binding site [ion binding]; other site 282459001796 Uncharacterized conserved protein [Function unknown]; Region: COG1432 282459001797 Predicted membrane protein [Function unknown]; Region: COG3759 282459001798 3 probable transmembrane helices predicted for SAS0382 by TMHMM2.0 at aa 4-22, 50-72 and 82-104 282459001799 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 282459001800 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 282459001801 NADP binding site [chemical binding]; other site 282459001802 superantigen-like protein; Reviewed; Region: PRK13037 282459001803 Signal peptide predicted for SAS0384 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.978 between residues 30 and 31; signal peptide 282459001804 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282459001805 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459001806 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -8.3, E-value 0.0056 282459001807 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459001808 superantigen-like protein; Reviewed; Region: PRK13041 282459001809 Signal peptide predicted for SAS0385 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 30 and 31; signal peptide 282459001810 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282459001811 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459001812 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -29.4, E-value 0.26 282459001813 superantigen-like protein; Reviewed; Region: PRK13335 282459001814 Signal peptide predicted for SAS0386 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.881 between residues 30 and 31; signal peptide 282459001815 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282459001816 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459001817 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -4.3, E-value 0.0027 282459001818 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459001819 superantigen-like protein; Reviewed; Region: PRK13042 282459001820 Signal peptide predicted for SAS0387 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.592 between residues 30 and 31; signal peptide 282459001821 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282459001822 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459001823 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -0.3, E-value 0.0013 282459001824 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459001825 superantigen-like protein 5; Reviewed; Region: PRK13035 282459001826 Signal peptide predicted for SAS0388 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.985 between residues 30 and 31; signal peptide 282459001827 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282459001828 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459001829 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -31.0, E-value 0.34 282459001830 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459001831 Signal peptide predicted for SAS0389 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 30 and 31; signal peptide 282459001832 superantigen-like protein; Reviewed; Region: PRK13040 282459001833 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282459001834 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459001835 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -17.3, E-value 0.029 282459001836 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459001837 Signal peptide predicted for SAS0390 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.939 between residues 30 and 31; signal peptide 282459001838 superantigen-like protein 7; Reviewed; Region: PRK13346 282459001839 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282459001840 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459001841 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 5.6, E-value 0.00044 282459001842 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459001843 superantigen-like protein; Reviewed; Region: PRK13039 282459001844 Signal peptide predicted for SAS0391 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.914 between residues 32 and 33; signal peptide 282459001845 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282459001846 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459001847 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 25.4, E-value 1.2e-05 282459001848 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459001849 Signal peptide predicted for SAS0392 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.600 between residues 27 and 28; signal peptide 282459001850 superantigen-like protein; Reviewed; Region: PRK13345 282459001851 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282459001852 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459001853 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 12.1, E-value 0.00014 282459001854 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459001855 Signal peptide predicted for SAS0393 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.575 between residues 27 and 28; signal peptide 282459001856 superantigen-like protein 5; Reviewed; Region: PRK13035 282459001857 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282459001858 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459001859 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -1.6, E-value 0.0016 282459001860 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459001861 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 282459001862 HsdM N-terminal domain; Region: HsdM_N; pfam12161 282459001863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459001864 S-adenosylmethionine binding site [chemical binding]; other site 282459001865 Pfam match to entry PF02506 Methylase_M, Type I restriction modification system, M protein, score 271.1, E-value 1.6e-78 282459001866 PS00092 N-6 Adenine-specific DNA methylases signature. 282459001867 Pfam match to entry PF02384 N6_Mtase, N-6 DNA Methylase, score 254.9, E-value 1.1e-73 282459001868 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 282459001869 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 282459001870 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 282459001871 Pfam match to entry PF01420 Methylase_S, Type I restriction modification DNA specificity domain, score 82.9, E-value 6.9e-22 282459001872 Pfam match to entry PF01420 Methylase_S, Type I restriction modification DNA specificity domain, score 68.4, E-value 1.6e-17 282459001873 superantigen-like protein; Reviewed; Region: PRK13036 282459001874 Signal peptide predicted for SAS0396 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 30 and 31; signal peptide 282459001875 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 282459001876 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459001877 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -3.7, E-value 0.0024 282459001878 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459001879 Signal peptide predicted for SAS0397 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.856 between residues 32 and 33; signal peptide 282459001880 Signal peptide predicted for SAS0398 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.788 between residues 29 and 30; signal peptide 282459001881 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282459001882 Pfam match to entry PF04507 DUF576, Protein of unknown function, DUF576, score 552.7, E-value 2.5e-163 282459001883 1 probable transmembrane helix predicted for SAS0399 by TMHMM2.0 at aa 12-34 282459001884 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459001885 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282459001886 Signal peptide predicted for SAS0400 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.865 between residues 31 and 32; signal peptide 282459001887 Pfam match to entry PF04507 DUF576, Protein of unknown function, DUF576, score 578.8, E-value 3.5e-171 282459001888 1 probable transmembrane helix predicted for SAS0400 by TMHMM2.0 at aa 7-29 282459001889 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459001890 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282459001891 Signal peptide predicted for SAS0401 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.487 between residues 27 and 28; signal peptide 282459001892 Pfam match to entry PF04507 DUF576, Protein of unknown function, DUF576, score 598.9, E-value 3.3e-177 282459001893 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459001894 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282459001895 Signal peptide predicted for SAS0402 by SignalP 2.0 HMM (Signal peptide probabilty 0.758) with cleavage site probability 0.372 between residues 26 and 27; signal peptide 282459001896 Pfam match to entry PF04507 DUF576, Protein of unknown function, DUF576, score 617.6, E-value 7.5e-183 282459001897 1 probable transmembrane helix predicted for SAS0402 by TMHMM2.0 at aa 7-24 282459001898 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459001899 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282459001900 Pfam match to entry PF04507 DUF576, Protein of unknown function, DUF576, score 604.2, E-value 8.4e-179 282459001901 1 probable transmembrane helix predicted for SAS0403 by TMHMM2.0 at aa 7-24 282459001902 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459001903 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 282459001904 Signal peptide predicted for SAS0407 by SignalP 2.0 HMM (Signal peptide probabilty 0.835) with cleavage site probability 0.293 between residues 28 and 29; signal peptide 282459001905 2 probable transmembrane helices predicted for SAS0407 by TMHMM2.0 at aa 4-21 and 34-56 282459001906 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 282459001907 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 282459001908 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 282459001909 Pfam match to entry PF02492 cobW, Cobalamin synthesis protein/P47K, score 644.3, E-value 6.8e-191 282459001910 PS00017 ATP/GTP-binding site motif A (P-loop). 282459001911 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 282459001912 Signal peptide predicted for SAS0410 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.396 between residues 26 and 27; signal peptide 282459001913 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 282459001914 14 probable transmembrane helices predicted for SAS0410 by TMHMM2.0 at aa 7-29, 34-56, 69-86, 101-118, 125-142, 157-179, 191-213, 228-247, 254-276, 291-313, 343-365, 369-386, 398-420 and 435-457 282459001915 Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 157.9, E-value 1.9e-44 282459001916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 282459001917 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 282459001918 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 282459001919 4 probable transmembrane helices predicted for SAS0413 by TMHMM2.0 at aa 10-29, 36-54, 64-83 and 88-110 282459001920 Signal peptide predicted for SAS0414 by SignalP 2.0 HMM (Signal peptide probabilty 0.887) with cleavage site probability 0.558 between residues 29 and 30; signal peptide 282459001921 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 282459001922 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 282459001923 active site 282459001924 6 probable transmembrane helices predicted for SAS0414 by TMHMM2.0 at aa 13-32, 74-93, 98-116, 144-161, 168-190 and 195-217 282459001925 Pfam match to entry PF01569 PAP2, PAP2 superfamily, score 67.7, E-value 2.6e-17 282459001926 Esterase/lipase [General function prediction only]; Region: COG1647 282459001927 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 282459001928 Signal peptide predicted for SAS0416 by SignalP 2.0 HMM (Signal peptide probabilty 0.730) with cleavage site probability 0.246 between residues 23 and 24; signal peptide 282459001929 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 282459001930 Na2 binding site [ion binding]; other site 282459001931 putative substrate binding site 1 [chemical binding]; other site 282459001932 Na binding site 1 [ion binding]; other site 282459001933 putative substrate binding site 2 [chemical binding]; other site 282459001934 Pfam match to entry PF00209 SNF, Sodium:neurotransmitter symporter family, score -98.9, E-value 9.6e-14 282459001935 11 probable transmembrane helices predicted for SAS0416 by TMHMM2.0 at aa 13-30, 45-67, 94-116, 144-166, 179-198, 218-240, 253-275, 303-325, 344-366, 381-403 and 423-445 282459001936 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 282459001937 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 282459001938 dimer interface [polypeptide binding]; other site 282459001939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459001940 catalytic residue [active] 282459001941 Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme, score 296.6, E-value 3.2e-86 282459001942 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 282459001943 cystathionine beta-lyase; Provisional; Region: PRK07671 282459001944 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 282459001945 homodimer interface [polypeptide binding]; other site 282459001946 substrate-cofactor binding pocket; other site 282459001947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459001948 catalytic residue [active] 282459001949 Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme, score 671.8, E-value 3.7e-199 282459001950 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 282459001951 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 282459001952 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 282459001953 Walker A/P-loop; other site 282459001954 ATP binding site [chemical binding]; other site 282459001955 Q-loop/lid; other site 282459001956 ABC transporter signature motif; other site 282459001957 Walker B; other site 282459001958 D-loop; other site 282459001959 H-loop/switch region; other site 282459001960 NIL domain; Region: NIL; pfam09383 282459001961 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 224.7, E-value 1.4e-64 282459001962 PS00017 ATP/GTP-binding site motif A (P-loop). 282459001963 PS00211 ABC transporters family signature. 282459001964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459001965 dimer interface [polypeptide binding]; other site 282459001966 conserved gate region; other site 282459001967 ABC-ATPase subunit interface; other site 282459001968 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 62.8, E-value 7.8e-16 282459001969 5 probable transmembrane helices predicted for SAS0420 by TMHMM2.0 at aa 20-42, 62-79, 83-105, 148-170 and 190-212 282459001970 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282459001971 Signal peptide predicted for SAS0421 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.271 between residues 25 and 26; signal peptide 282459001972 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 282459001973 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 282459001974 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459001975 Pfam match to entry PF03180 Lipoprotein_9, NLPA lipoprotein, score 385.8, E-value 4.4e-113 282459001976 Signal peptide predicted for SAS0422 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 25 and 26; signal peptide 282459001977 LysM domain; Region: LysM; pfam01476 282459001978 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282459001979 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282459001980 Surface antigen [General function prediction only]; Region: COG3942 282459001981 CHAP domain; Region: CHAP; pfam05257 282459001982 Pfam match to entry PF01476 LysM, LysM domain, score 69.6, E-value 6.9e-18 282459001983 Pfam match to entry PF01476 LysM, LysM domain, score 71.3, E-value 2.2e-18 282459001984 Pfam match to entry PF01476 LysM, LysM domain, score 71.9, E-value 1.4e-18 282459001985 Pfam match to entry PF05257 CHAP, CHAP domain, score 165.4, E-value 1e-46 282459001986 1 probable transmembrane helix predicted for SAS0423 by TMHMM2.0 at aa 36-55 282459001987 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 282459001988 nudix motif; other site 282459001989 Pfam match to entry PF00293 NUDIX, NUDIX domain, score 44.0, E-value 3.5e-10 282459001990 PS00893 mutT domain signature. 282459001991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459001992 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 282459001993 Coenzyme A binding pocket [chemical binding]; other site 282459001994 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 43.1, E-value 6.4e-10 282459001995 Signal peptide predicted for SAS0426 by SignalP 2.0 HMM (Signal peptide probabilty 0.636) with cleavage site probability 0.234 between residues 23 and 24; signal peptide 282459001996 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 282459001997 7 probable transmembrane helices predicted for SAS0426 by TMHMM2.0 at aa 4-19, 24-46, 50-72, 79-101, 116-138, 180-202 and 222-244 282459001998 Signal peptide predicted for SAS0427 by SignalP 2.0 HMM (Signal peptide probabilty 0.980) with cleavage site probability 0.295 between residues 39 and 40; signal peptide 282459001999 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 282459002000 8 probable transmembrane helices predicted for SAS0427 by TMHMM2.0 at aa 13-32, 127-144, 151-170, 175-197, 204-226, 248-270, 300-322 and 342-364 282459002001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 282459002002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 282459002003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 282459002004 dimerization interface [polypeptide binding]; other site 282459002005 Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 88.4, E-value 1.5e-23 282459002006 PS00044 Bacterial regulatory proteins, lysR family signature. 282459002007 Predicted helix-turn-helix motif for SAS0428 with score 1683.000, SD 4.92 at aa 16-37, sequence EHISETALELNIAQSAISRQIT 282459002008 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 282459002009 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 282459002010 active site 282459002011 dimer interface [polypeptide binding]; other site 282459002012 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 282459002013 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 282459002014 active site 282459002015 FMN binding site [chemical binding]; other site 282459002016 substrate binding site [chemical binding]; other site 282459002017 3Fe-4S cluster binding site [ion binding]; other site 282459002018 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 282459002019 domain interface; other site 282459002020 Pfam match to entry PF04897 Glu_synth_NTN, Glutamate synthase amidotransferase domain, score 881.9, E-value 2e-262 282459002021 Pfam match to entry PF04898 Glu_syn_central, Glutamate synthase central domain, score 528.1, E-value 6.8e-156 282459002022 Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase, score 757.5, E-value 5.6e-225 282459002023 Pfam match to entry PF01493 GXGXG, GXGXG motif, score 219.1, E-value 6.8e-63 282459002024 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 282459002025 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 77.0, E-value 4e-20 282459002026 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 282459002027 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282459002028 active site turn [active] 282459002029 phosphorylation site [posttranslational modification] 282459002030 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282459002031 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 68.2, E-value 1.8e-17 282459002032 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282459002033 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 159.0, E-value 8.6e-45 282459002034 9 probable transmembrane helices predicted for SAS0431 by TMHMM2.0 at aa 113-135, 155-174, 181-203, 266-288, 301-323, 338-360, 373-395, 400-422 and 439-461 282459002035 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 282459002036 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 282459002037 Ca binding site [ion binding]; other site 282459002038 active site 282459002039 catalytic site [active] 282459002040 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 282459002041 Pfam match to entry PF00128 alpha-amylase, Alpha amylase, catalytic domain, score 443.1, E-value 2.5e-130 282459002042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 282459002043 DNA-binding site [nucleotide binding]; DNA binding site 282459002044 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 282459002045 UTRA domain; Region: UTRA; pfam07702 282459002046 Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 57.6, E-value 2.7e-14 282459002047 similar to hypothetical protein; Ortholog of S. aureus MRSA252 (BX571856) SAR0475a; Doubtful CDS. No database matches 282459002048 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 282459002049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459002050 Coenzyme A binding pocket [chemical binding]; other site 282459002051 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 52.6, E-value 8.9e-13 282459002052 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 282459002053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459002054 Walker A motif; other site 282459002055 ATP binding site [chemical binding]; other site 282459002056 Walker B motif; other site 282459002057 arginine finger; other site 282459002058 Pfam match to entry PF00004 AAA, ATPase family associated with various cellular activities (AAA), score 47.8, E-value 2.6e-11 282459002059 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002060 PS00190 Cytochrome c family heme-binding site signature. 282459002061 PS00214 Cytosolic fatty-acid binding proteins signature. 282459002062 hypothetical protein; Validated; Region: PRK00153 282459002063 Pfam match to entry PF02575 DUF149, Uncharacterised BCR, YbaB family COG0718, score 176.6, E-value 4.3e-50 282459002064 recombination protein RecR; Reviewed; Region: recR; PRK00076 282459002065 RecR protein; Region: RecR; pfam02132 282459002066 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 282459002067 putative active site [active] 282459002068 putative metal-binding site [ion binding]; other site 282459002069 tetramer interface [polypeptide binding]; other site 282459002070 Pfam match to entry PF02132 RecR, RecR protein, score 75.4, E-value 1.3e-19 282459002071 PS01300 RecR protein signature. 282459002072 Pfam match to entry PF01751 Toprim, Toprim domain, score 61.8, E-value 1.6e-15 282459002073 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 282459002074 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 282459002075 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282459002076 catalytic residue [active] 282459002077 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 282459002078 Pfam match to entry PF01276 OKR_DC_1, Orn/Lys/Arg decarboxylase, major domain, score 78.3, E-value 1.7e-20 282459002079 Pfam match to entry PF03711 OKR_DC_1_C, Orn/Lys/Arg decarboxylase, C-terminal domain, score 24.3, E-value 1.9e-06 282459002080 thymidylate kinase; Validated; Region: tmk; PRK00698 282459002081 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 282459002082 TMP-binding site; other site 282459002083 ATP-binding site [chemical binding]; other site 282459002084 Pfam match to entry PF02223 Thymidylate_kin, Thymidylate kinase, score 219.6, E-value 4.8e-63 282459002085 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002086 PS01331 Thymidylate kinase signature. 282459002087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 282459002088 Pfam match to entry PF06153 DUF970, Protein of unknown function (DUF970), score 278.1, E-value 1.2e-80 282459002089 DNA polymerase III subunit delta'; Validated; Region: PRK08058 282459002090 DNA polymerase III subunit delta'; Validated; Region: PRK08485 282459002091 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 282459002092 Pfam match to entry PF04468 PSP1, PSP1 C-terminal conserved region, score 180.8, E-value 2.3e-51 282459002093 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 282459002094 Pfam match to entry PF06156 DUF972, Protein of unknown function (DUF972), score 224.5, E-value 1.6e-64 282459002095 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 282459002096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459002097 S-adenosylmethionine binding site [chemical binding]; other site 282459002098 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 282459002099 GIY-YIG motif/motif A; other site 282459002100 putative active site [active] 282459002101 putative metal binding site [ion binding]; other site 282459002102 Pfam match to entry PF01541 Exci_endo_N, Endo/excinuclease amino terminal domain, score 80.2, E-value 4.3e-21 282459002103 Predicted methyltransferases [General function prediction only]; Region: COG0313 282459002104 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 282459002105 putative SAM binding site [chemical binding]; other site 282459002106 putative homodimer interface [polypeptide binding]; other site 282459002107 Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases, score 149.5, E-value 6e-42 282459002108 PS01296 Uncharacterized protein family UPF0011 signature. 282459002109 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 282459002110 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 282459002111 active site 282459002112 HIGH motif; other site 282459002113 KMSKS motif; other site 282459002114 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 282459002115 tRNA binding surface [nucleotide binding]; other site 282459002116 anticodon binding site; other site 282459002117 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 282459002118 dimer interface [polypeptide binding]; other site 282459002119 putative tRNA-binding site [nucleotide binding]; other site 282459002120 Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V), score -106.3, E-value 3.6e-10 282459002121 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282459002122 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002123 Pfam match to entry PF01588 tRNA_bind, tRNA binding domain, score 130.7, E-value 2.9e-36 282459002124 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 282459002125 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 282459002126 active site 282459002127 Pfam match to entry PF01026 TatD_DNase, TatD related DNase, score 394.3, E-value 1.2e-115 282459002128 PS01137 Uncharacterized protein family UPF0006 signature 1. 282459002129 PS01091 Uncharacterized protein family UPF0006 signature 3. 282459002130 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 282459002131 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 282459002132 putative active site [active] 282459002133 putative metal binding site [ion binding]; other site 282459002134 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 282459002135 Pfam match to entry PF01751 Toprim, Toprim domain, score 30.5, E-value 4.2e-06 282459002136 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 282459002137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459002138 S-adenosylmethionine binding site [chemical binding]; other site 282459002139 Pfam match to entry PF00398 RrnaAD, Ribosomal RNA adenine dimethylase, score 289.0, E-value 6.2e-84 282459002140 PS01131 Ribosomal RNA adenine dimethylases signature. 282459002141 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 282459002142 Pfam match to entry PF06257 DUF1021, Protein of unknown function (DUF1021), score 169.2, E-value 7.2e-48 282459002143 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 282459002144 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 282459002145 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 282459002146 Pfam match to entry PF00288 GHMP_kinases, GHMP kinases ATP-binding protein, score 137.8, E-value 2.1e-38 282459002147 pur operon repressor; Provisional; Region: PRK09213 282459002148 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 282459002149 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282459002150 active site 282459002151 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 88.7, E-value 1.2e-23 282459002152 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 282459002153 homotrimer interaction site [polypeptide binding]; other site 282459002154 putative active site [active] 282459002155 Pfam match to entry PF01042 ribonuc_L-PSP, Endoribonuclease L-PSP, score 207.5, E-value 2.1e-59 282459002156 PS01094 Uncharacterized protein family UPF0076 signature. 282459002157 regulatory protein SpoVG; Reviewed; Region: PRK13259 282459002158 Pfam match to entry PF04026 SpoVG, SpoVG, score 228.3, E-value 1.2e-65 282459002159 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 282459002160 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 282459002161 Substrate binding site; other site 282459002162 Mg++ binding site; other site 282459002163 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 282459002164 active site 282459002165 substrate binding site [chemical binding]; other site 282459002166 CoA binding site [chemical binding]; other site 282459002167 Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase, score 33.8, E-value 6.9e-13 282459002168 PS00622 Bacterial regulatory proteins, luxR family signature. 282459002169 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 18.6, E-value 0.015 282459002170 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 14.3, E-value 0.3 282459002171 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 11.6, E-value 1.9 282459002172 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 12.2, E-value 1.3 282459002173 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 4.7, E-value 26 282459002174 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 3.8, E-value 34 282459002175 PS00101 Hexapeptide-repeat containing-transferases signature. 282459002176 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 15.2, E-value 0.17 282459002177 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 282459002178 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 282459002179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282459002180 active site 282459002181 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 282459002182 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 144.5, E-value 1.9e-40 282459002183 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 282459002184 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 282459002185 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 282459002186 5S rRNA interface [nucleotide binding]; other site 282459002187 CTC domain interface [polypeptide binding]; other site 282459002188 L16 interface [polypeptide binding]; other site 282459002189 Pfam match to entry PF01386 Ribosomal_L25p, Ribosomal L25p family, score 110.6, E-value 3.2e-30 282459002190 PS00591 Glycosyl hydrolases family 10 active site. 282459002191 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 282459002192 putative active site [active] 282459002193 catalytic residue [active] 282459002194 Pfam match to entry PF01195 Pept_tRNA_hydro, Peptidyl-tRNA hydrolase, score 279.8, E-value 3.8e-81 282459002195 PS01195 Peptidyl-tRNA hydrolase signature 1. 282459002196 PS01196 Peptidyl-tRNA hydrolase signature 2. 282459002197 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 282459002198 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 282459002199 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282459002200 ATP binding site [chemical binding]; other site 282459002201 putative Mg++ binding site [ion binding]; other site 282459002202 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282459002203 nucleotide binding region [chemical binding]; other site 282459002204 ATP-binding site [chemical binding]; other site 282459002205 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 282459002206 Pfam match to entry PF02559 CarD_TRCF, CarD-like/TRCF domain, score 180.9, E-value 2.2e-51 282459002207 Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase, score 132.1, E-value 1.1e-36 282459002208 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002209 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 80.6, E-value 3.4e-21 282459002210 Pfam match to entry PF03461 TRCF, TRCF domain, score 180.9, E-value 2.2e-51 282459002211 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 282459002212 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 282459002213 Pfam match to entry PF01943 Polysacc_synt, Polysaccharide biosynthesis protein, score 65.8, E-value 9.8e-17 282459002214 14 probable transmembrane helices predicted for SAS0461 by TMHMM2.0 at aa 7-29, 39-61, 82-104, 114-136, 157-174, 179-198, 219-238, 268-290, 311-330, 340-357, 370-392, 397-419, 432-454 and 459-481 282459002215 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 282459002216 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 282459002217 putative SAM binding site [chemical binding]; other site 282459002218 putative homodimer interface [polypeptide binding]; other site 282459002219 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 282459002220 homodimer interface [polypeptide binding]; other site 282459002221 metal binding site [ion binding]; metal-binding site 282459002222 Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases, score 18.5, E-value 2.8e-06 282459002223 Pfam match to entry PF03819 MazG, MazG nucleotide pyrophosphohydrolase domain, score 111.6, E-value 1.6e-30 282459002224 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 282459002225 RNA binding surface [nucleotide binding]; other site 282459002226 Pfam match to entry PF01479 S4, S4 domain, score 37.0, E-value 4.4e-08 282459002227 Signal peptide predicted for SAS0464 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.494 between residues 56 and 57; signal peptide 282459002228 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 282459002229 Septum formation initiator; Region: DivIC; pfam04977 282459002230 Pfam match to entry PF04977 DivIC, Septum formation initiator, score 113.1, E-value 5.6e-31 282459002231 1 probable transmembrane helix predicted for SAS0464 by TMHMM2.0 at aa 34-53 282459002232 hypothetical protein; Provisional; Region: PRK08582 282459002233 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 282459002234 RNA binding site [nucleotide binding]; other site 282459002235 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 91.9, E-value 1.3e-24 282459002236 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 282459002237 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 282459002238 Ligand Binding Site [chemical binding]; other site 282459002239 TilS substrate C-terminal domain; Region: TilS_C; smart00977 282459002240 Pfam match to entry PF01171 ATP_bind3, PP-loop family, score 327.5, E-value 1.6e-95 282459002241 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 282459002242 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282459002243 active site 282459002244 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 104.9, E-value 1.7e-28 282459002245 Signal peptide predicted for SAS0468 by SignalP 2.0 HMM (Signal peptide probabilty 0.753) with cleavage site probability 0.375 between residues 25 and 26; signal peptide 282459002246 FtsH Extracellular; Region: FtsH_ext; pfam06480 282459002247 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 282459002248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459002249 Walker A motif; other site 282459002250 ATP binding site [chemical binding]; other site 282459002251 Walker B motif; other site 282459002252 arginine finger; other site 282459002253 Peptidase family M41; Region: Peptidase_M41; pfam01434 282459002254 2 probable transmembrane helices predicted for SAS0468 by TMHMM2.0 at aa 4-26 and 110-132 282459002255 Pfam match to entry PF00004 AAA, ATPase family associated with various cellular activities (AAA), score 339.0, E-value 5.4e-99 282459002256 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002257 PS00674 AAA-protein family signature. 282459002258 Pfam match to entry PF01434 Peptidase_M41, Peptidase family M41, score 427.4, E-value 1.4e-125 282459002259 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 282459002260 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 282459002261 dimerization interface [polypeptide binding]; other site 282459002262 domain crossover interface; other site 282459002263 redox-dependent activation switch; other site 282459002264 Pfam match to entry PF01430 HSP33, Hsp33 protein, score 579.8, E-value 1.8e-171 282459002265 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 282459002266 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 282459002267 dimer interface [polypeptide binding]; other site 282459002268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459002269 catalytic residue [active] 282459002270 Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme, score 434.5, E-value 9.7e-128 282459002271 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 282459002272 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 282459002273 dihydropteroate synthase; Region: DHPS; TIGR01496 282459002274 substrate binding pocket [chemical binding]; other site 282459002275 dimer interface [polypeptide binding]; other site 282459002276 inhibitor binding site; inhibition site 282459002277 PS00792 Dihydropteroate synthase signature 1. 282459002278 Pfam match to entry PF00809 Pterin_bind, Pterin binding enzyme, score 408.0, E-value 9.5e-120 282459002279 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 282459002280 homooctamer interface [polypeptide binding]; other site 282459002281 active site 282459002282 Pfam match to entry PF02152 FolB, Dihydroneopterin aldolase, score 127.2, E-value 3.2e-35 282459002283 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 282459002284 catalytic center binding site [active] 282459002285 ATP binding site [chemical binding]; other site 282459002286 Pfam match to entry PF01288 HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK), score 202.5, E-value 6.7e-58 282459002287 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 282459002288 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 282459002289 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 282459002290 dimer interface [polypeptide binding]; other site 282459002291 putative anticodon binding site; other site 282459002292 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 282459002293 motif 1; other site 282459002294 active site 282459002295 motif 2; other site 282459002296 motif 3; other site 282459002297 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain, score 77.9, E-value 2.2e-20 282459002298 Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N), score 671.4, E-value 4.7e-199 282459002299 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 282459002300 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282459002301 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 282459002302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 282459002303 DNA-binding site [nucleotide binding]; DNA binding site 282459002304 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 282459002305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459002306 homodimer interface [polypeptide binding]; other site 282459002307 catalytic residue [active] 282459002308 Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 42.7, E-value 8.8e-10 282459002309 Predicted helix-turn-helix motif for SAS0475 with score 1366.000, SD 3.84 at aa 29-50, sequence YSKRQLSKHLSISQTTVEHAYQ 282459002310 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 282459002311 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 282459002312 active site 282459002313 multimer interface [polypeptide binding]; other site 282459002314 Pfam match to entry PF01680 SOR_SNZ, SOR/SNZ family, score 431.9, E-value 6.2e-127 282459002315 Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthase, score 22.4, E-value 2.4e-06 282459002316 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 282459002317 predicted active site [active] 282459002318 catalytic triad [active] 282459002319 Pfam match to entry PF01174 SNO, SNO glutamine amidotransferase family, score 329.7, E-value 3.4e-96 282459002320 PS01236 Uncharacterized protein family UPF0030 signature. 282459002321 Signal peptide predicted for SAS0478 by SignalP 2.0 HMM (Signal peptide probabilty 0.715) with cleavage site probability 0.273 between residues 22 and 23; signal peptide 282459002322 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 282459002323 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 282459002324 Nucleoside recognition; Region: Gate; pfam07670 282459002325 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 282459002326 Pfam match to entry PF01773 Nucleoside_tra2, Na+ dependent nucleoside transporter, score 610.6, E-value 9.9e-181 282459002327 10 probable transmembrane helices predicted for SAS0478 by TMHMM2.0 at aa 4-22, 31-53, 90-109, 114-133, 167-189, 194-216, 251-273, 286-308, 346-368 and 381-403 282459002328 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 282459002329 Pfam match to entry PF05848 CtsR, Firmicute transcriptional repressor of class III stress genes (CtsR), score 362.8, E-value 3.8e-106 282459002330 Predicted helix-turn-helix motif for SAS0479 with score 1132.000, SD 3.04 at aa 26-47, sequence IQRANIAQRFDCVPSQLNYVIK 282459002331 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 282459002332 UvrB/uvrC motif; Region: UVR; pfam02151 282459002333 Pfam match to entry PF02151 UVR, UvrB/uvrC motif, score 26.3, E-value 7.3e-05 282459002334 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 282459002335 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 282459002336 ADP binding site [chemical binding]; other site 282459002337 phosphagen binding site; other site 282459002338 substrate specificity loop; other site 282459002339 Pfam match to entry PF00217 ATP-gua_Ptrans, ATP:guanido phosphotransferase, C-terminal catalytic domain, score 36.3, E-value 6.6e-16 282459002340 PS00112 ATP:guanido phosphotransferases active site. 282459002341 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 282459002342 Clp amino terminal domain; Region: Clp_N; pfam02861 282459002343 Clp amino terminal domain; Region: Clp_N; pfam02861 282459002344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459002345 Walker A motif; other site 282459002346 ATP binding site [chemical binding]; other site 282459002347 Walker B motif; other site 282459002348 arginine finger; other site 282459002349 UvrB/uvrC motif; Region: UVR; pfam02151 282459002350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459002351 Walker A motif; other site 282459002352 ATP binding site [chemical binding]; other site 282459002353 Walker B motif; other site 282459002354 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 282459002355 Pfam match to entry PF02861 Clp_N, Clp amino terminal domain, score 80.6, E-value 3.5e-21 282459002356 Pfam match to entry PF02861 Clp_N, Clp amino terminal domain, score 68.8, E-value 1.2e-17 282459002357 Pfam match to entry PF00004 AAA, ATPase family associated with various cellular activities (AAA), score 53.6, E-value 4.5e-13 282459002358 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002359 PS00870 Chaperonins clpA/B signature 1. 282459002360 Pfam match to entry PF02151 UVR, UvrB/uvrC motif, score 34.8, E-value 2.1e-07 282459002361 Pfam match to entry PF00004 AAA, ATPase family associated with various cellular activities (AAA), score 8.4, E-value 7.6e-05 282459002362 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002363 PS00871 Chaperonins clpA/B signature 2. 282459002364 DNA repair protein RadA; Provisional; Region: PRK11823 282459002365 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 282459002366 Walker A motif/ATP binding site; other site 282459002367 ATP binding site [chemical binding]; other site 282459002368 Walker B motif; other site 282459002369 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 282459002370 Pfam match to entry PF03796 DnaB_C, DnaB-like helicase C terminal domain, score -98.0, E-value 2.6e-05 282459002371 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002372 Signal peptide predicted for SAS0484 by SignalP 2.0 HMM (Signal peptide probabilty 0.781) with cleavage site probability 0.676 between residues 28 and 29; signal peptide 282459002373 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 282459002374 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 282459002375 putative active site [active] 282459002376 4 probable transmembrane helices predicted for SAS0484 by TMHMM2.0 at aa 7-29, 44-61, 82-104 and 114-133 282459002377 Pfam match to entry PF01850 PIN, PIN domain, score 56.0, E-value 8.5e-14 282459002378 Pfam match to entry PF01938 TRAM, TRAM domain, score 15.5, E-value 0.0062 282459002379 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 282459002380 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 282459002381 active site 282459002382 HIGH motif; other site 282459002383 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 282459002384 active site 282459002385 KMSKS motif; other site 282459002386 Pfam match to entry PF00749 tRNA-synt_1c, tRNA synthetases class I (E and Q), catalytic domain, score 640.3, E-value 1.1e-189 282459002387 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282459002388 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 282459002389 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 282459002390 trimer interface [polypeptide binding]; other site 282459002391 active site 282459002392 substrate binding site [chemical binding]; other site 282459002393 CoA binding site [chemical binding]; other site 282459002394 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 6.2, E-value 17 282459002395 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 21.9, E-value 0.0016 282459002396 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 2.7, E-value 46 282459002397 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 9.1, E-value 7.7 282459002398 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 282459002399 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 282459002400 active site 282459002401 HIGH motif; other site 282459002402 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 282459002403 KMSKS motif; other site 282459002404 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 282459002405 tRNA binding surface [nucleotide binding]; other site 282459002406 anticodon binding site; other site 282459002407 Pfam match to entry PF01406 tRNA-synt_1e, tRNA synthetases class I (C), score 723.0, E-value 1.4e-214 282459002408 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 282459002409 active site 282459002410 dimerization interface [polypeptide binding]; other site 282459002411 metal binding site [ion binding]; metal-binding site 282459002412 Pfam match to entry PF05948 DUF880, Protein of unknown function (DUF880), score 269.2, E-value 5.6e-78 282459002413 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 282459002414 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 282459002415 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 282459002416 Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family, score 198.1, E-value 1.5e-56 282459002417 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 282459002418 Pfam match to entry PF05991 DUF901, Protein of unknown function (DUF901), score 320.7, E-value 1.8e-93 282459002419 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 282459002420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 282459002421 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 282459002422 DNA binding residues [nucleotide binding] 282459002423 Pfam match to entry PF04542 sigma70_r2, Sigma-70 region 2, score 49.4, E-value 8.4e-12 282459002424 Predicted helix-turn-helix motif for SAS0491 with score 1274.000, SD 3.53 at aa 155-176, sequence YKPREIAQLMHVKEKVIYNAIQ 282459002425 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 282459002426 Pfam match to entry PF00471 Ribosomal_L33, Ribosomal protein L33, score 49.4, E-value 8.6e-12 282459002427 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 282459002428 Pfam match to entry PF00584 SecE, SecE/Sec61-gamma subunits of protein translocation complex, score 58.6, E-value 1.4e-14 282459002429 PS01067 Protein secE/sec61-gamma signature. 282459002430 1 probable transmembrane helix predicted for SAS0493 by TMHMM2.0 at aa 31-53 282459002431 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 282459002432 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 282459002433 putative homodimer interface [polypeptide binding]; other site 282459002434 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 282459002435 heterodimer interface [polypeptide binding]; other site 282459002436 homodimer interface [polypeptide binding]; other site 282459002437 Pfam match to entry PF02357 NusG, Transcription termination factor nusG, score 94.4, E-value 2.3e-25 282459002438 Pfam match to entry PF00467 KOW, KOW motif, score 44.2, E-value 3e-10 282459002439 PS01014 Transcription termination factor nusG signature. 282459002440 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 282459002441 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 282459002442 23S rRNA interface [nucleotide binding]; other site 282459002443 L7/L12 interface [polypeptide binding]; other site 282459002444 putative thiostrepton binding site; other site 282459002445 L25 interface [polypeptide binding]; other site 282459002446 Pfam match to entry PF03946 Ribosomal_L11_N, Ribosomal protein L11, N-terminal domain, score 134.6, E-value 1.9e-37 282459002447 Pfam match to entry PF00298 Ribosomal_L11, Ribosomal protein L11, RNA binding domain, score 138.7, E-value 1.1e-38 282459002448 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00359 Ribosomal protein L11 signature. 282459002449 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 282459002450 mRNA/rRNA interface [nucleotide binding]; other site 282459002451 Pfam match to entry PF00687 Ribosomal_L1, Ribosomal protein L1p/L10e family, score 434.9, E-value 7.7e-128 282459002452 PS01199 Ribosomal protein L1 signature. 282459002453 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 282459002454 23S rRNA interface [nucleotide binding]; other site 282459002455 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 282459002456 Pfam match to entry PF00466 Ribosomal_L10, Ribosomal protein L10, score 131.1, E-value 2.1e-36 282459002457 PS01109 Ribosomal protein L10 signature. 282459002458 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 282459002459 peripheral dimer interface [polypeptide binding]; other site 282459002460 core dimer interface [polypeptide binding]; other site 282459002461 L10 interface [polypeptide binding]; other site 282459002462 L11 interface [polypeptide binding]; other site 282459002463 putative EF-Tu interaction site [polypeptide binding]; other site 282459002464 putative EF-G interaction site [polypeptide binding]; other site 282459002465 Pfam match to entry PF00542 Ribosomal_L12, Ribosomal protein L7/L12 C-terminal domain, score 135.5, E-value 1e-37 282459002466 Methyltransferase domain; Region: Methyltransf_31; pfam13847 282459002467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459002468 S-adenosylmethionine binding site [chemical binding]; other site 282459002469 Pfam match to entry PF05175 MTS, Methyltransferase small domain, score 90.7, E-value 3.1e-24 282459002470 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 282459002471 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 282459002472 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 282459002473 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 282459002474 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 282459002475 RPB10 interaction site [polypeptide binding]; other site 282459002476 RPB1 interaction site [polypeptide binding]; other site 282459002477 RPB11 interaction site [polypeptide binding]; other site 282459002478 RPB3 interaction site [polypeptide binding]; other site 282459002479 RPB12 interaction site [polypeptide binding]; other site 282459002480 Pfam match to entry PF04563 RNA_pol_Rpb2_1, RNA polymerase beta subunit, score 64.9, E-value 1.7e-16 282459002481 Pfam match to entry PF04561 RNA_pol_Rpb2_2, RNA polymerase Rpb2, domain 2, score 89.3, E-value 8.2e-24 282459002482 Pfam match to entry PF04561 RNA_pol_Rpb2_2, RNA polymerase Rpb2, domain 2, score 26.4, E-value 1.6e-08 282459002483 Pfam match to entry PF04565 RNA_pol_Rpb2_3, RNA polymerase Rpb2, domain 3, score 155.6, E-value 8.8e-44 282459002484 Pfam match to entry PF00562 RNA_pol_Rpb2_6, RNA polymerase Rpb2, domain 6, score 854.0, E-value 5e-254 282459002485 PS01166 RNA polymerases beta chain signature. 282459002486 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002487 Pfam match to entry PF04560 RNA_pol_Rpb2_7, RNA polymerase Rpb2, domain 7, score 175.6, E-value 8.6e-50 282459002488 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 282459002489 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 282459002490 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 282459002491 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 282459002492 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 282459002493 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 282459002494 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 282459002495 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 282459002496 G-loop; other site 282459002497 DNA binding site [nucleotide binding] 282459002498 Pfam match to entry PF04997 RNA_pol_Rpb1_1, RNA polymerase Rpb1, domain 1, score 519.1, E-value 3.3e-153 282459002499 Pfam match to entry PF00623 RNA_pol_Rpb1_2, RNA polymerase Rpb1, domain 2, score 288.5, E-value 8.7e-84 282459002500 Pfam match to entry PF04983 RNA_pol_Rpb1_3, RNA polymerase Rpb1, domain 3, score 231.1, E-value 1.6e-66 282459002501 Pfam match to entry PF05000 RNA_pol_Rpb1_4, RNA polymerase Rpb1, domain 4, score 111.7, E-value 1.4e-30 282459002502 Pfam match to entry PF04998 RNA_pol_Rpb1_5, RNA polymerase Rpb1, domain 5, score 198.6, E-value 1e-56 282459002503 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 282459002504 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 282459002505 Pfam match to entry PF01248 Ribosomal_L7Ae, Ribosomal protein L7Ae/L30e/S12e/Gadd45 family, score 66.0, E-value 8.5e-17 282459002506 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 282459002507 S17 interaction site [polypeptide binding]; other site 282459002508 S8 interaction site; other site 282459002509 16S rRNA interaction site [nucleotide binding]; other site 282459002510 streptomycin interaction site [chemical binding]; other site 282459002511 23S rRNA interaction site [nucleotide binding]; other site 282459002512 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 282459002513 Pfam match to entry PF00164 Ribosomal_S12, Ribosomal protein S12, score 241.4, E-value 1.3e-69 282459002514 PS00055 Ribosomal protein S12 signature. 282459002515 30S ribosomal protein S7; Validated; Region: PRK05302 282459002516 Pfam match to entry PF00177 Ribosomal_S7, Ribosomal protein S7p/S5e, score 327.8, E-value 1.3e-95 282459002517 PS00052 Ribosomal protein S7 signature. 282459002518 elongation factor G; Reviewed; Region: PRK00007 282459002519 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 282459002520 G1 box; other site 282459002521 putative GEF interaction site [polypeptide binding]; other site 282459002522 GTP/Mg2+ binding site [chemical binding]; other site 282459002523 Switch I region; other site 282459002524 G2 box; other site 282459002525 G3 box; other site 282459002526 Switch II region; other site 282459002527 G4 box; other site 282459002528 G5 box; other site 282459002529 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 282459002530 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 282459002531 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 282459002532 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu GTP binding domain, score 377.7, E-value 1.2e-110 282459002533 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002534 PS00301 GTP-binding elongation factors signature. 282459002535 Pfam match to entry PF03144 GTP_EFTU_D2, Elongation factor Tu domain 2, score 72.0, E-value 1.3e-18 282459002536 Pfam match to entry PF03764 EFG_IV, Elongation factor G, domain IV, score 226.1, E-value 5.5e-65 282459002537 Pfam match to entry PF00679 EFG_C, Elongation factor G C-terminus, score 174.2, E-value 2.2e-49 282459002538 elongation factor Tu; Reviewed; Region: PRK00049 282459002539 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 282459002540 G1 box; other site 282459002541 GEF interaction site [polypeptide binding]; other site 282459002542 GTP/Mg2+ binding site [chemical binding]; other site 282459002543 Switch I region; other site 282459002544 G2 box; other site 282459002545 G3 box; other site 282459002546 Switch II region; other site 282459002547 G4 box; other site 282459002548 G5 box; other site 282459002549 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 282459002550 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 282459002551 Antibiotic Binding Site [chemical binding]; other site 282459002552 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu GTP binding domain, score 333.0, E-value 3.6e-97 282459002553 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002554 PS00301 GTP-binding elongation factors signature. 282459002555 Pfam match to entry PF03144 GTP_EFTU_D2, Elongation factor Tu domain 2, score 98.5, E-value 1.4e-26 282459002556 Pfam match to entry PF03143 GTP_EFTU_D3, Elongation factor Tu C-terminal domain, score 215.9, E-value 6.5e-62 282459002557 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 282459002558 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 282459002559 metal binding site [ion binding]; metal-binding site 282459002560 dimer interface [polypeptide binding]; other site 282459002561 Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40, score 395.7, E-value 4.7e-116 282459002562 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 282459002563 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 282459002564 substrate-cofactor binding pocket; other site 282459002565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459002566 catalytic residue [active] 282459002567 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class I and II, score 149.4, E-value 6.5e-42 282459002568 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 282459002569 chaperone protein HchA; Provisional; Region: PRK04155 282459002570 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 282459002571 conserved cys residue [active] 282459002572 Pfam match to entry PF01965 DJ-1_PfpI, DJ-1/PfpI family, score 11.3, E-value 5.7e-05 282459002573 ribulokinase; Provisional; Region: PRK04123 282459002574 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 282459002575 N- and C-terminal domain interface [polypeptide binding]; other site 282459002576 active site 282459002577 MgATP binding site [chemical binding]; other site 282459002578 catalytic site [active] 282459002579 metal binding site [ion binding]; metal-binding site 282459002580 carbohydrate binding site [chemical binding]; other site 282459002581 homodimer interface [polypeptide binding]; other site 282459002582 Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases, N-terminal domain, score -43.3, E-value 2e-07 282459002583 Pfam match to entry PF02782 FGGY_C, FGGY family of carbohydrate kinases, C-terminal domain, score 32.2, E-value 1.9e-10 282459002584 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 282459002585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 282459002586 NAD(P) binding site [chemical binding]; other site 282459002587 active site 282459002588 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 282459002589 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 282459002590 homodimer interface [polypeptide binding]; other site 282459002591 substrate-cofactor binding pocket; other site 282459002592 catalytic residue [active] 282459002593 Pfam match to entry PF01063 aminotran_4, Aminotransferase class IV, score 466.5, E-value 2.3e-137 282459002594 PS00770 Aminotransferases class-IV signature. 282459002595 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 282459002596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459002597 motif II; other site 282459002598 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 99.3, E-value 7.9e-27 282459002599 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 282459002600 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 282459002601 Substrate-binding site [chemical binding]; other site 282459002602 Substrate specificity [chemical binding]; other site 282459002603 Pfam match to entry PF01712 dNK, Deoxynucleoside kinase, score 167.9, E-value 1.8e-47 282459002604 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002605 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 282459002606 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 282459002607 Substrate-binding site [chemical binding]; other site 282459002608 Substrate specificity [chemical binding]; other site 282459002609 Pfam match to entry PF01712 dNK, Deoxynucleoside kinase, score 79.8, E-value 5.7e-21 282459002610 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002611 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 282459002612 nucleoside/Zn binding site; other site 282459002613 dimer interface [polypeptide binding]; other site 282459002614 catalytic motif [active] 282459002615 Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region, score 125.2, E-value 1.3e-34 282459002616 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 282459002617 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459002618 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 282459002619 active site 282459002620 motif I; other site 282459002621 motif II; other site 282459002622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459002623 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 37.7, E-value 2.8e-08 282459002624 PS01228 Hypothetical cof family signature 1. 282459002625 PS01229 Hypothetical cof family signature 2. 282459002626 Predicted flavoprotein [General function prediction only]; Region: COG0431 282459002627 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 282459002628 Pfam match to entry PF03358 FMN_red, NADPH-dependent FMN reductase, score 59.8, E-value 6.2e-15 282459002629 Signal peptide predicted for SAS0519 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.966 between residues 50 and 51; signal peptide 282459002630 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282459002631 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 282459002632 Cna protein B-type domain; Region: Cna_B; pfam05738 282459002633 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 282459002634 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 53.1, E-value 6.2e-13 282459002635 2 probable transmembrane helices predicted for SAS0519 by TMHMM2.0 at aa 21-43 and 933-950 282459002636 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 7.0, E-value 6 282459002637 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 78.2, E-value 1.8e-20 282459002638 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 6.4, E-value 7.8 282459002639 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 70.6, E-value 3.4e-18 282459002640 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 51.9, E-value 1.5e-12 282459002641 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282459002642 Signal peptide predicted for SAS0520 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 52 and 53; signal peptide 282459002643 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282459002644 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 282459002645 Cna protein B-type domain; Region: Cna_B; pfam05738 282459002646 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 282459002647 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 282459002648 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 282459002649 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 282459002650 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 51.2, E-value 2.5e-12 282459002651 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 69.0, E-value 1.1e-17 282459002652 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 4.8, E-value 17 282459002653 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 85.5, E-value 1.1e-22 282459002654 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 7.8, E-value 4.1 282459002655 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 73.1, E-value 6.2e-19 282459002656 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 5.6, E-value 12 282459002657 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 76.1, E-value 7.5e-20 282459002658 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 6.4, E-value 7.8 282459002659 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 69.1, E-value 9.9e-18 282459002660 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 0.8, E-value 1e+02 282459002661 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 51.4, E-value 2e-12 282459002662 1 probable transmembrane helix predicted for SAS0520 by TMHMM2.0 at aa 1341-1358 282459002663 Signal peptide predicted for SAS0521 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 52 and 53; signal peptide 282459002664 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282459002665 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 282459002666 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 282459002667 Cna protein B-type domain; Region: Cna_B; pfam05738 282459002668 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 282459002669 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 51.2, E-value 2.5e-12 282459002670 2 probable transmembrane helices predicted for SAS0521 by TMHMM2.0 at aa 23-45 and 1117-1134 282459002671 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 8.2, E-value 3.5 282459002672 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 65.3, E-value 1.3e-16 282459002673 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 8.8, E-value 2.6 282459002674 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 68.0, E-value 2.1e-17 282459002675 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 6.4, E-value 7.8 282459002676 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 69.1, E-value 9.7e-18 282459002677 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 0.8, E-value 1e+02 282459002678 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 51.7, E-value 1.7e-12 282459002679 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282459002680 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 282459002681 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 282459002682 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 282459002683 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 156.7, E-value 4.2e-44 282459002684 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 282459002685 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 282459002686 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 282459002687 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 120.3, E-value 3.7e-33 282459002688 putative GTP cyclohydrolase; Provisional; Region: PRK13674 282459002689 Pfam match to entry PF02649 DUF198, Uncharacterized ACR, COG1469, score 207.2, E-value 2.7e-59 282459002690 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 282459002691 Pfam match to entry PF02585 DUF158, Uncharacterised LmbE-like protein, COG2120, score 8.8, E-value 2.8e-08 282459002692 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 282459002693 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 282459002694 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 282459002695 active site 282459002696 trimer interface [polypeptide binding]; other site 282459002697 allosteric site; other site 282459002698 active site lid [active] 282459002699 hexamer (dimer of trimers) interface [polypeptide binding]; other site 282459002700 Pfam match to entry PF01182 Glucosamine_iso, Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase, score 193.7, E-value 3.1e-55 282459002701 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 282459002702 active site 282459002703 dimer interface [polypeptide binding]; other site 282459002704 magnesium binding site [ion binding]; other site 282459002705 Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylase / HUMPS family, score 196.9, E-value 3.4e-56 282459002706 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 282459002707 tetramer interface [polypeptide binding]; other site 282459002708 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 282459002709 active site 282459002710 Pfam match to entry PF01380 SIS, SIS domain, score 47.7, E-value 2.8e-11 282459002711 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 282459002712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459002713 motif II; other site 282459002714 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 104.5, E-value 2.1e-28 282459002715 proline/glycine betaine transporter; Provisional; Region: PRK10642 282459002716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459002717 putative substrate translocation pore; other site 282459002718 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score 152.4, E-value 8.4e-43 282459002719 12 probable transmembrane helices predicted for SAS0531 by TMHMM2.0 at aa 20-42, 62-84, 91-113, 118-140, 160-182, 192-211, 242-264, 279-301, 313-332, 337-354, 375-397 and 407-429 282459002720 PS00217 Sugar transport proteins signature 2. 282459002721 2 probable transmembrane helices predicted for SAS0532 by TMHMM2.0 at aa 28-50 and 71-93 282459002722 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 282459002723 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 282459002724 acyl-activating enzyme (AAE) consensus motif; other site 282459002725 AMP binding site [chemical binding]; other site 282459002726 active site 282459002727 CoA binding site [chemical binding]; other site 282459002728 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 100.2, E-value 4.4e-27 282459002729 PS00455 AMP-binding domain signature. 282459002730 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 282459002731 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 282459002732 dimer interface [polypeptide binding]; other site 282459002733 active site 282459002734 Pfam match to entry PF00108 thiolase, Thiolase, N-terminal domain, score 196.7, E-value 3.9e-56 282459002735 Pfam match to entry PF02803 thiolase_C, Thiolase, C-terminal domain, score 113.0, E-value 5.8e-31 282459002736 PS00737 Thiolases signature 2. 282459002737 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 282459002738 dimer interface [polypeptide binding]; other site 282459002739 substrate binding site [chemical binding]; other site 282459002740 ATP binding site [chemical binding]; other site 282459002741 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002742 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 282459002743 ligand binding site [chemical binding]; other site 282459002744 active site 282459002745 UGI interface [polypeptide binding]; other site 282459002746 catalytic site [active] 282459002747 Pfam match to entry PF03167 UDG, Uracil DNA glycosylase superfamily, score 246.1, E-value 5e-71 282459002748 PS00130 Uracil-DNA glycosylase signature. 282459002749 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 282459002750 Signal peptide predicted for SAS0541 by SignalP 2.0 HMM (Signal peptide probabilty 0.970) with cleavage site probability 0.657 between residues 22 and 23; signal peptide 282459002751 4 probable transmembrane helices predicted for SAS0541 by TMHMM2.0 at aa 4-26, 47-64, 68-87 and 94-116 282459002752 Pfam match to entry PF04241 DUF423, Protein of unknown function (DUF423), score 221.2, E-value 1.6e-63 282459002753 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 282459002754 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score -9.8, E-value 1.9e-07 282459002755 12 probable transmembrane helices predicted for SAS0542 by TMHMM2.0 at aa 21-40, 50-72, 93-115, 138-160, 173-195, 210-229, 249-271, 291-313, 346-365, 375-397, 410-429 and 434-456 282459002756 Uncharacterized conserved protein [Function unknown]; Region: COG3610 282459002757 4 probable transmembrane helices predicted for SAS0543 by TMHMM2.0 at aa 2-24, 44-66, 78-100 and 110-132 282459002758 Uncharacterized conserved protein [Function unknown]; Region: COG2966 282459002759 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 282459002760 4 probable transmembrane helices predicted for SAS0544 by TMHMM2.0 at aa 138-160, 170-192, 197-219 and 234-253 282459002761 putative heme peroxidase; Provisional; Region: PRK12276 282459002762 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 282459002763 Pfam match to entry PF01515 PTA_PTB, Phosphate acetyl/butaryl transferase, score 541.8, E-value 4.9e-160 282459002764 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 282459002765 Pfam match to entry PF03099 BPL_LipA_LipB, Biotin/lipoate A/B protein ligase family, score 27.9, E-value 2.2e-05 282459002766 mevalonate kinase; Region: mevalon_kin; TIGR00549 282459002767 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 282459002768 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 282459002769 Pfam match to entry PF00288 GHMP_kinases, GHMP kinases ATP-binding protein, score 149.4, E-value 6.4e-42 282459002770 PS00627 GHMP kinases ATP-binding domain. 282459002771 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 282459002772 diphosphomevalonate decarboxylase; Region: PLN02407 282459002773 Pfam match to entry PF00288 GHMP_kinases, GHMP kinases ATP-binding protein, score 152.0, E-value 1.1e-42 282459002774 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 282459002775 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 282459002776 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 282459002777 Pfam match to entry PF00288 GHMP_kinases, GHMP kinases ATP-binding protein, score 134.3, E-value 2.4e-37 282459002778 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 282459002779 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 282459002780 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 282459002781 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282459002782 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 282459002783 Pfam match to entry PF02852 pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 95.3, E-value 1.2e-25 282459002784 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 272.0, E-value 8.1e-79 282459002785 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002786 Predicted transcriptional regulator [Transcription]; Region: COG1959 282459002787 Transcriptional regulator; Region: Rrf2; pfam02082 282459002788 Predicted helix-turn-helix motif for SAS0554 with score 1199.000, SD 3.27 at aa 23-44, sequence FNSSSLAELTCLNPVQLRRVTT 282459002789 LXG domain of WXG superfamily; Region: LXG; pfam04740 282459002790 1 probable transmembrane helix predicted for SAS0555 by TMHMM2.0 at aa 389-411 282459002791 Protein of unknown function (DUF443); Region: DUF443; pfam04276 282459002792 Pfam match to entry PF04276 DUF443, Protein of unknown function (DUF443), score 245.1, E-value 1e-70 282459002793 5 probable transmembrane helices predicted for SAS0556 by TMHMM2.0 at aa 23-45, 67-84, 99-118, 148-170 and 175-197 282459002794 Protein of unknown function (DUF443); Region: DUF443; pfam04276 282459002795 Pfam match to entry PF04276 DUF443, Protein of unknown function (DUF443), score 294.3, E-value 1.5e-85 282459002796 5 probable transmembrane helices predicted for SAS0557 by TMHMM2.0 at aa 23-45, 65-84, 99-118, 145-167 and 171-190 282459002797 Protein of unknown function (DUF443); Region: DUF443; pfam04276 282459002798 Pfam match to entry PF04276 DUF443, Protein of unknown function (DUF443), score 290.1, E-value 3e-84 282459002799 5 probable transmembrane helices predicted for SAS0558 by TMHMM2.0 at aa 23-45, 70-89, 99-118, 147-169 and 174-196 282459002800 Protein of unknown function (DUF443); Region: DUF443; pfam04276 282459002801 Pfam match to entry PF04276 DUF443, Protein of unknown function (DUF443), score 274.3, E-value 1.6e-79 282459002802 5 probable transmembrane helices predicted for SAS0559 by TMHMM2.0 at aa 23-45, 70-89, 99-118, 138-160 and 175-197 282459002803 Similar to Oceanobacillus iheyensis hypothetical conserved protein ob3290 SWALL:Q8ELD9 (EMBL:AP004604) (212 aa) fasta scores: E(): 0.00024, 21.71% id in 221 aa, and to Staphylococcus haemolyticus hypothetical protein SWALL:Q9F2H5 (EMBL:AJ302698) (220 aa) fasta scores: E(): 5.1e-07, 25.25% id in 198 aa. CDS contains a frameshift after codon 142. Frameshift occurs at a poly A hexamer; membrane protein (pseudogene) 282459002804 Pfam match to entry PF04276 DUF443, Protein of unknown function (DUF443), score 211.2, E-value 1.7e-60 282459002805 5 probable transmembrane helices predicted for SAS0560 by TMHMM2.0 at aa 23-45, 69-84, 99-116, 137-159 and 174-196 282459002806 Protein of unknown function (DUF443); Region: DUF443; pfam04276 282459002807 Pfam match to entry PF04276 DUF443, Protein of unknown function (DUF443), score 435.6, E-value 4.6e-128 282459002808 5 probable transmembrane helices predicted for SAS0562 by TMHMM2.0 at aa 26-48, 72-89, 102-121, 150-172 and 179-201 282459002809 Protein of unknown function (DUF443); Region: DUF443; pfam04276 282459002810 Pfam match to entry PF04276 DUF443, Protein of unknown function (DUF443), score 252.8, E-value 5e-73 282459002811 5 probable transmembrane helices predicted for SAS0563 by TMHMM2.0 at aa 23-45, 65-84, 99-118, 147-169 and 174-196 282459002812 Protein of unknown function (DUF443); Region: DUF443; pfam04276 282459002813 Pfam match to entry PF04276 DUF443, Protein of unknown function (DUF443), score 278.4, E-value 9.5e-81 282459002814 5 probable transmembrane helices predicted for SAS0564 by TMHMM2.0 at aa 24-46, 70-89, 99-118, 138-160 and 175-197 282459002815 Protein of unknown function (DUF443); Region: DUF443; pfam04276 282459002816 Pfam match to entry PF04276 DUF443, Protein of unknown function (DUF443), score 270.6, E-value 2.1e-78 282459002817 5 probable transmembrane helices predicted for SAS0565 by TMHMM2.0 at aa 26-48, 70-87, 102-121, 151-173 and 178-200 282459002818 Protein of unknown function (DUF443); Region: DUF443; pfam04276 282459002819 Pfam match to entry PF04276 DUF443, Protein of unknown function (DUF443), score 293.0, E-value 3.8e-85 282459002820 5 probable transmembrane helices predicted for SAS0566 by TMHMM2.0 at aa 23-45, 70-89, 99-118, 147-169 and 174-196 282459002821 Protein of unknown function (DUF443); Region: DUF443; pfam04276 282459002822 Pfam match to entry PF04276 DUF443, Protein of unknown function (DUF443), score 391.2, E-value 1.1e-114 282459002823 4 probable transmembrane helices predicted for SAS0567 by TMHMM2.0 at aa 24-46, 100-117, 138-160 and 175-197 282459002824 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 282459002825 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 282459002826 active site 282459002827 catalytic tetrad [active] 282459002828 Pfam match to entry PF00248 aldo_ket_red, Aldo/keto reductase family, score 245.3, E-value 8.8e-71 282459002829 PS00062 Aldo/keto reductase family signature 2. 282459002830 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 282459002831 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 282459002832 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 282459002833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459002834 Coenzyme A binding pocket [chemical binding]; other site 282459002835 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 59.3, E-value 8.8e-15 282459002836 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 282459002837 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 282459002838 Zn2+ binding site [ion binding]; other site 282459002839 Mg2+ binding site [ion binding]; other site 282459002840 Pfam match to entry PF01966 HD, HD domain, score 47.6, E-value 2.9e-11 282459002841 YwhD family; Region: YwhD; pfam08741 282459002842 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 282459002843 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 282459002844 NAD binding site [chemical binding]; other site 282459002845 substrate binding site [chemical binding]; other site 282459002846 catalytic Zn binding site [ion binding]; other site 282459002847 tetramer interface [polypeptide binding]; other site 282459002848 structural Zn binding site [ion binding]; other site 282459002849 Pfam match to entry PF00107 ADH_zinc_N, Zinc-binding dehydrogenase, score 359.1, E-value 4.8e-105 282459002850 PS00190 Cytochrome c family heme-binding site signature. 282459002851 PS00059 Zinc-containing alcohol dehydrogenases signature. 282459002852 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 282459002853 1 probable transmembrane helix predicted for SAS0573a by TMHMM2.0 at aa 7-29 282459002854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 282459002855 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 282459002856 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 282459002857 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 282459002858 active site 282459002859 HIGH motif; other site 282459002860 KMSK motif region; other site 282459002861 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 282459002862 tRNA binding surface [nucleotide binding]; other site 282459002863 anticodon binding site; other site 282459002864 Pfam match to entry PF03485 N-Arg, Arginyl tRNA synthetase N terminal domain, score 122.8, E-value 6.9e-34 282459002865 Pfam match to entry PF00750 tRNA-synt_1d, tRNA synthetases class I (R), score 310.8, E-value 1.8e-90 282459002866 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282459002867 Pfam match to entry PF05746 tRNA-synt_1d_C, Arginyl tRNA synthetase anticodon binding domain, score 179.6, E-value 5.3e-51 282459002868 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 282459002869 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 282459002870 minor groove reading motif; other site 282459002871 helix-hairpin-helix signature motif; other site 282459002872 substrate binding pocket [chemical binding]; other site 282459002873 active site 282459002874 Signal peptide predicted for SAS0577 by SignalP 2.0 HMM (Signal peptide probabilty 0.909) with cleavage site probability 0.361 between residues 26 and 27; signal peptide 282459002875 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 282459002876 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 282459002877 putative binding site residues; other site 282459002878 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459002879 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 97.1, E-value 3.6e-26 282459002880 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282459002881 ABC-ATPase subunit interface; other site 282459002882 dimer interface [polypeptide binding]; other site 282459002883 putative PBP binding regions; other site 282459002884 10 probable transmembrane helices predicted for SAS0578 by TMHMM2.0 at aa 7-26, 46-68, 75-97, 101-123, 130-152, 175-197, 210-229, 233-250, 263-285 and 290-309 282459002885 Pfam match to entry PF01032 FecCD, FecCD transport family, score 155.1, E-value 1.3e-43 282459002886 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 282459002887 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459002888 motif II; other site 282459002889 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 82.8, E-value 7.3e-22 282459002890 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002891 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 282459002892 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 282459002893 Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold, score 44.3, E-value 2.9e-10 282459002894 Signal peptide predicted for SAS0581 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.887 between residues 27 and 28; signal peptide 282459002895 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002896 5 probable transmembrane helices predicted for SAS0582 by TMHMM2.0 at aa 66-88, 98-120, 132-154, 164-183 and 212-234 282459002897 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 282459002898 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 282459002899 Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold, score 102.8, E-value 7.2e-28 282459002900 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282459002901 Transcriptional regulators [Transcription]; Region: MarR; COG1846 282459002902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 282459002903 Protein of unknown function, DUF606; Region: DUF606; pfam04657 282459002904 10 probable transmembrane helices predicted for SAS0585 by TMHMM2.0 at aa 4-26, 33-54, 69-91, 98-120, 130-148, 160-182, 192-214, 233-255, 259-281 and 294-308 282459002905 Pfam match to entry PF04657 DUF606, Protein of unknown function, DUF606, score 120.0, E-value 4.5e-33 282459002906 Pfam match to entry PF04657 DUF606, Protein of unknown function, DUF606, score 237.7, E-value 1.7e-68 282459002907 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 282459002908 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 282459002909 active site 282459002910 DNA binding site [nucleotide binding] 282459002911 Int/Topo IB signature motif; other site 282459002912 Pfam match to entry PF00589 Phage_integrase, Phage integrase family, score 42.5, E-value 9.7e-10 282459002913 Predicted helix-turn-helix motif for SAS0588 with score 1046.000, SD 2.75 at aa 36-57, sequence HSGLKVSELLTITVSQVKRLIE 282459002914 Signal peptide predicted for SAS0589 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.771 between residues 27 and 28; signal peptide 282459002915 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 282459002916 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 282459002917 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 282459002918 21 probable transmembrane helices predicted for SAS0589 by TMHMM2.0 at aa 4-21, 30-52, 76-98, 111-128, 132-154, 167-189, 209-231, 244-266, 271-293, 300-320, 330-352, 385-407, 427-449, 473-495, 525-547, 591-613, 628-647, 654-671, 676-698, 711-733 and 770-789 282459002919 Pfam match to entry PF00662 oxidored_q1_N, NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus, score 31.1, E-value 2.8e-06 282459002920 Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 246.8, E-value 3.1e-71 282459002921 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 282459002922 4 probable transmembrane helices predicted for SAS0590 by TMHMM2.0 at aa 7-29, 34-56, 68-90 and 114-136 282459002923 Pfam match to entry PF04039 MnhB, Domain related to MnhB subunit of Na+/H+ antiporter, score 152.2, E-value 9.5e-43 282459002924 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 282459002925 Pfam match to entry PF00420 oxidored_q2, NADH-ubiquinone/plastoquinone oxidoreductase chain 4L, score 65.6, E-value 1.1e-16 282459002926 3 probable transmembrane helices predicted for SAS0591 by TMHMM2.0 at aa 4-26, 28-50 and 70-92 282459002927 Signal peptide predicted for SAS0592 by SignalP 2.0 HMM (Signal peptide probabilty 0.945) with cleavage site probability 0.581 between residues 23 and 24; signal peptide 282459002928 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 282459002929 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 282459002930 14 probable transmembrane helices predicted for SAS0592 by TMHMM2.0 at aa 5-23, 30-52, 77-99, 108-127, 131-153, 160-182, 206-228, 235-257, 270-292, 299-321, 326-348, 368-390, 405-427 and 451-473 282459002931 Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 176.3, E-value 5.1e-50 282459002932 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 282459002933 3 probable transmembrane helices predicted for SAS0593 by TMHMM2.0 at aa 25-47, 60-82 and 102-120 282459002934 Pfam match to entry PF01899 MNHE, Na+/H+ ion antiporter subunit, score 0.1, E-value 3.7e-05 282459002935 Signal peptide predicted for SAS0594 by SignalP 2.0 HMM (Signal peptide probabilty 0.792) with cleavage site probability 0.468 between residues 35 and 36; signal peptide 282459002936 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 282459002937 3 probable transmembrane helices predicted for SAS0594 by TMHMM2.0 at aa 4-26, 38-60 and 70-92 282459002938 Pfam match to entry PF04066 MrpF_PhaF, Multiple resistance and pH regulation protein F (MrpF / PhaF), score 82.3, E-value 1e-21 282459002939 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 282459002940 Signal peptide predicted for SAS0595 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.512 between residues 27 and 28; signal peptide 282459002941 Pfam match to entry PF03334 PhaG_MnhG_YufB, Na+/H+ antiporter subunit, score 88.4, E-value 1.6e-23 282459002942 3 probable transmembrane helices predicted for SAS0595 by TMHMM2.0 at aa 7-29, 49-71 and 73-95 282459002943 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 282459002944 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 282459002945 Pfam match to entry PF00999 Na_H_Exchanger, Sodium/hydrogen exchanger family, score 214.0, E-value 2.4e-61 282459002946 13 probable transmembrane helices predicted for SAS0596 by TMHMM2.0 at aa 7-24, 29-51, 84-106, 111-133, 153-175, 180-202, 215-234, 238-255, 276-298, 308-325, 327-349, 369-391 and 404-426 282459002947 Signal peptide predicted for SAS0597 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.322 between residues 24 and 25; signal peptide 282459002948 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 282459002949 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 282459002950 metal binding site [ion binding]; metal-binding site 282459002951 Pfam match to entry PF01297 SBP_bac_9, Periplasmic solute binding protein family, score 486.0, E-value 3.1e-143 282459002952 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002953 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459002954 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 282459002955 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282459002956 ABC-ATPase subunit interface; other site 282459002957 dimer interface [polypeptide binding]; other site 282459002958 putative PBP binding regions; other site 282459002959 Pfam match to entry PF00950 ABC-3, ABC 3 transport family, score 362.1, E-value 6e-106 282459002960 8 probable transmembrane helices predicted for SAS0598 by TMHMM2.0 at aa 13-35, 50-81, 93-115, 130-152, 165-187, 192-214, 221-243 and 248-265 282459002961 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 282459002962 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 282459002963 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 156.6, E-value 4.6e-44 282459002964 PS00211 ABC transporters family signature. 282459002965 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002966 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 282459002967 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 282459002968 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 282459002969 FeoA domain; Region: FeoA; pfam04023 282459002970 Pfam match to entry PF01325 Fe_dep_repress, Iron dependent repressor, N-terminal DNA binding domain, score 110.6, E-value 3.1e-30 282459002971 Pfam match to entry PF02742 Fe_dep_repr_C, Iron dependent repressor, metal binding and dimerisation domain, score 115.7, E-value 9.3e-32 282459002972 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 282459002973 6 probable transmembrane helices predicted for SAS0601 by TMHMM2.0 at aa 7-29, 96-118, 125-144, 148-165, 170-192 and 221-243 282459002974 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282459002975 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 282459002976 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 282459002977 Pfam match to entry PF03808 Glyco_tran_WecB, Glycosyl transferase WecB/TagA/CpsF family, score 313.8, E-value 2.1e-91 282459002978 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 282459002979 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 282459002980 Walker A/P-loop; other site 282459002981 ATP binding site [chemical binding]; other site 282459002982 Q-loop/lid; other site 282459002983 ABC transporter signature motif; other site 282459002984 Walker B; other site 282459002985 D-loop; other site 282459002986 H-loop/switch region; other site 282459002987 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 104.0, E-value 3.1e-28 282459002988 PS00211 ABC transporters family signature. 282459002989 PS00017 ATP/GTP-binding site motif A (P-loop). 282459002990 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 282459002991 ABC-2 type transporter; Region: ABC2_membrane; cl17235 282459002992 Pfam match to entry PF01061 ABC2_membrane, ABC-2 type transporter, score 142.7, E-value 6.7e-40 282459002993 6 probable transmembrane helices predicted for SAS0604 by TMHMM2.0 at aa 40-62, 77-96, 132-154, 158-180, 192-214 and 247-266 282459002994 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 282459002995 Pfam match to entry PF04464 glyphos_transf, CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase, score 62.0, E-value 1.3e-15 282459002996 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 282459002997 active site 282459002998 Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferase, score 33.4, E-value 5.4e-07 282459002999 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 282459003000 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 282459003001 active site 282459003002 nucleotide binding site [chemical binding]; other site 282459003003 HIGH motif; other site 282459003004 KMSKS motif; other site 282459003005 Pfam match to entry PF01467 CTP_transf_2, Cytidylyltransferase, score 96.9, E-value 4.3e-26 282459003006 Signal peptide predicted for SAS0608 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.630 between residues 24 and 25; signal peptide 282459003007 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 282459003008 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 282459003009 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 282459003010 1 probable transmembrane helix predicted for SAS0608 by TMHMM2.0 at aa 401-423 282459003011 Pfam match to entry PF00768 Peptidase_S11, D-alanyl-D-alanine carboxypeptidase, score 279.8, E-value 3.7e-81 282459003012 Signal peptide predicted for SAS0609 by SignalP 2.0 HMM (Signal peptide probabilty 0.937) with cleavage site probability 0.397 between residues 44 and 45; signal peptide 282459003013 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 282459003014 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 282459003015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282459003016 Walker A/P-loop; other site 282459003017 ATP binding site [chemical binding]; other site 282459003018 Q-loop/lid; other site 282459003019 ABC transporter signature motif; other site 282459003020 Walker B; other site 282459003021 D-loop; other site 282459003022 H-loop/switch region; other site 282459003023 6 probable transmembrane helices predicted for SAS0609 by TMHMM2.0 at aa 21-43, 58-80, 134-153, 158-180, 238-260 and 270-292 282459003024 Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region, score 150.1, E-value 3.9e-42 282459003025 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 205.0, E-value 1.2e-58 282459003026 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003027 PS00211 ABC transporters family signature. 282459003028 similar to hypothetical protein; Ortholog of S. aureus MRSA252 (BX571856) SAR0654; No significant database hits 282459003029 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 282459003030 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 282459003031 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 282459003032 Pfam match to entry PF01773 Nucleoside_tra2, Na+ dependent nucleoside transporter, score 332.2, E-value 5.9e-97 282459003033 10 probable transmembrane helices predicted for SAS0610 by TMHMM2.0 at aa 2-21, 27-49, 62-81, 91-113, 165-187, 192-214, 243-265, 294-316, 348-370 and 385-407 282459003034 Uncharacterized conserved protein [Function unknown]; Region: COG1284 282459003035 Signal peptide predicted for SAS0611 by SignalP 2.0 HMM (Signal peptide probabilty 0.965) with cleavage site probability 0.569 between residues 24 and 25; signal peptide 282459003036 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 282459003037 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 282459003038 Pfam match to entry PF02588 DUF161, Uncharacterized BCR, YitT family COG1284, score 89.7, E-value 6.1e-24 282459003039 5 probable transmembrane helices predicted for SAS0611 by TMHMM2.0 at aa 9-31, 41-63, 75-97, 112-134 and 147-166 282459003040 Pfam match to entry PF02588 DUF161, Uncharacterized BCR, YitT family COG1284, score 64.7, E-value 2.1e-16 282459003041 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 282459003042 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 282459003043 Walker A/P-loop; other site 282459003044 ATP binding site [chemical binding]; other site 282459003045 Q-loop/lid; other site 282459003046 ABC transporter signature motif; other site 282459003047 Walker B; other site 282459003048 D-loop; other site 282459003049 H-loop/switch region; other site 282459003050 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 217.9, E-value 1.5e-62 282459003051 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003052 PS00211 ABC transporters family signature. 282459003053 Signal peptide predicted for SAS0613 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.880 between residues 40 and 41; signal peptide 282459003054 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 282459003055 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282459003056 ABC-ATPase subunit interface; other site 282459003057 dimer interface [polypeptide binding]; other site 282459003058 putative PBP binding regions; other site 282459003059 9 probable transmembrane helices predicted for SAS0613 by TMHMM2.0 at aa 12-34, 63-85, 98-117, 121-143, 155-177, 201-223, 244-266, 276-298 and 305-327 282459003060 Pfam match to entry PF01032 FecCD, FecCD transport family, score 381.8, E-value 7.5e-112 282459003061 Signal peptide predicted for SAS0614 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.246 between residues 28 and 29; signal peptide 282459003062 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 282459003063 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282459003064 ABC-ATPase subunit interface; other site 282459003065 dimer interface [polypeptide binding]; other site 282459003066 putative PBP binding regions; other site 282459003067 9 probable transmembrane helices predicted for SAS0614 by TMHMM2.0 at aa 12-31, 65-82, 95-112, 122-144, 151-173, 198-217, 247-269, 284-301 and 308-330 282459003068 Pfam match to entry PF01032 FecCD, FecCD transport family, score 356.9, E-value 2.3e-104 282459003069 PS00267 Tachykinin family signature. 282459003070 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 282459003071 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 282459003072 Pfam match to entry PF02733 Dak1, Dak1 domain, score 357.9, E-value 1.1e-104 282459003073 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 282459003074 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 282459003075 Pfam match to entry PF02734 Dak2, DAK2 domain, score 78.7, E-value 1.3e-20 282459003076 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 282459003077 Pfam match to entry PF03610 EIIA-man, PTS system fructose IIA component, score 146.2, E-value 5.9e-41 282459003078 Uncharacterized membrane protein [Function unknown]; Region: COG3949 282459003079 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 282459003080 Na binding site [ion binding]; other site 282459003081 Pfam match to entry PF05525 Branch_AA_trans, Branched-chain amino acid transport protein, score -306.9, E-value 0.0023 282459003082 10 probable transmembrane helices predicted for SAS0619 by TMHMM2.0 at aa 7-26, 36-55, 85-107, 117-134, 141-163, 186-208, 215-237, 264-286, 299-321 and 325-344 282459003083 PS00251 TNF family signature. 282459003084 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 282459003085 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 282459003086 substrate binding pocket [chemical binding]; other site 282459003087 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 282459003088 1 probable transmembrane helix predicted for SAS0620 by TMHMM2.0 at aa 7-26 282459003089 Pfam match to entry PF00135 COesterase, Carboxylesterase, score 12.8, E-value 0.00042 282459003090 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 282459003091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459003092 Coenzyme A binding pocket [chemical binding]; other site 282459003093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 282459003094 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 64.3, E-value 2.7e-16 282459003095 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 282459003096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 282459003097 NAD(P) binding site [chemical binding]; other site 282459003098 active site 282459003099 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282459003100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459003101 active site 282459003102 phosphorylation site [posttranslational modification] 282459003103 intermolecular recognition site; other site 282459003104 dimerization interface [polypeptide binding]; other site 282459003105 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282459003106 DNA binding site [nucleotide binding] 282459003107 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 78.2, E-value 1.8e-20 282459003108 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 72.9, E-value 7.1e-19 282459003109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 282459003110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 282459003111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459003112 ATP binding site [chemical binding]; other site 282459003113 Mg2+ binding site [ion binding]; other site 282459003114 G-X-G motif; other site 282459003115 2 probable transmembrane helices predicted for SAS0625 by TMHMM2.0 at aa 17-34 and 44-63 282459003116 Pfam match to entry PF00512 HisKA, His Kinase A (phosphoacceptor) domain, score 23.3, E-value 0.00036 282459003117 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 104.3, E-value 2.5e-28 282459003118 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 282459003119 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282459003120 Walker A/P-loop; other site 282459003121 ATP binding site [chemical binding]; other site 282459003122 Q-loop/lid; other site 282459003123 ABC transporter signature motif; other site 282459003124 Walker B; other site 282459003125 D-loop; other site 282459003126 H-loop/switch region; other site 282459003127 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 198.6, E-value 1e-56 282459003128 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003129 10 probable transmembrane helices predicted for SAS0627 by TMHMM2.0 at aa 20-38, 58-80, 100-122, 154-176, 197-219, 229-251, 286-308, 509-531, 565-587 and 597-619 282459003130 Pfam match to entry PF02687 FtsX, Predicted permease, score 7.6, E-value 0.00012 282459003131 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 282459003132 Pfam match to entry PF01865 PhoU_div, Protein of unknown function DUF47, score 6.9, E-value 3.8e-06 282459003133 Signal peptide predicted for SAS0629 by SignalP 2.0 HMM (Signal peptide probabilty 0.965) with cleavage site probability 0.858 between residues 30 and 31; signal peptide 282459003134 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 282459003135 7 probable transmembrane helices predicted for SAS0629 by TMHMM2.0 at aa 2-24, 46-68, 81-103, 108-130, 137-159, 221-243 and 309-331 282459003136 Pfam match to entry PF01384 PHO4, Phosphate transporter family, score 343.2, E-value 2.9e-100 282459003137 Signal peptide predicted for SAS0630 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 25 and 26; signal peptide 282459003138 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282459003139 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 282459003140 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282459003141 Surface antigen [General function prediction only]; Region: COG3942 282459003142 CHAP domain; Region: CHAP; pfam05257 282459003143 Pfam match to entry PF05257 CHAP, CHAP domain, score 186.2, E-value 5.3e-53 282459003144 Pfam match to entry PF01476 LysM, LysM domain, score 65.4, E-value 1.3e-16 282459003145 Pfam match to entry PF01476 LysM, LysM domain, score 65.8, E-value 9.6e-17 282459003146 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 282459003147 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 282459003148 6 probable transmembrane helices predicted for SAS0631 by TMHMM2.0 at aa 21-43, 47-64, 71-93, 103-125, 130-152 and 156-175 282459003149 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 282459003150 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 22.4, E-value 0.0011 282459003151 Predicted helix-turn-helix motif for SAS0632 with score 1764.000, SD 5.19 at aa 168-189, sequence LTLKSVADKLFVSKSNLSSQFH 282459003152 PS00041 Bacterial regulatory proteins, araC family signature. 282459003153 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 48.1, E-value 2.1e-11 282459003154 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282459003155 hypothetical protein; Provisional; Region: PRK12378 282459003156 Pfam match to entry PF01709 DUF28, Domain of unknown function DUF28, score 402.1, E-value 5.7e-118 282459003157 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 282459003158 Pfam match to entry PF06172 DUF985, Protein of unknown function (DUF985), score 301.8, E-value 8.9e-88 282459003159 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 282459003160 Pfam match to entry PF04167 DUF402, Protein of unknown function (DUF402), score 128.9, E-value 1e-35 282459003161 Transcriptional regulator [Transcription]; Region: LysR; COG0583 282459003162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 282459003163 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 282459003164 dimerization interface [polypeptide binding]; other site 282459003165 Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 60.3, E-value 4.4e-15 282459003166 Predicted helix-turn-helix motif for SAS0637 with score 1745.000, SD 5.13 at aa 16-37, sequence KTLRKAAEILYISQPAVTQRLK 282459003167 PS00044 Bacterial regulatory proteins, lysR family signature. 282459003168 Pfam match to entry PF03466 LysR_substrate, LysR substrate binding domain, score 76.1, E-value 7.9e-20 282459003169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459003170 sugar efflux transporter; Region: 2A0120; TIGR00899 282459003171 putative substrate translocation pore; other site 282459003172 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -115.2, E-value 0.0034 282459003173 12 probable transmembrane helices predicted for SAS0638 by TMHMM2.0 at aa 13-35, 45-67, 80-99, 103-125, 145-167, 171-193, 220-242, 257-279, 286-305, 311-333, 340-359 and 369-391 282459003174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 282459003175 5 probable transmembrane helices predicted for SAS0639 by TMHMM2.0 at aa 2-21, 25-42, 47-69, 89-111 and 132-154 282459003176 Pfam match to entry PF04306 DUF456, Protein of unknown function (DUF456), score 306.1, E-value 4.5e-89 282459003177 Serine incorporator (Serinc); Region: Serinc; pfam03348 282459003178 4 probable transmembrane helices predicted for SAS0640 by TMHMM2.0 at aa 95-117, 127-149, 162-184 and 194-216 282459003179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459003180 Coenzyme A binding pocket [chemical binding]; other site 282459003181 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 59.4, E-value 8.4e-15 282459003182 Signal peptide predicted for SAS0642 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.552 between residues 25 and 26; signal peptide 282459003183 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459003184 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 282459003185 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 282459003186 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 50.9, E-value 3e-12 282459003187 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 282459003188 Pfam match to entry PF03641 Lysine_decarbox, Lysine decarboxylase family, score 237.0, E-value 2.8e-68 282459003189 hypothetical protein; Validated; Region: PRK00124 282459003190 Pfam match to entry PF02639 DUF188, Uncharacterized BCR, YaiI/YqxD family COG1671, score 81.3, E-value 2.1e-21 282459003191 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 282459003192 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 282459003193 8 probable transmembrane helices predicted for SAS0648 by TMHMM2.0 at aa 9-31, 46-68, 99-118, 128-145, 162-181, 201-223, 236-258 and 268-287 282459003194 Pfam match to entry PF02673 BacA, Bacitracin resistance protein BacA, score 460.8, E-value 1.2e-135 282459003195 Signal peptide predicted for SAS0649 by SignalP 2.0 HMM (Signal peptide probabilty 0.961) with cleavage site probability 0.594 between residues 37 and 38; signal peptide 282459003196 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 282459003197 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 282459003198 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 282459003199 Walker A/P-loop; other site 282459003200 ATP binding site [chemical binding]; other site 282459003201 Q-loop/lid; other site 282459003202 ABC transporter signature motif; other site 282459003203 Walker B; other site 282459003204 D-loop; other site 282459003205 H-loop/switch region; other site 282459003206 Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region, score 36.8, E-value 5.3e-08 282459003207 5 probable transmembrane helices predicted for SAS0649 by TMHMM2.0 at aa 13-35, 50-72, 125-142, 147-166 and 227-249 282459003208 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 155.8, E-value 7.9e-44 282459003209 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003210 PS00211 ABC transporters family signature. 282459003211 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 282459003212 Signal peptide predicted for SAS0650 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.906 between residues 44 and 45; signal peptide 282459003213 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 282459003214 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 282459003215 Walker A/P-loop; other site 282459003216 ATP binding site [chemical binding]; other site 282459003217 Q-loop/lid; other site 282459003218 ABC transporter signature motif; other site 282459003219 Walker B; other site 282459003220 D-loop; other site 282459003221 H-loop/switch region; other site 282459003222 Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region, score 6.4, E-value 0.0008 282459003223 5 probable transmembrane helices predicted for SAS0650 by TMHMM2.0 at aa 13-35, 45-67, 123-145, 149-171 and 240-262 282459003224 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 147.3, E-value 2.9e-41 282459003225 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003226 PS00211 ABC transporters family signature. 282459003227 Transcriptional regulators [Transcription]; Region: MarR; COG1846 282459003228 MarR family; Region: MarR; pfam01047 282459003229 Pfam match to entry PF01047 MarR, MarR family, score 78.5, E-value 1.5e-20 282459003230 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 282459003231 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 282459003232 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 282459003233 Pfam match to entry PF02492 cobW, Cobalamin synthesis protein/P47K, score 411.8, E-value 6.8e-121 282459003234 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003235 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 282459003236 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 282459003237 active site 282459003238 catalytic tetrad [active] 282459003239 Pfam match to entry PF00248 aldo_ket_red, Aldo/keto reductase family, score 125.3, E-value 1.2e-34 282459003240 3 probable transmembrane helices predicted for SAS0654 by TMHMM2.0 at aa 17-36, 41-62 and 69-91 282459003241 Signal peptide predicted for SAS0655 by SignalP 2.0 HMM (Signal peptide probabilty 0.896) with cleavage site probability 0.618 between residues 52 and 53; signal peptide 282459003242 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 282459003243 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 282459003244 transmembrane helices; other site 282459003245 Pfam match to entry PF00939 Na_sulph_symp, Sodium:sulfate symporter transmembrane region, score 374.9, E-value 8.7e-110 282459003246 12 probable transmembrane helices predicted for SAS0655 by TMHMM2.0 at aa 25-42, 46-65, 70-92, 122-144, 169-191, 257-279, 329-348, 363-382, 395-417, 421-443, 450-472 and 492-514 282459003247 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 282459003248 DNA photolyase; Region: DNA_photolyase; pfam00875 282459003249 Pfam match to entry PF03441 FAD_binding_7, FAD binding domain of DNA photolyase, score 284.8, E-value 1.2e-82 282459003250 3 probable transmembrane helices predicted for SAS0657 by TMHMM2.0 at aa 5-24, 28-47 and 68-90 282459003251 Predicted membrane protein [Function unknown]; Region: COG4330 282459003252 6 probable transmembrane helices predicted for SAS0658 by TMHMM2.0 at aa 7-29, 33-50, 57-79, 103-125, 132-154 and 177-199 282459003253 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 282459003254 trimer interface [polypeptide binding]; other site 282459003255 putative Zn binding site [ion binding]; other site 282459003256 Pfam match to entry PF03479 DUF296, Domain of unknown function (DUF296), score 142.6, E-value 7.2e-40 282459003257 Signal peptide predicted for SAS0660 by SignalP 2.0 HMM (Signal peptide probabilty 0.665) with cleavage site probability 0.651 between residues 30 and 31; signal peptide 282459003258 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 282459003259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459003260 putative substrate translocation pore; other site 282459003261 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -79.9, E-value 0.00026 282459003262 12 probable transmembrane helices predicted for SAS0660 by TMHMM2.0 at aa 7-29, 40-62, 69-91, 95-117, 129-151, 156-178, 203-225, 240-259, 266-288, 292-314, 327-349 and 353-375 282459003263 Signal peptide predicted for SAS0661 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.427 between residues 37 and 38; signal peptide 282459003264 1 probable transmembrane helix predicted for SAS0661 by TMHMM2.0 at aa 10-32 282459003265 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 282459003266 putative deacylase active site [active] 282459003267 Pfam match to entry PF04073 YbaK, YbaK / prolyl-tRNA synthetases associated domain, score 205.0, E-value 1.2e-58 282459003268 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 282459003269 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 282459003270 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 282459003271 Pfam match to entry PF00455 deoR, Bacterial regulatory proteins, deoR family, score 229.6, E-value 4.7e-66 282459003272 PS00894 Bacterial regulatory proteins, deoR family signature. 282459003273 Predicted helix-turn-helix motif for SAS0663 with score 1665.000, SD 4.86 at aa 21-42, sequence LTLQELIDRTGCSASTIRRDLS 282459003274 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 282459003275 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 282459003276 putative substrate binding site [chemical binding]; other site 282459003277 putative ATP binding site [chemical binding]; other site 282459003278 Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 166.9, E-value 3.6e-47 282459003279 PS00584 pfkB family of carbohydrate kinases signature 2. 282459003280 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 282459003281 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282459003282 active site 282459003283 phosphorylation site [posttranslational modification] 282459003284 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 282459003285 active site 282459003286 P-loop; other site 282459003287 phosphorylation site [posttranslational modification] 282459003288 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 282459003289 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 99.6, E-value 6.7e-27 282459003290 PS00372 PTS EIIA domains phosphorylation site signature 2. 282459003291 Pfam match to entry PF02379 PTS_IIB_fruc, PTS system, Fructose specific IIB subunit, score 202.2, E-value 8.4e-58 282459003292 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 141.5, E-value 1.6e-39 282459003293 9 probable transmembrane helices predicted for SAS0665 by TMHMM2.0 at aa 314-336, 356-378, 391-413, 433-455, 467-489, 512-534, 547-569, 584-606 and 613-635 282459003294 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 282459003295 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 282459003296 active site 282459003297 dimer interface [polypeptide binding]; other site 282459003298 Pfam match to entry PF01979 Amidohydro_1, Amidohydrolase family, score 66.6, E-value 5.4e-17 282459003299 Signal peptide predicted for SAS0667 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.706 between residues 28 and 29; signal peptide 282459003300 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 282459003301 Domain of unknown function DUF21; Region: DUF21; pfam01595 282459003302 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 282459003303 Transporter associated domain; Region: CorC_HlyC; pfam03471 282459003304 4 probable transmembrane helices predicted for SAS0667 by TMHMM2.0 at aa 5-27, 58-80, 100-122 and 139-161 282459003305 Pfam match to entry PF01595 DUF21, Domain of unknown function DUF21, score 312.5, E-value 5.3e-91 282459003306 Pfam match to entry PF00571 CBS, CBS domain, score 39.8, E-value 6.6e-09 282459003307 Pfam match to entry PF00571 CBS, CBS domain, score 42.5, E-value 1e-09 282459003308 Pfam match to entry PF03471 CorC_HlyC, Transporter associated domain, score 73.1, E-value 6.1e-19 282459003309 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 282459003310 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 282459003311 active site 282459003312 catalytic tetrad [active] 282459003313 Pfam match to entry PF00248 aldo_ket_red, Aldo/keto reductase family, score 411.3, E-value 9.5e-121 282459003314 PS00798 Aldo/keto reductase family signature 1. 282459003315 PS00062 Aldo/keto reductase family signature 2. 282459003316 PS00063 Aldo/keto reductase family active site signature. 282459003317 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 282459003318 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 282459003319 Ligand binding site; other site 282459003320 Putative Catalytic site; other site 282459003321 DXD motif; other site 282459003322 Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferase, score 89.7, E-value 6.2e-24 282459003323 2 probable transmembrane helices predicted for SAS0669 by TMHMM2.0 at aa 237-259 and 269-291 282459003324 Signal peptide predicted for SAS0670 by SignalP 2.0 HMM (Signal peptide probabilty 0.883) with cleavage site probability 0.657 between residues 25 and 26; signal peptide 282459003325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 282459003326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282459003327 dimer interface [polypeptide binding]; other site 282459003328 phosphorylation site [posttranslational modification] 282459003329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459003330 ATP binding site [chemical binding]; other site 282459003331 Mg2+ binding site [ion binding]; other site 282459003332 G-X-G motif; other site 282459003333 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 123.5, E-value 4.2e-34 282459003334 Pfam match to entry PF00512 HisKA, His Kinase A (phosphoacceptor) domain, score 54.8, E-value 1.9e-13 282459003335 Pfam match to entry PF00672 HAMP, HAMP domain, score 33.1, E-value 7e-07 282459003336 2 probable transmembrane helices predicted for SAS0670 by TMHMM2.0 at aa 9-31 and 41-63 282459003337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282459003338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459003339 active site 282459003340 phosphorylation site [posttranslational modification] 282459003341 intermolecular recognition site; other site 282459003342 dimerization interface [polypeptide binding]; other site 282459003343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282459003344 DNA binding site [nucleotide binding] 282459003345 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 78.3, E-value 1.6e-20 282459003346 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 123.1, E-value 5.3e-34 282459003347 DoxX; Region: DoxX; pfam07681 282459003348 3 probable transmembrane helices predicted for SAS0672 by TMHMM2.0 at aa 5-24, 75-97 and 99-121 282459003349 Signal peptide predicted for SAS0673 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.363 between residues 26 and 27; signal peptide 282459003350 Electron transfer DM13; Region: DM13; pfam10517 282459003351 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459003352 6 probable transmembrane helices predicted for SAS0674 by TMHMM2.0 at aa 4-21, 28-48, 53-72, 85-102, 112-134 and 155-188 282459003353 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 282459003354 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 282459003355 Pfam match to entry PF04055 Radical_SAM, Radical SAM superfamily, score 42.2, E-value 1.2e-09 282459003356 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 282459003357 active site 282459003358 Pfam match to entry PF01242 PTPS, 6-pyruvoyl tetrahydropterin synthase, score 24.2, E-value 3e-08 282459003359 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 282459003360 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 282459003361 Ligand Binding Site [chemical binding]; other site 282459003362 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 282459003363 Glutamine amidotransferase class-I; Region: GATase; pfam00117 282459003364 glutamine binding [chemical binding]; other site 282459003365 catalytic triad [active] 282459003366 Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I, score 214.9, E-value 1.2e-61 282459003367 PS00442 Glutamine amidotransferases class-I active site. 282459003368 aminodeoxychorismate synthase; Provisional; Region: PRK07508 282459003369 chorismate binding enzyme; Region: Chorismate_bind; cl10555 282459003370 Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme, score 187.9, E-value 1.7e-53 282459003371 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003372 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 282459003373 substrate-cofactor binding pocket; other site 282459003374 Aminotransferase class IV; Region: Aminotran_4; pfam01063 282459003375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459003376 catalytic residue [active] 282459003377 2 probable transmembrane helices predicted for SAS0681 by TMHMM2.0 at aa 2-19 and 29-51 282459003378 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 282459003379 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 282459003380 Pfam match to entry PF02682 AHS1, Allophanate hydrolase subunit 1, score 96.3, E-value 6.2e-26 282459003381 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 282459003382 Pfam match to entry PF02626 AHS2, Allophanate hydrolase subunit 2, score 162.7, E-value 6.7e-46 282459003383 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 282459003384 Signal peptide predicted for SAS0684 by SignalP 2.0 HMM (Signal peptide probabilty 0.898) with cleavage site probability 0.586 between residues 29 and 30; signal peptide 282459003385 Sulfatase; Region: Sulfatase; pfam00884 282459003386 5 probable transmembrane helices predicted for SAS0684 by TMHMM2.0 at aa 9-31, 41-63, 70-92, 122-141 and 154-173 282459003387 Pfam match to entry PF00884 Sulfatase, Sulfatase, score 86.4, E-value 6.1e-23 282459003388 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 282459003389 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282459003390 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282459003391 ABC transporter; Region: ABC_tran_2; pfam12848 282459003392 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282459003393 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 147.6, E-value 2.3e-41 282459003394 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003395 PS00211 ABC transporters family signature. 282459003396 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 147.3, E-value 2.8e-41 282459003397 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003398 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 282459003399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282459003400 ATP binding site [chemical binding]; other site 282459003401 putative Mg++ binding site [ion binding]; other site 282459003402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282459003403 nucleotide binding region [chemical binding]; other site 282459003404 ATP-binding site [chemical binding]; other site 282459003405 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 282459003406 HRDC domain; Region: HRDC; pfam00570 282459003407 Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase, score 136.2, E-value 6.1e-38 282459003408 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 106.3, E-value 6e-29 282459003409 Pfam match to entry PF00570 HRDC, HRDC domain, score 38.3, E-value 1.9e-08 282459003410 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 282459003411 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 282459003412 Walker A/P-loop; other site 282459003413 ATP binding site [chemical binding]; other site 282459003414 Q-loop/lid; other site 282459003415 ABC transporter signature motif; other site 282459003416 Walker B; other site 282459003417 D-loop; other site 282459003418 H-loop/switch region; other site 282459003419 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 211.1, E-value 1.8e-60 282459003420 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003421 PS00211 ABC transporters family signature. 282459003422 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 282459003423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459003424 dimer interface [polypeptide binding]; other site 282459003425 conserved gate region; other site 282459003426 ABC-ATPase subunit interface; other site 282459003427 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 282459003428 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 282459003429 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 108.8, E-value 1.1e-29 282459003430 6 probable transmembrane helices predicted for SAS0688 by TMHMM2.0 at aa 23-45, 52-74, 78-97, 148-170, 180-202 and 209-231 282459003431 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282459003432 Pfam match to entry PF04069 OpuAC, Substrate binding domain of ABC-type glycine betaine transport system, score 392.0, E-value 6.3e-115 282459003433 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 282459003434 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 282459003435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459003436 homodimer interface [polypeptide binding]; other site 282459003437 catalytic residue [active] 282459003438 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class I and II, score 87.1, E-value 3.8e-23 282459003439 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 282459003440 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 282459003441 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 282459003442 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 282459003443 Pfam match to entry PF00781 DAGKc, Diacylglycerol kinase catalytic domain (presumed), score 40.5, E-value 4.1e-09 282459003444 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 282459003445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459003446 putative substrate translocation pore; other site 282459003447 POT family; Region: PTR2; cl17359 282459003448 13 probable transmembrane helices predicted for SAS0692 by TMHMM2.0 at aa 40-62, 69-88, 103-136, 157-176, 186-208, 231-253, 263-280, 293-310, 341-363, 376-398, 408-430, 443-462 and 472-494 282459003449 Pfam match to entry PF00854 PTR2, POT family, score 117.3, E-value 3.1e-32 282459003450 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 282459003451 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 282459003452 Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I, score 217.3, E-value 2.3e-62 282459003453 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 282459003454 Signal peptide predicted for SAS0694 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.634 between residues 35 and 36; signal peptide 282459003455 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6, score 37.0, E-value 4.4e-08 282459003456 10 probable transmembrane helices predicted for SAS0694 by TMHMM2.0 at aa 7-29, 39-56, 68-87, 97-114, 121-136, 146-168, 175-197, 207-229, 236-254 and 259-276 282459003457 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6, score 38.4, E-value 1.8e-08 282459003458 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 282459003459 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 282459003460 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 282459003461 Class I ribonucleotide reductase; Region: RNR_I; cd01679 282459003462 active site 282459003463 dimer interface [polypeptide binding]; other site 282459003464 catalytic residues [active] 282459003465 effector binding site; other site 282459003466 R2 peptide binding site; other site 282459003467 Pfam match to entry PF00317 ribonuc_red_lg, Ribonucleotide reductase, all-alpha domain, score 95.1, E-value 1.4e-25 282459003468 Pfam match to entry PF02867 ribonuc_red_lgC, Ribonucleotide reductase, barrel domain, score 388.8, E-value 5.8e-114 282459003469 PS00089 Ribonucleotide reductase large subunit signature. 282459003470 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 282459003471 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 282459003472 dimer interface [polypeptide binding]; other site 282459003473 putative radical transfer pathway; other site 282459003474 diiron center [ion binding]; other site 282459003475 tyrosyl radical; other site 282459003476 Pfam match to entry PF00268 ribonuc_red_sm, Ribonucleotide reductase, small chain, score 91.4, E-value 1.9e-24 282459003477 1 probable transmembrane helix predicted for SAS0697 by TMHMM2.0 at aa 155-177 282459003478 Signal peptide predicted for SAS0698 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.663 between residues 29 and 30; signal peptide 282459003479 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282459003480 ABC-ATPase subunit interface; other site 282459003481 dimer interface [polypeptide binding]; other site 282459003482 putative PBP binding regions; other site 282459003483 8 probable transmembrane helices predicted for SAS0698 by TMHMM2.0 at aa 7-29, 49-71, 92-124, 137-159, 184-206, 226-248, 268-290 and 295-314 282459003484 Pfam match to entry PF01032 FecCD, FecCD transport family, score 121.2, E-value 2e-33 282459003485 Signal peptide predicted for SAS0699 by SignalP 2.0 HMM (Signal peptide probabilty 0.966) with cleavage site probability 0.314 between residues 25 and 26; signal peptide 282459003486 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282459003487 ABC-ATPase subunit interface; other site 282459003488 dimer interface [polypeptide binding]; other site 282459003489 putative PBP binding regions; other site 282459003490 Pfam match to entry PF01032 FecCD, FecCD transport family, score 152.5, E-value 7.6e-43 282459003491 9 probable transmembrane helices predicted for SAS0699 by TMHMM2.0 at aa 10-32, 44-63, 73-95, 102-124, 129-148, 179-201, 224-246, 266-285 and 295-312 282459003492 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 282459003493 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 282459003494 Walker A/P-loop; other site 282459003495 ATP binding site [chemical binding]; other site 282459003496 Q-loop/lid; other site 282459003497 ABC transporter signature motif; other site 282459003498 Walker B; other site 282459003499 D-loop; other site 282459003500 H-loop/switch region; other site 282459003501 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 177.7, E-value 2e-50 282459003502 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003503 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 282459003504 Signal peptide predicted for SAS0701 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.484 between residues 28 and 29; signal peptide 282459003505 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 282459003506 putative ligand binding residues [chemical binding]; other site 282459003507 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459003508 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 141.8, E-value 1.3e-39 282459003509 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003510 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 282459003511 CHY zinc finger; Region: zf-CHY; pfam05495 282459003512 Pfam match to entry PF05495 zf-CHY, CHY zinc finger, score 133.6, E-value 3.7e-37 282459003513 PS00190 Cytochrome c family heme-binding site signature. 282459003514 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 282459003515 FAD binding domain; Region: FAD_binding_4; pfam01565 282459003516 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 282459003517 Pfam match to entry PF02873 MurB_C, UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain, score 133.3, E-value 4.7e-37 282459003518 Pfam match to entry PF01565 FAD_binding_4, FAD binding domain, score 111.2, E-value 2e-30 282459003519 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 282459003520 Pfam match to entry PF04229 UPF0157, Uncharacterised protein family (UPF0157), score 262.4, E-value 6.5e-76 282459003521 Signal peptide predicted for SAS0705 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.491 between residues 26 and 27; signal peptide 282459003522 1 probable transmembrane helix predicted for SAS0705 by TMHMM2.0 at aa 4-21 282459003523 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459003524 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 282459003525 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 282459003526 Pfam match to entry PF02595 Gly_kinase, Glycerate kinase family, score -125.2, E-value 6.3e-08 282459003527 peptidase T; Region: peptidase-T; TIGR01882 282459003528 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 282459003529 metal binding site [ion binding]; metal-binding site 282459003530 dimer interface [polypeptide binding]; other site 282459003531 Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40, score 208.3, E-value 1.2e-59 282459003532 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 282459003533 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 282459003534 Uncharacterized conserved protein [Function unknown]; Region: COG3610 282459003535 5 probable transmembrane helices predicted for SAS0709 by TMHMM2.0 at aa 4-21, 28-45, 55-72, 79-98 and 118-140 282459003536 Uncharacterized conserved protein [Function unknown]; Region: COG2966 282459003537 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 282459003538 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 282459003539 5 probable transmembrane helices predicted for SAS0710 by TMHMM2.0 at aa 120-142, 146-163, 170-188, 198-217 and 230-252 282459003540 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 282459003541 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 282459003542 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 282459003543 metal binding site [ion binding]; metal-binding site 282459003544 active site 282459003545 I-site; other site 282459003546 Pfam match to entry PF00990 GGDEF, GGDEF domain, score 117.7, E-value 2.3e-32 282459003547 6 probable transmembrane helices predicted for SAS0711 by TMHMM2.0 at aa 5-24, 31-53, 68-90, 97-119, 124-146 and 153-175 282459003548 Signal peptide predicted for SAS0712 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.920 between residues 23 and 24; signal peptide 282459003549 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 282459003550 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 282459003551 Mg++ binding site [ion binding]; other site 282459003552 putative catalytic motif [active] 282459003553 substrate binding site [chemical binding]; other site 282459003554 10 probable transmembrane helices predicted for SAS0712 by TMHMM2.0 at aa 2-24, 44-63, 70-89, 99-121, 128-150, 165-197, 204-226, 231-253, 285-304 and 309-331 282459003555 Pfam match to entry PF00953 Glycos_transf_4, Glycosyl transferase, score 227.3, E-value 2.4e-65 282459003556 Uncharacterized conserved protein [Function unknown]; Region: COG1739 282459003557 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 282459003558 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 282459003559 Pfam match to entry PF01205 UPF0029, Uncharacterized protein family UPF0029, score 191.7, E-value 1.2e-54 282459003560 PS00910 Uncharacterized protein family UPF0029 signature. 282459003561 EDD domain protein, DegV family; Region: DegV; TIGR00762 282459003562 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 282459003563 Pfam match to entry PF02645 DUF194, Uncharacterized protein, DegV family COG1307, score 283.6, E-value 2.7e-82 282459003564 DEAD-like helicases superfamily; Region: DEXDc; smart00487 282459003565 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282459003566 ATP binding site [chemical binding]; other site 282459003567 putative Mg++ binding site [ion binding]; other site 282459003568 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282459003569 nucleotide binding region [chemical binding]; other site 282459003570 ATP-binding site [chemical binding]; other site 282459003571 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003572 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 33.4, E-value 5.4e-07 282459003573 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 282459003574 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282459003575 active site 282459003576 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 282459003577 30S subunit binding site; other site 282459003578 Pfam match to entry PF02482 Ribosomal_S30AE, Sigma 54 modulation protein / S30EA ribosomal protein, score 98.1, E-value 1.9e-26 282459003579 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 282459003580 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 282459003581 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 282459003582 nucleotide binding region [chemical binding]; other site 282459003583 ATP-binding site [chemical binding]; other site 282459003584 SEC-C motif; Region: SEC-C; pfam02810 282459003585 Pfam match to entry PF01043 SecA_protein, SecA protein, amino terminal region, score 1024.6, E-value 0 282459003586 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 12.5, E-value 0.0015 282459003587 PS01312 Protein secA signatures. 282459003588 Pfam match to entry PF02810 SEC-C, SEC-C motif, score 31.0, E-value 2.9e-06 282459003589 peptide chain release factor 2; Validated; Region: prfB; PRK00578 282459003590 This domain is found in peptide chain release factors; Region: PCRF; smart00937 282459003591 RF-1 domain; Region: RF-1; pfam00472 282459003592 Pfam match to entry PF03462 PCRF, PCRF domain, score 222.6, E-value 6.1e-64 282459003593 Pfam match to entry PF00472 RF-1, Peptidyl-tRNA hydrolase domain, score 234.7, E-value 1.4e-67 282459003594 Signal peptide predicted for SAS0720 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.952 between residues 24 and 25; signal peptide 282459003595 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 282459003596 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282459003597 Surface antigen [General function prediction only]; Region: COG3942 282459003598 CHAP domain; Region: CHAP; pfam05257 282459003599 Pfam match to entry PF01476 LysM, LysM domain, score 41.2, E-value 2.4e-09 282459003600 Pfam match to entry PF05257 CHAP, CHAP domain, score 168.8, E-value 9.8e-48 282459003601 HD domain; Region: HD_3; cl17350 282459003602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 282459003603 3 probable transmembrane helices predicted for SAS0722 by TMHMM2.0 at aa 2-21, 26-41 and 48-65 282459003604 excinuclease ABC subunit B; Provisional; Region: PRK05298 282459003605 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282459003606 ATP binding site [chemical binding]; other site 282459003607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282459003608 nucleotide binding region [chemical binding]; other site 282459003609 ATP-binding site [chemical binding]; other site 282459003610 Ultra-violet resistance protein B; Region: UvrB; pfam12344 282459003611 UvrB/uvrC motif; Region: UVR; pfam02151 282459003612 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003613 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 78.4, E-value 1.6e-20 282459003614 Pfam match to entry PF02151 UVR, UvrB/uvrC motif, score 47.6, E-value 2.8e-11 282459003615 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 282459003616 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 282459003617 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 282459003618 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 282459003619 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 11.9, E-value 5.4e-07 282459003620 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003621 PS00190 Cytochrome c family heme-binding site signature. 282459003622 PS00211 ABC transporters family signature. 282459003623 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 95.2, E-value 1.4e-25 282459003624 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003625 PS00211 ABC transporters family signature. 282459003626 HPr kinase/phosphorylase; Provisional; Region: PRK05428 282459003627 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 282459003628 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 282459003629 Hpr binding site; other site 282459003630 active site 282459003631 homohexamer subunit interaction site [polypeptide binding]; other site 282459003632 Pfam match to entry PF02603 Hpr_kinase, HPr Serine kinase, score 489.8, E-value 2.3e-144 282459003633 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003634 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 282459003635 Pfam match to entry PF01790 LGT, Prolipoprotein diacylglyceryl transferase, score 453.0, E-value 2.7e-133 282459003636 5 probable transmembrane helices predicted for SAS0726 by TMHMM2.0 at aa 20-42, 55-74, 89-111, 203-221 and 236-255 282459003637 PS01311 Prolipoprotein diacylglyceryl transferase signature. 282459003638 putative acyl transferase; Provisional; Region: PRK10191 282459003639 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 282459003640 trimer interface [polypeptide binding]; other site 282459003641 active site 282459003642 substrate binding site [chemical binding]; other site 282459003643 CoA binding site [chemical binding]; other site 282459003644 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 8.8, E-value 8.5 282459003645 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 17.5, E-value 0.034 282459003646 PS00101 Hexapeptide-repeat containing-transferases signature. 282459003647 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 13.6, E-value 0.51 282459003648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 282459003649 binding surface 282459003650 TPR motif; other site 282459003651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 282459003652 TPR motif; other site 282459003653 binding surface 282459003654 Pfam match to entry PF00515 TPR, TPR Domain, score 22.8, E-value 0.00083 282459003655 Pfam match to entry PF00515 TPR, TPR Domain, score 17.7, E-value 0.03 282459003656 Predicted helix-turn-helix motif for SAS0728 with score 976.000, SD 2.51 at aa 453-474, sequence VTKKQITTWLGITQYKLNKMIE 282459003657 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 282459003658 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 282459003659 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282459003660 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 285.7, E-value 6.3e-83 282459003661 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 282459003662 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 282459003663 Pfam match to entry PF03668 ATP_bind2, P-loop ATPase family, score 450.9, E-value 1.2e-132 282459003664 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003665 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003666 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 282459003667 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 282459003668 phosphate binding site [ion binding]; other site 282459003669 dimer interface [polypeptide binding]; other site 282459003670 Pfam match to entry PF01933 UPF0052, Uncharacterised protein family UPF0052, score 525.4, E-value 4.2e-155 282459003671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 282459003672 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 282459003673 Pfam match to entry PF02650 DUF199, Uncharacterized BCR, COG1481, score 430.1, E-value 2.1e-126 282459003674 Clp protease; Region: CLP_protease; pfam00574 282459003675 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 282459003676 oligomer interface [polypeptide binding]; other site 282459003677 active site residues [active] 282459003678 Pfam match to entry PF00574 CLP_protease, Clp protease, score 473.8, E-value 1.5e-139 282459003679 PS00381 Endopeptidase Clp serine active site. 282459003680 PS00382 Endopeptidase Clp histidine active site. 282459003681 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 282459003682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 282459003683 NAD(P) binding site [chemical binding]; other site 282459003684 active site 282459003685 Signal peptide predicted for SAS0736 by SignalP 2.0 HMM (Signal peptide probabilty 0.929) with cleavage site probability 0.846 between residues 46 and 47; signal peptide 282459003686 1 probable transmembrane helix predicted for SAS0736 by TMHMM2.0 at aa 25-47 282459003687 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 282459003688 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 282459003689 Pfam match to entry PF04198 Sugar-bind, sugar-binding domain, score 350.5, E-value 1.9e-102 282459003690 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 282459003691 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 282459003692 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 282459003693 Pfam match to entry PF00044 gpdh, Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain, score 305.5, E-value 6.9e-89 282459003694 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 282459003695 Pfam match to entry PF02800 gpdh_C, Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, score 343.3, E-value 2.9e-100 282459003696 PS00211 ABC transporters family signature. 282459003697 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 282459003698 Phosphoglycerate kinase; Region: PGK; pfam00162 282459003699 substrate binding site [chemical binding]; other site 282459003700 hinge regions; other site 282459003701 ADP binding site [chemical binding]; other site 282459003702 catalytic site [active] 282459003703 Pfam match to entry PF00162 PGK, Phosphoglycerate kinase, score 705.6, E-value 2.4e-209 282459003704 PS00111 Phosphoglycerate kinase signature. 282459003705 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 282459003706 triosephosphate isomerase; Provisional; Region: PRK14565 282459003707 substrate binding site [chemical binding]; other site 282459003708 dimer interface [polypeptide binding]; other site 282459003709 catalytic triad [active] 282459003710 Pfam match to entry PF00121 TIM, Triosephosphate isomerase, score 465.3, E-value 5.2e-137 282459003711 PS00171 Triosephosphate isomerase active site. 282459003712 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 282459003713 phosphoglyceromutase; Provisional; Region: PRK05434 282459003714 PS00687 Aldehyde dehydrogenases glutamic acid active site. 282459003715 Pfam match to entry PF01676 Metalloenzyme, Metalloenzyme superfamily, score 177.7, E-value 2e-50 282459003716 enolase; Provisional; Region: eno; PRK00077 282459003717 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 282459003718 dimer interface [polypeptide binding]; other site 282459003719 metal binding site [ion binding]; metal-binding site 282459003720 substrate binding pocket [chemical binding]; other site 282459003721 Pfam match to entry PF03952 enolase_N, Enolase, N-terminal domain, score 250.7, E-value 2.1e-72 282459003722 Pfam match to entry PF00113 enolase, Enolase, C-terminal TIM barrel domain, score 567.1, E-value 1.2e-167 282459003723 PS00164 Enolase signature. 282459003724 Signal peptide predicted for SAS0743 by SignalP 2.0 HMM (Signal peptide probabilty 0.641) with cleavage site probability 0.285 between residues 39 and 40; signal peptide 282459003725 4 probable transmembrane helices predicted for SAS0743 by TMHMM2.0 at aa 12-34, 59-81, 88-110 and 120-142 282459003726 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 282459003727 Signal peptide predicted for SAS0744 by SignalP 2.0 HMM (Signal peptide probabilty 0.787) with cleavage site probability 0.345 between residues 29 and 30; signal peptide 282459003728 Pfam match to entry PF03840 SecG, Preprotein translocase SecG subunit, score 116.6, E-value 5e-32 282459003729 2 probable transmembrane helices predicted for SAS0744 by TMHMM2.0 at aa 5-22 and 53-75 282459003730 Esterase/lipase [General function prediction only]; Region: COG1647 282459003731 ribonuclease R; Region: RNase_R; TIGR02063 282459003732 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 282459003733 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 282459003734 RNB domain; Region: RNB; pfam00773 282459003735 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 282459003736 RNA binding site [nucleotide binding]; other site 282459003737 Pfam match to entry PF00773 RNB, RNB-like protein, score 449.7, E-value 2.6e-132 282459003738 PS01175 Ribonuclease II family signature. 282459003739 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 65.4, E-value 1.3e-16 282459003740 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 282459003741 SmpB-tmRNA interface; other site 282459003742 Pfam match to entry PF01668 SmpB, SmpB protein, score 147.5, E-value 2.4e-41 282459003743 PS01317 Protein smpB signature. 282459003744 Signal peptide predicted for SAS0749 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.426 between residues 26 and 27; signal peptide 282459003745 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459003746 1 probable transmembrane helix predicted for SAS0750 by TMHMM2.0 at aa 7-29 282459003747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459003748 Coenzyme A binding pocket [chemical binding]; other site 282459003749 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 36.0, E-value 9e-08 282459003750 Signal peptide predicted for SAS0752 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.882 between residues 39 and 40; signal peptide 282459003751 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282459003752 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 282459003753 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 282459003754 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 43.4, E-value 5.4e-10 282459003755 1 probable transmembrane helix predicted for SAS0752 by TMHMM2.0 at aa 16-33 282459003756 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282459003757 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 0.7, E-value 1.1e+02 282459003758 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 1.5, E-value 77 282459003759 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 2.6, E-value 46 282459003760 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 27.9, E-value 2.5e-05 282459003761 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282459003762 Signal peptide predicted for SAS0753 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.896 between residues 26 and 27; signal peptide 282459003763 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 282459003764 Signal peptide predicted for SAS0754 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.746 between residues 26 and 27; signal peptide 282459003765 Signal peptide predicted for SAS0755 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.551 between residues 26 and 27; signal peptide 282459003766 Signal peptide predicted for SAS0756 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.366 between residues 30 and 31; signal peptide 282459003767 Staphylococcal nuclease homologues; Region: SNc; smart00318 282459003768 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 282459003769 Catalytic site; other site 282459003770 2 probable transmembrane helices predicted for SAS0756 by TMHMM2.0 at aa 5-27 and 37-59 282459003771 Pfam match to entry PF00565 SNase, Staphylococcal nuclease homologue, score 228.5, E-value 1e-65 282459003772 PS01123 Thermonuclease family signature 1. 282459003773 PS01284 Thermonuclease family signature 2. 282459003774 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 282459003775 DNA-binding site [nucleotide binding]; DNA binding site 282459003776 RNA-binding motif; other site 282459003777 Pfam match to entry PF00313 CSD, 'Cold-shock' DNA-binding domain, score 151.6, E-value 1.4e-42 282459003778 PS00352 'Cold-shock' DNA-binding domain signature. 282459003779 Signal peptide predicted for SAS0760 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.942 between residues 27 and 28; signal peptide 282459003780 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 282459003781 Signal peptide predicted for SAS0761 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.652 between residues 31 and 32; signal peptide 282459003782 2 probable transmembrane helices predicted for SAS0761 by TMHMM2.0 at aa 4-26 and 39-61 282459003783 3 probable transmembrane helices predicted for SAS0762 by TMHMM2.0 at aa 4-26, 33-55 and 60-82 282459003784 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 282459003785 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 282459003786 catalytic core [active] 282459003787 Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family, score 48.4, E-value 1.9e-13 282459003788 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 282459003789 Lysine efflux permease [General function prediction only]; Region: COG1279 282459003790 Pfam match to entry PF01810 LysE, LysE type translocator, score 138.5, E-value 1.3e-38 282459003791 6 probable transmembrane helices predicted for SAS0766 by TMHMM2.0 at aa 4-26, 38-60, 70-92, 112-134, 144-165 and 178-197 282459003792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 282459003793 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 282459003794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 282459003795 similar to hypothetical protein; Ortholog of S. aureus MRSA252 (BX571856) SAR858a; Doubtful CDS. No significant database hits 282459003796 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 282459003797 Pfam match to entry PF02566 OsmC, OsmC-like protein, score 137.8, E-value 2.1e-38 282459003798 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 282459003799 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 282459003800 active site 282459003801 catalytic residue [active] 282459003802 dimer interface [polypeptide binding]; other site 282459003803 Pfam match to entry PF01487 DHquinase_I, Type I 3-dehydroquinase, score 157.7, E-value 2.1e-44 282459003804 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 282459003805 putative FMN binding site [chemical binding]; other site 282459003806 Pfam match to entry PF00881 Nitroreductase, Nitroreductase family, score 40.0, E-value 5.6e-09 282459003807 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 282459003808 catalytic residues [active] 282459003809 Pfam match to entry PF00085 thiored, Thioredoxin, score 32.0, E-value 1.1e-08 282459003810 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 282459003811 ArsC family; Region: ArsC; pfam03960 282459003812 putative ArsC-like catalytic residues; other site 282459003813 putative TRX-like catalytic residues [active] 282459003814 Pfam match to entry PF03960 ArsC, ArsC family, score 127.8, E-value 2e-35 282459003815 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 282459003816 lipoyl attachment site [posttranslational modification]; other site 282459003817 Pfam match to entry PF01597 GCV_H, Glycine cleavage H-protein, score 232.5, E-value 6.4e-67 282459003818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 282459003819 PS00430 TonB-dependent receptor proteins signature 1. 282459003820 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 282459003821 putative active site [active] 282459003822 putative metal binding site [ion binding]; other site 282459003823 Pfam match to entry PF01751 Toprim, Toprim domain, score 47.3, E-value 3.7e-11 282459003824 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 282459003825 catalytic residues [active] 282459003826 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 282459003827 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 282459003828 Walker A/P-loop; other site 282459003829 ATP binding site [chemical binding]; other site 282459003830 Q-loop/lid; other site 282459003831 ABC transporter signature motif; other site 282459003832 Walker B; other site 282459003833 D-loop; other site 282459003834 H-loop/switch region; other site 282459003835 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 282459003836 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 235.9, E-value 5.8e-68 282459003837 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003838 PS00211 ABC transporters family signature. 282459003839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459003840 dimer interface [polypeptide binding]; other site 282459003841 conserved gate region; other site 282459003842 ABC-ATPase subunit interface; other site 282459003843 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 77.9, E-value 2.2e-20 282459003844 5 probable transmembrane helices predicted for SAS0780 by TMHMM2.0 at aa 33-55, 68-90, 100-122, 160-182 and 202-224 282459003845 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282459003846 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 282459003847 Signal peptide predicted for SAS0781 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.959 between residues 28 and 29; signal peptide 282459003848 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 282459003849 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459003850 Pfam match to entry PF03180 Lipoprotein_9, NLPA lipoprotein, score 428.0, E-value 8.9e-126 282459003851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 282459003852 Pfam match to entry PF05532 CsbD, CsbD-like, score 73.4, E-value 5e-19 282459003853 Predicted membrane protein [Function unknown]; Region: COG2035 282459003854 9 probable transmembrane helices predicted for SAS0783 by TMHMM2.0 at aa 20-39, 51-73, 83-105, 117-134, 144-166, 173-190, 195-217, 230-252 and 256-278 282459003855 Pfam match to entry PF04018 DUF368, Domain of unknown function (DUF368), score 448.2, E-value 7.3e-132 282459003856 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 282459003857 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 282459003858 Walker A/P-loop; other site 282459003859 ATP binding site [chemical binding]; other site 282459003860 Q-loop/lid; other site 282459003861 ABC transporter signature motif; other site 282459003862 Walker B; other site 282459003863 D-loop; other site 282459003864 H-loop/switch region; other site 282459003865 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 111.1, E-value 2.3e-30 282459003866 PS00017 ATP/GTP-binding site motif A (P-loop). 282459003867 PS00211 ABC transporters family signature. 282459003868 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 282459003869 FeS assembly protein SufD; Region: sufD; TIGR01981 282459003870 Pfam match to entry PF01458 UPF0051, Uncharacterized protein family (UPF0051), score 237.8, E-value 1.7e-68 282459003871 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 282459003872 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 282459003873 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282459003874 catalytic residue [active] 282459003875 Pfam match to entry PF00266 aminotran_5, Aminotransferase class-V, score 53.4, E-value 2.2e-13 282459003876 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 282459003877 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 282459003878 trimerization site [polypeptide binding]; other site 282459003879 active site 282459003880 Pfam match to entry PF01592 NifU_N, NifU-like N terminal domain, score 154.8, E-value 1.5e-43 282459003881 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 282459003882 FeS assembly protein SufB; Region: sufB; TIGR01980 282459003883 Pfam match to entry PF01458 UPF0051, Uncharacterized protein family (UPF0051), score 452.0, E-value 5.2e-133 282459003884 Signal peptide predicted for SAS0789 by SignalP 2.0 HMM (Signal peptide probabilty 0.813) with cleavage site probability 0.775 between residues 25 and 26; signal peptide 282459003885 3 probable transmembrane helices predicted for SAS0789 by TMHMM2.0 at aa 4-21, 42-71 and 86-103 282459003886 Signal peptide predicted for SAS0790 by SignalP 2.0 HMM (Signal peptide probabilty 0.980) with cleavage site probability 0.769 between residues 24 and 25; signal peptide 282459003887 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 282459003888 Domain of unknown function DUF21; Region: DUF21; pfam01595 282459003889 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 282459003890 Pfam match to entry PF01595 DUF21, Domain of unknown function DUF21, score 216.7, E-value 3.5e-62 282459003891 4 probable transmembrane helices predicted for SAS0790 by TMHMM2.0 at aa 2-24, 54-73, 80-102 and 117-139 282459003892 Pfam match to entry PF00571 CBS, CBS domain, score 22.6, E-value 0.00097 282459003893 Pfam match to entry PF00571 CBS, CBS domain, score 24.1, E-value 0.00034 282459003894 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 282459003895 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 282459003896 FMN binding site [chemical binding]; other site 282459003897 substrate binding site [chemical binding]; other site 282459003898 putative catalytic residue [active] 282459003899 Pfam match to entry PF03060 NPD, 2-nitropropane dioxygenase, score 357.0, E-value 2.1e-104 282459003900 PS00912 Dihydroorotate dehydrogenase signature 2. 282459003901 Uncharacterized conserved protein [Function unknown]; Region: COG1801 282459003902 Pfam match to entry PF01904 DUF72, Protein of unknown function DUF72, score 380.6, E-value 1.7e-111 282459003903 Signal peptide predicted for SAS0793 by SignalP 2.0 HMM (Signal peptide probabilty 0.775) with cleavage site probability 0.184 between residues 23 and 24; signal peptide 282459003904 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 282459003905 Pfam match to entry PF01925 DUF81, Domain of unknown function DUF81, score 175.9, E-value 6.8e-50 282459003906 8 probable transmembrane helices predicted for SAS0793 by TMHMM2.0 at aa 7-29, 49-71, 83-105, 110-127, 159-181, 196-218, 223-245 and 255-274 282459003907 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 282459003908 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 282459003909 active site 282459003910 metal binding site [ion binding]; metal-binding site 282459003911 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 282459003912 Pfam match to entry PF00149 Metallophos, Calcineurin-like phosphoesterase, score 50.0, E-value 5.6e-12 282459003913 lipoyl synthase; Provisional; Region: PRK05481 282459003914 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282459003915 FeS/SAM binding site; other site 282459003916 Pfam match to entry PF04055 Radical_SAM, Radical SAM superfamily, score 85.5, E-value 1.1e-22 282459003917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 282459003918 Pfam match to entry PF06265 DUF1027, Protein of unknown function (DUF1027), score 208.8, E-value 8.8e-60 282459003919 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 282459003920 Uncharacterized conserved protein [Function unknown]; Region: COG2445 282459003921 Pfam match to entry PF01934 DUF86, Protein of unknown function DUF86, score 116.5, E-value 5.1e-32 282459003922 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 282459003923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459003924 active site 282459003925 motif I; other site 282459003926 motif II; other site 282459003927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459003928 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 79.3, E-value 8.3e-21 282459003929 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 282459003930 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 282459003931 dimerization interface [polypeptide binding]; other site 282459003932 ligand binding site [chemical binding]; other site 282459003933 NADP binding site [chemical binding]; other site 282459003934 catalytic site [active] 282459003935 Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 111.4, E-value 1.8e-30 282459003936 Pfam match to entry PF02826 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 215.2, E-value 1e-61 282459003937 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 282459003938 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 282459003939 1 probable transmembrane helix predicted for SAS0801 by TMHMM2.0 at aa 15-37 282459003940 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 282459003941 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 282459003942 acyl-activating enzyme (AAE) consensus motif; other site 282459003943 AMP binding site [chemical binding]; other site 282459003944 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 345.8, E-value 4.9e-101 282459003945 PS00697 ATP-dependent DNA ligase AMP-binding site. 282459003946 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 282459003947 10 probable transmembrane helices predicted for SAS0803 by TMHMM2.0 at aa 4-26, 31-48, 58-80, 93-115, 130-147, 210-232, 247-269, 323-340, 345-364 and 377-399 282459003948 Pfam match to entry PF03062 MBOAT, MBOAT family, score 359.7, E-value 3.2e-105 282459003949 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 282459003950 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 282459003951 Signal peptide predicted for SAS0805 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.858 between residues 33 and 34; signal peptide 282459003952 DltD N-terminal region; Region: DltD_N; pfam04915 282459003953 DltD central region; Region: DltD_M; pfam04918 282459003954 DltD C-terminal region; Region: DltD_C; pfam04914 282459003955 1 probable transmembrane helix predicted for SAS0805 by TMHMM2.0 at aa 5-27 282459003956 Pfam match to entry PF04915 DltD_N, DltD N-terminal region, score 123.3, E-value 4.8e-34 282459003957 Pfam match to entry PF04918 DltD_central, DltD central region, score 287.2, E-value 2.2e-83 282459003958 Pfam match to entry PF04914 DltD_C, DltD C-terminal region, score 266.3, E-value 4.3e-77 282459003959 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 282459003960 Pfam match to entry PF01106 NifU-like, NifU-like domain, score 133.2, E-value 5e-37 282459003961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 282459003962 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 282459003963 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282459003964 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 91.2, E-value 2.1e-24 282459003965 hypothetical protein; Provisional; Region: PRK13669 282459003966 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 282459003967 Pfam match to entry PF01521 HesB-like, HesB-like domain, score 157.4, E-value 2.5e-44 282459003968 PS01152 Hypothetical hesB/yadR/yfhF family signature. 282459003969 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 282459003970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282459003971 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 84.8, E-value 1.9e-22 282459003972 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 282459003973 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 282459003974 interface (dimer of trimers) [polypeptide binding]; other site 282459003975 Substrate-binding/catalytic site; other site 282459003976 Zn-binding sites [ion binding]; other site 282459003977 Pfam match to entry PF00883 Peptidase_M17, Cytosol aminopeptidase family, catalytic domain, score 412.9, E-value 3.1e-121 282459003978 PS00631 Cytosol aminopeptidase signature. 282459003979 Signal peptide predicted for SAS0813 by SignalP 2.0 HMM (Signal peptide probabilty 0.703) with cleavage site probability 0.230 between residues 30 and 31; signal peptide 282459003980 Predicted permease [General function prediction only]; Region: COG2056 282459003981 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 282459003982 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 282459003983 12 probable transmembrane helices predicted for SAS0813 by TMHMM2.0 at aa 7-29, 58-77, 98-115, 119-141, 148-170, 190-212, 233-255, 259-277, 290-312, 332-354, 361-383 and 420-437 282459003984 Pfam match to entry PF03553 Na_H_antiporter, Na+/H+ antiporter family, score 304.8, E-value 1.1e-88 282459003985 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 282459003986 CoenzymeA binding site [chemical binding]; other site 282459003987 subunit interaction site [polypeptide binding]; other site 282459003988 PHB binding site; other site 282459003989 Pfam match to entry PF03061 4HBT, Thioesterase superfamily, score 58.4, E-value 1.6e-14 282459003990 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 282459003991 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 282459003992 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 282459003993 Signal peptide predicted for SAS0816 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.468 between residues 24 and 25; signal peptide 282459003994 Pfam match to entry PF03334 PhaG_MnhG_YufB, Na+/H+ antiporter subunit, score 198.1, E-value 1.4e-56 282459003995 3 probable transmembrane helices predicted for SAS0816 by TMHMM2.0 at aa 7-29, 44-66 and 71-90 282459003996 Signal peptide predicted for SAS0817 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.639 between residues 32 and 33; signal peptide 282459003997 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 282459003998 Pfam match to entry PF04066 MrpF_PhaF, Multiple resistance and pH regulation protein F (MrpF / PhaF), score 81.2, E-value 2.2e-21 282459003999 3 probable transmembrane helices predicted for SAS0817 by TMHMM2.0 at aa 5-27, 34-56 and 60-82 282459004000 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 282459004001 Pfam match to entry PF01899 MNHE, Na+/H+ ion antiporter subunit, score 62.9, E-value 7.1e-16 282459004002 4 probable transmembrane helices predicted for SAS0818 by TMHMM2.0 at aa 5-22, 27-45, 52-69 and 100-122 282459004003 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 282459004004 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 282459004005 14 probable transmembrane helices predicted for SAS0819 by TMHMM2.0 at aa 6-25, 32-54, 74-96, 109-126, 131-153, 165-187, 211-233, 238-260, 275-297, 304-323, 328-350, 371-393, 408-430 and 451-470 282459004006 Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 176.3, E-value 5.1e-50 282459004007 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 282459004008 Pfam match to entry PF00420 oxidored_q2, NADH-ubiquinone/plastoquinone oxidoreductase chain 4L, score 91.9, E-value 1.3e-24 282459004009 3 probable transmembrane helices predicted for SAS0820 by TMHMM2.0 at aa 4-21, 26-48 and 68-90 282459004010 Signal peptide predicted for SAS0821 by SignalP 2.0 HMM (Signal peptide probabilty 0.871) with cleavage site probability 0.457 between residues 47 and 48; signal peptide 282459004011 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 282459004012 4 probable transmembrane helices predicted for SAS0821 by TMHMM2.0 at aa 9-31, 35-57, 70-92 and 116-138 282459004013 Pfam match to entry PF04039 MnhB, Domain related to MnhB subunit of Na+/H+ antiporter, score 141.0, E-value 2.2e-39 282459004014 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 282459004015 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 282459004016 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 282459004017 21 probable transmembrane helices predicted for SAS0822 by TMHMM2.0 at aa 4-25, 30-49, 79-101, 108-127, 131-153, 166-188, 208-230, 243-265, 270-289, 302-324, 339-361, 373-395, 429-451, 472-494, 526-548, 589-611, 621-641, 646-668, 672-694, 707-729 and 767-784 282459004018 Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 226.9, E-value 3.1e-65 282459004019 Pfam match to entry PF00662 oxidored_q1_N, NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus, score 31.7, E-value 1.8e-06 282459004020 Kinase associated protein B; Region: KapB; pfam08810 282459004021 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 282459004022 active site 282459004023 Pfam match to entry PF00160 pro_isomerase, Cyclophilin type peptidyl-prolyl cis-trans isomerase, score 171.7, E-value 1.3e-48 282459004024 general stress protein 13; Validated; Region: PRK08059 282459004025 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 282459004026 RNA binding site [nucleotide binding]; other site 282459004027 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 68.3, E-value 1.7e-17 282459004028 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 282459004029 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 282459004030 putative active site [active] 282459004031 putative FMN binding site [chemical binding]; other site 282459004032 putative substrate binding site [chemical binding]; other site 282459004033 putative catalytic residue [active] 282459004034 Pfam match to entry PF00724 oxidored_FMN, NADH:flavin oxidoreductase / NADH oxidase family, score 268.3, E-value 1.1e-77 282459004035 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 282459004036 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 282459004037 inhibitor-cofactor binding pocket; inhibition site 282459004038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459004039 catalytic residue [active] 282459004040 Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III, score 633.7, E-value 1.1e-187 282459004041 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 282459004042 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 282459004043 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 282459004044 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 282459004045 NAD(P) binding site [chemical binding]; other site 282459004046 Pfam match to entry PF02812 GLFV_dehydrog_N, Glu/Leu/Phe/Val dehydrogenase, dimerisation domain, score 252.4, E-value 6.4e-73 282459004047 PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 282459004048 Pfam match to entry PF00208 GLFV_dehydrog, Glutamate/Leucine/Phenylalanine/Valine dehydrogenase, score 352.4, E-value 5e-103 282459004049 Signal peptide predicted for SAS0829 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.992 between residues 30 and 31; signal peptide 282459004050 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 282459004051 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 282459004052 active site 282459004053 catalytic site [active] 282459004054 metal binding site [ion binding]; metal-binding site 282459004055 Pfam match to entry PF03009 GDPD, Glycerophosphoryl diester phosphodiesterase family, score 206.6, E-value 4.1e-59 282459004056 argininosuccinate lyase; Provisional; Region: PRK00855 282459004057 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 282459004058 active sites [active] 282459004059 tetramer interface [polypeptide binding]; other site 282459004060 Pfam match to entry PF00206 lyase_1, Lyase, score 275.7, E-value 6.2e-80 282459004061 PS00163 Fumarate lyases signature. 282459004062 argininosuccinate synthase; Provisional; Region: PRK13820 282459004063 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 282459004064 ANP binding site [chemical binding]; other site 282459004065 Substrate Binding Site II [chemical binding]; other site 282459004066 Substrate Binding Site I [chemical binding]; other site 282459004067 Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase, score 754.4, E-value 5e-224 282459004068 PS00565 Argininosuccinate synthase signature 2. 282459004069 PS00564 Argininosuccinate synthase signature 1. 282459004070 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 282459004071 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 282459004072 active site 282459004073 dimer interface [polypeptide binding]; other site 282459004074 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 282459004075 dimer interface [polypeptide binding]; other site 282459004076 active site 282459004077 Pfam match to entry PF00342 PGI, Phosphoglucose isomerase, score 546.1, E-value 2.5e-161 282459004078 PS00765 Phosphoglucose isomerase signature 1. 282459004079 Uncharacterized conserved protein [Function unknown]; Region: COG0398 282459004080 5 probable transmembrane helices predicted for SAS0833 by TMHMM2.0 at aa 21-43, 48-70, 100-122, 132-151 and 156-178 282459004081 Signal peptide predicted for SAS0834 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.833 between residues 30 and 31; signal peptide 282459004082 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 282459004083 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 282459004084 Catalytic site [active] 282459004085 Pfam match to entry PF00461 Peptidase_S26, Signal peptidase I, score 24.4, E-value 2e-06 282459004086 1 probable transmembrane helix predicted for SAS0834 by TMHMM2.0 at aa 7-29 282459004087 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 282459004088 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 282459004089 Catalytic site [active] 282459004090 Pfam match to entry PF00461 Peptidase_S26, Signal peptidase I, score 182.7, E-value 6.3e-52 282459004091 1 probable transmembrane helix predicted for SAS0835 by TMHMM2.0 at aa 5-27 282459004092 PS00501 Signal peptidases I serine active site. 282459004093 PS00760 Signal peptidases I lysine active site. 282459004094 PS00761 Signal peptidases I signature 3. 282459004095 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 282459004096 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 282459004097 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004098 Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase, score 15.4, E-value 0.00022 282459004099 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 282459004100 Part of AAA domain; Region: AAA_19; pfam13245 282459004101 Family description; Region: UvrD_C_2; pfam13538 282459004102 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 282459004103 Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase, score 294.3, E-value 1.5e-85 282459004104 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004105 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 282459004106 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 282459004107 Pfam match to entry PF01557 FAA_hydrolase, Fumarylacetoacetate (FAA) hydrolase family, score 197.4, E-value 2.3e-56 282459004108 hypothetical protein; Provisional; Region: PRK13673 282459004109 Signal peptide predicted for SAS0839 by SignalP 2.0 HMM (Signal peptide probabilty 0.667) with cleavage site probability 0.396 between residues 26 and 27; signal peptide 282459004110 4 probable transmembrane helices predicted for SAS0839 by TMHMM2.0 at aa 5-24, 37-56, 66-88 and 100-122 282459004111 coenzyme A disulfide reductase; Provisional; Region: PRK13512 282459004112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 282459004113 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282459004114 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 282459004115 Pfam match to entry PF02852 pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 71.9, E-value 1.4e-18 282459004116 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 233.1, E-value 4.3e-67 282459004117 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 282459004118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459004119 active site 282459004120 motif I; other site 282459004121 motif II; other site 282459004122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459004123 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 19.2, E-value 0.00071 282459004124 PS01228 Hypothetical cof family signature 1. 282459004125 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 282459004126 Pfam match to entry PF01883 DUF59, Domain of unknown function DUF59, score 113.4, E-value 4.6e-31 282459004127 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 282459004128 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 282459004129 catalytic triad [active] 282459004130 catalytic triad [active] 282459004131 oxyanion hole [active] 282459004132 Pfam match to entry PF01757 Acyl_transf_3, Acyltransferase family, score 185.8, E-value 7.1e-53 282459004133 10 probable transmembrane helices predicted for SAS0844 by TMHMM2.0 at aa 19-36, 41-63, 84-103, 148-170, 177-199, 237-259, 272-294, 309-328, 335-357 and 377-399 282459004134 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 282459004135 Clp amino terminal domain; Region: Clp_N; pfam02861 282459004136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459004137 Walker A motif; other site 282459004138 ATP binding site [chemical binding]; other site 282459004139 Walker B motif; other site 282459004140 arginine finger; other site 282459004141 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 282459004142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459004143 Walker A motif; other site 282459004144 ATP binding site [chemical binding]; other site 282459004145 Walker B motif; other site 282459004146 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 282459004147 Pfam match to entry PF02861 Clp_N, Clp amino terminal domain, score 42.8, E-value 8.1e-10 282459004148 Pfam match to entry PF02861 Clp_N, Clp amino terminal domain, score 24.6, E-value 0.00025 282459004149 Pfam match to entry PF00004 AAA, ATPase family associated with various cellular activities (AAA), score 43.9, E-value 3.8e-10 282459004150 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004151 PS00870 Chaperonins clpA/B signature 1. 282459004152 Pfam match to entry PF00004 AAA, ATPase family associated with various cellular activities (AAA), score 4.8, E-value 0.00014 282459004153 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004154 PS00871 Chaperonins clpA/B signature 2. 282459004155 Transcriptional regulator [Transcription]; Region: LysR; COG0583 282459004156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 282459004157 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 282459004158 dimerization interface [polypeptide binding]; other site 282459004159 Pfam match to entry PF03466 LysR_substrate, LysR substrate binding domain, score 44.5, E-value 2.6e-10 282459004160 Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 48.2, E-value 1.9e-11 282459004161 PS00044 Bacterial regulatory proteins, lysR family signature. 282459004162 Predicted helix-turn-helix motif for SAS0846 with score 995.000, SD 2.58 at aa 16-37, sequence LNYRLASEEINLTIPSIHKQIK 282459004163 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 282459004164 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 282459004165 active site 282459004166 catalytic residues [active] 282459004167 metal binding site [ion binding]; metal-binding site 282459004168 Pfam match to entry PF00682 HMGL-like, HMGL-like, score 178.0, E-value 1.6e-50 282459004169 PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 282459004170 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 282459004171 Pfam match to entry PF01300 Sua5_yciO_yrdC, yrdC domain, score 33.1, E-value 3e-09 282459004172 11 probable transmembrane helices predicted for SAS0849 by TMHMM2.0 at aa 13-30, 35-54, 71-88, 92-111, 131-153, 157-176, 200-222, 232-254, 267-289, 314-336 and 343-362 282459004173 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 282459004174 substrate binding site [chemical binding]; other site 282459004175 Pfam match to entry PF01161 PBP, Phosphatidylethanolamine-binding protein, score 208.6, E-value 9.9e-60 282459004176 Signal peptide predicted for SAS0851 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.975 between residues 30 and 31; signal peptide 282459004177 MAP domain; Region: MAP; pfam03642 282459004178 Pfam match to entry PF03642 MAP, MAP domain, score 189.5, E-value 5.4e-54 282459004179 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 282459004180 2 probable transmembrane helices predicted for SAS0852 by TMHMM2.0 at aa 4-26 and 31-53 282459004181 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 282459004182 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 282459004183 dimer interface [polypeptide binding]; other site 282459004184 active site 282459004185 CoA binding pocket [chemical binding]; other site 282459004186 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 282459004187 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 282459004188 dimer interface [polypeptide binding]; other site 282459004189 active site 282459004190 Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase, N-terminal domain, score 290.7, E-value 1.9e-84 282459004191 Pfam match to entry PF02801 ketoacyl-synt_C, Beta-ketoacyl synthase, C-terminal domain, score 248.9, E-value 7.2e-72 282459004192 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 282459004193 3 probable transmembrane helices predicted for SAS0855 by TMHMM2.0 at aa 5-27, 34-56 and 100-122 282459004194 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 282459004195 Signal peptide predicted for SAS0856 by SignalP 2.0 HMM (Signal peptide probabilty 0.978) with cleavage site probability 0.872 between residues 42 and 43; signal peptide 282459004196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459004197 dimer interface [polypeptide binding]; other site 282459004198 conserved gate region; other site 282459004199 putative PBP binding loops; other site 282459004200 ABC-ATPase subunit interface; other site 282459004201 6 probable transmembrane helices predicted for SAS0856 by TMHMM2.0 at aa 5-27, 97-119, 132-154, 164-186, 225-247 and 275-297 282459004202 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 182.3, E-value 8.2e-52 282459004203 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 282459004204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459004205 dimer interface [polypeptide binding]; other site 282459004206 conserved gate region; other site 282459004207 putative PBP binding loops; other site 282459004208 ABC-ATPase subunit interface; other site 282459004209 6 probable transmembrane helices predicted for SAS0857 by TMHMM2.0 at aa 64-86, 156-178, 191-213, 217-236, 267-289 and 320-342 282459004210 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 146.3, E-value 5.5e-41 282459004211 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 282459004212 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282459004213 Walker A/P-loop; other site 282459004214 ATP binding site [chemical binding]; other site 282459004215 Q-loop/lid; other site 282459004216 ABC transporter signature motif; other site 282459004217 Walker B; other site 282459004218 D-loop; other site 282459004219 H-loop/switch region; other site 282459004220 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 282459004221 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 227.5, E-value 2.1e-65 282459004222 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004223 PS00211 ABC transporters family signature. 282459004224 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 282459004225 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282459004226 Walker A/P-loop; other site 282459004227 ATP binding site [chemical binding]; other site 282459004228 Q-loop/lid; other site 282459004229 ABC transporter signature motif; other site 282459004230 Walker B; other site 282459004231 D-loop; other site 282459004232 H-loop/switch region; other site 282459004233 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 282459004234 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 208.9, E-value 8.2e-60 282459004235 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004236 PS00211 ABC transporters family signature. 282459004237 Signal peptide predicted for SAS0860 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.566 between residues 22 and 23; signal peptide 282459004238 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 282459004239 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 282459004240 peptide binding site [polypeptide binding]; other site 282459004241 Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 267.2, E-value 2.3e-77 282459004242 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459004243 Signal peptide predicted for SAS0861 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.416 between residues 27 and 28; signal peptide 282459004244 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 282459004245 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 282459004246 peptide binding site [polypeptide binding]; other site 282459004247 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459004248 Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 103.6, E-value 4.1e-28 282459004249 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 282459004250 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282459004251 Walker A/P-loop; other site 282459004252 ATP binding site [chemical binding]; other site 282459004253 Q-loop/lid; other site 282459004254 ABC transporter signature motif; other site 282459004255 Walker B; other site 282459004256 D-loop; other site 282459004257 H-loop/switch region; other site 282459004258 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 282459004259 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 216.5, E-value 4.1e-62 282459004260 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004261 PS00211 ABC transporters family signature. 282459004262 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 282459004263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282459004264 Walker A/P-loop; other site 282459004265 ATP binding site [chemical binding]; other site 282459004266 Q-loop/lid; other site 282459004267 ABC transporter signature motif; other site 282459004268 Walker B; other site 282459004269 D-loop; other site 282459004270 H-loop/switch region; other site 282459004271 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 282459004272 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 185.6, E-value 8.4e-53 282459004273 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004274 PS00211 ABC transporters family signature. 282459004275 Signal peptide predicted for SAS0864 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.441 between residues 36 and 37; signal peptide 282459004276 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 282459004277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459004278 dimer interface [polypeptide binding]; other site 282459004279 conserved gate region; other site 282459004280 putative PBP binding loops; other site 282459004281 ABC-ATPase subunit interface; other site 282459004282 6 probable transmembrane helices predicted for SAS0864 by TMHMM2.0 at aa 9-31, 99-121, 134-156, 184-206, 241-263 and 291-313 282459004283 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 191.3, E-value 1.6e-54 282459004284 Signal peptide predicted for SAS0865 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.275 between residues 49 and 50; signal peptide 282459004285 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 282459004286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459004287 dimer interface [polypeptide binding]; other site 282459004288 conserved gate region; other site 282459004289 putative PBP binding loops; other site 282459004290 ABC-ATPase subunit interface; other site 282459004291 6 probable transmembrane helices predicted for SAS0865 by TMHMM2.0 at aa 21-43, 88-110, 117-139, 149-171, 202-224 and 261-283 282459004292 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 153.5, E-value 3.8e-43 282459004293 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 282459004294 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 282459004295 active site 282459004296 HIGH motif; other site 282459004297 dimer interface [polypeptide binding]; other site 282459004298 KMSKS motif; other site 282459004299 Pfam match to entry PF00579 tRNA-synt_1b, tRNA synthetases class I (W and Y), score 350.1, E-value 2.5e-102 282459004300 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282459004301 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 282459004302 ArsC family; Region: ArsC; pfam03960 282459004303 putative catalytic residues [active] 282459004304 thiol/disulfide switch; other site 282459004305 Pfam match to entry PF03960 ArsC, ArsC family, score 193.9, E-value 2.7e-55 282459004306 adaptor protein; Provisional; Region: PRK02315 282459004307 Pfam match to entry PF05389 MecA, Negative regulator of genetic competence (MecA), score 438.2, E-value 7.7e-129 282459004308 Competence protein CoiA-like family; Region: CoiA; cl11541 282459004309 Pfam match to entry PF06054 CoiA, Competence protein CoiA-like family, score 456.5, E-value 2.3e-134 282459004310 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 282459004311 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 282459004312 active site 282459004313 Zn binding site [ion binding]; other site 282459004314 Pfam match to entry PF01432 Peptidase_M3, Peptidase family M3, score 447.2, E-value 1.5e-131 282459004315 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 282459004316 Thioredoxin; Region: Thioredoxin_5; pfam13743 282459004317 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 282459004318 apolar tunnel; other site 282459004319 heme binding site [chemical binding]; other site 282459004320 dimerization interface [polypeptide binding]; other site 282459004321 Pfam match to entry PF01152 Bac_globin, Bacterial-like globin, score 89.4, E-value 7.4e-24 282459004322 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 282459004323 putative active site [active] 282459004324 putative metal binding residues [ion binding]; other site 282459004325 signature motif; other site 282459004326 putative triphosphate binding site [ion binding]; other site 282459004327 Pfam match to entry PF01928 CYTH, CYTH domain, score 168.4, E-value 1.3e-47 282459004328 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 282459004329 synthetase active site [active] 282459004330 NTP binding site [chemical binding]; other site 282459004331 metal binding site [ion binding]; metal-binding site 282459004332 Pfam match to entry PF04607 RelA_SpoT, Region found in RelA / SpoT proteins, score 202.0, E-value 9.4e-58 282459004333 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 282459004334 ATP-NAD kinase; Region: NAD_kinase; pfam01513 282459004335 Pfam match to entry PF01513 NAD_kinase, ATP-NAD kinase, score 195.3, E-value 1e-55 282459004336 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 282459004337 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 282459004338 active site 282459004339 Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase, score 135.7, E-value 8.5e-38 282459004340 PS01129 Rlu family of pseudouridine synthase signature. 282459004341 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 282459004342 MgtE intracellular N domain; Region: MgtE_N; smart00924 282459004343 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 282459004344 Divalent cation transporter; Region: MgtE; pfam01769 282459004345 Pfam match to entry PF03448 MgtE_N, MgtE intracellular domain, score 146.3, E-value 5.8e-41 282459004346 Pfam match to entry PF00571 CBS, CBS domain, score 43.9, E-value 3.7e-10 282459004347 Pfam match to entry PF00571 CBS, CBS domain, score 53.5, E-value 4.8e-13 282459004348 5 probable transmembrane helices predicted for SAS0878 by TMHMM2.0 at aa 295-312, 322-341, 369-391, 396-418 and 431-453 282459004349 Pfam match to entry PF01769 MgtE, Divalent cation transporter, score 127.9, E-value 1.9e-35 282459004350 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 282459004351 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 282459004352 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 282459004353 TrkA-N domain; Region: TrkA_N; pfam02254 282459004354 TrkA-C domain; Region: TrkA_C; pfam02080 282459004355 Pfam match to entry PF00999 Na_H_Exchanger, Sodium/hydrogen exchanger family, score 31.8, E-value 1.1e-08 282459004356 12 probable transmembrane helices predicted for SAS0879 by TMHMM2.0 at aa 4-20, 27-49, 54-76, 98-120, 130-149, 162-184, 190-212, 233-262, 277-299, 306-328, 338-355 and 368-387 282459004357 Pfam match to entry PF02254 TrkA-N, TrkA-N domain, score 15.4, E-value 6e-05 282459004358 Pfam match to entry PF02080 TrkA-C, TrkA-C domain, score 36.3, E-value 7.1e-08 282459004359 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 282459004360 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 282459004361 NAD binding site [chemical binding]; other site 282459004362 homotetramer interface [polypeptide binding]; other site 282459004363 homodimer interface [polypeptide binding]; other site 282459004364 substrate binding site [chemical binding]; other site 282459004365 active site 282459004366 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 53.1, E-value 6.5e-13 282459004367 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 282459004368 Domain of unknown function DUF20; Region: UPF0118; pfam01594 282459004369 9 probable transmembrane helices predicted for SAS0881 by TMHMM2.0 at aa 5-23, 30-52, 72-94, 155-177, 213-235, 242-261, 265-287, 299-318 and 323-345 282459004370 Pfam match to entry PF01594 UPF0118, Domain of unknown function DUF20, score 211.6, E-value 1.2e-60 282459004371 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 282459004372 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 282459004373 10 probable transmembrane helices predicted for SAS0882 by TMHMM2.0 at aa 18-36, 75-97, 143-160, 181-203, 207-229, 236-258, 296-318, 381-403, 418-440 and 447-469 282459004374 Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family, score 548.7, E-value 4.1e-162 282459004375 PS00873 Sodium:alanine symporter family signature. 282459004376 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 282459004377 Putative esterase; Region: Esterase; pfam00756 282459004378 Pfam match to entry PF00756 Esterase, esterase, score 303.0, E-value 3.7e-88 282459004379 hypothetical protein; Provisional; Region: PRK13679 282459004380 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 282459004381 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282459004382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459004383 putative substrate translocation pore; other site 282459004384 12 probable transmembrane helices predicted for SAS0885 by TMHMM2.0 at aa 13-35, 39-61, 80-99, 104-126, 139-161, 166-184, 211-233, 246-268, 275-297, 302-324, 337-359 and 369-391 282459004385 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 282459004386 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 282459004387 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 282459004388 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 282459004389 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 282459004390 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 282459004391 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 282459004392 Pfam match to entry PF01225 Mur_ligase, Mur ligase family, catalytic domain, score 281.4, E-value 1.2e-81 282459004393 Pfam match to entry PF02875 Mur_ligase_C, Mur ligase family, glutamate ligase domain, score 101.1, E-value 2.3e-27 282459004394 YueH-like protein; Region: YueH; pfam14166 282459004395 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 282459004396 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 282459004397 G1 box; other site 282459004398 putative GEF interaction site [polypeptide binding]; other site 282459004399 GTP/Mg2+ binding site [chemical binding]; other site 282459004400 Switch I region; other site 282459004401 G2 box; other site 282459004402 G3 box; other site 282459004403 Switch II region; other site 282459004404 G4 box; other site 282459004405 G5 box; other site 282459004406 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 282459004407 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu GTP binding domain, score 274.3, E-value 1.7e-79 282459004408 PS00301 GTP-binding elongation factors signature. 282459004409 Pfam match to entry PF03144 GTP_EFTU_D2, Elongation factor Tu domain 2, score 46.7, E-value 5.3e-11 282459004410 Signal peptide predicted for SAS0890 by SignalP 2.0 HMM (Signal peptide probabilty 0.660) with cleavage site probability 0.481 between residues 26 and 27; signal peptide 282459004411 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 282459004412 7 probable transmembrane helices predicted for SAS0890 by TMHMM2.0 at aa 5-27, 48-70, 74-93, 133-155, 170-192, 205-227 and 237-259 282459004413 Pfam match to entry PF03741 TerC, Integral membrane protein TerC family, score 186.4, E-value 4.9e-53 282459004414 Prophage 282459004415 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 282459004416 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 282459004417 Int/Topo IB signature motif; other site 282459004418 Pfam match to entry PF00589 Phage_integrase, Phage integrase family, score 179.3, E-value 6.4e-51 282459004419 3 probable transmembrane helices predicted for SAS0892 by TMHMM2.0 at aa 2-21, 36-58 and 71-93 282459004420 Signal peptide predicted for SAS0895 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.610 between residues 22 and 23; signal peptide 282459004421 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459004422 Domain of unknown function (DUF955); Region: DUF955; cl01076 282459004423 Pfam match to entry PF06114 DUF955, Domain of unknown function (DUF955), score 242.6, E-value 6e-70 282459004424 Predicted helix-turn-helix motif for SAS0896 with score 991.000, SD 2.56 at aa 102-123, sequence RNLYELSEYLQLSESYILEAIE 282459004425 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 282459004426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282459004427 non-specific DNA binding site [nucleotide binding]; other site 282459004428 salt bridge; other site 282459004429 sequence-specific DNA binding site [nucleotide binding]; other site 282459004430 Predicted helix-turn-helix motif for SAS0897 with score 1287.000, SD 3.57 at aa 52-73, sequence KRIQQLADYFNVPKSRITESKK 282459004431 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 52.6, E-value 9e-13 282459004432 Predicted helix-turn-helix motif for SAS0897 with score 2620.000, SD 8.11 at aa 23-44, sequence IDQRELAEAIGVSQPTVSNWIQ 282459004433 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282459004434 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 282459004435 non-specific DNA binding site [nucleotide binding]; other site 282459004436 salt bridge; other site 282459004437 sequence-specific DNA binding site [nucleotide binding]; other site 282459004438 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 39.7, E-value 6.7e-09 282459004439 Predicted helix-turn-helix motif for SAS0898 with score 2102.000, SD 6.35 at aa 19-40, sequence LKQQEVADILGVNAKTVGHWEK 282459004440 Homeodomain-like domain; Region: HTH_23; pfam13384 282459004441 Predicted helix-turn-helix motif for SAS0902 with score 2106.000, SD 6.36 at aa 26-47, sequence ATPTQIHQLFGVCRSTVYNWLK 282459004442 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 282459004443 Signal peptide predicted for SAS0903 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.694 between residues 38 and 39; signal peptide 282459004444 1 probable transmembrane helix predicted for SAS0903 by TMHMM2.0 at aa 7-29 282459004445 Ortholog of S. aureus MRSA252 (BX571856) SAR2089; Similar to Staphylococcus aureus temperate phage phiSLT orf100a SWALL:Q9B0G6 (EMBL:AB045978) (100 aa) fasta scores: E(): 4.2e-16, 51% id in 100 aa. CDS contains frameshifts after codon 86;hypothetical phage protein (pseudogene) 282459004446 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 282459004447 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 282459004448 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 282459004449 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 282459004450 active site 282459004451 DNA binding site [nucleotide binding] 282459004452 catalytic site [active] 282459004453 Pfam match to entry PF00476 DNA_pol_A, DNA polymerase family A, score -141.5, E-value 3.1e-06 282459004454 PS00447 DNA polymerase family A signature. 282459004455 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 282459004456 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 282459004457 Predicted helix-turn-helix motif for SAS0911 with score 1491.000, SD 4.27 at aa 16-37, sequence MTLREVSEKYHISPELLRYRYK 282459004458 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 282459004459 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 282459004460 Pfam match to entry PF06194 Phage_Orf51, Phage Conserved Open Reading Frame 51, score 197.8, E-value 1.7e-56 282459004461 YopX protein; Region: YopX; pfam09643 282459004462 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 282459004463 Pfam match to entry PF06260 DUF1024, Protein of unknown function (DUF1024), score 204.6, E-value 1.6e-58 282459004464 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 282459004465 active site 282459004466 homodimer interface [polypeptide binding]; other site 282459004467 dUTPase; Region: dUTPase_2; pfam08761 282459004468 metal binding site [ion binding]; metal-binding site 282459004469 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 282459004470 2 probable transmembrane helices predicted for SAS0922 by TMHMM2.0 at aa 7-26 and 36-58 282459004471 Transcriptional activator RinB; Region: RinB; pfam06116 282459004472 Pfam match to entry PF06116 RinB, Transcriptional activator RinB, score 126.1, E-value 6.6e-35 282459004473 similar to hypothetical protein; Ortholog of S. aureus MRSA252 (BX571856) SAR1526a 282459004474 1 probable transmembrane helix predicted for SAS0923a by TMHMM2.0 at aa 2-20 282459004475 Signal peptide predicted for SAS0924 by SignalP 2.0 HMM (Signal peptide probabilty 0.751) with cleavage site probability 0.573 between residues 23 and 24; signal peptide 282459004476 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 282459004477 1 probable transmembrane helix predicted for SAS0924 by TMHMM2.0 at aa 4-21 282459004478 Virulence-associated protein E; Region: VirE; pfam05272 282459004479 Pfam match to entry PF05272 VirE, Virulence-associated protein E, score 434.4, E-value 1.1e-127 282459004480 PS00268 Cecropin family signature. 282459004481 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004482 VRR-NUC domain; Region: VRR_NUC; pfam08774 282459004483 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 282459004484 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282459004485 ATP binding site [chemical binding]; other site 282459004486 putative Mg++ binding site [ion binding]; other site 282459004487 helicase superfamily c-terminal domain; Region: HELICc; smart00490 282459004488 Pfam match to entry PF00176 SNF2_N, SNF2 family N-terminal domain, score 1.7, E-value 2.2e-08 282459004489 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 282459004490 Predicted helix-turn-helix motif for SAS0929 with score 1252.000, SD 3.45 at aa 111-132, sequence LKIEQIGDACHMHRNTVTTIRK 282459004491 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 282459004492 active site 282459004493 Pfam match to entry PF01844 HNH, HNH endonuclease, score 28.3, E-value 1.9e-05 282459004494 PS00190 Cytochrome c family heme-binding site signature. 282459004495 Phage terminase, small subunit; Region: Terminase_4; pfam05119 282459004496 Pfam match to entry PF05119 Terminase_4, Phage terminase, small subunit, score 106.3, E-value 6.2e-29 282459004497 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 282459004498 Pfam match to entry PF03354 Terminase_1, Phage Terminase, score 397.0, E-value 2e-116 282459004499 Phage-related protein [Function unknown]; Region: COG4695; cl01923 282459004500 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 282459004501 Pfam match to entry PF04860 Phage_portal, Phage portal protein, score 396.9, E-value 2.1e-116 282459004502 Clp protease; Region: CLP_protease; pfam00574 282459004503 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 282459004504 oligomer interface [polypeptide binding]; other site 282459004505 active site residues [active] 282459004506 Pfam match to entry PF00574 CLP_protease, Clp protease, score 180.8, E-value 2.3e-51 282459004507 1 probable transmembrane helix predicted for SAS0934 by TMHMM2.0 at aa 82-104 282459004508 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 282459004509 Phage capsid family; Region: Phage_capsid; pfam05065 282459004510 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 282459004511 oligomerization interface [polypeptide binding]; other site 282459004512 Pfam match to entry PF05135 Phage_QLRG, Phage QLRG family, DNA packaging, score 105.5, E-value 1.1e-28 282459004513 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 282459004514 Pfam match to entry PF04630 Phage_tail, Phage major tail protein, score 340.8, E-value 1.6e-99 282459004515 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 282459004516 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 282459004517 Pfam match to entry PF02368 Big_2, Bacterial Ig-like domain (group 2), score 35.7, E-value 1.1e-07 282459004518 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 282459004519 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 282459004520 linker region; other site 282459004521 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 282459004522 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 282459004523 dimer interface [polypeptide binding]; other site 282459004524 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 282459004525 Peptidase family M23; Region: Peptidase_M23; pfam01551 282459004526 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 282459004527 N-acetyl-D-glucosamine binding site [chemical binding]; other site 282459004528 catalytic residue [active] 282459004529 Pfam match to entry PF05017 TMP, TMP repeat, score 0.1, E-value 1.6e+02 282459004530 Pfam match to entry PF05017 TMP, TMP repeat, score 0.8, E-value 1.3e+02 282459004531 Pfam match to entry PF05017 TMP, TMP repeat, score 2.6, E-value 67 282459004532 Pfam match to entry PF05017 TMP, TMP repeat, score 5.3, E-value 26 282459004533 Pfam match to entry PF05017 TMP, TMP repeat, score 5.5, E-value 24 282459004534 Pfam match to entry PF05017 TMP, TMP repeat, score 4.3, E-value 37 282459004535 Pfam match to entry PF05017 TMP, TMP repeat, score 2.3, E-value 76 282459004536 Pfam match to entry PF01551 Peptidase_M37, Peptidase family M23/M37, score 66.1, E-value 7.7e-17 282459004537 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004538 Phage tail protein; Region: Sipho_tail; pfam05709 282459004539 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 282459004540 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 282459004541 hypothetical protein; Provisional; Region: PRK05926 282459004542 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 282459004543 PS00340 Growth factor and cytokines receptors family signature 2. 282459004544 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 282459004545 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 282459004546 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 282459004547 1 probable transmembrane helix predicted for SAS0952 by TMHMM2.0 at aa 75-97 282459004548 holin, SPP1 family; Region: holin_SPP1; TIGR01592 282459004549 Pfam match to entry PF04688 Phage_holin, Phage lysis protein, holin, score 79.3, E-value 8.3e-21 282459004550 CHAP domain; Region: CHAP; pfam05257 282459004551 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 282459004552 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 282459004553 active site 282459004554 metal binding site [ion binding]; metal-binding site 282459004555 Bacterial SH3 domain homologues; Region: SH3b; smart00287 282459004556 Pfam match to entry PF05257 CHAP, CHAP domain, score 149.2, E-value 7.5e-42 282459004557 Pfam match to entry PF01520 Amidase_3, N-acetylmuramoyl-L-alanine amidase, score 73.7, E-value 4.1e-19 282459004558 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 282459004559 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 282459004560 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 282459004561 1 probable transmembrane helix predicted for SAS0955 by TMHMM2.0 at aa 405-427 282459004562 Pfam match to entry PF00089 trypsin, Trypsin, score 37.6, E-value 2.9e-08 282459004563 Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF), score 10.2, E-value 0.051 282459004564 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 282459004565 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 282459004566 10 probable transmembrane helices predicted for SAS0956 by TMHMM2.0 at aa 15-37, 50-68, 78-100, 128-150, 193-215, 228-250, 312-334, 355-377, 382-404 and 413-435 282459004567 Pfam match to entry PF02386 TrkH, Cation transport protein, score 287.6, E-value 1.6e-83 282459004568 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004569 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 282459004570 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 282459004571 active site 282459004572 metal binding site [ion binding]; metal-binding site 282459004573 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 282459004574 1 probable transmembrane helix predicted for SAS0957 by TMHMM2.0 at aa 48-70 282459004575 Pfam match to entry PF02872 5_nucleotidaseC, 5'-nucleotidase, C-terminal domain, score 94.4, E-value 2.4e-25 282459004576 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 282459004577 Pfam match to entry PF06338 ComK, ComK protein, score 432.5, E-value 4e-127 282459004578 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 282459004579 IDEAL domain; Region: IDEAL; pfam08858 282459004580 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 282459004581 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 282459004582 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 282459004583 Pfam match to entry PF03099 BPL_LipA_LipB, Biotin/lipoate A/B protein ligase family, score 127.9, E-value 2e-35 282459004584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 282459004585 CAAX protease self-immunity; Region: Abi; pfam02517 282459004586 7 probable transmembrane helices predicted for SAS0962 by TMHMM2.0 at aa 7-27, 32-50, 63-85, 105-122, 135-154, 158-175 and 182-199 282459004587 Pfam match to entry PF02517 Abi, CAAX amino terminal protease family, score 4.8, E-value 0.0041 282459004588 1 probable transmembrane helix predicted for SAS0963 by TMHMM2.0 at aa 7-29 282459004589 Signal peptide predicted for SAS0964 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.738 between residues 28 and 29; signal peptide 282459004590 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683 282459004591 Ortholog of S. aureus MRSA252 (BX571856) SAR1002; Similar to Lactococcus lactis unknown protein ll2019 SWALL:Q9CE29 (EMBL:AE006431) (660 aa) fasta scores: E(): 1.2e-10, 19.48% id in 667 aa, and to Clostridium tetani membrane spanning protein ctc02097 SWALL:Q892J9 (EMBL:AE015943) (708 aa) fasta scores: E(): 3.4e-06, 23.19% id in 638 aa. CDS contains a frameshift after codon 113. Frameshift occurs at a poly A pentamer; membrane protein (pseudogene) 282459004592 7 probable transmembrane helices predicted for SAS0965 by TMHMM2.0 at aa 6-25, 162-181, 213-235, 242-264, 551-573, 594-616 and 620-642 282459004593 PS00904 Protein prenyltransferases alpha subunit repeat signature. 282459004594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 282459004595 Signal peptide predicted for SAS0967 by SignalP 2.0 HMM (Signal peptide probabilty 0.719) with cleavage site probability 0.425 between residues 29 and 30; signal peptide 282459004596 1 probable transmembrane helix predicted for SAS0967 by TMHMM2.0 at aa 5-27 282459004597 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282459004598 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 282459004599 Walker A/P-loop; other site 282459004600 ATP binding site [chemical binding]; other site 282459004601 Q-loop/lid; other site 282459004602 ABC transporter signature motif; other site 282459004603 Walker B; other site 282459004604 D-loop; other site 282459004605 H-loop/switch region; other site 282459004606 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 162.9, E-value 5.7e-46 282459004607 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004608 PS00211 ABC transporters family signature. 282459004609 3 probable transmembrane helices predicted for SAS0969 by TMHMM2.0 at aa 20-42, 46-68 and 73-95 282459004610 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 282459004611 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 282459004612 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 282459004613 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 144.5, E-value 2e-40 282459004614 Predicted membrane protein [Function unknown]; Region: COG2259 282459004615 Pfam match to entry PF04173 DoxD, DoxD-like family, score 105.0, E-value 1.6e-28 282459004616 2 probable transmembrane helices predicted for SAS0972 by TMHMM2.0 at aa 31-53 and 58-80 282459004617 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 282459004618 Signal peptide predicted for SAS0973 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.364 between residues 25 and 26; signal peptide 282459004619 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 282459004620 siderophore binding site; other site 282459004621 1 probable transmembrane helix predicted for SAS0973 by TMHMM2.0 at aa 5-24 282459004622 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459004623 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 190.3, E-value 3.3e-54 282459004624 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 282459004625 2 probable transmembrane helices predicted for SAS0975 by TMHMM2.0 at aa 7-25 and 35-57 282459004626 Pfam match to entry PF05154 TM2, TM2 domain, score 66.3, E-value 6.6e-17 282459004627 Pertussis toxin, subunit 2 and 3, C-terminal domain; Region: Pertussis_S2S3; pfam02918 282459004628 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 282459004629 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 56.1, E-value 7.9e-14 282459004630 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 282459004631 UbiA prenyltransferase family; Region: UbiA; pfam01040 282459004632 9 probable transmembrane helices predicted for SAS0977 by TMHMM2.0 at aa 21-43, 48-70, 101-123, 127-149, 154-176, 181-203, 224-246, 250-272 and 293-310 282459004633 Pfam match to entry PF01040 UbiA, UbiA prenyltransferase family, score 104.8, E-value 1.7e-28 282459004634 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004635 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 282459004636 isochorismate synthases; Region: isochor_syn; TIGR00543 282459004637 Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme, score 184.4, E-value 2e-52 282459004638 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00017 ATP/GTP-binding site motif A (P-loop). 282459004639 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 282459004640 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 282459004641 dimer interface [polypeptide binding]; other site 282459004642 tetramer interface [polypeptide binding]; other site 282459004643 PYR/PP interface [polypeptide binding]; other site 282459004644 TPP binding site [chemical binding]; other site 282459004645 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 282459004646 TPP-binding site; other site 282459004647 Pfam match to entry PF02776 TPP_enzymes_N, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score -63.1, E-value 0.0015 282459004648 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 282459004649 PGAP1-like protein; Region: PGAP1; pfam07819 282459004650 Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold, score 91.0, E-value 2.5e-24 282459004651 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 282459004652 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 282459004653 substrate binding site [chemical binding]; other site 282459004654 oxyanion hole (OAH) forming residues; other site 282459004655 trimer interface [polypeptide binding]; other site 282459004656 Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family, score 272.1, E-value 7.4e-79 282459004657 Staphostatin B; Region: Staphostatin_B; pfam09023 282459004658 Signal peptide predicted for SAS0983 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.795 between residues 36 and 37; signal peptide 282459004659 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 282459004660 Pfam match to entry PF05543 Peptidase_C47, Staphopain peptidase C47, score 483.5, E-value 1.8e-142 282459004661 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 282459004662 1 probable transmembrane helix predicted for SAS0983 by TMHMM2.0 at aa 7-29 282459004663 Signal peptide predicted for SAS0984 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.475 between residues 34 and 35; signal peptide 282459004664 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 282459004665 Pfam match to entry PF00089 trypsin, Trypsin, score 85.0, E-value 1.6e-22 282459004666 PS00673 Serine proteases, V8 family, serine active site. 282459004667 PS00672 Serine proteases, V8 family, histidine active site. 282459004668 aminotransferase A; Validated; Region: PRK07683 282459004669 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 282459004670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459004671 homodimer interface [polypeptide binding]; other site 282459004672 catalytic residue [active] 282459004673 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class I and II, score 155.8, E-value 7.9e-44 282459004674 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 282459004675 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 282459004676 Acyltransferase family; Region: Acyl_transf_3; pfam01757 282459004677 Pfam match to entry PF01757 Acyl_transf_3, Acyltransferase family, score 208.7, E-value 9.5e-60 282459004678 10 probable transmembrane helices predicted for SAS0986 by TMHMM2.0 at aa 9-28, 38-60, 73-95, 110-129, 136-153, 157-175, 188-210, 236-255, 262-281 and 296-318 282459004679 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 282459004680 MarR family; Region: MarR; pfam01047 282459004681 Pfam match to entry PF01047 MarR, MarR family, score 104.3, E-value 2.6e-28 282459004682 Predicted helix-turn-helix motif for SAS0987 with score 1295.000, SD 3.60 at aa 46-67, sequence LSQYDLTMKISREQSIVSRWIK 282459004683 Signal peptide predicted for SAS0988 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 29 and 30; signal peptide 282459004684 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 282459004685 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 282459004686 amidase catalytic site [active] 282459004687 Zn binding residues [ion binding]; other site 282459004688 substrate binding site [chemical binding]; other site 282459004689 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 282459004690 Lysozyme subfamily 2; Region: LYZ2; smart00047 282459004691 Pfam match to entry PF01832 Amidase_4, Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase, score 232.8, E-value 5.1e-67 282459004692 Pfam match to entry PF01510 Amidase_2, N-acetylmuramoyl-L-alanine amidase, score 147.0, E-value 3.5e-41 282459004693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459004694 Coenzyme A binding pocket [chemical binding]; other site 282459004695 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 83.1, E-value 6.1e-22 282459004696 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 282459004697 Transcriptional regulator [Transcription]; Region: LytR; COG1316 282459004698 Signal peptide predicted for SAS0991 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.647 between residues 36 and 37; signal peptide 282459004699 Pfam match to entry PF03816 LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain, score 244.0, E-value 2.2e-70 282459004700 1 probable transmembrane helix predicted for SAS0991 by TMHMM2.0 at aa 7-28 282459004701 Signal peptide predicted for SAS0992 by SignalP 2.0 HMM (Signal peptide probabilty 0.976) with cleavage site probability 0.821 between residues 35 and 36; signal peptide 282459004702 Beta-lactamase; Region: Beta-lactamase; pfam00144 282459004703 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 282459004704 1 probable transmembrane helix predicted for SAS0992 by TMHMM2.0 at aa 7-26 282459004705 Pfam match to entry PF00144 beta-lactamase, Beta-lactamase, score 193.7, E-value 3e-55 282459004706 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 282459004707 Signal peptide predicted for SAS0993 by SignalP 2.0 HMM (Signal peptide probabilty 0.950) with cleavage site probability 0.754 between residues 34 and 35; signal peptide 282459004708 3 probable transmembrane helices predicted for SAS0993 by TMHMM2.0 at aa 9-31, 36-58 and 70-89 282459004709 Pfam match to entry PF03626 COX4_pro, Prokaryotic Cytochrome C oxidase subunit IV, score 138.9, E-value 9.8e-39 282459004710 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 282459004711 Subunit I/III interface [polypeptide binding]; other site 282459004712 Subunit III/IV interface [polypeptide binding]; other site 282459004713 5 probable transmembrane helices predicted for SAS0994 by TMHMM2.0 at aa 20-42, 62-84, 91-113, 133-155 and 176-198 282459004714 Pfam match to entry PF00510 COX3, Cytochrome c oxidase subunit III, score -147.5, E-value 2.8e-07 282459004715 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 282459004716 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 282459004717 D-pathway; other site 282459004718 Putative ubiquinol binding site [chemical binding]; other site 282459004719 Low-spin heme (heme b) binding site [chemical binding]; other site 282459004720 Putative water exit pathway; other site 282459004721 Binuclear center (heme o3/CuB) [ion binding]; other site 282459004722 K-pathway; other site 282459004723 Putative proton exit pathway; other site 282459004724 15 probable transmembrane helices predicted for SAS0995 by TMHMM2.0 at aa 15-37, 56-78, 101-123, 136-158, 186-208, 228-250, 275-297, 310-332, 342-364, 377-399, 414-436, 449-471, 486-508, 587-604 and 608-627 282459004725 Pfam match to entry PF00115 COX1, Cytochrome C and Quinol oxidase polypeptide I, score 831.6, E-value 2.9e-247 282459004726 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 282459004727 Signal peptide predicted for SAS0996 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.499 between residues 28 and 29; signal peptide 282459004728 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 282459004729 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 282459004730 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 282459004731 3 probable transmembrane helices predicted for SAS0996 by TMHMM2.0 at aa 7-26, 41-63 and 84-106 282459004732 Pfam match to entry PF02790 COX2_TM, Cytochrome C oxidase subunit II, transmembrane domain, score 6.6, E-value 5.3e-05 282459004733 Signal peptide predicted for SAS0997 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.515 between residues 24 and 25; signal peptide 282459004734 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 282459004735 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 282459004736 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 282459004737 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 282459004738 homodimer interface [polypeptide binding]; other site 282459004739 NADP binding site [chemical binding]; other site 282459004740 substrate binding site [chemical binding]; other site 282459004741 Pfam match to entry PF02882 THF_DHG_CYH_C, Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain, score 291.8, E-value 9e-85 282459004742 Pfam match to entry PF00763 THF_DHG_CYH, Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain, score 204.7, E-value 1.5e-58 282459004743 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 282459004744 Pfam match to entry PF00731 AIRC, AIR carboxylase, score 301.8, E-value 8.6e-88 282459004745 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 282459004746 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 282459004747 NAD binding site [chemical binding]; other site 282459004748 ATP-grasp domain; Region: ATP-grasp; pfam02222 282459004749 Pfam match to entry PF02222 ATP-grasp, ATP-grasp domain, score 78.5, E-value 1.5e-20 282459004750 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 282459004751 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 282459004752 ATP binding site [chemical binding]; other site 282459004753 active site 282459004754 substrate binding site [chemical binding]; other site 282459004755 Pfam match to entry PF01259 SAICAR_synt, SAICAR synthetase, score 316.4, E-value 3.5e-92 282459004756 PS01058 SAICAR synthetase signature 2. 282459004757 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 282459004758 Pfam match to entry PF02700 PurC, Phosphoribosylformylglycinamidine (FGAM) synthase, score 64.7, E-value 2e-16 282459004759 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 282459004760 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 282459004761 putative active site [active] 282459004762 catalytic triad [active] 282459004763 Pfam match to entry PF01965 DJ-1_PfpI, DJ-1/PfpI family, score -3.3, E-value 0.0012 282459004764 PS00442 Glutamine amidotransferases class-I active site. 282459004765 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 282459004766 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 282459004767 dimerization interface [polypeptide binding]; other site 282459004768 ATP binding site [chemical binding]; other site 282459004769 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 282459004770 dimerization interface [polypeptide binding]; other site 282459004771 ATP binding site [chemical binding]; other site 282459004772 Pfam match to entry PF00586 AIRS, AIR synthase related protein, N-terminal domain, score 170.3, E-value 3.5e-48 282459004773 Pfam match to entry PF02769 AIRS_C, AIR synthase related protein, C-terminal domain, score 172.0, E-value 1e-48 282459004774 Pfam match to entry PF00586 AIRS, AIR synthase related protein, N-terminal domain, score 130.4, E-value 3.5e-36 282459004775 Pfam match to entry PF02769 AIRS_C, AIR synthase related protein, C-terminal domain, score 17.0, E-value 0.00076 282459004776 amidophosphoribosyltransferase; Provisional; Region: PRK07272 282459004777 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 282459004778 active site 282459004779 tetramer interface [polypeptide binding]; other site 282459004780 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282459004781 active site 282459004782 PS00443 Glutamine amidotransferases class-II active site. 282459004783 Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II, score 134.2, E-value 2.6e-37 282459004784 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 58.4, E-value 1.6e-14 282459004785 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 282459004786 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 282459004787 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 282459004788 dimerization interface [polypeptide binding]; other site 282459004789 putative ATP binding site [chemical binding]; other site 282459004790 Pfam match to entry PF00586 AIRS, AIR synthase related protein, N-terminal domain, score 226.6, E-value 3.8e-65 282459004791 Pfam match to entry PF02769 AIRS_C, AIR synthase related protein, C-terminal domain, score 175.6, E-value 8.7e-50 282459004792 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 282459004793 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 282459004794 active site 282459004795 substrate binding site [chemical binding]; other site 282459004796 cosubstrate binding site; other site 282459004797 catalytic site [active] 282459004798 Pfam match to entry PF00551 formyl_transf, Formyl transferase, score 219.7, E-value 4.5e-63 282459004799 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 282459004800 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 282459004801 purine monophosphate binding site [chemical binding]; other site 282459004802 dimer interface [polypeptide binding]; other site 282459004803 putative catalytic residues [active] 282459004804 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 282459004805 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 282459004806 Pfam match to entry PF02142 MGS, MGS-like domain, score 183.1, E-value 4.8e-52 282459004807 Pfam match to entry PF01808 AICARFT_IMPCHas, AICARFT/IMPCHase bienzyme, score 418.8, E-value 5.2e-123 282459004808 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 282459004809 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 282459004810 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 282459004811 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 282459004812 Pfam match to entry PF02844 GARS_N, Phosphoribosylglycinamide synthetase, N domain, score 153.4, E-value 4e-43 282459004813 Pfam match to entry PF02842 GARS_B, Phosphoribosylglycinamide synthetase, B domain, score 94.6, E-value 2.1e-25 282459004814 Pfam match to entry PF01071 GARS, Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain, score 221.3, E-value 1.5e-63 282459004815 PS00184 Phosphoribosylglycinamide synthetase signature. 282459004816 Pfam match to entry PF02843 GARS_C, Phosphoribosylglycinamide synthetase, C domain, score 89.3, E-value 7.9e-24 282459004817 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 282459004818 6 probable transmembrane helices predicted for SAS1011 by TMHMM2.0 at aa 20-39, 44-61, 66-88, 119-141, 153-172 and 239-261 282459004819 Pfam match to entry PF02361 CbiQ, Cobalt transport protein, score 61.4, E-value 2.1e-15 282459004820 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 282459004821 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 282459004822 Walker A/P-loop; other site 282459004823 ATP binding site [chemical binding]; other site 282459004824 Q-loop/lid; other site 282459004825 ABC transporter signature motif; other site 282459004826 Walker B; other site 282459004827 D-loop; other site 282459004828 H-loop/switch region; other site 282459004829 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 282459004830 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 282459004831 Walker A/P-loop; other site 282459004832 ATP binding site [chemical binding]; other site 282459004833 Q-loop/lid; other site 282459004834 ABC transporter signature motif; other site 282459004835 Walker B; other site 282459004836 D-loop; other site 282459004837 H-loop/switch region; other site 282459004838 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 132.8, E-value 6.8e-37 282459004839 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004840 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004841 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 120.2, E-value 4e-33 282459004842 PS00211 ABC transporters family signature. 282459004843 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004844 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 282459004845 Signal peptide predicted for SAS1013 by SignalP 2.0 HMM (Signal peptide probabilty 0.747) with cleavage site probability 0.540 between residues 36 and 37; signal peptide 282459004846 5 probable transmembrane helices predicted for SAS1013 by TMHMM2.0 at aa 10-31, 47-69, 84-106, 113-135 and 145-167 282459004847 10 probable transmembrane helices predicted for SAS1015 by TMHMM2.0 at aa 12-34, 69-91, 104-123, 128-147, 160-182, 192-214, 309-326, 346-368, 375-397 and 401-423 282459004848 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 282459004849 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 282459004850 putative RNA binding site [nucleotide binding]; other site 282459004851 Methyltransferase domain; Region: Methyltransf_26; pfam13659 282459004852 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 282459004853 dimerization domain swap beta strand [polypeptide binding]; other site 282459004854 regulatory protein interface [polypeptide binding]; other site 282459004855 active site 282459004856 regulatory phosphorylation site [posttranslational modification]; other site 282459004857 Pfam match to entry PF00381 PTS-HPr, PTS HPr component phosphorylation site, score 193.1, E-value 4.7e-55 282459004858 PS00369 PTS HPR component histidine phosphorylation site signature. 282459004859 PS00589 PTS HPR component serine phosphorylation site signature. 282459004860 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 282459004861 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 282459004862 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 282459004863 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 282459004864 Pfam match to entry PF05524 PEP-utilisers_N, PEP-utilising enzyme, N-terminal, score 221.4, E-value 1.4e-63 282459004865 Pfam match to entry PF00391 PEP-utilizers, PEP-utilising enzyme, mobile domain, score 147.4, E-value 2.7e-41 282459004866 PS00370 PEP-utilizing enzymes phosphorylation site signature. 282459004867 Pfam match to entry PF02896 PEP-utilizers_C, PEP-utilising enzyme, TIM barrel domain, score 647.1, E-value 1e-191 282459004868 PS00742 PEP-utilizing enzymes signature 2. 282459004869 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 282459004870 catalytic residues [active] 282459004871 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 282459004872 Pfam match to entry PF01654 Bac_Ubq_Cox, Bacterial Cytochrome Ubiquinol Oxidase, score 381.7, E-value 7.6e-112 282459004873 9 probable transmembrane helices predicted for SAS1021 by TMHMM2.0 at aa 15-37, 58-80, 90-112, 124-146, 182-204, 225-242, 322-344, 357-379 and 405-427 282459004874 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 282459004875 9 probable transmembrane helices predicted for SAS1022 by TMHMM2.0 at aa 10-32, 52-74, 84-103, 116-138, 158-180, 201-223, 233-255, 260-279 and 306-328 282459004876 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 282459004877 TrkA-N domain; Region: TrkA_N; pfam02254 282459004878 TrkA-C domain; Region: TrkA_C; pfam02080 282459004879 Pfam match to entry PF02254 TrkA-N, TrkA-N domain, score 163.6, E-value 3.6e-46 282459004880 Pfam match to entry PF02080 TrkA-C, TrkA-C domain, score 78.9, E-value 1.1e-20 282459004881 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 282459004882 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 282459004883 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 282459004884 PS00018 EF-hand calcium-binding domain. 282459004885 PS01292 Uncharacterized protein family UPF0036 signature. 282459004886 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 104.1, E-value 2.8e-28 282459004887 PS00136 Serine proteases, subtilase family, aspartic acid active site. 282459004888 hypothetical protein; Provisional; Region: PRK13667 282459004889 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 282459004890 active site 282459004891 catalytic residues [active] 282459004892 metal binding site [ion binding]; metal-binding site 282459004893 Pfam match to entry PF01327 Pep_deformylase, Polypeptide deformylase, score 277.2, E-value 2.2e-80 282459004894 Signal peptide predicted for SAS1027 by SignalP 2.0 HMM (Signal peptide probabilty 0.955) with cleavage site probability 0.374 between residues 25 and 26; signal peptide 282459004895 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 282459004896 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459004897 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 282459004898 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 282459004899 TPP-binding site [chemical binding]; other site 282459004900 tetramer interface [polypeptide binding]; other site 282459004901 heterodimer interface [polypeptide binding]; other site 282459004902 phosphorylation loop region [posttranslational modification] 282459004903 Pfam match to entry PF00676 E1_dehydrog, Dehydrogenase E1 component, score 490.2, E-value 1.7e-144 282459004904 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 282459004905 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 282459004906 alpha subunit interface [polypeptide binding]; other site 282459004907 TPP binding site [chemical binding]; other site 282459004908 heterodimer interface [polypeptide binding]; other site 282459004909 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 282459004910 Pfam match to entry PF02779 transket_pyr, Transketolase, pyridine binding domain, score 207.2, E-value 2.6e-59 282459004911 Pfam match to entry PF02780 transketolase_C, Transketolase, C-terminal domain, score 190.1, E-value 3.6e-54 282459004912 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 282459004913 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 282459004914 E3 interaction surface; other site 282459004915 lipoyl attachment site [posttranslational modification]; other site 282459004916 e3 binding domain; Region: E3_binding; pfam02817 282459004917 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 282459004918 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme, score 117.6, E-value 2.5e-32 282459004919 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 282459004920 Pfam match to entry PF02817 e3_binding, e3 binding domain, score 73.6, E-value 4.5e-19 282459004921 Pfam match to entry PF00198 2-oxoacid_dh, 2-oxoacid dehydrogenases acyltransferase (catalytic domain), score 464.2, E-value 1.1e-136 282459004922 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 282459004923 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 282459004924 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282459004925 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 282459004926 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 348.9, E-value 5.8e-102 282459004927 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 282459004928 Pfam match to entry PF02852 pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 185.8, E-value 7.5e-53 282459004929 hypothetical protein; Provisional; Region: PRK04387 282459004930 Pfam match to entry PF05256 UPF0223, Uncharacterised protein family (UPF0223), score 230.9, E-value 2e-66 282459004931 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 282459004932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282459004933 non-specific DNA binding site [nucleotide binding]; other site 282459004934 salt bridge; other site 282459004935 sequence-specific DNA binding site [nucleotide binding]; other site 282459004936 Cupin domain; Region: Cupin_2; pfam07883 282459004937 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 65.1, E-value 1.5e-16 282459004938 Predicted helix-turn-helix motif for SAS1033 with score 1972.000, SD 5.90 at aa 16-37, sequence LTQEELAERTDLSKGYISQIES 282459004939 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 282459004940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282459004941 Walker A/P-loop; other site 282459004942 ATP binding site [chemical binding]; other site 282459004943 Q-loop/lid; other site 282459004944 ABC transporter signature motif; other site 282459004945 Walker B; other site 282459004946 D-loop; other site 282459004947 H-loop/switch region; other site 282459004948 TOBE domain; Region: TOBE_2; pfam08402 282459004949 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 209.1, E-value 6.9e-60 282459004950 PS00017 ATP/GTP-binding site motif A (P-loop). 282459004951 PS00211 ABC transporters family signature. 282459004952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459004953 putative PBP binding loops; other site 282459004954 dimer interface [polypeptide binding]; other site 282459004955 ABC-ATPase subunit interface; other site 282459004956 6 probable transmembrane helices predicted for SAS1035 by TMHMM2.0 at aa 7-29, 60-82, 89-111, 131-153, 193-215 and 235-257 282459004957 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 9.4, E-value 0.0016 282459004958 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282459004959 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 282459004960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459004961 dimer interface [polypeptide binding]; other site 282459004962 conserved gate region; other site 282459004963 putative PBP binding loops; other site 282459004964 ABC-ATPase subunit interface; other site 282459004965 6 probable transmembrane helices predicted for SAS1036 by TMHMM2.0 at aa 7-29, 62-84, 97-119, 129-151, 175-197 and 236-258 282459004966 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 60.6, E-value 3.7e-15 282459004967 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 282459004968 Signal peptide predicted for SAS1037 by SignalP 2.0 HMM (Signal peptide probabilty 0.945) with cleavage site probability 0.584 between residues 31 and 32; signal peptide 282459004969 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 282459004970 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 282459004971 1 probable transmembrane helix predicted for SAS1037 by TMHMM2.0 at aa 7-25 282459004972 Pfam match to entry PF01547 SBP_bac_1, Bacterial extracellular solute-binding protein, score 53.9, E-value 3.7e-13 282459004973 Signal peptide predicted for SAS1038 by SignalP 2.0 HMM (Signal peptide probabilty 0.921) with cleavage site probability 0.603 between residues 45 and 46; signal peptide 282459004974 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 282459004975 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 282459004976 3 probable transmembrane helices predicted for SAS1038 by TMHMM2.0 at aa 20-42, 84-106 and 113-147 282459004977 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 282459004978 3 probable transmembrane helices predicted for SAS1039 by TMHMM2.0 at aa 7-29, 61-83 and 90-121 282459004979 manganese transport protein MntH; Reviewed; Region: PRK00701 282459004980 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 282459004981 10 probable transmembrane helices predicted for SAS1040 by TMHMM2.0 at aa 33-55, 59-81, 102-124, 139-161, 168-190, 210-232, 263-285, 305-327, 384-406 and 421-443 282459004982 Pfam match to entry PF01566 Nramp, Natural resistance-associated macrophage protein, score 485.3, E-value 4.9e-143 282459004983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 282459004984 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 282459004985 Pfam match to entry PF06335 DUF1054, Protein of unknown function (DUF1054), score 510.1, E-value 1.8e-150 282459004986 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 282459004987 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 282459004988 active site 282459004989 Pfam match to entry PF00459 inositol_P, Inositol monophosphatase family, score 221.2, E-value 1.6e-63 282459004990 PS00629 Inositol monophosphatase family signature 1. 282459004991 Signal peptide predicted for SAS1043 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.840 between residues 30 and 31; signal peptide 282459004992 2 probable transmembrane helices predicted for SAS1043 by TMHMM2.0 at aa 9-31 and 35-52 282459004993 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 282459004994 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 282459004995 G1 box; other site 282459004996 putative GEF interaction site [polypeptide binding]; other site 282459004997 GTP/Mg2+ binding site [chemical binding]; other site 282459004998 Switch I region; other site 282459004999 G2 box; other site 282459005000 G3 box; other site 282459005001 Switch II region; other site 282459005002 G4 box; other site 282459005003 G5 box; other site 282459005004 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 282459005005 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 282459005006 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu GTP binding domain, score 246.7, E-value 3.3e-71 282459005007 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005008 PS00301 GTP-binding elongation factors signature. 282459005009 Pfam match to entry PF03144 GTP_EFTU_D2, Elongation factor Tu domain 2, score 60.1, E-value 4.9e-15 282459005010 Pfam match to entry PF00679 EFG_C, Elongation factor G C-terminus, score 114.2, E-value 2.7e-31 282459005011 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 282459005012 hypothetical protein; Provisional; Region: PRK13666 282459005013 Signal peptide predicted for SAS1048 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.860 between residues 45 and 46; signal peptide 282459005014 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 282459005015 Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein, score 321.2, E-value 1.3e-93 282459005016 10 probable transmembrane helices predicted for SAS1048 by TMHMM2.0 at aa 20-42, 66-88, 93-111, 126-148, 160-177, 181-203, 208-230, 288-313, 326-348 and 363-385 282459005017 pyruvate carboxylase; Reviewed; Region: PRK12999 282459005018 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 282459005019 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 282459005020 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 282459005021 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 282459005022 active site 282459005023 catalytic residues [active] 282459005024 metal binding site [ion binding]; metal-binding site 282459005025 homodimer binding site [polypeptide binding]; other site 282459005026 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 282459005027 carboxyltransferase (CT) interaction site; other site 282459005028 biotinylation site [posttranslational modification]; other site 282459005029 Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase L chain, N-terminal domain, score 133.7, E-value 3.6e-37 282459005030 Pfam match to entry PF02786 CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain, score 354.4, E-value 1.3e-103 282459005031 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 282459005032 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 282459005033 Pfam match to entry PF02785 Biotin_carb_C, Biotin carboxylase C-terminal domain, score 201.9, E-value 1.1e-57 282459005034 Pfam match to entry PF00682 HMGL-like, HMGL-like, score 120.9, E-value 2.5e-33 282459005035 Pfam match to entry PF02436 PYC_OADA, Conserved carboxylase domain, score 331.0, E-value 1.4e-96 282459005036 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme, score 89.0, E-value 9.8e-24 282459005037 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 282459005038 Signal peptide predicted for SAS1050 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.739 between residues 34 and 35; signal peptide 282459005039 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 282459005040 Pfam match to entry PF02628 COX15-CtaA, Cytochrome oxidase assembly protein, score 138.4, E-value 1.3e-38 282459005041 8 probable transmembrane helices predicted for SAS1050 by TMHMM2.0 at aa 7-29, 65-87, 94-116, 121-143, 164-181, 211-233, 246-268 and 272-294 282459005042 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 282459005043 UbiA prenyltransferase family; Region: UbiA; pfam01040 282459005044 8 probable transmembrane helices predicted for SAS1051 by TMHMM2.0 at aa 22-44, 54-76, 104-123, 127-144, 149-171, 175-197, 227-260 and 280-302 282459005045 Pfam match to entry PF01040 UbiA, UbiA prenyltransferase family, score 239.5, E-value 4.9e-69 282459005046 Predicted membrane protein [Function unknown]; Region: COG2322 282459005047 Pfam match to entry PF04238 DUF420, Protein of unknown function (DUF420), score 259.1, E-value 6.5e-75 282459005048 4 probable transmembrane helices predicted for SAS1052 by TMHMM2.0 at aa 5-27, 39-61, 76-98 and 118-140 282459005049 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 282459005050 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 282459005051 1 probable transmembrane helix predicted for SAS1053 by TMHMM2.0 at aa 5-24 282459005052 Pfam match to entry PF00188 SCP, SCP-like extracellular protein, score 28.8, E-value 7.5e-06 282459005053 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 282459005054 Signal peptide predicted for SAS1055 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.501 between residues 30 and 31; signal peptide 282459005055 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 282459005056 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 282459005057 putative active site [active] 282459005058 catalytic site [active] 282459005059 putative metal binding site [ion binding]; other site 282459005060 Pfam match to entry PF03009 GDPD, Glycerophosphoryl diester phosphodiesterase family, score 118.8, E-value 1.1e-32 282459005061 1 probable transmembrane helix predicted for SAS1055 by TMHMM2.0 at aa 7-25 282459005062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 282459005063 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 282459005064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459005065 S-adenosylmethionine binding site [chemical binding]; other site 282459005066 Pfam match to entry PF03602 Cons_hypoth95, Conserved hypothetical protein 95, score 289.0, E-value 6e-84 282459005067 PS00092 N-6 Adenine-specific DNA methylases signature. 282459005068 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 282459005069 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 282459005070 active site 282459005071 (T/H)XGH motif; other site 282459005072 Pfam match to entry PF01467 CTP_transf_2, Cytidylyltransferase, score 123.2, E-value 5.1e-34 282459005073 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 282459005074 hypothetical protein; Provisional; Region: PRK13670 282459005075 Pfam match to entry PF05636 DUF795, Protein of unknown function (DUF795), score 788.9, E-value 2e-234 282459005076 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 282459005077 Pfam match to entry PF02620 DUF177, Uncharacterized ACR, COG1399, score 183.8, E-value 2.8e-52 282459005078 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 282459005079 Pfam match to entry PF01783 Ribosomal_L32p, Ribosomal L32p protein family, score 54.1, E-value 3.1e-13 282459005080 heme uptake protein IsdB; Region: IsdB; TIGR03657 282459005081 Signal peptide predicted for SAS1063 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.743 between residues 40 and 41; signal peptide 282459005082 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282459005083 NEAr Transporter domain; Region: NEAT; smart00725 282459005084 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 282459005085 heme-binding site [chemical binding]; other site 282459005086 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 282459005087 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 40.1, E-value 5.1e-09 282459005088 1 probable transmembrane helix predicted for SAS1063 by TMHMM2.0 at aa 622-639 282459005089 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282459005090 Pfam match to entry PF05031 NEAT, Iron Transport-associated domain, score 180.4, E-value 3.1e-51 282459005091 Pfam match to entry PF05031 NEAT, Iron Transport-associated domain, score 170.2, E-value 3.6e-48 282459005092 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 41.6, E-value 1.8e-09 282459005093 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 282459005094 Signal peptide predicted for SAS1064 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.659 between residues 46 and 47; signal peptide 282459005095 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 282459005096 heme-binding site [chemical binding]; other site 282459005097 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 40.3, E-value 4.5e-09 282459005098 1 probable transmembrane helix predicted for SAS1064 by TMHMM2.0 at aa 325-344 282459005099 Pfam match to entry PF05031 NEAT, Iron Transport-associated domain, score 197.9, E-value 1.6e-56 282459005100 heme uptake protein IsdC; Region: IsdC; TIGR03656 282459005101 Signal peptide predicted for SAS1065 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.975 between residues 28 and 29; signal peptide 282459005102 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 282459005103 heme-binding site [chemical binding]; other site 282459005104 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 282459005105 2 probable transmembrane helices predicted for SAS1065 by TMHMM2.0 at aa 7-29 and 196-218 282459005106 Pfam match to entry PF05031 NEAT, Iron Transport-associated domain, score 181.5, E-value 1.4e-51 282459005107 Signal peptide predicted for SAS1066 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.978 between residues 32 and 33; signal peptide 282459005108 2 probable transmembrane helices predicted for SAS1066 by TMHMM2.0 at aa 13-32 and 329-351 282459005109 Signal peptide predicted for SAS1067 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.699 between residues 27 and 28; signal peptide 282459005110 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 282459005111 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 282459005112 intersubunit interface [polypeptide binding]; other site 282459005113 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459005114 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 109.9, E-value 5e-30 282459005115 Signal peptide predicted for SAS1068 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.384 between residues 29 and 30; signal peptide 282459005116 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 282459005117 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282459005118 ABC-ATPase subunit interface; other site 282459005119 dimer interface [polypeptide binding]; other site 282459005120 putative PBP binding regions; other site 282459005121 8 probable transmembrane helices predicted for SAS1068 by TMHMM2.0 at aa 9-31, 60-82, 112-134, 138-160, 180-202, 230-252, 264-286 and 296-315 282459005122 Pfam match to entry PF01032 FecCD, FecCD transport family, score 239.7, E-value 4.2e-69 282459005123 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 282459005124 active site 282459005125 catalytic site [active] 282459005126 1 probable transmembrane helix predicted for SAS1069 by TMHMM2.0 at aa 7-29 282459005127 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 282459005128 Pfam match to entry PF03992 ABM, Antibiotic biosynthesis monooxygenase, score 40.7, E-value 3.4e-09 282459005129 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 282459005130 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 282459005131 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 282459005132 Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family, score 106.2, E-value 6.8e-29 282459005133 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 282459005134 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 282459005135 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 282459005136 dimer interface [polypeptide binding]; other site 282459005137 motif 1; other site 282459005138 active site 282459005139 motif 2; other site 282459005140 motif 3; other site 282459005141 Pfam match to entry PF02912 Phe_tRNA-synt_N, Aminoacyl tRNA synthetase class II, N-terminal domain, score 78.7, E-value 1.3e-20 282459005142 Pfam match to entry PF01409 tRNA-synt_2d, tRNA synthetases class II core domain (F), score 518.6, E-value 4.9e-153 282459005143 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 282459005144 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 282459005145 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 282459005146 putative tRNA-binding site [nucleotide binding]; other site 282459005147 B3/4 domain; Region: B3_4; pfam03483 282459005148 tRNA synthetase B5 domain; Region: B5; smart00874 282459005149 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 282459005150 dimer interface [polypeptide binding]; other site 282459005151 motif 1; other site 282459005152 motif 3; other site 282459005153 motif 2; other site 282459005154 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 282459005155 Pfam match to entry PF01588 tRNA_bind, tRNA binding domain, score 104.6, E-value 2e-28 282459005156 Pfam match to entry PF03483 B3_4, B3/4 domain, score 279.2, E-value 5.7e-81 282459005157 Pfam match to entry PF03484 B5, tRNA synthetase B5 domain, score 105.7, E-value 9.2e-29 282459005158 Pfam match to entry PF03147 FDX-ACB, Ferredoxin-fold anticodon binding domain, score 104.6, E-value 2e-28 282459005159 ribonuclease HIII; Provisional; Region: PRK00996 282459005160 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 282459005161 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 282459005162 RNA/DNA hybrid binding site [nucleotide binding]; other site 282459005163 active site 282459005164 Pfam match to entry PF01351 RNase_HII, Ribonuclease HII, score 158.7, E-value 1.1e-44 282459005165 Cell division protein ZapA; Region: ZapA; cl01146 282459005166 Pfam match to entry PF05164 DUF710, Family of unknown function (DUF710), score 103.2, E-value 5.3e-28 282459005167 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 282459005168 Colicin V production protein; Region: Colicin_V; pfam02674 282459005169 Pfam match to entry PF02674 Colicin_V, Colicin V production protein, score 218.8, E-value 8.5e-63 282459005170 4 probable transmembrane helices predicted for SAS1076 by TMHMM2.0 at aa 5-24, 80-102, 117-139 and 152-171 282459005171 hypothetical protein; Provisional; Region: PRK08609 282459005172 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 282459005173 active site 282459005174 primer binding site [nucleotide binding]; other site 282459005175 NTP binding site [chemical binding]; other site 282459005176 metal binding triad [ion binding]; metal-binding site 282459005177 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 282459005178 active site 282459005179 Pfam match to entry PF02231 PHP_N, PHP domain N-terminal region, score 73.8, E-value 3.9e-19 282459005180 Pfam match to entry PF02811 PHP_C, PHP domain C-terminal region, score 49.3, E-value 9.1e-12 282459005181 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 282459005182 MutS domain III; Region: MutS_III; pfam05192 282459005183 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 282459005184 Walker A/P-loop; other site 282459005185 ATP binding site [chemical binding]; other site 282459005186 Q-loop/lid; other site 282459005187 ABC transporter signature motif; other site 282459005188 Walker B; other site 282459005189 D-loop; other site 282459005190 H-loop/switch region; other site 282459005191 Smr domain; Region: Smr; pfam01713 282459005192 PS00591 Glycosyl hydrolases family 10 active site. 282459005193 Pfam match to entry PF00488 MutS_V, MutS domain V, score 12.8, E-value 6.4e-15 282459005194 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005195 Pfam match to entry PF01713 Smr, Smr domain, score 122.5, E-value 8.5e-34 282459005196 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 282459005197 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 282459005198 catalytic residues [active] 282459005199 Pfam match to entry PF00085 thiored, Thioredoxin, score 146.8, E-value 3.9e-41 282459005200 PS00194 Thioredoxin family active site. 282459005201 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 282459005202 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 282459005203 GIY-YIG motif/motif A; other site 282459005204 active site 282459005205 catalytic site [active] 282459005206 putative DNA binding site [nucleotide binding]; other site 282459005207 metal binding site [ion binding]; metal-binding site 282459005208 UvrB/uvrC motif; Region: UVR; pfam02151 282459005209 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 282459005210 Pfam match to entry PF01541 Exci_endo_N, Endo/excinuclease amino terminal domain, score 118.4, E-value 1.4e-32 282459005211 Pfam match to entry PF02151 UVR, UvrB/uvrC motif, score 44.9, E-value 1.9e-10 282459005212 Signal peptide predicted for SAS1081 by SignalP 2.0 HMM (Signal peptide probabilty 0.875) with cleavage site probability 0.428 between residues 42 and 43; signal peptide 282459005213 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 282459005214 putative Iron-sulfur protein interface [polypeptide binding]; other site 282459005215 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 282459005216 proximal heme binding site [chemical binding]; other site 282459005217 distal heme binding site [chemical binding]; other site 282459005218 putative dimer interface [polypeptide binding]; other site 282459005219 5 probable transmembrane helices predicted for SAS1081 by TMHMM2.0 at aa 13-32, 52-74, 95-117, 145-167 and 180-202 282459005220 Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochrome b subunit, score 13.9, E-value 0.00026 282459005221 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 282459005222 Signal peptide predicted for SAS1082 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.846 between residues 22 and 23; signal peptide 282459005223 L-aspartate oxidase; Provisional; Region: PRK06175 282459005224 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 282459005225 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 282459005226 Pfam match to entry PF00890 FAD_binding_2, FAD binding domain, score 475.3, E-value 5.3e-140 282459005227 Pfam match to entry PF02910 succ_DH_flav_C, Fumarate reductase/succinate dehydrogenase flavoprotein C-terminal domain, score 183.2, E-value 4.5e-52 282459005228 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 282459005229 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 282459005230 Pfam match to entry PF00037 fer4, 4Fe-4S binding domain, score 13.9, E-value 0.0017 282459005231 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 282459005232 glutamate racemase; Provisional; Region: PRK00865 282459005233 Pfam match to entry PF01177 Asp_Glu_race, Asp/Glu/Hydantoin racemase, score 344.0, E-value 1.7e-100 282459005234 PS00923 Aspartate and glutamate racemases signature 1. 282459005235 PS00924 Aspartate and glutamate racemases signature 2. 282459005236 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 282459005237 active site 282459005238 dimerization interface [polypeptide binding]; other site 282459005239 Pfam match to entry PF01725 Ham1p_like, Ham1 family, score 255.2, E-value 9.6e-74 282459005240 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 282459005241 active site 282459005242 metal binding site [ion binding]; metal-binding site 282459005243 homotetramer interface [polypeptide binding]; other site 282459005244 Pfam match to entry PF00149 Metallophos, Calcineurin-like phosphoesterase, score 21.3, E-value 2.3e-05 282459005245 Signal peptide predicted for SAS1088 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 29 and 30; signal peptide 282459005246 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 282459005247 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 282459005248 Signal peptide predicted for SAS1089 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.794 between residues 28 and 29; signal peptide 282459005249 Signal peptide predicted for SAS1090 by SignalP 2.0 HMM (Signal peptide probabilty 0.798) with cleavage site probability 0.422 between residues 22 and 23; signal peptide 282459005250 5 probable transmembrane helices predicted for SAS1090 by TMHMM2.0 at aa 2-20, 35-57, 64-86, 101-120 and 141-160 282459005251 Signal peptide predicted for SAS1091 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.951 between residues 29 and 30; signal peptide 282459005252 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 282459005253 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 282459005254 Signal peptide predicted for SAS1092 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.720 between residues 31 and 32; signal peptide 282459005255 1 probable transmembrane helix predicted for SAS1094 by TMHMM2.0 at aa 38-60 282459005256 3 probable transmembrane helices predicted for SAS1095 by TMHMM2.0 at aa 2-24, 29-51 and 58-80 282459005257 Signal peptide predicted for SAS1097 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.937 between residues 26 and 27; signal peptide 282459005258 beta-channel forming cytolysin; Region: hlyII; TIGR01002 282459005259 Pfam match to entry PF01117 Aerolysin, Aerolysin/Hemolysin/Leukocidin toxin, score 109.0, E-value 9.7e-30 282459005260 PS00274 Aerolysin type toxins signature. 282459005261 1 probable transmembrane helix predicted for SAS1097a by TMHMM2.0 at aa 5-36 282459005262 superantigen-like protein; Reviewed; Region: PRK13350 282459005263 Signal peptide predicted for SAS1099 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.532 between residues 31 and 32; signal peptide 282459005264 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459005265 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score -21.6, E-value 0.062 282459005266 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459005267 Signal peptide predicted for SAS1100 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.398 between residues 36 and 37; signal peptide 282459005268 superantigen-like protein; Reviewed; Region: PRK13349 282459005269 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459005270 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 1.9, E-value 0.00086 282459005271 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459005272 superantigen-like protein; Reviewed; Region: PRK13043 282459005273 Signal peptide predicted for SAS1101 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.542 between residues 33 and 34; signal peptide 282459005274 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459005275 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 2.0, E-value 0.00085 282459005276 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459005277 ornithine carbamoyltransferase; Provisional; Region: PRK04284 282459005278 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 282459005279 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 282459005280 Pfam match to entry PF02729 OTCace_N, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain, score 236.6, E-value 3.6e-68 282459005281 PS00097 Aspartate and ornithine carbamoyltransferases signature. 282459005282 Pfam match to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain, score 276.5, E-value 3.7e-80 282459005283 carbamate kinase; Reviewed; Region: PRK12686 282459005284 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 282459005285 putative substrate binding site [chemical binding]; other site 282459005286 nucleotide binding site [chemical binding]; other site 282459005287 nucleotide binding site [chemical binding]; other site 282459005288 homodimer interface [polypeptide binding]; other site 282459005289 Pfam match to entry PF00696 aakinase, Amino acid kinase family, score 291.9, E-value 8.4e-85 282459005290 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005291 Signal peptide predicted for SAS1104 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.687 between residues 43 and 44; signal peptide 282459005292 Predicted membrane protein [Function unknown]; Region: COG1288 282459005293 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 282459005294 Pfam match to entry PF03606 DcuC, C4-dicarboxylate anaerobic carrier, score 841.0, E-value 4.3e-250 282459005295 13 probable transmembrane helices predicted for SAS1104 by TMHMM2.0 at aa 21-43, 127-149, 162-184, 189-211, 213-235, 245-267, 308-325, 329-351, 364-386, 406-428, 435-457, 462-481 and 494-516 282459005296 PS00012 Phosphopantetheine attachment site. 282459005297 2 probable transmembrane helices predicted for SAS1105 by TMHMM2.0 at aa 7-29 and 44-61 282459005298 Signal peptide predicted for SAS1106 by SignalP 2.0 HMM (Signal peptide probabilty 0.609) with cleavage site probability 0.176 between residues 28 and 29; signal peptide 282459005299 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 282459005300 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 282459005301 gating phenylalanine in ion channel; other site 282459005302 10 probable transmembrane helices predicted for SAS1106 by TMHMM2.0 at aa 7-24, 29-51, 64-86, 96-118, 130-149, 153-175, 187-209, 214-233, 246-268 and 278-300 282459005303 Predicted helix-turn-helix motif for SAS1107 with score 1183.000, SD 3.22 at aa 13-34, sequence LSSLHISKQTGVPQSTIHRMRK 282459005304 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 282459005305 Pfam match to entry PF05480 Staph_haemo, Staphylococcus haemolytic protein, score 95.2, E-value 1.3e-25 282459005306 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 282459005307 Pfam match to entry PF05480 Staph_haemo, Staphylococcus haemolytic protein, score 98.9, E-value 1.1e-26 282459005308 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 282459005309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459005310 motif II; other site 282459005311 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 66.5, E-value 5.9e-17 282459005312 hypothetical protein; Provisional; Region: PRK13688 282459005313 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 282459005314 Coenzyme A binding pocket [chemical binding]; other site 282459005315 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 23.9, E-value 0.00038 282459005316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 282459005317 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 282459005318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 282459005319 MraZ protein; Region: MraZ; pfam02381 282459005320 MraZ protein; Region: MraZ; pfam02381 282459005321 Pfam match to entry PF02381 UPF0040, Domain of unknown function UPF0040 family, score 116.7, E-value 4.6e-32 282459005322 Pfam match to entry PF02381 UPF0040, Domain of unknown function UPF0040 family, score 128.5, E-value 1.3e-35 282459005323 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 282459005324 MraW methylase family; Region: Methyltransf_5; pfam01795 282459005325 Pfam match to entry PF01795 Methyltransf_5, MraW methylase family, score 704.4, E-value 5.6e-209 282459005326 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 282459005327 1 probable transmembrane helix predicted for SAS1114 by TMHMM2.0 at aa 46-65 282459005328 Signal peptide predicted for SAS1115 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.423 between residues 42 and 43; signal peptide 282459005329 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 282459005330 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 282459005331 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 282459005332 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 282459005333 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 282459005334 1 probable transmembrane helix predicted for SAS1115 by TMHMM2.0 at aa 13-35 282459005335 Pfam match to entry PF03717 PBP_dimer, Penicillin-binding Protein dimerisation domain, score 205.1, E-value 1.1e-58 282459005336 Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain, score 389.1, E-value 4.6e-114 282459005337 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005338 Pfam match to entry PF03793 PASTA, PASTA domain, score 54.7, E-value 2.2e-13 282459005339 Pfam match to entry PF03793 PASTA, PASTA domain, score 63.6, E-value 4.3e-16 282459005340 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 282459005341 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 282459005342 Mg++ binding site [ion binding]; other site 282459005343 putative catalytic motif [active] 282459005344 putative substrate binding site [chemical binding]; other site 282459005345 10 probable transmembrane helices predicted for SAS1116 by TMHMM2.0 at aa 2-24, 47-69, 76-98, 113-135, 142-164, 174-196, 201-220, 225-244, 251-273 and 301-320 282459005346 Pfam match to entry PF00953 Glycos_transf_4, Glycosyl transferase, score 289.8, E-value 3.6e-84 282459005347 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 282459005348 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 282459005349 NAD binding site [chemical binding]; other site 282459005350 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 282459005351 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 282459005352 Pfam match to entry PF01225 Mur_ligase, Mur ligase family, catalytic domain, score 266.5, E-value 3.7e-77 282459005353 Pfam match to entry PF02875 Mur_ligase_C, Mur ligase family, glutamate ligase domain, score 68.2, E-value 1.8e-17 282459005354 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 282459005355 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 282459005356 Cell division protein FtsQ; Region: FtsQ; pfam03799 282459005357 Pfam match to entry PF03799 FtsQ, Cell division protein FtsQ, score 267.3, E-value 2.1e-77 282459005358 1 probable transmembrane helix predicted for SAS1118 by TMHMM2.0 at aa 172-194 282459005359 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 282459005360 Cell division protein FtsA; Region: FtsA; smart00842 282459005361 Cell division protein FtsA; Region: FtsA; pfam14450 282459005362 Pfam match to entry PF02491 FtsA, Cell division protein FtsA, score 168.8, E-value 9.5e-48 282459005363 Pfam match to entry PF02491 FtsA, Cell division protein FtsA, score 165.6, E-value 8.7e-47 282459005364 cell division protein FtsZ; Validated; Region: PRK09330 282459005365 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 282459005366 nucleotide binding site [chemical binding]; other site 282459005367 SulA interaction site; other site 282459005368 Pfam match to entry PF00091 tubulin, Tubulin/FtsZ family, GTPase domain, score 329.0, E-value 5.5e-96 282459005369 PS01134 FtsZ protein signature 1. 282459005370 PS01135 FtsZ protein signature 2. 282459005371 Pfam match to entry PF03953 tubulin_C, Tubulin/FtsZ family, C-terminal domain, score 121.8, E-value 1.4e-33 282459005372 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 282459005373 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 282459005374 Pfam match to entry PF02578 DUF152, Uncharacterised ACR, YfiH family COG1496, score 107.3, E-value 3.2e-29 282459005375 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 282459005376 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 282459005377 catalytic residue [active] 282459005378 Pfam match to entry PF01168 Ala_racemase_N, Alanine racemase, N-terminal domain, score 93.5, E-value 4.5e-25 282459005379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 282459005380 Pfam match to entry PF04472 DUF552, Protein of unknown function (DUF552), score 157.1, E-value 3.1e-44 282459005381 YGGT family; Region: YGGT; pfam02325 282459005382 Pfam match to entry PF02325 YGGT, YGGT family, score 115.7, E-value 9e-32 282459005383 2 probable transmembrane helices predicted for SAS1124 by TMHMM2.0 at aa 12-34 and 59-81 282459005384 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 282459005385 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 282459005386 RNA binding surface [nucleotide binding]; other site 282459005387 Pfam match to entry PF01479 S4, S4 domain, score 49.1, E-value 1e-11 282459005388 DivIVA protein; Region: DivIVA; pfam05103 282459005389 DivIVA domain; Region: DivI1A_domain; TIGR03544 282459005390 Pfam match to entry PF05103 DivIVA, DivIVA protein, score 75.4, E-value 1.2e-19 282459005391 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 282459005392 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 282459005393 HIGH motif; other site 282459005394 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 282459005395 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 282459005396 active site 282459005397 KMSKS motif; other site 282459005398 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 282459005399 tRNA binding surface [nucleotide binding]; other site 282459005400 anticodon binding site; other site 282459005401 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 282459005402 Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V), score 1136.6, E-value 0 282459005403 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282459005404 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 282459005405 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 282459005406 active site 282459005407 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 26.4, E-value 7.1e-05 282459005408 Probable gene remnant. Similar to the C-terminal region of Staphylococcus aureus prophage phiPV83 transposase SWALL:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 4e-20, 88.52% id in 61 aa; transposase (fragment) 282459005409 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 282459005410 Signal peptide predicted for SAS1130 by SignalP 2.0 HMM (Signal peptide probabilty 0.871) with cleavage site probability 0.636 between residues 26 and 27; signal peptide 282459005411 lipoprotein signal peptidase; Provisional; Region: PRK14787 282459005412 4 probable transmembrane helices predicted for SAS1130 by TMHMM2.0 at aa 7-29, 64-83, 90-109 and 129-151 282459005413 Pfam match to entry PF01252 Peptidase_A8, Signal peptidase (SPase) II, score 281.3, E-value 1.3e-81 282459005414 PS00855 Signal peptidases II signature. 282459005415 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 282459005416 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 282459005417 RNA binding surface [nucleotide binding]; other site 282459005418 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 282459005419 active site 282459005420 Pfam match to entry PF01479 S4, S4 domain, score 43.9, E-value 3.9e-10 282459005421 Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase, score 256.3, E-value 4.5e-74 282459005422 PS01129 Rlu family of pseudouridine synthase signature. 282459005423 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 282459005424 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 282459005425 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 59.4, E-value 8.3e-15 282459005426 uracil transporter; Provisional; Region: PRK10720 282459005427 Pfam match to entry PF00860 xan_ur_permease, Permease family, score 437.4, E-value 1.3e-128 282459005428 11 probable transmembrane helices predicted for SAS1133 by TMHMM2.0 at aa 47-69, 76-95, 100-122, 129-151, 166-183, 190-212, 240-262, 317-339, 349-371, 383-401 and 405-427 282459005429 PS01116 Xanthine/uracil permeases family signature. 282459005430 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 282459005431 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 282459005432 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 282459005433 Pfam match to entry PF02729 OTCace_N, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain, score 195.4, E-value 9.6e-56 282459005434 PS00097 Aspartate and ornithine carbamoyltransferases signature. 282459005435 Pfam match to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain, score 98.1, E-value 1.9e-26 282459005436 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 282459005437 dihydroorotase; Validated; Region: pyrC; PRK09357 282459005438 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 282459005439 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 282459005440 active site 282459005441 Pfam match to entry PF01979 Amidohydro_1, Amidohydrolase family, score 181.0, E-value 2e-51 282459005442 PS00482 Dihydroorotase signature 1. 282459005443 PS00483 Dihydroorotase signature 2. 282459005444 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 282459005445 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 282459005446 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 282459005447 catalytic site [active] 282459005448 subunit interface [polypeptide binding]; other site 282459005449 Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain, score 249.2, E-value 5.9e-72 282459005450 Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I, score 237.2, E-value 2.4e-68 282459005451 PS00442 Glutamine amidotransferases class-I active site. 282459005452 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 282459005453 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 282459005454 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 282459005455 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 282459005456 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 282459005457 ATP-grasp domain; Region: ATP-grasp_4; cl17255 282459005458 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 282459005459 IMP binding site; other site 282459005460 dimer interface [polypeptide binding]; other site 282459005461 interdomain contacts; other site 282459005462 partial ornithine binding site; other site 282459005463 Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase L chain, N-terminal domain, score 187.6, E-value 2e-53 282459005464 Pfam match to entry PF02786 CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain, score 443.6, E-value 1.8e-130 282459005465 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 282459005466 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 282459005467 Pfam match to entry PF02787 CPSase_L_D3, Carbamoyl-phosphate synthetase large chain, oligomerisation domain, score 227.2, E-value 2.4e-65 282459005468 Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase L chain, N-terminal domain, score 107.1, E-value 3.6e-29 282459005469 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 282459005470 Pfam match to entry PF02786 CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain, score 126.5, E-value 5.3e-35 282459005471 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 282459005472 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 282459005473 Pfam match to entry PF02142 MGS, MGS-like domain, score 117.9, E-value 2e-32 282459005474 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 282459005475 active site 282459005476 dimer interface [polypeptide binding]; other site 282459005477 Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylase / HUMPS family, score 293.8, E-value 2.2e-85 282459005478 PS00156 Orotidine 5'-phosphate decarboxylase active site. 282459005479 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282459005480 active site 282459005481 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 101.9, E-value 1.3e-27 282459005482 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 282459005483 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 282459005484 PS00012 Phosphopantetheine attachment site. 282459005485 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 282459005486 dimer interface [polypeptide binding]; other site 282459005487 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 282459005488 Domain of unknown function (DUF814); Region: DUF814; pfam05670 282459005489 Pfam match to entry PF05670 DUF814, Domain of unknown function (DUF814), score 147.0, E-value 3.5e-41 282459005490 Pfam match to entry PF05833 FbpA, Fibronectin-binding protein A N-terminus (FbpA), score 819.0, E-value 1.7e-243 282459005491 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 282459005492 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 282459005493 catalytic site [active] 282459005494 G-X2-G-X-G-K; other site 282459005495 PS00856 Guanylate kinase signature. 282459005496 Pfam match to entry PF00625 Guanylate_kin, Guanylate kinase, score 148.4, E-value 1.3e-41 282459005497 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 282459005498 Pfam match to entry PF01192 RNA_pol_Rpb6, RNA polymerase Rpb6, score 61.8, E-value 1.6e-15 282459005499 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 282459005500 Flavoprotein; Region: Flavoprotein; pfam02441 282459005501 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 282459005502 Pfam match to entry PF02441 Flavoprotein, Flavoprotein, score 179.9, E-value 4.2e-51 282459005503 Pfam match to entry PF04127 dfp, DNA / pantothenate metabolism flavoprotein, score 140.3, E-value 3.7e-39 282459005504 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 282459005505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282459005506 ATP binding site [chemical binding]; other site 282459005507 putative Mg++ binding site [ion binding]; other site 282459005508 helicase superfamily c-terminal domain; Region: HELICc; smart00490 282459005509 nucleotide binding region [chemical binding]; other site 282459005510 ATP-binding site [chemical binding]; other site 282459005511 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005512 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 26.0, E-value 9.5e-05 282459005513 Signal peptide predicted for SAS1147 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.352 between residues 29 and 30; signal peptide 282459005514 1 probable transmembrane helix predicted for SAS1147 by TMHMM2.0 at aa 5-24 282459005515 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459005516 Pfam match to entry PF03951 gln-synt_N, Glutamine synthetase, beta-Grasp domain, score 9.8, E-value 0.034 282459005517 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 282459005518 2 probable transmembrane helices predicted for SAS1148 by TMHMM2.0 at aa 31-50 and 57-79 282459005519 Pfam match to entry PF05154 TM2, TM2 domain, score 79.5, E-value 7.2e-21 282459005520 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 282459005521 active site 282459005522 catalytic residues [active] 282459005523 metal binding site [ion binding]; metal-binding site 282459005524 Pfam match to entry PF01327 Pep_deformylase, Polypeptide deformylase, score 94.9, E-value 1.6e-25 282459005525 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 282459005526 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 282459005527 putative active site [active] 282459005528 substrate binding site [chemical binding]; other site 282459005529 putative cosubstrate binding site; other site 282459005530 catalytic site [active] 282459005531 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 282459005532 substrate binding site [chemical binding]; other site 282459005533 Pfam match to entry PF00551 formyl_transf, Formyl transferase, score 171.0, E-value 2e-48 282459005534 Pfam match to entry PF02911 formyl_trans_C, Formyl transferase, C-terminal domain, score 104.2, E-value 2.7e-28 282459005535 16S rRNA methyltransferase B; Provisional; Region: PRK14902 282459005536 NusB family; Region: NusB; pfam01029 282459005537 putative RNA binding site [nucleotide binding]; other site 282459005538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459005539 S-adenosylmethionine binding site [chemical binding]; other site 282459005540 Pfam match to entry PF01029 NusB, NusB family, score 124.5, E-value 2.1e-34 282459005541 Pfam match to entry PF01189 Nol1_Nop2_Sun, NOL1/NOP2/sun family, score 151.8, E-value 1.2e-42 282459005542 PS00237 G-protein coupled receptors signature. 282459005543 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 282459005544 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282459005545 FeS/SAM binding site; other site 282459005546 Pfam match to entry PF04055 Radical_SAM, Radical SAM superfamily, score 75.4, E-value 1.3e-19 282459005547 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 282459005548 Protein phosphatase 2C; Region: PP2C; pfam00481 282459005549 active site 282459005550 Pfam match to entry PF00481 PP2C, Protein phosphatase 2C, score 18.1, E-value 2.8e-07 282459005551 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 282459005552 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 282459005553 active site 282459005554 ATP binding site [chemical binding]; other site 282459005555 substrate binding site [chemical binding]; other site 282459005556 activation loop (A-loop); other site 282459005557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 282459005558 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 282459005559 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 282459005560 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 282459005561 Pfam match to entry PF00069 pkinase, Protein kinase domain, score 208.7, E-value 9e-60 282459005562 PS00107 Protein kinases ATP-binding region signature. 282459005563 PS00108 Serine/Threonine protein kinases active-site signature. 282459005564 1 probable transmembrane helix predicted for SAS1154 by TMHMM2.0 at aa 350-372 282459005565 Pfam match to entry PF03793 PASTA, PASTA domain, score 71.3, E-value 2.2e-18 282459005566 Pfam match to entry PF03793 PASTA, PASTA domain, score 65.6, E-value 1.1e-16 282459005567 Pfam match to entry PF03793 PASTA, PASTA domain, score 82.2, E-value 1.2e-21 282459005568 Predicted GTPases [General function prediction only]; Region: COG1162 282459005569 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 282459005570 RNA binding site [nucleotide binding]; other site 282459005571 homodimer interface [polypeptide binding]; other site 282459005572 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 282459005573 GTPase/Zn-binding domain interface [polypeptide binding]; other site 282459005574 GTP/Mg2+ binding site [chemical binding]; other site 282459005575 G4 box; other site 282459005576 G5 box; other site 282459005577 G1 box; other site 282459005578 Switch I region; other site 282459005579 G2 box; other site 282459005580 G3 box; other site 282459005581 Switch II region; other site 282459005582 Pfam match to entry PF03193 DUF258, Protein of unknown function, DUF258, score 167.5, E-value 2.4e-47 282459005583 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 282459005584 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005585 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 282459005586 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 282459005587 substrate binding site [chemical binding]; other site 282459005588 hexamer interface [polypeptide binding]; other site 282459005589 metal binding site [ion binding]; metal-binding site 282459005590 Pfam match to entry PF00834 Ribul_P_3_epim, Ribulose-phosphate 3 epimerase family, score 352.9, E-value 3.5e-103 282459005591 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 282459005592 PS01086 Ribulose-phosphate 3-epimerase family signature 2. 282459005593 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 282459005594 Thiamine pyrophosphokinase; Region: TPK; cd07995 282459005595 active site 282459005596 dimerization interface [polypeptide binding]; other site 282459005597 thiamine binding site [chemical binding]; other site 282459005598 Pfam match to entry PF04263 TPK_catalytic, Thiamin pyrophosphokinase, catalytic domain, score 178.6, E-value 1.1e-50 282459005599 Pfam match to entry PF04265 TPK_B1_binding, Thiamin pyrophosphokinase, vitamin B1 binding domain, score 99.6, E-value 6.5e-27 282459005600 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 282459005601 Pfam match to entry PF00830 Ribosomal_L28, Ribosomal L28 family, score 98.0, E-value 2e-26 282459005602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 282459005603 Pfam match to entry PF03780 DUF322, Protein of unknown function (DUF322), score 142.2, E-value 9.7e-40 282459005604 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 282459005605 DAK2 domain; Region: Dak2; pfam02734 282459005606 Pfam match to entry PF02734 Dak2, DAK2 domain, score 194.1, E-value 2.3e-55 282459005607 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 282459005608 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 282459005609 generic binding surface II; other site 282459005610 ssDNA binding site; other site 282459005611 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282459005612 ATP binding site [chemical binding]; other site 282459005613 putative Mg++ binding site [ion binding]; other site 282459005614 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282459005615 nucleotide binding region [chemical binding]; other site 282459005616 ATP-binding site [chemical binding]; other site 282459005617 Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase, score 99.2, E-value 8.5e-27 282459005618 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005619 PS00435 Peroxidases proximal heme-ligand signature. 282459005620 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 81.6, E-value 1.7e-21 282459005621 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 282459005622 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 282459005623 active site 2 [active] 282459005624 active site 1 [active] 282459005625 putative phosphate acyltransferase; Provisional; Region: PRK05331 282459005626 Pfam match to entry PF02504 FA_synthesis, Fatty acid synthesis protein, score 494.9, E-value 6.6e-146 282459005627 PS00359 Ribosomal protein L11 signature. 282459005628 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 282459005629 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 282459005630 Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain, score 155.7, E-value 8.1e-44 282459005631 PS00157 Ribulose bisphosphate carboxylase large chain active site. 282459005632 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 282459005633 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 282459005634 NAD(P) binding site [chemical binding]; other site 282459005635 homotetramer interface [polypeptide binding]; other site 282459005636 homodimer interface [polypeptide binding]; other site 282459005637 active site 282459005638 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 334.1, E-value 1.6e-97 282459005639 PS00061 Short-chain dehydrogenases/reductases family signature. 282459005640 acyl carrier protein; Provisional; Region: acpP; PRK00982 282459005641 Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site, score 78.1, E-value 1.9e-20 282459005642 PS00012 Phosphopantetheine attachment site. 282459005643 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 282459005644 ribonuclease III; Reviewed; Region: rnc; PRK00102 282459005645 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 282459005646 dimerization interface [polypeptide binding]; other site 282459005647 active site 282459005648 metal binding site [ion binding]; metal-binding site 282459005649 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 282459005650 dsRNA binding site [nucleotide binding]; other site 282459005651 Pfam match to entry PF00636 Ribonuclease_3, RNase3 domain, score 169.1, E-value 7.6e-48 282459005652 PS00517 Ribonuclease III family signature. 282459005653 Pfam match to entry PF00035 dsrm, Double-stranded RNA binding motif, score 81.6, E-value 1.7e-21 282459005654 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 282459005655 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 282459005656 Walker A/P-loop; other site 282459005657 ATP binding site [chemical binding]; other site 282459005658 Q-loop/lid; other site 282459005659 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 282459005660 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 282459005661 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 282459005662 ABC transporter signature motif; other site 282459005663 Walker B; other site 282459005664 D-loop; other site 282459005665 H-loop/switch region; other site 282459005666 Pfam match to entry PF02463 SMC_N, RecF/RecN/SMC N terminal domain, score 255.0, E-value 1.1e-73 282459005667 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005668 Pfam match to entry PF02483 SMC_C, SMC family, C-terminal domain, score 367.7, E-value 1.3e-107 282459005669 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 282459005670 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 282459005671 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 282459005672 P loop; other site 282459005673 GTP binding site [chemical binding]; other site 282459005674 PS00018 EF-hand calcium-binding domain. 282459005675 Pfam match to entry PF02881 SRP54_N, SRP54-type protein, helical bundle domain, score 67.4, E-value 3.2e-17 282459005676 Pfam match to entry PF00448 SRP54, SRP54-type protein, GTPase domain, score 430.1, E-value 2.1e-126 282459005677 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005678 PS00300 SRP54-type proteins GTP-binding domain signature. 282459005679 putative DNA-binding protein; Validated; Region: PRK00118 282459005680 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 282459005681 Pfam match to entry PF04297 UPF0122, helix-turn-helix protein, YlxM / p13 like, score 225.2, E-value 1e-64 282459005682 Predicted helix-turn-helix motif for SAS1170 with score 1776.000, SD 5.24 at aa 39-60, sequence YSLSEIADTFNVSRQAVYDNIR 282459005683 signal recognition particle protein; Provisional; Region: PRK10867 282459005684 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 282459005685 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 282459005686 P loop; other site 282459005687 GTP binding site [chemical binding]; other site 282459005688 Signal peptide binding domain; Region: SRP_SPB; pfam02978 282459005689 Pfam match to entry PF02881 SRP54_N, SRP54-type protein, helical bundle domain, score 114.9, E-value 1.7e-31 282459005690 Pfam match to entry PF00448 SRP54, SRP54-type protein, GTPase domain, score 407.7, E-value 1.2e-119 282459005691 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005692 PS00300 SRP54-type proteins GTP-binding domain signature. 282459005693 Pfam match to entry PF02978 SRP_SPB, Signal peptide binding domain, score 179.3, E-value 6.4e-51 282459005694 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 282459005695 Pfam match to entry PF00886 Ribosomal_S16, Ribosomal protein S16, score 116.1, E-value 7e-32 282459005696 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 282459005697 RimM N-terminal domain; Region: RimM; pfam01782 282459005698 PRC-barrel domain; Region: PRC; pfam05239 282459005699 Pfam match to entry PF01782 RimM, RimM N-terminal domain, score 124.0, E-value 3e-34 282459005700 Pfam match to entry PF05239 PRC, PRC-barrel domain, score 90.2, E-value 4.2e-24 282459005701 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 282459005702 Pfam match to entry PF01746 tRNA_m1G_MT, tRNA (Guanine-1)-methyltransferase, score 443.6, E-value 1.8e-130 282459005703 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 282459005704 Pfam match to entry PF01245 Ribosomal_L19, Ribosomal protein L19, score 245.4, E-value 8.4e-71 282459005705 PS01015 Ribosomal protein L19 signature. 282459005706 Signal peptide predicted for SAS1176 by SignalP 2.0 HMM (Signal peptide probabilty 0.758) with cleavage site probability 0.259 between residues 29 and 30; signal peptide 282459005707 Predicted membrane protein [Function unknown]; Region: COG4485 282459005708 14 probable transmembrane helices predicted for SAS1176 by TMHMM2.0 at aa 13-35, 55-77, 84-103, 123-145, 165-187, 197-228, 249-271, 291-313, 320-342, 357-375, 382-401, 405-427, 432-449 and 843-865 282459005709 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 282459005710 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 282459005711 GTP/Mg2+ binding site [chemical binding]; other site 282459005712 G4 box; other site 282459005713 G5 box; other site 282459005714 G1 box; other site 282459005715 Switch I region; other site 282459005716 G2 box; other site 282459005717 G3 box; other site 282459005718 Switch II region; other site 282459005719 Pfam match to entry PF01926 MMR_HSR1, GTPase of unknown function, score 236.5, E-value 4.1e-68 282459005720 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005721 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 282459005722 RNA/DNA hybrid binding site [nucleotide binding]; other site 282459005723 active site 282459005724 Pfam match to entry PF01351 RNase_HII, Ribonuclease HII, score 214.1, E-value 2.2e-61 282459005725 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 282459005726 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 282459005727 CoA-ligase; Region: Ligase_CoA; pfam00549 282459005728 Pfam match to entry PF02222 ATP-grasp, ATP-grasp domain, score 189.9, E-value 4.3e-54 282459005729 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005730 Pfam match to entry PF00549 ligase-CoA, CoA-ligase, score 240.6, E-value 2.4e-69 282459005731 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 282459005732 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 282459005733 CoA binding domain; Region: CoA_binding; pfam02629 282459005734 CoA-ligase; Region: Ligase_CoA; pfam00549 282459005735 Pfam match to entry PF02629 CoA_binding, CoA binding domain, score 217.7, E-value 1.8e-62 282459005736 Pfam match to entry PF00549 ligase-CoA, CoA-ligase, score 186.0, E-value 6.5e-53 282459005737 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 282459005738 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 282459005739 Signal peptide predicted for SAS1181 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 38 and 39; signal peptide 282459005740 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 282459005741 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282459005742 CHAP domain; Region: CHAP; pfam05257 282459005743 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 33.6, E-value 4.8e-07 282459005744 1 probable transmembrane helix predicted for SAS1181 by TMHMM2.0 at aa 12-31 282459005745 Pfam match to entry PF01476 LysM, LysM domain, score 79.7, E-value 6.2e-21 282459005746 Pfam match to entry PF05257 CHAP, CHAP domain, score 140.1, E-value 4.1e-39 282459005747 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 282459005748 FemAB family; Region: FemAB; pfam02388 282459005749 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 282459005750 Pfam match to entry PF02388 FemAB, FemAB family, score 834.0, E-value 5.5e-248 282459005751 DNA protecting protein DprA; Region: dprA; TIGR00732 282459005752 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 282459005753 Pfam match to entry PF02481 SMF, SMF family, score 426.4, E-value 2.7e-125 282459005754 DNA topoisomerase I; Validated; Region: PRK05582 282459005755 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 282459005756 active site 282459005757 interdomain interaction site; other site 282459005758 putative metal-binding site [ion binding]; other site 282459005759 nucleotide binding site [chemical binding]; other site 282459005760 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 282459005761 domain I; other site 282459005762 DNA binding groove [nucleotide binding] 282459005763 phosphate binding site [ion binding]; other site 282459005764 domain II; other site 282459005765 domain III; other site 282459005766 nucleotide binding site [chemical binding]; other site 282459005767 catalytic site [active] 282459005768 domain IV; other site 282459005769 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 282459005770 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 282459005771 Pfam match to entry PF01751 Toprim, Toprim domain, score 136.8, E-value 4.1e-38 282459005772 Pfam match to entry PF01131 Topoisom_bac, DNA topoisomerase, score 608.8, E-value 3.4e-180 282459005773 PS00396 Prokaryotic DNA topoisomerase I active site. 282459005774 Pfam match to entry PF01396 zf-C4_Topoisom, Topoisomerase DNA binding C4 zinc finger, score 73.7, E-value 4.1e-19 282459005775 Pfam match to entry PF01396 zf-C4_Topoisom, Topoisomerase DNA binding C4 zinc finger, score 65.6, E-value 1.1e-16 282459005776 Pfam match to entry PF01396 zf-C4_Topoisom, Topoisomerase DNA binding C4 zinc finger, score 1.2, E-value 0.12 282459005777 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 282459005778 Glucose inhibited division protein A; Region: GIDA; pfam01134 282459005779 Pfam match to entry PF01134 GIDA, Glucose inhibited division protein A, score 480.3, E-value 1.6e-141 282459005780 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 282459005781 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 282459005782 active site 282459005783 DNA binding site [nucleotide binding] 282459005784 Int/Topo IB signature motif; other site 282459005785 Pfam match to entry PF02899 Phage_integr_N, Phage integrase, N-terminal SAM-like domain, score 66.2, E-value 7.5e-17 282459005786 Pfam match to entry PF00589 Phage_integrase, Phage integrase family, score 178.4, E-value 1.2e-50 282459005787 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 282459005788 active site 282459005789 HslU subunit interaction site [polypeptide binding]; other site 282459005790 Pfam match to entry PF00227 proteasome, Proteasome A-type and B-type, score 163.6, E-value 3.5e-46 282459005791 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 282459005792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459005793 Walker A motif; other site 282459005794 ATP binding site [chemical binding]; other site 282459005795 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 282459005796 Walker B motif; other site 282459005797 arginine finger; other site 282459005798 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 282459005799 Pfam match to entry PF00004 AAA, ATPase family associated with various cellular activities (AAA), score 29.0, E-value 2.1e-06 282459005800 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005801 transcriptional repressor CodY; Validated; Region: PRK04158 282459005802 CodY GAF-like domain; Region: CodY; pfam06018 282459005803 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 282459005804 Pfam match to entry PF06018 CodY, GTP-sensing transcriptional pleiotropic repressor CodY, score 448.0, E-value 8.4e-132 282459005805 Predicted helix-turn-helix motif for SAS1189 with score 1382.000, SD 3.89 at aa 201-222, sequence LIASKVADRVGITRSVIVNALR 282459005806 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 282459005807 rRNA interaction site [nucleotide binding]; other site 282459005808 S8 interaction site; other site 282459005809 putative laminin-1 binding site; other site 282459005810 PS00962 Ribosomal protein S2 signature 1. 282459005811 Pfam match to entry PF00318 Ribosomal_S2, Ribosomal protein S2, score 366.6, E-value 2.8e-107 282459005812 PS00963 Ribosomal protein S2 signature 2. 282459005813 elongation factor Ts; Provisional; Region: tsf; PRK09377 282459005814 UBA/TS-N domain; Region: UBA; pfam00627 282459005815 Elongation factor TS; Region: EF_TS; pfam00889 282459005816 Elongation factor TS; Region: EF_TS; pfam00889 282459005817 Pfam match to entry PF00627 UBA, UBA/TS-N domain, score 56.5, E-value 5.9e-14 282459005818 PS01126 Elongation factor Ts signature 1. 282459005819 Pfam match to entry PF00889 EF_TS, Elongation factor TS, score 356.2, E-value 3.6e-104 282459005820 PS01127 Elongation factor Ts signature 2. 282459005821 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 282459005822 putative nucleotide binding site [chemical binding]; other site 282459005823 uridine monophosphate binding site [chemical binding]; other site 282459005824 homohexameric interface [polypeptide binding]; other site 282459005825 Pfam match to entry PF00696 aakinase, Amino acid kinase family, score 222.8, E-value 5.2e-64 282459005826 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005827 ribosome recycling factor; Reviewed; Region: frr; PRK00083 282459005828 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 282459005829 hinge region; other site 282459005830 Pfam match to entry PF01765 RRF, Ribosome recycling factor, score 346.9, E-value 2.3e-101 282459005831 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 282459005832 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 282459005833 catalytic residue [active] 282459005834 putative FPP diphosphate binding site; other site 282459005835 putative FPP binding hydrophobic cleft; other site 282459005836 dimer interface [polypeptide binding]; other site 282459005837 putative IPP diphosphate binding site; other site 282459005838 Pfam match to entry PF01255 UPP_synthetase, undecaprenyl diphosphate synthase, score 343.2, E-value 3e-100 282459005839 PS01066 Undecaprenyl pyrophosphate synthetase family signature. 282459005840 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 282459005841 Signal peptide predicted for SAS1195 by SignalP 2.0 HMM (Signal peptide probabilty 0.963) with cleavage site probability 0.943 between residues 30 and 31; signal peptide 282459005842 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 282459005843 Pfam match to entry PF01148 CTP_transf_1, Cytidylyltransferase family, score 327.4, E-value 1.8e-95 282459005844 7 probable transmembrane helices predicted for SAS1195 by TMHMM2.0 at aa 7-29, 44-66, 73-95, 100-122, 129-151, 171-190 and 197-216 282459005845 PS01315 Phosphatidate cytidylyltransferase signature. 282459005846 RIP metalloprotease RseP; Region: TIGR00054 282459005847 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 282459005848 active site 282459005849 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 282459005850 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 282459005851 protein binding site [polypeptide binding]; other site 282459005852 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 282459005853 putative substrate binding region [chemical binding]; other site 282459005854 5 probable transmembrane helices predicted for SAS1196 by TMHMM2.0 at aa 4-21, 172-194, 309-331, 352-374 and 401-420 282459005855 Pfam match to entry PF02163 Peptidase_M50, Peptidase family M50, score 264.3, E-value 1.7e-76 282459005856 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282459005857 Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF), score 8.9, E-value 0.066 282459005858 prolyl-tRNA synthetase; Provisional; Region: PRK09194 282459005859 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 282459005860 dimer interface [polypeptide binding]; other site 282459005861 motif 1; other site 282459005862 active site 282459005863 motif 2; other site 282459005864 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 282459005865 putative deacylase active site [active] 282459005866 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 282459005867 active site 282459005868 motif 3; other site 282459005869 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 282459005870 anticodon binding site; other site 282459005871 Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II core domain (G, H, P, S and T), score 194.8, E-value 1.4e-55 282459005872 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 282459005873 Pfam match to entry PF04073 YbaK, YbaK / prolyl-tRNA synthetases associated domain, score 68.1, E-value 2e-17 282459005874 Pfam match to entry PF03129 HGTP_anticodon, Anticodon binding domain, score 95.0, E-value 1.6e-25 282459005875 DNA polymerase III PolC; Validated; Region: polC; PRK00448 282459005876 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 282459005877 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 282459005878 generic binding surface II; other site 282459005879 generic binding surface I; other site 282459005880 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 282459005881 active site 282459005882 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 282459005883 active site 282459005884 catalytic site [active] 282459005885 substrate binding site [chemical binding]; other site 282459005886 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 282459005887 Pfam match to entry PF02231 PHP_N, PHP domain N-terminal region, score 105.8, E-value 9e-29 282459005888 Pfam match to entry PF00929 Exonuclease, Exonuclease, score 213.8, E-value 2.7e-61 282459005889 Pfam match to entry PF02811 PHP_C, PHP domain C-terminal region, score 97.4, E-value 2.9e-26 282459005890 ribosome maturation protein RimP; Reviewed; Region: PRK00092 282459005891 Sm and related proteins; Region: Sm_like; cl00259 282459005892 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 282459005893 putative oligomer interface [polypeptide binding]; other site 282459005894 putative RNA binding site [nucleotide binding]; other site 282459005895 Pfam match to entry PF02576 DUF150, Uncharacterised BCR, YhbC family COG0779, score 244.8, E-value 1.2e-70 282459005896 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 282459005897 NusA N-terminal domain; Region: NusA_N; pfam08529 282459005898 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 282459005899 RNA binding site [nucleotide binding]; other site 282459005900 homodimer interface [polypeptide binding]; other site 282459005901 NusA-like KH domain; Region: KH_5; pfam13184 282459005902 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 282459005903 G-X-X-G motif; other site 282459005904 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 29.3, E-value 9.2e-06 282459005905 Pfam match to entry PF00013 KH, KH domain, score 31.6, E-value 2e-06 282459005906 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 282459005907 putative RNA binding cleft [nucleotide binding]; other site 282459005908 Pfam match to entry PF04296 DUF448, Protein of unknown function (DUF448), score 144.1, E-value 2.7e-40 282459005909 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 282459005910 Pfam match to entry PF01248 Ribosomal_L7Ae, Ribosomal protein L7Ae/L30e/S12e/Gadd45 family, score 63.4, E-value 5.2e-16 282459005911 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 282459005912 translation initiation factor IF-2; Region: IF-2; TIGR00487 282459005913 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 282459005914 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 282459005915 G1 box; other site 282459005916 putative GEF interaction site [polypeptide binding]; other site 282459005917 GTP/Mg2+ binding site [chemical binding]; other site 282459005918 Switch I region; other site 282459005919 G2 box; other site 282459005920 G3 box; other site 282459005921 Switch II region; other site 282459005922 G4 box; other site 282459005923 G5 box; other site 282459005924 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 282459005925 Translation-initiation factor 2; Region: IF-2; pfam11987 282459005926 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 282459005927 Pfam match to entry PF04760 IF2_N, Translation initiation factor IF-2, N-terminal region, score 87.7, E-value 2.4e-23 282459005928 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu GTP binding domain, score 183.6, E-value 3.3e-52 282459005929 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005930 Pfam match to entry PF03144 GTP_EFTU_D2, Elongation factor Tu domain 2, score 45.0, E-value 1.8e-10 282459005931 Pfam match to entry PF03144 GTP_EFTU_D2, Elongation factor Tu domain 2, score 35.8, E-value 1e-07 282459005932 PS01176 Initiation factor 2 signature. 282459005933 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 282459005934 Pfam match to entry PF02033 RBFA, Ribosome-binding factor A, score 163.6, E-value 3.5e-46 282459005935 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 282459005936 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 282459005937 RNA binding site [nucleotide binding]; other site 282459005938 active site 282459005939 Pfam match to entry PF01509 TruB_N, TruB family pseudouridylate synthase (N terminal domain), score 239.7, E-value 4.4e-69 282459005940 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 282459005941 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 282459005942 active site 282459005943 Riboflavin kinase; Region: Flavokinase; smart00904 282459005944 Pfam match to entry PF01687 FAD_Synth, Riboflavin kinase / FAD synthetase, score 195.4, E-value 9.6e-56 282459005945 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 282459005946 16S/18S rRNA binding site [nucleotide binding]; other site 282459005947 S13e-L30e interaction site [polypeptide binding]; other site 282459005948 25S rRNA binding site [nucleotide binding]; other site 282459005949 Pfam match to entry PF00312 Ribosomal_S15, Ribosomal protein S15, score 136.7, E-value 4.4e-38 282459005950 PS00362 Ribosomal protein S15 signature. 282459005951 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 282459005952 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 282459005953 RNase E interface [polypeptide binding]; other site 282459005954 trimer interface [polypeptide binding]; other site 282459005955 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 282459005956 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 282459005957 RNase E interface [polypeptide binding]; other site 282459005958 trimer interface [polypeptide binding]; other site 282459005959 active site 282459005960 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 282459005961 putative nucleic acid binding region [nucleotide binding]; other site 282459005962 G-X-X-G motif; other site 282459005963 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 282459005964 RNA binding site [nucleotide binding]; other site 282459005965 domain interface; other site 282459005966 Pfam match to entry PF01138 RNase_PH, 3' exoribonuclease family, domain 1, score 147.8, E-value 1.9e-41 282459005967 Pfam match to entry PF03725 RNase_PH_C, 3' exoribonuclease family, domain 2, score 62.7, E-value 8.3e-16 282459005968 Pfam match to entry PF03726 PNPase, Polyribonucleotide nucleotidyltransferase, RNA binding domain, score 56.5, E-value 6.2e-14 282459005969 Pfam match to entry PF01138 RNase_PH, 3' exoribonuclease family, domain 1, score 169.5, E-value 5.9e-48 282459005970 Pfam match to entry PF03725 RNase_PH_C, 3' exoribonuclease family, domain 2, score 92.3, E-value 1e-24 282459005971 Pfam match to entry PF00013 KH, KH domain, score 43.3, E-value 5.9e-10 282459005972 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 90.5, E-value 3.4e-24 282459005973 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 282459005974 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 282459005975 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 282459005976 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 74.9, E-value 1.8e-19 282459005977 Signal peptide predicted for SAS1210 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.528 between residues 55 and 56; signal peptide 282459005978 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 282459005979 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 282459005980 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 282459005981 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 282459005982 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 282459005983 5 probable transmembrane helices predicted for SAS1210 by TMHMM2.0 at aa 31-53, 63-85, 97-119, 134-151 and 158-180 282459005984 Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family, score 280.5, E-value 2.3e-81 282459005985 PS00017 ATP/GTP-binding site motif A (P-loop). 282459005986 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 282459005987 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 282459005988 DNA-binding site [nucleotide binding]; DNA binding site 282459005989 UTRA domain; Region: UTRA; pfam07702 282459005990 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 282459005991 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 282459005992 Pfam match to entry PF05193 Peptidase_M16_C, Peptidase M16 inactive domain, score 138.6, E-value 1.2e-38 282459005993 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 282459005994 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 282459005995 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 282459005996 Pfam match to entry PF00675 Peptidase_M16, Insulinase (Peptidase family M16), score 7.1, E-value 7.5e-05 282459005997 Pfam match to entry PF05193 Peptidase_M16_C, Peptidase M16 inactive domain, score 112.2, E-value 1.1e-30 282459005998 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 282459005999 classical (c) SDRs; Region: SDR_c; cd05233 282459006000 NAD(P) binding site [chemical binding]; other site 282459006001 active site 282459006002 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 135.6, E-value 9.3e-38 282459006003 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 282459006004 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 282459006005 Pfam match to entry PF01842 ACT, ACT domain, score 17.2, E-value 0.04 282459006006 1 probable transmembrane helix predicted for SAS1215 by TMHMM2.0 at aa 21-43 282459006007 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006008 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 282459006009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282459006010 non-specific DNA binding site [nucleotide binding]; other site 282459006011 salt bridge; other site 282459006012 sequence-specific DNA binding site [nucleotide binding]; other site 282459006013 Predicted helix-turn-helix motif for SAS1216 with score 1176.000, SD 3.19 at aa 17-38, sequence MTLTELEQRTGIKREMLVHIEN 282459006014 1 probable transmembrane helix predicted for SAS1216 by TMHMM2.0 at aa 107-129 282459006015 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 282459006016 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 282459006017 4 probable transmembrane helices predicted for SAS1217 by TMHMM2.0 at aa 7-29, 44-63, 84-106 and 157-179 282459006018 Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase, score 139.4, E-value 6.6e-39 282459006019 PS00379 CDP-alcohol phosphatidyltransferases signature. 282459006020 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 282459006021 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 282459006022 putative MPT binding site; other site 282459006023 Pfam match to entry PF00994 MoCF_biosynth, Probable molybdopterin binding domain, score 36.5, E-value 1.1e-08 282459006024 recombinase A; Provisional; Region: recA; PRK09354 282459006025 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 282459006026 hexamer interface [polypeptide binding]; other site 282459006027 Walker A motif; other site 282459006028 ATP binding site [chemical binding]; other site 282459006029 Walker B motif; other site 282459006030 Pfam match to entry PF00154 recA, recA bacterial DNA recombination protein, score 814.0, E-value 5.7e-242 282459006031 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006032 PS00321 recA signature. 282459006033 Signal peptide predicted for SAS1220 by SignalP 2.0 HMM (Signal peptide probabilty 0.960) with cleavage site probability 0.569 between residues 35 and 36; signal peptide 282459006034 phosphodiesterase; Provisional; Region: PRK12704 282459006035 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 282459006036 Zn2+ binding site [ion binding]; other site 282459006037 Mg2+ binding site [ion binding]; other site 282459006038 1 probable transmembrane helix predicted for SAS1220 by TMHMM2.0 at aa 2-24 282459006039 Pfam match to entry PF00013 KH, KH domain, score 26.7, E-value 5.7e-05 282459006040 Pfam match to entry PF01966 HD, HD domain, score 98.1, E-value 1.9e-26 282459006041 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 282459006042 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 282459006043 putative active site [active] 282459006044 metal binding site [ion binding]; metal-binding site 282459006045 homodimer binding site [polypeptide binding]; other site 282459006046 Pfam match to entry PF00149 Metallophos, Calcineurin-like phosphoesterase, score 34.6, E-value 2.4e-07 282459006047 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 282459006048 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 282459006049 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 282459006050 dimer interface [polypeptide binding]; other site 282459006051 PYR/PP interface [polypeptide binding]; other site 282459006052 TPP binding site [chemical binding]; other site 282459006053 substrate binding site [chemical binding]; other site 282459006054 Pfam match to entry PF01558 POR, Pyruvate ferredoxin/flavodoxin oxidoreductase, score 34.0, E-value 3.8e-08 282459006055 Pfam match to entry PF01855 POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain, score 282.8, E-value 4.7e-82 282459006056 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 282459006057 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 282459006058 TPP-binding site [chemical binding]; other site 282459006059 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 282459006060 Uncharacterized conserved protein [Function unknown]; Region: COG0011 282459006061 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 282459006062 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 282459006063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282459006064 FeS/SAM binding site; other site 282459006065 TRAM domain; Region: TRAM; pfam01938 282459006066 Pfam match to entry PF00919 UPF0004, Uncharacterized protein family UPF0004, score 175.5, E-value 9.4e-50 282459006067 Pfam match to entry PF04055 Radical_SAM, Radical SAM superfamily, score 137.2, E-value 3.1e-38 282459006068 PS01278 Uncharacterized protein family UPF0004 signature. 282459006069 Pfam match to entry PF01938 TRAM, TRAM domain, score 57.1, E-value 4e-14 282459006070 Predicted membrane protein [Function unknown]; Region: COG4550 282459006071 Predicted membrane protein [Function unknown]; Region: COG4732 282459006072 Signal peptide predicted for SAS1228 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 32 and 33; signal peptide 282459006073 5 probable transmembrane helices predicted for SAS1228 by TMHMM2.0 at aa 6-28, 37-59, 69-91, 98-120 and 130-152 282459006074 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 282459006075 MutS domain I; Region: MutS_I; pfam01624 282459006076 MutS domain II; Region: MutS_II; pfam05188 282459006077 MutS domain III; Region: MutS_III; pfam05192 282459006078 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 282459006079 Walker A/P-loop; other site 282459006080 ATP binding site [chemical binding]; other site 282459006081 Q-loop/lid; other site 282459006082 ABC transporter signature motif; other site 282459006083 Walker B; other site 282459006084 D-loop; other site 282459006085 H-loop/switch region; other site 282459006086 Pfam match to entry PF01624 MutS_I, MutS domain I, score 259.5, E-value 4.8e-75 282459006087 Pfam match to entry PF05188 MutS_II, MutS domain II, score 110.6, E-value 3.1e-30 282459006088 Pfam match to entry PF05192 MutS_III, MutS domain III, score 270.3, E-value 2.6e-78 282459006089 Pfam match to entry PF05190 MutS_IV, MutS family domain IV, score 146.3, E-value 5.6e-41 282459006090 Pfam match to entry PF00488 MutS_V, MutS domain V, score 480.8, E-value 1.1e-141 282459006091 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006092 PS00486 DNA mismatch repair proteins mutS family signature. 282459006093 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 282459006094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459006095 ATP binding site [chemical binding]; other site 282459006096 Mg2+ binding site [ion binding]; other site 282459006097 G-X-G motif; other site 282459006098 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 282459006099 ATP binding site [chemical binding]; other site 282459006100 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 282459006101 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 40.9, E-value 3.1e-09 282459006102 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 282459006103 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006104 Pfam match to entry PF01119 DNA_mis_repair, DNA mismatch repair protein, C-terminal domain, score 154.7, E-value 1.7e-43 282459006105 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 282459006106 Pfam match to entry PF04309 G3P_antiterm, Glycerol-3-phosphate responsive antiterminator, score 376.4, E-value 3e-110 282459006107 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 282459006108 Signal peptide predicted for SAS1232 by SignalP 2.0 HMM (Signal peptide probabilty 0.848) with cleavage site probability 0.453 between residues 32 and 33; signal peptide 282459006109 amphipathic channel; other site 282459006110 Asn-Pro-Ala signature motifs; other site 282459006111 Pfam match to entry PF00230 MIP, Major intrinsic protein, score 175.1, E-value 1.2e-49 282459006112 7 probable transmembrane helices predicted for SAS1232 by TMHMM2.0 at aa 5-27, 39-61, 81-103, 131-153, 163-185, 211-233 and 237-259 282459006113 PS00221 MIP family signature. 282459006114 glycerol kinase; Provisional; Region: glpK; PRK00047 282459006115 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 282459006116 N- and C-terminal domain interface [polypeptide binding]; other site 282459006117 active site 282459006118 MgATP binding site [chemical binding]; other site 282459006119 catalytic site [active] 282459006120 metal binding site [ion binding]; metal-binding site 282459006121 glycerol binding site [chemical binding]; other site 282459006122 homotetramer interface [polypeptide binding]; other site 282459006123 homodimer interface [polypeptide binding]; other site 282459006124 FBP binding site [chemical binding]; other site 282459006125 protein IIAGlc interface [polypeptide binding]; other site 282459006126 Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases, N-terminal domain, score 411.0, E-value 1.2e-120 282459006127 Pfam match to entry PF02782 FGGY_C, FGGY family of carbohydrate kinases, C-terminal domain, score 325.4, E-value 7e-95 282459006128 PS00445 FGGY family of carbohydrate kinases signature 2. 282459006129 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 282459006130 Pfam match to entry PF01266 DAO, FAD dependent oxidoreductase, score 410.1, E-value 2.2e-120 282459006131 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 282459006132 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 282459006133 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 282459006134 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 282459006135 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 282459006136 Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold, score 32.2, E-value 1.3e-06 282459006137 Signal peptide predicted for SAS1236 by SignalP 2.0 HMM (Signal peptide probabilty 0.805) with cleavage site probability 0.661 between residues 18 and 19; signal peptide 282459006138 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 282459006139 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 282459006140 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006141 Pfam match to entry PF01715 IPPT, IPP transferase, score 338.3, E-value 9e-99 282459006142 bacterial Hfq-like; Region: Hfq; cd01716 282459006143 hexamer interface [polypeptide binding]; other site 282459006144 Sm1 motif; other site 282459006145 RNA binding site [nucleotide binding]; other site 282459006146 Sm2 motif; other site 282459006147 Pfam match to entry PF01423 LSM, LSM domain, score 35.0, E-value 1.8e-07 282459006148 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 282459006149 catalytic residues [active] 282459006150 dimer interface [polypeptide binding]; other site 282459006151 Pfam match to entry PF00255 GSHPx, Glutathione peroxidase, score 172.1, E-value 1e-48 282459006152 PS00763 Glutathione peroxidases signature 2. 282459006153 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 282459006154 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 282459006155 HflX GTPase family; Region: HflX; cd01878 282459006156 G1 box; other site 282459006157 GTP/Mg2+ binding site [chemical binding]; other site 282459006158 Switch I region; other site 282459006159 G2 box; other site 282459006160 G3 box; other site 282459006161 Switch II region; other site 282459006162 G4 box; other site 282459006163 G5 box; other site 282459006164 Pfam match to entry PF04471 Mrr_cat, Restriction endonuclease, score 77.0, E-value 4.1e-20 282459006165 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006166 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 282459006167 Aluminium resistance protein; Region: Alum_res; pfam06838 282459006168 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 282459006169 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 282459006170 DNA binding residues [nucleotide binding] 282459006171 putative dimer interface [polypeptide binding]; other site 282459006172 Predicted helix-turn-helix motif for SAS1241 with score 1281.000, SD 3.55 at aa 14-35, sequence FSMSVVSKLTDLTPRQIRYYET 282459006173 Pfam match to entry PF00376 merR, MerR family regulatory protein, score 42.2, E-value 1.2e-09 282459006174 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 282459006175 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 282459006176 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 282459006177 Pfam match to entry PF03951 gln-synt_N, Glutamine synthetase, beta-Grasp domain, score 156.1, E-value 6.3e-44 282459006178 PS00180 Glutamine synthetase signature 1. 282459006179 Pfam match to entry PF00120 gln-synt, Glutamine synthetase, catalytic domain, score 495.9, E-value 3.2e-146 282459006180 PS00181 Glutamine synthetase ATP-binding region signature. 282459006181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 282459006182 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 282459006183 Ortholog of S. aureus MRSA252 (BX571856) SAR1304; Similar to Staphylococcus epidermidis conserved hypothetical protein SE2038 SWALL:Q8CR69 (EMBL:AE016750) (63 aa) fasta scores: E(): 0.22, 32.07% id in 53 aa. CDS contains a frameshift after codon 22. Frameshift occurs at a poly A hexamer; DNA binding protein (pseudogene) 282459006184 Similar to C-terminal region of Staphylococcus epidermidis conserved hypothetical protein se0990 SWALL:Q8CSR7 (EMBL:AE016747) (448 aa) fasta scores: E(): 6.9e-44, 62.1% id in 219 aa. N-terminal region is similar to an internal region of to Lactococcus lactis bacteriophage TP901-1 orf33 SWALL:Q9AZ64 (EMBL:AF304433) (564 aa) fasta scores: E(): 1.1e-06, 29.73% id in 185 aa;conserved hypothetical protein (fragment) 282459006185 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 282459006186 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 282459006187 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282459006188 catalytic residue [active] 282459006189 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 282459006190 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 282459006191 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 282459006192 putative active site [active] 282459006193 catalytic site [active] 282459006194 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 282459006195 putative active site [active] 282459006196 catalytic site [active] 282459006197 2 probable transmembrane helices predicted for SAS1258 by TMHMM2.0 at aa 12-34 and 44-66 282459006198 Pfam match to entry PF00614 PLDc, Phospholipase D. Active site motif, score 39.8, E-value 6.5e-09 282459006199 Pfam match to entry PF00614 PLDc, Phospholipase D. Active site motif, score 31.2, E-value 2.6e-06 282459006200 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 282459006201 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 282459006202 Walker A/P-loop; other site 282459006203 ATP binding site [chemical binding]; other site 282459006204 Q-loop/lid; other site 282459006205 ABC transporter signature motif; other site 282459006206 Walker B; other site 282459006207 D-loop; other site 282459006208 H-loop/switch region; other site 282459006209 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 123.7, E-value 3.6e-34 282459006210 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006211 PS00211 ABC transporters family signature. 282459006212 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 282459006213 6 probable transmembrane helices predicted for SAS1260 by TMHMM2.0 at aa 20-37, 52-74, 95-117, 137-156, 163-182 and 214-236 282459006214 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 282459006215 Histidine kinase; Region: HisKA_3; pfam07730 282459006216 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 282459006217 5 probable transmembrane helices predicted for SAS1261 by TMHMM2.0 at aa 12-31, 35-54, 61-83, 87-104 and 124-146 282459006218 Predicted helix-turn-helix motif for SAS1261 with score 1050.000, SD 2.76 at aa 272-293, sequence LSPTKQSMLVMITREAINNVIK 282459006219 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 31.4, E-value 2.1e-06 282459006220 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 282459006221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459006222 active site 282459006223 phosphorylation site [posttranslational modification] 282459006224 intermolecular recognition site; other site 282459006225 dimerization interface [polypeptide binding]; other site 282459006226 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 282459006227 DNA binding residues [nucleotide binding] 282459006228 dimerization interface [polypeptide binding]; other site 282459006229 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 102.0, E-value 1.2e-27 282459006230 Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family, score 36.2, E-value 7.7e-08 282459006231 Predicted helix-turn-helix motif for SAS1262 with score 1371.000, SD 3.86 at aa 155-176, sequence LSSKEISEKLFLTDGTVRNYTS 282459006232 2 probable transmembrane helices predicted for SAS1263 by TMHMM2.0 at aa 9-28 and 32-54 282459006233 Signal peptide predicted for SAS1264 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.490 between residues 33 and 34; signal peptide 282459006234 Staphylococcal nuclease homologues; Region: SNc; smart00318 282459006235 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 282459006236 Catalytic site; other site 282459006237 1 probable transmembrane helix predicted for SAS1264 by TMHMM2.0 at aa 7-24 282459006238 Pfam match to entry PF00565 SNase, Staphylococcal nuclease homologue, score 177.7, E-value 2.1e-50 282459006239 PS01284 Thermonuclease family signature 2. 282459006240 Signal peptide predicted for SAS1265 by SignalP 2.0 HMM (Signal peptide probabilty 0.892) with cleavage site probability 0.553 between residues 25 and 26; signal peptide 282459006241 AAA domain; Region: AAA_11; pfam13086 282459006242 1 probable transmembrane helix predicted for SAS1265 by TMHMM2.0 at aa 4-21 282459006243 aspartate kinase; Reviewed; Region: PRK09034 282459006244 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 282459006245 putative catalytic residues [active] 282459006246 putative nucleotide binding site [chemical binding]; other site 282459006247 putative aspartate binding site [chemical binding]; other site 282459006248 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 282459006249 allosteric regulatory residue; other site 282459006250 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 282459006251 Pfam match to entry PF01842 ACT, ACT domain, score 23.0, E-value 0.00072 282459006252 Pfam match to entry PF01842 ACT, ACT domain, score 13.7, E-value 0.13 282459006253 Pfam match to entry PF00696 aakinase, Amino acid kinase family, score 130.7, E-value 2.7e-36 282459006254 PS00324 Aspartokinase signature. 282459006255 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 282459006256 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 282459006257 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 282459006258 Pfam match to entry PF03447 NAD_binding_3, Homoserine dehydrogenase, NAD binding domain, score 143.5, E-value 4e-40 282459006259 Pfam match to entry PF00742 Homoserine_dh, Homoserine dehydrogenase, score 252.8, E-value 4.8e-73 282459006260 PS01042 Homoserine dehydrogenase signature. 282459006261 threonine synthase; Reviewed; Region: PRK06721 282459006262 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 282459006263 homodimer interface [polypeptide binding]; other site 282459006264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459006265 catalytic residue [active] 282459006266 Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme, score 344.2, E-value 1.5e-100 282459006267 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 282459006268 homoserine kinase; Provisional; Region: PRK01212 282459006269 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 282459006270 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 282459006271 Pfam match to entry PF00288 GHMP_kinases, GHMP kinases ATP-binding protein, score 123.1, E-value 5.3e-34 282459006272 PS00627 GHMP kinases ATP-binding domain. 282459006273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459006274 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 282459006275 active site 282459006276 motif I; other site 282459006277 motif II; other site 282459006278 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 282459006279 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 34.9, E-value 2e-07 282459006280 Signal peptide predicted for SAS1273 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.541 between residues 39 and 40; signal peptide 282459006281 lysine transporter; Provisional; Region: PRK10836 282459006282 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score 497.4, E-value 1.1e-146 282459006283 11 probable transmembrane helices predicted for SAS1273 by TMHMM2.0 at aa 15-37, 44-66, 93-115, 122-144, 159-181, 239-261, 284-306, 338-357, 367-389, 409-431 and 446-463 282459006284 PS00218 Amino acid permeases signature. 282459006285 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 282459006286 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 282459006287 tetramer interface [polypeptide binding]; other site 282459006288 heme binding pocket [chemical binding]; other site 282459006289 NADPH binding site [chemical binding]; other site 282459006290 Pfam match to entry PF00199 catalase, Catalase, score 881.4, E-value 3e-262 282459006291 PS00438 Catalase proximal active site signature. 282459006292 PS00437 Catalase proximal heme-ligand signature. 282459006293 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 282459006294 Pfam match to entry PF00471 Ribosomal_L33, Ribosomal protein L33, score 94.8, E-value 1.8e-25 282459006295 PS00582 Ribosomal protein L33 signature. 282459006296 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 282459006297 Pfam match to entry PF00253 Ribosomal_S14, Ribosomal protein S14p/S29e, score 140.2, E-value 3.8e-39 282459006298 PS00527 Ribosomal protein S14 signature. 282459006299 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 282459006300 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 282459006301 active site 282459006302 Pfam match to entry PF00478 IMPDH, IMP dehydrogenase / GMP reductase domain, score 472.4, E-value 3.8e-139 282459006303 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 282459006304 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 282459006305 Pfam match to entry PF00188 SCP, SCP-like extracellular protein, score 79.5, E-value 7.1e-21 282459006306 LexA repressor; Validated; Region: PRK00215 282459006307 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 282459006308 putative DNA binding site [nucleotide binding]; other site 282459006309 putative Zn2+ binding site [ion binding]; other site 282459006310 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 282459006311 Catalytic site [active] 282459006312 Pfam match to entry PF00717 Peptidase_S24, Peptidase family S24, score 152.1, E-value 9.9e-43 282459006313 Pfam match to entry PF01726 LexA_DNA_bind, LexA DNA binding domain, score 125.1, E-value 1.3e-34 282459006314 PS00228 Tubulin-beta mRNA autoregulation signal. 282459006315 Signal peptide predicted for SAS1280 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.689 between residues 37 and 38; signal peptide 282459006316 1 probable transmembrane helix predicted for SAS1280 by TMHMM2.0 at aa 13-35 282459006317 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 282459006318 Pfam match to entry PF05979 DUF896, Bacterial protein of unknown function (DUF896), score 157.5, E-value 2.4e-44 282459006319 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 282459006320 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 282459006321 TPP-binding site [chemical binding]; other site 282459006322 dimer interface [polypeptide binding]; other site 282459006323 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 282459006324 PYR/PP interface [polypeptide binding]; other site 282459006325 dimer interface [polypeptide binding]; other site 282459006326 TPP binding site [chemical binding]; other site 282459006327 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 282459006328 Pfam match to entry PF00456 transketolase, Transketolase, thiamine diphosphate binding domain, score 636.8, E-value 1.2e-188 282459006329 PS00801 Transketolase signature 1. 282459006330 Pfam match to entry PF02779 transket_pyr, Transketolase, pyridine binding domain, score 187.9, E-value 1.6e-53 282459006331 PS00802 Transketolase signature 2. 282459006332 Pfam match to entry PF02780 transketolase_C, Transketolase, C-terminal domain, score 15.9, E-value 4.1e-05 282459006333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 282459006334 1 probable transmembrane helix predicted for SAS1283 by TMHMM2.0 at aa 4-26 282459006335 Pfam match to entry PF03672 UPF0154, Uncharacterised protein family (UPF0154), score 103.8, E-value 3.5e-28 282459006336 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 282459006337 Signal peptide predicted for SAS1284 by SignalP 2.0 HMM (Signal peptide probabilty 0.607) with cleavage site probability 0.464 between residues 27 and 28; signal peptide 282459006338 5 probable transmembrane helices predicted for SAS1284 by TMHMM2.0 at aa 4-21, 34-56, 61-83, 95-114 and 124-143 282459006339 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 282459006340 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 282459006341 active site 282459006342 metal binding site [ion binding]; metal-binding site 282459006343 DNA binding site [nucleotide binding] 282459006344 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 282459006345 Pfam match to entry PF00149 Metallophos, Calcineurin-like phosphoesterase, score 68.2, E-value 1.8e-17 282459006346 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 282459006347 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 282459006348 Walker A/P-loop; other site 282459006349 ATP binding site [chemical binding]; other site 282459006350 Q-loop/lid; other site 282459006351 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 282459006352 ABC transporter signature motif; other site 282459006353 Walker B; other site 282459006354 D-loop; other site 282459006355 H-loop/switch region; other site 282459006356 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006357 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 282459006358 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 282459006359 Pfam match to entry PF01741 MscL, Large-conductance mechanosensitive channel, MscL, score 261.6, E-value 1.1e-75 282459006360 2 probable transmembrane helices predicted for SAS1287 by TMHMM2.0 at aa 13-35 and 65-84 282459006361 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 282459006362 11 probable transmembrane helices predicted for SAS1288 by TMHMM2.0 at aa 15-35, 56-78, 93-115, 190-212, 232-254, 263-285, 321-340, 353-375, 400-422, 443-465 and 475-497 282459006363 Pfam match to entry PF02028 BCCT, BCCT family transporter, score 755.3, E-value 2.7e-224 282459006364 PS01303 BCCT family of transporters signature. 282459006365 aconitate hydratase; Validated; Region: PRK09277 282459006366 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 282459006367 substrate binding site [chemical binding]; other site 282459006368 ligand binding site [chemical binding]; other site 282459006369 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 282459006370 substrate binding site [chemical binding]; other site 282459006371 Pfam match to entry PF00330 aconitase, Aconitase family (aconitate hydratase), score 760.5, E-value 7.2e-226 282459006372 PS00450 Aconitase family signature 1. 282459006373 PS01244 Aconitase family signature 2. 282459006374 Pfam match to entry PF00694 Aconitase_C, Aconitase C-terminal domain, score 217.4, E-value 2.3e-62 282459006375 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 282459006376 active site 282459006377 Pfam match to entry PF03061 4HBT, Thioesterase superfamily, score 71.9, E-value 1.4e-18 282459006378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 282459006379 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 282459006380 Pfam match to entry PF02660 DUF205, Domain of unknown function DUF, score 232.7, E-value 5.6e-67 282459006381 5 probable transmembrane helices predicted for SAS1293 by TMHMM2.0 at aa 4-26, 52-74, 84-106, 118-140 and 150-182 282459006382 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 282459006383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459006384 ATP binding site [chemical binding]; other site 282459006385 Mg2+ binding site [ion binding]; other site 282459006386 G-X-G motif; other site 282459006387 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 282459006388 anchoring element; other site 282459006389 dimer interface [polypeptide binding]; other site 282459006390 ATP binding site [chemical binding]; other site 282459006391 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 282459006392 active site 282459006393 putative metal-binding site [ion binding]; other site 282459006394 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 282459006395 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 118.5, E-value 1.3e-32 282459006396 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006397 Pfam match to entry PF00204 DNA_gyraseB, DNA gyrase B, score 311.5, E-value 1e-90 282459006398 Pfam match to entry PF01751 Toprim, Toprim domain, score 29.0, E-value 1.1e-05 282459006399 PS00177 DNA topoisomerase II signature. 282459006400 Pfam match to entry PF00986 DNA_gyraseB_C, DNA gyrase B subunit, carboxyl terminus, score 157.6, E-value 2.3e-44 282459006401 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 282459006402 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 282459006403 CAP-like domain; other site 282459006404 active site 282459006405 primary dimer interface [polypeptide binding]; other site 282459006406 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 282459006407 Pfam match to entry PF00521 DNA_topoisoIV, DNA gyrase/topoisomerase IV, subunit A, score 983.1, E-value 6.9e-293 282459006408 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller, score 28.4, E-value 1.8e-05 282459006409 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller, score 29.9, E-value 6.2e-06 282459006410 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller, score 30.8, E-value 3.3e-06 282459006411 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller, score 28.8, E-value 1.3e-05 282459006412 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller, score 32.9, E-value 7.6e-07 282459006413 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 282459006414 amino acid carrier protein; Region: agcS; TIGR00835 282459006415 9 probable transmembrane helices predicted for SAS1296 by TMHMM2.0 at aa 22-41, 90-112, 155-172, 193-215, 219-241, 309-331, 357-379, 392-411 and 422-444 282459006416 Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family, score 692.6, E-value 2.1e-205 282459006417 PS00873 Sodium:alanine symporter family signature. 282459006418 CAT RNA binding domain; Region: CAT_RBD; smart01061 282459006419 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 282459006420 PRD domain; Region: PRD; pfam00874 282459006421 PRD domain; Region: PRD; pfam00874 282459006422 Pfam match to entry PF03123 CAT_RBD, CAT RNA binding domain, score 88.4, E-value 1.5e-23 282459006423 Pfam match to entry PF00874 PRD, PRD domain, score 112.3, E-value 9.5e-31 282459006424 PS00654 Transcriptional antiterminators bglG family signature. 282459006425 Pfam match to entry PF00874 PRD, PRD domain, score 110.6, E-value 3.2e-30 282459006426 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 282459006427 Domain of unknown function DUF20; Region: UPF0118; pfam01594 282459006428 8 probable transmembrane helices predicted for SAS1299 by TMHMM2.0 at aa 23-45, 55-77, 97-119, 182-204, 242-264, 269-291, 296-318 and 338-360 282459006429 Pfam match to entry PF01594 UPF0118, Domain of unknown function DUF20, score 304.2, E-value 1.6e-88 282459006430 Predicted integral membrane protein [Function unknown]; Region: COG0392 282459006431 Uncharacterized conserved protein [Function unknown]; Region: COG2898 282459006432 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 282459006433 14 probable transmembrane helices predicted for SAS1300 by TMHMM2.0 at aa 9-31, 51-73, 94-116, 131-153, 162-184, 194-216, 229-251, 271-293, 336-358, 368-390, 397-416, 420-439, 451-473 and 488-510 282459006434 Pfam match to entry PF03706 UPF0104, Uncharacterised protein family (UPF0104), score 20.4, E-value 8.2e-06 282459006435 Pfam match to entry PF04329 DUF470, Family of unknown function (DUF470), score 264.9, E-value 1.2e-76 282459006436 Pfam match to entry PF04330 DUF471, Family of unknown function (DUF471), score 122.5, E-value 8.4e-34 282459006437 Pfam match to entry PF04331 DUF472, Family of unknown function (DUF472), score 183.1, E-value 4.7e-52 282459006438 methionine sulfoxide reductase A; Provisional; Region: PRK14054 282459006439 Pfam match to entry PF01625 PMSR, Peptide methionine sulfoxide reductase, score 258.9, E-value 7.3e-75 282459006440 Signal peptide predicted for SAS1302 by SignalP 2.0 HMM (Signal peptide probabilty 0.973) with cleavage site probability 0.357 between residues 53 and 54; signal peptide 282459006441 Transcriptional regulator [Transcription]; Region: LytR; COG1316 282459006442 1 probable transmembrane helix predicted for SAS1302 by TMHMM2.0 at aa 32-54 282459006443 Pfam match to entry PF03816 LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain, score 271.4, E-value 1.3e-78 282459006444 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 282459006445 active site 1 [active] 282459006446 dimer interface [polypeptide binding]; other site 282459006447 hexamer interface [polypeptide binding]; other site 282459006448 active site 2 [active] 282459006449 Pfam match to entry PF01361 Tautomerase, Tautomerase enzyme, score 102.3, E-value 9.9e-28 282459006450 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 282459006451 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 282459006452 active site 282459006453 DNA binding site [nucleotide binding] 282459006454 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 282459006455 Pfam match to entry PF00817 IMS, impB/mucB/samB family, score 307.2, E-value 2.1e-89 282459006456 prephenate dehydrogenase; Validated; Region: PRK06545 282459006457 prephenate dehydrogenase; Validated; Region: PRK08507 282459006458 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 282459006459 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 282459006460 Pfam match to entry PF02153 PDH, Prephenate dehydrogenase, score 291.6, E-value 1e-84 282459006461 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 282459006462 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 282459006463 putative oligomer interface [polypeptide binding]; other site 282459006464 putative active site [active] 282459006465 metal binding site [ion binding]; metal-binding site 282459006466 Pfam match to entry PF05343 Peptidase_M42, M42 glutamyl aminopeptidase, score 417.2, E-value 1.6e-122 282459006467 anthranilate synthase component I; Provisional; Region: PRK13567 282459006468 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 282459006469 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 282459006470 Pfam match to entry PF04715 Anth_synt_I_N, Anthranilate synthase component I, N terminal region, score 103.2, E-value 5.1e-28 282459006471 Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme, score 384.5, E-value 1.1e-112 282459006472 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 282459006473 Glutamine amidotransferase class-I; Region: GATase; pfam00117 282459006474 glutamine binding [chemical binding]; other site 282459006475 catalytic triad [active] 282459006476 Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I, score 154.6, E-value 1.8e-43 282459006477 PS00442 Glutamine amidotransferases class-I active site. 282459006478 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 282459006479 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 282459006480 Pfam match to entry PF00591 Glycos_transf_3, Glycosyl transferase family, a/b domain, score 308.7, E-value 7.1e-90 282459006481 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 282459006482 active site 282459006483 ribulose/triose binding site [chemical binding]; other site 282459006484 phosphate binding site [ion binding]; other site 282459006485 substrate (anthranilate) binding pocket [chemical binding]; other site 282459006486 product (indole) binding pocket [chemical binding]; other site 282459006487 Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthase, score 273.8, E-value 2.3e-79 282459006488 PS00614 Indole-3-glycerol phosphate synthase signature. 282459006489 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282459006490 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 282459006491 active site 282459006492 Pfam match to entry PF00697 PRAI, N-(5'phosphoribosyl)anthranilate (PRA) isomerase, score 119.7, E-value 5.8e-33 282459006493 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 282459006494 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 282459006495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459006496 catalytic residue [active] 282459006497 Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme, score 383.2, E-value 2.7e-112 282459006498 PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 282459006499 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 282459006500 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 282459006501 substrate binding site [chemical binding]; other site 282459006502 active site 282459006503 catalytic residues [active] 282459006504 heterodimer interface [polypeptide binding]; other site 282459006505 Pfam match to entry PF00290 trp_syntA, Tryptophan synthase alpha chain, score 227.6, E-value 1.9e-65 282459006506 PS00167 Tryptophan synthase alpha chain signature. 282459006507 FemAB family; Region: FemAB; pfam02388 282459006508 FlxA-like protein; Region: FlxA; pfam14282 282459006509 Pfam match to entry PF02388 FemAB, FemAB family, score 902.2, E-value 1.5e-268 282459006510 FemAB family; Region: FemAB; pfam02388 282459006511 Pfam match to entry PF02388 FemAB, FemAB family, score 810.2, E-value 7.9e-241 282459006512 Signal peptide predicted for SAS1316 by SignalP 2.0 HMM (Signal peptide probabilty 0.880) with cleavage site probability 0.319 between residues 30 and 31; signal peptide 282459006513 5 probable transmembrane helices predicted for SAS1316 by TMHMM2.0 at aa 12-34, 65-82, 94-116, 150-172 and 185-207 282459006514 Ortholog of S. aureus MRSA252 (BX571856) SAR1389; Similar to Pasteurella multocida hypothetical protein PM0231 SWALL:Q9CP34 (EMBL:AE006057) (251 aa) fasta scores: E(): 6.2e-18, 40.7% id in 226 aa, and to Streptococcus agalactiae conserved hypothetical protein SAG1133 SWALL:Q8DZG8 (EMBL:AE014243) (254 aa) fasta scores: E(): 1.2e-07, 28.87% id in 239 aa. CDS contains a frameshift after codon 39;conserved hypothetical protein (pseudogene) 282459006515 SWIM zinc finger; Region: SWIM; pfam04434 282459006516 Pfam match to entry PF04434 SWIM, SWIM zinc finger, score 35.5, E-value 1.3e-07 282459006517 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 282459006518 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282459006519 Walker A/P-loop; other site 282459006520 ATP binding site [chemical binding]; other site 282459006521 Q-loop/lid; other site 282459006522 ABC transporter signature motif; other site 282459006523 Walker B; other site 282459006524 D-loop; other site 282459006525 H-loop/switch region; other site 282459006526 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 143.9, E-value 2.9e-40 282459006527 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006528 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282459006529 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 282459006530 Walker A/P-loop; other site 282459006531 ATP binding site [chemical binding]; other site 282459006532 Q-loop/lid; other site 282459006533 ABC transporter signature motif; other site 282459006534 Walker B; other site 282459006535 D-loop; other site 282459006536 H-loop/switch region; other site 282459006537 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 131.0, E-value 2.2e-36 282459006538 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006539 Signal peptide predicted for SAS1322 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.785 between residues 34 and 35; signal peptide 282459006540 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 282459006541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459006542 dimer interface [polypeptide binding]; other site 282459006543 conserved gate region; other site 282459006544 putative PBP binding loops; other site 282459006545 ABC-ATPase subunit interface; other site 282459006546 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 182.9, E-value 5.4e-52 282459006547 5 probable transmembrane helices predicted for SAS1322 by TMHMM2.0 at aa 10-29, 73-95, 115-137, 190-212 and 232-254 282459006548 Signal peptide predicted for SAS1323 by SignalP 2.0 HMM (Signal peptide probabilty 0.961) with cleavage site probability 0.859 between residues 34 and 35; signal peptide 282459006549 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 282459006550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459006551 dimer interface [polypeptide binding]; other site 282459006552 conserved gate region; other site 282459006553 putative PBP binding loops; other site 282459006554 ABC-ATPase subunit interface; other site 282459006555 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 184.7, E-value 1.5e-52 282459006556 6 probable transmembrane helices predicted for SAS1323 by TMHMM2.0 at aa 7-29, 104-126, 139-161, 171-193, 228-250 and 278-300 282459006557 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282459006558 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 282459006559 3 probable transmembrane helices predicted for SAS1324 by TMHMM2.0 at aa 10-29, 31-50 and 60-82 282459006560 oligoendopeptidase F; Region: pepF; TIGR00181 282459006561 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 282459006562 active site 282459006563 Zn binding site [ion binding]; other site 282459006564 Pfam match to entry PF01432 Peptidase_M3, Peptidase family M3, score 138.2, E-value 1.6e-38 282459006565 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282459006566 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 282459006567 PhoU domain; Region: PhoU; pfam01895 282459006568 PhoU domain; Region: PhoU; pfam01895 282459006569 Pfam match to entry PF01895 PhoU, PhoU family, score 78.3, E-value 1.7e-20 282459006570 Pfam match to entry PF01895 PhoU, PhoU family, score 67.0, E-value 4.3e-17 282459006571 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 282459006572 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 282459006573 Walker A/P-loop; other site 282459006574 ATP binding site [chemical binding]; other site 282459006575 Q-loop/lid; other site 282459006576 ABC transporter signature motif; other site 282459006577 Walker B; other site 282459006578 D-loop; other site 282459006579 H-loop/switch region; other site 282459006580 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 216.2, E-value 5.2e-62 282459006581 PS00211 ABC transporters family signature. 282459006582 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006583 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 282459006584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459006585 dimer interface [polypeptide binding]; other site 282459006586 conserved gate region; other site 282459006587 putative PBP binding loops; other site 282459006588 ABC-ATPase subunit interface; other site 282459006589 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 81.8, E-value 1.5e-21 282459006590 6 probable transmembrane helices predicted for SAS1328 by TMHMM2.0 at aa 33-55, 86-108, 128-150, 155-177, 207-229 and 275-297 282459006591 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282459006592 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 282459006593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459006594 dimer interface [polypeptide binding]; other site 282459006595 conserved gate region; other site 282459006596 ABC-ATPase subunit interface; other site 282459006597 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 90.1, E-value 4.8e-24 282459006598 6 probable transmembrane helices predicted for SAS1329 by TMHMM2.0 at aa 25-47, 79-111, 124-146, 161-180, 209-231 and 275-297 282459006599 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282459006600 Signal peptide predicted for SAS1330 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.185 between residues 29 and 30; signal peptide 282459006601 phosphate binding protein; Region: ptsS_2; TIGR02136 282459006602 Pfam match to entry PF01547 SBP_bac_1, Bacterial extracellular solute-binding protein, score 34.5, E-value 2.6e-07 282459006603 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459006604 Probable gene remnant. Similar to an internal region of Bacillus halodurans transposase bh2070 SWALL:Q9KB61 (EMBL:AP001514) (618 aa) fasta scores: E(): 0.0001, 36.45% id in 96 aa, and to the C-terminal region of Methanosarcina acetivorans transposase ma2770 SWALL:Q8TM97 (EMBL:AE010976) (494 aa) fasta scores: E(): 0.076, 29.03% id in 93 aa;transposase (fragment) 282459006605 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 282459006606 S1 domain; Region: S1_2; pfam13509 282459006607 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 282459006608 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282459006609 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282459006610 ABC transporter; Region: ABC_tran_2; pfam12848 282459006611 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282459006612 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 131.1, E-value 2.1e-36 282459006613 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006614 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 70.0, E-value 5.4e-18 282459006615 aspartate kinase; Reviewed; Region: PRK06635 282459006616 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 282459006617 putative nucleotide binding site [chemical binding]; other site 282459006618 putative catalytic residues [active] 282459006619 putative Mg ion binding site [ion binding]; other site 282459006620 putative aspartate binding site [chemical binding]; other site 282459006621 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 282459006622 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 282459006623 Pfam match to entry PF00696 aakinase, Amino acid kinase family, score 163.7, E-value 3.3e-46 282459006624 PS00324 Aspartokinase signature. 282459006625 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 282459006626 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 282459006627 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 282459006628 Pfam match to entry PF01118 Semialdhyde_dh, Semialdehyde dehydrogenase, NAD binding domain, score 126.5, E-value 5e-35 282459006629 Pfam match to entry PF02774 Semialdhyde_dhC, Semialdehyde dehydrogenase, dimerisation domain, score 188.4, E-value 1.2e-53 282459006630 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 282459006631 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 282459006632 dimer interface [polypeptide binding]; other site 282459006633 active site 282459006634 catalytic residue [active] 282459006635 Pfam match to entry PF00701 DHDPS, Dihydrodipicolinate synthetase family, score 270.8, E-value 1.9e-78 282459006636 PS00666 Dihydrodipicolinate synthetase signature 2. 282459006637 dihydrodipicolinate reductase; Provisional; Region: PRK00048 282459006638 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 282459006639 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 282459006640 Pfam match to entry PF01113 DapB_N, Dihydrodipicolinate reductase, N-terminus, score 104.7, E-value 1.9e-28 282459006641 Pfam match to entry PF05173 DapB_C, Dihydrodipicolinate reductase, C-terminus, score 225.5, E-value 8.3e-65 282459006642 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 282459006643 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 282459006644 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 282459006645 active site 282459006646 trimer interface [polypeptide binding]; other site 282459006647 substrate binding site [chemical binding]; other site 282459006648 CoA binding site [chemical binding]; other site 282459006649 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 10.8, E-value 3.5 282459006650 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 15.7, E-value 0.11 282459006651 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 9.9, E-value 6.2 282459006652 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 16.7, E-value 0.057 282459006653 PS00101 Hexapeptide-repeat containing-transferases signature. 282459006654 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 10.4, E-value 4.6 282459006655 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 282459006656 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 282459006657 metal binding site [ion binding]; metal-binding site 282459006658 dimer interface [polypeptide binding]; other site 282459006659 Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40, score 304.7, E-value 1.2e-88 282459006660 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 282459006661 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 282459006662 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 282459006663 catalytic residue [active] 282459006664 Pfam match to entry PF01168 Ala_racemase_N, Alanine racemase, N-terminal domain, score 202.8, E-value 5.5e-58 282459006665 Pfam match to entry PF00842 Ala_racemase_C, Alanine racemase, C-terminal domain, score 138.7, E-value 1.1e-38 282459006666 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 282459006667 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 282459006668 active site 282459006669 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 282459006670 substrate binding site [chemical binding]; other site 282459006671 catalytic residues [active] 282459006672 dimer interface [polypeptide binding]; other site 282459006673 Pfam match to entry PF02784 Orn_Arg_deC_N, Pyridoxal-dependent decarboxylase, pyridoxal binding domain, score 263.4, E-value 3.1e-76 282459006674 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 282459006675 Pfam match to entry PF00278 Orn_DAP_Arg_deC, Pyridoxal-dependent decarboxylase, C-terminal sheet domain, score 169.4, E-value 6.1e-48 282459006676 Signal peptide predicted for SAS1342 by SignalP 2.0 HMM (Signal peptide probabilty 0.843) with cleavage site probability 0.324 between residues 29 and 30; signal peptide 282459006677 4 probable transmembrane helices predicted for SAS1342 by TMHMM2.0 at aa 3-21, 25-47, 54-76 and 108-125 282459006678 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 282459006679 DNA-binding site [nucleotide binding]; DNA binding site 282459006680 RNA-binding motif; other site 282459006681 Pfam match to entry PF00313 CSD, 'Cold-shock' DNA-binding domain, score 148.8, E-value 9.7e-42 282459006682 PS00352 'Cold-shock' DNA-binding domain signature. 282459006683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 282459006684 Pfam match to entry PF06279 DUF1033, Protein of unknown function (DUF1033), score 25.5, E-value 2.9e-10 282459006685 Pfam match to entry PF00708 Acylphosphatase, Acylphosphatase, score 27.6, E-value 1.1e-07 282459006686 acylphosphatase; Provisional; Region: PRK14431 282459006687 PS00150 Acylphosphatase signature 1. 282459006688 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 282459006689 Signal peptide predicted for SAS1346 by SignalP 2.0 HMM (Signal peptide probabilty 0.622) with cleavage site probability 0.291 between residues 34 and 35; signal peptide 282459006690 2 probable transmembrane helices predicted for SAS1346 by TMHMM2.0 at aa 7-29 and 33-51 282459006691 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 282459006692 Pfam match to entry PF05816 TelA, Toxic anion resistance protein (TelA), score 610.4, E-value 1.1e-180 282459006693 Probable gene remnant. Similar to the C-terminal regions of Staphylococcus aureus prophage phiPV83 transposase SWALL:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 8.9e-55, 81.86% id in 182 aa, and to Bacillus halodurans cassette chromosome recombinase B1 bh0682 SWALL:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 3e-23, 45.45% id in 176 aa; transposase (fragment) 282459006694 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 282459006695 Signal peptide predicted for SAS1350 by SignalP 2.0 HMM (Signal peptide probabilty 0.960) with cleavage site probability 0.487 between residues 30 and 31; signal peptide 282459006696 Pfam match to entry PF05525 Branch_AA_trans, Branched-chain amino acid transport protein, score 762.0, E-value 2.5e-226 282459006697 12 probable transmembrane helices predicted for SAS1350 by TMHMM2.0 at aa 7-25, 35-57, 77-94, 109-131, 143-160, 193-215, 228-250, 292-314, 321-338, 348-370, 382-404 and 419-437 282459006698 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 282459006699 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 282459006700 metal ion-dependent adhesion site (MIDAS); other site 282459006701 MoxR-like ATPases [General function prediction only]; Region: COG0714 282459006702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459006703 Walker A motif; other site 282459006704 ATP binding site [chemical binding]; other site 282459006705 Walker B motif; other site 282459006706 arginine finger; other site 282459006707 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006708 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 282459006709 active site 282459006710 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 282459006711 active site 282459006712 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 19.3, E-value 0.00087 282459006713 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 282459006714 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 282459006715 E3 interaction surface; other site 282459006716 lipoyl attachment site [posttranslational modification]; other site 282459006717 e3 binding domain; Region: E3_binding; pfam02817 282459006718 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 282459006719 Pfam match to entry PF00198 2-oxoacid_dh, 2-oxoacid dehydrogenases acyltransferase (catalytic domain), score 432.6, E-value 3.6e-127 282459006720 Pfam match to entry PF02817 e3_binding, e3 binding domain, score 18.1, E-value 0.00033 282459006721 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme, score 103.7, E-value 3.8e-28 282459006722 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 282459006723 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 282459006724 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 282459006725 TPP-binding site [chemical binding]; other site 282459006726 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 282459006727 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 282459006728 Pfam match to entry PF02779 transket_pyr, Transketolase, pyridine binding domain, score 184.7, E-value 1.5e-52 282459006729 Pfam match to entry PF00676 E1_dehydrog, Dehydrogenase E1 component, score 188.9, E-value 8.7e-54 282459006730 Signal peptide predicted for SAS1357 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.387 between residues 39 and 40; signal peptide 282459006731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 282459006732 HAMP domain; Region: HAMP; pfam00672 282459006733 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282459006734 dimer interface [polypeptide binding]; other site 282459006735 phosphorylation site [posttranslational modification] 282459006736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459006737 ATP binding site [chemical binding]; other site 282459006738 Mg2+ binding site [ion binding]; other site 282459006739 G-X-G motif; other site 282459006740 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 114.5, E-value 2.1e-31 282459006741 Pfam match to entry PF00512 HisKA, His Kinase A (phosphoacceptor) domain, score 70.6, E-value 3.6e-18 282459006742 Pfam match to entry PF00672 HAMP, HAMP domain, score 41.8, E-value 1.6e-09 282459006743 2 probable transmembrane helices predicted for SAS1357 by TMHMM2.0 at aa 10-32 and 154-176 282459006744 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282459006745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459006746 active site 282459006747 phosphorylation site [posttranslational modification] 282459006748 intermolecular recognition site; other site 282459006749 dimerization interface [polypeptide binding]; other site 282459006750 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282459006751 DNA binding site [nucleotide binding] 282459006752 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 90.7, E-value 3e-24 282459006753 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 151.6, E-value 1.5e-42 282459006754 PS00217 Sugar transport proteins signature 2. 282459006755 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 282459006756 Signal peptide predicted for SAS1359 by SignalP 2.0 HMM (Signal peptide probabilty 0.752) with cleavage site probability 0.331 between residues 30 and 31; signal peptide 282459006757 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 282459006758 active site 282459006759 Pfam match to entry PF01569 PAP2, PAP2 superfamily, score 109.9, E-value 5.2e-30 282459006760 6 probable transmembrane helices predicted for SAS1359 by TMHMM2.0 at aa 7-24, 58-77, 84-101, 121-143, 150-172 and 176-198 282459006761 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 282459006762 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 282459006763 active site 282459006764 homodimer interface [polypeptide binding]; other site 282459006765 Pfam match to entry PF04101 Glyco_tran_28_C, Glycosyltransferase family 28 C-terminal domain, score 87.3, E-value 3.2e-23 282459006766 Pfam match to entry PF03033 Glyco_transf_28, Glycosyltransferase family 28 N-terminal domain, score 133.2, E-value 4.9e-37 282459006767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459006768 Coenzyme A binding pocket [chemical binding]; other site 282459006769 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 45.2, E-value 1.5e-10 282459006770 Probable gene remnant. Similar to SN-terminal regions of Staphylococcus aureus prophage phiPV83 transposase SWALL:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 4.3e-65, 92.81% id in 181 aa, and Bacillus halodurans cassette chromosome recombinase B1 bh0682 SWALL:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 5.5e-34, 49.17% id in 181 aa; transposase (fragment) 282459006771 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 282459006772 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 282459006773 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 282459006774 protein binding site [polypeptide binding]; other site 282459006775 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 282459006776 Catalytic dyad [active] 282459006777 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 282459006778 Pfam match to entry PF03572 Peptidase_S41, Peptidase family S41B, score 302.1, E-value 7.2e-88 282459006779 Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF), score 67.7, E-value 2.6e-17 282459006780 1 probable transmembrane helix predicted for SAS1363 by TMHMM2.0 at aa 39-61 282459006781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 282459006782 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 282459006783 HPr interaction site; other site 282459006784 glycerol kinase (GK) interaction site [polypeptide binding]; other site 282459006785 active site 282459006786 phosphorylation site [posttranslational modification] 282459006787 Pfam match to entry PF00358 PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1, score 212.2, E-value 8e-61 282459006788 PS00371 PTS EIIA domains phosphorylation site signature 1. 282459006789 methionine sulfoxide reductase B; Provisional; Region: PRK00222 282459006790 SelR domain; Region: SelR; pfam01641 282459006791 Pfam match to entry PF01641 SelR, SelR domain, score 250.8, E-value 2e-72 282459006792 methionine sulfoxide reductase A; Provisional; Region: PRK13014 282459006793 Pfam match to entry PF01625 PMSR, Peptide methionine sulfoxide reductase, score 264.9, E-value 1.1e-76 282459006794 EDD domain protein, DegV family; Region: DegV; TIGR00762 282459006795 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 282459006796 Pfam match to entry PF02645 DUF194, Uncharacterized protein, DegV family COG1307, score 262.9, E-value 4.5e-76 282459006797 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 282459006798 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 282459006799 folate binding site [chemical binding]; other site 282459006800 NADP+ binding site [chemical binding]; other site 282459006801 Pfam match to entry PF00186 DiHfolate_red, Dihydrofolate reductase, score 214.8, E-value 1.3e-61 282459006802 PS00075 Dihydrofolate reductase signature. 282459006803 thymidylate synthase; Region: thym_sym; TIGR03284 282459006804 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 282459006805 dimerization interface [polypeptide binding]; other site 282459006806 active site 282459006807 Pfam match to entry PF00303 thymidylat_synt, Thymidylate synthase, score 605.9, E-value 2.5e-179 282459006808 PS00091 Thymidylate synthase active site. 282459006809 Disulphide isomerase; Region: Disulph_isomer; pfam06491 282459006810 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 282459006811 Virulence factor; Region: Virulence_fact; pfam13769 282459006812 HEAT repeats; Region: HEAT_2; pfam13646 282459006813 HEAT repeat; Region: HEAT; pfam02985 282459006814 Pfam match to entry PF03130 HEAT_PBS, PBS lyase HEAT-like repeat, score 18.9, E-value 0.013 282459006815 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 282459006816 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 282459006817 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 282459006818 7 probable transmembrane helices predicted for SAS1375 by TMHMM2.0 at aa 5-22, 29-46, 51-73, 86-108, 128-150, 170-192 and 196-218 282459006819 Pfam match to entry PF02592 DUF165, Uncharacterized ACR, YhhQ family COG1738, score 269.4, E-value 4.8e-78 282459006820 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 282459006821 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 282459006822 RNA/DNA hybrid binding site [nucleotide binding]; other site 282459006823 active site 282459006824 Pfam match to entry PF00075 rnaseH, RNase H, score 6.6, E-value 6.7e-05 282459006825 Ortholog of S. aureus MRSA252 (BX571856) SAR1447; Similar to Staphylococcus aureus ebh protein Ebh or MW1324 SWALL:Q8NWQ6 (EMBL:AP004826) (9904 aa) fasta scores: E(): 0, 78.77% id in 10547 aa. CDS contain an internal deletion and frameshift after codon 7082. CDS also contains additional residues after codon 4045;very large surface anchored protein (pseudogene) 282459006826 1 probable transmembrane helix predicted for SAS1377 by TMHMM2.0 at aa 8760-8782 282459006827 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 1.6, E-value 1.2e+02 282459006828 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 1.2, E-value 1.5e+02 282459006829 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 0.3, E-value 2.5e+02 282459006830 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 0.3, E-value 2.5e+02 282459006831 Pfam match to entry PF01468 GA, GA module, score 21.2, E-value 4.4e-05 282459006832 Pfam match to entry PF01468 GA, GA module, score 64.8, E-value 2e-16 282459006833 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 3.6, E-value 36 282459006834 Pfam match to entry PF01468 GA, GA module, score 65.5, E-value 1.2e-16 282459006835 Pfam match to entry PF01468 GA, GA module, score 69.0, E-value 1e-17 282459006836 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 0.2, E-value 2.7e+02 282459006837 Pfam match to entry PF01468 GA, GA module, score 63.2, E-value 5.7e-16 282459006838 Pfam match to entry PF01468 GA, GA module, score 64.3, E-value 2.7e-16 282459006839 Pfam match to entry PF01468 GA, GA module, score 71.7, E-value 1.6e-18 282459006840 Pfam match to entry PF01468 GA, GA module, score 66.0, E-value 8.3e-17 282459006841 Pfam match to entry PF01468 GA, GA module, score 13.4, E-value 0.0063 282459006842 Pfam match to entry PF01468 GA, GA module, score 63.9, E-value 3.5e-16 282459006843 Pfam match to entry PF01468 GA, GA module, score 63.5, E-value 4.7e-16 282459006844 Pfam match to entry PF01468 GA, GA module, score 62.6, E-value 8.9e-16 282459006845 Pfam match to entry PF01468 GA, GA module, score 75.6, E-value 1.1e-19 282459006846 Pfam match to entry PF01468 GA, GA module, score 83.0, E-value 6.4e-22 282459006847 Pfam match to entry PF01468 GA, GA module, score 79.2, E-value 9.2e-21 282459006848 Pfam match to entry PF01468 GA, GA module, score 70.3, E-value 4.4e-18 282459006849 Pfam match to entry PF01468 GA, GA module, score 64.0, E-value 3.4e-16 282459006850 Pfam match to entry PF01468 GA, GA module, score 74.0, E-value 3.4e-19 282459006851 Pfam match to entry PF01468 GA, GA module, score 71.3, E-value 2.1e-18 282459006852 Pfam match to entry PF01468 GA, GA module, score 67.6, E-value 2.8e-17 282459006853 Pfam match to entry PF01468 GA, GA module, score 70.7, E-value 3.2e-18 282459006854 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 0.4, E-value 2.4e+02 282459006855 Pfam match to entry PF01468 GA, GA module, score 60.5, E-value 3.7e-15 282459006856 Pfam match to entry PF01468 GA, GA module, score 72.9, E-value 6.8e-19 282459006857 Pfam match to entry PF01468 GA, GA module, score 63.4, E-value 5.2e-16 282459006858 Pfam match to entry PF01468 GA, GA module, score 70.4, E-value 3.9e-18 282459006859 Pfam match to entry PF01468 GA, GA module, score 63.2, E-value 5.7e-16 282459006860 Pfam match to entry PF01468 GA, GA module, score 72.1, E-value 1.2e-18 282459006861 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 1.1, E-value 1.6e+02 282459006862 Pfam match to entry PF01468 GA, GA module, score 77.2, E-value 3.6e-20 282459006863 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 1.7, E-value 1.1e+02 282459006864 Pfam match to entry PF01468 GA, GA module, score 64.7, E-value 2e-16 282459006865 Pfam match to entry PF01468 GA, GA module, score 64.3, E-value 2.8e-16 282459006866 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 1.4, E-value 1.4e+02 282459006867 Pfam match to entry PF01468 GA, GA module, score 63.4, E-value 5e-16 282459006868 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 2.2, E-value 82 282459006869 Pfam match to entry PF01468 GA, GA module, score 68.2, E-value 1.8e-17 282459006870 Pfam match to entry PF01468 GA, GA module, score 71.0, E-value 2.6e-18 282459006871 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 1.1, E-value 1.6e+02 282459006872 Pfam match to entry PF01468 GA, GA module, score 59.6, E-value 7.2e-15 282459006873 Pfam match to entry PF01468 GA, GA module, score 55.7, E-value 1e-13 282459006874 Pfam match to entry PF01468 GA, GA module, score 74.8, E-value 1.9e-19 282459006875 Pfam match to entry PF01468 GA, GA module, score 68.3, E-value 1.7e-17 282459006876 Pfam match to entry PF01468 GA, GA module, score 72.2, E-value 1.1e-18 282459006877 Pfam match to entry PF01468 GA, GA module, score 71.6, E-value 1.7e-18 282459006878 Pfam match to entry PF01468 GA, GA module, score 64.1, E-value 3.1e-16 282459006879 Pfam match to entry PF01468 GA, GA module, score 66.9, E-value 4.5e-17 282459006880 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 2.6, E-value 67 282459006881 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 2.4, E-value 76 282459006882 Pfam match to entry PF00904 Involucrin, Involucrin repeat, score 0.5, E-value 2.3e+02 282459006883 Signal peptide predicted for SAS1377 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 39 and 40 282459006884 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 45.5, E-value 1.2e-10 282459006885 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 282459006886 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -98.8, E-value 0.001 282459006887 14 probable transmembrane helices predicted for SAS1379 by TMHMM2.0 at aa 13-35, 50-72, 85-107, 111-133, 140-162, 166-185, 205-221, 231-250, 271-293, 303-322, 334-353, 357-379, 400-422 and 432-454 282459006888 Signal peptide predicted for SAS1380 by SignalP 2.0 HMM (Signal peptide probabilty 0.758) with cleavage site probability 0.388 between residues 32 and 33; signal peptide 282459006889 Amino acid permease; Region: AA_permease_2; pfam13520 282459006890 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score 124.7, E-value 1.8e-34 282459006891 12 probable transmembrane helices predicted for SAS1380 by TMHMM2.0 at aa 12-34, 49-71, 91-113, 123-145, 152-174, 194-216, 229-251, 282-299, 327-349, 353-375, 388-407 and 411-433 282459006892 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 282459006893 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 282459006894 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 282459006895 tetramer interface [polypeptide binding]; other site 282459006896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459006897 catalytic residue [active] 282459006898 Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme, score 294.5, E-value 1.4e-85 282459006899 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 282459006900 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 282459006901 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 282459006902 hexamer interface [polypeptide binding]; other site 282459006903 ligand binding site [chemical binding]; other site 282459006904 putative active site [active] 282459006905 NAD(P) binding site [chemical binding]; other site 282459006906 Pfam match to entry PF01262 AlaDh_PNT_C, Alanine dehydrogenase/PNT, C-terminal domain, score 300.6, E-value 2e-87 282459006907 Pfam match to entry PF05222 AlaDh_PNT_N, Alanine dehydrogenase/PNT, N-terminal domain, score 229.8, E-value 4e-66 282459006908 5'-3' exonuclease; Region: 53EXOc; smart00475 282459006909 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 282459006910 active site 282459006911 metal binding site 1 [ion binding]; metal-binding site 282459006912 putative 5' ssDNA interaction site; other site 282459006913 metal binding site 3; metal-binding site 282459006914 metal binding site 2 [ion binding]; metal-binding site 282459006915 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 282459006916 putative DNA binding site [nucleotide binding]; other site 282459006917 putative metal binding site [ion binding]; other site 282459006918 Pfam match to entry PF01367 5_3_exonuclease, 5'-3' exonuclease, C-terminal SAM fold, score 123.7, E-value 3.6e-34 282459006919 Pfam match to entry PF02739 5_3_exonuc_N, 5'-3' exonuclease, N-terminal resolvase-like domain, score 248.6, E-value 9.3e-72 282459006920 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 282459006921 Dynamin family; Region: Dynamin_N; pfam00350 282459006922 G1 box; other site 282459006923 GTP/Mg2+ binding site [chemical binding]; other site 282459006924 G2 box; other site 282459006925 Switch I region; other site 282459006926 G3 box; other site 282459006927 Switch II region; other site 282459006928 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 282459006929 G4 box; other site 282459006930 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 282459006931 Dynamin family; Region: Dynamin_N; pfam00350 282459006932 G1 box; other site 282459006933 GTP/Mg2+ binding site [chemical binding]; other site 282459006934 G2 box; other site 282459006935 Switch I region; other site 282459006936 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 282459006937 G3 box; other site 282459006938 Switch II region; other site 282459006939 GTP/Mg2+ binding site [chemical binding]; other site 282459006940 G4 box; other site 282459006941 G5 box; other site 282459006942 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006943 PS00017 ATP/GTP-binding site motif A (P-loop). 282459006944 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 282459006945 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 282459006946 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 282459006947 Pfam match to entry PF03929 DUF337, Uncharacterized iron-regulated membrane protein (DUF337), score 430.0, E-value 2.2e-126 282459006948 5 probable transmembrane helices predicted for SAS1385 by TMHMM2.0 at aa 15-37, 139-161, 181-203, 366-387 and 407-438 282459006949 Signal peptide predicted for SAS1386 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.398 between residues 29 and 30; signal peptide 282459006950 Cobalt transport protein component CbiN; Region: CbiN; cl00842 282459006951 1 probable transmembrane helix predicted for SAS1386 by TMHMM2.0 at aa 5-27 282459006952 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 282459006953 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 282459006954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 282459006955 Pfam match to entry PF01170 UPF0020, RNA methylase family UPF0020, score 233.2, E-value 3.9e-67 282459006956 PS00092 N-6 Adenine-specific DNA methylases signature. 282459006957 PS01261 Uncharacterized protein family UPF0020 signature. 282459006958 cell division protein GpsB; Provisional; Region: PRK14127 282459006959 DivIVA domain; Region: DivI1A_domain; TIGR03544 282459006960 Pfam match to entry PF05103 DivIVA, DivIVA protein, score 12.5, E-value 4.8e-09 282459006961 hypothetical protein; Provisional; Region: PRK13660 282459006962 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 282459006963 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 282459006964 Pfam match to entry PF03838 RecU, Recombination protein U, score 406.9, E-value 2e-119 282459006965 Signal peptide predicted for SAS1393 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.664 between residues 60 and 61; signal peptide 282459006966 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 282459006967 Transglycosylase; Region: Transgly; pfam00912 282459006968 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 282459006969 1 probable transmembrane helix predicted for SAS1393 by TMHMM2.0 at aa 35-57 282459006970 Pfam match to entry PF00912 Transglycosyl, Transglycosylase, score 353.3, E-value 2.8e-103 282459006971 Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain, score 77.7, E-value 2.5e-20 282459006972 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 282459006973 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 282459006974 minor groove reading motif; other site 282459006975 helix-hairpin-helix signature motif; other site 282459006976 substrate binding pocket [chemical binding]; other site 282459006977 active site 282459006978 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 282459006979 PS00764 Endonuclease III iron-sulfur binding region signature. 282459006980 Pfam match to entry PF00730 HhH-GPD, HhH-GPD superfamily base excision DNA repair protein, score 80.6, E-value 3.3e-21 282459006981 Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif, score 29.7, E-value 7.3e-06 282459006982 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 282459006983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 282459006984 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 282459006985 Pfam match to entry PF04271 DnaD, DnaD-like domain, score 132.8, E-value 6.7e-37 282459006986 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 282459006987 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 282459006988 putative dimer interface [polypeptide binding]; other site 282459006989 putative anticodon binding site; other site 282459006990 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 282459006991 homodimer interface [polypeptide binding]; other site 282459006992 motif 1; other site 282459006993 motif 2; other site 282459006994 active site 282459006995 motif 3; other site 282459006996 Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N), score 294.5, E-value 1.4e-85 282459006997 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 282459006998 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain, score 80.7, E-value 3.2e-21 282459006999 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 282459007000 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 282459007001 active site 282459007002 catalytic site [active] 282459007003 substrate binding site [chemical binding]; other site 282459007004 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 282459007005 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 282459007006 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007007 Pfam match to entry PF00929 Exonuclease, Exonuclease, score 102.0, E-value 1.2e-27 282459007008 Biotin operon repressor [Transcription]; Region: BirA; COG1654 282459007009 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 282459007010 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 282459007011 Pfam match to entry PF03099 BPL_LipA_LipB, Biotin/lipoate A/B protein ligase family, score 91.1, E-value 2.4e-24 282459007012 Predicted helix-turn-helix motif for SAS1399 with score 1321.000, SD 3.69 at aa 20-41, sequence ISGQSIAESLNISRTAVKKVID 282459007013 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 282459007014 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 282459007015 active site 282459007016 NTP binding site [chemical binding]; other site 282459007017 metal binding triad [ion binding]; metal-binding site 282459007018 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 282459007019 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 282459007020 Pfam match to entry PF01743 PolyA_pol, Poly A polymerase family, score 160.1, E-value 3.9e-45 282459007021 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 282459007022 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 282459007023 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 143.9, E-value 3.1e-40 282459007024 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 282459007025 homodimer interface [polypeptide binding]; other site 282459007026 metal binding site [ion binding]; metal-binding site 282459007027 Pfam match to entry PF03819 MazG, MazG nucleotide pyrophosphohydrolase domain, score 96.8, E-value 4.5e-26 282459007028 Signal peptide predicted for SAS1403 by SignalP 2.0 HMM (Signal peptide probabilty 0.678) with cleavage site probability 0.371 between residues 21 and 22; signal peptide 282459007029 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 282459007030 Pfam match to entry PF04298 Zn_peptidase_2, neutral zinc metallopeptidase, score 578.5, E-value 4.3e-171 282459007031 4 probable transmembrane helices predicted for SAS1403 by TMHMM2.0 at aa 4-21, 119-141, 151-173 and 202-224 282459007032 PS00107 Protein kinases ATP-binding region signature. 282459007033 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282459007034 Predicted membrane protein [Function unknown]; Region: COG4347 282459007035 6 probable transmembrane helices predicted for SAS1404 by TMHMM2.0 at aa 13-35, 50-69, 78-100, 105-127, 134-156 and 166-188 282459007036 Uncharacterized conserved protein [Function unknown]; Region: COG5582 282459007037 UPF0302 domain; Region: UPF0302; pfam08864 282459007038 A short protein domain of unknown function; Region: IDEAL; smart00914 282459007039 TPR repeat; Region: TPR_11; pfam13414 282459007040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 282459007041 binding surface 282459007042 TPR motif; other site 282459007043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 282459007044 TPR motif; other site 282459007045 binding surface 282459007046 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 282459007047 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 282459007048 hinge; other site 282459007049 active site 282459007050 Pfam match to entry PF00275 EPSP_synthase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase), score 596.2, E-value 2.1e-176 282459007051 PS00104 EPSP synthase signature 1. 282459007052 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 282459007053 active site 282459007054 NAD binding site [chemical binding]; other site 282459007055 metal binding site [ion binding]; metal-binding site 282459007056 Pfam match to entry PF01761 DHQ_synthase, 3-dehydroquinate synthase, score 249.3, E-value 5.4e-72 282459007057 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 282459007058 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 282459007059 Tetramer interface [polypeptide binding]; other site 282459007060 active site 282459007061 FMN-binding site [chemical binding]; other site 282459007062 Pfam match to entry PF01264 Chorismate_synt, Chorismate synthase, score 783.3, E-value 9.6e-233 282459007063 PS00789 Chorismate synthase signature 3. 282459007064 PS00788 Chorismate synthase signature 2. 282459007065 PS00787 Chorismate synthase signature 1. 282459007066 2 probable transmembrane helices predicted for SAS1409a by TMHMM2.0 at aa 5-27 and 37-58 282459007067 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 282459007068 active site 282459007069 multimer interface [polypeptide binding]; other site 282459007070 Pfam match to entry PF00334 NDK, Nucleoside diphosphate kinase, score 308.8, E-value 6.9e-90 282459007071 PS00469 Nucleoside diphosphate kinases active site. 282459007072 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 282459007073 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 282459007074 substrate binding pocket [chemical binding]; other site 282459007075 chain length determination region; other site 282459007076 substrate-Mg2+ binding site; other site 282459007077 catalytic residues [active] 282459007078 aspartate-rich region 1; other site 282459007079 active site lid residues [active] 282459007080 aspartate-rich region 2; other site 282459007081 Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetase, score 266.1, E-value 4.9e-77 282459007082 PS00444 Polyprenyl synthetases signature 2. 282459007083 PS00723 Polyprenyl synthetases signature 1. 282459007084 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 282459007085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459007086 S-adenosylmethionine binding site [chemical binding]; other site 282459007087 Pfam match to entry PF01209 Ubie_methyltran, ubiE/COQ5 methyltransferase family, score 429.5, E-value 3.2e-126 282459007088 PS01184 ubiE/COQ5 methyltransferase family signature 2. 282459007089 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 282459007090 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 282459007091 IHF dimer interface [polypeptide binding]; other site 282459007092 IHF - DNA interface [nucleotide binding]; other site 282459007093 Pfam match to entry PF00216 Bac_DNA_binding, Bacterial DNA-binding protein, score 194.9, E-value 1.4e-55 282459007094 PS00045 Bacterial histone-like DNA-binding proteins signature. 282459007095 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 282459007096 Signal peptide predicted for SAS1415 by SignalP 2.0 HMM (Signal peptide probabilty 0.866) with cleavage site probability 0.757 between residues 21 and 22; signal peptide 282459007097 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 282459007098 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 282459007099 Pfam match to entry PF01210 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase, score 477.1, E-value 1.4e-140 282459007100 GTP-binding protein Der; Reviewed; Region: PRK00093 282459007101 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 282459007102 G1 box; other site 282459007103 GTP/Mg2+ binding site [chemical binding]; other site 282459007104 Switch I region; other site 282459007105 G2 box; other site 282459007106 Switch II region; other site 282459007107 G3 box; other site 282459007108 G4 box; other site 282459007109 G5 box; other site 282459007110 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 282459007111 G1 box; other site 282459007112 GTP/Mg2+ binding site [chemical binding]; other site 282459007113 Switch I region; other site 282459007114 G2 box; other site 282459007115 G3 box; other site 282459007116 Switch II region; other site 282459007117 G4 box; other site 282459007118 G5 box; other site 282459007119 Pfam match to entry PF01926 MMR_HSR1, GTPase of unknown function, score 216.1, E-value 5.7e-62 282459007120 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007121 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007122 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 282459007123 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 282459007124 RNA binding site [nucleotide binding]; other site 282459007125 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 282459007126 RNA binding site [nucleotide binding]; other site 282459007127 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 282459007128 RNA binding site [nucleotide binding]; other site 282459007129 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 282459007130 RNA binding site [nucleotide binding]; other site 282459007131 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 97.9, E-value 2.1e-26 282459007132 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 107.1, E-value 3.6e-29 282459007133 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 65.5, E-value 1.2e-16 282459007134 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 59.0, E-value 1.1e-14 282459007135 cytidylate kinase; Provisional; Region: cmk; PRK00023 282459007136 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 282459007137 CMP-binding site; other site 282459007138 The sites determining sugar specificity; other site 282459007139 Pfam match to entry PF02224 Cytidylate_kin, Cytidylate kinase, score 230.2, E-value 3.2e-66 282459007140 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007141 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 282459007142 active site 282459007143 homotetramer interface [polypeptide binding]; other site 282459007144 homodimer interface [polypeptide binding]; other site 282459007145 PS00144 Asparaginase / glutaminase active site signature 1. 282459007146 Pfam match to entry PF00710 Asparaginase, Asparaginase, score 223.3, E-value 3.8e-64 282459007147 PS00917 Asparaginase / glutaminase active site signature 2. 282459007148 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 282459007149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 282459007150 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282459007151 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 35.4, E-value 1.6e-08 282459007152 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 282459007153 Pfam match to entry PF01476 LysM, LysM domain, score 32.4, E-value 1.1e-06 282459007154 1 probable transmembrane helix predicted for SAS1421 by TMHMM2.0 at aa 320-342 282459007155 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 282459007156 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282459007157 ATP binding site [chemical binding]; other site 282459007158 putative Mg++ binding site [ion binding]; other site 282459007159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282459007160 nucleotide binding region [chemical binding]; other site 282459007161 ATP-binding site [chemical binding]; other site 282459007162 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 99.0, E-value 9.5e-27 282459007163 Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase, score 109.6, E-value 6.4e-30 282459007164 PS00690 DEAH-box subfamily ATP-dependent helicases signature. 282459007165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 282459007166 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 282459007167 Predicted membrane protein [Function unknown]; Region: COG3601 282459007168 Signal peptide predicted for SAS1425 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.447 between residues 59 and 60; signal peptide 282459007169 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 282459007170 5 probable transmembrane helices predicted for SAS1425 by TMHMM2.0 at aa 7-29, 44-66, 78-95, 105-127 and 147-169 282459007171 Signal peptide predicted for SAS1426 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.531 between residues 26 and 27; signal peptide 282459007172 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 282459007173 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459007174 Signal peptide predicted for SAS1427 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.455 between residues 26 and 27; signal peptide 282459007175 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 282459007176 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459007177 Signal peptide predicted for SAS1428 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.455 between residues 26 and 27; signal peptide 282459007178 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 282459007179 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459007180 Signal peptide predicted for SAS1430 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.526 between residues 27 and 28; signal peptide 282459007181 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 282459007182 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459007183 Signal peptide predicted for SAS1431 by SignalP 2.0 HMM (Signal peptide probabilty 0.938) with cleavage site probability 0.357 between residues 51 and 52; signal peptide 282459007184 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 282459007185 dimerization interface [polypeptide binding]; other site 282459007186 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 282459007187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282459007188 dimer interface [polypeptide binding]; other site 282459007189 phosphorylation site [posttranslational modification] 282459007190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459007191 ATP binding site [chemical binding]; other site 282459007192 Mg2+ binding site [ion binding]; other site 282459007193 G-X-G motif; other site 282459007194 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 147.8, E-value 2e-41 282459007195 Pfam match to entry PF00512 HisKA, His Kinase A (phosphoacceptor) domain, score 80.2, E-value 4.4e-21 282459007196 Pfam match to entry PF00672 HAMP, HAMP domain, score 83.9, E-value 3.4e-22 282459007197 2 probable transmembrane helices predicted for SAS1431 by TMHMM2.0 at aa 15-37 and 178-200 282459007198 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282459007199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459007200 active site 282459007201 phosphorylation site [posttranslational modification] 282459007202 intermolecular recognition site; other site 282459007203 dimerization interface [polypeptide binding]; other site 282459007204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282459007205 DNA binding site [nucleotide binding] 282459007206 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 91.1, E-value 2.3e-24 282459007207 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 142.6, E-value 7.2e-40 282459007208 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 282459007209 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 282459007210 RNA binding surface [nucleotide binding]; other site 282459007211 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 282459007212 active site 282459007213 Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase, score 87.0, E-value 4e-23 282459007214 PS01149 Rsu family of pseudouridine synthase signature. 282459007215 Pfam match to entry PF01479 S4, S4 domain, score 56.7, E-value 5.4e-14 282459007216 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 282459007217 Pfam match to entry PF04079 DUF387, transcriptional regulators (Ypuh-like), score 246.6, E-value 3.6e-71 282459007218 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 282459007219 Pfam match to entry PF02616 DUF173, Uncharacterised ACR, COG1354, score 113.0, E-value 5.9e-31 282459007220 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 282459007221 Pfam match to entry PF03745 DUF309, Domain of unknown function (DUF309), score 33.1, E-value 6.5e-07 282459007222 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 282459007223 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 282459007224 active site 282459007225 Int/Topo IB signature motif; other site 282459007226 Pfam match to entry PF00589 Phage_integrase, Phage integrase family, score 219.6, E-value 4.8e-63 282459007227 Pfam match to entry PF02899 Phage_integr_N, Phage integrase, N-terminal SAM-like domain, score 124.1, E-value 2.7e-34 282459007228 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 282459007229 metal binding site 2 [ion binding]; metal-binding site 282459007230 putative DNA binding helix; other site 282459007231 metal binding site 1 [ion binding]; metal-binding site 282459007232 dimer interface [polypeptide binding]; other site 282459007233 structural Zn2+ binding site [ion binding]; other site 282459007234 Pfam match to entry PF01475 FUR, Ferric uptake regulator family, score 184.7, E-value 1.6e-52 282459007235 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 282459007236 dimer interface [polypeptide binding]; other site 282459007237 ADP-ribose binding site [chemical binding]; other site 282459007238 active site 282459007239 nudix motif; other site 282459007240 metal binding site [ion binding]; metal-binding site 282459007241 Pfam match to entry PF00293 NUDIX, NUDIX domain, score 84.4, E-value 2.5e-22 282459007242 PS00893 mutT domain signature. 282459007243 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 282459007244 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 282459007245 active site 282459007246 catalytic tetrad [active] 282459007247 Pfam match to entry PF00248 aldo_ket_red, Aldo/keto reductase family, score 60.3, E-value 4.5e-15 282459007248 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 282459007249 classical (c) SDRs; Region: SDR_c; cd05233 282459007250 NAD(P) binding site [chemical binding]; other site 282459007251 active site 282459007252 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 46.4, E-value 1.6e-11 282459007253 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 282459007254 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 282459007255 Pfam match to entry PF01089 P5CR, Delta 1-pyrroline-5-carboxylate reductase, score 203.1, E-value 4.4e-58 282459007256 ribonuclease Z; Region: RNase_Z; TIGR02651 282459007257 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 29.8, E-value 8.5e-08 282459007258 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 282459007259 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 282459007260 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 282459007261 Pfam match to entry PF00479 G6PD, Glucose-6-phosphate dehydrogenase, NAD binding domain, score 269.8, E-value 3.6e-78 282459007262 Pfam match to entry PF02781 G6PD_C, Glucose-6-phosphate dehydrogenase, C-terminal domain, score 451.4, E-value 8e-133 282459007263 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 282459007264 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 282459007265 PS00041 Bacterial regulatory proteins, araC family signature. 282459007266 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 26.6, E-value 6.3e-05 282459007267 Predicted helix-turn-helix motif for SAS1446 with score 1399.000, SD 3.95 at aa 22-43, sequence FNLQELSDYVGLSPYHLDQSFK 282459007268 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 2.3, E-value 1.6 282459007269 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 282459007270 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 282459007271 Ca binding site [ion binding]; other site 282459007272 active site 282459007273 catalytic site [active] 282459007274 Pfam match to entry PF00128 alpha-amylase, Alpha amylase, catalytic domain, score 383.6, E-value 2.1e-112 282459007275 Transcriptional regulators [Transcription]; Region: PurR; COG1609 282459007276 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 282459007277 DNA binding site [nucleotide binding] 282459007278 domain linker motif; other site 282459007279 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 282459007280 putative ligand binding site [chemical binding]; other site 282459007281 putative dimerization interface [polypeptide binding]; other site 282459007282 Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family, score 67.8, E-value 2.5e-17 282459007283 Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, score 46.7, E-value 5.3e-11 282459007284 Predicted helix-turn-helix motif for SAS1448 with score 2503.000, SD 7.71 at aa 2-23, sequence VTIKDVALKAGVSPSTVSRVIK 282459007285 PS00356 Bacterial regulatory proteins, lacI family signature. 282459007286 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 282459007287 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 282459007288 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 35.9, E-value 9.7e-08 282459007289 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 282459007290 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 282459007291 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 282459007292 Pfam match to entry PF00393 6PGD, 6-phosphogluconate dehydrogenase, C-terminal domain, score 717.8, E-value 5.1e-213 282459007293 PS00461 6-phosphogluconate dehydrogenase signature. 282459007294 Pfam match to entry PF03446 NAD_binding_2, NAD binding domain of 6-phosphogluconate dehydrogenase, score 373.7, E-value 2e-109 282459007295 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 282459007296 peptidase T-like protein; Region: PepT-like; TIGR01883 282459007297 metal binding site [ion binding]; metal-binding site 282459007298 putative dimer interface [polypeptide binding]; other site 282459007299 Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40, score 265.8, E-value 6.1e-77 282459007300 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 282459007301 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 282459007302 Predicted membrane protein [Function unknown]; Region: COG4129 282459007303 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 282459007304 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 282459007305 Pfam match to entry PF06081 DUF939, Bacterial protein of unknown function (DUF939), score 568.4, E-value 4.9e-168 282459007306 4 probable transmembrane helices predicted for SAS1452 by TMHMM2.0 at aa 22-44, 57-79, 83-105 and 125-147 282459007307 Disulphide isomerase; Region: Disulph_isomer; pfam06491 282459007308 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 282459007309 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 282459007310 E3 interaction surface; other site 282459007311 lipoyl attachment site [posttranslational modification]; other site 282459007312 e3 binding domain; Region: E3_binding; pfam02817 282459007313 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 282459007314 Pfam match to entry PF00198 2-oxoacid_dh, 2-oxoacid dehydrogenases acyltransferase (catalytic domain), score 424.3, E-value 1.2e-124 282459007315 Pfam match to entry PF02817 e3_binding, e3 binding domain, score 48.5, E-value 1.6e-11 282459007316 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme, score 101.8, E-value 1.4e-27 282459007317 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 282459007318 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 282459007319 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 282459007320 alpha subunit interface [polypeptide binding]; other site 282459007321 TPP binding site [chemical binding]; other site 282459007322 heterodimer interface [polypeptide binding]; other site 282459007323 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 282459007324 Pfam match to entry PF02780 transketolase_C, Transketolase, C-terminal domain, score 173.0, E-value 5.1e-49 282459007325 Pfam match to entry PF02779 transket_pyr, Transketolase, pyridine binding domain, score 249.3, E-value 5.4e-72 282459007326 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 282459007327 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 282459007328 tetramer interface [polypeptide binding]; other site 282459007329 TPP-binding site [chemical binding]; other site 282459007330 heterodimer interface [polypeptide binding]; other site 282459007331 phosphorylation loop region [posttranslational modification] 282459007332 Pfam match to entry PF00676 E1_dehydrog, Dehydrogenase E1 component, score 364.0, E-value 1.7e-106 282459007333 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 282459007334 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 282459007335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282459007336 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 282459007337 Pfam match to entry PF02852 pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 128.5, E-value 1.3e-35 282459007338 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 287.6, E-value 1.6e-83 282459007339 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 282459007340 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 282459007341 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 282459007342 Walker A/P-loop; other site 282459007343 ATP binding site [chemical binding]; other site 282459007344 Q-loop/lid; other site 282459007345 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 282459007346 ABC transporter signature motif; other site 282459007347 Walker B; other site 282459007348 D-loop; other site 282459007349 H-loop/switch region; other site 282459007350 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007351 arginine repressor; Provisional; Region: PRK04280 282459007352 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 282459007353 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 282459007354 Pfam match to entry PF02863 Arg_repressor_C, Arginine repressor, C-terminal domain, score 113.7, E-value 3.6e-31 282459007355 Pfam match to entry PF01316 Arg_repressor, Arginine repressor, DNA binding domain, score 114.6, E-value 2e-31 282459007356 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 282459007357 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 282459007358 substrate binding pocket [chemical binding]; other site 282459007359 chain length determination region; other site 282459007360 substrate-Mg2+ binding site; other site 282459007361 catalytic residues [active] 282459007362 aspartate-rich region 1; other site 282459007363 active site lid residues [active] 282459007364 aspartate-rich region 2; other site 282459007365 Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetase, score 306.4, E-value 3.7e-89 282459007366 PS00444 Polyprenyl synthetases signature 2. 282459007367 PS00723 Polyprenyl synthetases signature 1. 282459007368 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 282459007369 Pfam match to entry PF02609 Exonuc_VII_S, Exonuclease VII small subunit, score 120.2, E-value 3.9e-33 282459007370 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 282459007371 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 282459007372 generic binding surface II; other site 282459007373 generic binding surface I; other site 282459007374 Pfam match to entry PF02601 Exonuc_VII_L, Exonuclease VII, large subunit, score 207.4, E-value 2.2e-59 282459007375 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain, score 41.3, E-value 2.3e-09 282459007376 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 282459007377 putative RNA binding site [nucleotide binding]; other site 282459007378 Pfam match to entry PF01029 NusB, NusB family, score 115.2, E-value 1.3e-31 282459007379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 282459007380 Pfam match to entry PF03780 DUF322, Protein of unknown function (DUF322), score 94.3, E-value 2.5e-25 282459007381 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 282459007382 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 282459007383 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 282459007384 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 282459007385 Pfam match to entry PF02785 Biotin_carb_C, Biotin carboxylase C-terminal domain, score 201.6, E-value 1.3e-57 282459007386 Pfam match to entry PF02786 CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain, score 384.0, E-value 1.5e-112 282459007387 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 282459007388 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 282459007389 Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase L chain, N-terminal domain, score 163.1, E-value 4.8e-46 282459007390 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 282459007391 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 282459007392 carboxyltransferase (CT) interaction site; other site 282459007393 biotinylation site [posttranslational modification]; other site 282459007394 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme, score 114.8, E-value 1.8e-31 282459007395 elongation factor P; Validated; Region: PRK00529 282459007396 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 282459007397 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 282459007398 RNA binding site [nucleotide binding]; other site 282459007399 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 282459007400 RNA binding site [nucleotide binding]; other site 282459007401 Pfam match to entry PF01132 EFP, Elongation factor P (EF-P), score 391.3, E-value 1e-114 282459007402 PS01275 Elongation factor P signature. 282459007403 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 282459007404 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 282459007405 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 282459007406 active site 282459007407 Pfam match to entry PF00557 Peptidase_M24, metallopeptidase family M24, score 263.5, E-value 3e-76 282459007408 PS00491 Aminopeptidase P and proline dipeptidase signature. 282459007409 Signal peptide predicted for SAS1469 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.484 between residues 27 and 28; signal peptide 282459007410 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 282459007411 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459007412 Signal peptide predicted for SAS1470 by SignalP 2.0 HMM (Signal peptide probabilty 0.826) with cleavage site probability 0.703 between residues 36 and 37; signal peptide 282459007413 2 probable transmembrane helices predicted for SAS1470 by TMHMM2.0 at aa 7-29 and 33-52 282459007414 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 282459007415 Pfam match to entry PF03099 BPL_LipA_LipB, Biotin/lipoate A/B protein ligase family, score 116.9, E-value 4.1e-32 282459007416 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 282459007417 active site residue [active] 282459007418 1 probable transmembrane helix predicted for SAS1472 by TMHMM2.0 at aa 4-21 282459007419 Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain, score 81.3, E-value 2.1e-21 282459007420 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 282459007421 tetramer interface [polypeptide binding]; other site 282459007422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459007423 catalytic residue [active] 282459007424 Pfam match to entry PF02347 GDC-P, Glycine cleavage system P-protein, score -298.2, E-value 0.0027 282459007425 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 282459007426 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 282459007427 tetramer interface [polypeptide binding]; other site 282459007428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459007429 catalytic residue [active] 282459007430 Pfam match to entry PF02347 GDC-P, Glycine cleavage system P-protein, score 684.1, E-value 7.3e-203 282459007431 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 282459007432 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 282459007433 Pfam match to entry PF01571 GCV_T, Glycine cleavage T-protein (aminomethyl transferase), score 396.6, E-value 2.6e-116 282459007434 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 282459007435 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 282459007436 ADP binding site [chemical binding]; other site 282459007437 magnesium binding site [ion binding]; other site 282459007438 putative shikimate binding site; other site 282459007439 Pfam match to entry PF01202 SKI, Shikimate kinase, score 133.4, E-value 4.3e-37 282459007440 PS01128 Shikimate kinase signature. 282459007441 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007442 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 282459007443 1 probable transmembrane helix predicted for SAS1477 by TMHMM2.0 at aa 29-51 282459007444 Signal peptide predicted for SAS1478 by SignalP 2.0 HMM (Signal peptide probabilty 0.784) with cleavage site probability 0.405 between residues 48 and 49; signal peptide 282459007445 1 probable transmembrane helix predicted for SAS1478 by TMHMM2.0 at aa 10-32 282459007446 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 282459007447 Signal peptide predicted for SAS1479 by SignalP 2.0 HMM (Signal peptide probabilty 0.890) with cleavage site probability 0.557 between residues 33 and 34; signal peptide 282459007448 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 282459007449 1 probable transmembrane helix predicted for SAS1479 by TMHMM2.0 at aa 7-29 282459007450 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 282459007451 Signal peptide predicted for SAS1480 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.508 between residues 36 and 37; signal peptide 282459007452 1 probable transmembrane helix predicted for SAS1480 by TMHMM2.0 at aa 10-32 282459007453 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 282459007454 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 282459007455 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 282459007456 Pfam match to entry PF00482 GSPII_F, Bacterial type II secretion system protein F domain, score 22.1, E-value 1.1e-10 282459007457 3 probable transmembrane helices predicted for SAS1481 by TMHMM2.0 at aa 123-145, 168-190 and 327-349 282459007458 Type II/IV secretion system protein; Region: T2SE; pfam00437 282459007459 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 282459007460 Walker A motif; other site 282459007461 ATP binding site [chemical binding]; other site 282459007462 Walker B motif; other site 282459007463 Pfam match to entry PF00437 GSPII_E, Type II/IV secretion system protein, score 170.5, E-value 3e-48 282459007464 PS00662 Bacterial type II secretion system protein E signature. 282459007465 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007466 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 282459007467 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 125.9, E-value 7.8e-35 282459007468 Uncharacterized conserved protein [Function unknown]; Region: COG0011 282459007469 Pfam match to entry PF01910 DUF77, Protein of unknown function DUF77, score 189.3, E-value 6.2e-54 282459007470 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 282459007471 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 282459007472 Pfam match to entry PF00480 ROK, ROK family, score 160.1, E-value 4e-45 282459007473 PS01125 ROK family signature. 282459007474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 282459007475 Pfam match to entry PF06014 DUF910, Bacterial protein of unknown function (DUF910), score 133.2, E-value 5e-37 282459007476 Rhomboid family; Region: Rhomboid; pfam01694 282459007477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 282459007478 binding surface 282459007479 TPR motif; other site 282459007480 Tetratricopeptide repeat; Region: TPR_16; pfam13432 282459007481 7 probable transmembrane helices predicted for SAS1487 by TMHMM2.0 at aa 156-178, 218-237, 242-259, 264-286, 293-312, 316-335 and 342-364 282459007482 PS00041 Bacterial regulatory proteins, araC family signature. 282459007483 Pfam match to entry PF01694 Rhomboid, Rhomboid family, score 176.1, E-value 5.9e-50 282459007484 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 282459007485 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 282459007486 Pfam match to entry PF01812 5-FTHF_cyc-lig, 5-formyltetrahydrofolate cyclo-ligase family, score 142.3, E-value 8.9e-40 282459007487 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 282459007488 Pfam match to entry PF00471 Ribosomal_L33, Ribosomal protein L33, score 94.1, E-value 2.9e-25 282459007489 PS00582 Ribosomal protein L33 signature. 282459007490 Signal peptide predicted for SAS1490 by SignalP 2.0 HMM (Signal peptide probabilty 0.839) with cleavage site probability 0.756 between residues 48 and 49; signal peptide 282459007491 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 282459007492 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 282459007493 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 282459007494 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 282459007495 Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain, score 211.9, E-value 9.9e-61 282459007496 Pfam match to entry PF03717 PBP_dimer, Penicillin-binding Protein dimerisation domain, score 132.5, E-value 8e-37 282459007497 1 probable transmembrane helix predicted for SAS1490 by TMHMM2.0 at aa 21-43 282459007498 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 282459007499 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 282459007500 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 282459007501 Pfam match to entry PF02777 sodfe_C, Iron/manganese superoxide dismutases, C-terminal domain, score 224.8, E-value 1.3e-64 282459007502 PS00088 Manganese and iron superoxide dismutases signature. 282459007503 Pfam match to entry PF00081 sodfe, Iron/manganese superoxide dismutases, alpha-hairpin domain, score 187.3, E-value 2.6e-53 282459007504 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 282459007505 metal binding site 2 [ion binding]; metal-binding site 282459007506 putative DNA binding helix; other site 282459007507 metal binding site 1 [ion binding]; metal-binding site 282459007508 dimer interface [polypeptide binding]; other site 282459007509 structural Zn2+ binding site [ion binding]; other site 282459007510 Pfam match to entry PF01475 FUR, Ferric uptake regulator family, score 160.3, E-value 3.4e-45 282459007511 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 282459007512 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282459007513 ABC-ATPase subunit interface; other site 282459007514 dimer interface [polypeptide binding]; other site 282459007515 putative PBP binding regions; other site 282459007516 Pfam match to entry PF00950 ABC-3, ABC 3 transport family, score 194.2, E-value 2.2e-55 282459007517 9 probable transmembrane helices predicted for SAS1493 by TMHMM2.0 at aa 10-32, 39-61, 66-85, 98-117, 137-159, 171-193, 197-219, 226-248 and 253-270 282459007518 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 282459007519 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 282459007520 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 200.7, E-value 2.4e-57 282459007521 PS00211 ABC transporters family signature. 282459007522 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007523 endonuclease IV; Provisional; Region: PRK01060 282459007524 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 282459007525 AP (apurinic/apyrimidinic) site pocket; other site 282459007526 DNA interaction; other site 282459007527 Metal-binding active site; metal-binding site 282459007528 Pfam match to entry PF01261 AP_endonuc_2, AP endonuclease family 2, score 320.6, E-value 1.9e-93 282459007529 PS00731 AP endonucleases family 2 signature 3. 282459007530 PS00729 AP endonucleases family 2 signature 1. 282459007531 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 282459007532 DEAD-like helicases superfamily; Region: DEXDc; smart00487 282459007533 ATP binding site [chemical binding]; other site 282459007534 putative Mg++ binding site [ion binding]; other site 282459007535 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282459007536 nucleotide binding region [chemical binding]; other site 282459007537 ATP-binding site [chemical binding]; other site 282459007538 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 102.9, E-value 6.5e-28 282459007539 Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase, score 197.4, E-value 2.3e-56 282459007540 Uncharacterized conserved protein [Function unknown]; Region: COG0327 282459007541 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 282459007542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 282459007543 Uncharacterized conserved protein [Function unknown]; Region: COG0327 282459007544 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 282459007545 Pfam match to entry PF01784 NIF3, NIF3 (NGG1p interacting factor 3), score 354.9, E-value 9.3e-104 282459007546 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 282459007547 Family of unknown function (DUF633); Region: DUF633; pfam04816 282459007548 Pfam match to entry PF04816 DUF633, Family of unknown function (DUF633), score 406.2, E-value 3.3e-119 282459007549 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 282459007550 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 282459007551 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 282459007552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 282459007553 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 282459007554 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 282459007555 DNA binding residues [nucleotide binding] 282459007556 Pfam match to entry PF04545 sigma70_r4, Sigma-70, region 4, score 92.9, E-value 6.7e-25 282459007557 PS00716 Sigma-70 factors family signature 2. 282459007558 Predicted helix-turn-helix motif for SAS1499 with score 1909.000, SD 5.69 at aa 327-348, sequence RTLEEVGKVFGVTRERIRQIEA 282459007559 Pfam match to entry PF04539 sigma70_r3, Sigma-70 region 3, score 152.4, E-value 8.3e-43 282459007560 Pfam match to entry PF04542 sigma70_r2, Sigma-70 region 2, score 105.9, E-value 8.3e-29 282459007561 PS00715 Sigma-70 factors family signature 1. 282459007562 Pfam match to entry PF00140 sigma70_r1_2, Sigma-70 factor, region 1.2, score 78.5, E-value 1.4e-20 282459007563 Pfam match to entry PF03979 sigma70_r1_1, Sigma-70 factor, region 1.1, score 102.9, E-value 6.6e-28 282459007564 DNA primase, catalytic core; Region: dnaG; TIGR01391 282459007565 CHC2 zinc finger; Region: zf-CHC2; pfam01807 282459007566 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 282459007567 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 282459007568 active site 282459007569 metal binding site [ion binding]; metal-binding site 282459007570 interdomain interaction site; other site 282459007571 Pfam match to entry PF01751 Toprim, Toprim domain, score 70.8, E-value 3.1e-18 282459007572 Pfam match to entry PF01807 zf-CHC2, CHC2 zinc finger, score 198.6, E-value 1e-56 282459007573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 282459007574 Pfam match to entry PF03618 DUF299, Domain of unknown function (DUF299), score 531.7, E-value 5.3e-157 282459007575 Similar to Bacillus halodurans hypothetical protein BH1372 SWALL:Q9KD47 (EMBL:AP001511) (214 aa) fasta scores: E(): 1.4e-44, 56.73% id in 208 aa, and to Staphylococcus aureus hypothetical protein SAV1564 or SA1393 SWALL:Q99TT2 (EMBL:AP003362) (207 aa) fasta scores: E(): 1.1e-74, 99.51% id in 207 aa. CDS lacks an inframe translational start site. Frameshift or point mutation could generate a start codon. Possible alternative rare translational start at codon 4; Ortholog of S. aureus MRSA252 (BX571856) SAR1641; DNA-binding protein (pseudogene) 282459007576 Pfam match to entry PF00571 CBS, CBS domain, score 29.2, E-value 9.9e-06 282459007577 Pfam match to entry PF00571 CBS, CBS domain, score 40.9, E-value 3.1e-09 282459007578 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007579 Predicted helix-turn-helix motif for SAS1502 with score 1511.000, SD 4.33 at aa 23-44, sequence ITGEQIADKLNLTRATLRPDLA 282459007580 glycyl-tRNA synthetase; Provisional; Region: PRK04173 282459007581 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 282459007582 motif 1; other site 282459007583 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 282459007584 active site 282459007585 motif 2; other site 282459007586 motif 3; other site 282459007587 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 282459007588 anticodon binding site; other site 282459007589 Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II core domain (G, H, P, S and T), score 210.1, E-value 3.4e-60 282459007590 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007591 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 282459007592 Pfam match to entry PF03129 HGTP_anticodon, Anticodon binding domain, score 120.6, E-value 3.1e-33 282459007593 DNA repair protein RecO; Region: reco; TIGR00613 282459007594 Recombination protein O N terminal; Region: RecO_N; pfam11967 282459007595 Recombination protein O C terminal; Region: RecO_C; pfam02565 282459007596 Pfam match to entry PF02565 RecO, Recombination protein O, score 13.5, E-value 9.1e-08 282459007597 GTPase Era; Reviewed; Region: era; PRK00089 282459007598 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 282459007599 G1 box; other site 282459007600 GTP/Mg2+ binding site [chemical binding]; other site 282459007601 Switch I region; other site 282459007602 G2 box; other site 282459007603 Switch II region; other site 282459007604 G3 box; other site 282459007605 G4 box; other site 282459007606 G5 box; other site 282459007607 KH domain; Region: KH_2; pfam07650 282459007608 Pfam match to entry PF00013 KH, KH domain, score 15.0, E-value 0.011 282459007609 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007610 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 282459007611 active site 282459007612 catalytic motif [active] 282459007613 Zn binding site [ion binding]; other site 282459007614 Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region, score 62.3, E-value 1.1e-15 282459007615 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 282459007616 Pfam match to entry PF01219 DAGK_prokar, Prokaryotic diacylglycerol kinase, score 111.3, E-value 2e-30 282459007617 3 probable transmembrane helices predicted for SAS1507 by TMHMM2.0 at aa 21-38, 43-65 and 86-108 282459007618 PS01069 Prokaryotic diacylglycerol kinase signature. 282459007619 metal-binding heat shock protein; Provisional; Region: PRK00016 282459007620 Pfam match to entry PF02130 UPF0054, Uncharacterized protein family UPF0054, score 170.6, E-value 2.8e-48 282459007621 PS01306 Uncharacterized protein family UPF0054 signature. 282459007622 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 282459007623 PhoH-like protein; Region: PhoH; pfam02562 282459007624 Pfam match to entry PF02562 PhoH, PhoH-like protein, score 545.2, E-value 4.6e-161 282459007625 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007626 Signal peptide predicted for SAS1511 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.618 between residues 34 and 35; signal peptide 282459007627 hypothetical protein; Provisional; Region: PRK13665 282459007628 2 probable transmembrane helices predicted for SAS1511 by TMHMM2.0 at aa 2-24 and 28-47 282459007629 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 282459007630 Pfam match to entry PF01957 NfeD, Nodulation efficiency protein D (NfeD), score 29.8, E-value 1.3e-08 282459007631 4 probable transmembrane helices predicted for SAS1512 by TMHMM2.0 at aa 28-50, 57-79, 84-117 and 124-146 282459007632 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 282459007633 Pfam match to entry PF01165 Ribosomal_S21, Ribosomal protein S21, score 112.9, E-value 6.3e-31 282459007634 PS01181 Ribosomal protein S21 signature. 282459007635 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 282459007636 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 282459007637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282459007638 FeS/SAM binding site; other site 282459007639 TRAM domain; Region: TRAM; cl01282 282459007640 Pfam match to entry PF01938 TRAM, TRAM domain, score 23.0, E-value 0.00075 282459007641 Pfam match to entry PF04055 Radical_SAM, Radical SAM superfamily, score 120.9, E-value 2.4e-33 282459007642 PS01278 Uncharacterized protein family UPF0004 signature. 282459007643 Pfam match to entry PF00919 UPF0004, Uncharacterized protein family UPF0004, score 149.9, E-value 4.6e-42 282459007644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 282459007645 RNA methyltransferase, RsmE family; Region: TIGR00046 282459007646 Pfam match to entry PF04452 DUF558, Protein of unknown function (DUF558), score 187.3, E-value 2.6e-53 282459007647 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 282459007648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459007649 S-adenosylmethionine binding site [chemical binding]; other site 282459007650 Pfam match to entry PF06325 PrmA, Ribosomal protein L11 methyltransferase (PrmA), score 536.2, E-value 2.5e-158 282459007651 chaperone protein DnaJ; Provisional; Region: PRK14280 282459007652 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 282459007653 HSP70 interaction site [polypeptide binding]; other site 282459007654 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 282459007655 substrate binding site [polypeptide binding]; other site 282459007656 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 282459007657 Zn binding sites [ion binding]; other site 282459007658 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 282459007659 dimer interface [polypeptide binding]; other site 282459007660 Pfam match to entry PF01556 DnaJ_C, DnaJ C terminal region, score 273.6, E-value 2.6e-79 282459007661 Pfam match to entry PF00684 DnaJ_CXXCXGXG, DnaJ central domain (4 repeats), score 155.5, E-value 9.8e-44 282459007662 PS00637 CXXCXGXG dnaJ domain signature. 282459007663 PS00190 Cytochrome c family heme-binding site signature. 282459007664 Pfam match to entry PF00226 DnaJ, DnaJ domain, score 146.6, E-value 4.6e-41 282459007665 PS00636 Nt-dnaJ domain signature. 282459007666 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 282459007667 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 282459007668 nucleotide binding site [chemical binding]; other site 282459007669 NEF interaction site [polypeptide binding]; other site 282459007670 SBD interface [polypeptide binding]; other site 282459007671 Pfam match to entry PF00012 HSP70, Hsp70 protein, score 1266.6, E-value 0 282459007672 PS01036 Heat shock hsp70 proteins family signature 3. 282459007673 PS00329 Heat shock hsp70 proteins family signature 2. 282459007674 PS00297 Heat shock hsp70 proteins family signature 1. 282459007675 heat shock protein GrpE; Provisional; Region: PRK14140 282459007676 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 282459007677 dimer interface [polypeptide binding]; other site 282459007678 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 282459007679 Pfam match to entry PF01025 GrpE, GrpE, score 289.9, E-value 3.3e-84 282459007680 PS01071 grpE protein signature. 282459007681 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 282459007682 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 282459007683 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 282459007684 Pfam match to entry PF01628 HrcA, HrcA protein C terminal domain, score 281.3, E-value 1.3e-81 282459007685 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 282459007686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282459007687 FeS/SAM binding site; other site 282459007688 HemN C-terminal domain; Region: HemN_C; pfam06969 282459007689 Pfam match to entry PF04055 Radical_SAM, Radical SAM superfamily, score 113.2, E-value 5.1e-31 282459007690 GTP-binding protein LepA; Provisional; Region: PRK05433 282459007691 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 282459007692 G1 box; other site 282459007693 putative GEF interaction site [polypeptide binding]; other site 282459007694 GTP/Mg2+ binding site [chemical binding]; other site 282459007695 Switch I region; other site 282459007696 G2 box; other site 282459007697 G3 box; other site 282459007698 Switch II region; other site 282459007699 G4 box; other site 282459007700 G5 box; other site 282459007701 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 282459007702 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 282459007703 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 282459007704 Pfam match to entry PF00679 EFG_C, Elongation factor G C-terminus, score 148.3, E-value 1.4e-41 282459007705 Pfam match to entry PF03144 GTP_EFTU_D2, Elongation factor Tu domain 2, score 54.7, E-value 2.2e-13 282459007706 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu GTP binding domain, score 231.3, E-value 1.5e-66 282459007707 PS00301 GTP-binding elongation factors signature. 282459007708 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007709 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 282459007710 Pfam match to entry PF01649 Ribosomal_S20p, Ribosomal protein S20, score 60.1, E-value 5.1e-15 282459007711 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 282459007712 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 282459007713 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 282459007714 Competence protein; Region: Competence; pfam03772 282459007715 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 282459007716 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 282459007717 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 51.5, E-value 1.9e-12 282459007718 10 probable transmembrane helices predicted for SAS1525 by TMHMM2.0 at aa 10-31, 38-57, 203-222, 229-248, 253-270, 282-316, 326-348, 361-383, 423-440 and 445-462 282459007719 Pfam match to entry PF03772 Competence, Competence protein, score 269.4, E-value 5e-78 282459007720 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 282459007721 catalytic motif [active] 282459007722 Zn binding site [ion binding]; other site 282459007723 Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region, score 151.6, E-value 1.4e-42 282459007724 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 282459007725 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 282459007726 SLBB domain; Region: SLBB; pfam10531 282459007727 Helix-hairpin-helix motif; Region: HHH; pfam00633 282459007728 Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif, score 12.0, E-value 0.22 282459007729 Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif, score 33.1, E-value 6.5e-07 282459007730 1 probable transmembrane helix predicted for SAS1527 by TMHMM2.0 at aa 15-35 282459007731 Methyltransferase domain; Region: Methyltransf_31; pfam13847 282459007732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459007733 S-adenosylmethionine binding site [chemical binding]; other site 282459007734 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 282459007735 Pfam match to entry PF02410 DUF143, Domain of unknown function DUF143, score 135.6, E-value 9.1e-38 282459007736 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 282459007737 Zn2+ binding site [ion binding]; other site 282459007738 Mg2+ binding site [ion binding]; other site 282459007739 Pfam match to entry PF01966 HD, HD domain, score 51.4, E-value 2.1e-12 282459007740 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 282459007741 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 282459007742 active site 282459007743 (T/H)XGH motif; other site 282459007744 Pfam match to entry PF01467 CTP_transf_2, Cytidylyltransferase, score 171.8, E-value 1.2e-48 282459007745 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 282459007746 Pfam match to entry PF01985 CRS1_YhbY, CRS1 / YhbY domain, score 169.4, E-value 6.1e-48 282459007747 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 282459007748 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 282459007749 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 282459007750 shikimate binding site; other site 282459007751 NAD(P) binding site [chemical binding]; other site 282459007752 Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase, score 268.2, E-value 1.1e-77 282459007753 GTPase YqeH; Provisional; Region: PRK13796 282459007754 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 282459007755 GTP/Mg2+ binding site [chemical binding]; other site 282459007756 G4 box; other site 282459007757 G5 box; other site 282459007758 G1 box; other site 282459007759 Switch I region; other site 282459007760 G2 box; other site 282459007761 G3 box; other site 282459007762 Switch II region; other site 282459007763 Pfam match to entry PF01926 MMR_HSR1, GTPase of unknown function, score 97.1, E-value 3.7e-26 282459007764 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007765 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 282459007766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459007767 active site 282459007768 motif I; other site 282459007769 motif II; other site 282459007770 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 23.4, E-value 1.9e-06 282459007771 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 282459007772 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 282459007773 Pfam match to entry PF01048 PNP_UDP_1, Phosphorylase family, score 299.5, E-value 4.3e-87 282459007774 3 probable transmembrane helices predicted for SAS1537 by TMHMM2.0 at aa 13-32, 42-64 and 71-88 282459007775 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 282459007776 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459007777 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 103.9, E-value 3.3e-28 282459007778 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459007779 PS00277 Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin signature 1. 282459007780 Pfam match to entry PF01123 Stap_Strp_toxin, Staphylococcal/Streptococcal toxin, OB-fold domain, score 78.7, E-value 1.3e-20 282459007781 Fic family protein [Function unknown]; Region: COG3177 282459007782 Fic/DOC family; Region: Fic; pfam02661 282459007783 Predicted helix-turn-helix motif for SAS1539 with score 983.000, SD 2.53 at aa 357-378, sequence LTLIDLENILGVGRVKINNTIK 282459007784 Pfam match to entry PF02661 Fic, Fic protein family, score 132.0, E-value 1.1e-36 282459007785 Signal peptide predicted for SAS1540 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.867 between residues 57 and 58; signal peptide 282459007786 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 282459007787 11 probable transmembrane helices predicted for SAS1540 by TMHMM2.0 at aa 21-40, 55-77, 90-109, 124-146, 153-175, 195-217, 238-260, 288-310, 323-340, 345-367 and 380-402 282459007788 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 282459007789 putative active site [active] 282459007790 Pfam match to entry PF03746 LamB_YcsF, LamB/YcsF family, score 586.3, E-value 2e-173 282459007791 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 282459007792 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 282459007793 ATP-grasp domain; Region: ATP-grasp_4; cl17255 282459007794 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 282459007795 Pfam match to entry PF02785 Biotin_carb_C, Biotin carboxylase C-terminal domain, score 160.8, E-value 2.5e-45 282459007796 Pfam match to entry PF02786 CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain, score 264.6, E-value 1.4e-76 282459007797 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 282459007798 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 282459007799 Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase L chain, N-terminal domain, score 151.4, E-value 1.7e-42 282459007800 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 282459007801 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 282459007802 carboxyltransferase (CT) interaction site; other site 282459007803 biotinylation site [posttranslational modification]; other site 282459007804 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme, score 72.7, E-value 8e-19 282459007805 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 282459007806 Pfam match to entry PF02626 AHS2, Allophanate hydrolase subunit 2, score 237.9, E-value 1.5e-68 282459007807 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 282459007808 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 282459007809 Pfam match to entry PF02682 AHS1, Allophanate hydrolase subunit 1, score 234.4, E-value 1.7e-67 282459007810 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 282459007811 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 282459007812 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 282459007813 Pfam match to entry PF01272 GreA_GreB, Prokaryotic transcription elongation factor, GreA/GreB, C-terminal domain, score 75.2, E-value 1.4e-19 282459007814 PS00830 Prokaryotic transcription elongation factors signature 2. 282459007815 Pfam match to entry PF03449 GreA_GreB_N, Prokaryotic transcription elongation factor, GreA/GreB, N-terminal domain, score 119.0, E-value 9.2e-33 282459007816 PS00829 Prokaryotic transcription elongation factors signature 1. 282459007817 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 282459007818 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 282459007819 Sugar specificity; other site 282459007820 Pyrimidine base specificity; other site 282459007821 ATP-binding site [chemical binding]; other site 282459007822 Pfam match to entry PF00485 PRK, Phosphoribulokinase / Uridine kinase family, score 181.8, E-value 1.1e-51 282459007823 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007824 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 282459007825 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 282459007826 Peptidase family U32; Region: Peptidase_U32; pfam01136 282459007827 Pfam match to entry PF01136 Peptidase_U32, Peptidase family U32, score 442.5, E-value 3.9e-130 282459007828 PS01276 Peptidase family U32 signature. 282459007829 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 282459007830 Peptidase family U32; Region: Peptidase_U32; pfam01136 282459007831 Pfam match to entry PF01136 Peptidase_U32, Peptidase family U32, score 247.1, E-value 2.5e-71 282459007832 PS00018 EF-hand calcium-binding domain. 282459007833 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 282459007834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459007835 S-adenosylmethionine binding site [chemical binding]; other site 282459007836 Pfam match to entry PF01596 Methyltransf_3, O-methyltransferase, score -28.9, E-value 2.6e-10 282459007837 hypothetical protein; Provisional; Region: PRK13678 282459007838 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 282459007839 Pfam match to entry PF03652 UPF0081, Uncharacterised protein family (UPF0081), score 168.3, E-value 1.3e-47 282459007840 hypothetical protein; Provisional; Region: PRK05473 282459007841 Pfam match to entry PF06135 DUF965, Bacterial protein of unknown function (DUF965), score 171.7, E-value 1.3e-48 282459007842 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 282459007843 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 282459007844 motif 1; other site 282459007845 active site 282459007846 motif 2; other site 282459007847 motif 3; other site 282459007848 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 282459007849 DHHA1 domain; Region: DHHA1; pfam02272 282459007850 Pfam match to entry PF02272 DHHA1, DHHA1 domain, score 79.6, E-value 6.7e-21 282459007851 Pfam match to entry PF01411 tRNA-synt_2c, tRNA synthetases class II (A), score 1353.1, E-value 0 282459007852 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282459007853 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 282459007854 AAA domain; Region: AAA_30; pfam13604 282459007855 Family description; Region: UvrD_C_2; pfam13538 282459007856 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 282459007858 binding surface 282459007859 TPR motif; other site 282459007860 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 282459007861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 282459007862 binding surface 282459007863 TPR motif; other site 282459007864 TPR repeat; Region: TPR_11; pfam13414 282459007865 Pfam match to entry PF00515 TPR, TPR Domain, score 28.2, E-value 2e-05 282459007866 Pfam match to entry PF00515 TPR, TPR Domain, score 13.5, E-value 0.093 282459007867 Pfam match to entry PF00515 TPR, TPR Domain, score 13.6, E-value 0.089 282459007868 Pfam match to entry PF00515 TPR, TPR Domain, score 32.9, E-value 7.8e-07 282459007869 Pfam match to entry PF00515 TPR, TPR Domain, score 26.1, E-value 8.6e-05 282459007870 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 282459007871 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 282459007872 Pfam match to entry PF03054 tRNA_Me_trans, tRNA methyl transferase, score 723.2, E-value 1.2e-214 282459007873 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 282459007874 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 282459007875 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282459007876 catalytic residue [active] 282459007877 Pfam match to entry PF00266 aminotran_5, Aminotransferase class-V, score 340.1, E-value 2.6e-99 282459007878 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 282459007879 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 282459007880 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 282459007881 Pfam match to entry PF00296 bac_luciferase, Luciferase-like monooxygenase, score 185.7, E-value 7.6e-53 282459007882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 282459007883 Pfam match to entry PF05532 CsbD, CsbD-like, score 87.1, E-value 3.6e-23 282459007884 Predicted transcriptional regulator [Transcription]; Region: COG1959 282459007885 Transcriptional regulator; Region: Rrf2; pfam02082 282459007886 Pfam match to entry PF02082 Rrf2, Transcriptional regulator, score 139.3, E-value 7.2e-39 282459007887 PS01332 Uncharacterized protein family UPF0074 signature. 282459007888 recombination factor protein RarA; Reviewed; Region: PRK13342 282459007889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459007890 Walker A motif; other site 282459007891 ATP binding site [chemical binding]; other site 282459007892 Walker B motif; other site 282459007893 arginine finger; other site 282459007894 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 282459007895 Pfam match to entry PF00004 AAA, ATPase family associated with various cellular activities (AAA), score 61.3, E-value 2.2e-15 282459007896 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007897 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 282459007898 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 282459007899 putative ATP binding site [chemical binding]; other site 282459007900 putative substrate interface [chemical binding]; other site 282459007901 Pfam match to entry PF00899 ThiF, ThiF family, score 114.1, E-value 2.8e-31 282459007902 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 282459007903 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 282459007904 dimer interface [polypeptide binding]; other site 282459007905 anticodon binding site; other site 282459007906 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 282459007907 homodimer interface [polypeptide binding]; other site 282459007908 motif 1; other site 282459007909 active site 282459007910 motif 2; other site 282459007911 GAD domain; Region: GAD; pfam02938 282459007912 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 282459007913 motif 3; other site 282459007914 Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N), score 85.7, E-value 9.8e-23 282459007915 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282459007916 Pfam match to entry PF02938 GAD, GAD domain, score 124.3, E-value 2.3e-34 282459007917 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 282459007918 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain, score 87.3, E-value 3.2e-23 282459007919 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 282459007920 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 282459007921 dimer interface [polypeptide binding]; other site 282459007922 motif 1; other site 282459007923 active site 282459007924 motif 2; other site 282459007925 motif 3; other site 282459007926 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 282459007927 anticodon binding site; other site 282459007928 Pfam match to entry PF03129 HGTP_anticodon, Anticodon binding domain, score 88.9, E-value 1e-23 282459007929 Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II core domain (G, H, P, S and T), score 179.6, E-value 5.3e-51 282459007930 Signal peptide predicted for SAS1568 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.541 between residues 40 and 41; signal peptide 282459007931 Bacterial SH3 domain homologues; Region: SH3b; smart00287 282459007932 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 282459007933 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 282459007934 active site 282459007935 metal binding site [ion binding]; metal-binding site 282459007936 Pfam match to entry PF01520 Amidase_3, N-acetylmuramoyl-L-alanine amidase, score 156.9, E-value 3.6e-44 282459007937 1 probable transmembrane helix predicted for SAS1568 by TMHMM2.0 at aa 19-36 282459007938 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 282459007939 putative active site [active] 282459007940 dimerization interface [polypeptide binding]; other site 282459007941 putative tRNAtyr binding site [nucleotide binding]; other site 282459007942 Pfam match to entry PF02580 Tyr_Deacylase, D-Tyr-tRNA(Tyr) deacylase, score 258.4, E-value 1e-74 282459007943 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 282459007944 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 282459007945 Zn2+ binding site [ion binding]; other site 282459007946 Mg2+ binding site [ion binding]; other site 282459007947 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 282459007948 synthetase active site [active] 282459007949 NTP binding site [chemical binding]; other site 282459007950 metal binding site [ion binding]; metal-binding site 282459007951 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 282459007952 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 282459007953 Pfam match to entry PF01842 ACT, ACT domain, score 38.9, E-value 1.2e-08 282459007954 Pfam match to entry PF02824 TGS, TGS domain, score 103.1, E-value 5.8e-28 282459007955 Pfam match to entry PF04607 RelA_SpoT, Region found in RelA / SpoT proteins, score 269.0, E-value 6.5e-78 282459007956 Pfam match to entry PF01966 HD, HD domain, score 69.3, E-value 8.8e-18 282459007957 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282459007958 active site 282459007959 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 172.7, E-value 6.6e-49 282459007960 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 282459007961 DHH family; Region: DHH; pfam01368 282459007962 DHHA1 domain; Region: DHHA1; pfam02272 282459007963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 282459007964 Pfam match to entry PF02272 DHHA1, DHHA1 domain, score 44.8, E-value 2.1e-10 282459007965 Pfam match to entry PF01368 DHH, DHH family, score 148.5, E-value 1.2e-41 282459007966 Signal peptide predicted for SAS1573 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.416 between residues 22 and 23; signal peptide 282459007967 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 282459007968 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 282459007969 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 282459007970 Protein export membrane protein; Region: SecD_SecF; pfam02355 282459007971 Pfam match to entry PF02355 SecD_SecF, Protein export membrane protein, score 336.6, E-value 2.9e-98 282459007972 12 probable transmembrane helices predicted for SAS1573 by TMHMM2.0 at aa 7-29, 262-281, 288-310, 314-336, 356-378, 388-410, 456-478, 574-591, 598-620, 625-647, 681-703 and 707-729 282459007973 Preprotein translocase subunit; Region: YajC; pfam02699 282459007974 Pfam match to entry PF02699 YajC, Preprotein translocase subunit, score 97.2, E-value 3.5e-26 282459007975 1 probable transmembrane helix predicted for SAS1574 by TMHMM2.0 at aa 4-21 282459007976 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 282459007977 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 282459007978 Pfam match to entry PF01702 TGT, Queuine tRNA-ribosyltransferase, score 546.1, E-value 2.6e-161 282459007979 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 282459007980 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 282459007981 Pfam match to entry PF02547 Queuosine_synth, Queuosine biosynthesis protein, score 387.8, E-value 1.1e-113 282459007982 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 282459007983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459007984 Walker A motif; other site 282459007985 ATP binding site [chemical binding]; other site 282459007986 Walker B motif; other site 282459007987 arginine finger; other site 282459007988 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 282459007989 Pfam match to entry PF05491 RuvB_C, Holliday junction DNA helicase ruvB C-terminus, score 188.8, E-value 8.9e-54 282459007990 Pfam match to entry PF00004 AAA, ATPase family associated with various cellular activities (AAA), score 113.6, E-value 4.1e-31 282459007991 PS00017 ATP/GTP-binding site motif A (P-loop). 282459007992 Pfam match to entry PF05496 RuvB_N, Holliday junction DNA helicase ruvB N-terminus, score 100.9, E-value 2.5e-27 282459007993 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 282459007994 RuvA N terminal domain; Region: RuvA_N; pfam01330 282459007995 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 282459007996 Pfam match to entry PF01330 RuvA, RuvA N terminal domain, score 110.7, E-value 3e-30 282459007997 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 282459007998 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 282459007999 Pfam match to entry PF01842 ACT, ACT domain, score 29.5, E-value 8e-06 282459008000 Predicted helix-turn-helix motif for SAS1579 with score 1182.000, SD 3.21 at aa 38-59, sequence LSIYDAVKQFDLSRSAFYKYRE 282459008001 GTPase CgtA; Reviewed; Region: obgE; PRK12297 282459008002 GTP1/OBG; Region: GTP1_OBG; pfam01018 282459008003 Obg GTPase; Region: Obg; cd01898 282459008004 G1 box; other site 282459008005 GTP/Mg2+ binding site [chemical binding]; other site 282459008006 Switch I region; other site 282459008007 G2 box; other site 282459008008 G3 box; other site 282459008009 Switch II region; other site 282459008010 G4 box; other site 282459008011 G5 box; other site 282459008012 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 282459008013 Pfam match to entry PF01018 GTP1_OBG, GTP1/OBG family, score 410.3, E-value 1.9e-120 282459008014 PS00905 GTP1/OBG family signature. 282459008015 PS00017 ATP/GTP-binding site motif A (P-loop). 282459008016 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 282459008017 Pfam match to entry PF01016 Ribosomal_L27, Ribosomal L27 protein, score 185.7, E-value 7.7e-53 282459008018 PS00831 Ribosomal protein L27 signature. 282459008019 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 282459008020 Pfam match to entry PF04327 DUF464, Protein of unknown function (DUF464), score 186.7, E-value 3.9e-53 282459008021 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 282459008022 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 282459008023 Pfam match to entry PF00829 Ribosomal_L21p, Ribosomal prokaryotic L21 protein, score 174.1, E-value 2.4e-49 282459008024 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 282459008025 Pfam match to entry PF04093 MreD, rod shape-determining protein MreD, score 216.6, E-value 3.8e-62 282459008026 5 probable transmembrane helices predicted for SAS1584 by TMHMM2.0 at aa 5-27, 42-64, 71-93, 103-125 and 137-159 282459008027 Signal peptide predicted for SAS1585 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.904 between residues 32 and 33; signal peptide 282459008028 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 282459008029 rod shape-determining protein MreC; Region: MreC; pfam04085 282459008030 Pfam match to entry PF04085 MreC, rod shape-determining protein MreC, score 251.6, E-value 1.1e-72 282459008031 1 probable transmembrane helix predicted for SAS1585 by TMHMM2.0 at aa 10-28 282459008032 1 probable transmembrane helix predicted for SAS1586 by TMHMM2.0 at aa 3-25 282459008033 Signal peptide predicted for SAS1587 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.758 between residues 24 and 25; signal peptide 282459008034 2 probable transmembrane helices predicted for SAS1587 by TMHMM2.0 at aa 5-27 and 32-54 282459008035 3 probable transmembrane helices predicted for SAS1588 by TMHMM2.0 at aa 4-21, 30-52 and 62-84 282459008036 hypothetical protein; Reviewed; Region: PRK00024 282459008037 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 282459008038 MPN+ (JAMM) motif; other site 282459008039 Zinc-binding site [ion binding]; other site 282459008040 Pfam match to entry PF04002 RadC, RadC, DNA repair protein, score 191.8, E-value 1.2e-54 282459008041 PS01302 DNA repair protein radC family signature. 282459008042 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 282459008043 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 282459008044 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 282459008045 Pfam match to entry PF01478 Peptidase_A24, Type IV leader peptidase family, score -62.5, E-value 1.1e-07 282459008046 6 probable transmembrane helices predicted for SAS1590 by TMHMM2.0 at aa 68-86, 90-109, 122-144, 154-176, 178-200 and 205-223 282459008047 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 282459008048 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 282459008049 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 282459008050 Pfam match to entry PF02875 Mur_ligase_C, Mur ligase family, glutamate ligase domain, score 18.2, E-value 0.0021 282459008051 Pfam match to entry PF01225 Mur_ligase, Mur ligase family, catalytic domain, score 80.1, E-value 4.7e-21 282459008052 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 282459008053 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 282459008054 active site 282459008055 HIGH motif; other site 282459008056 nucleotide binding site [chemical binding]; other site 282459008057 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 282459008058 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 282459008059 active site 282459008060 KMSKS motif; other site 282459008061 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 282459008062 tRNA binding surface [nucleotide binding]; other site 282459008063 anticodon binding site; other site 282459008064 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 282459008065 Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V), score 954.0, E-value 4e-284 282459008066 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282459008067 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 282459008068 Pfam match to entry PF03352 Adenine_glyco, Methyladenine glycosylase, score 427.0, E-value 1.7e-125 282459008069 Signal peptide predicted for SAS1594 by SignalP 2.0 HMM (Signal peptide probabilty 0.805) with cleavage site probability 0.392 between residues 39 and 40; signal peptide 282459008070 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 282459008071 Putative ammonia monooxygenase; Region: AmoA; pfam05145 282459008072 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 282459008073 Pfam match to entry PF05145 AmoA, ammonia monooxygenase, score 562.7, E-value 2.5e-166 282459008074 8 probable transmembrane helices predicted for SAS1594 by TMHMM2.0 at aa 7-29, 83-105, 140-162, 182-204, 213-235, 269-291, 298-320 and 330-348 282459008075 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 282459008076 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 282459008077 inhibitor-cofactor binding pocket; inhibition site 282459008078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459008079 catalytic residue [active] 282459008080 Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III, score 423.5, E-value 2e-124 282459008081 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 282459008082 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 282459008083 dimer interface [polypeptide binding]; other site 282459008084 active site 282459008085 Schiff base residues; other site 282459008086 Pfam match to entry PF00490 ALAD, Delta-aminolevulinic acid dehydratase, score 658.2, E-value 4.6e-195 282459008087 PS00169 Delta-aminolevulinic acid dehydratase active site. 282459008088 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 282459008089 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 282459008090 active site 282459008091 Pfam match to entry PF02602 HEM4, Uroporphyrinogen-III synthase HemD, score 103.2, E-value 5.4e-28 282459008092 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 282459008093 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 282459008094 domain interfaces; other site 282459008095 active site 282459008096 Pfam match to entry PF03900 Porphobil_deamC, Porphobilinogen deaminase, C-terminal domain, score 125.2, E-value 1.2e-34 282459008097 PS00533 Porphobilinogen deaminase cofactor-binding site. 282459008098 Pfam match to entry PF01379 Porphobil_deam, Porphobilinogen deaminase, dipyromethane cofactor binding domain, score 479.8, E-value 2.3e-141 282459008099 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 282459008100 8 probable transmembrane helices predicted for SAS1600 by TMHMM2.0 at aa 4-26, 38-60, 65-87, 92-114, 134-156, 184-206, 221-240 and 247-269 282459008101 Pfam match to entry PF01578 CytC_asm, Cytochrome C assembly protein, score 26.8, E-value 1.5e-05 282459008102 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 282459008103 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 282459008104 tRNA; other site 282459008105 putative tRNA binding site [nucleotide binding]; other site 282459008106 putative NADP binding site [chemical binding]; other site 282459008107 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 282459008108 Pfam match to entry PF00745 GlutR_dimer, Glutamyl-tRNAGlu reductase, dimerisation domain, score 111.9, E-value 1.3e-30 282459008109 Pfam match to entry PF05200 GlutR_NAD_bind, Glutamyl-tRNAGlu reductase, NAD(P) binding domain, score 266.3, E-value 4.2e-77 282459008110 Pfam match to entry PF05201 GlutR_N, Glutamyl-tRNAGlu reductase, N-terminal domain, score 274.6, E-value 1.4e-79 282459008111 PS00747 Glutamyl-tRNA reductase signature. 282459008112 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 282459008113 G1 box; other site 282459008114 GTP/Mg2+ binding site [chemical binding]; other site 282459008115 Switch I region; other site 282459008116 G2 box; other site 282459008117 G3 box; other site 282459008118 Switch II region; other site 282459008119 G4 box; other site 282459008120 G5 box; other site 282459008121 PS00017 ATP/GTP-binding site motif A (P-loop). 282459008122 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 282459008123 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 282459008124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459008125 Walker A motif; other site 282459008126 ATP binding site [chemical binding]; other site 282459008127 Walker B motif; other site 282459008128 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 282459008129 Pfam match to entry PF00004 AAA, ATPase family associated with various cellular activities (AAA), score 86.5, E-value 5.5e-23 282459008130 PS00017 ATP/GTP-binding site motif A (P-loop). 282459008131 trigger factor; Provisional; Region: tig; PRK01490 282459008132 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 282459008133 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 282459008134 Pfam match to entry PF05698 Trigger_C, Bacterial trigger factor protein (TF) C-terminus, score 226.1, E-value 5.5e-65 282459008135 Pfam match to entry PF00254 FKBP, FKBP-type peptidyl-prolyl cis-trans isomerase, score 94.7, E-value 1.9e-25 282459008136 Pfam match to entry PF05697 Trigger_N, Bacterial trigger factor protein (TF), score 252.1, E-value 8e-73 282459008137 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 282459008138 Pfam match to entry PF00293 NUDIX, NUDIX domain, score 8.2, E-value 0.041 282459008139 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 282459008140 23S rRNA binding site [nucleotide binding]; other site 282459008141 L21 binding site [polypeptide binding]; other site 282459008142 L13 binding site [polypeptide binding]; other site 282459008143 Pfam match to entry PF00453 Ribosomal_L20, Ribosomal protein L20, score 238.8, E-value 8.2e-69 282459008144 PS00937 Ribosomal protein L20 signature. 282459008145 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 282459008146 Pfam match to entry PF01632 Ribosomal_L35p, Ribosomal protein L35, score 107.4, E-value 3e-29 282459008147 PS00936 Ribosomal protein L35 signature. 282459008148 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 282459008149 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 282459008150 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 282459008151 Pfam match to entry PF00707 IF3_C, Translation initiation factor IF-3, C-terminal domain, score 176.4, E-value 4.8e-50 282459008152 Pfam match to entry PF05198 IF3_N, Translation initiation factor IF-3, N-terminal domain, score 179.1, E-value 7.7e-51 282459008153 PS00938 Initiation factor 3 signature. 282459008154 Signal peptide predicted for SAS1610 by SignalP 2.0 HMM (Signal peptide probabilty 0.899) with cleavage site probability 0.744 between residues 41 and 42; signal peptide 282459008155 lysine transporter; Provisional; Region: PRK10836 282459008156 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score 551.7, E-value 5.2e-163 282459008157 12 probable transmembrane helices predicted for SAS1610 by TMHMM2.0 at aa 21-43, 47-69, 101-123, 128-150, 162-184, 199-221, 250-269, 295-317, 347-366, 376-398, 419-438 and 453-470 282459008158 PS00017 ATP/GTP-binding site motif A (P-loop). 282459008159 PS00218 Amino acid permeases signature. 282459008160 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 282459008161 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 282459008162 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 282459008163 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 282459008164 active site 282459008165 dimer interface [polypeptide binding]; other site 282459008166 motif 1; other site 282459008167 motif 2; other site 282459008168 motif 3; other site 282459008169 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 282459008170 anticodon binding site; other site 282459008171 Pfam match to entry PF03129 HGTP_anticodon, Anticodon binding domain, score 130.6, E-value 3e-36 282459008172 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282459008173 Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II core domain (G, H, P, S and T), score 183.8, E-value 3e-52 282459008174 Pfam match to entry PF02824 TGS, TGS domain, score 65.8, E-value 9.4e-17 282459008175 primosomal protein DnaI; Reviewed; Region: PRK08939 282459008176 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 282459008177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459008178 Walker A motif; other site 282459008179 ATP binding site [chemical binding]; other site 282459008180 Walker B motif; other site 282459008181 PS00017 ATP/GTP-binding site motif A (P-loop). 282459008182 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 282459008183 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 282459008184 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 282459008185 ATP cone domain; Region: ATP-cone; pfam03477 282459008186 Pfam match to entry PF03477 ATP-cone, ATP cone domain, score 127.8, E-value 2.2e-35 282459008187 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 282459008188 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 282459008189 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 282459008190 Pfam match to entry PF02800 gpdh_C, Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, score 332.8, E-value 4.2e-97 282459008191 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 282459008192 Pfam match to entry PF00044 gpdh, Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain, score 226.5, E-value 4e-65 282459008193 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 282459008194 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 282459008195 CoA-binding site [chemical binding]; other site 282459008196 ATP-binding [chemical binding]; other site 282459008197 Pfam match to entry PF01121 CoaE, Dephospho-CoA kinase, score 242.4, E-value 6.7e-70 282459008198 PS00017 ATP/GTP-binding site motif A (P-loop). 282459008199 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 282459008200 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 282459008201 DNA binding site [nucleotide binding] 282459008202 catalytic residue [active] 282459008203 H2TH interface [polypeptide binding]; other site 282459008204 putative catalytic residues [active] 282459008205 turnover-facilitating residue; other site 282459008206 intercalation triad [nucleotide binding]; other site 282459008207 8OG recognition residue [nucleotide binding]; other site 282459008208 putative reading head residues; other site 282459008209 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 282459008210 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 282459008211 Pfam match to entry PF01149 Fapy_DNA_glyco, Formamidopyrimidine-DNA glycosylase, score 263.2, E-value 3.7e-76 282459008212 DNA polymerase I; Provisional; Region: PRK05755 282459008213 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 282459008214 active site 282459008215 metal binding site 1 [ion binding]; metal-binding site 282459008216 putative 5' ssDNA interaction site; other site 282459008217 metal binding site 3; metal-binding site 282459008218 metal binding site 2 [ion binding]; metal-binding site 282459008219 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 282459008220 putative DNA binding site [nucleotide binding]; other site 282459008221 putative metal binding site [ion binding]; other site 282459008222 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 282459008223 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 282459008224 active site 282459008225 DNA binding site [nucleotide binding] 282459008226 catalytic site [active] 282459008227 Pfam match to entry PF00476 DNA_pol_A, DNA polymerase family A, score 650.5, E-value 9.6e-193 282459008228 PS00447 DNA polymerase family A signature. 282459008229 Pfam match to entry PF01612 3_5_exonuclease, 3'-5' exonuclease, score -32.1, E-value 0.0029 282459008230 Pfam match to entry PF01367 5_3_exonuclease, 5'-3' exonuclease, C-terminal SAM fold, score 172.4, E-value 7.9e-49 282459008231 Pfam match to entry PF02739 5_3_exonuc_N, 5'-3' exonuclease, N-terminal resolvase-like domain, score 311.5, E-value 1.1e-90 282459008232 13 probable transmembrane helices predicted for SAS1619 by TMHMM2.0 at aa 9-31, 63-85, 98-116, 126-148, 153-170, 174-191, 198-215, 254-276, 289-311, 321-343, 350-372, 377-392 and 404-426 282459008233 Signal peptide predicted for SAS1620 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.987 between residues 29 and 30; signal peptide 282459008234 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 282459008235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282459008236 dimer interface [polypeptide binding]; other site 282459008237 phosphorylation site [posttranslational modification] 282459008238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459008239 ATP binding site [chemical binding]; other site 282459008240 Mg2+ binding site [ion binding]; other site 282459008241 G-X-G motif; other site 282459008242 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 152.9, E-value 5.6e-43 282459008243 Pfam match to entry PF00512 HisKA, His Kinase A (phosphoacceptor) domain, score 84.8, E-value 1.9e-22 282459008244 Pfam match to entry PF00989 PAS, PAS domain, score 24.4, E-value 2.4e-06 282459008245 Pfam match to entry PF00672 HAMP, HAMP domain, score 30.8, E-value 3.3e-06 282459008246 2 probable transmembrane helices predicted for SAS1620 by TMHMM2.0 at aa 10-32 and 128-150 282459008247 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282459008248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459008249 active site 282459008250 phosphorylation site [posttranslational modification] 282459008251 intermolecular recognition site; other site 282459008252 dimerization interface [polypeptide binding]; other site 282459008253 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282459008254 DNA binding site [nucleotide binding] 282459008255 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 104.9, E-value 1.6e-28 282459008256 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 156.2, E-value 5.8e-44 282459008257 isocitrate dehydrogenase; Reviewed; Region: PRK07006 282459008258 isocitrate dehydrogenase; Validated; Region: PRK07362 282459008259 Pfam match to entry PF00180 isodh, Isocitrate/isopropylmalate dehydrogenase, score 564.9, E-value 5.4e-167 282459008260 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 282459008261 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 282459008262 dimer interface [polypeptide binding]; other site 282459008263 Citrate synthase; Region: Citrate_synt; pfam00285 282459008264 active site 282459008265 citrylCoA binding site [chemical binding]; other site 282459008266 oxalacetate/citrate binding site [chemical binding]; other site 282459008267 coenzyme A binding site [chemical binding]; other site 282459008268 catalytic triad [active] 282459008269 Pfam match to entry PF00285 citrate_synt, Citrate synthase, score 526.6, E-value 1.8e-155 282459008270 PS00480 Citrate synthase signature. 282459008271 Signal peptide predicted for SAS1624 by SignalP 2.0 HMM (Signal peptide probabilty 0.674) with cleavage site probability 0.406 between residues 36 and 37; signal peptide 282459008272 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 282459008273 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score 407.2, E-value 1.7e-119 282459008274 12 probable transmembrane helices predicted for SAS1624 by TMHMM2.0 at aa 13-35, 39-61, 80-102, 122-144, 151-173, 198-220, 233-255, 270-292, 327-349, 359-381, 402-421 and 426-444 282459008275 pyruvate kinase; Provisional; Region: PRK06354 282459008276 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 282459008277 domain interfaces; other site 282459008278 active site 282459008279 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 282459008280 Pfam match to entry PF00391 PEP-utilizers, PEP-utilising enzyme, mobile domain, score 46.7, E-value 5.5e-11 282459008281 Pfam match to entry PF02887 PK_C, Pyruvate kinase, alpha/beta domain, score 157.8, E-value 1.9e-44 282459008282 Pfam match to entry PF00224 PK, Pyruvate kinase, barrel domain, score 744.5, E-value 4.8e-221 282459008283 6-phosphofructokinase; Provisional; Region: PRK03202 282459008284 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 282459008285 active site 282459008286 ADP/pyrophosphate binding site [chemical binding]; other site 282459008287 dimerization interface [polypeptide binding]; other site 282459008288 allosteric effector site; other site 282459008289 fructose-1,6-bisphosphate binding site; other site 282459008290 Pfam match to entry PF00365 PFK, Phosphofructokinase, score 558.7, E-value 4e-165 282459008291 PS00433 Phosphofructokinase signature. 282459008292 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 282459008293 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 282459008294 Pfam match to entry PF03255 ACCA, Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit, score 300.2, E-value 2.6e-87 282459008295 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 282459008296 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 282459008297 Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain, score 42.0, E-value 1.2e-11 282459008298 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 282459008299 Malic enzyme, N-terminal domain; Region: malic; pfam00390 282459008300 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 282459008301 putative NAD(P) binding site [chemical binding]; other site 282459008302 Pfam match to entry PF03949 malic_N, Malic enzyme, NAD binding domain, score 405.7, E-value 4.6e-119 282459008303 PS00331 Malic enzymes signature. 282459008304 Pfam match to entry PF00390 malic, Malic enzyme, N-terminal domain, score 273.1, E-value 3.8e-79 282459008305 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 282459008306 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 282459008307 active site 282459008308 PHP Thumb interface [polypeptide binding]; other site 282459008309 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 282459008310 generic binding surface I; other site 282459008311 generic binding surface II; other site 282459008312 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain, score 20.9, E-value 0.0031 282459008313 PS00017 ATP/GTP-binding site motif A (P-loop). 282459008314 Pfam match to entry PF02231 PHP_N, PHP domain N-terminal region, score 62.3, E-value 1.1e-15 282459008315 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 282459008316 DHH family; Region: DHH; pfam01368 282459008317 DHHA1 domain; Region: DHHA1; pfam02272 282459008318 Pfam match to entry PF02272 DHHA1, DHHA1 domain, score 49.2, E-value 9.5e-12 282459008319 PS00126 3'5'-cyclic nucleotide phosphodiesterases signature. 282459008320 Pfam match to entry PF01368 DHH, DHH family, score 90.9, E-value 2.7e-24 282459008321 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 282459008322 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 282459008323 DNA-binding site [nucleotide binding]; DNA binding site 282459008324 DRTGG domain; Region: DRTGG; pfam07085 282459008325 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 282459008326 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 282459008327 active site 2 [active] 282459008328 active site 1 [active] 282459008329 Pfam match to entry PF03061 4HBT, Thioesterase superfamily, score 30.0, E-value 5.8e-06 282459008330 Pfam match to entry PF00571 CBS, CBS domain, score 50.0, E-value 5.5e-12 282459008331 Pfam match to entry PF00571 CBS, CBS domain, score 37.6, E-value 2.9e-08 282459008332 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282459008333 Predicted helix-turn-helix motif for SAS1632 with score 1841.000, SD 5.46 at aa 20-41, sequence ISVRKIAKFLNVSEGTAYRAIK 282459008334 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 282459008335 Ligand Binding Site [chemical binding]; other site 282459008336 Pfam match to entry PF00582 Usp, Universal stress protein family, score 66.4, E-value 6.6e-17 282459008337 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 282459008338 metal-dependent hydrolase; Provisional; Region: PRK00685 282459008339 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 74.4, E-value 2.4e-19 282459008340 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 282459008341 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 282459008342 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 282459008343 active site 282459008344 Pfam match to entry PF00557 Peptidase_M24, metallopeptidase family M24, score 230.8, E-value 2e-66 282459008345 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 282459008346 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 282459008347 hexamer interface [polypeptide binding]; other site 282459008348 ligand binding site [chemical binding]; other site 282459008349 putative active site [active] 282459008350 NAD(P) binding site [chemical binding]; other site 282459008351 Pfam match to entry PF01262 AlaDh_PNT_C, Alanine dehydrogenase/PNT, C-terminal domain, score 368.1, E-value 9.8e-108 282459008352 PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. 282459008353 Pfam match to entry PF05222 AlaDh_PNT_N, Alanine dehydrogenase/PNT, N-terminal domain, score 275.5, E-value 7.4e-80 282459008354 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 282459008355 Ligand Binding Site [chemical binding]; other site 282459008356 Pfam match to entry PF00582 Usp, Universal stress protein family, score 81.1, E-value 2.5e-21 282459008357 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 282459008358 propionate/acetate kinase; Provisional; Region: PRK12379 282459008359 Pfam match to entry PF00871 Acetate_kinase, Acetokinase family, score 761.5, E-value 3.6e-226 282459008360 PS00017 ATP/GTP-binding site motif A (P-loop). 282459008361 PS01076 Acetate and butyrate kinases family signature 2. 282459008362 PS00430 TonB-dependent receptor proteins signature 1. 282459008363 PS01075 Acetate and butyrate kinases family signature 1. 282459008364 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 282459008365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459008366 S-adenosylmethionine binding site [chemical binding]; other site 282459008367 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 282459008368 dimer interface [polypeptide binding]; other site 282459008369 catalytic triad [active] 282459008370 peroxidatic and resolving cysteines [active] 282459008371 Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family, score 98.7, E-value 1.2e-26 282459008372 PS01265 Tpx family signature. 282459008373 Signal peptide predicted for SAS1641 by SignalP 2.0 HMM (Signal peptide probabilty 0.864) with cleavage site probability 0.176 between residues 27 and 28; signal peptide 282459008374 hypothetical protein; Provisional; Region: PRK10621 282459008375 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 282459008376 Pfam match to entry PF01925 DUF81, Domain of unknown function DUF81, score 113.4, E-value 4.5e-31 282459008377 7 probable transmembrane helices predicted for SAS1641 by TMHMM2.0 at aa 5-27, 73-95, 100-119, 132-154, 159-178, 191-213 and 223-245 282459008378 PS00061 Short-chain dehydrogenases/reductases family signature. 282459008379 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 282459008380 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 282459008381 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 282459008382 Ligand Binding Site [chemical binding]; other site 282459008383 Pfam match to entry PF02568 ThiI, Thiamine biosynthesis protein (ThiI), score 308.2, E-value 1e-89 282459008384 Pfam match to entry PF02926 THUMP, THUMP domain, score 68.0, E-value 2.1e-17 282459008385 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 282459008386 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 282459008387 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282459008388 catalytic residue [active] 282459008389 Pfam match to entry PF00266 aminotran_5, Aminotransferase class-V, score 266.3, E-value 4.1e-77 282459008390 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 282459008391 Pfam match to entry PF06160 EzrA, Septation ring formation regulator, EzrA, score 955.6, E-value 1.3e-284 282459008392 1 probable transmembrane helix predicted for SAS1644 by TMHMM2.0 at aa 2-24 282459008393 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 282459008394 GAF domain; Region: GAF_2; pfam13185 282459008395 Pfam match to entry PF01590 GAF, GAF domain, score 42.1, E-value 1.3e-09 282459008396 PS01320 Uncharacterized protein family UPF0067 signature. 282459008397 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 282459008398 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 282459008399 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 282459008400 RNA binding surface [nucleotide binding]; other site 282459008401 Pfam match to entry PF00163 Ribosomal_S4, Ribosomal protein S4/S9 N-terminal domain, score 105.5, E-value 1.1e-28 282459008402 Pfam match to entry PF01479 S4, S4 domain, score 85.1, E-value 1.5e-22 282459008403 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 282459008404 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 282459008405 active site 282459008406 catalytic site [active] 282459008407 Pfam match to entry PF03009 GDPD, Glycerophosphoryl diester phosphodiesterase family, score 174.7, E-value 1.5e-49 282459008408 OsmC-like protein; Region: OsmC; cl00767 282459008409 Pfam match to entry PF02566 OsmC, OsmC-like protein, score 92.4, E-value 9.5e-25 282459008410 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 282459008411 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282459008412 catalytic residue [active] 282459008413 Pfam match to entry PF00266 aminotran_5, Aminotransferase class-V, score 59.7, E-value 6.7e-15 282459008414 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 282459008415 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 282459008416 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 282459008417 ligand binding site [chemical binding]; other site 282459008418 NAD binding site [chemical binding]; other site 282459008419 dimerization interface [polypeptide binding]; other site 282459008420 catalytic site [active] 282459008421 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 282459008422 putative L-serine binding site [chemical binding]; other site 282459008423 Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 115.5, E-value 1e-31 282459008424 Pfam match to entry PF02826 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 214.0, E-value 2.4e-61 282459008425 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 282459008426 Pfam match to entry PF01842 ACT, ACT domain, score 42.1, E-value 1.3e-09 282459008427 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 282459008428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459008429 motif II; other site 282459008430 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 7.4, E-value 0.007 282459008431 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 282459008432 Signal peptide predicted for SAS1652 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.658 between residues 37 and 38; signal peptide 282459008433 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282459008434 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282459008435 active site turn [active] 282459008436 phosphorylation site [posttranslational modification] 282459008437 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 61.7, E-value 1.6e-15 282459008438 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282459008439 11 probable transmembrane helices predicted for SAS1652 by TMHMM2.0 at aa 15-37, 44-66, 76-93, 114-133, 153-175, 187-206, 241-263, 276-293, 298-320, 325-342 and 352-374 282459008440 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 257.5, E-value 1.9e-74 282459008441 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 282459008442 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 282459008443 putative acyl-acceptor binding pocket; other site 282459008444 Pfam match to entry PF01553 Acyltransferase, Acyltransferase, score 87.7, E-value 2.5e-23 282459008445 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 282459008446 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 282459008447 protein binding site [polypeptide binding]; other site 282459008448 1 probable transmembrane helix predicted for SAS1654 by TMHMM2.0 at aa 27-49 282459008449 Pfam match to entry PF00089 trypsin, Trypsin, score 65.8, E-value 9.9e-17 282459008450 Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF), score 20.0, E-value 0.0059 282459008451 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 282459008452 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 282459008453 active site 282459008454 HIGH motif; other site 282459008455 dimer interface [polypeptide binding]; other site 282459008456 KMSKS motif; other site 282459008457 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 282459008458 RNA binding surface [nucleotide binding]; other site 282459008459 Pfam match to entry PF01479 S4, S4 domain, score 39.4, E-value 8.6e-09 282459008460 Pfam match to entry PF00579 tRNA-synt_1b, tRNA synthetases class I (W and Y), score 377.8, E-value 1.2e-110 282459008461 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282459008462 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 282459008463 Transglycosylase; Region: Transgly; pfam00912 282459008464 1 probable transmembrane helix predicted for SAS1656 by TMHMM2.0 at aa 27-49 282459008465 Pfam match to entry PF00912 Transglycosyl, Transglycosylase, score 166.5, E-value 4.5e-47 282459008466 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 282459008467 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 282459008468 Signal peptide predicted for SAS1657 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 40 and 41; signal peptide 282459008469 NEAr Transporter domain; Region: NEAT; smart00725 282459008470 NEAr Transporter domain; Region: NEAT; smart00725 282459008471 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 282459008472 heme-binding site [chemical binding]; other site 282459008473 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282459008474 Pfam match to entry PF05031 NEAT, Iron Transport-associated domain, score 166.1, E-value 6.3e-47 282459008475 Pfam match to entry PF05031 NEAT, Iron Transport-associated domain, score 185.5, E-value 8.9e-53 282459008476 Pfam match to entry PF05031 NEAT, Iron Transport-associated domain, score 166.3, E-value 5.5e-47 282459008477 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 31.6, E-value 1.9e-06 282459008478 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 282459008479 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 282459008480 Potassium binding sites [ion binding]; other site 282459008481 Cesium cation binding sites [ion binding]; other site 282459008482 Pfam match to entry PF01268 FTHFS, Formate--tetrahydrofolate ligase, score 1067.3, E-value 0 282459008483 PS00722 Formate--tetrahydrofolate ligase signature 2. 282459008484 acetyl-CoA synthetase; Provisional; Region: PRK04319 282459008485 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 282459008486 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 282459008487 active site 282459008488 acyl-activating enzyme (AAE) consensus motif; other site 282459008489 putative CoA binding site [chemical binding]; other site 282459008490 AMP binding site [chemical binding]; other site 282459008491 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 435.9, E-value 3.8e-128 282459008492 PS00455 AMP-binding domain signature. 282459008493 1 probable transmembrane helix predicted for SAS1659 by TMHMM2.0 at aa 112-134 282459008494 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 282459008495 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 282459008496 active site 282459008497 Zn binding site [ion binding]; other site 282459008498 Pfam match to entry PF00850 Hist_deacetyl, Histone deacetylase family, score 464.2, E-value 1.2e-136 282459008499 catabolite control protein A; Region: ccpA; TIGR01481 282459008500 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 282459008501 DNA binding site [nucleotide binding] 282459008502 domain linker motif; other site 282459008503 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 282459008504 dimerization interface [polypeptide binding]; other site 282459008505 effector binding site; other site 282459008506 Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family, score 28.2, E-value 5.2e-06 282459008507 Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, score 50.0, E-value 5.6e-12 282459008508 Predicted helix-turn-helix motif for SAS1662 with score 1741.000, SD 5.12 at aa 3-24, sequence VTIYDVAREARVSMATVSRVVN 282459008509 PS00356 Bacterial regulatory proteins, lacI family signature. 282459008510 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 282459008511 Chorismate mutase type II; Region: CM_2; cl00693 282459008512 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 282459008513 Pfam match to entry PF00793 DAHP_synth_1, DAHP synthetase I family, score 437.5, E-value 1.2e-128 282459008514 Pfam match to entry PF01817 Chorismate_mut, Chorismate mutase, score 64.3, E-value 2.7e-16 282459008515 1 probable transmembrane helix predicted for SAS1664 by TMHMM2.0 at aa 28-45 282459008516 Signal peptide predicted for SAS1665 by SignalP 2.0 HMM (Signal peptide probabilty 0.719) with cleavage site probability 0.289 between residues 28 and 29; signal peptide 282459008517 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 282459008518 Pfam match to entry PF06103 DUF948, Bacterial protein of unknown function (DUF948), score 179.0, E-value 8e-51 282459008519 1 probable transmembrane helix predicted for SAS1665 by TMHMM2.0 at aa 4-26 282459008520 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 282459008521 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 282459008522 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 282459008523 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 282459008524 Pfam match to entry PF02875 Mur_ligase_C, Mur ligase family, glutamate ligase domain, score 100.4, E-value 3.7e-27 282459008525 Pfam match to entry PF01225 Mur_ligase, Mur ligase family, catalytic domain, score 225.0, E-value 1.1e-64 282459008526 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 282459008527 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 282459008528 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 282459008529 Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family, score 274.3, E-value 1.6e-79 282459008530 PS00017 ATP/GTP-binding site motif A (P-loop). 282459008531 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 282459008532 putative tRNA-binding site [nucleotide binding]; other site 282459008533 Pfam match to entry PF01588 tRNA_bind, tRNA binding domain, score 114.0, E-value 2.9e-31 282459008534 hypothetical protein; Provisional; Region: PRK13668 282459008535 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 282459008536 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 282459008537 catalytic residues [active] 282459008538 Pfam match to entry PF00085 thiored, Thioredoxin, score 21.1, E-value 1.2e-07 282459008539 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 282459008540 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 282459008541 oligomer interface [polypeptide binding]; other site 282459008542 active site 282459008543 metal binding site [ion binding]; metal-binding site 282459008544 Pfam match to entry PF05343 Peptidase_M42, M42 glutamyl aminopeptidase, score 486.4, E-value 2.3e-143 282459008545 Predicted small secreted protein [Function unknown]; Region: COG5584 282459008546 1 probable transmembrane helix predicted for SAS1672 by TMHMM2.0 at aa 6-28 282459008547 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 282459008548 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 68.2, E-value 1.8e-17 282459008549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459008550 S-adenosylmethionine binding site [chemical binding]; other site 282459008551 Pfam match to entry PF02390 Methyltransf_4, methyltransferase, score 208.0, E-value 1.5e-59 282459008552 Phosphotransferase enzyme family; Region: APH; pfam01636 282459008553 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 282459008554 active site 282459008555 substrate binding site [chemical binding]; other site 282459008556 ATP binding site [chemical binding]; other site 282459008557 Pfam match to entry PF01636 APH, Phosphotransferase enzyme family, score 136.5, E-value 4.9e-38 282459008558 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 282459008559 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 282459008560 homodimer interface [polypeptide binding]; other site 282459008561 substrate-cofactor binding pocket; other site 282459008562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459008563 catalytic residue [active] 282459008564 Pfam match to entry PF01063 aminotran_4, Aminotransferase class IV, score 401.7, E-value 7.5e-118 282459008565 PS00770 Aminotransferases class-IV signature. 282459008566 dipeptidase PepV; Reviewed; Region: PRK07318 282459008567 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 282459008568 active site 282459008569 metal binding site [ion binding]; metal-binding site 282459008570 Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40, score 249.5, E-value 4.7e-72 282459008571 Signal peptide predicted for SAS1678 by SignalP 2.0 HMM (Signal peptide probabilty 0.802) with cleavage site probability 0.434 between residues 24 and 25; signal peptide 282459008572 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 282459008573 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 282459008574 RNA binding surface [nucleotide binding]; other site 282459008575 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 282459008576 active site 282459008577 uracil binding [chemical binding]; other site 282459008578 Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase, score 56.5, E-value 5.9e-14 282459008579 PS01149 Rsu family of pseudouridine synthase signature. 282459008580 Pfam match to entry PF01479 S4, S4 domain, score 51.1, E-value 2.5e-12 282459008581 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 282459008582 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 282459008583 14 probable transmembrane helices predicted for SAS1680 by TMHMM2.0 at aa 12-34, 49-71, 91-113, 133-155, 176-198, 202-221, 250-267, 303-322, 342-364, 388-410, 417-439, 443-462, 475-497 and 507-529 282459008584 Pfam match to entry PF01943 Polysacc_synt, Polysaccharide biosynthesis protein, score 52.5, E-value 9.7e-13 282459008585 Signal peptide predicted for SAS1681 by SignalP 2.0 HMM (Signal peptide probabilty 0.793) with cleavage site probability 0.315 between residues 22 and 23; signal peptide 282459008586 HI0933-like protein; Region: HI0933_like; pfam03486 282459008587 Pfam match to entry PF03486 HI0933_like, HI0933-like protein, score 735.1, E-value 3.1e-218 282459008588 Signal peptide predicted for SAS1682 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.696 between residues 37 and 38; signal peptide 282459008589 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282459008590 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 282459008591 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282459008592 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282459008593 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282459008594 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282459008595 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282459008596 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282459008597 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282459008598 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282459008599 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282459008600 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282459008601 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282459008602 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282459008603 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282459008604 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 282459008605 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282459008606 Pfam match to entry PF01468 GA, GA module, score 7.2, E-value 0.3 282459008607 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 45.5, E-value 1.3e-10 282459008608 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 282459008609 active site residue [active] 282459008610 Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain, score 38.7, E-value 1.4e-08 282459008611 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 282459008612 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 282459008613 HIGH motif; other site 282459008614 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 282459008615 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 282459008616 active site 282459008617 KMSKS motif; other site 282459008618 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 282459008619 tRNA binding surface [nucleotide binding]; other site 282459008620 Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V), score 753.1, E-value 1.2e-223 282459008621 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 282459008622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459008623 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282459008624 putative substrate translocation pore; other site 282459008625 12 probable transmembrane helices predicted for SAS1685 by TMHMM2.0 at aa 7-25, 40-62, 69-91, 96-118, 131-153, 159-181, 202-224, 244-266, 275-292, 297-319, 332-354 and 364-381 282459008626 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 282459008627 Pfam match to entry PF04055 Radical_SAM, Radical SAM superfamily, score 54.0, E-value 3.3e-13 282459008628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459008629 S-adenosylmethionine binding site [chemical binding]; other site 282459008630 PS00430 TonB-dependent receptor proteins signature 1. 282459008631 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282459008632 1 probable transmembrane helix predicted for SAS1688 by TMHMM2.0 at aa 5-27 282459008633 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 282459008634 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 282459008635 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 282459008636 Pfam match to entry PF01619 Pro_dh, Proline dehydrogenase, score 205.6, E-value 8e-59 282459008637 1 probable transmembrane helix predicted for SAS1690 by TMHMM2.0 at aa 310-327 282459008638 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 282459008639 homopentamer interface [polypeptide binding]; other site 282459008640 active site 282459008641 Pfam match to entry PF00885 DMRL_synthase, 6,7-dimethyl-8-ribityllumazine synthase, score 291.9, E-value 8.4e-85 282459008642 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 282459008643 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 282459008644 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 282459008645 dimerization interface [polypeptide binding]; other site 282459008646 active site 282459008647 Pfam match to entry PF00925 GTP_cyclohydro2, GTP cyclohydrolase II, score 269.5, E-value 4.8e-78 282459008648 Pfam match to entry PF00926 DHBP_synthase, 3,4-dihydroxy-2-butanone 4-phosphate synthase, score 363.2, E-value 2.9e-106 282459008649 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 282459008650 Lumazine binding domain; Region: Lum_binding; pfam00677 282459008651 Lumazine binding domain; Region: Lum_binding; pfam00677 282459008652 Pfam match to entry PF00677 Lum_binding, Lumazine binding domain, score 85.4, E-value 1.2e-22 282459008653 Pfam match to entry PF00677 Lum_binding, Lumazine binding domain, score 69.7, E-value 6.5e-18 282459008654 PS00430 TonB-dependent receptor proteins signature 1. 282459008655 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 282459008656 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 282459008657 catalytic motif [active] 282459008658 Zn binding site [ion binding]; other site 282459008659 RibD C-terminal domain; Region: RibD_C; cl17279 282459008660 Pfam match to entry PF01872 RibD_C, RibD C-terminal domain, score 135.3, E-value 1.2e-37 282459008661 Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region, score 98.4, E-value 1.4e-26 282459008662 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 282459008663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 282459008664 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 282459008665 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 282459008666 dimerization interface [polypeptide binding]; other site 282459008667 putative DNA binding site [nucleotide binding]; other site 282459008668 putative Zn2+ binding site [ion binding]; other site 282459008669 Pfam match to entry PF01022 HTH_5, Bacterial regulatory protein, arsR family, score 95.4, E-value 1.2e-25 282459008670 PS00846 Bacterial regulatory proteins, arsR family signature. 282459008671 Signal peptide predicted for SAS1697 by SignalP 2.0 HMM (Signal peptide probabilty 0.684) with cleavage site probability 0.234 between residues 30 and 31; signal peptide 282459008672 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 282459008673 arsenical pump membrane protein; Provisional; Region: PRK15445 282459008674 transmembrane helices; other site 282459008675 11 probable transmembrane helices predicted for SAS1697 by TMHMM2.0 at aa 2-19, 24-46, 53-72, 98-120, 141-163, 178-200, 221-243, 248-265, 285-307, 317-336 and 407-429 282459008676 Pfam match to entry PF02040 ArsB, Arsenical pump membrane protein, score 981.0, E-value 3e-292 282459008677 Signal peptide predicted for SAS1698 by SignalP 2.0 HMM (Signal peptide probabilty 0.974) with cleavage site probability 0.344 between residues 37 and 38; signal peptide 282459008678 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 282459008679 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 282459008680 Pfam match to entry PF01832 Amidase_4, Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase, score 110.7, E-value 3e-30 282459008681 1 probable transmembrane helix predicted for SAS1698 by TMHMM2.0 at aa 7-29 282459008682 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 282459008683 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 282459008684 DNA binding residues [nucleotide binding] 282459008685 Pfam match to entry PF04542 sigma70_r2, Sigma-70 region 2, score 23.6, E-value 0.00049 282459008686 Predicted helix-turn-helix motif for SAS1700 with score 1109.000, SD 2.96 at aa 124-145, sequence YKQFEIAEIMSLSLSTIKLIKM 282459008687 2 probable transmembrane helices predicted for SAS1702 by TMHMM2.0 at aa 67-89 and 109-128 282459008688 Ortholog of S. aureus MRSA252 (BX571856) SAR1862; Similar to Streptococcus pneumoniae conserved domain protein sp2116 SWALL:Q97ND4 (EMBL:AE007500) (213 aa) fasta scores: E(): 1.4e-08, 28.03% id in 214 aa, and to Bacillus anthracis caax amino terminal protease family protein ba0265 SWALL:Q81VE3 (EMBL:AE017024) (235 aa) fasta scores: E(): 2.7e-07, 29.71% id in 212 aa. CDS contains a frameshift after codon 26. Frameshift occurs at a poly T pentamer;CAAX amino terminal protease family protein (pseudogene) 282459008689 7 probable transmembrane helices predicted for SAS1703 by TMHMM2.0 at aa 17-39, 43-65, 72-94, 114-133, 146-160, 165-184 and 191-209 282459008690 Pfam match to entry PF02517 Abi, CAAX amino terminal protease family, score 73.7, E-value 4e-19 282459008691 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 282459008692 active site 282459008693 intersubunit interactions; other site 282459008694 catalytic residue [active] 282459008695 Pfam match to entry PF00923 Transaldolase, Transaldolase, score 49.0, E-value 6.5e-14 282459008696 Signal peptide predicted for SAS1705 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.765 between residues 28 and 29; signal peptide 282459008697 3 probable transmembrane helices predicted for SAS1705 by TMHMM2.0 at aa 7-29, 34-56 and 77-99 282459008698 camphor resistance protein CrcB; Provisional; Region: PRK14201 282459008699 4 probable transmembrane helices predicted for SAS1706 by TMHMM2.0 at aa 24-46, 59-81, 91-113 and 118-140 282459008700 Pfam match to entry PF02537 CRCB, CrcB-like protein, score 102.3, E-value 1e-27 282459008701 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 282459008702 Pfam match to entry PF02537 CRCB, CrcB-like protein, score 78.3, E-value 1.6e-20 282459008703 4 probable transmembrane helices predicted for SAS1707 by TMHMM2.0 at aa 4-22, 35-54, 58-80 and 93-115 282459008704 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 282459008705 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 282459008706 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 282459008707 active site 282459008708 catalytic tetrad [active] 282459008709 Pfam match to entry PF00248 aldo_ket_red, Aldo/keto reductase family, score 413.7, E-value 1.8e-121 282459008710 PS00063 Aldo/keto reductase family active site signature. 282459008711 Predicted helix-turn-helix motif for SAS1709 with score 1298.000, SD 3.61 at aa 202-223, sequence ETIKDIAQELGKSPAQVVLRWN 282459008712 PS00062 Aldo/keto reductase family signature 2. 282459008713 PS00798 Aldo/keto reductase family signature 1. 282459008714 Signal peptide predicted for SAS1710 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.432 between residues 32 and 33; signal peptide 282459008715 1 probable transmembrane helix predicted for SAS1710 by TMHMM2.0 at aa 7-29 282459008716 S-adenosylmethionine synthetase; Validated; Region: PRK05250 282459008717 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 282459008718 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 282459008719 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 282459008720 Pfam match to entry PF02773 S-AdoMet_syntD3, S-adenosylmethionine synthetase, C-terminal domain, score 310.8, E-value 1.7e-90 282459008721 PS00377 S-adenosylmethionine synthetase signature 2. 282459008722 Pfam match to entry PF02772 S-AdoMet_syntD2, S-adenosylmethionine synthetase, central domain, score 303.6, E-value 2.5e-88 282459008723 PS00376 S-adenosylmethionine synthetase signature 1. 282459008724 Pfam match to entry PF00438 S-AdoMet_synt, S-adenosylmethionine synthetase, N-terminal domain, score 215.1, E-value 1.1e-61 282459008725 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 282459008726 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 282459008727 active site 282459008728 substrate-binding site [chemical binding]; other site 282459008729 metal-binding site [ion binding] 282459008730 ATP binding site [chemical binding]; other site 282459008731 Pfam match to entry PF01293 PEPCK_ATP, Phosphoenolpyruvate carboxykinase, score 1211.2, E-value 0 282459008732 PS00017 ATP/GTP-binding site motif A (P-loop). 282459008733 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 282459008734 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 282459008735 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 282459008736 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 282459008737 nudix motif; other site 282459008738 Pfam match to entry PF00293 NUDIX, NUDIX domain, score 34.4, E-value 2.7e-07 282459008739 PS00893 mutT domain signature. 282459008740 Haemolytic domain; Region: Haemolytic; pfam01809 282459008741 Pfam match to entry PF01809 DUF37, Domain of unknown function DUF37, score 145.5, E-value 9.8e-41 282459008742 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 282459008743 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 282459008744 metal binding site [ion binding]; metal-binding site 282459008745 substrate binding pocket [chemical binding]; other site 282459008746 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 282459008747 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 282459008748 acyl-activating enzyme (AAE) consensus motif; other site 282459008749 putative AMP binding site [chemical binding]; other site 282459008750 putative active site [active] 282459008751 putative CoA binding site [chemical binding]; other site 282459008752 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 299.0, E-value 6e-87 282459008753 Signal peptide predicted for SAS1718 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.320 between residues 35 and 36; signal peptide 282459008754 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459008755 Signal peptide predicted for SAS1719 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.352 between residues 49 and 50; signal peptide 282459008756 Excalibur calcium-binding domain; Region: Excalibur; smart00894 282459008757 1 probable transmembrane helix predicted for SAS1719 by TMHMM2.0 at aa 20-42 282459008758 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459008759 Pfam match to entry PF05901 Excalibur, Excalibur domain, score 75.9, E-value 8.6e-20 282459008760 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 282459008761 1 probable transmembrane helix predicted for SAS1720 by TMHMM2.0 at aa 39-61 282459008762 Signal peptide predicted for SAS1721 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.468 between residues 20 and 21; signal peptide 282459008763 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459008764 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 282459008765 Domain of unknown function (DUF955); Region: DUF955; pfam06114 282459008766 Signal peptide predicted for SAS1725 by SignalP 2.0 HMM (Signal peptide probabilty 0.974) with cleavage site probability 0.481 between residues 31 and 32; signal peptide 282459008767 2 probable transmembrane helices predicted for SAS1725 by TMHMM2.0 at aa 7-24 and 34-56 282459008768 1 probable transmembrane helix predicted for SAS1726 by TMHMM2.0 at aa 67-89 282459008769 Probable gene remnant. Similar to the N-terminal regions of Bacillus halodurans transposase bh3444 and bh0335 and bh0689 and bh2343 and bh3417 SWALL:Q9JWR5 (EMBL:AP001518) (261 aa) fasta scores: E(): 2.3e-05, 41.17% id in 68 aa, and Enterococcus faecalis hypothetical 32.4 kDa protein SWALL:Q9AKZ7 (EMBL:X92945) (278 aa) fasta scores: E(): 0.00014, 38.23% id in 68 aa; transposase (fragment) 282459008770 Ortholog of S. aureus MRSA252 (BX571856) SAR0081; Similar to Bacillus halodurans transposase bh3445 and bh0334 and bh0688 and bh2342 and bh3418 SWALL:Q9JWP9 (EMBL:AP001518) (94 aa) fasta scores: E(): 2.8e-19, 62.63% id in 91 aa, and to Shigella dysenteriae transposase InsN for insertion sequence element IS911 insN SWALL:INSN_SHIDY (SWALL:P39213) (112 aa) fasta scores: E(): 0.0061, 31.86% id in 91 aa; transposase (pseudogene) 282459008771 Pfam match to entry PF01527 Transposase_8, Transposase, score 30.4, E-value 2.2e-08 282459008772 Ortholog of S. aureus MRSA252 (BX571856) SAR1893; Similar to Bacillus cereus hypothetical protein bc3278 SWALL:Q81B99 (EMBL:AE017008) (127 aa) fasta scores: E(): 1.1e-09, 42.18% id in 128 aa, and to Streptococcus agalactiae hypothetical protein gbs1983 SWALL:Q8E2Y0 (EMBL:AL766855) (121 aa) fasta scores: E(): 1, 27.04% id in 122 aa. CDS contains a nonsense mutation (ochre) after codon 30; exported protein (pseudogene) 282459008773 1 probable transmembrane helix predicted for SAS1728 by TMHMM2.0 at aa 5-22 282459008774 Poor database matches. C-terminal region is weakly similar to an internal region of Bacteroides thetaiotaomicron conserved hypothetical protein bt2577 SWALL:Q8A4M2 (EMBL:AE016936) (1407 aa) fasta scores: E(): 3.2e-10, 21.86% id in 1235 aa. CDS contains a frameshift after codon 452;conserved hypothetical protein (pseudogene) 282459008775 PS00017 ATP/GTP-binding site motif A (P-loop). 282459008776 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 282459008777 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 282459008778 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 282459008779 Pfam match to entry PF01420 Methylase_S, Type I restriction modification DNA specificity domain, score 63.8, E-value 3.9e-16 282459008780 Pfam match to entry PF01420 Methylase_S, Type I restriction modification DNA specificity domain, score 82.4, E-value 9.6e-22 282459008781 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 282459008782 HsdM N-terminal domain; Region: HsdM_N; pfam12161 282459008783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459008784 S-adenosylmethionine binding site [chemical binding]; other site 282459008785 Pfam match to entry PF02384 N6_Mtase, N-6 DNA Methylase, score 261.1, E-value 1.5e-75 282459008786 PS00092 N-6 Adenine-specific DNA methylases signature. 282459008787 Pfam match to entry PF02506 Methylase_M, Type I restriction modification system, M protein, score 271.8, E-value 9.4e-79 282459008788 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 282459008789 Signal peptide predicted for SAS1733 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.932 between residues 36 and 37; signal peptide 282459008790 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 282459008791 Pfam match to entry PF00089 trypsin, Trypsin, score 56.3, E-value 7.1e-14 282459008792 PS00672 Serine proteases, V8 family, histidine active site. 282459008793 2 probable transmembrane helices predicted for SAS1733 by TMHMM2.0 at aa 5-27 and 49-71 282459008794 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 282459008795 Signal peptide predicted for SAS1734 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.404 between residues 36 and 37; signal peptide 282459008796 Pfam match to entry PF00089 trypsin, Trypsin, score 104.2, E-value 2.7e-28 282459008797 PS00672 Serine proteases, V8 family, histidine active site. 282459008798 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 282459008799 Signal peptide predicted for SAS1735 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.934 between residues 36 and 37; signal peptide 282459008800 Pfam match to entry PF00089 trypsin, Trypsin, score 111.2, E-value 2e-30 282459008801 PS00672 Serine proteases, V8 family, histidine active site. 282459008802 1 probable transmembrane helix predicted for SAS1735 by TMHMM2.0 at aa 5-27 282459008803 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 282459008804 Signal peptide predicted for SAS1736 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.936 between residues 35 and 36; signal peptide 282459008805 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 282459008806 Pfam match to entry PF00089 trypsin, Trypsin, score 73.6, E-value 4.3e-19 282459008807 PS00672 Serine proteases, V8 family, histidine active site. 282459008808 Signal peptide predicted for SAS1738 by SignalP 2.0 HMM (Signal peptide probabilty 0.979) with cleavage site probability 0.308 between residues 42 and 43; signal peptide 282459008809 PS00097 Aspartate and ornithine carbamoyltransferases signature. 282459008810 6 probable transmembrane helices predicted for SAS1739 by TMHMM2.0 at aa 21-43, 53-75, 95-117, 127-149, 156-178 and 201-223 282459008811 Signal peptide predicted for SAS1740 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.392 between residues 40 and 41; signal peptide 282459008812 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 282459008813 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 282459008814 7 probable transmembrane helices predicted for SAS1740 by TMHMM2.0 at aa 13-35, 50-72, 104-126, 136-158, 163-185, 195-214 and 227-244 282459008815 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 282459008816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282459008817 Walker A/P-loop; other site 282459008818 ATP binding site [chemical binding]; other site 282459008819 Q-loop/lid; other site 282459008820 ABC transporter signature motif; other site 282459008821 Walker B; other site 282459008822 D-loop; other site 282459008823 H-loop/switch region; other site 282459008824 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 173.0, E-value 5.3e-49 282459008825 PS00211 ABC transporters family signature. 282459008826 PS00017 ATP/GTP-binding site motif A (P-loop). 282459008827 Signal peptide predicted for SAS1742 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.870 between residues 27 and 28; signal peptide 282459008828 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 282459008829 active site 282459008830 catalytic triad [active] 282459008831 Pfam match to entry PF00082 Peptidase_S8, Subtilase family, score 184.3, E-value 2.1e-52 282459008832 PS00138 Serine proteases, subtilase family, serine active site. 282459008833 PS00136 Serine proteases, subtilase family, aspartic acid active site. 282459008834 1 probable transmembrane helix predicted for SAS1742 by TMHMM2.0 at aa 7-26 282459008835 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 282459008836 Flavoprotein; Region: Flavoprotein; pfam02441 282459008837 Pfam match to entry PF02441 Flavoprotein, Flavoprotein, score 106.2, E-value 6.7e-29 282459008838 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 282459008839 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 282459008840 active site 282459008841 zinc binding site [ion binding]; other site 282459008842 Pfam match to entry PF05500 NisC, NisC-like family, score 756.0, E-value 1.6e-224 282459008843 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 282459008844 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 282459008845 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 282459008846 Pfam match to entry PF04738 Lant_dehyd_C, Lantibiotic dehydratase, C terminus, score 549.6, E-value 2.1e-162 282459008847 Pfam match to entry PF04737 Lant_dehyd_N, Lantibiotic dehydratase, N terminus, score 153.3, E-value 4.4e-43 282459008848 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 282459008849 Pfam match to entry PF02052 Gallidermin, Gallidermin, score 69.2, E-value 8.9e-18 282459008850 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 282459008851 Pfam match to entry PF02052 Gallidermin, Gallidermin, score 39.9, E-value 6.2e-09 282459008852 Signal peptide predicted for SAS1748 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.730 between residues 26 and 27; signal peptide 282459008853 beta-channel forming cytolysin; Region: hlyII; TIGR01002 282459008854 Pfam match to entry PF01117 Aerolysin, Aerolysin/Hemolysin/Leukocidin toxin, score 375.8, E-value 4.6e-110 282459008855 Signal peptide predicted for SAS1749 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.553 between residues 28 and 29; signal peptide 282459008856 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 282459008857 Pfam match to entry PF01117 Aerolysin, Aerolysin/Hemolysin/Leukocidin toxin, score 352.0, E-value 6.7e-103 282459008858 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 282459008859 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 282459008860 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 282459008861 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 282459008862 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 282459008863 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 282459008864 Pfam match to entry PF01593 Amino_oxidase, Flavin containing amine oxidoreductase, score 103.3, E-value 4.9e-28 282459008865 ferrochelatase; Provisional; Region: PRK12435 282459008866 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 282459008867 C-terminal domain interface [polypeptide binding]; other site 282459008868 active site 282459008869 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 282459008870 active site 282459008871 N-terminal domain interface [polypeptide binding]; other site 282459008872 Pfam match to entry PF00762 Ferrochelatase, Ferrochelatase, score 292.8, E-value 4.4e-85 282459008873 PS00435 Peroxidases proximal heme-ligand signature. 282459008874 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 282459008875 substrate binding site [chemical binding]; other site 282459008876 active site 282459008877 Pfam match to entry PF01208 URO-D, Uroporphyrinogen decarboxylase (URO-D), score 543.7, E-value 1.3e-160 282459008878 PS00907 Uroporphyrinogen decarboxylase signature 2. 282459008879 PS00906 Uroporphyrinogen decarboxylase signature 1. 282459008880 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 282459008881 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 282459008882 Pfam match to entry PF05975 EcsB, Bacterial ABC transporter protein EcsB, score 735.5, E-value 2.4e-218 282459008883 10 probable transmembrane helices predicted for SAS1757 by TMHMM2.0 at aa 26-48, 58-80, 101-123, 133-151, 164-183, 187-204, 285-302, 306-328, 353-371 and 376-395 282459008884 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 282459008885 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 282459008886 Walker A/P-loop; other site 282459008887 ATP binding site [chemical binding]; other site 282459008888 Q-loop/lid; other site 282459008889 ABC transporter signature motif; other site 282459008890 Walker B; other site 282459008891 D-loop; other site 282459008892 H-loop/switch region; other site 282459008893 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 176.6, E-value 4.4e-50 282459008894 PS00211 ABC transporters family signature. 282459008895 PS00017 ATP/GTP-binding site motif A (P-loop). 282459008896 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 282459008897 HIT family signature motif; other site 282459008898 catalytic residue [active] 282459008899 Pfam match to entry PF01230 HIT, HIT domain, score 145.4, E-value 1.1e-40 282459008900 PS00892 HIT family signature. 282459008901 Signal peptide predicted for SAS1760 by SignalP 2.0 HMM (Signal peptide probabilty 0.946) with cleavage site probability 0.507 between residues 24 and 25; signal peptide 282459008902 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 282459008903 1 probable transmembrane helix predicted for SAS1760 by TMHMM2.0 at aa 5-22 282459008904 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 282459008905 4 probable transmembrane helices predicted for SAS1761 by TMHMM2.0 at aa 19-41, 51-73, 105-127 and 137-159 282459008906 Signal peptide predicted for SAS1762 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.674 between residues 25 and 26; signal peptide 282459008907 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 282459008908 SurA N-terminal domain; Region: SurA_N_3; cl07813 282459008909 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 282459008910 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459008911 Pfam match to entry PF00639 Rotamase, PPIC-type PPIASE domain, score 100.6, E-value 3.3e-27 282459008912 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 282459008913 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 282459008914 generic binding surface II; other site 282459008915 generic binding surface I; other site 282459008916 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 282459008917 Zn2+ binding site [ion binding]; other site 282459008918 Mg2+ binding site [ion binding]; other site 282459008919 Pfam match to entry PF01966 HD, HD domain, score 54.3, E-value 2.7e-13 282459008920 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain, score 35.7, E-value 1.1e-07 282459008921 Uncharacterized conserved protein [Function unknown]; Region: COG4717 282459008922 P-loop containing region of AAA domain; Region: AAA_29; cl17516 282459008923 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 282459008924 2 probable transmembrane helices predicted for SAS1764 by TMHMM2.0 at aa 465-482 and 487-506 282459008925 PS00017 ATP/GTP-binding site motif A (P-loop). 282459008926 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 282459008927 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 282459008928 active site 282459008929 metal binding site [ion binding]; metal-binding site 282459008930 DNA binding site [nucleotide binding] 282459008931 Pfam match to entry PF00149 Metallophos, Calcineurin-like phosphoesterase, score 75.3, E-value 1.3e-19 282459008932 hypothetical protein; Provisional; Region: PRK13676 282459008933 Pfam match to entry PF06133 DUF964, Protein of unknown function (DUF964), score 211.5, E-value 1.3e-60 282459008934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 282459008935 Pfam match to entry PF04286 DUF445, Protein of unknown function (DUF445), score 540.9, E-value 9e-160 282459008936 2 probable transmembrane helices predicted for SAS1767 by TMHMM2.0 at aa 4-26 and 351-373 282459008937 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 282459008938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282459008939 non-specific DNA binding site [nucleotide binding]; other site 282459008940 salt bridge; other site 282459008941 sequence-specific DNA binding site [nucleotide binding]; other site 282459008942 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 26.5, E-value 6.7e-05 282459008943 Predicted helix-turn-helix motif for SAS1768 with score 983.000, SD 2.53 at aa 23-44, sequence YTQDTMAQTIGLSKKTLVQIEK 282459008944 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 282459008945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459008946 active site 282459008947 phosphorylation site [posttranslational modification] 282459008948 intermolecular recognition site; other site 282459008949 dimerization interface [polypeptide binding]; other site 282459008950 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 282459008951 DNA binding residues [nucleotide binding] 282459008952 dimerization interface [polypeptide binding]; other site 282459008953 Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family, score 93.0, E-value 6.3e-25 282459008954 PS00622 Bacterial regulatory proteins, luxR family signature. 282459008955 Predicted helix-turn-helix motif for SAS1769 with score 1251.000, SD 3.45 at aa 162-183, sequence KTNKEIAETLFVSEKTIKTHVS 282459008956 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 118.3, E-value 1.5e-32 282459008957 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 282459008958 GAF domain; Region: GAF_3; pfam13492 282459008959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 282459008960 Histidine kinase; Region: HisKA_3; pfam07730 282459008961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459008962 ATP binding site [chemical binding]; other site 282459008963 Mg2+ binding site [ion binding]; other site 282459008964 G-X-G motif; other site 282459008965 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 54.2, E-value 2.9e-13 282459008966 Pfam match to entry PF01590 GAF, GAF domain, score 25.4, E-value 2e-06 282459008967 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 282459008968 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 282459008969 active site 282459008970 Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase, score 128.4, E-value 1.4e-35 282459008971 fumarate hydratase; Reviewed; Region: fumC; PRK00485 282459008972 Class II fumarases; Region: Fumarase_classII; cd01362 282459008973 active site 282459008974 tetramer interface [polypeptide binding]; other site 282459008975 Pfam match to entry PF00206 lyase_1, Lyase, score 532.6, E-value 2.8e-157 282459008976 PS00163 Fumarate lyases signature. 282459008977 3 probable transmembrane helices predicted for SAS1773 by TMHMM2.0 at aa 10-32, 66-85 and 100-122 282459008978 1 probable transmembrane helix predicted for SAS1774 by TMHMM2.0 at aa 21-43 282459008979 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 282459008980 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 282459008981 active site 282459008982 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 282459008983 Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family, score 171.8, E-value 1.2e-48 282459008984 epoxyqueuosine reductase; Region: TIGR00276 282459008985 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 282459008986 HEAT repeats; Region: HEAT_2; pfam13646 282459008987 Pfam match to entry PF00037 fer4, 4Fe-4S binding domain, score 14.4, E-value 0.0014 282459008988 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 282459008989 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 282459008990 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 282459008991 Walker A/P-loop; other site 282459008992 ATP binding site [chemical binding]; other site 282459008993 Q-loop/lid; other site 282459008994 ABC transporter signature motif; other site 282459008995 Walker B; other site 282459008996 D-loop; other site 282459008997 H-loop/switch region; other site 282459008998 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 252.1, E-value 7.8e-73 282459008999 PS00211 ABC transporters family signature. 282459009000 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009001 Signal peptide predicted for SAS1781 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 28 and 29; signal peptide 282459009002 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 282459009003 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 282459009004 substrate binding pocket [chemical binding]; other site 282459009005 membrane-bound complex binding site; other site 282459009006 hinge residues; other site 282459009007 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 282459009008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459009009 dimer interface [polypeptide binding]; other site 282459009010 conserved gate region; other site 282459009011 putative PBP binding loops; other site 282459009012 ABC-ATPase subunit interface; other site 282459009013 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 127.4, E-value 2.8e-35 282459009014 3 probable transmembrane helices predicted for SAS1781 by TMHMM2.0 at aa 287-309, 334-356 and 448-470 282459009015 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282459009016 Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3, score 241.0, E-value 1.8e-69 282459009017 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 282459009018 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 282459009019 10 probable transmembrane helices predicted for SAS1782 by TMHMM2.0 at aa 12-34, 49-71, 78-97, 107-129, 136-158, 178-200, 207-229, 233-255, 258-280 and 309-331 282459009020 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 78.0, E-value 2e-20 282459009021 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 282459009022 metal binding site 2 [ion binding]; metal-binding site 282459009023 putative DNA binding helix; other site 282459009024 metal binding site 1 [ion binding]; metal-binding site 282459009025 dimer interface [polypeptide binding]; other site 282459009026 structural Zn2+ binding site [ion binding]; other site 282459009027 Pfam match to entry PF01475 FUR, Ferric uptake regulator family, score 191.2, E-value 1.7e-54 282459009028 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 282459009029 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 282459009030 putative ligand binding site [chemical binding]; other site 282459009031 NAD binding site [chemical binding]; other site 282459009032 catalytic site [active] 282459009033 Pfam match to entry PF02826 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 74.2, E-value 2.9e-19 282459009034 Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 61.1, E-value 2.4e-15 282459009035 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 282459009036 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 282459009037 catalytic triad [active] 282459009038 Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family, score 96.1, E-value 7.3e-26 282459009039 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 282459009040 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 282459009041 inhibitor-cofactor binding pocket; inhibition site 282459009042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459009043 catalytic residue [active] 282459009044 Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III, score 335.8, E-value 5.2e-98 282459009045 Predicted membrane protein [Function unknown]; Region: COG4129 282459009046 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 282459009047 Signal peptide predicted for SAS1787 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.586 between residues 30 and 31; signal peptide 282459009048 Pfam match to entry PF06081 DUF939, Bacterial protein of unknown function (DUF939), score 103.2, E-value 5.4e-28 282459009049 4 probable transmembrane helices predicted for SAS1787 by TMHMM2.0 at aa 7-24, 57-79, 86-108 and 123-145 282459009050 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 282459009051 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 282459009052 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 282459009053 Walker A/P-loop; other site 282459009054 ATP binding site [chemical binding]; other site 282459009055 Q-loop/lid; other site 282459009056 ABC transporter signature motif; other site 282459009057 Walker B; other site 282459009058 D-loop; other site 282459009059 H-loop/switch region; other site 282459009060 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 222.9, E-value 4.9e-64 282459009061 PS00211 ABC transporters family signature. 282459009062 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009063 Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region, score 168.9, E-value 8.9e-48 282459009064 5 probable transmembrane helices predicted for SAS1788 by TMHMM2.0 at aa 19-41, 56-73, 136-158, 163-185 and 260-282 282459009065 hypothetical protein; Provisional; Region: PRK13662 282459009066 Pfam match to entry PF04167 DUF402, Protein of unknown function (DUF402), score 163.7, E-value 3.2e-46 282459009067 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 282459009068 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 282459009069 minor groove reading motif; other site 282459009070 helix-hairpin-helix signature motif; other site 282459009071 substrate binding pocket [chemical binding]; other site 282459009072 active site 282459009073 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 282459009074 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 282459009075 DNA binding and oxoG recognition site [nucleotide binding] 282459009076 Pfam match to entry PF00730 HhH-GPD, HhH-GPD superfamily base excision DNA repair protein, score 58.6, E-value 1.5e-14 282459009077 Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif, score 28.3, E-value 1.9e-05 282459009078 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 282459009079 Signal peptide predicted for SAS1791 by SignalP 2.0 HMM (Signal peptide probabilty 0.730) with cleavage site probability 0.346 between residues 29 and 30; signal peptide 282459009080 Pfam match to entry PF04307 DUF457, Predicted membrane-bound metal-dependent hydrolase (DUF457), score 123.7, E-value 3.5e-34 282459009081 4 probable transmembrane helices predicted for SAS1791 by TMHMM2.0 at aa 65-87, 92-114, 127-149 and 154-171 282459009082 Signal peptide predicted for SAS1792 by SignalP 2.0 HMM (Signal peptide probabilty 0.617) with cleavage site probability 0.332 between residues 49 and 50; signal peptide 282459009083 7 probable transmembrane helices predicted for SAS1792 by TMHMM2.0 at aa 29-51, 61-83, 95-117, 132-154, 166-185, 195-217 and 224-246 282459009084 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 282459009085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282459009086 Walker A/P-loop; other site 282459009087 ATP binding site [chemical binding]; other site 282459009088 Q-loop/lid; other site 282459009089 ABC transporter signature motif; other site 282459009090 Walker B; other site 282459009091 H-loop/switch region; other site 282459009092 1 probable transmembrane helix predicted for SAS1793 by TMHMM2.0 at aa 285-307 282459009093 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 282459009094 recombination regulator RecX; Provisional; Region: recX; PRK14135 282459009095 Pfam match to entry PF02631 RecX, RecX family, score 12.7, E-value 0.00054 282459009096 glycosyltransferase; Provisional; Region: PRK13481 282459009097 Transglycosylase; Region: Transgly; pfam00912 282459009098 Pfam match to entry PF00912 Transglycosyl, Transglycosylase, score 170.8, E-value 2.4e-48 282459009099 1 probable transmembrane helix predicted for SAS1796 by TMHMM2.0 at aa 42-64 282459009100 intracellular protease, PfpI family; Region: PfpI; TIGR01382 282459009101 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 282459009102 proposed catalytic triad [active] 282459009103 conserved cys residue [active] 282459009104 Pfam match to entry PF01965 DJ-1_PfpI, DJ-1/PfpI family, score 180.5, E-value 2.8e-51 282459009105 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 282459009106 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282459009107 FeS/SAM binding site; other site 282459009108 YfkB-like domain; Region: YfkB; pfam08756 282459009109 Pfam match to entry PF04055 Radical_SAM, Radical SAM superfamily, score 52.1, E-value 1.3e-12 282459009110 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 282459009111 Pfam match to entry PF03061 4HBT, Thioesterase superfamily, score 89.3, E-value 8.2e-24 282459009112 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 282459009113 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 282459009114 Pfam match to entry PF02073 Peptidase_M29, Thermophilic metalloprotease (M29), score 555.0, E-value 5.3e-164 282459009115 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 282459009116 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 282459009117 Low molecular weight phosphatase family; Region: LMWPc; cd00115 282459009118 active site 282459009119 Pfam match to entry PF01451 LMWPc, Low molecular weight phosphotyrosine protein phosphatase, score 134.3, E-value 2.2e-37 282459009120 Signal peptide predicted for SAS1804 by SignalP 2.0 HMM (Signal peptide probabilty 0.792) with cleavage site probability 0.460 between residues 22 and 23; signal peptide 282459009121 1 probable transmembrane helix predicted for SAS1804 by TMHMM2.0 at aa 5-22 282459009122 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 282459009123 Pfam match to entry PF03631 Ribonuclease_BN, Ribonuclease BN-like family, score 356.1, E-value 3.9e-104 282459009124 6 probable transmembrane helices predicted for SAS1805 by TMHMM2.0 at aa 93-115, 155-177, 190-212, 232-254, 267-289 and 299-321 282459009125 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 282459009126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459009127 active site 282459009128 phosphorylation site [posttranslational modification] 282459009129 intermolecular recognition site; other site 282459009130 dimerization interface [polypeptide binding]; other site 282459009131 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 282459009132 DNA binding residues [nucleotide binding] 282459009133 dimerization interface [polypeptide binding]; other site 282459009134 Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family, score 84.3, E-value 2.6e-22 282459009135 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 130.9, E-value 2.5e-36 282459009136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 282459009137 Signal peptide predicted for SAS1807 by SignalP 2.0 HMM (Signal peptide probabilty 0.924) with cleavage site probability 0.885 between residues 30 and 31; signal peptide 282459009138 Histidine kinase; Region: HisKA_3; pfam07730 282459009139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459009140 ATP binding site [chemical binding]; other site 282459009141 Mg2+ binding site [ion binding]; other site 282459009142 G-X-G motif; other site 282459009143 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 71.6, E-value 1.7e-18 282459009144 2 probable transmembrane helices predicted for SAS1807 by TMHMM2.0 at aa 13-35 and 45-67 282459009145 Predicted membrane protein [Function unknown]; Region: COG4758 282459009146 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 282459009147 4 probable transmembrane helices predicted for SAS1808 by TMHMM2.0 at aa 5-27, 31-49, 56-73 and 77-94 282459009148 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 282459009149 active site 282459009150 Pfam match to entry PF00557 Peptidase_M24, metallopeptidase family M24, score 194.6, E-value 1.6e-55 282459009151 Predicted membrane protein [Function unknown]; Region: COG4129 282459009152 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 282459009153 Pfam match to entry PF06081 DUF939, Bacterial protein of unknown function (DUF939), score 81.8, E-value 3.5e-23 282459009154 4 probable transmembrane helices predicted for SAS1811 by TMHMM2.0 at aa 18-40, 61-79, 89-111 and 123-145 282459009155 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 282459009156 catalytic triad [active] 282459009157 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 282459009158 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 282459009159 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 282459009160 Pfam match to entry PF01225 Mur_ligase, Mur ligase family, catalytic domain, score 22.7, E-value 1.3e-06 282459009161 Pfam match to entry PF01225 Mur_ligase, Mur ligase family, catalytic domain, score 19.2, E-value 1.4e-05 282459009162 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 282459009163 Ferritin-like domain; Region: Ferritin; pfam00210 282459009164 ferroxidase diiron center [ion binding]; other site 282459009165 Pfam match to entry PF00210 ferritin, Ferritin-like domain, score 167.6, E-value 2.2e-47 282459009166 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 282459009167 active site 282459009168 catalytic site [active] 282459009169 substrate binding site [chemical binding]; other site 282459009170 Pfam match to entry PF00929 Exonuclease, Exonuclease, score 99.4, E-value 7.3e-27 282459009171 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 282459009172 active site 282459009173 DNA polymerase IV; Validated; Region: PRK02406 282459009174 DNA binding site [nucleotide binding] 282459009175 Pfam match to entry PF00817 IMS, impB/mucB/samB family, score 387.2, E-value 1.8e-113 282459009176 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 282459009177 4 probable transmembrane helices predicted for SAS1818 by TMHMM2.0 at aa 15-37, 50-72, 104-126 and 131-153 282459009178 TRAM domain; Region: TRAM; cl01282 282459009179 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 282459009180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459009181 S-adenosylmethionine binding site [chemical binding]; other site 282459009182 Pfam match to entry PF05958 tRNA_U5-meth_tr, tRNA (Uracil-5-)-methyltransferase, score -102.8, E-value 1.2e-07 282459009183 PS01231 RNA methyltransferase trmA family signature 2. 282459009184 PS01230 RNA methyltransferase trmA family signature 1. 282459009185 putative lipid kinase; Reviewed; Region: PRK13337 282459009186 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 282459009187 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 282459009188 Pfam match to entry PF00781 DAGKc, Diacylglycerol kinase catalytic domain (presumed), score 84.3, E-value 2.6e-22 282459009189 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 282459009190 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 282459009191 GatB domain; Region: GatB_Yqey; pfam02637 282459009192 Pfam match to entry PF02637 GatB_Yqey, GatB/Yqey domain, score 240.1, E-value 3.2e-69 282459009193 Pfam match to entry PF01162 GatB, PET112 family, C terminal region, score 140.9, E-value 2.4e-39 282459009194 Pfam match to entry PF02934 GatB_N, PET112 family, N terminal region, score 531.3, E-value 6.9e-157 282459009195 PS01234 PET112 family signature. 282459009196 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 282459009197 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 282459009198 Pfam match to entry PF01425 Amidase, Amidase, score 684.2, E-value 6.5e-203 282459009199 PS00571 Amidases signature. 282459009200 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 282459009201 Pfam match to entry PF02686 Glu-tRNAGln, Glu-tRNAGln amidotransferase C subunit, score 80.2, E-value 4.5e-21 282459009202 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 282459009203 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 282459009204 Na binding site [ion binding]; other site 282459009205 13 probable transmembrane helices predicted for SAS1825 by TMHMM2.0 at aa 15-37, 49-71, 86-105, 137-159, 174-196, 203-225, 245-267, 288-310, 320-342, 382-400, 410-432, 439-458 and 468-487 282459009206 Pfam match to entry PF00474 SSF, Sodium:solute symporter family, score 399.0, E-value 5e-117 282459009207 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 282459009208 Signal peptide predicted for SAS1826 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.505 between residues 26 and 27; signal peptide 282459009209 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 282459009210 putative dimer interface [polypeptide binding]; other site 282459009211 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 282459009212 putative dimer interface [polypeptide binding]; other site 282459009213 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459009214 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 282459009215 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 282459009216 nucleotide binding pocket [chemical binding]; other site 282459009217 K-X-D-G motif; other site 282459009218 catalytic site [active] 282459009219 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 282459009220 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 282459009221 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 282459009222 Dimer interface [polypeptide binding]; other site 282459009223 Pfam match to entry PF00533 BRCT, BRCA1 C Terminus (BRCT) domain, score 54.4, E-value 2.7e-13 282459009224 Pfam match to entry PF03119 DNA_ligase_ZBD, NAD-dependent DNA ligase C4 zinc finger domain, score 59.1, E-value 1e-14 282459009225 Pfam match to entry PF03120 DNA_ligase_OB, NAD-dependent DNA ligase OB-fold domain, score 169.3, E-value 6.5e-48 282459009226 PS01056 NAD-dependent DNA ligase signature 2. 282459009227 Pfam match to entry PF01653 DNA_ligase_N, NAD-dependent DNA ligase adenylation domain, score 636.1, E-value 2.1e-188 282459009228 PS01055 NAD-dependent DNA ligase signature 1. 282459009229 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 282459009230 Part of AAA domain; Region: AAA_19; pfam13245 282459009231 Family description; Region: UvrD_C_2; pfam13538 282459009232 Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase, score 839.2, E-value 1.4e-249 282459009233 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009234 PcrB family; Region: PcrB; pfam01884 282459009235 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 282459009236 substrate binding site [chemical binding]; other site 282459009237 putative active site [active] 282459009238 dimer interface [polypeptide binding]; other site 282459009239 Pfam match to entry PF01884 PcrB, PcrB family, score 502.9, E-value 2.5e-148 282459009240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 282459009241 Predicted helix-turn-helix motif for SAS1830 with score 1037.000, SD 2.72 at aa 57-78, sequence YTYATIEQESGASTATISRVKR 282459009242 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 282459009243 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 282459009244 tetramer interface [polypeptide binding]; other site 282459009245 active site 282459009246 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 282459009247 Pfam match to entry PF00206 lyase_1, Lyase, score 335.3, E-value 7e-98 282459009248 PS00163 Fumarate lyases signature. 282459009249 Signal peptide predicted for SAS1832 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.786 between residues 25 and 26; signal peptide 282459009250 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 282459009251 Pfam match to entry PF05543 Peptidase_C47, Staphopain peptidase C47, score 477.1, E-value 1.5e-140 282459009252 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 282459009253 Staphostatin A; Region: Staphostatin_A; pfam09022 282459009254 NETI protein; Region: NETI; pfam14044 282459009255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 282459009256 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 282459009257 3 probable transmembrane helices predicted for SAS1835 by TMHMM2.0 at aa 10-32, 39-61 and 66-83 282459009258 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 282459009259 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 282459009260 homodimer interface [polypeptide binding]; other site 282459009261 NAD binding pocket [chemical binding]; other site 282459009262 ATP binding pocket [chemical binding]; other site 282459009263 Mg binding site [ion binding]; other site 282459009264 active-site loop [active] 282459009265 Pfam match to entry PF02540 NAD_synthase, NAD synthase, score 184.7, E-value 1.5e-52 282459009266 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 282459009267 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 282459009268 active site 282459009269 Pfam match to entry PF04095 NAPRTase, Nicotinate phosphoribosyltransferase (NAPRTase) family, score 126.6, E-value 4.8e-35 282459009270 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 282459009271 active site 282459009272 dimer interface [polypeptide binding]; other site 282459009273 Pfam match to entry PF02898 NO_synthase, Nitric oxide synthase, oxygenase domain, score 380.4, E-value 1.9e-111 282459009274 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 282459009275 Prephenate dehydratase; Region: PDT; pfam00800 282459009276 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 282459009277 putative L-Phe binding site [chemical binding]; other site 282459009278 Pfam match to entry PF00800 PDT, Prephenate dehydratase, score 106.7, E-value 4.6e-29 282459009279 Pfam match to entry PF01842 ACT, ACT domain, score 33.6, E-value 4.8e-07 282459009280 Signal peptide predicted for SAS1840 by SignalP 2.0 HMM (Signal peptide probabilty 0.799) with cleavage site probability 0.733 between residues 64 and 65; signal peptide 282459009281 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 282459009282 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 282459009283 transmembrane helices; other site 282459009284 Pfam match to entry PF00939 Na_sulph_symp, Sodium:sulfate symporter transmembrane region, score 260.7, E-value 2.1e-75 282459009285 14 probable transmembrane helices predicted for SAS1840 by TMHMM2.0 at aa 28-50, 57-74, 78-97, 110-127, 158-180, 205-227, 242-264, 299-318, 323-345, 365-387, 397-419, 426-448, 452-474 and 487-509 282459009286 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 282459009287 PS00435 Peroxidases proximal heme-ligand signature. 282459009288 Isochorismatase family; Region: Isochorismatase; pfam00857 282459009289 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 282459009290 catalytic triad [active] 282459009291 conserved cis-peptide bond; other site 282459009292 Pfam match to entry PF00857 Isochorismatase, Isochorismatase family, score 26.2, E-value 1.1e-09 282459009293 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 282459009294 DHH family; Region: DHH; pfam01368 282459009295 DHHA2 domain; Region: DHHA2; pfam02833 282459009296 Pfam match to entry PF01368 DHH, DHH family, score 60.0, E-value 5.4e-15 282459009297 Pfam match to entry PF02833 DHHA2, DHHA2 domain, score 144.3, E-value 2.3e-40 282459009298 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 282459009299 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 282459009300 NAD(P) binding site [chemical binding]; other site 282459009301 catalytic residues [active] 282459009302 Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family, score 505.6, E-value 4e-149 282459009303 PS00687 Aldehyde dehydrogenases glutamic acid active site. 282459009304 PS00070 Aldehyde dehydrogenases cysteine active site. 282459009305 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 282459009306 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 282459009307 YolD-like protein; Region: YolD; pfam08863 282459009308 Probable gene remnant. Similar to the N-terminal regions of Staphylococcus aureus prophage phiPV83 transposase SWALL:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 2.1e-26, 98.57% id in 70 aa, and Staphylococcus haemolyticus hypothetical 32.7 kDa protein SWALL:Q54270 (EMBL:U35635) (273 aa) fasta scores: E(): 4.3e-24, 90% id in 70 aa. CDS contains a frameshift after codon 10;transposase (fragment) 282459009309 Signal peptide predicted for SAS1848 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.623 between residues 31 and 32; signal peptide 282459009310 1 probable transmembrane helix predicted for SAS1848 by TMHMM2.0 at aa 12-34 282459009311 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 282459009312 active site 282459009313 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 282459009314 Signal peptide predicted for SAS1850 by SignalP 2.0 HMM (Signal peptide probabilty 0.961) with cleavage site probability 0.426 between residues 18 and 19; signal peptide 282459009315 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 282459009316 1 probable transmembrane helix predicted for SAS1850 by TMHMM2.0 at aa 4-26 282459009317 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 282459009318 3 probable transmembrane helices predicted for SAS1851 by TMHMM2.0 at aa 81-103, 107-129 and 136-158 282459009319 Bacterial PH domain; Region: DUF304; cl01348 282459009320 1 probable transmembrane helix predicted for SAS1852 by TMHMM2.0 at aa 21-40 282459009321 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 282459009322 Signal peptide predicted for SAS1854 by SignalP 2.0 HMM (Signal peptide probabilty 0.799) with cleavage site probability 0.494 between residues 41 and 42; signal peptide 282459009323 6 probable transmembrane helices predicted for SAS1854 by TMHMM2.0 at aa 21-38, 48-70, 102-124, 139-161, 166-188 and 219-241 282459009324 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 282459009325 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 282459009326 Walker A/P-loop; other site 282459009327 ATP binding site [chemical binding]; other site 282459009328 Q-loop/lid; other site 282459009329 ABC transporter signature motif; other site 282459009330 Walker B; other site 282459009331 D-loop; other site 282459009332 H-loop/switch region; other site 282459009333 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 147.1, E-value 3.3e-41 282459009334 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009335 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 282459009336 6 probable transmembrane helices predicted for SAS1856 by TMHMM2.0 at aa 13-32, 37-55, 87-109, 119-141, 153-175 and 188-210 282459009337 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 282459009338 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 282459009339 Walker A/P-loop; other site 282459009340 ATP binding site [chemical binding]; other site 282459009341 Q-loop/lid; other site 282459009342 ABC transporter signature motif; other site 282459009343 Walker B; other site 282459009344 D-loop; other site 282459009345 H-loop/switch region; other site 282459009346 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 144.5, E-value 1.9e-40 282459009347 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009348 Predicted transcriptional regulators [Transcription]; Region: COG1725 282459009349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 282459009350 DNA-binding site [nucleotide binding]; DNA binding site 282459009351 Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 64.0, E-value 3.3e-16 282459009352 Signal peptide predicted for SAS1859 by SignalP 2.0 HMM (Signal peptide probabilty 0.600) with cleavage site probability 0.353 between residues 28 and 29; signal peptide 282459009353 3 probable transmembrane helices predicted for SAS1859 by TMHMM2.0 at aa 7-24, 34-51 and 5-24 282459009354 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 282459009355 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 282459009356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459009357 homodimer interface [polypeptide binding]; other site 282459009358 catalytic residue [active] 282459009359 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class I and II, score 39.0, E-value 9.3e-11 282459009360 Ortholog of S. aureus MRSA252 (BX571856) SAR2030; Similar to Staphylococcus aureus mammalian extracellulr protein-binding protein, major histocompatibility complex (MHC) class II analog SWALL:Q53599 (EMBL:U20503) (689 aa) fasta scores: E(): 7.3e-173, 77.79% id in 689 aa. CDS contains a frameshift after codon 578. Frameshift occurs at a poly A nonamer;MHC class II analog (pseudogene) 282459009361 Pfam match to entry PF03642 MAP, MAP domain, score 168.3, E-value 1.4e-47 282459009362 Pfam match to entry PF03642 MAP, MAP domain, score 198.1, E-value 1.4e-56 282459009363 Pfam match to entry PF03642 MAP, MAP domain, score 198.1, E-value 1.4e-56 282459009364 Pfam match to entry PF03642 MAP, MAP domain, score 165.8, E-value 7.7e-47 282459009365 Pfam match to entry PF03642 MAP, MAP domain, score 195.1, E-value 1.1e-55 282459009366 Pfam match to entry PF03642 MAP, MAP domain, score 174.8, E-value 1.5e-49 282459009367 Signal peptide predicted for SAS1861 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.981 between residues 30 and 31 282459009368 Ortholog of S. aureus MRSA252 (BX571856) SAR2031; Identical to Staphylococcus aureus phospholipase C precursor Hlb or Plc SWALL:PHLC_STAAU (SWALL:P09978) (330 aa) fasta scores: E(): 1.3e-123, 100% id in 330 aa. CDS is disrupted by the insertion of phage phiSa3(476) after codon 62;phospholipase C precursor (pseudogene) 282459009369 Signal peptide predicted for SAS1862 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.970 between residues 34 and 35 282459009370 Prophage 282459009371 Signal peptide predicted for SAS1863a by SignalP 2.0 HMM (Signal peptide probabilty 0.920) with cleavage site probability 0.797 between residues 52 and 53; signal peptide 282459009372 1 probable transmembrane helix predicted for SAS1863a by TMHMM2.0 at aa 29-51 282459009373 3 probable transmembrane helices predicted for SAS1864 by TMHMM2.0 at aa 7-29, 33-55 and 62-84 282459009374 2 probable transmembrane helices predicted for SAS1865 by TMHMM2.0 at aa 12-34 and 39-61 282459009375 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 282459009376 Signal peptide predicted for SAS1866 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.656 between residues 31 and 32; signal peptide 282459009377 Similar to the C-terminal region of Staphylococcus aureus temperate phage phiSLT amidase SWALL:Q9B0C3 (EMBL:AB045978) (484 aa) fasta scores: E(): 9.4e-34, 90.81% id in 98 aa;amidase (fragment) 282459009378 Signal peptide predicted for SAS1868 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.983 between residues 27 and 28; signal peptide 282459009379 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 282459009380 Pfam match to entry PF02821 Staphylokinase, Staphylokinase/Streptokinase family, score 141.3, E-value 1.8e-39 282459009381 CHAP domain; Region: CHAP; pfam05257 282459009382 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009383 Pfam match to entry PF05257 CHAP, CHAP domain, score 124.2, E-value 2.6e-34 282459009384 Small integral membrane protein [Function unknown]; Region: COG5546 282459009385 Signal peptide predicted for SAS1870 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.986 between residues 31 and 32; signal peptide 282459009386 Pfam match to entry PF04531 Phage_holin_1, Bacteriophage holin, score 198.7, E-value 9.5e-57 282459009387 1 probable transmembrane helix predicted for SAS1870 by TMHMM2.0 at aa 12-34 282459009388 1 probable transmembrane helix predicted for SAS1871 by TMHMM2.0 at aa 30-52 282459009389 Signal peptide predicted for SAS1872 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.476 between residues 24 and 25; signal peptide 282459009390 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 282459009391 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459009392 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 238.8, E-value 7.8e-69 282459009393 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459009394 PS00277 Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin signature 1. 282459009395 Pfam match to entry PF01123 Stap_Strp_toxin, Staphylococcal/Streptococcal toxin, OB-fold domain, score 162.7, E-value 6.5e-46 282459009396 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 282459009397 Ligand-gated ion channel; Region: Lig_chan; pfam00060 282459009398 1 probable transmembrane helix predicted for SAS1873 by TMHMM2.0 at aa 98-120 282459009399 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 282459009400 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 282459009401 TolA protein; Region: tolA_full; TIGR02794 282459009402 Phage tail protein; Region: Sipho_tail; cl17486 282459009403 Phage tail protein; Region: Sipho_tail; cl17486 282459009404 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 282459009405 Phage-related protein [Function unknown]; Region: COG5412 282459009406 Peptidase family M23; Region: Peptidase_M23; pfam01551 282459009407 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 282459009408 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 282459009409 N-acetyl-D-glucosamine binding site [chemical binding]; other site 282459009410 catalytic residue [active] 282459009411 Pfam match to entry PF01464 SLT, Transglycosylase SLT domain, score 17.3, E-value 7.2e-05 282459009412 Pfam match to entry PF01551 Peptidase_M37, Peptidase family M23/M37, score 99.3, E-value 7.8e-27 282459009413 Pfam match to entry PF05017 TMP, TMP repeat, score 11.1, E-value 2.9 282459009414 Pfam match to entry PF05017 TMP, TMP repeat, score 8.6, E-value 8.1 282459009415 Pfam match to entry PF05017 TMP, TMP repeat, score 8.1, E-value 9.7 282459009416 Pfam match to entry PF05017 TMP, TMP repeat, score 7.5, E-value 12 282459009417 Pfam match to entry PF05017 TMP, TMP repeat, score 8.3, E-value 9 282459009418 Pfam match to entry PF05017 TMP, TMP repeat, score 4.8, E-value 31 282459009419 Pfam match to entry PF05017 TMP, TMP repeat, score 5.6, E-value 23 282459009420 6 probable transmembrane helices predicted for SAS1878 by TMHMM2.0 at aa 499-521, 534-556, 566-588, 705-727, 742-764 and 783-805 282459009421 Pfam match to entry PF05017 TMP, TMP repeat, score 2.5, E-value 70 282459009422 Pfam match to entry PF05017 TMP, TMP repeat, score 4.8, E-value 31 282459009423 Pfam match to entry PF05017 TMP, TMP repeat, score 12.2, E-value 1.3 282459009424 Pfam match to entry PF05017 TMP, TMP repeat, score 1.7, E-value 95 282459009425 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 282459009426 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 282459009427 Pfam match to entry PF02368 Big_2, Bacterial Ig-like domain (group 2), score 69.4, E-value 8.2e-18 282459009428 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 282459009429 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 282459009430 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 282459009431 oligomerization interface [polypeptide binding]; other site 282459009432 Pfam match to entry PF05135 Phage_QLRG, Phage QLRG family, DNA packaging, score 188.5, E-value 1.1e-53 282459009433 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 282459009434 Phage capsid family; Region: Phage_capsid; pfam05065 282459009435 Pfam match to entry PF05065 Phage_capsid, Phage Capsid Family, score 754.9, E-value 3.4e-224 282459009436 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 282459009437 Pfam match to entry PF04586 Caudo_protease, Caudovirus prohead protease, score 345.5, E-value 6e-101 282459009438 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 282459009439 Phage-related protein [Function unknown]; Region: COG4695; cl01923 282459009440 Pfam match to entry PF04860 Phage_portal, Phage portal protein, score 392.6, E-value 4.1e-115 282459009441 Signal peptide predicted for SAS1890 by SignalP 2.0 HMM (Signal peptide probabilty 0.768) with cleavage site probability 0.660 between residues 38 and 39; signal peptide 282459009442 2 probable transmembrane helices predicted for SAS1890 by TMHMM2.0 at aa 7-29 and 39-58 282459009443 Phage Terminase; Region: Terminase_1; pfam03354 282459009444 Pfam match to entry PF03354 Terminase_1, Phage Terminase, score 993.2, E-value 6.6e-296 282459009445 Phage terminase, small subunit; Region: Terminase_4; pfam05119 282459009446 Pfam match to entry PF05119 Terminase_4, Phage terminase, small subunit, score 141.0, E-value 2.2e-39 282459009447 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 282459009448 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 282459009449 active site 282459009450 Pfam match to entry PF01844 HNH, HNH endonuclease, score 44.8, E-value 2.1e-10 282459009451 PS00190 Cytochrome c family heme-binding site signature. 282459009452 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 282459009453 putative metal binding site [ion binding]; other site 282459009454 Signal peptide predicted for SAS1896 by SignalP 2.0 HMM (Signal peptide probabilty 0.931) with cleavage site probability 0.350 between residues 25 and 26; signal peptide 282459009455 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 282459009456 1 probable transmembrane helix predicted for SAS1896 by TMHMM2.0 at aa 4-22 282459009457 1 probable transmembrane helix predicted for SAS1898 by TMHMM2.0 at aa 12-34 282459009458 Transcriptional activator RinB; Region: RinB; pfam06116 282459009459 Pfam match to entry PF06116 RinB, Transcriptional activator RinB, score 122.2, E-value 1e-33 282459009460 Probable gene remnant. Similar to C-terminal region of Bacteriophage phi ETA orf35 SWALL:Q9G010 (EMBL:AP001553) (68 aa) fasta scores: E(): 4.3e-08, 83.87% id in 31 aa;hypothetical phage protein (fragment) 282459009461 Probable gene remnant. Similar to the N-terminal regions of Staphylococcus aureus bacteriophage PVL orf 50 SWALL:O80088 (EMBL:AB009866) (122 aa) fasta scores: E(): 1.9e-27, 89.58% id in 96 aa, and Staphylococcus aureus prophage phiPV83 phi PVL orf 50 SWALL:Q9MBR4 (EMBL:AB044554) (123 aa) fasta scores: E(): 2e-24, 80.2% id in 96 aa;hypothetical phage protein (fragment) 282459009462 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 282459009463 Pfam match to entry PF05866 RusA, Endodeoxyribonuclease RusA, score 172.4, E-value 7.9e-49 282459009464 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 282459009465 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 282459009466 Pfam match to entry PF04271 DnaD, DnaD-like domain, score 118.1, E-value 1.7e-32 282459009467 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 282459009468 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 282459009469 dimer interface [polypeptide binding]; other site 282459009470 ssDNA binding site [nucleotide binding]; other site 282459009471 tetramer (dimer of dimers) interface [polypeptide binding]; other site 282459009472 Pfam match to entry PF00436 SSB, Single-strand binding protein family, score 143.8, E-value 3.2e-40 282459009473 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 282459009474 RecT family; Region: RecT; pfam03837 282459009475 Pfam match to entry PF03837 RecT, RecT family, score 272.8, E-value 4.8e-79 282459009476 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 282459009477 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009478 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 282459009479 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 282459009480 Signal peptide predicted for SAS1910 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.719 between residues 38 and 39; signal peptide 282459009481 1 probable transmembrane helix predicted for SAS1910 by TMHMM2.0 at aa 7-29 282459009482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 282459009483 Pfam match to entry PF05595 DUF771, Domain of unknown function (DUF771), score 223.6, E-value 3.1e-64 282459009484 Ortholog of S. aureus MRSA252 (BX571856) SAR2096; Almost identical to Staphylococcus aureus phage phi 13 anti-repressor SWALL:Q8SDM9 (EMBL:AF424783) (249 aa) fasta scores: E(): 5.9e-90, 99.19% id in 249 aa, and to Staphylococcus aureus bacteriophage PVL anti repressor SWALL:O80074 (EMBL:AB009866) (249 aa) fasta scores: E(): 9e-90, 98.79% id in 249 aa. CDS contains a frameshift after codon 130;anti-repressor (pseudogene) 282459009485 Pfam match to entry PF03374 ANT, Phage antirepressor protein, score 330.8, E-value 1.6e-96 282459009486 1 probable transmembrane helix predicted for SAS1916 by TMHMM2.0 at aa 4-22 282459009487 Protein of unknown function (DUF739); Region: DUF739; pfam05339 282459009488 Pfam match to entry PF05339 DUF739, Protein of unknown function (DUF739), score 123.2, E-value 5.2e-34 282459009489 Predicted helix-turn-helix motif for SAS1918 with score 1238.000, SD 3.40 at aa 17-38, sequence GTQYNFAIAMKLSERSLSLKLN 282459009490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282459009491 non-specific DNA binding site [nucleotide binding]; other site 282459009492 salt bridge; other site 282459009493 sequence-specific DNA binding site [nucleotide binding]; other site 282459009494 Predicted transcriptional regulator [Transcription]; Region: COG2932 282459009495 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 282459009496 Catalytic site [active] 282459009497 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 34.9, E-value 2e-07 282459009498 Signal peptide predicted for SAS1920 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.856 between residues 26 and 27; signal peptide 282459009499 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 282459009500 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459009501 1 probable transmembrane helix predicted for SAS1920 by TMHMM2.0 at aa 7-29 282459009502 Pfam match to entry PF01123 Stap_Strp_toxin, Staphylococcal/Streptococcal toxin, OB-fold domain, score 86.1, E-value 7.3e-23 282459009503 PS00277 Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin signature 1. 282459009504 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 114.1, E-value 2.8e-31 282459009505 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459009506 Signal peptide predicted for SAS1921 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.920 between residues 23 and 24; signal peptide 282459009507 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 282459009508 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 282459009509 Pfam match to entry PF01123 Stap_Strp_toxin, Staphylococcal/Streptococcal toxin, OB-fold domain, score 105.8, E-value 8.7e-29 282459009510 Pfam match to entry PF02876 Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain, score 93.7, E-value 3.9e-25 282459009511 PS00278 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. 282459009512 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 282459009513 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 282459009514 Int/Topo IB signature motif; other site 282459009515 Pfam match to entry PF00589 Phage_integrase, Phage integrase family, score 64.1, E-value 3.2e-16 282459009516 Pfam match to entry PF03372 Exo_endo_phos, Endonuclease/Exonuclease/phosphatase family, score 100.7, E-value 2.9e-27 282459009517 Signal peptide predicted for SAS1924 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 29 and 30; signal peptide 282459009518 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 282459009519 Pfam match to entry PF01117 Aerolysin, Aerolysin/Hemolysin/Leukocidin toxin, score 335.3, E-value 7e-98 282459009520 PS00340 Growth factor and cytokines receptors family signature 2. 282459009521 Signal peptide predicted for SAS1925 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.385 between residues 29 and 30; signal peptide 282459009522 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 282459009523 Pfam match to entry PF01117 Aerolysin, Aerolysin/Hemolysin/Leukocidin toxin, score 275.6, E-value 6.7e-80 282459009524 1 probable transmembrane helix predicted for SAS1925 by TMHMM2.0 at aa 7-24 282459009525 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 282459009526 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 282459009527 metal binding site [ion binding]; metal-binding site 282459009528 dimer interface [polypeptide binding]; other site 282459009529 Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40, score 287.4, E-value 1.9e-83 282459009530 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 282459009531 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 282459009532 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 282459009533 Signal peptide predicted for SAS1928 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.365 between residues 28 and 29; signal peptide 282459009534 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 282459009535 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 282459009536 putative ligand binding residues [chemical binding]; other site 282459009537 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 109.0, E-value 9.9e-30 282459009538 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459009539 Signal peptide predicted for SAS1929 by SignalP 2.0 HMM (Signal peptide probabilty 0.917) with cleavage site probability 0.389 between residues 33 and 34; signal peptide 282459009540 Cation transport protein; Region: TrkH; cl17365 282459009541 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 282459009542 11 probable transmembrane helices predicted for SAS1929 by TMHMM2.0 at aa 7-29, 71-93, 123-145, 155-177, 184-206, 221-240, 270-292, 297-319, 339-361, 365-384 and 397-419 282459009543 Pfam match to entry PF02386 TrkH, Cation transport protein, score 255.3, E-value 8.4e-74 282459009544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459009545 Coenzyme A binding pocket [chemical binding]; other site 282459009546 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 42.6, E-value 9.3e-10 282459009547 4 probable transmembrane helices predicted for SAS1931 by TMHMM2.0 at aa 12-34, 60-82, 109-131 and 135-157 282459009548 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 282459009549 Pfam match to entry PF03592 Terminase_2, Terminase small subunit, score 250.1, E-value 3.2e-72 282459009550 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 282459009551 Probable gene remnant. Similar to the C-terminal regions of Streptococcus pyogenes integrase-like protein SWALL:Q938N9 (EMBL:AY050245) (365 aa) fasta scores: E(): 1.3e-12, 34.32% id in 169 aa, and Enterococcus faecalis site-specific recombinase, phage integrase family ef2855 SWALL:Q830D2 (EMBL:AE016955) (393 aa) fasta scores: E(): 9.5e-12, 33.14% id in 178 aa. CDS contains a frameshift after codon 115; integrase (fragment) 282459009552 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 282459009553 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 282459009554 ring oligomerisation interface [polypeptide binding]; other site 282459009555 ATP/Mg binding site [chemical binding]; other site 282459009556 stacking interactions; other site 282459009557 hinge regions; other site 282459009558 Pfam match to entry PF00118 cpn60_TCP1, TCP-1/cpn60 chaperonin family, score 658.8, E-value 2.9e-195 282459009559 PS00296 Chaperonins cpn60 signature. 282459009560 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 282459009561 oligomerisation interface [polypeptide binding]; other site 282459009562 mobile loop; other site 282459009563 roof hairpin; other site 282459009564 Pfam match to entry PF00166 cpn10, Chaperonin 10 Kd subunit, score 196.0, E-value 6.2e-56 282459009565 PS00681 Chaperonins cpn10 signature. 282459009566 CAAX protease self-immunity; Region: Abi; pfam02517 282459009567 6 probable transmembrane helices predicted for SAS1937 by TMHMM2.0 at aa 5-25, 40-62, 82-104, 119-141, 162-180 and 185-202 282459009568 Pfam match to entry PF02517 Abi, CAAX amino terminal protease family, score 86.4, E-value 5.9e-23 282459009569 Signal peptide predicted for SAS1938 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.967 between residues 32 and 33; signal peptide 282459009570 1 probable transmembrane helix predicted for SAS1938 by TMHMM2.0 at aa 347-366 282459009571 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 282459009572 dimer interface [polypeptide binding]; other site 282459009573 FMN binding site [chemical binding]; other site 282459009574 Predicted amidohydrolase [General function prediction only]; Region: COG0388 282459009575 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 282459009576 putative active site [active] 282459009577 catalytic triad [active] 282459009578 putative dimer interface [polypeptide binding]; other site 282459009579 Pfam match to entry PF00795 CN_hydrolase, Carbon-nitrogen hydrolase, score 157.5, E-value 2.3e-44 282459009580 PS01227 Uncharacterized protein family UPF0012 signature. 282459009581 delta-hemolysin; Provisional; Region: PRK14752 282459009582 Pfam match to entry PF05372 Delta_lysin, Delta lysin family, score 57.3, E-value 3.5e-14 282459009583 Accessory gene regulator B; Region: AgrB; smart00793 282459009584 Pfam match to entry PF04647 AgrB, Accessory gene regulator B, score 435.6, E-value 4.5e-128 282459009585 5 probable transmembrane helices predicted for SAS1941 by TMHMM2.0 at aa 47-69, 82-104, 108-125, 142-159 and 164-183 282459009586 Staphylococcal AgrD protein; Region: AgrD; smart00794 282459009587 Pfam match to entry PF05931 AgrD, Staphylococcal AgrD protein, score 81.1, E-value 2.4e-21 282459009588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459009589 Mg2+ binding site [ion binding]; other site 282459009590 G-X-G motif; other site 282459009591 6 probable transmembrane helices predicted for SAS1943 by TMHMM2.0 at aa 7-29, 49-71, 78-100, 110-132, 145-167 and 182-204 282459009592 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 16.6, E-value 0.0014 282459009593 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 282459009594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459009595 active site 282459009596 phosphorylation site [posttranslational modification] 282459009597 intermolecular recognition site; other site 282459009598 dimerization interface [polypeptide binding]; other site 282459009599 LytTr DNA-binding domain; Region: LytTR; pfam04397 282459009600 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 104.0, E-value 3e-28 282459009601 Pfam match to entry PF04397 LytTR, LytTr DNA-binding domain, score 110.9, E-value 2.6e-30 282459009602 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 282459009603 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 282459009604 putative substrate binding site [chemical binding]; other site 282459009605 putative ATP binding site [chemical binding]; other site 282459009606 Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 351.6, E-value 8.7e-103 282459009607 PS00584 pfkB family of carbohydrate kinases signature 2. 282459009608 PS00583 pfkB family of carbohydrate kinases signature 1. 282459009609 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 282459009610 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 282459009611 substrate binding [chemical binding]; other site 282459009612 active site 282459009613 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 282459009614 Pfam match to entry PF00251 Glyco_hydro_32, Glycosyl hydrolases family 32, score 651.5, E-value 4.8e-193 282459009615 PS00609 Glycosyl hydrolases family 32 active site. 282459009616 Transcriptional regulators [Transcription]; Region: PurR; COG1609 282459009617 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 282459009618 DNA binding site [nucleotide binding] 282459009619 domain linker motif; other site 282459009620 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 282459009621 dimerization interface [polypeptide binding]; other site 282459009622 ligand binding site [chemical binding]; other site 282459009623 Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family, score -25.7, E-value 0.005 282459009624 Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, score 40.7, E-value 3.6e-09 282459009625 Predicted helix-turn-helix motif for SAS1947 with score 2286.000, SD 6.97 at aa 2-23, sequence KNISDIAKLAGVSKSTVSRFLN 282459009626 PS00356 Bacterial regulatory proteins, lacI family signature. 282459009627 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 282459009628 Signal peptide predicted for SAS1948 by SignalP 2.0 HMM (Signal peptide probabilty 0.856) with cleavage site probability 0.505 between residues 33 and 34; signal peptide 282459009629 Pfam match to entry PF00909 Ammonium_transp, Ammonium Transporter Family, score 478.5, E-value 5.7e-141 282459009630 11 probable transmembrane helices predicted for SAS1948 by TMHMM2.0 at aa 6-28, 48-70, 95-117, 124-146, 156-178, 190-212, 222-244, 253-272, 276-298, 310-329 and 349-371 282459009631 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 282459009632 CPxP motif; other site 282459009633 Pfam match to entry PF01206 UPF0033, Uncharacterized protein family UPF0033, score 94.7, E-value 1.9e-25 282459009634 Predicted transporter component [General function prediction only]; Region: COG2391 282459009635 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 282459009636 Sulphur transport; Region: Sulf_transp; pfam04143 282459009637 Pfam match to entry PF04143 DUF395, YeeE/YedE family (DUF395), score 91.6, E-value 1.6e-24 282459009638 9 probable transmembrane helices predicted for SAS1950 by TMHMM2.0 at aa 4-18, 39-61, 71-93, 105-127, 147-169, 199-218, 248-267, 288-310 and 320-339 282459009639 Pfam match to entry PF04143 DUF395, YeeE/YedE family (DUF395), score 61.4, E-value 2e-15 282459009640 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 282459009641 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 282459009642 CoA binding domain; Region: CoA_binding; pfam02629 282459009643 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 282459009644 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282459009645 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282459009646 ABC transporter; Region: ABC_tran_2; pfam12848 282459009647 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 282459009648 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 159.2, E-value 7.3e-45 282459009649 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009650 PS00211 ABC transporters family signature. 282459009651 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 148.4, E-value 1.3e-41 282459009652 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009653 PS00211 ABC transporters family signature. 282459009654 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 282459009655 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 282459009656 Walker A/P-loop; other site 282459009657 ATP binding site [chemical binding]; other site 282459009658 Q-loop/lid; other site 282459009659 ABC transporter signature motif; other site 282459009660 Walker B; other site 282459009661 D-loop; other site 282459009662 H-loop/switch region; other site 282459009663 2 probable transmembrane helices predicted for SAS1953 by TMHMM2.0 at aa 5-27 and 159-181 282459009664 Pfam match to entry PF02866 ldh_C, lactate/malate dehydrogenase, alpha/beta C-terminal domain, score 12.0, E-value 0.0047 282459009665 Pfam match to entry PF00488 MutS_V, MutS domain V, score -20.3, E-value 1.1e-12 282459009666 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009667 UGMP family protein; Validated; Region: PRK09604 282459009668 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 282459009669 Pfam match to entry PF00814 Peptidase_M22, Glycoprotease family, score 392.7, E-value 3.8e-115 282459009670 PS01016 Glycoprotease family signature. 282459009671 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 282459009672 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459009673 Coenzyme A binding pocket [chemical binding]; other site 282459009674 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 69.3, E-value 8.8e-18 282459009675 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 282459009676 Glycoprotease family; Region: Peptidase_M22; pfam00814 282459009677 Pfam match to entry PF00814 Peptidase_M22, Glycoprotease family, score 110.0, E-value 4.6e-30 282459009678 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 282459009679 Pfam match to entry PF02367 UPF0079, Uncharacterised P-loop hydrolase UPF0079, score 147.7, E-value 2.1e-41 282459009680 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009681 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 282459009682 6-phosphogluconate dehydratase; Region: edd; TIGR01196 282459009683 Pfam match to entry PF00920 ILVD_EDD, Dehydratase family, score 1139.1, E-value 0 282459009684 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 282459009685 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 282459009686 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 282459009687 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 282459009688 PYR/PP interface [polypeptide binding]; other site 282459009689 dimer interface [polypeptide binding]; other site 282459009690 TPP binding site [chemical binding]; other site 282459009691 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 282459009692 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 282459009693 TPP-binding site [chemical binding]; other site 282459009694 dimer interface [polypeptide binding]; other site 282459009695 Pfam match to entry PF02776 TPP_enzymes_N, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 300.4, E-value 2.3e-87 282459009696 Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzyme, central domain, score 185.8, E-value 7.2e-53 282459009697 Pfam match to entry PF02775 TPP_enzymes_C, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 301.3, E-value 1.3e-87 282459009698 PS00187 Thiamine pyrophosphate enzymes signature. 282459009699 Ortholog of S. aureus MRSA252 (BX571856) SAR2142; Probable gene remnant. Similar to the N-terminal region of Bacillus subtilis acetolactate synthase small subunit IlvH or IlvN or BSU28300 SWALL:ILVH_BACSU (SWALL:P37252) (174 aa) fasta scores: E(): 1.3e-05, 37.83% id in 74 aa;acetolactate synthase isozyme III small subunit (fragment) 282459009700 Pfam match to entry PF01842 ACT, ACT domain, score 34.9, E-value 1.9e-07 282459009701 ketol-acid reductoisomerase; Provisional; Region: PRK05479 282459009702 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 282459009703 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 282459009704 Pfam match to entry PF01450 IlvC, Acetohydroxy acid isomeroreductase, catalytic domain, score 277.7, E-value 1.6e-80 282459009705 2-isopropylmalate synthase; Validated; Region: PRK00915 282459009706 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 282459009707 active site 282459009708 catalytic residues [active] 282459009709 metal binding site [ion binding]; metal-binding site 282459009710 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 282459009711 Pfam match to entry PF00682 HMGL-like, HMGL-like, score 394.4, E-value 1.1e-115 282459009712 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 282459009713 tartrate dehydrogenase; Region: TTC; TIGR02089 282459009714 Pfam match to entry PF00180 isodh, Isocitrate/isopropylmalate dehydrogenase, score 594.2, E-value 8.3e-176 282459009715 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 282459009716 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 282459009717 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 282459009718 substrate binding site [chemical binding]; other site 282459009719 ligand binding site [chemical binding]; other site 282459009720 Pfam match to entry PF00330 aconitase, Aconitase family (aconitate hydratase), score 757.8, E-value 4.6e-225 282459009721 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009722 PS00450 Aconitase family signature 1. 282459009723 PS01244 Aconitase family signature 2. 282459009724 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 282459009725 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 282459009726 substrate binding site [chemical binding]; other site 282459009727 Pfam match to entry PF00694 Aconitase_C, Aconitase C-terminal domain, score 196.3, E-value 5.1e-56 282459009728 threonine dehydratase; Validated; Region: PRK08639 282459009729 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 282459009730 tetramer interface [polypeptide binding]; other site 282459009731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459009732 catalytic residue [active] 282459009733 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 282459009734 putative Ile/Val binding site [chemical binding]; other site 282459009735 Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme, score 298.6, E-value 7.8e-87 282459009736 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 282459009737 Pfam match to entry PF00585 Thr_dehydrat_C, C-terminal regulatory domain of Threonine dehydratase, score 88.7, E-value 1.2e-23 282459009738 hypothetical protein; Provisional; Region: PRK04351 282459009739 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 282459009740 Pfam match to entry PF03926 DUF335, metallopeptidase (SprT family), score 148.2, E-value 1.5e-41 282459009741 PS00190 Cytochrome c family heme-binding site signature. 282459009742 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 282459009743 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 282459009744 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 282459009745 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 282459009746 RNA binding site [nucleotide binding]; other site 282459009747 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 73.8, E-value 3.8e-19 282459009748 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 282459009749 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 282459009750 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 282459009751 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 282459009752 DNA binding residues [nucleotide binding] 282459009753 Pfam match to entry PF04545 sigma70_r4, Sigma-70, region 4, score 63.0, E-value 6.7e-16 282459009754 Predicted helix-turn-helix motif for SAS1969 with score 1939.000, SD 5.79 at aa 223-244, sequence LSQKETGERIGLSQMHVSRLQR 282459009755 Pfam match to entry PF04539 sigma70_r3, Sigma-70 region 3, score 85.2, E-value 1.3e-22 282459009756 Pfam match to entry PF04542 sigma70_r2, Sigma-70 region 2, score 74.9, E-value 1.7e-19 282459009757 PS00715 Sigma-70 factors family signature 1. 282459009758 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 282459009759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459009760 ATP binding site [chemical binding]; other site 282459009761 Mg2+ binding site [ion binding]; other site 282459009762 G-X-G motif; other site 282459009763 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 31.0, E-value 3e-06 282459009764 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 282459009765 anti sigma factor interaction site; other site 282459009766 regulatory phosphorylation site [posttranslational modification]; other site 282459009767 Pfam match to entry PF01740 STAS, STAS domain, score 90.9, E-value 2.7e-24 282459009768 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 282459009769 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 282459009770 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 282459009771 PemK-like protein; Region: PemK; pfam02452 282459009772 Pfam match to entry PF02452 PemK, PemK-like protein, score 200.9, E-value 2.1e-57 282459009773 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 282459009774 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 282459009775 active site 282459009776 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 282459009777 dimer interface [polypeptide binding]; other site 282459009778 substrate binding site [chemical binding]; other site 282459009779 catalytic residues [active] 282459009780 Pfam match to entry PF00842 Ala_racemase_C, Alanine racemase, C-terminal domain, score 240.2, E-value 3.1e-69 282459009781 Pfam match to entry PF01168 Ala_racemase_N, Alanine racemase, N-terminal domain, score 324.3, E-value 1.5e-94 282459009782 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 282459009783 Pfam match to entry PF01648 ACPS, 4'-phosphopantetheinyl transferase superfamily, score 90.7, E-value 3.1e-24 282459009784 Uncharacterized conserved protein [Function unknown]; Region: COG3402 282459009785 Pfam match to entry PF03703 DUF304, Bacterial membrane flanked domain, score 84.5, E-value 2.2e-22 282459009786 2 probable transmembrane helices predicted for SAS1977 by TMHMM2.0 at aa 20-42 and 52-74 282459009787 Predicted membrane protein [Function unknown]; Region: COG3428 282459009788 Bacterial PH domain; Region: DUF304; pfam03703 282459009789 Bacterial PH domain; Region: DUF304; pfam03703 282459009790 6 probable transmembrane helices predicted for SAS1978 by TMHMM2.0 at aa 13-35, 45-67, 210-232, 252-274, 389-411 and 415-437 282459009791 Pfam match to entry PF03703 DUF304, Bacterial membrane flanked domain, score 85.3, E-value 1.3e-22 282459009792 Pfam match to entry PF03703 DUF304, Bacterial membrane flanked domain, score 84.8, E-value 1.8e-22 282459009793 Bacterial PH domain; Region: DUF304; cl01348 282459009794 2 probable transmembrane helices predicted for SAS1979 by TMHMM2.0 at aa 16-38 and 48-70 282459009795 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 282459009796 Signal peptide predicted for SAS1980 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.418 between residues 35 and 36; signal peptide 282459009797 Pfam match to entry PF02669 KdpC, K+-transporting ATPase, c chain, score 178.2, E-value 1.4e-50 282459009798 1 probable transmembrane helix predicted for SAS1980 by TMHMM2.0 at aa 7-29 282459009799 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 282459009800 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 282459009801 Soluble P-type ATPase [General function prediction only]; Region: COG4087 282459009802 7 probable transmembrane helices predicted for SAS1981 by TMHMM2.0 at aa 33-55, 59-81, 217-239, 249-271, 569-591, 611-630 and 650-672 282459009803 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 105.5, E-value 1e-28 282459009804 PS00154 E1-E2 ATPases phosphorylation site. 282459009805 Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 ATPase, score 180.2, E-value 3.6e-51 282459009806 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 282459009807 Pfam match to entry PF03814 KdpA, Potassium-transporting ATPase A subunit, score 1282.9, E-value 0 282459009808 12 probable transmembrane helices predicted for SAS1982 by TMHMM2.0 at aa 4-26, 63-85, 127-149, 169-191, 245-267, 280-302, 325-347, 354-372, 376-398, 415-437, 484-506 and 526-548 282459009809 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 282459009810 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 282459009811 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 282459009812 Ligand Binding Site [chemical binding]; other site 282459009813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282459009814 dimer interface [polypeptide binding]; other site 282459009815 phosphorylation site [posttranslational modification] 282459009816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459009817 ATP binding site [chemical binding]; other site 282459009818 Mg2+ binding site [ion binding]; other site 282459009819 G-X-G motif; other site 282459009820 Pfam match to entry PF02702 KdpD, Osmosensitive K+ channel His kinase sensor domain, score 472.7, E-value 3.1e-139 282459009821 4 probable transmembrane helices predicted for SAS1983 by TMHMM2.0 at aa 383-405, 412-430, 434-453 and 466-484 282459009822 Pfam match to entry PF00512 HisKA, His Kinase A (phosphoacceptor) domain, score 48.7, E-value 1.4e-11 282459009823 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 99.3, E-value 8e-27 282459009824 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282459009825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459009826 active site 282459009827 phosphorylation site [posttranslational modification] 282459009828 intermolecular recognition site; other site 282459009829 dimerization interface [polypeptide binding]; other site 282459009830 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282459009831 DNA binding site [nucleotide binding] 282459009832 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 100.8, E-value 2.9e-27 282459009833 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 71.3, E-value 2.2e-18 282459009834 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 282459009835 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 282459009836 ATP binding site [chemical binding]; other site 282459009837 Mg++ binding site [ion binding]; other site 282459009838 motif III; other site 282459009839 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282459009840 nucleotide binding region [chemical binding]; other site 282459009841 ATP-binding site [chemical binding]; other site 282459009842 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 125.9, E-value 7.7e-35 282459009843 Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase, score 258.5, E-value 9.5e-75 282459009844 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 282459009845 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009846 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 282459009847 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 282459009848 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 282459009849 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 282459009850 Pfam match to entry PF02875 Mur_ligase_C, Mur ligase family, glutamate ligase domain, score 57.8, E-value 2.4e-14 282459009851 Pfam match to entry PF01225 Mur_ligase, Mur ligase family, catalytic domain, score 161.2, E-value 1.9e-45 282459009852 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 282459009853 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 282459009854 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 282459009855 Pfam match to entry PF01820 Dala_Dala_ligas, D-ala D-ala ligase, score 523.4, E-value 1.7e-154 282459009856 PS00843 D-alanine--D-alanine ligase signature 1. 282459009857 Signal peptide predicted for SAS1988 by SignalP 2.0 HMM (Signal peptide probabilty 0.808) with cleavage site probability 0.330 between residues 43 and 44; signal peptide 282459009858 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 282459009859 Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein, score 361.4, E-value 1e-105 282459009860 10 probable transmembrane helices predicted for SAS1988 by TMHMM2.0 at aa 19-41, 51-70, 77-96, 111-133, 153-172, 176-195, 202-224, 296-318, 330-352 and 362-384 282459009861 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 282459009862 Pfam match to entry PF00403 HMA, Heavy-metal-associated domain, score 15.7, E-value 0.023 282459009863 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 282459009864 putative homodimer interface [polypeptide binding]; other site 282459009865 putative homotetramer interface [polypeptide binding]; other site 282459009866 allosteric switch controlling residues; other site 282459009867 putative metal binding site [ion binding]; other site 282459009868 putative homodimer-homodimer interface [polypeptide binding]; other site 282459009869 Pfam match to entry PF02583 DUF156, Uncharacterised BCR, COG1937, score 72.6, E-value 8.7e-19 282459009870 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 282459009871 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 282459009872 putative active site [active] 282459009873 catalytic site [active] 282459009874 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 282459009875 putative active site [active] 282459009876 catalytic site [active] 282459009877 2 probable transmembrane helices predicted for SAS1992 by TMHMM2.0 at aa 13-35 and 45-67 282459009878 Pfam match to entry PF00614 PLDc, Phospholipase D. Active site motif, score 40.3, E-value 4.6e-09 282459009879 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009880 PS00136 Serine proteases, subtilase family, aspartic acid active site. 282459009881 Pfam match to entry PF00614 PLDc, Phospholipase D. Active site motif, score 39.8, E-value 6.2e-09 282459009882 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 282459009883 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 282459009884 Zn2+ binding site [ion binding]; other site 282459009885 Mg2+ binding site [ion binding]; other site 282459009886 Pfam match to entry PF01966 HD, HD domain, score 31.8, E-value 1.7e-06 282459009887 Signal peptide predicted for SAS1994 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.637 between residues 23 and 24; signal peptide 282459009888 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 282459009889 Pfam match to entry PF02096 60KD_IMP, 60Kd inner membrane protein, score 170.5, E-value 3e-48 282459009890 6 probable transmembrane helices predicted for SAS1994 by TMHMM2.0 at aa 5-22, 57-79, 131-153, 173-195, 207-224 and 229-251 282459009891 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 282459009892 thiamine phosphate binding site [chemical binding]; other site 282459009893 active site 282459009894 pyrophosphate binding site [ion binding]; other site 282459009895 Pfam match to entry PF02581 TMP-TENI, Thiamine monophosphate synthase/TENI, score 242.3, E-value 7e-70 282459009896 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 282459009897 substrate binding site [chemical binding]; other site 282459009898 multimerization interface [polypeptide binding]; other site 282459009899 ATP binding site [chemical binding]; other site 282459009900 Pfam match to entry PF02110 HK, Hydroxyethylthiazole kinase family, score 302.5, E-value 5.5e-88 282459009901 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 282459009902 dimer interface [polypeptide binding]; other site 282459009903 substrate binding site [chemical binding]; other site 282459009904 ATP binding site [chemical binding]; other site 282459009905 Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 15.1, E-value 0.00035 282459009906 thiaminase II; Region: salvage_TenA; TIGR04306 282459009907 Pfam match to entry PF03070 TENA_THI-4, TENA/THI-4 family, score 190.3, E-value 3.3e-54 282459009908 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 282459009909 Signal peptide predicted for SAS1999 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.825 between residues 27 and 28; signal peptide 282459009910 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 282459009911 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 282459009912 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 282459009913 dimer interface [polypeptide binding]; other site 282459009914 ssDNA binding site [nucleotide binding]; other site 282459009915 tetramer (dimer of dimers) interface [polypeptide binding]; other site 282459009916 Pfam match to entry PF00436 SSB, Single-strand binding protein family, score 106.6, E-value 5e-29 282459009917 YwpF-like protein; Region: YwpF; pfam14183 282459009918 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 282459009919 Pfam match to entry PF03061 4HBT, Thioesterase superfamily, score 88.3, E-value 1.6e-23 282459009920 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 282459009921 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 282459009922 hinge; other site 282459009923 active site 282459009924 Pfam match to entry PF00275 EPSP_synthase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase), score 503.9, E-value 1.3e-148 282459009925 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009926 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009927 Predicted membrane protein [Function unknown]; Region: COG4836 282459009928 2 probable transmembrane helices predicted for SAS2004 by TMHMM2.0 at aa 7-26 and 41-63 282459009929 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 282459009930 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 282459009931 gamma subunit interface [polypeptide binding]; other site 282459009932 epsilon subunit interface [polypeptide binding]; other site 282459009933 LBP interface [polypeptide binding]; other site 282459009934 Pfam match to entry PF00401 ATP-synt_DE, ATP synthase, Delta/Epsilon chain, long alpha-helix domain, score 37.5, E-value 3.2e-08 282459009935 Pfam match to entry PF02823 ATP-synt_DE_N, ATP synthase, Delta/Epsilon chain, beta-sandwich domain, score 106.6, E-value 5e-29 282459009936 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 282459009937 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 282459009938 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 282459009939 alpha subunit interaction interface [polypeptide binding]; other site 282459009940 Walker A motif; other site 282459009941 ATP binding site [chemical binding]; other site 282459009942 Walker B motif; other site 282459009943 inhibitor binding site; inhibition site 282459009944 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 282459009945 Pfam match to entry PF00306 ATP-synt_ab_C, ATP synthase alpha/beta chain, C terminal domain, score 181.3, E-value 1.6e-51 282459009946 Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain, score 301.3, E-value 1.2e-87 282459009947 PS00152 ATP synthase alpha and beta subunits signature. 282459009948 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009949 Pfam match to entry PF02874 ATP-synt_ab_N, ATP synthase alpha/beta family, beta-barrel domain, score 94.2, E-value 2.7e-25 282459009950 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 282459009951 core domain interface [polypeptide binding]; other site 282459009952 delta subunit interface [polypeptide binding]; other site 282459009953 epsilon subunit interface [polypeptide binding]; other site 282459009954 Pfam match to entry PF00231 ATP-synt, ATP synthase, score 419.6, E-value 3e-123 282459009955 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 282459009956 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 282459009957 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 282459009958 beta subunit interaction interface [polypeptide binding]; other site 282459009959 Walker A motif; other site 282459009960 ATP binding site [chemical binding]; other site 282459009961 Walker B motif; other site 282459009962 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 282459009963 Pfam match to entry PF00306 ATP-synt_ab_C, ATP synthase alpha/beta chain, C terminal domain, score 119.6, E-value 6.2e-33 282459009964 Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain, score 361.1, E-value 1.2e-105 282459009965 PS00152 ATP synthase alpha and beta subunits signature. 282459009966 PS00017 ATP/GTP-binding site motif A (P-loop). 282459009967 Pfam match to entry PF02874 ATP-synt_ab_N, ATP synthase alpha/beta family, beta-barrel domain, score 83.5, E-value 4.5e-22 282459009968 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 282459009969 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 282459009970 Pfam match to entry PF00213 OSCP, ATP synthase delta (OSCP) subunit, score 122.4, E-value 9.1e-34 282459009971 PS00389 ATP synthase delta (OSCP) subunit signature. 282459009972 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 282459009973 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 282459009974 Pfam match to entry PF00430 ATP-synt_B, ATP synthase B/B' CF(0), score 141.4, E-value 1.6e-39 282459009975 1 probable transmembrane helix predicted for SAS2010 by TMHMM2.0 at aa 7-29 282459009976 Signal peptide predicted for SAS2011 by SignalP 2.0 HMM (Signal peptide probabilty 0.889) with cleavage site probability 0.521 between residues 27 and 28; signal peptide 282459009977 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 282459009978 Pfam match to entry PF00137 ATP-synt_C, ATP synthase subunit C, score 106.6, E-value 5.1e-29 282459009979 2 probable transmembrane helices predicted for SAS2011 by TMHMM2.0 at aa 4-26 and 47-69 282459009980 PS00605 ATP synthase c subunit signature. 282459009981 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 282459009982 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 282459009983 Pfam match to entry PF00119 ATP-synt_A, ATP synthase A chain, score 200.1, E-value 3.6e-57 282459009984 5 probable transmembrane helices predicted for SAS2012 by TMHMM2.0 at aa 15-37, 81-103, 118-137, 171-193 and 208-230 282459009985 PS00449 ATP synthase a subunit signature. 282459009986 Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468 282459009987 4 probable transmembrane helices predicted for SAS2013 by TMHMM2.0 at aa 12-29, 34-56, 69-86 and 91-113 282459009988 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 282459009989 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 282459009990 active site 282459009991 homodimer interface [polypeptide binding]; other site 282459009992 Pfam match to entry PF02350 Epimerase_2, UDP-N-acetylglucosamine 2-epimerase, score 597.8, E-value 6.8e-177 282459009993 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 282459009994 active site 282459009995 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain, score 37.4, E-value 3.3e-08 282459009996 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 282459009997 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 282459009998 dimer interface [polypeptide binding]; other site 282459009999 active site 282459010000 glycine-pyridoxal phosphate binding site [chemical binding]; other site 282459010001 folate binding site [chemical binding]; other site 282459010002 Pfam match to entry PF00464 SHMT, Serine hydroxymethyltransferase, score 889.7, E-value 9e-265 282459010003 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 282459010004 hypothetical protein; Provisional; Region: PRK13690 282459010005 Pfam match to entry PF04260 DUF436, Protein of unknown function (DUF436), score 443.3, E-value 2.2e-130 282459010006 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 282459010007 Low molecular weight phosphatase family; Region: LMWPc; cd00115 282459010008 active site 282459010009 Pfam match to entry PF01451 LMWPc, Low molecular weight phosphotyrosine protein phosphatase, score 74.7, E-value 2e-19 282459010010 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 282459010011 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 282459010012 Pfam match to entry PF03481 SUA5, SUA5 domain, score 209.1, E-value 6.8e-60 282459010013 Pfam match to entry PF01300 Sua5_yciO_yrdC, yrdC domain, score 209.4, E-value 5.5e-60 282459010014 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 282459010015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459010016 S-adenosylmethionine binding site [chemical binding]; other site 282459010017 PS00092 N-6 Adenine-specific DNA methylases signature. 282459010018 peptide chain release factor 1; Validated; Region: prfA; PRK00591 282459010019 This domain is found in peptide chain release factors; Region: PCRF; smart00937 282459010020 RF-1 domain; Region: RF-1; pfam00472 282459010021 Pfam match to entry PF00472 RF-1, Peptidyl-tRNA hydrolase domain, score 240.3, E-value 2.9e-69 282459010022 PS00745 Prokaryotic-type class I peptide chain release factors signature. 282459010023 Pfam match to entry PF03462 PCRF, PCRF domain, score 236.1, E-value 5.1e-68 282459010024 thymidine kinase; Provisional; Region: PRK04296 282459010025 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00014 Endoplasmic reticulum targeting sequence. 282459010026 Pfam match to entry PF00265 TK, Thymidine kinase, score 281.6, E-value 1e-81 282459010027 PS00603 Thymidine kinase cellular-type signature. 282459010028 PS00017 ATP/GTP-binding site motif A (P-loop). 282459010029 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 282459010030 Pfam match to entry PF01197 Ribosomal_L31, Ribosomal protein L31, score 77.9, E-value 2.2e-20 282459010031 PS01143 Ribosomal protein L31 signature. 282459010032 transcription termination factor Rho; Provisional; Region: rho; PRK09376 282459010033 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 282459010034 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 282459010035 RNA binding site [nucleotide binding]; other site 282459010036 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 282459010037 Walker A motif; other site 282459010038 ATP binding site [chemical binding]; other site 282459010039 Walker B motif; other site 282459010040 Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain, score 115.8, E-value 8.9e-32 282459010041 PS00017 ATP/GTP-binding site motif A (P-loop). 282459010042 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 282459010043 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 282459010044 NAD binding site [chemical binding]; other site 282459010045 catalytic residues [active] 282459010046 Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family, score 597.5, E-value 8.6e-177 282459010047 PS00070 Aldehyde dehydrogenases cysteine active site. 282459010048 PS00687 Aldehyde dehydrogenases glutamic acid active site. 282459010049 Predicted transcriptional regulators [Transcription]; Region: COG1733 282459010050 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 282459010051 Pfam match to entry PF01638 DUF24, Transcriptional regulator, score 35.8, E-value 1.4e-08 282459010052 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 282459010053 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 282459010054 hinge; other site 282459010055 active site 282459010056 Pfam match to entry PF00275 EPSP_synthase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase), score 366.2, E-value 3.6e-107 282459010057 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 282459010058 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 282459010059 intersubunit interface [polypeptide binding]; other site 282459010060 active site 282459010061 zinc binding site [ion binding]; other site 282459010062 Na+ binding site [ion binding]; other site 282459010063 Pfam match to entry PF01116 F_bP_aldolase, Fructose-bisphosphate aldolase class-II, score 514.7, E-value 7.3e-152 282459010064 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 282459010065 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 282459010066 CTP synthetase; Validated; Region: pyrG; PRK05380 282459010067 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 282459010068 Catalytic site [active] 282459010069 active site 282459010070 UTP binding site [chemical binding]; other site 282459010071 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 282459010072 active site 282459010073 putative oxyanion hole; other site 282459010074 catalytic triad [active] 282459010075 Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I, score 248.1, E-value 1.3e-71 282459010076 PS00442 Glutamine amidotransferases class-I active site. 282459010077 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 282459010078 Pfam match to entry PF05066 RNA_pol_delta, DNA-directed RNA polymerase delta subunit, score 64.9, E-value 1.8e-16 282459010079 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 282459010080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459010081 Coenzyme A binding pocket [chemical binding]; other site 282459010082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 282459010083 Coenzyme A binding pocket [chemical binding]; other site 282459010084 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 53.0, E-value 6.7e-13 282459010085 pantothenate kinase; Provisional; Region: PRK13317 282459010086 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 282459010087 Pfam match to entry PF03630 Fumble, Fumble, score 422.6, E-value 3.8e-124 282459010088 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 282459010089 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 282459010090 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 282459010091 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 282459010092 metal binding site [ion binding]; metal-binding site 282459010093 Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40, score 63.6, E-value 4.4e-16 282459010094 S-ribosylhomocysteinase; Provisional; Region: PRK02260 282459010095 Pfam match to entry PF02664 LuxS, LuxS protein, score 290.2, E-value 2.7e-84 282459010096 Predicted membrane protein [Function unknown]; Region: COG4270 282459010097 3 probable transmembrane helices predicted for SAS2038 by TMHMM2.0 at aa 4-21, 40-57 and 67-84 282459010098 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 282459010099 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 282459010100 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 282459010101 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 282459010102 Pfam match to entry PF00591 Glycos_transf_3, Glycosyl transferase family, a/b domain, score 237.7, E-value 1.7e-68 282459010103 PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. 282459010104 Pfam match to entry PF02885 Glycos_trans_3N, Glycosyl transferase family, helical bundle domain, score 90.2, E-value 4.2e-24 282459010105 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 282459010106 intersubunit interface [polypeptide binding]; other site 282459010107 active site 282459010108 catalytic residue [active] 282459010109 Pfam match to entry PF01791 DeoC, Deoxyribose-phosphate aldolase, score 348.9, E-value 5.8e-102 282459010110 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 282459010111 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 282459010112 Pfam match to entry PF01048 PNP_UDP_1, Phosphorylase family, score 330.3, E-value 2.3e-96 282459010113 PS01232 Purine and other phosphorylases family 1 signature. 282459010114 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 282459010115 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 282459010116 dimerization interface [polypeptide binding]; other site 282459010117 DPS ferroxidase diiron center [ion binding]; other site 282459010118 ion pore; other site 282459010119 Pfam match to entry PF00210 ferritin, Ferritin-like domain, score 97.1, E-value 3.5e-26 282459010120 PS00818 Dps protein family signature 1. 282459010121 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 282459010122 Pfam match to entry PF04134 DUF393, Protein of unknown function, DUF393, score 26.4, E-value 4e-07 282459010123 EVE domain; Region: EVE; cl00728 282459010124 Signal peptide predicted for SAS2045 by SignalP 2.0 HMM (Signal peptide probabilty 0.810) with cleavage site probability 0.215 between residues 36 and 37; signal peptide 282459010125 3 probable transmembrane helices predicted for SAS2045 by TMHMM2.0 at aa 5-24, 29-47 and 52-74 282459010126 PS00443 Glutamine amidotransferases class-II active site. 282459010127 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 282459010128 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 282459010129 Pfam match to entry PF01238 PMI_typeI, Phosphomannose isomerase type I, score 67.2, E-value 3.6e-17 282459010130 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 282459010131 NADH(P)-binding; Region: NAD_binding_10; pfam13460 282459010132 NAD(P) binding site [chemical binding]; other site 282459010133 putative active site [active] 282459010134 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 282459010135 dimerization interface [polypeptide binding]; other site 282459010136 putative DNA binding site [nucleotide binding]; other site 282459010137 putative Zn2+ binding site [ion binding]; other site 282459010138 Pfam match to entry PF01022 HTH_5, Bacterial regulatory protein, arsR family, score 76.9, E-value 4.3e-20 282459010139 Predicted helix-turn-helix motif for SAS2048 with score 1380.000, SD 3.89 at aa 40-61, sequence ASVGHISHQLNLSQSNVSHQLK 282459010140 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 282459010141 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 282459010142 6 probable transmembrane helices predicted for SAS2049 by TMHMM2.0 at aa 22-44, 54-73, 90-112, 127-145, 158-180 and 185-207 282459010143 Pfam match to entry PF01545 Cation_efflux, Cation efflux family, score 393.7, E-value 1.9e-115 282459010144 Signal peptide predicted for SAS2050 by SignalP 2.0 HMM (Signal peptide probabilty 0.761) with cleavage site probability 0.199 between residues 28 and 29; signal peptide 282459010145 6 probable transmembrane helices predicted for SAS2050 by TMHMM2.0 at aa 20-42, 66-88, 118-140, 173-195, 230-252 and 267-289 282459010146 similar to hypothetical protein; Ortholog of S. aureus MRSA252 (BX571856) SAR2237; Doubtful CDS. No database matches 282459010147 1 probable transmembrane helix predicted for SAS2051 by TMHMM2.0 at aa 4-21 282459010148 Ortholog of S. aureus MRSA252 (BX571856) SAR2238; Similar to an internal region of Bacillus thuringiensis transposase for insertion sequence element IS232 SWALL:T232_BACTB (SWALL:Q99335) (431 aa) fasta scores: E(): 3e-26, 45.19% id in 177 aa;transposase (fragment) 282459010149 1 probable transmembrane helix predicted for SAS2052 by TMHMM2.0 at aa 104-121 282459010150 Syndecan domain; Region: Syndecan; pfam01034 282459010151 1 probable transmembrane helix predicted for SAS2052a by TMHMM2.0 at aa 4-21 282459010152 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 282459010153 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459010154 active site 282459010155 motif I; other site 282459010156 motif II; other site 282459010157 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459010158 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 24.8, E-value 0.00022 282459010159 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 282459010160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282459010161 Walker A/P-loop; other site 282459010162 ATP binding site [chemical binding]; other site 282459010163 Q-loop/lid; other site 282459010164 ABC transporter signature motif; other site 282459010165 Walker B; other site 282459010166 D-loop; other site 282459010167 H-loop/switch region; other site 282459010168 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 146.7, E-value 4.4e-41 282459010169 PS00017 ATP/GTP-binding site motif A (P-loop). 282459010170 PS00017 ATP/GTP-binding site motif A (P-loop). 282459010171 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 282459010172 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 282459010173 glutaminase active site [active] 282459010174 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 282459010175 dimer interface [polypeptide binding]; other site 282459010176 active site 282459010177 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 282459010178 dimer interface [polypeptide binding]; other site 282459010179 active site 282459010180 Pfam match to entry PF01380 SIS, SIS domain, score 76.1, E-value 7.7e-20 282459010181 Pfam match to entry PF01380 SIS, SIS domain, score 141.8, E-value 1.3e-39 282459010182 Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II, score 197.5, E-value 2.2e-56 282459010183 PS00443 Glutamine amidotransferases class-II active site. 282459010184 1 probable transmembrane helix predicted for SAS2056 by TMHMM2.0 at aa 33-50 282459010185 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 282459010186 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 282459010187 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 282459010188 active site 282459010189 P-loop; other site 282459010190 phosphorylation site [posttranslational modification] 282459010191 9 probable transmembrane helices predicted for SAS2057 by TMHMM2.0 at aa 21-43, 53-72, 93-115, 135-157, 164-186, 219-241, 248-270, 275-297 and 318-340 282459010192 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 76.2, E-value 7.2e-20 282459010193 Pfam match to entry PF02302 PTS_IIB, PTS system, Lactose/Cellobiose specific IIB subunit, score 78.7, E-value 1.3e-20 282459010194 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 282459010195 HTH domain; Region: HTH_11; pfam08279 282459010196 Mga helix-turn-helix domain; Region: Mga; pfam05043 282459010197 PRD domain; Region: PRD; pfam00874 282459010198 PRD domain; Region: PRD; pfam00874 282459010199 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 282459010200 active site 282459010201 P-loop; other site 282459010202 phosphorylation site [posttranslational modification] 282459010203 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 282459010204 active site 282459010205 phosphorylation site [posttranslational modification] 282459010206 Predicted helix-turn-helix motif for SAS2058 with score 1504.000, SD 4.31 at aa 22-43, sequence ITIHDIAQQLAVSSRTIHRELK 282459010207 Predicted helix-turn-helix motif for SAS2058 with score 1415.000, SD 4.01 at aa 108-129, sequence VKQYSLAQEIGVSVQTLAKMLD 282459010208 Pfam match to entry PF00874 PRD, PRD domain, score 87.0, E-value 4.1e-23 282459010209 Pfam match to entry PF00874 PRD, PRD domain, score 98.4, E-value 1.4e-26 282459010210 Pfam match to entry PF02302 PTS_IIB, PTS system, Lactose/Cellobiose specific IIB subunit, score 20.3, E-value 4.2e-05 282459010211 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282459010212 active site 282459010213 phosphorylation site [posttranslational modification] 282459010214 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 235.6, E-value 7.4e-68 282459010215 PS00372 PTS EIIA domains phosphorylation site signature 2. 282459010216 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 282459010217 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 282459010218 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 282459010219 Pfam match to entry PF01232 Mannitol_dh, Mannitol dehydrogenase, score 312.1, E-value 6.9e-91 282459010220 PS00974 Mannitol dehydrogenases signature. 282459010221 Ortholog of S. aureus MRSA252 (BX571856) SAR2248; Similar to Staphylococcus aureus cell wall protein essential for optimal methicillin resistance FmtB SWALL:Q9LCH2 (EMBL:AB025716) (2478 aa) fasta scores: E(): 0, 95.89% id in 2508 aa. CDS contains a nonsense mutation (ochre) after codon 1795; surface anchored protein (pseudogene) 282459010222 Pfam match to entry PF01468 GA, GA module, score 9.2, E-value 0.087 282459010223 Signal peptide predicted for SAS2061 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.452 between residues 38 and 39 282459010224 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 40.3, E-value 4.7e-09 282459010225 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 282459010226 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 282459010227 active site 282459010228 substrate binding site [chemical binding]; other site 282459010229 metal binding site [ion binding]; metal-binding site 282459010230 Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase, C-terminal domain, score 32.7, E-value 8.9e-07 282459010231 Pfam match to entry PF02880 PGM_PMM_III, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III, score 95.9, E-value 8.4e-26 282459010232 Pfam match to entry PF02879 PGM_PMM_II, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II, score 92.5, E-value 8.7e-25 282459010233 Pfam match to entry PF02878 PGM_PMM_I, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I, score 204.7, E-value 1.5e-58 282459010234 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 282459010235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 282459010236 Signal peptide predicted for SAS2064 by SignalP 2.0 HMM (Signal peptide probabilty 0.943) with cleavage site probability 0.398 between residues 28 and 29; signal peptide 282459010237 YbbR-like protein; Region: YbbR; pfam07949 282459010238 1 probable transmembrane helix predicted for SAS2064 by TMHMM2.0 at aa 10-32 282459010239 TIGR00159 family protein; Region: TIGR00159 282459010240 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 282459010241 Pfam match to entry PF02457 DUF147, Domain of unknown function DUF147, score 251.2, E-value 1.5e-72 282459010242 2 probable transmembrane helices predicted for SAS2065 by TMHMM2.0 at aa 15-37 and 44-66 282459010243 Arginase family; Region: Arginase; cd09989 282459010244 active site 282459010245 Mn binding site [ion binding]; other site 282459010246 oligomer interface [polypeptide binding]; other site 282459010247 Pfam match to entry PF00491 arginase, Arginase family, score 390.3, E-value 2e-114 282459010248 PS01053 Arginase family signature 3. 282459010249 PS00148 Arginase family signature 2. 282459010250 PS00147 Arginase family signature 1. 282459010251 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 282459010252 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 282459010253 Walker A motif; other site 282459010254 PS00017 ATP/GTP-binding site motif A (P-loop). 282459010255 Signal peptide predicted for SAS2068 by SignalP 2.0 HMM (Signal peptide probabilty 0.972) with cleavage site probability 0.314 between residues 33 and 34; signal peptide 282459010256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459010257 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282459010258 putative substrate translocation pore; other site 282459010259 14 probable transmembrane helices predicted for SAS2068 by TMHMM2.0 at aa 13-35, 50-72, 79-98, 108-130, 137-159, 169-191, 203-220, 224-246, 266-288, 298-320, 332-351, 361-383, 403-425 and 445-467 282459010260 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -114.2, E-value 0.0032 282459010261 Signal peptide predicted for SAS2069 by SignalP 2.0 HMM (Signal peptide probabilty 0.851) with cleavage site probability 0.455 between residues 26 and 27; signal peptide 282459010262 4 probable transmembrane helices predicted for SAS2069 by TMHMM2.0 at aa 15-37, 61-78, 93-115 and 120-139 282459010263 Signal peptide predicted for SAS2070 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.281 between residues 28 and 29; signal peptide 282459010264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459010265 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282459010266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459010267 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -98.0, E-value 0.00096 282459010268 14 probable transmembrane helices predicted for SAS2070 by TMHMM2.0 at aa 7-29, 39-61, 68-87, 97-119, 131-153, 157-179, 199-214, 218-237, 257-279, 289-311, 323-342, 346-363, 384-406 and 416-438 282459010269 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 282459010270 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 282459010271 7 probable transmembrane helices predicted for SAS2071 by TMHMM2.0 at aa 32-54, 58-80, 92-114, 118-140, 153-172, 176-197 and 204-226 282459010272 Pfam match to entry PF03006 UPF0073, Uncharacterised protein family (Hly-III / UPF0073), score 263.4, E-value 3.2e-76 282459010273 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 282459010274 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 282459010275 substrate binding site; other site 282459010276 dimerization interface; other site 282459010277 Pfam match to entry PF01704 UDPGP, UTP--glucose-1-phosphate uridylyltransferase, score 114.3, E-value 2.4e-31 282459010278 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 282459010279 4 probable transmembrane helices predicted for SAS2073 by TMHMM2.0 at aa 20-42, 62-84, 94-116 and 137-159 282459010280 Pfam match to entry PF04307 DUF457, Predicted membrane-bound metal-dependent hydrolase (DUF457), score 137.5, E-value 2.6e-38 282459010281 Signal peptide predicted for SAS2075 by SignalP 2.0 HMM (Signal peptide probabilty 0.960) with cleavage site probability 0.767 between residues 35 and 36; signal peptide 282459010282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 282459010283 Nucleoside recognition; Region: Gate; pfam07670 282459010284 10 probable transmembrane helices predicted for SAS2075 by TMHMM2.0 at aa 9-31, 60-82, 95-117, 132-154, 216-235, 245-267, 330-352, 372-394, 401-423 and 433-455 282459010285 Signal peptide predicted for SAS2076 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.859 between residues 37 and 38; signal peptide 282459010286 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 282459010287 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282459010288 ABC-ATPase subunit interface; other site 282459010289 dimer interface [polypeptide binding]; other site 282459010290 putative PBP binding regions; other site 282459010291 Pfam match to entry PF01032 FecCD, FecCD transport family, score 380.9, E-value 1.3e-111 282459010292 8 probable transmembrane helices predicted for SAS2076 by TMHMM2.0 at aa 13-32, 52-74, 110-132, 142-164, 184-206, 234-256, 269-291 and 301-318 282459010293 Signal peptide predicted for SAS2077 by SignalP 2.0 HMM (Signal peptide probabilty 0.898) with cleavage site probability 0.751 between residues 42 and 43; signal peptide 282459010294 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 282459010295 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 282459010296 ABC-ATPase subunit interface; other site 282459010297 dimer interface [polypeptide binding]; other site 282459010298 putative PBP binding regions; other site 282459010299 8 probable transmembrane helices predicted for SAS2077 by TMHMM2.0 at aa 21-43, 70-92, 105-124, 128-150, 206-228, 248-279, 286-308 and 318-340 282459010300 Pfam match to entry PF01032 FecCD, FecCD transport family, score 411.6, E-value 7.8e-121 282459010301 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 282459010302 Signal peptide predicted for SAS2078 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.414 between residues 30 and 31; signal peptide 282459010303 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 282459010304 siderophore binding site; other site 282459010305 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 198.8, E-value 8.8e-57 282459010306 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459010307 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 282459010308 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 282459010309 dimer interface [polypeptide binding]; other site 282459010310 active site 282459010311 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 282459010312 substrate binding site [chemical binding]; other site 282459010313 catalytic residue [active] 282459010314 Pfam match to entry PF01168 Ala_racemase_N, Alanine racemase, N-terminal domain, score 138.4, E-value 1.3e-38 282459010315 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 282459010316 IucA / IucC family; Region: IucA_IucC; pfam04183 282459010317 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 282459010318 Pfam match to entry PF04183 IucA_IucC, IucA / IucC family, score 580.9, E-value 8.6e-172 282459010319 H+ Antiporter protein; Region: 2A0121; TIGR00900 282459010320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459010321 putative substrate translocation pore; other site 282459010322 11 probable transmembrane helices predicted for SAS2081 by TMHMM2.0 at aa 5-27, 34-56, 76-98, 137-159, 163-185, 213-235, 245-267, 274-292, 296-313, 333-355 and 359-381 282459010323 Pfam match to entry PF05977 DUF894, Bacterial protein of unknown function (DUF894), score 58.3, E-value 3e-16 282459010324 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 282459010325 IucA / IucC family; Region: IucA_IucC; pfam04183 282459010326 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 282459010327 Pfam match to entry PF04183 IucA_IucC, IucA / IucC family, score 619.1, E-value 2.6e-183 282459010328 Asp23 family; Region: Asp23; pfam03780 282459010329 Pfam match to entry PF03780 DUF322, Protein of unknown function (DUF322), score 98.2, E-value 1.7e-26 282459010330 Small integral membrane protein [Function unknown]; Region: COG5547 282459010331 2 probable transmembrane helices predicted for SAS2084 by TMHMM2.0 at aa 22-41 and 45-64 282459010332 Signal peptide predicted for SAS2085 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.627 between residues 29 and 30; signal peptide 282459010333 2 probable transmembrane helices predicted for SAS2085 by TMHMM2.0 at aa 7-26 and 41-63 282459010334 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 282459010335 Signal peptide predicted for SAS2086 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.605 between residues 24 and 25; signal peptide 282459010336 Pfam match to entry PF02028 BCCT, BCCT family transporter, score 780.1, E-value 9.2e-232 282459010337 12 probable transmembrane helices predicted for SAS2086 by TMHMM2.0 at aa 5-27, 42-64, 85-107, 137-159, 188-210, 225-247, 260-282, 313-335, 348-370, 394-416, 437-459 and 463-485 282459010338 PS01303 BCCT family of transporters signature. 282459010339 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 282459010340 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 282459010341 putative NAD(P) binding site [chemical binding]; other site 282459010342 dimer interface [polypeptide binding]; other site 282459010343 Pfam match to entry PF00107 ADH_zinc_N, Zinc-binding dehydrogenase, score 167.8, E-value 1.9e-47 282459010344 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 282459010345 Prostaglandin dehydrogenases; Region: PGDH; cd05288 282459010346 NAD(P) binding site [chemical binding]; other site 282459010347 substrate binding site [chemical binding]; other site 282459010348 dimer interface [polypeptide binding]; other site 282459010349 Pfam match to entry PF00107 ADH_zinc_N, Zinc-binding dehydrogenase, score 123.5, E-value 4e-34 282459010350 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 282459010351 Signal peptide predicted for SAS2089 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.642 between residues 29 and 30; signal peptide 282459010352 Pfam match to entry PF06028 DUF915, Bacterial protein of unknown function (DUF915), score 491.8, E-value 5.7e-145 282459010353 1 probable transmembrane helix predicted for SAS2089 by TMHMM2.0 at aa 4-26 282459010354 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 282459010355 beta-galactosidase; Region: BGL; TIGR03356 282459010356 Pfam match to entry PF00232 Glyco_hydro_1, Glycosyl hydrolase family 1, score 905.9, E-value 1.2e-269 282459010357 PS00572 Glycosyl hydrolases family 1 active site. 282459010358 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 282459010359 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 282459010360 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 282459010361 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 282459010362 active site 282459010363 P-loop; other site 282459010364 phosphorylation site [posttranslational modification] 282459010365 Pfam match to entry PF02302 PTS_IIB, PTS system, Lactose/Cellobiose specific IIB subunit, score 119.0, E-value 9.2e-33 282459010366 10 probable transmembrane helices predicted for SAS2091 by TMHMM2.0 at aa 31-53, 73-91, 104-121, 136-158, 181-198, 218-240, 283-305, 333-355, 362-384 and 389-411 282459010367 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 367.7, E-value 1.3e-107 282459010368 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 282459010369 methionine cluster; other site 282459010370 active site 282459010371 phosphorylation site [posttranslational modification] 282459010372 metal binding site [ion binding]; metal-binding site 282459010373 Pfam match to entry PF02255 PTS_IIA, PTS system, Lactose/Cellobiose specific IIA subunit, score 210.9, E-value 2e-60 282459010374 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 282459010375 Pfam match to entry PF04274 LacD, Tagatose 1,6-diphosphate aldolase, (LacD), score 791.4, E-value 3.6e-235 282459010376 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 282459010377 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 282459010378 putative substrate binding site [chemical binding]; other site 282459010379 putative ATP binding site [chemical binding]; other site 282459010380 Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 215.4, E-value 8.9e-62 282459010381 PS00584 pfkB family of carbohydrate kinases signature 2. 282459010382 PS00583 pfkB family of carbohydrate kinases signature 1. 282459010383 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 282459010384 Pfam match to entry PF02502 LacAB_rpiB, Ribose/Galactose Isomerase, score 164.8, E-value 1.5e-46 282459010385 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 282459010386 Pfam match to entry PF02502 LacAB_rpiB, Ribose/Galactose Isomerase, score 129.5, E-value 6.5e-36 282459010387 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 282459010388 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 282459010389 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 282459010390 Pfam match to entry PF00455 deoR, Bacterial regulatory proteins, deoR family, score 420.9, E-value 1.3e-123 282459010391 PS00894 Bacterial regulatory proteins, deoR family signature. 282459010392 NAD-dependent deacetylase; Provisional; Region: PRK00481 282459010393 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 282459010394 NAD+ binding site [chemical binding]; other site 282459010395 substrate binding site [chemical binding]; other site 282459010396 putative Zn binding site [ion binding]; other site 282459010397 Pfam match to entry PF02146 SIR2, Sir2 family, score 311.3, E-value 1.2e-90 282459010398 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 282459010399 PS00190 Cytochrome c family heme-binding site signature. 282459010400 1 probable transmembrane helix predicted for SAS2099 by TMHMM2.0 at aa 21-43 282459010401 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 282459010402 1 probable transmembrane helix predicted for SAS2100a by TMHMM2.0 at aa 4-26 282459010403 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 282459010404 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 282459010405 active site 282459010406 catalytic tetrad [active] 282459010407 Pfam match to entry PF00248 aldo_ket_red, Aldo/keto reductase family, score 358.3, E-value 8.6e-105 282459010408 PS00063 Aldo/keto reductase family active site signature. 282459010409 PS00062 Aldo/keto reductase family signature 2. 282459010410 PS00798 Aldo/keto reductase family signature 1. 282459010411 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 282459010412 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 282459010413 DNA binding residues [nucleotide binding] 282459010414 putative dimer interface [polypeptide binding]; other site 282459010415 Pfam match to entry PF00376 merR, MerR family regulatory protein, score 38.2, E-value 2e-08 282459010416 Predicted helix-turn-helix motif for SAS2102 with score 1484.000, SD 4.24 at aa 1-22, sequence MKTKEVVALMNISQDTLRYYEK 282459010417 Signal peptide predicted for SAS2103 by SignalP 2.0 HMM (Signal peptide probabilty 0.968) with cleavage site probability 0.673 between residues 30 and 31; signal peptide 282459010418 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 282459010419 substrate binding site [chemical binding]; other site 282459010420 catalytic residues [active] 282459010421 Pfam match to entry PF02278 Lyase_8, Polysaccharide lyase family 8, super-sandwich domain, score 514.4, E-value 8.9e-152 282459010422 Pfam match to entry PF02884 Lyase_8_C, Polysaccharide lyase family 8, C-terminal beta-sandwich domain, score 134.8, E-value 1.6e-37 282459010423 Signal peptide predicted for SAS2104 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.862 between residues 30 and 31; signal peptide 282459010424 MAP domain; Region: MAP; pfam03642 282459010425 Pfam match to entry PF03642 MAP, MAP domain, score 169.0, E-value 8.3e-48 282459010426 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 282459010427 Pfam match to entry PF03306 AAL_decarboxy, Alpha-acetolactate decarboxylase, score 290.0, E-value 3e-84 282459010428 acetolactate synthase; Reviewed; Region: PRK08617 282459010429 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 282459010430 PYR/PP interface [polypeptide binding]; other site 282459010431 dimer interface [polypeptide binding]; other site 282459010432 TPP binding site [chemical binding]; other site 282459010433 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 282459010434 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 282459010435 TPP-binding site [chemical binding]; other site 282459010436 Pfam match to entry PF02775 TPP_enzymes_C, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 242.2, E-value 7.7e-70 282459010437 PS00187 Thiamine pyrophosphate enzymes signature. 282459010438 Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzyme, central domain, score 84.3, E-value 2.5e-22 282459010439 Pfam match to entry PF02776 TPP_enzymes_N, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 212.3, E-value 7.9e-61 282459010440 2 probable transmembrane helices predicted for SAS2107a by TMHMM2.0 at aa 12-30 and 34-56 282459010441 similar to hypothetical protein; Doubtful CDS 282459010442 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 282459010443 Pfam match to entry PF00380 Ribosomal_S9, Ribosomal protein S9/S16, score 202.4, E-value 7.5e-58 282459010444 PS00360 Ribosomal protein S9 signature. 282459010445 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 282459010446 23S rRNA interface [nucleotide binding]; other site 282459010447 L3 interface [polypeptide binding]; other site 282459010448 Pfam match to entry PF00572 Ribosomal_L13, Ribosomal protein L13, score 271.5, E-value 1.1e-78 282459010449 PS00783 Ribosomal protein L13 signature. 282459010450 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 282459010451 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 282459010452 dimerization interface 3.5A [polypeptide binding]; other site 282459010453 active site 282459010454 Pfam match to entry PF01416 PseudoU_synth_1, tRNA pseudouridine synthase, score 120.6, E-value 3.1e-33 282459010455 Pfam match to entry PF01416 PseudoU_synth_1, tRNA pseudouridine synthase, score 121.9, E-value 1.2e-33 282459010456 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 282459010457 4 probable transmembrane helices predicted for SAS2111 by TMHMM2.0 at aa 29-51, 64-86, 112-134 and 248-267 282459010458 Pfam match to entry PF02361 CbiQ, Cobalt transport protein, score 216.1, E-value 5.4e-62 282459010459 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 282459010460 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 282459010461 Walker A/P-loop; other site 282459010462 ATP binding site [chemical binding]; other site 282459010463 Q-loop/lid; other site 282459010464 ABC transporter signature motif; other site 282459010465 Walker B; other site 282459010466 D-loop; other site 282459010467 H-loop/switch region; other site 282459010468 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 195.7, E-value 7.8e-56 282459010469 PS00211 ABC transporters family signature. 282459010470 PS00017 ATP/GTP-binding site motif A (P-loop). 282459010471 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 282459010472 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 282459010473 Walker A/P-loop; other site 282459010474 ATP binding site [chemical binding]; other site 282459010475 Q-loop/lid; other site 282459010476 ABC transporter signature motif; other site 282459010477 Walker B; other site 282459010478 D-loop; other site 282459010479 H-loop/switch region; other site 282459010480 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 189.2, E-value 7.1e-54 282459010481 PS00211 ABC transporters family signature. 282459010482 PS00017 ATP/GTP-binding site motif A (P-loop). 282459010483 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 282459010484 Pfam match to entry PF01196 Ribosomal_L17, Ribosomal protein L17, score 184.4, E-value 1.9e-52 282459010485 PS01167 Ribosomal protein L17 signature. 282459010486 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 282459010487 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 282459010488 alphaNTD homodimer interface [polypeptide binding]; other site 282459010489 alphaNTD - beta interaction site [polypeptide binding]; other site 282459010490 alphaNTD - beta' interaction site [polypeptide binding]; other site 282459010491 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 282459010492 Pfam match to entry PF03118 RNA_pol_A_CTD, Bacterial RNA polymerase, alpha chain C terminal domain, score 124.9, E-value 1.6e-34 282459010493 Pfam match to entry PF01000 RNA_pol_A_bac, RNA polymerase Rpb3/RpoA insert domain, score 188.9, E-value 8.2e-54 282459010494 30S ribosomal protein S11; Validated; Region: PRK05309 282459010495 Pfam match to entry PF00411 Ribosomal_S11, Ribosomal protein S11, score 251.3, E-value 1.4e-72 282459010496 PS00054 Ribosomal protein S11 signature. 282459010497 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 282459010498 30S ribosomal protein S13; Region: bact_S13; TIGR03631 282459010499 Pfam match to entry PF00416 Ribosomal_S13, Ribosomal protein S13/S18, score 200.9, E-value 2.1e-57 282459010500 PS00646 Ribosomal protein S13 signature. 282459010501 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 282459010502 Pfam match to entry PF00444 Ribosomal_L36, Ribosomal protein L36, score 73.0, E-value 6.5e-19 282459010503 PS00828 Ribosomal protein L36 signature. 282459010504 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 282459010505 rRNA binding site [nucleotide binding]; other site 282459010506 predicted 30S ribosome binding site; other site 282459010507 Pfam match to entry PF00575 S1, S1 RNA binding domain, score 59.9, E-value 5.8e-15 282459010508 adenylate kinase; Reviewed; Region: adk; PRK00279 282459010509 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 282459010510 AMP-binding site [chemical binding]; other site 282459010511 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 282459010512 Pfam match to entry PF00406 ADK, Adenylate kinase, score 309.3, E-value 4.7e-90 282459010513 Pfam match to entry PF05191 ADK_lid, Adenylate kinase, active site lid, score 86.4, E-value 6e-23 282459010514 PS00113 Adenylate kinase signature. 282459010515 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 282459010516 Signal peptide predicted for SAS2121 by SignalP 2.0 HMM (Signal peptide probabilty 0.712) with cleavage site probability 0.549 between residues 52 and 53; signal peptide 282459010517 SecY translocase; Region: SecY; pfam00344 282459010518 Pfam match to entry PF00344 secY, eubacterial secY protein, score 646.7, E-value 1.3e-191 282459010519 10 probable transmembrane helices predicted for SAS2121 by TMHMM2.0 at aa 17-39, 68-90, 111-133, 146-168, 175-197, 217-239, 260-282, 309-331, 362-384 and 394-411 282459010520 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 282459010521 PS00756 Protein secY signature 2. 282459010522 PS00755 Protein secY signature 1. 282459010523 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 282459010524 Pfam match to entry PF00256 L15, Ribosomal protein L15, score 56.7, E-value 5.4e-14 282459010525 PS00475 Ribosomal protein L15 signature. 282459010526 Pfam match to entry PF01305 Ribosomal_L15, Ribosomal protein L15 amino terminal region, score 214.5, E-value 1.7e-61 282459010527 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 282459010528 23S rRNA binding site [nucleotide binding]; other site 282459010529 Pfam match to entry PF00327 Ribosomal_L30, Ribosomal protein L30p/L7e, score 70.5, E-value 3.7e-18 282459010530 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 282459010531 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 282459010532 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 282459010533 Pfam match to entry PF03719 Ribosomal_S5_C, Ribosomal protein S5, C-terminal domain, score 157.3, E-value 2.8e-44 282459010534 Pfam match to entry PF00333 Ribosomal_S5, Ribosomal protein S5, N-terminal domain, score 144.6, E-value 1.8e-40 282459010535 PS00585 Ribosomal protein S5 signature. 282459010536 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 282459010537 5S rRNA interface [nucleotide binding]; other site 282459010538 L27 interface [polypeptide binding]; other site 282459010539 23S rRNA interface [nucleotide binding]; other site 282459010540 L5 interface [polypeptide binding]; other site 282459010541 Pfam match to entry PF00861 Ribosomal_L18p, Ribosomal L18p/L5e family, score 178.1, E-value 1.5e-50 282459010542 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 282459010543 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 282459010544 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 282459010545 Pfam match to entry PF00347 Ribosomal_L6, Ribosomal protein L6, score 114.7, E-value 1.8e-31 282459010546 PS00525 Ribosomal protein L6 signature 1. 282459010547 Pfam match to entry PF00347 Ribosomal_L6, Ribosomal protein L6, score 103.4, E-value 4.5e-28 282459010548 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 282459010549 Pfam match to entry PF00410 Ribosomal_S8, Ribosomal protein S8, score 261.6, E-value 1.1e-75 282459010550 PS00053 Ribosomal protein S8 signature. 282459010551 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 282459010552 Pfam match to entry PF00253 Ribosomal_S14, Ribosomal protein S14p/S29e, score 108.6, E-value 1.3e-29 282459010553 PS00527 Ribosomal protein S14 signature. 282459010554 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 282459010555 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 282459010556 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 282459010557 Pfam match to entry PF00673 Ribosomal_L5_C, ribosomal L5P family C-terminus, score 203.8, E-value 2.7e-58 282459010558 Pfam match to entry PF00281 Ribosomal_L5, Ribosomal protein L5, score 125.2, E-value 1.3e-34 282459010559 PS00358 Ribosomal protein L5 signature. 282459010560 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 282459010561 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 282459010562 RNA binding site [nucleotide binding]; other site 282459010563 Pfam match to entry PF00467 KOW, KOW motif, score 47.0, E-value 4.3e-11 282459010564 PS01108 Ribosomal protein L24 signature. 282459010565 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 282459010566 Pfam match to entry PF00238 Ribosomal_L14, Ribosomal protein L14p/L23e, score 268.9, E-value 7e-78 282459010567 PS00049 Ribosomal protein L14 signature. 282459010568 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 282459010569 Pfam match to entry PF00366 Ribosomal_S17, Ribosomal protein S17, score 137.5, E-value 2.6e-38 282459010570 PS00056 Ribosomal protein S17 signature. 282459010571 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 282459010572 23S rRNA interface [nucleotide binding]; other site 282459010573 putative translocon interaction site; other site 282459010574 signal recognition particle (SRP54) interaction site; other site 282459010575 L23 interface [polypeptide binding]; other site 282459010576 trigger factor interaction site; other site 282459010577 Pfam match to entry PF00831 Ribosomal_L29, Ribosomal L29 protein, score 100.2, E-value 4.1e-27 282459010578 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 282459010579 23S rRNA interface [nucleotide binding]; other site 282459010580 5S rRNA interface [nucleotide binding]; other site 282459010581 putative antibiotic binding site [chemical binding]; other site 282459010582 L25 interface [polypeptide binding]; other site 282459010583 L27 interface [polypeptide binding]; other site 282459010584 Pfam match to entry PF00252 Ribosomal_L16, Ribosomal protein L16, score 295.8, E-value 5.6e-86 282459010585 PS00701 Ribosomal protein L16 signature 2. 282459010586 PS00586 Ribosomal protein L16 signature 1. 282459010587 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 282459010588 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 282459010589 G-X-X-G motif; other site 282459010590 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 282459010591 Pfam match to entry PF00189 Ribosomal_S3_C, Ribosomal protein S3, C-terminal domain, score 176.8, E-value 3.8e-50 282459010592 PS00548 Ribosomal protein S3 signature. 282459010593 Pfam match to entry PF00013 KH, KH domain, score 40.8, E-value 3.2e-09 282459010594 Pfam match to entry PF00417 Ribosomal_S3_N, Ribosomal protein S3, N-terminal domain, score 123.1, E-value 5.3e-34 282459010595 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 282459010596 putative translocon binding site; other site 282459010597 protein-rRNA interface [nucleotide binding]; other site 282459010598 Pfam match to entry PF00237 Ribosomal_L22, Ribosomal protein L22p/L17e, score 212.2, E-value 8.4e-61 282459010599 PS00464 Ribosomal protein L22 signature. 282459010600 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 282459010601 Pfam match to entry PF00203 Ribosomal_S19, Ribosomal protein S19, score 182.1, E-value 9.1e-52 282459010602 PS00323 Ribosomal protein S19 signature. 282459010603 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 282459010604 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 282459010605 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 282459010606 Pfam match to entry PF03947 Ribosomal_L2_C, Ribosomal Proteins L2, C-terminal domain, score 318.3, E-value 9.3e-93 282459010607 PS00467 Ribosomal protein L2 signature. 282459010608 Pfam match to entry PF00181 Ribosomal_L2, Ribosomal Proteins L2, RNA binding domain, score 165.1, E-value 1.2e-46 282459010609 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 282459010610 Pfam match to entry PF00276 Ribosomal_L23, Ribosomal protein L23, score 124.7, E-value 1.8e-34 282459010611 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 282459010612 Pfam match to entry PF00573 Ribosomal_L4, Ribosomal protein L4/L1 family, score 282.8, E-value 4.5e-82 282459010613 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 282459010614 Pfam match to entry PF00297 Ribosomal_L3, Ribosomal protein L3, score 293.7, E-value 2.5e-85 282459010615 PS00474 Ribosomal protein L3 signature. 282459010616 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 282459010617 Pfam match to entry PF00338 Ribosomal_S10, Ribosomal protein S10p/S20e, score 206.6, E-value 4e-59 282459010618 PS00361 Ribosomal protein S10 signature. 282459010619 Signal peptide predicted for SAS2143 by SignalP 2.0 HMM (Signal peptide probabilty 0.672) with cleavage site probability 0.236 between residues 31 and 32; signal peptide 282459010620 4 probable transmembrane helices predicted for SAS2143 by TMHMM2.0 at aa 12-34, 38-60, 67-89 and 93-115 282459010621 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 282459010622 Signal peptide predicted for SAS2144 by SignalP 2.0 HMM (Signal peptide probabilty 0.606) with cleavage site probability 0.346 between residues 41 and 42; signal peptide 282459010623 13 probable transmembrane helices predicted for SAS2144 by TMHMM2.0 at aa 20-42, 57-76, 83-105, 110-132, 141-163, 178-195, 202-221, 252-274, 295-317, 322-344, 349-371, 391-413 and 425-442 282459010624 Pfam match to entry PF00860 xan_ur_permease, Permease family, score 77.0, E-value 4e-20 282459010625 DNA topoisomerase III; Provisional; Region: PRK07726 282459010626 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 282459010627 active site 282459010628 putative interdomain interaction site [polypeptide binding]; other site 282459010629 putative metal-binding site [ion binding]; other site 282459010630 putative nucleotide binding site [chemical binding]; other site 282459010631 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 282459010632 domain I; other site 282459010633 DNA binding groove [nucleotide binding] 282459010634 phosphate binding site [ion binding]; other site 282459010635 domain II; other site 282459010636 domain III; other site 282459010637 nucleotide binding site [chemical binding]; other site 282459010638 catalytic site [active] 282459010639 domain IV; other site 282459010640 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 282459010641 PS00196 Type-1 copper (blue) proteins signature. 282459010642 Pfam match to entry PF01396 zf-C4_Topoisom, Topoisomerase DNA binding C4 zinc finger, score 14.3, E-value 0.0023 282459010643 Pfam match to entry PF01131 Topoisom_bac, DNA topoisomerase, score 306.1, E-value 4.5e-89 282459010644 Pfam match to entry PF01751 Toprim, Toprim domain, score 80.1, E-value 4.7e-21 282459010645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459010646 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 282459010647 Coenzyme A binding pocket [chemical binding]; other site 282459010648 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 32.3, E-value 1.2e-06 282459010649 Signal peptide predicted for SAS2147 by SignalP 2.0 HMM (Signal peptide probabilty 0.763) with cleavage site probability 0.364 between residues 26 and 27; signal peptide 282459010650 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 282459010651 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 282459010652 9 probable transmembrane helices predicted for SAS2147 by TMHMM2.0 at aa 7-29, 34-53, 60-77, 114-136, 157-179, 184-201, 208-230, 235-257 and 269-286 282459010653 Predicted permeases [General function prediction only]; Region: COG0679 282459010654 Pfam match to entry PF03547 Auxin_eff, Auxin Efflux Carrier, score 3.7, E-value 2.2e-06 282459010655 10 probable transmembrane helices predicted for SAS2148 by TMHMM2.0 at aa 5-24, 31-48, 58-80, 89-111, 116-138, 158-180, 190-211, 223-242, 252-269 and 276-298 282459010656 4 probable transmembrane helices predicted for SAS2150 by TMHMM2.0 at aa 4-21, 28-50, 55-73 and 82-104 282459010657 Signal peptide predicted for SAS2151 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.739 between residues 30 and 31; signal peptide 282459010658 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 282459010659 Protein export membrane protein; Region: SecD_SecF; cl14618 282459010660 Pfam match to entry PF00873 ACR_tran, AcrB/AcrD/AcrF family, score 748.4, E-value 3.2e-222 282459010661 12 probable transmembrane helices predicted for SAS2151 by TMHMM2.0 at aa 13-32, 369-391, 398-415, 420-438, 476-498, 508-530, 561-583, 886-908, 913-935, 945-967, 988-1008 and 1023-1045 282459010662 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 282459010663 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 282459010664 Pfam match to entry PF02388 FemAB, FemAB family, score 135.6, E-value 9.7e-38 282459010665 Signal peptide predicted for SAS2153 by SignalP 2.0 HMM (Signal peptide probabilty 0.697) with cleavage site probability 0.553 between residues 29 and 30; signal peptide 282459010666 3 probable transmembrane helices predicted for SAS2153 by TMHMM2.0 at aa 5-27, 31-50 and 57-79 282459010667 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 282459010668 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 282459010669 Pfam match to entry PF01047 MarR, MarR family, score 52.0, E-value 1.4e-12 282459010670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459010671 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282459010672 putative substrate translocation pore; other site 282459010673 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -118.7, E-value 0.0044 282459010674 12 probable transmembrane helices predicted for SAS2156 by TMHMM2.0 at aa 20-42, 52-71, 83-100, 113-135, 142-164, 168-190, 220-242, 252-274, 283-302, 307-326, 347-369 and 374-393 282459010675 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282459010676 Transcriptional regulators [Transcription]; Region: MarR; COG1846 282459010677 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 282459010678 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282459010679 FeS/SAM binding site; other site 282459010680 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 282459010681 Pfam match to entry PF04055 Radical_SAM, Radical SAM superfamily, score 133.6, E-value 3.6e-37 282459010682 PS01305 moaA / nifB / pqqE family signature. 282459010683 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 282459010684 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 282459010685 GTP binding site; other site 282459010686 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 282459010687 MoaE interaction surface [polypeptide binding]; other site 282459010688 MoeB interaction surface [polypeptide binding]; other site 282459010689 thiocarboxylated glycine; other site 282459010690 Pfam match to entry PF02597 ThiS, ThiS family, score 63.8, E-value 3.9e-16 282459010691 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 282459010692 MoaE homodimer interface [polypeptide binding]; other site 282459010693 MoaD interaction [polypeptide binding]; other site 282459010694 active site residues [active] 282459010695 Pfam match to entry PF02391 MoaE, MoaE protein, score 195.2, E-value 1.1e-55 282459010696 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 282459010697 Pfam match to entry PF03205 MobB, Molybdopterin guanine dinucleotide synthesis protein B, score 144.9, E-value 1.5e-40 282459010698 PS00017 ATP/GTP-binding site motif A (P-loop). 282459010699 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 282459010700 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 282459010701 dimer interface [polypeptide binding]; other site 282459010702 putative functional site; other site 282459010703 putative MPT binding site; other site 282459010704 Pfam match to entry PF03454 MoeA_C, MoeA C-terminal region (domain IV), score 74.5, E-value 2.4e-19 282459010705 Pfam match to entry PF00994 MoCF_biosynth, Probable molybdopterin binding domain, score 188.6, E-value 1e-53 282459010706 Pfam match to entry PF03453 MoeA_N, MoeA N-terminal region (domain I and II), score 275.3, E-value 8.3e-80 282459010707 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 282459010708 trimer interface [polypeptide binding]; other site 282459010709 dimer interface [polypeptide binding]; other site 282459010710 putative active site [active] 282459010711 Pfam match to entry PF01967 MoaC, MoaC family, score 261.4, E-value 1.2e-75 282459010712 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 282459010713 MPT binding site; other site 282459010714 trimer interface [polypeptide binding]; other site 282459010715 Pfam match to entry PF00994 MoCF_biosynth, Probable molybdopterin binding domain, score 188.3, E-value 1.3e-53 282459010716 PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 282459010717 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 282459010718 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 282459010719 ATP binding site [chemical binding]; other site 282459010720 substrate interface [chemical binding]; other site 282459010721 Pfam match to entry PF05237 MoeZ_MoeB, MoeZ/MoeB domain, score 106.3, E-value 6e-29 282459010722 PS00017 ATP/GTP-binding site motif A (P-loop). 282459010723 Pfam match to entry PF00899 ThiF, ThiF family, score 152.5, E-value 7.8e-43 282459010724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282459010725 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 282459010726 Walker A/P-loop; other site 282459010727 ATP binding site [chemical binding]; other site 282459010728 Q-loop/lid; other site 282459010729 ABC transporter signature motif; other site 282459010730 Walker B; other site 282459010731 D-loop; other site 282459010732 H-loop/switch region; other site 282459010733 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 167.2, E-value 2.9e-47 282459010734 PS00211 ABC transporters family signature. 282459010735 PS00017 ATP/GTP-binding site motif A (P-loop). 282459010736 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 282459010737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459010738 dimer interface [polypeptide binding]; other site 282459010739 conserved gate region; other site 282459010740 putative PBP binding loops; other site 282459010741 ABC-ATPase subunit interface; other site 282459010742 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 66.9, E-value 4.4e-17 282459010743 5 probable transmembrane helices predicted for SAS2168 by TMHMM2.0 at aa 10-32, 45-67, 82-104, 145-167 and 193-215 282459010744 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 282459010745 Signal peptide predicted for SAS2169 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.370 between residues 23 and 24; signal peptide 282459010746 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 282459010747 substrate binding pocket [chemical binding]; other site 282459010748 membrane-bound complex binding site; other site 282459010749 hinge residues; other site 282459010750 Pfam match to entry PF01547 SBP_bac_1, Bacterial extracellular solute-binding protein, score 40.5, E-value 3.9e-09 282459010751 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459010752 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 282459010753 Pfam match to entry PF02634 FdhD-NarQ, FdhD/NarQ family, score 302.7, E-value 4.8e-88 282459010754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459010755 Coenzyme A binding pocket [chemical binding]; other site 282459010756 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 42.5, E-value 1e-09 282459010757 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 282459010758 Signal peptide predicted for SAS2172 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.367 between residues 31 and 32; signal peptide 282459010759 Pfam match to entry PF02632 BioY, BioY family, score 110.1, E-value 4.6e-30 282459010760 6 probable transmembrane helices predicted for SAS2172 by TMHMM2.0 at aa 7-25, 29-48, 55-74, 78-100, 112-134 and 149-171 282459010761 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 282459010762 active site 282459010763 dimerization interface [polypeptide binding]; other site 282459010764 Pfam match to entry PF01156 IU_nuc_hydro, Inosine-uridine preferring nucleoside hydrolase, score 84.2, E-value 2.8e-22 282459010765 Signal peptide predicted for SAS2174 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.601 between residues 28 and 29; signal peptide 282459010766 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 282459010767 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 282459010768 intersubunit interface [polypeptide binding]; other site 282459010769 Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, score 122.0, E-value 1.1e-33 282459010770 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459010771 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 282459010772 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 282459010773 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 282459010774 Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase, C-terminal domain, score 29.9, E-value 1.5e-06 282459010775 Pfam match to entry PF02770 Acyl-CoA_dh_M, Acyl-CoA dehydrogenase, middle domain, score 13.5, E-value 2.3e-07 282459010776 1 probable transmembrane helix predicted for SAS2176 by TMHMM2.0 at aa 7-26 282459010777 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 282459010778 Pfam match to entry PF03253 UT, Urea transporter, score 517.9, E-value 7.6e-153 282459010779 8 probable transmembrane helices predicted for SAS2177 by TMHMM2.0 at aa 21-43, 89-106, 113-135, 171-193, 198-215, 225-242, 249-267 and 272-294 282459010780 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 282459010781 alpha-gamma subunit interface [polypeptide binding]; other site 282459010782 beta-gamma subunit interface [polypeptide binding]; other site 282459010783 Pfam match to entry PF00547 urease_gamma, Urease, gamma subunit, score 211.4, E-value 1.5e-60 282459010784 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 282459010785 gamma-beta subunit interface [polypeptide binding]; other site 282459010786 alpha-beta subunit interface [polypeptide binding]; other site 282459010787 Pfam match to entry PF00699 Urease_beta, Urease beta subunit, score 231.5, E-value 1.3e-66 282459010788 urease subunit alpha; Reviewed; Region: ureC; PRK13207 282459010789 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 282459010790 subunit interactions [polypeptide binding]; other site 282459010791 active site 282459010792 flap region; other site 282459010793 Pfam match to entry PF00449 urease, Urease alpha-subunit, N-terminal domain, score 289.3, E-value 4.9e-84 282459010794 PS00017 ATP/GTP-binding site motif A (P-loop). 282459010795 Pfam match to entry PF01979 Amidohydro_1, Amidohydrolase family, score 295.9, E-value 5.3e-86 282459010796 PS01120 Urease nickel ligands signature. 282459010797 PS00145 Urease active site. 282459010798 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 282459010799 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 282459010800 dimer interface [polypeptide binding]; other site 282459010801 catalytic residues [active] 282459010802 Pfam match to entry PF02814 UreE_N, UreE urease accessory protein, N-terminal domain, score 99.5, E-value 7e-27 282459010803 Pfam match to entry PF05194 UreE_C, UreE urease accessory protein, C-terminal domain, score 129.6, E-value 5.8e-36 282459010804 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 282459010805 UreF; Region: UreF; pfam01730 282459010806 Pfam match to entry PF01730 UreF, UreF, score 253.3, E-value 3.4e-73 282459010807 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 282459010808 Pfam match to entry PF01495 HypB_UreG, HypB/UreG nucleotide-binding domain, score 275.0, E-value 9.9e-80 282459010809 PS00017 ATP/GTP-binding site motif A (P-loop). 282459010810 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 282459010811 Pfam match to entry PF01774 UreD, UreD urease accessory protein, score 209.8, E-value 4.3e-60 282459010812 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282459010813 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282459010814 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282459010815 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 282459010816 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 282459010817 Predicted helix-turn-helix motif for SAS2188 with score 1261.000, SD 3.48 at aa 313-334, sequence YTIKQIIQRLGVNPENLHIIVT 282459010818 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 35.5, E-value 1.3e-07 282459010819 Signal peptide predicted for SAS2189 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.985 between residues 27 and 28; signal peptide 282459010820 Surface antigen [General function prediction only]; Region: COG3942 282459010821 CHAP domain; Region: CHAP; pfam05257 282459010822 Pfam match to entry PF05257 CHAP, CHAP domain, score 170.4, E-value 3.1e-48 282459010823 Signal peptide predicted for SAS2191 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.694 between residues 42 and 43; signal peptide 282459010824 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 282459010825 10 probable transmembrane helices predicted for SAS2191 by TMHMM2.0 at aa 7-29, 33-53, 66-88, 108-130, 187-209, 229-251, 258-276, 310-332, 352-383 and 433-455 282459010826 Pfam match to entry PF03553 Na_H_antiporter, Na+/H+ antiporter family, score 329.5, E-value 3.9e-96 282459010827 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 282459010828 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 282459010829 Pfam match to entry PF02317 Octopine_DH, NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain, score 42.7, E-value 8.5e-10 282459010830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 282459010831 3 probable transmembrane helices predicted for SAS2193 by TMHMM2.0 at aa 22-44, 65-87 and 92-123 282459010832 Signal peptide predicted for SAS2194 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.882 between residues 27 and 28; signal peptide 282459010833 Surface antigen [General function prediction only]; Region: COG3942 282459010834 CHAP domain; Region: CHAP; pfam05257 282459010835 Pfam match to entry PF05257 CHAP, CHAP domain, score 173.1, E-value 4.7e-49 282459010836 1 probable transmembrane helix predicted for SAS2195 by TMHMM2.0 at aa 4-21 282459010837 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 282459010838 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 282459010839 putative ligand binding site [chemical binding]; other site 282459010840 putative NAD binding site [chemical binding]; other site 282459010841 catalytic site [active] 282459010842 Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 105.5, E-value 1.1e-28 282459010843 Pfam match to entry PF02826 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 225.8, E-value 6.4e-65 282459010844 PS00017 ATP/GTP-binding site motif A (P-loop). 282459010845 Signal peptide predicted for SAS2197 by SignalP 2.0 HMM (Signal peptide probabilty 0.813) with cleavage site probability 0.370 between residues 30 and 31; signal peptide 282459010846 hypothetical protein; Provisional; Region: PRK06753 282459010847 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 282459010848 Pfam match to entry PF01360 Monooxygenase, Monooxygenase, score 111.0, E-value 2.4e-30 282459010849 Signal peptide predicted for SAS2198 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.701 between residues 34 and 35; signal peptide 282459010850 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 282459010851 Lysozyme subfamily 2; Region: LYZ2; smart00047 282459010852 Pfam match to entry PF01832 Amidase_4, Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase, score 140.9, E-value 2.4e-39 282459010853 1 probable transmembrane helix predicted for SAS2198 by TMHMM2.0 at aa 7-26 282459010854 Signal peptide predicted for SAS2199 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.771 between residues 39 and 40; signal peptide 282459010855 3 probable transmembrane helices predicted for SAS2199 by TMHMM2.0 at aa 12-29, 34-53 and 60-82 282459010856 Uncharacterized conserved protein [Function unknown]; Region: COG2427 282459010857 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 282459010858 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 282459010859 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 282459010860 4Fe-4S binding domain; Region: Fer4; pfam00037 282459010861 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 282459010862 [4Fe-4S] binding site [ion binding]; other site 282459010863 molybdopterin cofactor binding site; other site 282459010864 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 282459010865 molybdopterin cofactor binding site; other site 282459010866 Pfam match to entry PF01568 Molydop_binding, Molydopterin dinucleotide binding domain, score 105.5, E-value 1.1e-28 282459010867 Pfam match to entry PF00384 molybdopterin, Molybdopterin oxidoreductase, score 326.6, E-value 3.1e-95 282459010868 Pfam match to entry PF04879 Molybdop_Fe4S4, Molybdopterin oxidoreductase Fe4S4 domain, score 94.1, E-value 2.9e-25 282459010869 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 282459010870 Pfam match to entry PF00037 fer4, 4Fe-4S binding domain, score 30.9, E-value 3e-06 282459010871 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 282459010872 Pfam match to entry PF00037 fer4, 4Fe-4S binding domain, score 13.3, E-value 0.002 282459010873 Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domain, score 21.8, E-value 0.0017 282459010874 Signal peptide predicted for SAS2202 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.854 between residues 34 and 35; signal peptide 282459010875 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 282459010876 Pfam match to entry PF03816 LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain, score 262.6, E-value 5.7e-76 282459010877 1 probable transmembrane helix predicted for SAS2202 by TMHMM2.0 at aa 15-34 282459010878 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 282459010879 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 282459010880 active site 282459010881 Pfam match to entry PF00459 inositol_P, Inositol monophosphatase family, score 81.2, E-value 2.2e-21 282459010882 Predicted transcriptional regulator [Transcription]; Region: COG2378 282459010883 HTH domain; Region: HTH_11; pfam08279 282459010884 Pfam match to entry PF00455 deoR, Bacterial regulatory proteins, deoR family, score 29.1, E-value 1.6e-08 282459010885 Predicted helix-turn-helix motif for SAS2204 with score 1386.000, SD 3.91 at aa 20-41, sequence MTALELAKYCNVSKRTILRDID 282459010886 Probable gene remnant. Similar to the N-terminal rgions of Staphylococcus aureus prophage phiPV83 transposase SWALL:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 8.2e-36, 82.11% id in 123 aa, and Staphylococcus haemolyticus hypothetical 32.7 kDa protein SWALL:Q54270 (EMBL:U35635) (273 aa) fasta scores: E(): 9.9e-31, 69.91% id in 123 aa; transposase (fragment) 282459010887 CAAX protease self-immunity; Region: Abi; pfam02517 282459010888 7 probable transmembrane helices predicted for SAS2206 by TMHMM2.0 at aa 19-41, 51-73, 92-114, 139-161, 173-192, 196-215 and 222-244 282459010889 Pfam match to entry PF02517 Abi, CAAX amino terminal protease family, score 65.3, E-value 1.3e-16 282459010890 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 282459010891 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 282459010892 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 282459010893 putative active site [active] 282459010894 Pfam match to entry PF01418 HTH_6, Helix-turn-helix domain, rpiR family, score 91.7, E-value 1.6e-24 282459010895 Predicted helix-turn-helix motif for SAS2208 with score 978.000, SD 2.52 at aa 36-57, sequence MRSQDLASLLDISTSSVIRFSK 282459010896 Pfam match to entry PF01380 SIS, SIS domain, score 14.9, E-value 0.0031 282459010897 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 282459010898 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score 412.5, E-value 4.1e-121 282459010899 11 probable transmembrane helices predicted for SAS2209 by TMHMM2.0 at aa 15-32, 39-61, 122-141, 153-175, 195-217, 237-259, 269-291, 329-351, 361-383, 403-425 and 430-449 282459010900 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459010901 PS00218 Amino acid permeases signature. 282459010902 3 probable transmembrane helices predicted for SAS2210 by TMHMM2.0 at aa 5-27, 36-58 and 73-106 282459010903 Signal peptide predicted for SAS2211 by SignalP 2.0 HMM (Signal peptide probabilty 0.948) with cleavage site probability 0.783 between residues 30 and 31; signal peptide 282459010904 2 probable transmembrane helices predicted for SAS2211 by TMHMM2.0 at aa 5-24 and 39-58 282459010905 Signal peptide predicted for SAS2212 by SignalP 2.0 HMM (Signal peptide probabilty 0.645) with cleavage site probability 0.498 between residues 28 and 29; signal peptide 282459010906 2 probable transmembrane helices predicted for SAS2212 by TMHMM2.0 at aa 5-27 and 37-59 282459010907 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 282459010908 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459010909 active site 282459010910 motif I; other site 282459010911 motif II; other site 282459010912 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 106.6, E-value 4.9e-29 282459010913 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 282459010914 Signal peptide predicted for SAS2214 by SignalP 2.0 HMM (Signal peptide probabilty 0.945) with cleavage site probability 0.341 between residues 36 and 37; signal peptide 282459010915 Sodium Bile acid symporter family; Region: SBF; pfam01758 282459010916 9 probable transmembrane helices predicted for SAS2214 by TMHMM2.0 at aa 5-27, 37-54, 67-86, 96-118, 123-145, 160-182, 189-211, 221-243 and 264-286 282459010917 Pfam match to entry PF01758 SBF, Sodium Bile acid symporter family, score 193.7, E-value 3e-55 282459010918 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 282459010919 Signal peptide predicted for SAS2216 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.436 between residues 41 and 42; signal peptide 282459010920 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282459010921 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282459010922 active site turn [active] 282459010923 phosphorylation site [posttranslational modification] 282459010924 PS00017 ATP/GTP-binding site motif A (P-loop). 282459010925 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 58.3, E-value 1.7e-14 282459010926 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282459010927 10 probable transmembrane helices predicted for SAS2216 by TMHMM2.0 at aa 7-29, 56-78, 85-107, 127-149, 170-192, 202-219, 304-321, 326-343, 350-372 and 382-404 282459010928 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 228.0, E-value 1.5e-65 282459010929 PS00079 Multicopper oxidases signature 1. 282459010930 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 282459010931 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 282459010932 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 282459010933 putative active site [active] 282459010934 Pfam match to entry PF01418 HTH_6, Helix-turn-helix domain, rpiR family, score 47.3, E-value 3.5e-11 282459010935 Predicted helix-turn-helix motif for SAS2217 with score 1106.000, SD 2.95 at aa 35-56, sequence MKIQDLAQFTHASNATIHRFTR 282459010936 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 282459010937 putative hydrophobic ligand binding site [chemical binding]; other site 282459010938 Pfam match to entry PF05146 DUF704, Aha1 domain, score 108.4, E-value 1.5e-29 282459010939 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 282459010940 Pfam match to entry PF03553 Na_H_antiporter, Na+/H+ antiporter family, score 236.3, E-value 4.7e-68 282459010941 10 probable transmembrane helices predicted for SAS2219 by TMHMM2.0 at aa 31-50, 54-73, 86-108, 128-150, 213-235, 250-272, 274-296, 311-333, 395-417 and 422-444 282459010942 Signal peptide predicted for SAS2220 by SignalP 2.0 HMM (Signal peptide probabilty 0.958) with cleavage site probability 0.289 between residues 41 and 42; signal peptide 282459010943 6 probable transmembrane helices predicted for SAS2220 by TMHMM2.0 at aa 3-25, 29-51, 64-86, 92-114, 134-156 and 160-182 282459010944 oxidoreductase; Provisional; Region: PRK07985 282459010945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 282459010946 NAD(P) binding site [chemical binding]; other site 282459010947 active site 282459010948 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 176.3, E-value 5.3e-50 282459010949 PS00061 Short-chain dehydrogenases/reductases family signature. 282459010950 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 282459010951 amidohydrolase; Region: amidohydrolases; TIGR01891 282459010952 metal binding site [ion binding]; metal-binding site 282459010953 dimer interface [polypeptide binding]; other site 282459010954 Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40, score 355.3, E-value 7e-104 282459010955 imidazolonepropionase; Validated; Region: PRK09356 282459010956 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 282459010957 active site 282459010958 Pfam match to entry PF01979 Amidohydro_1, Amidohydrolase family, score 11.3, E-value 4.4e-05 282459010959 urocanate hydratase; Provisional; Region: PRK05414 282459010960 Pfam match to entry PF01175 Urocanase, Urocanase, score 1192.0, E-value 0 282459010961 Transcriptional regulator [Transcription]; Region: LysR; COG0583 282459010962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 282459010963 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 282459010964 dimerization interface [polypeptide binding]; other site 282459010965 Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 73.0, E-value 6.5e-19 282459010966 Predicted helix-turn-helix motif for SAS2225 with score 1212.000, SD 3.31 at aa 16-37, sequence NSFTKAAQFLHISQPSLTATIK 282459010967 PS00044 Bacterial regulatory proteins, lysR family signature. 282459010968 Pfam match to entry PF03466 LysR_substrate, LysR substrate binding domain, score 105.4, E-value 1.1e-28 282459010969 formimidoylglutamase; Provisional; Region: PRK13775 282459010970 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 282459010971 putative active site [active] 282459010972 putative metal binding site [ion binding]; other site 282459010973 Pfam match to entry PF00491 arginase, Arginase family, score 24.7, E-value 8.4e-13 282459010974 PS00148 Arginase family signature 2. 282459010975 PS00147 Arginase family signature 1. 282459010976 Signal peptide predicted for SAS2227 by SignalP 2.0 HMM (Signal peptide probabilty 0.766) with cleavage site probability 0.438 between residues 34 and 35; signal peptide 282459010977 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 282459010978 8 probable transmembrane helices predicted for SAS2227 by TMHMM2.0 at aa 7-29, 41-63, 83-105, 115-137, 150-172, 176-195, 202-221 and 231-253 282459010979 Pfam match to entry PF02517 Abi, CAAX amino terminal protease family, score 23.1, E-value 0.00015 282459010980 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 282459010981 tetramer (dimer of dimers) interface [polypeptide binding]; other site 282459010982 active site 282459010983 dimer interface [polypeptide binding]; other site 282459010984 Pfam match to entry PF06026 Rib_5-P_isom_A, Ribose 5-phosphate isomerase A (phosphoriboisomerase A), score 326.8, E-value 2.6e-95 282459010985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 282459010986 MOSC domain; Region: MOSC; pfam03473 282459010987 3-alpha domain; Region: 3-alpha; pfam03475 282459010988 Pfam match to entry PF03473 MOSC, MOSC domain, score 144.4, E-value 2.1e-40 282459010989 Pfam match to entry PF03475 3-alpha, 3-alpha domain, score 70.0, E-value 5.3e-18 282459010990 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 282459010991 active site 282459010992 catalytic residues [active] 282459010993 Pfam match to entry PF01263 Aldose_epim, Aldose 1-epimerase, score 341.5, E-value 1e-99 282459010994 PS00545 Aldose 1-epimerase active site. 282459010995 Uncharacterized conserved protein [Function unknown]; Region: COG1742 282459010996 Pfam match to entry PF02694 UPF0060, Uncharacterized BCR, YnfA/UPF0060 family, score 187.6, E-value 2e-53 282459010997 4 probable transmembrane helices predicted for SAS2231 by TMHMM2.0 at aa 4-26, 33-55, 60-79 and 86-105 282459010998 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 282459010999 Signal peptide predicted for SAS2232 by SignalP 2.0 HMM (Signal peptide probabilty 0.616) with cleavage site probability 0.210 between residues 40 and 41; signal peptide 282459011000 7 probable transmembrane helices predicted for SAS2232 by TMHMM2.0 at aa 21-38, 178-200, 235-257, 277-299, 312-331, 336-355 and 367-386 282459011001 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 282459011002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282459011003 Walker A/P-loop; other site 282459011004 ATP binding site [chemical binding]; other site 282459011005 Q-loop/lid; other site 282459011006 ABC transporter signature motif; other site 282459011007 Walker B; other site 282459011008 D-loop; other site 282459011009 H-loop/switch region; other site 282459011010 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 282459011011 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 187.2, E-value 2.8e-53 282459011012 PS00211 ABC transporters family signature. 282459011013 PS00017 ATP/GTP-binding site motif A (P-loop). 282459011014 Predicted membrane protein [Function unknown]; Region: COG3152 282459011015 Pfam match to entry PF05656 DUF805, Protein of unknown function (DUF805), score 222.8, E-value 5.2e-64 282459011016 4 probable transmembrane helices predicted for SAS2234 by TMHMM2.0 at aa 36-58, 68-90, 110-129 and 144-166 282459011017 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 282459011018 active site 282459011019 DNA binding site [nucleotide binding] 282459011020 Pfam match to entry PF02245 Pur_DNA_glyco, Methylpurine-DNA glycosylase (MPG), score 155.4, E-value 1e-43 282459011021 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 282459011022 Pfam match to entry PF03616 Glt_symporter, Sodium/glutamate symporter, score 801.8, E-value 2.6e-238 282459011023 11 probable transmembrane helices predicted for SAS2236 by TMHMM2.0 at aa 5-27, 34-56, 66-88, 95-117, 158-180, 219-241, 245-262, 282-304, 308-330, 339-361 and 376-398 282459011024 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 282459011025 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 282459011026 homotetramer interface [polypeptide binding]; other site 282459011027 FMN binding site [chemical binding]; other site 282459011028 homodimer contacts [polypeptide binding]; other site 282459011029 putative active site [active] 282459011030 putative substrate binding site [chemical binding]; other site 282459011031 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 282459011032 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 282459011033 oligomer interface [polypeptide binding]; other site 282459011034 metal binding site [ion binding]; metal-binding site 282459011035 metal binding site [ion binding]; metal-binding site 282459011036 putative Cl binding site [ion binding]; other site 282459011037 aspartate ring; other site 282459011038 basic sphincter; other site 282459011039 hydrophobic gate; other site 282459011040 periplasmic entrance; other site 282459011041 Pfam match to entry PF01544 CorA, CorA-like Mg2+ transporter protein, score 127.4, E-value 2.7e-35 282459011042 2 probable transmembrane helices predicted for SAS2238 by TMHMM2.0 at aa 255-277 and 287-309 282459011043 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 282459011044 active site 282459011045 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 282459011046 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 282459011047 4 probable transmembrane helices predicted for SAS2242 by TMHMM2.0 at aa 32-54, 105-127, 134-156 and 183-205 282459011048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459011049 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 282459011050 putative substrate translocation pore; other site 282459011051 15 probable transmembrane helices predicted for SAS2243 by TMHMM2.0 at aa 5-25, 141-163, 178-200, 207-229, 234-256, 269-288, 293-315, 328-345, 360-377, 398-420, 425-447, 454-473, 488-510, 531-548 and 599-621 282459011052 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -109.9, E-value 0.0023 282459011053 Signal peptide predicted for SAS2244 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.709 between residues 33 and 34; signal peptide 282459011054 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 282459011055 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 282459011056 HlyD family secretion protein; Region: HlyD_3; pfam13437 282459011057 lipoyl-biotinyl attachment site [posttranslational modification]; other site 282459011058 1 probable transmembrane helix predicted for SAS2244 by TMHMM2.0 at aa 4-26 282459011059 Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 27.7, E-value 2.9e-05 282459011060 Predicted helix-turn-helix motif for SAS2245 with score 1145.000, SD 3.09 at aa 25-46, sequence ISTKMICAYCNINRSTFYDYYK 282459011061 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 282459011062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459011063 putative substrate translocation pore; other site 282459011064 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -88.8, E-value 0.00049 282459011065 11 probable transmembrane helices predicted for SAS2246 by TMHMM2.0 at aa 13-35, 50-69, 81-103, 139-161, 168-186, 222-244, 257-279, 289-311, 313-335, 350-367 and 374-393 282459011066 Predicted membrane protein [Function unknown]; Region: COG4640 282459011067 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 282459011068 1 probable transmembrane helix predicted for SAS2247 by TMHMM2.0 at aa 51-70 282459011069 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 282459011070 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 282459011071 putative Zn2+ binding site [ion binding]; other site 282459011072 putative DNA binding site [nucleotide binding]; other site 282459011073 Pfam match to entry PF01047 MarR, MarR family, score 40.2, E-value 4.8e-09 282459011074 Predicted helix-turn-helix motif for SAS2248 with score 1618.000, SD 4.70 at aa 52-73, sequence LTISEITQRQGVNKAAVSRRIK 282459011075 Uncharacterized conserved protein [Function unknown]; Region: COG1434 282459011076 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 282459011077 putative active site [active] 282459011078 6 probable transmembrane helices predicted for SAS2249 by TMHMM2.0 at aa 5-27, 29-46, 50-67, 88-110, 115-137 and 298-320 282459011079 Pfam match to entry PF02698 DUF218, Uncharacterized ACR, COG1434, score -11.5, E-value 8.2e-07 282459011080 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 282459011081 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282459011082 Walker A/P-loop; other site 282459011083 ATP binding site [chemical binding]; other site 282459011084 Q-loop/lid; other site 282459011085 ABC transporter signature motif; other site 282459011086 Walker B; other site 282459011087 D-loop; other site 282459011088 H-loop/switch region; other site 282459011089 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 197.7, E-value 2e-56 282459011090 PS00017 ATP/GTP-binding site motif A (P-loop). 282459011091 Signal peptide predicted for SAS2251 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.557 between residues 41 and 42; signal peptide 282459011092 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 282459011093 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 282459011094 FtsX-like permease family; Region: FtsX; pfam02687 282459011095 Pfam match to entry PF02687 FtsX, Predicted permease, score 60.8, E-value 3.1e-15 282459011096 4 probable transmembrane helices predicted for SAS2251 by TMHMM2.0 at aa 13-35, 232-254, 274-296 and 316-338 282459011097 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282459011098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459011099 active site 282459011100 phosphorylation site [posttranslational modification] 282459011101 intermolecular recognition site; other site 282459011102 dimerization interface [polypeptide binding]; other site 282459011103 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282459011104 DNA binding site [nucleotide binding] 282459011105 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 111.9, E-value 1.3e-30 282459011106 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 89.7, E-value 6.1e-24 282459011107 PS00230 Neuraxin and MAP1B proteins repeated region signature. 282459011108 Signal peptide predicted for SAS2253 by SignalP 2.0 HMM (Signal peptide probabilty 0.628) with cleavage site probability 0.284 between residues 32 and 33; signal peptide 282459011109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 282459011110 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 282459011111 dimerization interface [polypeptide binding]; other site 282459011112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 282459011113 dimer interface [polypeptide binding]; other site 282459011114 phosphorylation site [posttranslational modification] 282459011115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459011116 ATP binding site [chemical binding]; other site 282459011117 Mg2+ binding site [ion binding]; other site 282459011118 G-X-G motif; other site 282459011119 2 probable transmembrane helices predicted for SAS2253 by TMHMM2.0 at aa 10-32 and 165-187 282459011120 Pfam match to entry PF00672 HAMP, HAMP domain, score 55.2, E-value 1.5e-13 282459011121 Pfam match to entry PF00512 HisKA, His Kinase A (phosphoacceptor) domain, score 44.8, E-value 2e-10 282459011122 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 111.1, E-value 2.2e-30 282459011123 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 282459011124 LytTr DNA-binding domain; Region: LytTR; smart00850 282459011125 Pfam match to entry PF04397 LytTR, LytTr DNA-binding domain, score 110.1, E-value 4.4e-30 282459011126 Signal peptide predicted for SAS2255 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.866 between residues 27 and 28; signal peptide 282459011127 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 282459011128 4 probable transmembrane helices predicted for SAS2255 by TMHMM2.0 at aa 7-26, 53-75, 87-109 and 113-135 282459011129 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 282459011130 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 282459011131 Pfam match to entry PF06039 Mqo, Malate:quinone oxidoreductase (Mqo), score 1285.6, E-value 0 282459011132 Signal peptide predicted for SAS2257 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.930 between residues 40 and 41; signal peptide 282459011133 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 282459011134 L-lactate permease; Region: Lactate_perm; cl00701 282459011135 13 probable transmembrane helices predicted for SAS2257 by TMHMM2.0 at aa 12-34, 38-60, 67-89, 127-149, 156-178, 193-215, 228-245, 250-267, 295-317, 349-371, 392-414, 429-448 and 512-529 282459011136 Pfam match to entry PF02652 Lactate_perm, L-lactate permease, score 657.9, E-value 5.6e-195 282459011137 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 282459011138 Pfam match to entry PF04464 glyphos_transf, CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase, score 111.1, E-value 2.2e-30 282459011139 Signal peptide predicted for SAS2259 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.471 between residues 19 and 20; signal peptide 282459011140 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459011141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459011142 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 282459011143 Coenzyme A binding pocket [chemical binding]; other site 282459011144 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 76.8, E-value 4.7e-20 282459011145 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 282459011146 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 282459011147 NAD(P) binding site [chemical binding]; other site 282459011148 Pfam match to entry PF00107 ADH_zinc_N, Zinc-binding dehydrogenase, score 130.6, E-value 3e-36 282459011149 H+ Antiporter protein; Region: 2A0121; TIGR00900 282459011150 10 probable transmembrane helices predicted for SAS2262 by TMHMM2.0 at aa 43-65, 75-97, 99-118, 155-177, 216-238, 248-270, 277-299, 304-326, 339-361 and 365-387 282459011151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459011152 Coenzyme A binding pocket [chemical binding]; other site 282459011153 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 44.2, E-value 3.1e-10 282459011154 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 282459011155 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 282459011156 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282459011157 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 91.7, E-value 1.5e-24 282459011158 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 282459011159 4 probable transmembrane helices predicted for SAS2265 by TMHMM2.0 at aa 5-22, 37-56, 68-90 and 105-127 282459011160 Predicted membrane protein [Function unknown]; Region: COG1511 282459011161 Signal peptide predicted for SAS2266 by SignalP 2.0 HMM (Signal peptide probabilty 0.958) with cleavage site probability 0.372 between residues 28 and 29; signal peptide 282459011162 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 282459011163 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 282459011164 6 probable transmembrane helices predicted for SAS2266 by TMHMM2.0 at aa 9-31, 236-258, 271-293, 308-330, 335-352 and 391-413 282459011165 Pfam match to entry PF01061 ABC2_membrane, ABC-2 type transporter, score 19.5, E-value 3e-05 282459011166 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 282459011167 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 282459011168 Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 27.3, E-value 3.6e-05 282459011169 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 282459011170 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 282459011171 Cl binding site [ion binding]; other site 282459011172 oligomer interface [polypeptide binding]; other site 282459011173 Pfam match to entry PF01544 CorA, CorA-like Mg2+ transporter protein, score 56.3, E-value 6.8e-14 282459011174 2 probable transmembrane helices predicted for SAS2268 by TMHMM2.0 at aa 260-282 and 287-309 282459011175 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 282459011176 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282459011177 active site turn [active] 282459011178 phosphorylation site [posttranslational modification] 282459011179 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282459011180 8 probable transmembrane helices predicted for SAS2269 by TMHMM2.0 at aa 112-134, 154-176, 183-205, 264-286, 299-321, 347-369, 404-423 and 447-469 282459011181 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 266.1, E-value 4.9e-77 282459011182 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 67.1, E-value 4e-17 282459011183 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282459011184 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 282459011185 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 282459011186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 282459011187 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 34.3, E-value 3e-07 282459011188 Predicted helix-turn-helix motif for SAS2271 with score 1732.000, SD 5.09 at aa 164-185, sequence LSLKDIAMHCNISESYCSNLFV 282459011189 Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 35.7, E-value 1.1e-07 282459011190 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 282459011191 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 282459011192 Signal peptide predicted for SAS2273 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.435 between residues 34 and 35; signal peptide 282459011193 1 probable transmembrane helix predicted for SAS2273 by TMHMM2.0 at aa 7-29 282459011194 Signal peptide predicted for SAS2274 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.457 between residues 34 and 35; signal peptide 282459011195 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 282459011196 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 282459011197 Pfam match to entry PF00375 SDF, Sodium:dicarboxylate symporter family, score 556.6, E-value 1.8e-164 282459011198 8 probable transmembrane helices predicted for SAS2274 by TMHMM2.0 at aa 9-31, 46-68, 81-103, 159-176, 204-226, 231-253, 323-345 and 360-382 282459011199 PS00713 Sodium:dicarboxylate symporter family signature 1. 282459011200 Signal peptide predicted for SAS2275 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.701 between residues 32 and 33; signal peptide 282459011201 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 282459011202 1 probable transmembrane helix predicted for SAS2275 by TMHMM2.0 at aa 7-26 282459011203 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 282459011204 MarR family; Region: MarR_2; pfam12802 282459011205 Pfam match to entry PF01047 MarR, MarR family, score 63.5, E-value 4.8e-16 282459011206 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 282459011207 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 282459011208 Pfam match to entry PF00011 HSP20, Hsp20/alpha crystallin family, score 41.7, E-value 1.8e-09 282459011209 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 282459011210 Signal peptide predicted for SAS2278 by SignalP 2.0 HMM (Signal peptide probabilty 0.780) with cleavage site probability 0.457 between residues 36 and 37; signal peptide 282459011211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459011212 putative substrate translocation pore; other site 282459011213 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -109.8, E-value 0.0023 282459011214 12 probable transmembrane helices predicted for SAS2278 by TMHMM2.0 at aa 12-34, 44-63, 70-89, 99-121, 134-156, 161-180, 205-227, 242-259, 266-288, 292-314, 327-349 and 359-378 282459011215 Ortholog of S. aureus MRSA252 (BX571856) SAR2477; Similar to Bacillus subtilis hypothetical protein YjfC SWALL:O34458 (EMBL:AF015825) (309 aa) fasta scores: E(): 2.1e-21, 28.95% id in 297 aa. CDS contains a frameshift after codon 174;conserved hypothetical protein (pseudogene) 282459011216 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282459011217 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 282459011218 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 282459011219 DNA binding residues [nucleotide binding] 282459011220 dimer interface [polypeptide binding]; other site 282459011221 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 282459011222 Predicted helix-turn-helix motif for SAS2281 with score 1346.000, SD 3.77 at aa 5-26, sequence YTLKDIIEITGVTKRTLHYYDE 282459011223 Pfam match to entry PF00376 merR, MerR family regulatory protein, score 31.9, E-value 1.5e-06 282459011224 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 282459011225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459011226 active site 282459011227 phosphorylation site [posttranslational modification] 282459011228 intermolecular recognition site; other site 282459011229 dimerization interface [polypeptide binding]; other site 282459011230 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 282459011231 DNA binding residues [nucleotide binding] 282459011232 dimerization interface [polypeptide binding]; other site 282459011233 Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family, score 95.7, E-value 9.5e-26 282459011234 PS00622 Bacterial regulatory proteins, luxR family signature. 282459011235 Predicted helix-turn-helix motif for SAS2282 with score 1054.000, SD 2.78 at aa 170-191, sequence YGNKEIAEKLFVSVKTVEAHKT 282459011236 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 124.5, E-value 2.1e-34 282459011237 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 282459011238 Histidine kinase; Region: HisKA_3; pfam07730 282459011239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459011240 ATP binding site [chemical binding]; other site 282459011241 Mg2+ binding site [ion binding]; other site 282459011242 G-X-G motif; other site 282459011243 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 62.2, E-value 1.2e-15 282459011244 PS00430 TonB-dependent receptor proteins signature 1. 282459011245 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 282459011246 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 282459011247 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 282459011248 Pfam match to entry PF02665 Nitrate_red_gam, Nitrate reductase gamma subunit, score 266.8, E-value 3.1e-77 282459011249 5 probable transmembrane helices predicted for SAS2285 by TMHMM2.0 at aa 4-26, 47-69, 84-106, 126-148 and 186-208 282459011250 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 282459011251 Pfam match to entry PF02613 Nitrate_red_del, Nitrate reductase delta subunit, score 33.8, E-value 3.2e-09 282459011252 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 282459011253 PS00190 Cytochrome c family heme-binding site signature. 282459011254 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 282459011255 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 282459011256 [4Fe-4S] binding site [ion binding]; other site 282459011257 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 282459011258 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 282459011259 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 282459011260 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 282459011261 molybdopterin cofactor binding site; other site 282459011262 Pfam match to entry PF01568 Molydop_binding, Molydopterin dinucleotide binding domain, score 131.4, E-value 1.7e-36 282459011263 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 282459011264 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 282459011265 Pfam match to entry PF00384 molybdopterin, Molybdopterin oxidoreductase, score 432.3, E-value 4.4e-127 282459011266 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 282459011267 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 282459011268 active site 282459011269 SAM binding site [chemical binding]; other site 282459011270 homodimer interface [polypeptide binding]; other site 282459011271 PS00473 Gonadotropin-releasing hormones signature.; Pfam match to entry PF00446 GnRH, Gonadotropin-releasing hormone, score 10.1, E-value 0.064 282459011272 Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases, score 185.7, E-value 7.8e-53 282459011273 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 282459011274 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 282459011275 [2Fe-2S] cluster binding site [ion binding]; other site 282459011276 Pfam match to entry PF00355 Rieske, Rieske [2Fe-2S] domain, score 60.6, E-value 3.4e-15 282459011277 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 282459011278 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 282459011279 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 282459011280 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 282459011281 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 282459011282 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 282459011283 Pfam match to entry PF01077 NIR_SIR, Nitrite and sulphite reductase 4Fe-4S domain, score 87.1, E-value 3.8e-23 282459011284 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 282459011285 Pfam match to entry PF03460 NIR_SIR_ferr, Nitrite/Sulfite reductase ferredoxin-like half domain, score 68.2, E-value 1.8e-17 282459011286 Pfam match to entry PF04324 fer2_BFD, BFD-like [2Fe-2S] binding domain, score 26.6, E-value 6.2e-05 282459011287 Pfam match to entry PF04324 fer2_BFD, BFD-like [2Fe-2S] binding domain, score 94.7, E-value 2e-25 282459011288 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 255.9, E-value 5.5e-74 282459011289 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 282459011290 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 282459011291 putative active site [active] 282459011292 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 282459011293 active site 282459011294 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 282459011295 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459011296 Coenzyme A binding pocket [chemical binding]; other site 282459011297 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 282459011298 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 50.9, E-value 2.9e-12 282459011299 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 282459011300 Pfam match to entry PF01226 Form_Nir_trans, Formate/nitrite transporter, score 70.4, E-value 4e-18 282459011301 6 probable transmembrane helices predicted for SAS2294 by TMHMM2.0 at aa 38-60, 75-97, 117-139, 165-187, 200-222 and 242-264 282459011302 PS00146 Beta-lactamase class-A active site. 282459011303 2 probable transmembrane helices predicted for SAS2295 by TMHMM2.0 at aa 5-24 and 34-56 282459011304 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 282459011305 putative hydrophobic ligand binding site [chemical binding]; other site 282459011306 Pfam match to entry PF05146 DUF704, Aha1 domain, score 111.8, E-value 1.4e-30 282459011307 Signal peptide predicted for SAS2297 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.678 between residues 22 and 23; signal peptide 282459011308 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 282459011309 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 282459011310 intersubunit interface [polypeptide binding]; other site 282459011311 YodA lipocalin-like domain; Region: YodA; pfam09223 282459011312 Pfam match to entry PF01297 SBP_bac_9, Periplasmic solute binding protein family, score 217.0, E-value 3e-62 282459011313 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459011314 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 282459011315 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 282459011316 Pfam match to entry PF02604 DUF172, Uncharacterized ACR, COG2161, score 76.4, E-value 6.1e-20 282459011317 PS00017 ATP/GTP-binding site motif A (P-loop). 282459011318 Signal peptide predicted for SAS2300 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.933 between residues 25 and 26; signal peptide 282459011319 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 282459011320 Thioredoxin; Region: Thioredoxin_4; cl17273 282459011321 Pfam match to entry PF01323 DSBA, DSBA-like thioredoxin domain, score -7.4, E-value 0.00026 282459011322 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459011323 Signal peptide predicted for SAS2301 by SignalP 2.0 HMM (Signal peptide probabilty 0.964) with cleavage site probability 0.627 between residues 26 and 27; signal peptide 282459011324 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459011325 FemAB family; Region: FemAB; pfam02388 282459011326 Pfam match to entry PF02388 FemAB, FemAB family, score 748.9, E-value 2.2e-222 282459011327 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 282459011328 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 282459011329 Walker A/P-loop; other site 282459011330 ATP binding site [chemical binding]; other site 282459011331 Q-loop/lid; other site 282459011332 ABC transporter signature motif; other site 282459011333 Walker B; other site 282459011334 D-loop; other site 282459011335 H-loop/switch region; other site 282459011336 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 249.5, E-value 4.8e-72 282459011337 PS00211 ABC transporters family signature. 282459011338 PS00017 ATP/GTP-binding site motif A (P-loop). 282459011339 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 282459011340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459011341 dimer interface [polypeptide binding]; other site 282459011342 conserved gate region; other site 282459011343 putative PBP binding loops; other site 282459011344 ABC-ATPase subunit interface; other site 282459011345 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 97.3, E-value 3.2e-26 282459011346 4 probable transmembrane helices predicted for SAS2304 by TMHMM2.0 at aa 30-52, 65-87, 102-121 and 207-229 282459011347 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282459011348 Signal peptide predicted for SAS2305 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.371 between residues 24 and 25; signal peptide 282459011349 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 282459011350 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 282459011351 substrate binding pocket [chemical binding]; other site 282459011352 membrane-bound complex binding site; other site 282459011353 hinge residues; other site 282459011354 Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3, score 264.2, E-value 1.8e-76 282459011355 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459011356 Signal peptide predicted for SAS2306 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.571 between residues 30 and 31; signal peptide 282459011357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459011358 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282459011359 putative substrate translocation pore; other site 282459011360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459011361 14 probable transmembrane helices predicted for SAS2306 by TMHMM2.0 at aa 13-35, 45-67, 74-96, 100-122, 134-156, 161-180, 192-214, 224-242, 262-284, 299-321, 328-346, 351-373, 394-416 and 444-466 282459011362 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 282459011363 catalytic core [active] 282459011364 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 282459011365 Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family, score 345.5, E-value 6e-101 282459011366 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 282459011367 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 282459011368 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 282459011369 Pfam match to entry PF01545 Cation_efflux, Cation efflux family, score 318.8, E-value 6.8e-93 282459011370 5 probable transmembrane helices predicted for SAS2308 by TMHMM2.0 at aa 13-35, 39-61, 82-101, 116-135 and 174-196 282459011371 Signal peptide predicted for SAS2309 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.965 between residues 29 and 30; signal peptide 282459011372 B domain; Region: B; pfam02216 282459011373 B domain; Region: B; pfam02216 282459011374 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 282459011375 Pfam match to entry PF02216 B, B domain, score 121.4, E-value 1.8e-33 282459011376 Pfam match to entry PF02216 B, B domain, score 117.1, E-value 3.6e-32 282459011377 Signal peptide predicted for SAS2310 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.976 between residues 29 and 30; signal peptide 282459011378 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 282459011379 Pfam match to entry PF01117 Aerolysin, Aerolysin/Hemolysin/Leukocidin toxin, score 347.2, E-value 1.9e-101 282459011380 Signal peptide predicted for SAS2311 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.984 between residues 29 and 30; signal peptide 282459011381 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 282459011382 Pfam match to entry PF01117 Aerolysin, Aerolysin/Hemolysin/Leukocidin toxin, score 349.6, E-value 3.7e-102 282459011383 Signal peptide predicted for SAS2312 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.707 between residues 26 and 27; signal peptide 282459011384 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 282459011385 Pfam match to entry PF01117 Aerolysin, Aerolysin/Hemolysin/Leukocidin toxin, score 361.2, E-value 1.1e-105 282459011386 Signal peptide predicted for SAS2313 by SignalP 2.0 HMM (Signal peptide probabilty 0.634) with cleavage site probability 0.357 between residues 39 and 40; signal peptide 282459011387 4 probable transmembrane helices predicted for SAS2313 by TMHMM2.0 at aa 9-31, 53-75, 82-104 and 124-146 282459011388 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 282459011389 Pfam match to entry PF03744 BioW, 6-carboxyhexanoate--CoA ligase, score 116.8, E-value 4.1e-32 282459011390 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 282459011391 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 282459011392 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 282459011393 catalytic residue [active] 282459011394 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class I and II, score 15.6, E-value 1.5e-06 282459011395 biotin synthase; Validated; Region: PRK06256 282459011396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282459011397 FeS/SAM binding site; other site 282459011398 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 282459011399 Pfam match to entry PF04055 Radical_SAM, Radical SAM superfamily, score 85.7, E-value 9.8e-23 282459011400 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 282459011401 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 282459011402 inhibitor-cofactor binding pocket; inhibition site 282459011403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459011404 catalytic residue [active] 282459011405 Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III, score 470.7, E-value 1.2e-138 282459011406 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 282459011407 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 282459011408 AAA domain; Region: AAA_26; pfam13500 282459011409 Signal peptide predicted for SAS2319 by SignalP 2.0 HMM (Signal peptide probabilty 0.888) with cleavage site probability 0.462 between residues 40 and 41; signal peptide 282459011410 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 282459011411 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 282459011412 Walker A/P-loop; other site 282459011413 ATP binding site [chemical binding]; other site 282459011414 Q-loop/lid; other site 282459011415 ABC transporter signature motif; other site 282459011416 Walker B; other site 282459011417 D-loop; other site 282459011418 H-loop/switch region; other site 282459011419 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 210.2, E-value 3.3e-60 282459011420 PS00211 ABC transporters family signature. 282459011421 PS00017 ATP/GTP-binding site motif A (P-loop). 282459011422 Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region, score 19.8, E-value 0.00023 282459011423 5 probable transmembrane helices predicted for SAS2319 by TMHMM2.0 at aa 21-43, 58-80, 140-157, 161-179 and 242-264 282459011424 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 282459011425 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 282459011426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282459011427 Walker A/P-loop; other site 282459011428 ATP binding site [chemical binding]; other site 282459011429 Q-loop/lid; other site 282459011430 ABC transporter signature motif; other site 282459011431 Walker B; other site 282459011432 D-loop; other site 282459011433 H-loop/switch region; other site 282459011434 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 201.2, E-value 1.6e-57 282459011435 PS00211 ABC transporters family signature. 282459011436 PS00017 ATP/GTP-binding site motif A (P-loop). 282459011437 Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region, score 84.2, E-value 2.8e-22 282459011438 4 probable transmembrane helices predicted for SAS2320 by TMHMM2.0 at aa 29-51, 58-80, 144-166 and 257-279 282459011439 Predicted membrane protein [Function unknown]; Region: COG2246 282459011440 GtrA-like protein; Region: GtrA; pfam04138 282459011441 Pfam match to entry PF04138 GtrA, GtrA-like protein, score 145.7, E-value 8.5e-41 282459011442 4 probable transmembrane helices predicted for SAS2323 by TMHMM2.0 at aa 13-35, 40-62, 75-97 and 102-124 282459011443 glycerate kinase; Region: TIGR00045 282459011444 Pfam match to entry PF02595 Gly_kinase, Glycerate kinase family, score 552.3, E-value 3.4e-163 282459011445 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 282459011446 1 probable transmembrane helix predicted for SAS2325 by TMHMM2.0 at aa 70-92 282459011447 Signal peptide predicted for SAS2326 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.601 between residues 42 and 43; signal peptide 282459011448 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 282459011449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459011450 putative substrate translocation pore; other site 282459011451 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -71.8, E-value 0.00014 282459011452 12 probable transmembrane helices predicted for SAS2326 by TMHMM2.0 at aa 13-35, 50-72, 81-100, 105-127, 139-161, 165-187, 217-239, 254-276, 283-305, 309-331, 343-365 and 375-394 282459011453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 282459011454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 282459011455 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459011456 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 282459011457 putative phosphoesterase; Region: acc_ester; TIGR03729 282459011458 Pfam match to entry PF00149 Metallophos, Calcineurin-like phosphoesterase, score 55.0, E-value 1.7e-13 282459011459 Signal peptide predicted for SAS2330 by SignalP 2.0 HMM (Signal peptide probabilty 0.914) with cleavage site probability 0.476 between residues 37 and 38; signal peptide 282459011460 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 282459011461 Spore germination protein; Region: Spore_permease; cl17796 282459011462 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score 412.0, E-value 5.8e-121 282459011463 12 probable transmembrane helices predicted for SAS2330 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 122-144, 149-171, 191-213, 234-256, 271-293, 328-350, 360-382, 403-420 and 425-442 282459011464 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 282459011465 12 probable transmembrane helices predicted for SAS2331 by TMHMM2.0 at aa 4-21, 28-45, 55-72, 84-106, 110-132, 152-174, 184-206, 230-252, 280-302, 309-331, 366-388 and 401-423 282459011466 Pfam match to entry PF00999 Na_H_Exchanger, Sodium/hydrogen exchanger family, score 179.2, E-value 7e-51 282459011467 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 282459011468 11 probable transmembrane helices predicted for SAS2332 by TMHMM2.0 at aa 58-80, 106-128, 138-160, 172-194, 209-231, 252-274, 302-324, 345-367, 372-394, 407-426 and 430-447 282459011469 PS00589 PTS HPR component serine phosphorylation site signature. 282459011470 PS00012 Phosphopantetheine attachment site. 282459011471 Signal peptide predicted for SAS2333 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.958 between residues 29 and 30; signal peptide 282459011472 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 282459011473 Beta-lactamase; Region: Beta-lactamase; pfam00144 282459011474 4 probable transmembrane helices predicted for SAS2333 by TMHMM2.0 at aa 7-26, 389-408, 429-451 and 471-493 282459011475 Pfam match to entry PF00144 beta-lactamase, Beta-lactamase, score 268.5, E-value 9e-78 282459011476 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 282459011477 extended (e) SDRs; Region: SDR_e; cd08946 282459011478 NAD(P) binding site [chemical binding]; other site 282459011479 active site 282459011480 substrate binding site [chemical binding]; other site 282459011481 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 282459011482 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 282459011483 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 282459011484 Pfam match to entry PF02558 ApbA, Ketopantoate reductase PanE/ApbA, score 89.9, E-value 5.4e-24 282459011485 Signal peptide predicted for SAS2336 by SignalP 2.0 HMM (Signal peptide probabilty 0.910) with cleavage site probability 0.436 between residues 43 and 44; signal peptide 282459011486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459011487 putative substrate translocation pore; other site 282459011488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459011489 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -83.7, E-value 0.00034 282459011490 14 probable transmembrane helices predicted for SAS2336 by TMHMM2.0 at aa 13-31, 46-68, 81-103, 108-130, 137-159, 163-185, 206-224, 229-251, 271-293, 308-326, 339-358, 362-381, 411-433 and 437-459 282459011491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459011492 dimer interface [polypeptide binding]; other site 282459011493 conserved gate region; other site 282459011494 ABC-ATPase subunit interface; other site 282459011495 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 101.9, E-value 1.3e-27 282459011496 5 probable transmembrane helices predicted for SAS2337 by TMHMM2.0 at aa 27-49, 56-78, 88-110, 138-160 and 185-207 282459011497 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 282459011498 Signal peptide predicted for SAS2338 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.338 between residues 28 and 29; signal peptide 282459011499 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 282459011500 Pfam match to entry PF04069 OpuAC, Substrate binding domain of ABC-type glycine betaine transport system, score 373.7, E-value 2e-109 282459011501 1 probable transmembrane helix predicted for SAS2338 by TMHMM2.0 at aa 7-26 282459011502 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459011503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459011504 dimer interface [polypeptide binding]; other site 282459011505 conserved gate region; other site 282459011506 putative PBP binding loops; other site 282459011507 ABC-ATPase subunit interface; other site 282459011508 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 95.0, E-value 1.6e-25 282459011509 5 probable transmembrane helices predicted for SAS2339 by TMHMM2.0 at aa 20-42, 49-71, 81-100, 144-166 and 176-198 282459011510 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282459011511 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 282459011512 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 282459011513 Walker A/P-loop; other site 282459011514 ATP binding site [chemical binding]; other site 282459011515 Q-loop/lid; other site 282459011516 ABC transporter signature motif; other site 282459011517 Walker B; other site 282459011518 D-loop; other site 282459011519 H-loop/switch region; other site 282459011520 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 282459011521 Pfam match to entry PF00571 CBS, CBS domain, score 46.9, E-value 4.8e-11 282459011522 Pfam match to entry PF00571 CBS, CBS domain, score 45.2, E-value 1.6e-10 282459011523 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 226.1, E-value 5.4e-65 282459011524 PS00211 ABC transporters family signature. 282459011525 PS00017 ATP/GTP-binding site motif A (P-loop). 282459011526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 282459011527 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 282459011528 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 282459011529 Signal peptide predicted for SAS2342 by SignalP 2.0 HMM (Signal peptide probabilty 0.893) with cleavage site probability 0.286 between residues 36 and 37; signal peptide 282459011530 amino acid transporter; Region: 2A0306; TIGR00909 282459011531 14 probable transmembrane helices predicted for SAS2342 by TMHMM2.0 at aa 12-34, 44-66, 87-109, 134-156, 163-185, 200-222, 242-264, 298-320, 345-367, 372-394, 407-429, 433-450, 463-484 and 499-521 282459011532 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score 35.5, E-value 5.2e-09 282459011533 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 282459011534 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 282459011535 substrate binding pocket [chemical binding]; other site 282459011536 catalytic triad [active] 282459011537 Pfam match to entry PF00135 COesterase, Carboxylesterase, score 145.8, E-value 7.9e-41 282459011538 PS00941 Carboxylesterases type-B signature 2. 282459011539 PS00122 Carboxylesterases type-B serine active site. 282459011540 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 282459011541 Signal peptide predicted for SAS2344 by SignalP 2.0 HMM (Signal peptide probabilty 0.710) with cleavage site probability 0.318 between residues 36 and 37; signal peptide 282459011542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459011543 putative substrate translocation pore; other site 282459011544 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -77.2, E-value 0.00021 282459011545 10 probable transmembrane helices predicted for SAS2344 by TMHMM2.0 at aa 7-29, 39-60, 73-95, 100-122, 129-151, 155-177, 214-236, 246-268, 281-303 and 364-383 282459011546 PS00215 Mitochondrial energy transfer proteins signature. 282459011547 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 282459011548 Signal peptide predicted for SAS2345 by SignalP 2.0 HMM (Signal peptide probabilty 0.770) with cleavage site probability 0.493 between residues 22 and 23; signal peptide 282459011549 Pfam match to entry PF03649 UPF0014, Uncharacterised protein family (UPF0014), score 204.3, E-value 1.9e-58 282459011550 6 probable transmembrane helices predicted for SAS2345 by TMHMM2.0 at aa 2-21, 31-53, 60-77, 87-109, 189-211 and 216-238 282459011551 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 282459011552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282459011553 Walker A/P-loop; other site 282459011554 ATP binding site [chemical binding]; other site 282459011555 Q-loop/lid; other site 282459011556 ABC transporter signature motif; other site 282459011557 Walker B; other site 282459011558 D-loop; other site 282459011559 H-loop/switch region; other site 282459011560 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 162.0, E-value 1e-45 282459011561 PS00211 ABC transporters family signature. 282459011562 PS00017 ATP/GTP-binding site motif A (P-loop). 282459011563 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 282459011564 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 282459011565 oligomer interface [polypeptide binding]; other site 282459011566 active site 282459011567 metal binding site [ion binding]; metal-binding site 282459011568 Pfam match to entry PF05343 Peptidase_M42, M42 glutamyl aminopeptidase, score 608.9, E-value 3.2e-180 282459011569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 282459011570 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 282459011571 Pfam match to entry PF02604 DUF172, Uncharacterized ACR, COG2161, score 26.3, E-value 3e-05 282459011572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 282459011573 Signal peptide predicted for SAS2350 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.587 between residues 22 and 23; signal peptide 282459011574 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459011575 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 282459011576 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 282459011577 active site 282459011578 FMN binding site [chemical binding]; other site 282459011579 substrate binding site [chemical binding]; other site 282459011580 3Fe-4S cluster binding site [ion binding]; other site 282459011581 Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase, score 391.2, E-value 1e-114 282459011582 1 probable transmembrane helix predicted for SAS2351 by TMHMM2.0 at aa 9-31 282459011583 6 probable transmembrane helices predicted for SAS2352 by TMHMM2.0 at aa 27-49, 59-81, 106-128, 148-170, 182-204 and 231-248 282459011584 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 282459011585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459011586 Major Facilitator Superfamily; Region: MFS_1; pfam07690 282459011587 putative substrate translocation pore; other site 282459011588 12 probable transmembrane helices predicted for SAS2353 by TMHMM2.0 at aa 7-29, 39-61, 74-93, 98-120, 132-154, 159-178, 214-236, 241-263, 283-305, 309-331, 338-360 and 364-386 282459011589 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 282459011590 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282459011591 Walker A/P-loop; other site 282459011592 ATP binding site [chemical binding]; other site 282459011593 Q-loop/lid; other site 282459011594 ABC transporter signature motif; other site 282459011595 Walker B; other site 282459011596 D-loop; other site 282459011597 H-loop/switch region; other site 282459011598 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 201.4, E-value 1.5e-57 282459011599 PS00211 ABC transporters family signature. 282459011600 PS00017 ATP/GTP-binding site motif A (P-loop). 282459011601 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 282459011602 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 282459011603 Walker A/P-loop; other site 282459011604 ATP binding site [chemical binding]; other site 282459011605 Q-loop/lid; other site 282459011606 ABC transporter signature motif; other site 282459011607 Walker B; other site 282459011608 D-loop; other site 282459011609 H-loop/switch region; other site 282459011610 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 282459011611 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 171.3, E-value 1.7e-48 282459011612 PS00211 ABC transporters family signature. 282459011613 PS00017 ATP/GTP-binding site motif A (P-loop). 282459011614 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 282459011615 Signal peptide predicted for SAS2356 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.739 between residues 36 and 37; signal peptide 282459011616 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 282459011617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459011618 dimer interface [polypeptide binding]; other site 282459011619 conserved gate region; other site 282459011620 putative PBP binding loops; other site 282459011621 ABC-ATPase subunit interface; other site 282459011622 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 137.3, E-value 3e-38 282459011623 5 probable transmembrane helices predicted for SAS2356 by TMHMM2.0 at aa 13-35, 79-101, 122-144, 194-216 and 236-258 282459011624 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 282459011625 Signal peptide predicted for SAS2357 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.951 between residues 41 and 42; signal peptide 282459011626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 282459011627 dimer interface [polypeptide binding]; other site 282459011628 conserved gate region; other site 282459011629 putative PBP binding loops; other site 282459011630 ABC-ATPase subunit interface; other site 282459011631 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport system inner membrane component, score 217.7, E-value 1.9e-62 282459011632 6 probable transmembrane helices predicted for SAS2357 by TMHMM2.0 at aa 9-31, 107-126, 139-161, 176-193, 234-256 and 276-298 282459011633 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 282459011634 Signal peptide predicted for SAS2358 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.567 between residues 28 and 29; signal peptide 282459011635 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 282459011636 substrate binding site [chemical binding]; other site 282459011637 Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 240.3, E-value 2.8e-69 282459011638 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 282459011639 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459011640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 282459011641 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 282459011642 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 282459011643 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 282459011644 short chain dehydrogenase; Validated; Region: PRK08589 282459011645 Signal peptide predicted for SAS2363 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.649 between residues 27 and 28; signal peptide 282459011646 classical (c) SDRs; Region: SDR_c; cd05233 282459011647 NAD(P) binding site [chemical binding]; other site 282459011648 active site 282459011649 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 274.6, E-value 1.3e-79 282459011650 PS00061 Short-chain dehydrogenases/reductases family signature. 282459011651 AbgT putative transporter family; Region: ABG_transport; cl17431 282459011652 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 282459011653 Pfam match to entry PF03806 ABG_transport, AbgT transporter family, score 1123.2, E-value 0 282459011654 12 probable transmembrane helices predicted for SAS2364 by TMHMM2.0 at aa 32-54, 85-104, 124-157, 164-186, 215-237, 269-291, 306-328, 341-363, 388-407, 414-433, 443-462 and 482-504 282459011655 PS00019 Actinin-type actin-binding domain signature 1. 282459011656 Uncharacterized conserved protein [Function unknown]; Region: COG2128 282459011657 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 282459011658 Signal peptide predicted for SAS2366 by SignalP 2.0 HMM (Signal peptide probabilty 0.844) with cleavage site probability 0.552 between residues 22 and 23; signal peptide 282459011659 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 282459011660 1 probable transmembrane helix predicted for SAS2366 by TMHMM2.0 at aa 6-25 282459011661 Signal peptide predicted for SAS2367 by SignalP 2.0 HMM (Signal peptide probabilty 0.959) with cleavage site probability 0.555 between residues 29 and 30; signal peptide 282459011662 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 282459011663 1 probable transmembrane helix predicted for SAS2367 by TMHMM2.0 at aa 5-27 282459011664 Signal peptide predicted for SAS2368 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.684 between residues 21 and 22; signal peptide 282459011665 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 282459011666 1 probable transmembrane helix predicted for SAS2368 by TMHMM2.0 at aa 6-25 282459011667 Signal peptide predicted for SAS2369 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.610 between residues 29 and 30; signal peptide 282459011668 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 282459011669 1 probable transmembrane helix predicted for SAS2369 by TMHMM2.0 at aa 5-27 282459011670 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 282459011671 classical (c) SDRs; Region: SDR_c; cd05233 282459011672 NAD(P) binding site [chemical binding]; other site 282459011673 active site 282459011674 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 227.4, E-value 2.1e-65 282459011675 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 282459011676 Signal peptide predicted for SAS2373 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.763 between residues 30 and 31; signal peptide 282459011677 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282459011678 Pfam match to entry PF04507 DUF576, Protein of unknown function, DUF576, score 620.7, E-value 8.9e-184 282459011679 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459011680 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282459011681 Signal peptide predicted for SAS2374 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.496 between residues 30 and 31; signal peptide 282459011682 Pfam match to entry PF04507 DUF576, Protein of unknown function, DUF576, score 589.1, E-value 2.9e-174 282459011683 1 probable transmembrane helix predicted for SAS2374 by TMHMM2.0 at aa 7-26 282459011684 Signal peptide predicted for SAS2375 by SignalP 2.0 HMM (Signal peptide probabilty 0.756) with cleavage site probability 0.257 between residues 25 and 26; signal peptide 282459011685 Protein of unknown function, DUF576; Region: DUF576; pfam04507 282459011686 Pfam match to entry PF04507 DUF576, Protein of unknown function, DUF576, score 608.7, E-value 3.7e-180 282459011687 1 probable transmembrane helix predicted for SAS2375 by TMHMM2.0 at aa 7-26 282459011688 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459011689 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 282459011690 PLD-like domain; Region: PLDc_2; pfam13091 282459011691 putative homodimer interface [polypeptide binding]; other site 282459011692 putative active site [active] 282459011693 catalytic site [active] 282459011694 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 282459011695 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 282459011696 ATP binding site [chemical binding]; other site 282459011697 putative Mg++ binding site [ion binding]; other site 282459011698 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 282459011699 nucleotide binding region [chemical binding]; other site 282459011700 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 282459011701 ATP-binding site [chemical binding]; other site 282459011702 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 282459011703 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain, score 65.3, E-value 1.3e-16 282459011704 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 282459011705 active site 282459011706 8-oxo-dGMP binding site [chemical binding]; other site 282459011707 nudix motif; other site 282459011708 metal binding site [ion binding]; metal-binding site 282459011709 Pfam match to entry PF00293 NUDIX, NUDIX domain, score 68.8, E-value 1.2e-17 282459011710 PS00893 mutT domain signature. 282459011711 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 282459011712 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 282459011713 active site 282459011714 substrate binding site [chemical binding]; other site 282459011715 metal binding site [ion binding]; metal-binding site 282459011716 Pfam match to entry PF02878 PGM_PMM_I, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I, score 196.5, E-value 4.4e-56 282459011717 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 282459011718 Pfam match to entry PF02879 PGM_PMM_II, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II, score 19.9, E-value 1.7e-05 282459011719 Pfam match to entry PF02880 PGM_PMM_III, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III, score -6.4, E-value 0.11 282459011720 Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase, C-terminal domain, score 15.3, E-value 0.00024 282459011721 Signal peptide predicted for SAS2379 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.643 between residues 28 and 29; signal peptide 282459011722 1 probable transmembrane helix predicted for SAS2379 by TMHMM2.0 at aa 7-29 282459011723 3 probable transmembrane helices predicted for SAS2380 by TMHMM2.0 at aa 5-24, 47-69 and 74-96 282459011724 2 probable transmembrane helices predicted for SAS2381 by TMHMM2.0 at aa 26-48 and 52-71 282459011725 H+ Antiporter protein; Region: 2A0121; TIGR00900 282459011726 8 probable transmembrane helices predicted for SAS2382 by TMHMM2.0 at aa 20-38, 48-70, 77-99, 156-190, 219-241, 256-278, 290-312 and 365-387 282459011727 Signal peptide predicted for SAS2383 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.981 between residues 50 and 51; signal peptide 282459011728 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282459011729 G5 domain; Region: G5; pfam07501 282459011730 G5 domain; Region: G5; pfam07501 282459011731 G5 domain; Region: G5; pfam07501 282459011732 G5 domain; Region: G5; pfam07501 282459011733 G5 domain; Region: G5; pfam07501 282459011734 G5 domain; Region: G5; pfam07501 282459011735 G5 domain; Region: G5; pfam07501 282459011736 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 282459011737 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 35.7, E-value 1.1e-07 282459011738 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282459011739 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 50.2, E-value 4.8e-12 282459011740 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282459011741 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 282459011742 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282459011743 Transcriptional regulators [Transcription]; Region: MarR; COG1846 282459011744 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 282459011745 Signal peptide predicted for SAS2386 by SignalP 2.0 HMM (Signal peptide probabilty 0.787) with cleavage site probability 0.730 between residues 24 and 25; signal peptide 282459011746 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 282459011747 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 282459011748 active site 282459011749 tetramer interface; other site 282459011750 Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase, score 52.8, E-value 2.4e-14 282459011751 Signal peptide predicted for SAS2387 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.472 between residues 37 and 38; signal peptide 282459011752 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282459011753 Mucin-like glycoprotein; Region: Mucin; pfam01456 282459011754 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 282459011755 Fibronectin binding repeat; Region: Fn_bind; pfam02986 282459011756 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 38.5, E-value 1.6e-08 282459011757 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282459011758 Pfam match to entry PF02986 Fn_bind, Fibronectin binding repeat, score 15.8, E-value 0.011 282459011759 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 39.0, E-value 1.1e-08 282459011760 Signal peptide predicted for SAS2388 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.554 between residues 37 and 38; signal peptide 282459011761 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282459011762 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 282459011763 Fibronectin binding repeat; Region: Fn_bind; pfam02986 282459011764 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 282459011765 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 39.2, E-value 1e-08 282459011766 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282459011767 Pfam match to entry PF02986 Fn_bind, Fibronectin binding repeat, score 15.7, E-value 0.011 282459011768 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 39.4, E-value 8.6e-09 282459011769 GntP family permease; Region: GntP_permease; pfam02447 282459011770 fructuronate transporter; Provisional; Region: PRK10034; cl15264 282459011771 Pfam match to entry PF02447 GntP_permease, GntP family permease, score 831.1, E-value 3.9e-247 282459011772 12 probable transmembrane helices predicted for SAS2390 by TMHMM2.0 at aa 5-24, 29-51, 63-85, 105-127, 140-159, 179-201, 232-254, 269-288, 309-331, 351-373, 385-407 and 427-449 282459011773 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 282459011774 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 282459011775 N- and C-terminal domain interface [polypeptide binding]; other site 282459011776 active site 282459011777 catalytic site [active] 282459011778 metal binding site [ion binding]; metal-binding site 282459011779 carbohydrate binding site [chemical binding]; other site 282459011780 ATP binding site [chemical binding]; other site 282459011781 Pfam match to entry PF02782 FGGY_C, FGGY family of carbohydrate kinases, C-terminal domain, score 294.8, E-value 1.1e-85 282459011782 PS00445 FGGY family of carbohydrate kinases signature 2. 282459011783 Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases, N-terminal domain, score 284.4, E-value 1.5e-82 282459011784 Transcriptional regulators [Transcription]; Region: GntR; COG1802 282459011785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 282459011786 DNA-binding site [nucleotide binding]; DNA binding site 282459011787 FCD domain; Region: FCD; pfam07729 282459011788 Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 56.6, E-value 5.6e-14 282459011789 PS00043 Bacterial regulatory proteins, gntR family signature. 282459011790 Predicted helix-turn-helix motif for SAS2392 with score 1508.000, SD 4.32 at aa 38-59, sequence LTENQMAKQFNVSRSPIRDAFK 282459011791 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 282459011792 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 282459011793 DNA binding residues [nucleotide binding] 282459011794 2 probable transmembrane helices predicted for SAS2393 by TMHMM2.0 at aa 141-163 and 168-187 282459011795 Pfam match to entry PF00376 merR, MerR family regulatory protein, score 44.4, E-value 2.6e-10 282459011796 Predicted helix-turn-helix motif for SAS2393 with score 1686.000, SD 4.93 at aa 4-25, sequence YSTGELAKLCNVTTRTIQYYDR 282459011797 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 282459011798 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 282459011799 synthetase active site [active] 282459011800 NTP binding site [chemical binding]; other site 282459011801 metal binding site [ion binding]; metal-binding site 282459011802 Pfam match to entry PF04607 RelA_SpoT, Region found in RelA / SpoT proteins, score 206.7, E-value 3.8e-59 282459011803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 282459011804 Predicted membrane protein [Function unknown]; Region: COG1289 282459011805 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 282459011806 Pfam match to entry PF05976 DUF893, Bacterial membrane protein of unknown function (DUF893), score -343.3, E-value 0.0015 282459011807 9 probable transmembrane helices predicted for SAS2396 by TMHMM2.0 at aa 7-29, 39-58, 65-87, 113-135, 305-327, 332-351, 364-386, 401-420 and 427-449 282459011808 2 probable transmembrane helices predicted for SAS2396a by TMHMM2.0 at aa 12-34 and 39-61 282459011809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 282459011810 D-galactonate transporter; Region: 2A0114; TIGR00893 282459011811 putative substrate translocation pore; other site 282459011812 Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter, score -107.4, E-value 0.0019 282459011813 11 probable transmembrane helices predicted for SAS2397 by TMHMM2.0 at aa 7-25, 48-70, 83-105, 140-162, 167-186, 227-249, 270-292, 297-319, 326-348, 363-385 and 392-409 282459011814 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 282459011815 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 282459011816 5 probable transmembrane helices predicted for SAS2398 by TMHMM2.0 at aa 13-35, 50-72, 108-127, 137-159 and 179-196 282459011817 Pfam match to entry PF00597 DedA, DedA family, score 29.3, E-value 9.1e-06 282459011818 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 282459011819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282459011820 Walker A/P-loop; other site 282459011821 ATP binding site [chemical binding]; other site 282459011822 Q-loop/lid; other site 282459011823 ABC transporter signature motif; other site 282459011824 Walker B; other site 282459011825 D-loop; other site 282459011826 H-loop/switch region; other site 282459011827 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 157.8, E-value 2e-44 282459011828 PS00017 ATP/GTP-binding site motif A (P-loop). 282459011829 PS00211 ABC transporters family signature. 282459011830 Signal peptide predicted for SAS2400 by SignalP 2.0 HMM (Signal peptide probabilty 0.881) with cleavage site probability 0.631 between residues 33 and 34; signal peptide 282459011831 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 282459011832 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 282459011833 6 probable transmembrane helices predicted for SAS2400 by TMHMM2.0 at aa 17-36, 56-78, 98-120, 144-166, 173-195 and 229-251 282459011834 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 282459011835 similar to hypothetical protein; Doubtful CDS 282459011836 Signal peptide predicted for SAS2402 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.379 between residues 26 and 27; signal peptide 282459011837 Uncharacterized membrane protein [Function unknown]; Region: COG3949 282459011838 10 probable transmembrane helices predicted for SAS2402 by TMHMM2.0 at aa 7-26, 36-58, 78-100, 115-134, 139-161, 187-209, 221-243, 267-289, 302-324 and 328-345 282459011839 Predicted esterase [General function prediction only]; Region: COG0400 282459011840 putative hydrolase; Provisional; Region: PRK11460 282459011841 Pfam match to entry PF02230 abhydrolase_2, Phospholipase/Carboxylesterase, score -16.7, E-value 7.6e-07 282459011842 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 282459011843 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 282459011844 Zn binding site [ion binding]; other site 282459011845 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 282459011846 Zn binding site [ion binding]; other site 282459011847 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 54.9, E-value 1.8e-13 282459011848 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 282459011849 MarR family; Region: MarR; pfam01047 282459011850 Pfam match to entry PF01047 MarR, MarR family, score 101.6, E-value 1.6e-27 282459011851 Predicted acetyltransferase [General function prediction only]; Region: COG2388 282459011852 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 21.7, E-value 8.2e-07 282459011853 Ortholog of S. aureus MRSA252 (BX571856) SAR2602; Similar to Bacillus halodurans hypothetical protein BH3305 SWALL:Q9K7Q6 (EMBL:AP001518) (286 aa) fasta scores: E(): 3e-31, 39.91% id in 243 aa. CDS contains a frameshift after codon 105;glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein (pseudogene) 282459011854 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 40.9, E-value 3.1e-09 282459011855 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 282459011856 dimer interface [polypeptide binding]; other site 282459011857 FMN binding site [chemical binding]; other site 282459011858 Pfam match to entry PF00881 Nitroreductase, Nitroreductase family, score 176.6, E-value 4.4e-50 282459011859 D-lactate dehydrogenase; Provisional; Region: PRK12480 282459011860 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 282459011861 homodimer interface [polypeptide binding]; other site 282459011862 ligand binding site [chemical binding]; other site 282459011863 NAD binding site [chemical binding]; other site 282459011864 catalytic site [active] 282459011865 Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 94.6, E-value 2.1e-25 282459011866 Pfam match to entry PF02826 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 236.0, E-value 5.7e-68 282459011867 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 282459011868 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 282459011869 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 282459011870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 282459011871 active site 282459011872 motif I; other site 282459011873 motif II; other site 282459011874 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 7.4, E-value 0.0071 282459011875 PS01229 Hypothetical cof family signature 2. 282459011876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 282459011877 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 282459011878 Walker A/P-loop; other site 282459011879 ATP binding site [chemical binding]; other site 282459011880 Q-loop/lid; other site 282459011881 ABC transporter signature motif; other site 282459011882 Walker B; other site 282459011883 D-loop; other site 282459011884 H-loop/switch region; other site 282459011885 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 41.3, E-value 2.3e-09 282459011886 PS00017 ATP/GTP-binding site motif A (P-loop). 282459011887 Signal peptide predicted for SAS2413 by SignalP 2.0 HMM (Signal peptide probabilty 0.775) with cleavage site probability 0.565 between residues 43 and 44; signal peptide 282459011888 6 probable transmembrane helices predicted for SAS2413 by TMHMM2.0 at aa 16-38, 51-73, 100-122, 127-149, 156-176 and 211-233 282459011889 Signal peptide predicted for SAS2414 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.743 between residues 25 and 26; signal peptide 282459011890 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 282459011891 active site 282459011892 catalytic site [active] 282459011893 Pfam match to entry PF04203 Sortase, Sortase family, score 195.1, E-value 1.2e-55 282459011894 1 probable transmembrane helix predicted for SAS2414 by TMHMM2.0 at aa 7-24 282459011895 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 282459011896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459011897 Coenzyme A binding pocket [chemical binding]; other site 282459011898 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 81.1, E-value 2.3e-21 282459011899 2 probable transmembrane helices predicted for SAS2415a by TMHMM2.0 at aa 5-22 and 26-48 282459011900 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 282459011901 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 282459011902 Pfam match to entry PF03313 SDH_alpha, Serine dehydratase alpha chain, score 401.5, E-value 8.3e-118 282459011903 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 282459011904 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 282459011905 Pfam match to entry PF03315 SDH_beta, Serine dehydratase beta chain, score 133.0, E-value 5.7e-37 282459011906 Signal peptide predicted for SAS2418 by SignalP 2.0 HMM (Signal peptide probabilty 0.731) with cleavage site probability 0.408 between residues 23 and 24; signal peptide 282459011907 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 282459011908 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 282459011909 9 probable transmembrane helices predicted for SAS2418 by TMHMM2.0 at aa 4-21, 34-56, 76-98, 103-120, 130-152, 173-195, 205-224, 256-278 and 303-325 282459011910 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 24.7, E-value 5.6e-07 282459011911 1 probable transmembrane helix predicted for SAS2419 by TMHMM2.0 at aa 13-35 282459011912 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 282459011913 EamA-like transporter family; Region: EamA; pfam00892 282459011914 EamA-like transporter family; Region: EamA; pfam00892 282459011915 10 probable transmembrane helices predicted for SAS2420 by TMHMM2.0 at aa 7-29, 39-58, 79-101, 106-125, 132-154, 159-181, 186-208, 223-245, 258-277 and 282-299 282459011916 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6, score 60.2, E-value 4.6e-15 282459011917 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6, score 78.9, E-value 1.1e-20 282459011918 Signal peptide predicted for SAS2421 by SignalP 2.0 HMM (Signal peptide probabilty 0.815) with cleavage site probability 0.555 between residues 18 and 19; signal peptide 282459011919 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 282459011920 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 282459011921 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 282459011922 catalytic residues [active] 282459011923 PS00190 Cytochrome c family heme-binding site signature. 282459011924 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 282459011925 active site 282459011926 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 282459011927 Signal peptide predicted for SAS2424 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.446 between residues 35 and 36; signal peptide 282459011928 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 282459011929 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 282459011930 active site turn [active] 282459011931 phosphorylation site [posttranslational modification] 282459011932 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 282459011933 HPr interaction site; other site 282459011934 glycerol kinase (GK) interaction site [polypeptide binding]; other site 282459011935 active site 282459011936 phosphorylation site [posttranslational modification] 282459011937 Pfam match to entry PF00358 PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1, score 209.9, E-value 4e-60 282459011938 PS00371 PTS EIIA domains phosphorylation site signature 1. 282459011939 Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB, score 66.7, E-value 5.2e-17 282459011940 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 282459011941 9 probable transmembrane helices predicted for SAS2424 by TMHMM2.0 at aa 12-34, 78-100, 138-160, 180-202, 223-245, 283-305, 338-360, 364-386 and 393-415 282459011942 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 390.4, E-value 1.8e-114 282459011943 pyruvate oxidase; Provisional; Region: PRK08611 282459011944 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 282459011945 PYR/PP interface [polypeptide binding]; other site 282459011946 tetramer interface [polypeptide binding]; other site 282459011947 dimer interface [polypeptide binding]; other site 282459011948 TPP binding site [chemical binding]; other site 282459011949 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 282459011950 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 282459011951 TPP-binding site [chemical binding]; other site 282459011952 Pfam match to entry PF02775 TPP_enzymes_C, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 192.9, E-value 5.1e-55 282459011953 PS00187 Thiamine pyrophosphate enzymes signature. 282459011954 Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzyme, central domain, score 136.7, E-value 4.3e-38 282459011955 Pfam match to entry PF02776 TPP_enzymes_N, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 157.5, E-value 2.3e-44 282459011956 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 282459011957 Pfam match to entry PF04172 LrgB, LrgB-like family, score 386.8, E-value 2.2e-113 282459011958 6 probable transmembrane helices predicted for SAS2426 by TMHMM2.0 at aa 4-21, 30-52, 62-79, 90-112, 149-171 and 204-226 282459011959 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 282459011960 Pfam match to entry PF03788 LrgA, LrgA family, score 67.4, E-value 3.1e-17 282459011961 4 probable transmembrane helices predicted for SAS2427 by TMHMM2.0 at aa 7-25, 30-49, 62-82 and 92-114 282459011962 Transcriptional regulator [Transcription]; Region: LysR; COG0583 282459011963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 282459011964 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 282459011965 putative dimerization interface [polypeptide binding]; other site 282459011966 Pfam match to entry PF03466 LysR_substrate, LysR substrate binding domain, score 159.4, E-value 6.6e-45 282459011967 Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 91.5, E-value 1.8e-24 282459011968 PS00044 Bacterial regulatory proteins, lysR family signature. 282459011969 Predicted helix-turn-helix motif for SAS2428 with score 1179.000, SD 3.20 at aa 16-37, sequence GGMTNASKSLYIAQPTISKAIK 282459011970 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 282459011971 Surface antigen [General function prediction only]; Region: COG3942 282459011972 Signal peptide predicted for SAS2430 by SignalP 2.0 HMM (Signal peptide probabilty 0.930) with cleavage site probability 0.813 between residues 35 and 36; signal peptide 282459011973 CHAP domain; Region: CHAP; pfam05257 282459011974 Pfam match to entry PF05257 CHAP, CHAP domain, score 148.8, E-value 9.7e-42 282459011975 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 282459011976 homodimer interface [polypeptide binding]; other site 282459011977 catalytic residues [active] 282459011978 NAD binding site [chemical binding]; other site 282459011979 substrate binding pocket [chemical binding]; other site 282459011980 flexible flap; other site 282459011981 Pfam match to entry PF00368 HMG-CoA_red, Hydroxymethylglutaryl-coenzyme A reductase, score -27.0, E-value 1.3e-13 282459011982 PS01192 Hydroxymethylglutaryl-coenzyme A reductases signature 3. 282459011983 PS00066 Hydroxymethylglutaryl-coenzyme A reductases signature 1. 282459011984 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 282459011985 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 282459011986 dimer interface [polypeptide binding]; other site 282459011987 active site 282459011988 Pfam match to entry PF01154 HMG_CoA_synt, Hydroxymethylglutaryl-coenzyme A synthase, score -9.3, E-value 7.6e-14 282459011989 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 282459011990 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 282459011991 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 282459011992 DNA binding site [nucleotide binding] 282459011993 active site 282459011994 Pfam match to entry PF01035 Methyltransf_1, 6-O-methylguanine DNA methyltransferase, DNA binding domain, score 120.8, E-value 2.6e-33 282459011995 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 282459011996 Pfam match to entry PF02870 Methyltransf_1N, 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain, score 36.3, E-value 7.1e-08 282459011997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459011998 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 282459011999 Walker A motif; other site 282459012000 ATP binding site [chemical binding]; other site 282459012001 Walker B motif; other site 282459012002 arginine finger; other site 282459012003 UvrB/uvrC motif; Region: UVR; pfam02151 282459012004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 282459012005 Walker A motif; other site 282459012006 ATP binding site [chemical binding]; other site 282459012007 Walker B motif; other site 282459012008 arginine finger; other site 282459012009 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 282459012010 Pfam match to entry PF00004 AAA, ATPase family associated with various cellular activities (AAA), score 56.9, E-value 4.6e-14 282459012011 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012012 Pfam match to entry PF02151 UVR, UvrB/uvrC motif, score 24.9, E-value 0.00019 282459012013 Pfam match to entry PF00004 AAA, ATPase family associated with various cellular activities (AAA), score 4.2, E-value 0.00016 282459012014 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012015 Virus attachment protein p12 family; Region: P12; pfam12669 282459012016 1 probable transmembrane helix predicted for SAS2435 by TMHMM2.0 at aa 4-22 282459012017 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 282459012018 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 282459012019 G1 box; other site 282459012020 GTP/Mg2+ binding site [chemical binding]; other site 282459012021 Switch I region; other site 282459012022 G2 box; other site 282459012023 G3 box; other site 282459012024 Switch II region; other site 282459012025 G4 box; other site 282459012026 G5 box; other site 282459012027 Nucleoside recognition; Region: Gate; pfam07670 282459012028 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 282459012029 Nucleoside recognition; Region: Gate; pfam07670 282459012030 Pfam match to entry PF02421 FeoB, Ferrous iron transport protein B, score 877.8, E-value 3.6e-261 282459012031 10 probable transmembrane helices predicted for SAS2436 by TMHMM2.0 at aa 280-302, 342-364, 385-407, 422-444, 451-473, 514-536, 543-565, 580-599, 606-628 and 638-660 282459012032 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012033 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 282459012034 Signal peptide predicted for SAS2438 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.532 between residues 37 and 38; signal peptide 282459012035 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 282459012036 Protein export membrane protein; Region: SecD_SecF; cl14618 282459012037 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 282459012038 12 probable transmembrane helices predicted for SAS2438 by TMHMM2.0 at aa 17-39, 180-202, 204-226, 230-252, 264-298, 308-330, 354-376, 522-544, 549-568, 578-600, 633-652 and 662-684 282459012039 Pfam match to entry PF03176 MMPL, MMPL family, score 33.5, E-value 3.2e-07 282459012040 Pfam match to entry PF03176 MMPL, MMPL family, score 65.7, E-value 1e-16 282459012041 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 282459012042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 282459012043 Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 22.1, E-value 8.9e-06 282459012044 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 282459012045 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 282459012046 Glutamate binding site [chemical binding]; other site 282459012047 homodimer interface [polypeptide binding]; other site 282459012048 NAD binding site [chemical binding]; other site 282459012049 catalytic residues [active] 282459012050 Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family, score 588.5, E-value 4.2e-174 282459012051 PS00070 Aldehyde dehydrogenases cysteine active site. 282459012052 PS00687 Aldehyde dehydrogenases glutamic acid active site. 282459012053 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 282459012054 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 282459012055 active site 282459012056 substrate binding site [chemical binding]; other site 282459012057 trimer interface [polypeptide binding]; other site 282459012058 CoA binding site [chemical binding]; other site 282459012059 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 16.3, E-value 0.078 282459012060 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 4.1, E-value 31 282459012061 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 13.6, E-value 0.51 282459012062 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (three repeats), score 8.6, E-value 9 282459012063 Signal peptide predicted for SAS2442 by SignalP 2.0 HMM (Signal peptide probabilty 0.787) with cleavage site probability 0.499 between residues 23 and 24; signal peptide 282459012064 1 probable transmembrane helix predicted for SAS2442 by TMHMM2.0 at aa 4-21 282459012065 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 282459012066 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 282459012067 metal-binding site [ion binding] 282459012068 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 282459012069 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 282459012070 metal-binding site [ion binding] 282459012071 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 282459012072 Soluble P-type ATPase [General function prediction only]; Region: COG4087 282459012073 Pfam match to entry PF00403 HMA, Heavy-metal-associated domain, score 75.8, E-value 9.3e-20 282459012074 PS01047 Heavy-metal-associated domain. 282459012075 Pfam match to entry PF00403 HMA, Heavy-metal-associated domain, score 87.0, E-value 3.9e-23 282459012076 PS01047 Heavy-metal-associated domain. 282459012077 8 probable transmembrane helices predicted for SAS2443 by TMHMM2.0 at aa 158-180, 190-212, 219-241, 256-274, 407-429, 444-466, 748-767 and 771-790 282459012078 Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 ATPase, score 355.4, E-value 6.6e-104 282459012079 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase, score 141.5, E-value 1.6e-39 282459012080 PS00154 E1-E2 ATPases phosphorylation site. 282459012081 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 282459012082 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 282459012083 metal-binding site [ion binding] 282459012084 Pfam match to entry PF00403 HMA, Heavy-metal-associated domain, score 72.5, E-value 9.1e-19 282459012085 PS01047 Heavy-metal-associated domain. 282459012086 D-lactate dehydrogenase; Validated; Region: PRK08605 282459012087 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 282459012088 homodimer interface [polypeptide binding]; other site 282459012089 ligand binding site [chemical binding]; other site 282459012090 NAD binding site [chemical binding]; other site 282459012091 catalytic site [active] 282459012092 Pfam match to entry PF02826 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 217.2, E-value 2.5e-62 282459012093 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 282459012094 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 282459012095 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 282459012096 Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 103.1, E-value 5.9e-28 282459012097 transaminase; Reviewed; Region: PRK08068 282459012098 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 282459012099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459012100 homodimer interface [polypeptide binding]; other site 282459012101 catalytic residue [active] 282459012102 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class I and II, score 78.1, E-value 1.9e-20 282459012103 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 282459012104 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 282459012105 Signal peptide predicted for SAS2447 by SignalP 2.0 HMM (Signal peptide probabilty 0.835) with cleavage site probability 0.387 between residues 23 and 24; signal peptide 282459012106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 282459012107 Pfam match to entry PF01593 Amino_oxidase, Flavin containing amine oxidoreductase, score 58.4, E-value 1.6e-14 282459012108 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 282459012109 active site lid residues [active] 282459012110 substrate binding pocket [chemical binding]; other site 282459012111 catalytic residues [active] 282459012112 substrate-Mg2+ binding site; other site 282459012113 aspartate-rich region 1; other site 282459012114 aspartate-rich region 2; other site 282459012115 Pfam match to entry PF00494 SQS_PSY, Squalene/phytoene synthase, score 87.4, E-value 3e-23 282459012116 PS01044 Squalene and phytoene synthases signature 1. 282459012117 Signal peptide predicted for SAS2449 by SignalP 2.0 HMM (Signal peptide probabilty 0.911) with cleavage site probability 0.728 between residues 31 and 32; signal peptide 282459012118 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 282459012119 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 282459012120 active site 282459012121 4 probable transmembrane helices predicted for SAS2449 by TMHMM2.0 at aa 4-23, 164-186, 277-299 and 330-352 282459012122 Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferase, score 91.0, E-value 2.4e-24 282459012123 Signal peptide predicted for SAS2450 by SignalP 2.0 HMM (Signal peptide probabilty 0.803) with cleavage site probability 0.321 between residues 24 and 25; signal peptide 282459012124 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 282459012125 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 282459012126 Pfam match to entry PF01593 Amino_oxidase, Flavin containing amine oxidoreductase, score 24.5, E-value 5.9e-06 282459012127 1 probable transmembrane helix predicted for SAS2451 by TMHMM2.0 at aa 126-145 282459012128 Signal peptide predicted for SAS2452 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.987 between residues 26 and 27; signal peptide 282459012129 Surface antigen [General function prediction only]; Region: COG3942 282459012130 CHAP domain; Region: CHAP; pfam05257 282459012131 Pfam match to entry PF05257 CHAP, CHAP domain, score 174.5, E-value 1.8e-49 282459012132 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 282459012133 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 282459012134 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 282459012135 catalytic triad [active] 282459012136 catalytic triad [active] 282459012137 oxyanion hole [active] 282459012138 11 probable transmembrane helices predicted for SAS2453 by TMHMM2.0 at aa 17-39, 44-66, 87-105, 147-169, 176-198, 213-232, 239-261, 271-293, 313-330, 334-356 and 377-399 282459012139 Pfam match to entry PF01757 Acyl_transf_3, Acyltransferase family, score 213.3, E-value 3.9e-61 282459012140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459012141 Coenzyme A binding pocket [chemical binding]; other site 282459012142 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 57.2, E-value 3.8e-14 282459012143 Signal peptide predicted for SAS2455 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.910 between residues 29 and 30; signal peptide 282459012144 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 282459012145 N-acetyl-D-glucosamine binding site [chemical binding]; other site 282459012146 catalytic residue [active] 282459012147 Signal peptide predicted for SAS2456 by SignalP 2.0 HMM (Signal peptide probabilty 0.605) with cleavage site probability 0.331 between residues 35 and 36; signal peptide 282459012148 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 282459012149 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 282459012150 PS00636 Nt-dnaJ domain signature. 282459012151 10 probable transmembrane helices predicted for SAS2456 by TMHMM2.0 at aa 13-35, 50-72, 79-96, 106-128, 135-157, 172-194, 199-221, 225-247, 259-281 and 309-331 282459012152 PS00962 Ribosomal protein S2 signature 1. 282459012153 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 282459012154 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 282459012155 Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 22.8, E-value 5.8e-06 282459012156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 282459012157 Pfam match to entry PF05979 DUF896, Bacterial protein of unknown function (DUF896), score 157.8, E-value 2e-44 282459012158 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 282459012159 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 282459012160 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 22.8, E-value 0.00041 282459012161 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 282459012162 NmrA-like family; Region: NmrA; pfam05368 282459012163 NADP binding site [chemical binding]; other site 282459012164 active site 282459012165 regulatory binding site [polypeptide binding]; other site 282459012166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 282459012167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 282459012168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 282459012169 Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 49.0, E-value 1.1e-11 282459012170 PS01081 Bacterial regulatory proteins, tetR family signature. 282459012171 Predicted helix-turn-helix motif for SAS2464 with score 1867.000, SD 5.55 at aa 28-49, sequence ISMNRIAKELGIGMGTLYRHFK 282459012172 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 282459012173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 282459012174 NAD(P) binding site [chemical binding]; other site 282459012175 active site 282459012176 Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 137.0, E-value 3.5e-38 282459012177 PS00061 Short-chain dehydrogenases/reductases family signature. 282459012178 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 282459012179 Pfam match to entry PF04909 Amidohydro_2, Amidohydrolase, score 294.7, E-value 1.2e-85 282459012180 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 282459012181 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 282459012182 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 282459012183 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 282459012184 Pfam match to entry PF02492 cobW, Cobalamin synthesis protein/P47K, score 332.5, E-value 4.9e-97 282459012185 PS00217 Sugar transport proteins signature 2. 282459012186 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012187 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 282459012188 Nucleoside recognition; Region: Gate; pfam07670 282459012189 8 probable transmembrane helices predicted for SAS2469 by TMHMM2.0 at aa 86-108, 150-172, 231-253, 257-276, 312-334, 344-366, 390-412 and 427-446 282459012190 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 282459012191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 282459012192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 282459012193 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 282459012194 Phosphotransferase enzyme family; Region: APH; pfam01636 282459012195 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 282459012196 active site 282459012197 ATP binding site [chemical binding]; other site 282459012198 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 282459012199 Pfam match to entry PF03881 Fructosamin_kin, Fructosamine kinase, score 77.8, E-value 2.4e-20 282459012200 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 282459012201 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 282459012202 quinone interaction residues [chemical binding]; other site 282459012203 active site 282459012204 catalytic residues [active] 282459012205 FMN binding site [chemical binding]; other site 282459012206 substrate binding site [chemical binding]; other site 282459012207 Pfam match to entry PF01180 DHOdehase, Dihydroorotate dehydrogenase, score 302.0, E-value 7.7e-88 282459012208 PS00911 Dihydroorotate dehydrogenase signature 1. 282459012209 PS00912 Dihydroorotate dehydrogenase signature 2. 282459012210 1 probable transmembrane helix predicted for SAS2476 by TMHMM2.0 at aa 69-88 282459012211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 282459012212 Pfam match to entry PF02677 DUF208, Uncharacterized BCR, COG1636, score 135.4, E-value 1.1e-37 282459012213 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 282459012214 dimer interface [polypeptide binding]; other site 282459012215 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 282459012216 Pfam match to entry PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 20.4, E-value 1e-05 282459012217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 282459012218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 282459012219 Predicted helix-turn-helix motif for SAS2479 with score 1202.000, SD 3.28 at aa 30-51, sequence ITVQQIADLADVNRSTFYTHYY 282459012220 Predicted acyl esterases [General function prediction only]; Region: COG2936 282459012221 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 282459012222 Pfam match to entry PF02129 Peptidase_S15, X-Pro dipeptidyl-peptidase (S15 family), score 714.3, E-value 5.7e-212 282459012223 No significant database matches. CDS possibly contains either a nonsense or frameshift mutation at the N-terminus. In the absence of a mutation, the next translational start for the CDS generates a protein that lacks an N-terminal signal sequence; cell wall-anchored protein (pseudogene) 282459012224 1 probable transmembrane helix predicted for SAS2481 by TMHMM2.0 at aa 185-207 282459012225 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 15.2, E-value 0.00085 282459012226 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282459012227 Signal peptide predicted for SAS2481 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.986 between residues 25 and 26 282459012228 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 282459012229 tetramerization interface [polypeptide binding]; other site 282459012230 active site 282459012231 Pfam match to entry PF02261 Asp_decarbox, Aspartate decarboxylase, score 231.7, E-value 1.1e-66 282459012232 pantoate--beta-alanine ligase; Region: panC; TIGR00018 282459012233 Pantoate-beta-alanine ligase; Region: PanC; cd00560 282459012234 active site 282459012235 ATP-binding site [chemical binding]; other site 282459012236 pantoate-binding site; other site 282459012237 HXXH motif; other site 282459012238 Pfam match to entry PF02569 Pantoate_ligase, Pantoate-beta-alanine ligase, score 460.9, E-value 1.1e-135 282459012239 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 282459012240 oligomerization interface [polypeptide binding]; other site 282459012241 active site 282459012242 metal binding site [ion binding]; metal-binding site 282459012243 Pfam match to entry PF02548 Pantoate_transf, Ketopantoate hydroxymethyltransferase, score 414.2, E-value 1.3e-121 282459012244 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 282459012245 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 282459012246 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 282459012247 Pfam match to entry PF02558 ApbA, Ketopantoate reductase PanE/ApbA, score 119.2, E-value 8e-33 282459012248 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 282459012249 Pfam match to entry PF03306 AAL_decarboxy, Alpha-acetolactate decarboxylase, score 270.4, E-value 2.5e-78 282459012250 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 282459012251 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 282459012252 tetramer (dimer of dimers) interface [polypeptide binding]; other site 282459012253 NAD binding site [chemical binding]; other site 282459012254 dimer interface [polypeptide binding]; other site 282459012255 substrate binding site [chemical binding]; other site 282459012256 Pfam match to entry PF02866 ldh_C, lactate/malate dehydrogenase, alpha/beta C-terminal domain, score 238.9, E-value 7.7e-69 282459012257 PS00064 L-lactate dehydrogenase active site. 282459012258 Pfam match to entry PF00056 ldh, lactate/malate dehydrogenase, NAD binding domain, score 245.7, E-value 6.9e-71 282459012259 Signal peptide predicted for SAS2488 by SignalP 2.0 HMM (Signal peptide probabilty 0.933) with cleavage site probability 0.852 between residues 55 and 56; signal peptide 282459012260 amino acid transporter; Region: 2A0306; TIGR00909 282459012261 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score 99.9, E-value 5.2e-27 282459012262 12 probable transmembrane helices predicted for SAS2488 by TMHMM2.0 at aa 33-55, 59-81, 93-115, 155-174, 187-209, 229-246, 267-289, 309-331, 365-384, 388-405, 422-444 and 449-466 282459012263 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 282459012264 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 282459012265 inhibitor-cofactor binding pocket; inhibition site 282459012266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459012267 catalytic residue [active] 282459012268 Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III, score 411.1, E-value 1.1e-120 282459012269 Signal peptide predicted for SAS2490 by SignalP 2.0 HMM (Signal peptide probabilty 0.976) with cleavage site probability 0.658 between residues 32 and 33; signal peptide 282459012270 4 probable transmembrane helices predicted for SAS2490 by TMHMM2.0 at aa 7-29, 52-74, 81-103 and 113-135 282459012271 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 282459012272 catalytic residue [active] 282459012273 Pfam match to entry PF00274 glycolytic_enzy, Fructose-bisphosphate aldolase class-I, score 261.8, E-value 9.7e-76 282459012274 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 282459012275 Signal peptide predicted for SAS2492 by SignalP 2.0 HMM (Signal peptide probabilty 0.663) with cleavage site probability 0.637 between residues 27 and 28; signal peptide 282459012276 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 282459012277 Pfam match to entry PF06039 Mqo, Malate:quinone oxidoreductase (Mqo), score 1199.6, E-value 0 282459012278 2 probable transmembrane helices predicted for SAS2493 by TMHMM2.0 at aa 5-22 and 37-59 282459012279 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 282459012280 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 282459012281 acyl-activating enzyme (AAE) consensus motif; other site 282459012282 AMP binding site [chemical binding]; other site 282459012283 active site 282459012284 CoA binding site [chemical binding]; other site 282459012285 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 378.7, E-value 6.4e-111 282459012286 PS00455 AMP-binding domain signature. 282459012287 PS00211 ABC transporters family signature. 282459012288 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 282459012289 Pfam match to entry PF03992 ABM, Antibiotic biosynthesis monooxygenase, score 59.2, E-value 9.6e-15 282459012290 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 282459012291 choline dehydrogenase; Validated; Region: PRK02106 282459012292 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 282459012293 PS00044 Bacterial regulatory proteins, lysR family signature. 282459012294 Pfam match to entry PF05199 GMC_oxred_C, GMC oxidoreductase, score 259.1, E-value 6.3e-75 282459012295 Pfam match to entry PF00732 GMC_oxred_N, GMC oxidoreductase, score 392.7, E-value 3.7e-115 282459012296 PS00624 GMC oxidoreductases signature 2. 282459012297 PS00623 GMC oxidoreductases signature 1. 282459012298 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 282459012299 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 282459012300 tetramerization interface [polypeptide binding]; other site 282459012301 NAD(P) binding site [chemical binding]; other site 282459012302 catalytic residues [active] 282459012303 Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family, score 702.6, E-value 2e-208 282459012304 PS00070 Aldehyde dehydrogenases cysteine active site. 282459012305 PS00687 Aldehyde dehydrogenases glutamic acid active site. 282459012306 Predicted transcriptional regulators [Transcription]; Region: COG1510 282459012307 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 282459012308 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily, score 25.6, E-value 1.2e-06 282459012309 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 282459012310 Signal peptide predicted for SAS2501 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.546 between residues 32 and 33; signal peptide 282459012311 Pfam match to entry PF02028 BCCT, BCCT family transporter, score 471.5, E-value 7.1e-139 282459012312 12 probable transmembrane helices predicted for SAS2501 by TMHMM2.0 at aa 12-29, 44-66, 87-109, 140-162, 192-214, 229-248, 260-282, 321-343, 356-378, 413-435, 448-470 and 483-505 282459012313 PS01303 BCCT family of transporters signature. 282459012314 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282459012315 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 282459012316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 282459012317 FeS/SAM binding site; other site 282459012318 Pfam match to entry PF04055 Radical_SAM, Radical SAM superfamily, score 29.2, E-value 7.3e-08 282459012319 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 282459012320 Class III ribonucleotide reductase; Region: RNR_III; cd01675 282459012321 effector binding site; other site 282459012322 active site 282459012323 Zn binding site [ion binding]; other site 282459012324 glycine loop; other site 282459012325 Pfam match to entry PF01228 Gly_radical, Glycine radical, score 109.7, E-value 5.9e-30 282459012326 PS00850 Glycine radical signature. 282459012327 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 282459012328 Citrate transporter; Region: CitMHS; pfam03600 282459012329 Pfam match to entry PF03600 CitMHS, Citrate transporter, score 959.1, E-value 1.2e-285 282459012330 12 probable transmembrane helices predicted for SAS2504 by TMHMM2.0 at aa 5-24, 31-53, 63-80, 93-115, 120-139, 144-166, 181-203, 253-275, 310-327, 340-362, 398-420 and 432-454 282459012331 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 282459012332 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 282459012333 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 282459012334 Flavodoxin; Region: Flavodoxin_1; pfam00258 282459012335 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 282459012336 FAD binding pocket [chemical binding]; other site 282459012337 FAD binding motif [chemical binding]; other site 282459012338 catalytic residues [active] 282459012339 NAD binding pocket [chemical binding]; other site 282459012340 phosphate binding motif [ion binding]; other site 282459012341 beta-alpha-beta structure motif; other site 282459012342 Pfam match to entry PF00175 NAD_binding_1, Oxidoreductase NAD-binding domain, score 128.1, E-value 1.7e-35 282459012343 Pfam match to entry PF00667 FAD_binding_1, FAD binding domain, score 86.1, E-value 7.7e-23 282459012344 Pfam match to entry PF00258 flavodoxin, Flavodoxin, score 160.0, E-value 4.2e-45 282459012345 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 282459012346 catalytic residues [active] 282459012347 dimer interface [polypeptide binding]; other site 282459012348 Pfam match to entry PF00255 GSHPx, Glutathione peroxidase, score 119.4, E-value 6.9e-33 282459012349 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 282459012350 FtsX-like permease family; Region: FtsX; pfam02687 282459012351 10 probable transmembrane helices predicted for SAS2508 by TMHMM2.0 at aa 21-43, 53-75, 113-135, 155-177, 198-217, 232-254, 284-306, 538-560, 596-618 and 628-650 282459012352 Pfam match to entry PF02687 FtsX, Predicted permease, score 12.5, E-value 5.6e-05 282459012353 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 282459012354 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282459012355 Walker A/P-loop; other site 282459012356 ATP binding site [chemical binding]; other site 282459012357 Q-loop/lid; other site 282459012358 ABC transporter signature motif; other site 282459012359 Walker B; other site 282459012360 D-loop; other site 282459012361 H-loop/switch region; other site 282459012362 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 210.5, E-value 2.7e-60 282459012363 PS00211 ABC transporters family signature. 282459012364 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012365 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 282459012366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 282459012367 ATP binding site [chemical binding]; other site 282459012368 Mg2+ binding site [ion binding]; other site 282459012369 G-X-G motif; other site 282459012370 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 96.6, E-value 5.3e-26 282459012371 2 probable transmembrane helices predicted for SAS2510 by TMHMM2.0 at aa 13-30 and 35-57 282459012372 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 282459012373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 282459012374 active site 282459012375 phosphorylation site [posttranslational modification] 282459012376 intermolecular recognition site; other site 282459012377 dimerization interface [polypeptide binding]; other site 282459012378 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 282459012379 DNA binding site [nucleotide binding] 282459012380 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 71.8, E-value 1.5e-18 282459012381 Pfam match to entry PF00072 response_reg, Response regulator receiver domain, score 101.3, E-value 2e-27 282459012382 1 probable transmembrane helix predicted for SAS2512 by TMHMM2.0 at aa 4-21 282459012383 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 282459012384 Signal peptide predicted for SAS2513 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.680 between residues 30 and 31; signal peptide 282459012385 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 282459012386 dimer interface [polypeptide binding]; other site 282459012387 active site 282459012388 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 282459012389 Pfam match to entry PF00245 alk_phosphatase, Alkaline phosphatase, score 329.9, E-value 3.1e-96 282459012390 PS00123 Alkaline phosphatase active site. 282459012391 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012392 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 282459012393 1 probable transmembrane helix predicted for SAS2513a by TMHMM2.0 at aa 4-18 282459012394 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 282459012395 MarR family; Region: MarR_2; pfam12802 282459012396 Predicted esterase [General function prediction only]; Region: COG0627 282459012397 S-formylglutathione hydrolase; Region: PLN02442 282459012398 Pfam match to entry PF00756 Esterase, esterase, score 2.2, E-value 2.4e-05 282459012399 Signal peptide predicted for SAS2516 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.679 between residues 44 and 45; signal peptide 282459012400 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 282459012401 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 282459012402 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 48.7, E-value 1.3e-11 282459012403 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282459012404 Pfam match to entry PF02412 tsp_3, Thrombospondin type 3 repeat, score 1.4, E-value 81 282459012405 1 probable transmembrane helix predicted for SAS2516 by TMHMM2.0 at aa 20-37 282459012406 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 49.3, E-value 8.7e-12 282459012407 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 282459012408 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 282459012409 ligand binding site [chemical binding]; other site 282459012410 flexible hinge region; other site 282459012411 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 282459012412 Predicted helix-turn-helix motif for SAS2517 with score 1236.000, SD 3.40 at aa 186-207, sequence LTIQLMSDMAGISRETAGHIIH 282459012413 carbamate kinase; Reviewed; Region: PRK12686 282459012414 Signal peptide predicted for SAS2518 by SignalP 2.0 HMM (Signal peptide probabilty 0.689) with cleavage site probability 0.242 between residues 30 and 31; signal peptide 282459012415 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 282459012416 putative substrate binding site [chemical binding]; other site 282459012417 nucleotide binding site [chemical binding]; other site 282459012418 nucleotide binding site [chemical binding]; other site 282459012419 homodimer interface [polypeptide binding]; other site 282459012420 Pfam match to entry PF00696 aakinase, Amino acid kinase family, score 278.0, E-value 1.3e-80 282459012421 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 282459012422 14 probable transmembrane helices predicted for SAS2519 by TMHMM2.0 at aa 15-33, 40-62, 77-99, 101-123, 128-147, 159-181, 211-230, 243-265, 280-302, 336-358, 362-384, 401-418, 423-440 and 453-475 282459012423 Pfam match to entry PF00324 aa_permeases, Amino acid permease, score -27.0, E-value 7.4e-07 282459012424 ornithine carbamoyltransferase; Validated; Region: PRK02102 282459012425 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 282459012426 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 282459012427 Pfam match to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain, score 265.7, E-value 6.3e-77 282459012428 Pfam match to entry PF02729 OTCace_N, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain, score 238.1, E-value 1.3e-68 282459012429 PS00097 Aspartate and ornithine carbamoyltransferases signature. 282459012430 arginine deiminase; Provisional; Region: PRK01388 282459012431 Pfam match to entry PF02274 Amidinotransf, Amidinotransferase, score 707.3, E-value 7.3e-210 282459012432 Arginine repressor [Transcription]; Region: ArgR; COG1438 282459012433 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 282459012434 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 282459012435 Pfam match to entry PF02863 Arg_repressor_C, Arginine repressor, C-terminal domain, score 38.0, E-value 2.2e-08 282459012436 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 282459012437 Signal peptide predicted for SAS2523 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.899 between residues 27 and 28; signal peptide 282459012438 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 282459012439 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 282459012440 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 282459012441 active site 282459012442 Zn binding site [ion binding]; other site 282459012443 Pfam match to entry PF02868 Peptidase_M4_C, Thermolysin metallopeptidase, alpha-helical domain, score 301.8, E-value 8.8e-88 282459012444 Pfam match to entry PF01447 Peptidase_M4, Thermolysin metallopeptidase, catalytic domain, score 240.8, E-value 2.1e-69 282459012445 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 282459012446 Pfam match to entry PF03413 Pep_M4_propep, Thermolysin metallopeptidase, propeptide, score 29.6, E-value 2.8e-07 282459012447 Signal peptide predicted for SAS2524 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.914 between residues 36 and 37; signal peptide 282459012448 2 probable transmembrane helices predicted for SAS2524 by TMHMM2.0 at aa 7-24 and 34-56 282459012449 Signal peptide predicted for SAS2525 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.382 between residues 28 and 29; signal peptide 282459012450 1 probable transmembrane helix predicted for SAS2525 by TMHMM2.0 at aa 10-32 282459012451 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 282459012452 HTH domain; Region: HTH_11; pfam08279 282459012453 PRD domain; Region: PRD; pfam00874 282459012454 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 282459012455 active site 282459012456 P-loop; other site 282459012457 phosphorylation site [posttranslational modification] 282459012458 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282459012459 active site 282459012460 phosphorylation site [posttranslational modification] 282459012461 Predicted helix-turn-helix motif for SAS2526 with score 1430.000, SD 4.06 at aa 20-41, sequence ISSNEIAEHVNVSNRTVRNDIH 282459012462 Pfam match to entry PF00874 PRD, PRD domain, score 106.0, E-value 7.8e-29 282459012463 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score -2.8, E-value 1.4e-05 282459012464 PS00372 PTS EIIA domains phosphorylation site signature 2. 282459012465 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 282459012466 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 282459012467 active site 282459012468 P-loop; other site 282459012469 phosphorylation site [posttranslational modification] 282459012470 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 282459012471 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 282459012472 active site 282459012473 phosphorylation site [posttranslational modification] 282459012474 Pfam match to entry PF02379 PTS_IIB_fruc, PTS system, Fructose specific IIB subunit, score 189.8, E-value 4.4e-54 282459012475 Pfam match to entry PF02378 PTS_EIIC, Phosphotransferase system, EIIC, score 186.8, E-value 3.7e-53 282459012476 8 probable transmembrane helices predicted for SAS2527 by TMHMM2.0 at aa 133-155, 175-197, 218-240, 255-277, 298-317, 337-359, 398-417 and 437-459 282459012477 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 33.2, E-value 2.3e-08 282459012478 PS00372 PTS EIIA domains phosphorylation site signature 2. 282459012479 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 282459012480 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 282459012481 Pfam match to entry PF01238 PMI_typeI, Phosphomannose isomerase type I, score 238.3, E-value 1.1e-68 282459012482 Signal peptide predicted for SAS2529 by SignalP 2.0 HMM (Signal peptide probabilty 0.654) with cleavage site probability 0.434 between residues 36 and 37; signal peptide 282459012483 Predicted membrane protein [Function unknown]; Region: COG1511 282459012484 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 282459012485 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 282459012486 6 probable transmembrane helices predicted for SAS2529 by TMHMM2.0 at aa 21-43, 793-815, 836-858, 868-890, 897-919 and 949-971 282459012487 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012488 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 282459012489 Signal peptide predicted for SAS2530 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.989 between residues 27 and 28; signal peptide 282459012490 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 282459012491 CHAP domain; Region: CHAP; pfam05257 282459012492 Pfam match to entry PF01832 Amidase_4, Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase, score 140.9, E-value 2.4e-39 282459012493 Pfam match to entry PF05257 CHAP, CHAP domain, score 174.8, E-value 1.5e-49 282459012494 Isochorismatase family; Region: Isochorismatase; pfam00857 282459012495 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 282459012496 catalytic triad [active] 282459012497 conserved cis-peptide bond; other site 282459012498 Pfam match to entry PF00857 Isochorismatase, Isochorismatase family, score 63.9, E-value 3.7e-16 282459012499 Signal peptide predicted for SAS2532 by SignalP 2.0 HMM (Signal peptide probabilty 0.978) with cleavage site probability 0.924 between residues 37 and 38; signal peptide 282459012500 1 probable transmembrane helix predicted for SAS2532 by TMHMM2.0 at aa 607-626 282459012501 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 282459012502 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 282459012503 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 282459012504 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 282459012505 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 77.3, E-value 3.3e-20 282459012506 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 282459012507 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 282459012508 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 282459012509 Pfam match to entry PF01043 SecA_protein, SecA protein, amino terminal region, score 512.8, E-value 2.7e-151 282459012510 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 282459012511 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 282459012512 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 282459012513 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 282459012514 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 282459012515 SecY translocase; Region: SecY; pfam00344 282459012516 10 probable transmembrane helices predicted for SAS2539 by TMHMM2.0 at aa 21-43, 63-85, 105-123, 133-151, 158-177, 187-209, 230-252, 280-302, 337-359 and 369-391 282459012517 Pfam match to entry PF00344 secY, eubacterial secY protein, score -33.1, E-value 1.3e-12 282459012518 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 282459012519 legume lectins; Region: lectin_L-type; cd01951 282459012520 homotetramer interaction site [polypeptide binding]; other site 282459012521 carbohydrate binding site [chemical binding]; other site 282459012522 metal binding site [ion binding]; metal-binding site 282459012523 Putative Ig domain; Region: He_PIG; pfam05345 282459012524 Pfam match to entry PF00746 Gram_pos_anchor, Gram positive anchor, score 37.0, E-value 4.6e-08 282459012525 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 282459012526 Pfam match to entry PF05345 He_PIG, Ig domain, score 81.3, E-value 2e-21 282459012527 Pfam match to entry PF05345 He_PIG, Ig domain, score 76.5, E-value 5.9e-20 282459012528 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 282459012529 Signal peptide predicted for SAS2542 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.858 between residues 28 and 29; signal peptide 282459012530 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459012531 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 282459012532 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 282459012533 methionine sulfoxide reductase A; Provisional; Region: PRK05528 282459012534 Pfam match to entry PF01625 PMSR, Peptide methionine sulfoxide reductase, score 106.6, E-value 5.2e-29 282459012535 1 probable transmembrane helix predicted for SAS2546 by TMHMM2.0 at aa 4-26 282459012536 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 282459012537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 282459012538 Coenzyme A binding pocket [chemical binding]; other site 282459012539 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 69.9, E-value 5.6e-18 282459012540 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 282459012541 Pfam match to entry PF02811 PHP_C, PHP domain C-terminal region, score 32.0, E-value 1.5e-06 282459012542 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 282459012543 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 282459012544 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 282459012545 Signal peptide predicted for SAS2550 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.521 between residues 39 and 40; signal peptide 282459012546 Chain length determinant protein; Region: Wzz; cl15801 282459012547 2 probable transmembrane helices predicted for SAS2550 by TMHMM2.0 at aa 20-39 and 169-191 282459012548 Pfam match to entry PF02706 wzz, Chain length determinant protein, score 158.5, E-value 1.2e-44 282459012549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 282459012550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 282459012551 Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 61.1, E-value 2.5e-15 282459012552 Predicted helix-turn-helix motif for SAS2551 with score 1314.000, SD 3.66 at aa 21-42, sequence TTLDDIAKSVNIKKASLYYHFD 282459012553 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 282459012554 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 282459012555 DXD motif; other site 282459012556 4 probable transmembrane helices predicted for SAS2552 by TMHMM2.0 at aa 6-28, 290-312, 332-354 and 366-388 282459012557 Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferase, score 125.7, E-value 8.8e-35 282459012558 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 282459012559 2 probable transmembrane helices predicted for SAS2553 by TMHMM2.0 at aa 24-46 and 71-93 282459012560 Signal peptide predicted for SAS2554 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.970 between residues 30 and 31; signal peptide 282459012561 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 282459012562 1 probable transmembrane helix predicted for SAS2554 by TMHMM2.0 at aa 7-29 282459012563 Pfam match to entry PF01522 Polysacc_deacet, Polysaccharide deacetylase, score 150.1, E-value 4.2e-42 282459012564 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 282459012565 Acyltransferase family; Region: Acyl_transf_3; pfam01757 282459012566 Pfam match to entry PF01757 Acyl_transf_3, Acyltransferase family, score -40.6, E-value 0.0016 282459012567 10 probable transmembrane helices predicted for SAS2555 by TMHMM2.0 at aa 7-29, 44-66, 79-101, 116-138, 145-167, 187-204, 211-233, 243-262, 269-291 and 306-328 282459012568 PS00284 Serpins signature. 282459012569 Signal peptide predicted for SAS2556 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.969 between residues 35 and 36; signal peptide 282459012570 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 282459012571 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 282459012572 PS00120 Lipases, serine active site. 282459012573 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012574 1 probable transmembrane helix predicted for SAS2556 by TMHMM2.0 at aa 13-35 282459012575 Pfam match to entry PF04650 YSIRK_signal, YSIRK type signal peptide, score 52.5, E-value 9.6e-13 282459012576 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 282459012577 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 282459012578 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 282459012579 metal binding site [ion binding]; metal-binding site 282459012580 Pfam match to entry PF01503 PRA-PH, Phosphoribosyl-ATP pyrophosphohydrolase, score 111.6, E-value 1.6e-30 282459012581 Pfam match to entry PF01502 PRA-CH, Phosphoribosyl-AMP cyclohydrolase, score 154.2, E-value 2.4e-43 282459012582 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 282459012583 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 282459012584 substrate binding site [chemical binding]; other site 282459012585 glutamase interaction surface [polypeptide binding]; other site 282459012586 Pfam match to entry PF00977 His_biosynth, Histidine biosynthesis protein, score 373.4, E-value 2.5e-109 282459012587 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 282459012588 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 282459012589 catalytic residues [active] 282459012590 Pfam match to entry PF00977 His_biosynth, Histidine biosynthesis protein, score 66.9, E-value 4.5e-17 282459012591 PS00152 ATP synthase alpha and beta subunits signature. 282459012592 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 282459012593 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 282459012594 putative active site [active] 282459012595 oxyanion strand; other site 282459012596 catalytic triad [active] 282459012597 Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I, score 95.1, E-value 1.5e-25 282459012598 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 282459012599 putative active site pocket [active] 282459012600 4-fold oligomerization interface [polypeptide binding]; other site 282459012601 metal binding residues [ion binding]; metal-binding site 282459012602 3-fold/trimer interface [polypeptide binding]; other site 282459012603 Pfam match to entry PF00475 IGPD, Imidazoleglycerol-phosphate dehydratase, score 245.4, E-value 8.5e-71 282459012604 PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. 282459012605 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 282459012606 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 282459012607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 282459012608 homodimer interface [polypeptide binding]; other site 282459012609 catalytic residue [active] 282459012610 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class I and II, score 40.9, E-value 3e-09 282459012611 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 282459012612 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 282459012613 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 282459012614 NAD binding site [chemical binding]; other site 282459012615 dimerization interface [polypeptide binding]; other site 282459012616 product binding site; other site 282459012617 substrate binding site [chemical binding]; other site 282459012618 zinc binding site [ion binding]; other site 282459012619 catalytic residues [active] 282459012620 Pfam match to entry PF00815 Histidinol_dh, Histidinol dehydrogenase, score 456.0, E-value 3.4e-134 282459012621 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 282459012622 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 282459012623 Pfam match to entry PF01634 HisG, ATP phosphoribosyltransferase, score 172.9, E-value 5.6e-49 282459012624 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 282459012625 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 282459012626 Signal peptide predicted for SAS2566 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.968 between residues 28 and 29; signal peptide 282459012627 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 282459012628 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 282459012629 putative active site [active] 282459012630 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 282459012631 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 282459012632 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 282459012633 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 282459012634 5 probable transmembrane helices predicted for SAS2568 by TMHMM2.0 at aa 21-38, 43-60, 67-86, 115-137 and 248-267 282459012635 Pfam match to entry PF02361 CbiQ, Cobalt transport protein, score 91.4, E-value 1.9e-24 282459012636 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 282459012637 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 282459012638 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 282459012639 Walker A/P-loop; other site 282459012640 ATP binding site [chemical binding]; other site 282459012641 Q-loop/lid; other site 282459012642 ABC transporter signature motif; other site 282459012643 Walker B; other site 282459012644 D-loop; other site 282459012645 H-loop/switch region; other site 282459012646 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 282459012647 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 282459012648 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 282459012649 Walker A/P-loop; other site 282459012650 ATP binding site [chemical binding]; other site 282459012651 Q-loop/lid; other site 282459012652 ABC transporter signature motif; other site 282459012653 Walker B; other site 282459012654 D-loop; other site 282459012655 H-loop/switch region; other site 282459012656 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 164.6, E-value 1.7e-46 282459012657 PS00211 ABC transporters family signature. 282459012658 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012659 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 133.6, E-value 3.7e-37 282459012660 PS00211 ABC transporters family signature. 282459012661 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012662 Signal peptide predicted for SAS2570 by SignalP 2.0 HMM (Signal peptide probabilty 0.876) with cleavage site probability 0.284 between residues 44 and 45; signal peptide 282459012663 hypothetical protein; Provisional; Region: PRK13661 282459012664 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 282459012665 5 probable transmembrane helices predicted for SAS2570 by TMHMM2.0 at aa 10-29, 42-64, 79-101, 114-136 and 146-168 282459012666 Uncharacterized conserved protein [Function unknown]; Region: COG1912 282459012667 Pfam match to entry PF01887 DUF62, Protein of unknown function DUF62, score 254.7, E-value 1.4e-73 282459012668 Uncharacterized conserved protein [Function unknown]; Region: COG2353 282459012669 Pfam match to entry PF04264 YceI, YceI like family, score 254.4, E-value 1.6e-73 282459012670 2 probable transmembrane helices predicted for SAS2573 by TMHMM2.0 at aa 2-21 and 31-53 282459012671 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 282459012672 Strictosidine synthase; Region: Str_synth; pfam03088 282459012673 Pfam match to entry PF01731 Arylesterase, Arylesterase, score 20.3, E-value 0.00013 282459012674 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 282459012675 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 282459012676 active site residue [active] 282459012677 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 282459012678 Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain, score 71.4, E-value 2e-18 282459012679 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 282459012680 putative substrate binding pocket [chemical binding]; other site 282459012681 AC domain interface; other site 282459012682 catalytic triad [active] 282459012683 AB domain interface; other site 282459012684 interchain disulfide; other site 282459012685 Pfam match to entry PF01470 Peptidase_C15, Pyroglutamyl peptidase, score 479.7, E-value 2.5e-141 282459012686 PS01333 Pyrrolidone-carboxylate peptidase glutamic acid active site. 282459012687 PS01334 Pyrrolidone-carboxylate peptidase cysteine active site. 282459012688 DinB superfamily; Region: DinB_2; pfam12867 282459012689 Signal peptide predicted for SAS2578 by SignalP 2.0 HMM (Signal peptide probabilty 0.958) with cleavage site probability 0.906 between residues 29 and 30; signal peptide 282459012690 Collagen binding domain; Region: Collagen_bind; pfam05737 282459012691 Cna protein B-type domain; Region: Cna_B; pfam05738 282459012692 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 282459012693 domain interaction interfaces [polypeptide binding]; other site 282459012694 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 282459012695 domain interaction interfaces [polypeptide binding]; other site 282459012696 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 282459012697 domain interaction interfaces [polypeptide binding]; other site 282459012698 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 282459012699 domain interaction interfaces [polypeptide binding]; other site 282459012700 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 282459012701 domain interaction interfaces [polypeptide binding]; other site 282459012702 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 282459012703 domain interaction interfaces [polypeptide binding]; other site 282459012704 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 282459012705 domain interaction interfaces [polypeptide binding]; other site 282459012706 1 probable transmembrane helix predicted for SAS2578 by TMHMM2.0 at aa 1158-1177 282459012707 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 33.3, E-value 5.8e-07 282459012708 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 38.0, E-value 2.2e-08 282459012709 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 35.3, E-value 1.5e-07 282459012710 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 40.0, E-value 5.8e-09 282459012711 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 33.3, E-value 5.8e-07 282459012712 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 40.0, E-value 5.8e-09 282459012713 Pfam match to entry PF05738 Cna_B, Cna protein B-type domain, score 62.3, E-value 1.1e-15 282459012714 Pfam match to entry PF05737 Collagen_bind, Collagen binding domain, score 199.8, E-value 4.3e-57 282459012715 Signal peptide predicted for SAS2579 by SignalP 2.0 HMM (Signal peptide probabilty 0.756) with cleavage site probability 0.387 between residues 30 and 31; signal peptide 282459012716 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 282459012717 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 282459012718 transmembrane helices; other site 282459012719 Pfam match to entry PF00939 Na_sulph_symp, Sodium:sulfate symporter transmembrane region, score 685.0, E-value 3.9e-203 282459012720 12 probable transmembrane helices predicted for SAS2579 by TMHMM2.0 at aa 7-24, 34-51, 56-73, 78-100, 174-196, 216-238, 272-290, 294-313, 326-348, 358-380, 392-414 and 443-465 282459012721 similar to hypothetical protein; Doubtful CDS 282459012722 Predicted permeases [General function prediction only]; Region: RarD; COG2962 282459012723 EamA-like transporter family; Region: EamA; pfam00892 282459012724 10 probable transmembrane helices predicted for SAS2580 by TMHMM2.0 at aa 7-29, 34-56, 77-99, 103-125, 132-149, 154-172, 179-201, 216-235, 240-262 and 272-291 282459012725 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6, score 34.3, E-value 2.9e-07 282459012726 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6, score 51.8, E-value 1.6e-12 282459012727 hypothetical protein; Provisional; Region: PRK07758 282459012728 Predicted helix-turn-helix motif for SAS2581 with score 1265.000, SD 3.50 at aa 28-49, sequence YTKSSLMEMHGVGPKAISILEQ 282459012729 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 282459012730 7 probable transmembrane helices predicted for SAS2582 by TMHMM2.0 at aa 10-32, 79-101, 121-143, 185-207, 217-239, 260-282 and 307-329 282459012731 Pfam match to entry PF03824 NicO, High-affinity nickel-transport protein, score 544.2, E-value 9.1e-161 282459012732 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 282459012733 Pfam match to entry PF00797 Acetyltransf2, N-acetyltransferase, score 16.2, E-value 7.7e-10 282459012734 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 282459012735 Signal peptide predicted for SAS2584 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.589 between residues 35 and 36; signal peptide 282459012736 6 probable transmembrane helices predicted for SAS2584 by TMHMM2.0 at aa 7-29, 33-55, 68-90, 94-116, 123-140 and 144-166 282459012737 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 282459012738 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282459012739 Walker A/P-loop; other site 282459012740 ATP binding site [chemical binding]; other site 282459012741 Q-loop/lid; other site 282459012742 ABC transporter signature motif; other site 282459012743 Walker B; other site 282459012744 D-loop; other site 282459012745 H-loop/switch region; other site 282459012746 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 193.3, E-value 4e-55 282459012747 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012748 Signal peptide predicted for SAS2586 by SignalP 2.0 HMM (Signal peptide probabilty 0.625) with cleavage site probability 0.438 between residues 46 and 47; signal peptide 282459012749 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 282459012750 FtsX-like permease family; Region: FtsX; pfam02687 282459012751 10 probable transmembrane helices predicted for SAS2586 by TMHMM2.0 at aa 21-38, 58-80, 109-131, 153-175, 197-219, 229-251, 290-312, 506-528, 562-584 and 594-616 282459012752 Pfam match to entry PF02687 FtsX, Predicted permease, score 33.6, E-value 4.7e-07 282459012753 1 probable transmembrane helix predicted for SAS2586a by TMHMM2.0 at aa 21-43 282459012754 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 282459012755 DNA-binding site [nucleotide binding]; DNA binding site 282459012756 RNA-binding motif; other site 282459012757 Pfam match to entry PF00313 CSD, 'Cold-shock' DNA-binding domain, score 144.0, E-value 2.9e-40 282459012758 PS00352 'Cold-shock' DNA-binding domain signature. 282459012759 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 282459012760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282459012761 non-specific DNA binding site [nucleotide binding]; other site 282459012762 salt bridge; other site 282459012763 sequence-specific DNA binding site [nucleotide binding]; other site 282459012764 3 probable transmembrane helices predicted for SAS2588 by TMHMM2.0 at aa 80-102, 106-123 and 163-185 282459012765 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 68.1, E-value 2e-17 282459012766 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 282459012767 4 probable transmembrane helices predicted for SAS2589 by TMHMM2.0 at aa 5-27, 31-53, 60-82 and 92-114 282459012768 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 282459012769 4 probable transmembrane helices predicted for SAS2590 by TMHMM2.0 at aa 4-25, 32-51, 66-88 and 95-114 282459012770 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 282459012771 ParB-like nuclease domain; Region: ParBc; pfam02195 282459012772 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012773 Predicted helix-turn-helix motif for SAS2591 with score 1898.000, SD 5.65 at aa 143-164, sequence TTQSELAKSLGKSQSFIANKLR 282459012774 Pfam match to entry PF02195 ParBc, ParB-like nuclease domain, score 122.6, E-value 7.6e-34 282459012775 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 282459012776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 282459012777 S-adenosylmethionine binding site [chemical binding]; other site 282459012778 Pfam match to entry PF02527 GidB, Glucose inhibited division protein, score 267.4, E-value 2e-77 282459012779 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 282459012780 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 282459012781 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 282459012782 Predicted helix-turn-helix motif for SAS2593 with score 1139.000, SD 3.07 at aa 592-613, sequence LNIAQASRISGVNPADISILLI 282459012783 Pfam match to entry PF01134 GIDA, Glucose inhibited division protein A, score 828.2, E-value 2.9e-246 282459012784 PS01281 Glucose inhibited division protein A family signature 2. 282459012785 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 282459012786 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 282459012787 trmE is a tRNA modification GTPase; Region: trmE; cd04164 282459012788 G1 box; other site 282459012789 GTP/Mg2+ binding site [chemical binding]; other site 282459012790 Switch I region; other site 282459012791 G2 box; other site 282459012792 Switch II region; other site 282459012793 G3 box; other site 282459012794 G4 box; other site 282459012795 G5 box; other site 282459012796 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 282459012797 Pfam match to entry PF01926 MMR_HSR1, GTPase of unknown function, score 7.4, E-value 1.7e-07 282459012798 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012799 ribonuclease P; Reviewed; Region: rnpA; PRK00499 282459012800 Pfam match to entry PF00825 Ribonuclease_P, Ribonuclease P, score 105.6, E-value 1e-28 282459012801 PS00648 Bacterial ribonuclease P protein component signature. 282459012802 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 282459012803 Pfam match to entry PF00468 Ribosomal_L34, Ribosomal protein L34, score 77.6, E-value 2.7e-20 282459012804 PS00784 Ribosomal protein L34 signature. 282459012805 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 282459012806 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 282459012807 Walker A/P-loop; other site 282459012808 ATP binding site [chemical binding]; other site 282459012809 Q-loop/lid; other site 282459012810 ABC transporter signature motif; other site 282459012811 Walker B; other site 282459012812 D-loop; other site 282459012813 H-loop/switch region; other site 282459012814 Pfam match to entry PF00005 ABC_tran, ABC transporter, score 191.1, E-value 1.1e-54 282459012815 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012816 PS00211 ABC transporters family signature. 282459012817 Similar to Staphylococcus aureus plasmid pT181 recombination enzyme SW:PRE3_STAAU (P03864) (413 aa) fasta scores: E(): 1.3e-64, 55.92% id in 422 aa, and to Staphylococcus cohnii recombination/mobilization protein Pre TR:O87277 (EMBL:AF015628) (420 aa) fasta scores: E(): 9.9e-28, 31.64% id in 433 aa. Contains nonsense mutations (amber) after codons 101 and 209;putative plasmid recombination enzyme (pseudogene) 282459012818 Pfam match to entry PF01076 Mob_Pre, Plasmid recombination enzyme, score 326.3, E-value 2.1e-95 282459012819 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 282459012820 Initiator Replication protein; Region: Rep_3; pfam01051 282459012821 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 282459012822 non-specific DNA binding site [nucleotide binding]; other site 282459012823 salt bridge; other site 282459012824 sequence-specific DNA binding site [nucleotide binding]; other site 282459012825 Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 70.5, E-value 2.1e-18 282459012826 1 probable transmembrane helix predicted for pSAS.06 by TMHMM2.0 at aa 53-72 282459012827 Similar to the N-terminal regions of Staphylococcus aureus plasmid pSV41 putative replication initiation protein Rep TR:O87367 (EMBL:AF051917) (319 aa) fasta scores: E(): 5.6e-27, 56.29% id in 151 aa, and Enterococcus faecalis plasmid pCF10 regulatory protein PrgW TR:Q51642 (EMBL:L14285) (333 aa) fasta scores: E(): 1.7e-18, 44.64% id in 168 aa;putative replication initiation protein (fragement) 282459012828 Similar to the C-terminal regions Staphylococcus aureus plasmid pC55s putative replication protein Rep TR:Q938S2 (EMBL:AY048756) (331 aa) fasta scores: E(): 1.8e-20, 63.63% id in 132 aa, and to Staphylococcus epidermidis Orf334 orf334 TR:Q53999 (EMBL:U15783) (334 aa) fasta scores: E(): 2e-20, 62.04% id in 137 aa;putative replication protein (fragment) 282459012829 Pfam match to entry PF01446 Rep, Replication protein, score -29.1, E-value 1e-08 282459012830 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 282459012831 Cadmium resistance transporter; Region: Cad; pfam03596 282459012832 6 probable transmembrane helices predicted for pSAS.11 by TMHMM2.0 at aa 10-32, 45-67, 72-91, 112-134, 138-160 and 181-203 282459012833 Pfam match to entry PF03596 Cad, Cadmium resistance transporter, score 434.5, E-value 5.8e-128 282459012834 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 282459012835 putative DNA binding site [nucleotide binding]; other site 282459012836 putative Zn2+ binding site [ion binding]; other site 282459012837 Pfam match to entry PF01022 HTH_5, Bacterial regulatory protein, arsR family, score 95.0, E-value 9e-26 282459012838 PS00846 Bacterial regulatory proteins, arsR family signature. 282459012839 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 282459012840 PS00392 DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. 282459012841 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 282459012842 PS00017 ATP/GTP-binding site motif A (P-loop). 282459012843 Similar to Staphylococcus aureus transposon Tn552 transposase SW:TRA3_STAAU (P18416) (480 aa) fasta scores: E(): 3.1e-176, 91.06% id in 481 aa, and to Listeria innocua plasmid pLI100 hypothetical protein Pli0058 TR:Q926K2 (EMBL:AL592102) (478 aa) fasta scores: E(): 3.5e-93, 49.58% id in 484 aa. Contains a frameshift after codon 207. Frameshift occurs at a poly C hexamer;putative transposase (pseudogene) 282459012844 Pfam match to entry PF00665 rve, Integrase core domain, score 106.6, E-value 3e-29 282459012845 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 282459012846 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 282459012847 catalytic residues [active] 282459012848 catalytic nucleophile [active] 282459012849 Presynaptic Site I dimer interface [polypeptide binding]; other site 282459012850 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 282459012851 Synaptic Flat tetramer interface [polypeptide binding]; other site 282459012852 Synaptic Site I dimer interface [polypeptide binding]; other site 282459012853 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 282459012854 DNA-binding interface [nucleotide binding]; DNA binding site 282459012855 Pfam match to entry PF02796 HTH_7, Helix-turn-helix domain of resolvase, score 72.4, E-value 5.9e-19 282459012856 Pfam match to entry PF00239 resolvase, Resolvase, N terminal domain, score 284.6, E-value 7.8e-83 282459012857 PS00398 Site-specific recombinases signature 2. 282459012858 PS00397 Site-specific recombinases active site. 282459012859 Predicted transcriptional regulator [Transcription]; Region: COG3682 282459012860 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 282459012861 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 282459012862 Pfam match to entry PF00144 beta-lactamase, Beta-lactamase, score 132.5, E-value 4.8e-37 282459012863 6 probable transmembrane helices predicted for pSAS.18c by TMHMM2.0 at aa 4-26, 38-60, 105-127, 165-187, 211-233 and 309-331 282459012864 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 282459012865 beta-lactamase TEM; Provisional; Region: PRK15442 282459012866 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 282459012867 Signal peptide predicted for pSAS.19 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 24 and 25 282459012868 Pfam match to entry PF00144 beta-lactamase, Beta-lactamase, score 376.1, E-value 2.2e-110 282459012869 PS00146 Beta-lactamase class-A active site. 282459012870 Similar to Staphylococcus aureus Tn552 transposable element potential DNA-invertase Bin3 SW:BIN3_STAAU (P20384) (202 aa) fasta scores: E(): 6.3e-33, 80.09% id in 201 aa, and to Staphylococcus epidermidis plasmid pST6 recombinase Sin TR:Q93SQ8 (EMBL:AY028779) (202 aa) fasta scores: E(): 1.5e-32, 78.71% id in 202 aa. CDS contains an internal deletion relative to orthologues;potential DNA-invertase (fragment) 282459012871 Pfam match to entry PF00239 resolvase, Resolvase, N terminal domain, score 165.5, E-value 5.5e-47 282459012872 PS00397 Site-specific recombinases active site. 282459012873 Pfam match to entry PF02796 HTH_7, Helix-turn-helix domain of resolvase, score 86.7, E-value 2.9e-23 282459012874 1 probable transmembrane helix predicted for pSAS.21 by TMHMM2.0 at aa 31-48 282459012875 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 282459012876 Signal peptide predicted for pSAS.22 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.966 between residues 28 and 29 282459012877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 282459012878 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 282459012879 8 probable transmembrane helices predicted for pSAS.23 by TMHMM2.0 at aa 7-25, 158-175, 204-226, 241-263, 276-298, 538-557, 578-600 and 610-632 282459012880 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 282459012881 Signal peptide predicted for pSAS.24 by SignalP 2.0 HMM (Signal peptide probabilty 0.953) with cleavage site probability 0.581 between residues 24 and 25