-- dump date 20140620_074502 -- class Genbank::misc_feature -- table misc_feature_note -- id note 196620000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 196620000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 196620000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620000004 Walker A motif; other site 196620000005 ATP binding site [chemical binding]; other site 196620000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 196620000007 Walker B motif; other site 196620000008 arginine finger; other site 196620000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 196620000010 DnaA box-binding interface [nucleotide binding]; other site 196620000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 196620000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 196620000013 putative DNA binding surface [nucleotide binding]; other site 196620000014 dimer interface [polypeptide binding]; other site 196620000015 beta-clamp/clamp loader binding surface; other site 196620000016 beta-clamp/translesion DNA polymerase binding surface; other site 196620000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 196620000018 recF protein; Region: recf; TIGR00611 196620000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 196620000020 Walker A/P-loop; other site 196620000021 ATP binding site [chemical binding]; other site 196620000022 Q-loop/lid; other site 196620000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196620000024 ABC transporter signature motif; other site 196620000025 Walker B; other site 196620000026 D-loop; other site 196620000027 H-loop/switch region; other site 196620000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 196620000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620000030 Mg2+ binding site [ion binding]; other site 196620000031 G-X-G motif; other site 196620000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 196620000033 anchoring element; other site 196620000034 dimer interface [polypeptide binding]; other site 196620000035 ATP binding site [chemical binding]; other site 196620000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 196620000037 active site 196620000038 putative metal-binding site [ion binding]; other site 196620000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 196620000040 DNA gyrase subunit A; Validated; Region: PRK05560 196620000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 196620000042 CAP-like domain; other site 196620000043 active site 196620000044 primary dimer interface [polypeptide binding]; other site 196620000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196620000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196620000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196620000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196620000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196620000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196620000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 196620000052 putative substrate binding site [chemical binding]; other site 196620000053 putative ATP binding site [chemical binding]; other site 196620000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 196620000055 active sites [active] 196620000056 tetramer interface [polypeptide binding]; other site 196620000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 196620000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 196620000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 196620000060 dimer interface [polypeptide binding]; other site 196620000061 active site 196620000062 motif 1; other site 196620000063 motif 2; other site 196620000064 motif 3; other site 196620000065 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 196620000066 Predicted membrane protein [Function unknown]; Region: COG4392 196620000067 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 196620000068 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 196620000069 Predicted membrane protein [Function unknown]; Region: COG4241 196620000070 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 196620000071 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 196620000072 DHH family; Region: DHH; pfam01368 196620000073 DHHA1 domain; Region: DHHA1; pfam02272 196620000074 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 196620000075 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 196620000076 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 196620000077 replicative DNA helicase; Region: DnaB; TIGR00665 196620000078 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 196620000079 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 196620000080 Walker A motif; other site 196620000081 ATP binding site [chemical binding]; other site 196620000082 Walker B motif; other site 196620000083 DNA binding loops [nucleotide binding] 196620000084 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 196620000085 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 196620000086 GDP-binding site [chemical binding]; other site 196620000087 ACT binding site; other site 196620000088 IMP binding site; other site 196620000089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196620000090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620000091 active site 196620000092 phosphorylation site [posttranslational modification] 196620000093 intermolecular recognition site; other site 196620000094 dimerization interface [polypeptide binding]; other site 196620000095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196620000096 DNA binding site [nucleotide binding] 196620000097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 196620000098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196620000099 dimerization interface [polypeptide binding]; other site 196620000100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 196620000101 putative active site [active] 196620000102 heme pocket [chemical binding]; other site 196620000103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196620000104 dimer interface [polypeptide binding]; other site 196620000105 phosphorylation site [posttranslational modification] 196620000106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620000107 ATP binding site [chemical binding]; other site 196620000108 Mg2+ binding site [ion binding]; other site 196620000109 G-X-G motif; other site 196620000110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 196620000111 YycH protein; Region: YycH; pfam07435 196620000112 YycH protein; Region: YycI; cl02015 196620000113 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 196620000114 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 196620000115 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 196620000116 putative active site [active] 196620000117 putative metal binding site [ion binding]; other site 196620000118 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 196620000119 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 196620000120 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 196620000121 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 196620000122 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 196620000123 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 196620000124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 196620000125 Integrase core domain; Region: rve; pfam00665 196620000126 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 196620000127 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 196620000128 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 196620000129 putative active site [active] 196620000130 catalytic site [active] 196620000131 putative metal binding site [ion binding]; other site 196620000132 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 196620000133 putative active site [active] 196620000134 putative catalytic site [active] 196620000135 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 196620000136 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 196620000137 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 196620000138 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 196620000139 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 196620000140 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 196620000141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 196620000142 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196620000143 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 196620000144 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 196620000145 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 196620000146 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 196620000147 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 196620000148 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 196620000149 catalytic residues [active] 196620000150 catalytic nucleophile [active] 196620000151 Presynaptic Site I dimer interface [polypeptide binding]; other site 196620000152 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 196620000153 Synaptic Flat tetramer interface [polypeptide binding]; other site 196620000154 Synaptic Site I dimer interface [polypeptide binding]; other site 196620000155 DNA binding site [nucleotide binding] 196620000156 Recombinase; Region: Recombinase; pfam07508 196620000157 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 196620000158 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 196620000159 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 196620000160 catalytic residues [active] 196620000161 catalytic nucleophile [active] 196620000162 Recombinase; Region: Recombinase; pfam07508 196620000163 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 196620000164 Domain of unknown function (DUF927); Region: DUF927; pfam06048 196620000165 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 196620000166 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 196620000167 Divergent AAA domain; Region: AAA_4; pfam04326 196620000168 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 196620000169 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196620000170 active site residue [active] 196620000171 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 196620000172 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196620000173 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196620000174 active site 196620000175 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 196620000176 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 196620000177 HTH-like domain; Region: HTH_21; pfam13276 196620000178 Integrase core domain; Region: rve; pfam00665 196620000179 Transposase; Region: HTH_Tnp_1; cl17663 196620000180 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 196620000181 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620000182 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620000183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620000184 Coenzyme A binding pocket [chemical binding]; other site 196620000185 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 196620000186 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 196620000187 putative homodimer interface [polypeptide binding]; other site 196620000188 putative homotetramer interface [polypeptide binding]; other site 196620000189 putative metal binding site [ion binding]; other site 196620000190 putative homodimer-homodimer interface [polypeptide binding]; other site 196620000191 putative allosteric switch controlling residues; other site 196620000192 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196620000193 active site residue [active] 196620000194 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 196620000195 CPxP motif; other site 196620000196 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 196620000197 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 196620000198 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 196620000199 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196620000200 active site residue [active] 196620000201 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 196620000202 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 196620000203 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 196620000204 FMN binding site [chemical binding]; other site 196620000205 active site 196620000206 catalytic residues [active] 196620000207 substrate binding site [chemical binding]; other site 196620000208 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 196620000209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620000210 H+ Antiporter protein; Region: 2A0121; TIGR00900 196620000211 putative substrate translocation pore; other site 196620000212 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 196620000213 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 196620000214 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 196620000215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196620000216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196620000217 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 196620000218 dimerization interface [polypeptide binding]; other site 196620000219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196620000220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196620000221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196620000222 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 196620000223 Part of AAA domain; Region: AAA_19; pfam13245 196620000224 AAA domain; Region: AAA_12; pfam13087 196620000225 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 196620000226 active site 196620000227 catalytic site [active] 196620000228 putative metal binding site [ion binding]; other site 196620000229 Protein of unknown function, DUF576; Region: DUF576; pfam04507 196620000230 Protein of unknown function, DUF576; Region: DUF576; pfam04507 196620000231 Protein of unknown function, DUF576; Region: DUF576; pfam04507 196620000232 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 196620000233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 196620000234 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 196620000235 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 196620000236 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 196620000237 metal binding site [ion binding]; metal-binding site 196620000238 dimer interface [polypeptide binding]; other site 196620000239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620000240 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196620000241 putative substrate translocation pore; other site 196620000242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620000243 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 196620000244 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 196620000245 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 196620000246 PhoU domain; Region: PhoU; pfam01895 196620000247 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 196620000248 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 196620000249 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 196620000250 L-lactate permease; Region: Lactate_perm; cl00701 196620000251 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 196620000252 B domain; Region: B; pfam02216 196620000253 B domain; Region: B; pfam02216 196620000254 B domain; Region: B; pfam02216 196620000255 B domain; Region: B; pfam02216 196620000256 B domain; Region: B; pfam02216 196620000257 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 196620000258 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 196620000259 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196620000260 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 196620000261 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196620000262 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 196620000263 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196620000264 ABC-ATPase subunit interface; other site 196620000265 dimer interface [polypeptide binding]; other site 196620000266 putative PBP binding regions; other site 196620000267 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 196620000268 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196620000269 ABC-ATPase subunit interface; other site 196620000270 dimer interface [polypeptide binding]; other site 196620000271 putative PBP binding regions; other site 196620000272 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 196620000273 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 196620000274 siderophore binding site; other site 196620000275 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 196620000276 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 196620000277 dimer interface [polypeptide binding]; other site 196620000278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620000279 catalytic residue [active] 196620000280 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 196620000281 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 196620000282 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 196620000283 IucA / IucC family; Region: IucA_IucC; pfam04183 196620000284 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 196620000285 drug efflux system protein MdtG; Provisional; Region: PRK09874 196620000286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620000287 putative substrate translocation pore; other site 196620000288 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 196620000289 IucA / IucC family; Region: IucA_IucC; pfam04183 196620000290 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 196620000291 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 196620000292 IucA / IucC family; Region: IucA_IucC; pfam04183 196620000293 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 196620000294 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 196620000295 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 196620000296 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 196620000297 dimer interface [polypeptide binding]; other site 196620000298 active site 196620000299 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196620000300 catalytic residues [active] 196620000301 substrate binding site [chemical binding]; other site 196620000302 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 196620000303 ParB-like nuclease domain; Region: ParBc; pfam02195 196620000304 acetoin reductase; Validated; Region: PRK08643 196620000305 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 196620000306 NAD binding site [chemical binding]; other site 196620000307 homotetramer interface [polypeptide binding]; other site 196620000308 homodimer interface [polypeptide binding]; other site 196620000309 active site 196620000310 substrate binding site [chemical binding]; other site 196620000311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196620000312 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 196620000313 NAD(P) binding site [chemical binding]; other site 196620000314 active site 196620000315 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 196620000316 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196620000317 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 196620000318 putative ADP-binding pocket [chemical binding]; other site 196620000319 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 196620000320 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 196620000321 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 196620000322 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 196620000323 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 196620000324 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 196620000325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196620000326 DNA-binding site [nucleotide binding]; DNA binding site 196620000327 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 196620000328 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 196620000329 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196620000330 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 196620000331 intersubunit interface [polypeptide binding]; other site 196620000332 active site 196620000333 catalytic residue [active] 196620000334 phosphopentomutase; Provisional; Region: PRK05362 196620000335 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 196620000336 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 196620000337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620000338 dimer interface [polypeptide binding]; other site 196620000339 conserved gate region; other site 196620000340 putative PBP binding loops; other site 196620000341 ABC-ATPase subunit interface; other site 196620000342 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 196620000343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620000344 dimer interface [polypeptide binding]; other site 196620000345 conserved gate region; other site 196620000346 ABC-ATPase subunit interface; other site 196620000347 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 196620000348 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 196620000349 Walker A/P-loop; other site 196620000350 ATP binding site [chemical binding]; other site 196620000351 Q-loop/lid; other site 196620000352 ABC transporter signature motif; other site 196620000353 Walker B; other site 196620000354 D-loop; other site 196620000355 H-loop/switch region; other site 196620000356 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 196620000357 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 196620000358 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 196620000359 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 196620000360 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 196620000361 active site 196620000362 metal binding site [ion binding]; metal-binding site 196620000363 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 196620000364 Replication initiation factor; Region: Rep_trans; pfam02486 196620000365 Transposase IS200 like; Region: Y1_Tnp; cl00848 196620000366 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 196620000367 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 196620000368 putative catalytic cysteine [active] 196620000369 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 196620000370 putative active site [active] 196620000371 metal binding site [ion binding]; metal-binding site 196620000372 Chain length determinant protein; Region: Wzz; cl15801 196620000373 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 196620000374 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 196620000375 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 196620000376 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 196620000377 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 196620000378 NAD(P) binding site [chemical binding]; other site 196620000379 homodimer interface [polypeptide binding]; other site 196620000380 substrate binding site [chemical binding]; other site 196620000381 active site 196620000382 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 196620000383 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 196620000384 NAD(P) binding site [chemical binding]; other site 196620000385 homodimer interface [polypeptide binding]; other site 196620000386 substrate binding site [chemical binding]; other site 196620000387 active site 196620000388 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 196620000389 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 196620000390 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 196620000391 putative NAD(P) binding site [chemical binding]; other site 196620000392 active site 196620000393 putative substrate binding site [chemical binding]; other site 196620000394 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 196620000395 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 196620000396 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 196620000397 active site 196620000398 homodimer interface [polypeptide binding]; other site 196620000399 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196620000400 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 196620000401 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 196620000402 trimer interface [polypeptide binding]; other site 196620000403 active site 196620000404 substrate binding site [chemical binding]; other site 196620000405 CoA binding site [chemical binding]; other site 196620000406 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 196620000407 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196620000408 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 196620000409 Bacterial sugar transferase; Region: Bac_transf; pfam02397 196620000410 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 196620000411 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 196620000412 putative NAD(P) binding site [chemical binding]; other site 196620000413 active site 196620000414 putative substrate binding site [chemical binding]; other site 196620000415 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 196620000416 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 196620000417 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 196620000418 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 196620000419 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 196620000420 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 196620000421 active site 196620000422 homodimer interface [polypeptide binding]; other site 196620000423 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 196620000424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 196620000425 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 196620000426 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 196620000427 NAD(P) binding site [chemical binding]; other site 196620000428 catalytic residues [active] 196620000429 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 196620000430 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 196620000431 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 196620000432 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 196620000433 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 196620000434 Walker A/P-loop; other site 196620000435 ATP binding site [chemical binding]; other site 196620000436 Q-loop/lid; other site 196620000437 ABC transporter signature motif; other site 196620000438 Walker B; other site 196620000439 D-loop; other site 196620000440 H-loop/switch region; other site 196620000441 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 196620000442 NMT1-like family; Region: NMT1_2; pfam13379 196620000443 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 196620000444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 196620000445 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 196620000446 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 196620000447 active site 196620000448 Uncharacterized conserved protein [Function unknown]; Region: COG5609 196620000449 formate dehydrogenase; Provisional; Region: PRK07574 196620000450 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 196620000451 dimerization interface [polypeptide binding]; other site 196620000452 ligand binding site [chemical binding]; other site 196620000453 NAD binding site [chemical binding]; other site 196620000454 catalytic site [active] 196620000455 putative transporter; Provisional; Region: PRK10054 196620000456 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 196620000457 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 196620000458 acyl-activating enzyme (AAE) consensus motif; other site 196620000459 AMP binding site [chemical binding]; other site 196620000460 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 196620000461 Condensation domain; Region: Condensation; pfam00668 196620000462 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 196620000463 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 196620000464 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 196620000465 acyl-activating enzyme (AAE) consensus motif; other site 196620000466 AMP binding site [chemical binding]; other site 196620000467 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 196620000468 thioester reductase domain; Region: Thioester-redct; TIGR01746 196620000469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196620000470 NAD(P) binding site [chemical binding]; other site 196620000471 active site 196620000472 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 196620000473 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 196620000474 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 196620000475 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 196620000476 nucleotide binding site [chemical binding]; other site 196620000477 N-acetyl-L-glutamate binding site [chemical binding]; other site 196620000478 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 196620000479 heterotetramer interface [polypeptide binding]; other site 196620000480 active site pocket [active] 196620000481 cleavage site 196620000482 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 196620000483 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 196620000484 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 196620000485 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196620000486 inhibitor-cofactor binding pocket; inhibition site 196620000487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620000488 catalytic residue [active] 196620000489 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 196620000490 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 196620000491 Isochorismatase family; Region: Isochorismatase; pfam00857 196620000492 catalytic triad [active] 196620000493 conserved cis-peptide bond; other site 196620000494 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 196620000495 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 196620000496 dimer interface [polypeptide binding]; other site 196620000497 PYR/PP interface [polypeptide binding]; other site 196620000498 TPP binding site [chemical binding]; other site 196620000499 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 196620000500 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 196620000501 TPP-binding site [chemical binding]; other site 196620000502 dimer interface [polypeptide binding]; other site 196620000503 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 196620000504 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 196620000505 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 196620000506 active site turn [active] 196620000507 phosphorylation site [posttranslational modification] 196620000508 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 196620000509 HPr interaction site; other site 196620000510 glycerol kinase (GK) interaction site [polypeptide binding]; other site 196620000511 active site 196620000512 phosphorylation site [posttranslational modification] 196620000513 Uncharacterized conserved protein [Function unknown]; Region: COG3589 196620000514 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 196620000515 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 196620000516 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 196620000517 putative active site [active] 196620000518 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 196620000519 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 196620000520 active site turn [active] 196620000521 phosphorylation site [posttranslational modification] 196620000522 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 196620000523 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 196620000524 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 196620000525 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 196620000526 putative active site [active] 196620000527 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 196620000528 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 196620000529 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196620000530 ATP binding site [chemical binding]; other site 196620000531 putative Mg++ binding site [ion binding]; other site 196620000532 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 196620000533 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196620000534 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 196620000535 Walker A/P-loop; other site 196620000536 ATP binding site [chemical binding]; other site 196620000537 Q-loop/lid; other site 196620000538 ABC transporter signature motif; other site 196620000539 Walker B; other site 196620000540 D-loop; other site 196620000541 H-loop/switch region; other site 196620000542 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 196620000543 FtsX-like permease family; Region: FtsX; pfam02687 196620000544 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 196620000545 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 196620000546 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 196620000547 Walker A/P-loop; other site 196620000548 ATP binding site [chemical binding]; other site 196620000549 Q-loop/lid; other site 196620000550 ABC transporter signature motif; other site 196620000551 Walker B; other site 196620000552 D-loop; other site 196620000553 H-loop/switch region; other site 196620000554 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 196620000555 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196620000556 Walker A/P-loop; other site 196620000557 ATP binding site [chemical binding]; other site 196620000558 Q-loop/lid; other site 196620000559 ABC transporter signature motif; other site 196620000560 Walker B; other site 196620000561 D-loop; other site 196620000562 H-loop/switch region; other site 196620000563 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 196620000564 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196620000565 Walker A/P-loop; other site 196620000566 ATP binding site [chemical binding]; other site 196620000567 Q-loop/lid; other site 196620000568 ABC transporter signature motif; other site 196620000569 Walker B; other site 196620000570 D-loop; other site 196620000571 H-loop/switch region; other site 196620000572 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 196620000573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620000574 dimer interface [polypeptide binding]; other site 196620000575 conserved gate region; other site 196620000576 putative PBP binding loops; other site 196620000577 ABC-ATPase subunit interface; other site 196620000578 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 196620000579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620000580 dimer interface [polypeptide binding]; other site 196620000581 conserved gate region; other site 196620000582 ABC-ATPase subunit interface; other site 196620000583 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 196620000584 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 196620000585 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 196620000586 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 196620000587 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 196620000588 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742 196620000589 azoreductase; Reviewed; Region: PRK00170 196620000590 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 196620000591 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 196620000592 Peptidase family M23; Region: Peptidase_M23; pfam01551 196620000593 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 196620000594 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 196620000595 Walker A/P-loop; other site 196620000596 ATP binding site [chemical binding]; other site 196620000597 Q-loop/lid; other site 196620000598 ABC transporter signature motif; other site 196620000599 Walker B; other site 196620000600 D-loop; other site 196620000601 H-loop/switch region; other site 196620000602 TOBE domain; Region: TOBE; pfam03459 196620000603 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 196620000604 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 196620000605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620000606 dimer interface [polypeptide binding]; other site 196620000607 conserved gate region; other site 196620000608 ABC-ATPase subunit interface; other site 196620000609 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 196620000610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620000611 dimer interface [polypeptide binding]; other site 196620000612 conserved gate region; other site 196620000613 putative PBP binding loops; other site 196620000614 ABC-ATPase subunit interface; other site 196620000615 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 196620000616 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 196620000617 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 196620000618 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 196620000619 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 196620000620 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 196620000621 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 196620000622 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 196620000623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 196620000624 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 196620000625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620000626 putative substrate translocation pore; other site 196620000627 Response regulator receiver domain; Region: Response_reg; pfam00072 196620000628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620000629 active site 196620000630 phosphorylation site [posttranslational modification] 196620000631 intermolecular recognition site; other site 196620000632 dimerization interface [polypeptide binding]; other site 196620000633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 196620000634 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 196620000635 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 196620000636 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 196620000637 Histidine kinase; Region: His_kinase; pfam06580 196620000638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620000639 ATP binding site [chemical binding]; other site 196620000640 Mg2+ binding site [ion binding]; other site 196620000641 G-X-G motif; other site 196620000642 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 196620000643 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 196620000644 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 196620000645 Pyruvate formate lyase 1; Region: PFL1; cd01678 196620000646 coenzyme A binding site [chemical binding]; other site 196620000647 active site 196620000648 catalytic residues [active] 196620000649 glycine loop; other site 196620000650 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 196620000651 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196620000652 FeS/SAM binding site; other site 196620000653 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 196620000654 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 196620000655 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 196620000656 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 196620000657 putative active site [active] 196620000658 catalytic site [active] 196620000659 putative metal binding site [ion binding]; other site 196620000660 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 196620000661 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 196620000662 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 196620000663 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 196620000664 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 196620000665 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 196620000666 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 196620000667 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 196620000668 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 196620000669 dimer interface [polypeptide binding]; other site 196620000670 active site 196620000671 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 196620000672 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 196620000673 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 196620000674 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 196620000675 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 196620000676 substrate binding site [chemical binding]; other site 196620000677 oxyanion hole (OAH) forming residues; other site 196620000678 trimer interface [polypeptide binding]; other site 196620000679 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 196620000680 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 196620000681 active site 196620000682 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 196620000683 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 196620000684 acyl-activating enzyme (AAE) consensus motif; other site 196620000685 AMP binding site [chemical binding]; other site 196620000686 active site 196620000687 CoA binding site [chemical binding]; other site 196620000688 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 196620000689 Coenzyme A transferase; Region: CoA_trans; smart00882 196620000690 Coenzyme A transferase; Region: CoA_trans; cl17247 196620000691 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 196620000692 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 196620000693 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 196620000694 Uncharacterized conserved protein [Function unknown]; Region: COG3189 196620000695 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 196620000696 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 196620000697 heme-binding site [chemical binding]; other site 196620000698 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 196620000699 FAD binding pocket [chemical binding]; other site 196620000700 FAD binding motif [chemical binding]; other site 196620000701 phosphate binding motif [ion binding]; other site 196620000702 beta-alpha-beta structure motif; other site 196620000703 NAD binding pocket [chemical binding]; other site 196620000704 Heme binding pocket [chemical binding]; other site 196620000705 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 196620000706 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 196620000707 tetramer (dimer of dimers) interface [polypeptide binding]; other site 196620000708 NAD binding site [chemical binding]; other site 196620000709 dimer interface [polypeptide binding]; other site 196620000710 substrate binding site [chemical binding]; other site 196620000711 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 196620000712 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 196620000713 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 196620000714 active site turn [active] 196620000715 phosphorylation site [posttranslational modification] 196620000716 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 196620000717 active site 196620000718 tetramer interface [polypeptide binding]; other site 196620000719 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 196620000720 Mga helix-turn-helix domain; Region: Mga; pfam05043 196620000721 PRD domain; Region: PRD; pfam00874 196620000722 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 196620000723 active site 196620000724 P-loop; other site 196620000725 phosphorylation site [posttranslational modification] 196620000726 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 196620000727 active site 196620000728 phosphorylation site [posttranslational modification] 196620000729 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 196620000730 active site 196620000731 phosphorylation site [posttranslational modification] 196620000732 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 196620000733 active site 196620000734 P-loop; other site 196620000735 phosphorylation site [posttranslational modification] 196620000736 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 196620000737 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 196620000738 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 196620000739 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 196620000740 putative NAD(P) binding site [chemical binding]; other site 196620000741 catalytic Zn binding site [ion binding]; other site 196620000742 structural Zn binding site [ion binding]; other site 196620000743 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 196620000744 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 196620000745 putative NAD(P) binding site [chemical binding]; other site 196620000746 catalytic Zn binding site [ion binding]; other site 196620000747 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 196620000748 substrate binding site; other site 196620000749 dimer interface; other site 196620000750 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 196620000751 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 196620000752 putative NAD(P) binding site [chemical binding]; other site 196620000753 putative catalytic Zn binding site [ion binding]; other site 196620000754 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 196620000755 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 196620000756 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 196620000757 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 196620000758 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 196620000759 substrate binding site; other site 196620000760 dimer interface; other site 196620000761 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 196620000762 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 196620000763 putative NAD(P) binding site [chemical binding]; other site 196620000764 putative catalytic Zn binding site [ion binding]; other site 196620000765 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 196620000766 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 196620000767 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 196620000768 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 196620000769 active site 196620000770 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 196620000771 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 196620000772 Hemerythrin-like domain; Region: Hr-like; cd12108 196620000773 Fe binding site [ion binding]; other site 196620000774 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 196620000775 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 196620000776 Histidine kinase; Region: His_kinase; pfam06580 196620000777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620000778 Mg2+ binding site [ion binding]; other site 196620000779 G-X-G motif; other site 196620000780 two-component response regulator; Provisional; Region: PRK14084 196620000781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620000782 active site 196620000783 phosphorylation site [posttranslational modification] 196620000784 intermolecular recognition site; other site 196620000785 dimerization interface [polypeptide binding]; other site 196620000786 LytTr DNA-binding domain; Region: LytTR; pfam04397 196620000787 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 196620000788 antiholin-like protein LrgB; Provisional; Region: PRK04288 196620000789 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 196620000790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196620000791 DNA-binding site [nucleotide binding]; DNA binding site 196620000792 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 196620000793 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 196620000794 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 196620000795 HPr interaction site; other site 196620000796 glycerol kinase (GK) interaction site [polypeptide binding]; other site 196620000797 active site 196620000798 phosphorylation site [posttranslational modification] 196620000799 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 196620000800 beta-galactosidase; Region: BGL; TIGR03356 196620000801 Methyltransferase domain; Region: Methyltransf_31; pfam13847 196620000802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620000803 S-adenosylmethionine binding site [chemical binding]; other site 196620000804 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 196620000805 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 196620000806 substrate binding site [chemical binding]; other site 196620000807 dimer interface [polypeptide binding]; other site 196620000808 ATP binding site [chemical binding]; other site 196620000809 D-ribose pyranase; Provisional; Region: PRK11797 196620000810 Sugar transport protein; Region: Sugar_transport; pfam06800 196620000811 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196620000812 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196620000813 DNA binding site [nucleotide binding] 196620000814 domain linker motif; other site 196620000815 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 196620000816 dimerization interface [polypeptide binding]; other site 196620000817 ligand binding site [chemical binding]; other site 196620000818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620000819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620000820 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 196620000821 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 196620000822 active site 196620000823 Surface antigen [General function prediction only]; Region: COG3942 196620000824 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 196620000825 Peptidase family M23; Region: Peptidase_M23; pfam01551 196620000826 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 196620000827 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 196620000828 Walker A/P-loop; other site 196620000829 ATP binding site [chemical binding]; other site 196620000830 Q-loop/lid; other site 196620000831 ABC transporter signature motif; other site 196620000832 Walker B; other site 196620000833 D-loop; other site 196620000834 H-loop/switch region; other site 196620000835 Surface antigen [General function prediction only]; Region: COG3942 196620000836 CHAP domain; Region: CHAP; pfam05257 196620000837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 196620000838 Predicted membrane protein [Function unknown]; Region: COG1511 196620000839 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 196620000840 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 196620000841 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 196620000842 Uncharacterized small protein [Function unknown]; Region: COG5417 196620000843 Predicted membrane protein [Function unknown]; Region: COG4499 196620000844 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 196620000845 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 196620000846 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 196620000847 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 196620000848 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 196620000849 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 196620000850 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 196620000851 Uncharacterized conserved protein [Function unknown]; Region: COG5444 196620000852 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 196620000853 Protein of unknown function, DUF600; Region: DUF600; cl04640 196620000854 Protein of unknown function, DUF600; Region: DUF600; cl04640 196620000855 Protein of unknown function, DUF600; Region: DUF600; cl04640 196620000856 Protein of unknown function, DUF600; Region: DUF600; cl04640 196620000857 Protein of unknown function, DUF600; Region: DUF600; cl04640 196620000858 Protein of unknown function, DUF600; Region: DUF600; cl04640 196620000859 Protein of unknown function, DUF600; Region: DUF600; cl04640 196620000860 Protein of unknown function, DUF600; Region: DUF600; cl04640 196620000861 Protein of unknown function, DUF600; Region: DUF600; cl04640 196620000862 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 196620000863 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 196620000864 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 196620000865 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 196620000866 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 196620000867 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 196620000868 FtsX-like permease family; Region: FtsX; pfam02687 196620000869 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196620000870 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 196620000871 Walker A/P-loop; other site 196620000872 ATP binding site [chemical binding]; other site 196620000873 Q-loop/lid; other site 196620000874 ABC transporter signature motif; other site 196620000875 Walker B; other site 196620000876 D-loop; other site 196620000877 H-loop/switch region; other site 196620000878 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 196620000879 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 196620000880 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196620000881 non-specific DNA binding site [nucleotide binding]; other site 196620000882 salt bridge; other site 196620000883 sequence-specific DNA binding site [nucleotide binding]; other site 196620000884 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 196620000885 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 196620000886 substrate binding site [chemical binding]; other site 196620000887 ATP binding site [chemical binding]; other site 196620000888 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 196620000889 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 196620000890 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 196620000891 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 196620000892 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 196620000893 putative transporter; Provisional; Region: PRK10484 196620000894 Na binding site [ion binding]; other site 196620000895 N-acetylneuraminate lyase; Provisional; Region: PRK04147 196620000896 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 196620000897 inhibitor site; inhibition site 196620000898 active site 196620000899 dimer interface [polypeptide binding]; other site 196620000900 catalytic residue [active] 196620000901 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 196620000902 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 196620000903 nucleotide binding site [chemical binding]; other site 196620000904 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 196620000905 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 196620000906 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 196620000907 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 196620000908 putative active site [active] 196620000909 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 196620000910 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 196620000911 putative active site cavity [active] 196620000912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 196620000913 Nucleoside recognition; Region: Gate; pfam07670 196620000914 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 196620000915 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 196620000916 PGAP1-like protein; Region: PGAP1; pfam07819 196620000917 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 196620000918 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 196620000919 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 196620000920 putative active site [active] 196620000921 putative FMN binding site [chemical binding]; other site 196620000922 putative substrate binding site [chemical binding]; other site 196620000923 putative catalytic residue [active] 196620000924 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 196620000925 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 196620000926 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 196620000927 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 196620000928 lipoyl attachment site [posttranslational modification]; other site 196620000929 Replication protein C N-terminal domain; Region: RP-C; pfam03428 196620000930 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 196620000931 putative ADP-ribose binding site [chemical binding]; other site 196620000932 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 196620000933 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 196620000934 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 196620000935 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 196620000936 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 196620000937 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 196620000938 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 196620000939 NADP binding site [chemical binding]; other site 196620000940 putative substrate binding site [chemical binding]; other site 196620000941 active site 196620000942 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 196620000943 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 196620000944 active site 196620000945 P-loop; other site 196620000946 phosphorylation site [posttranslational modification] 196620000947 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 196620000948 active site 196620000949 phosphorylation site [posttranslational modification] 196620000950 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 196620000951 HTH domain; Region: HTH_11; pfam08279 196620000952 HTH domain; Region: HTH_11; pfam08279 196620000953 PRD domain; Region: PRD; pfam00874 196620000954 PRD domain; Region: PRD; pfam00874 196620000955 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 196620000956 active site 196620000957 P-loop; other site 196620000958 phosphorylation site [posttranslational modification] 196620000959 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 196620000960 active site 196620000961 phosphorylation site [posttranslational modification] 196620000962 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 196620000963 MarR family; Region: MarR_2; pfam12802 196620000964 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 196620000965 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 196620000966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 196620000967 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 196620000968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620000969 putative substrate translocation pore; other site 196620000970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620000971 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 196620000972 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 196620000973 Zn binding site [ion binding]; other site 196620000974 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 196620000975 Zn binding site [ion binding]; other site 196620000976 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 196620000977 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 196620000978 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 196620000979 Predicted flavoprotein [General function prediction only]; Region: COG0431 196620000980 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 196620000981 Predicted membrane protein [Function unknown]; Region: COG2855 196620000982 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 196620000983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 196620000984 Imelysin; Region: Peptidase_M75; pfam09375 196620000985 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 196620000986 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 196620000987 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 196620000988 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 196620000989 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 196620000990 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 196620000991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196620000992 non-specific DNA binding site [nucleotide binding]; other site 196620000993 salt bridge; other site 196620000994 sequence-specific DNA binding site [nucleotide binding]; other site 196620000995 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 196620000996 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196620000997 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 196620000998 Walker A/P-loop; other site 196620000999 ATP binding site [chemical binding]; other site 196620001000 Q-loop/lid; other site 196620001001 ABC transporter signature motif; other site 196620001002 Walker B; other site 196620001003 D-loop; other site 196620001004 H-loop/switch region; other site 196620001005 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 196620001006 Predicted membrane protein [Function unknown]; Region: COG4292 196620001007 putative acyltransferase; Provisional; Region: PRK05790 196620001008 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 196620001009 dimer interface [polypeptide binding]; other site 196620001010 active site 196620001011 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 196620001012 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 196620001013 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 196620001014 THF binding site; other site 196620001015 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 196620001016 substrate binding site [chemical binding]; other site 196620001017 THF binding site; other site 196620001018 zinc-binding site [ion binding]; other site 196620001019 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 196620001020 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 196620001021 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 196620001022 FAD binding site [chemical binding]; other site 196620001023 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 196620001024 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 196620001025 homodimer interface [polypeptide binding]; other site 196620001026 substrate-cofactor binding pocket; other site 196620001027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620001028 catalytic residue [active] 196620001029 cystathionine gamma-synthase; Reviewed; Region: PRK08247 196620001030 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 196620001031 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196620001032 catalytic residue [active] 196620001033 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 196620001034 ParB-like nuclease domain; Region: ParB; smart00470 196620001035 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 196620001036 Mechanosensitive ion channel; Region: MS_channel; pfam00924 196620001037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 196620001038 GTP-binding protein YchF; Reviewed; Region: PRK09601 196620001039 YchF GTPase; Region: YchF; cd01900 196620001040 G1 box; other site 196620001041 GTP/Mg2+ binding site [chemical binding]; other site 196620001042 Switch I region; other site 196620001043 G2 box; other site 196620001044 Switch II region; other site 196620001045 G3 box; other site 196620001046 G4 box; other site 196620001047 G5 box; other site 196620001048 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 196620001049 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 196620001050 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 196620001051 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 196620001052 dimer interface [polypeptide binding]; other site 196620001053 ssDNA binding site [nucleotide binding]; other site 196620001054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 196620001055 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 196620001056 Abi-like protein; Region: Abi_2; pfam07751 196620001057 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620001058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 196620001059 Predicted membrane protein [Function unknown]; Region: COG3212 196620001060 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 196620001061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 196620001062 non-specific DNA binding site [nucleotide binding]; other site 196620001063 salt bridge; other site 196620001064 sequence-specific DNA binding site [nucleotide binding]; other site 196620001065 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 196620001066 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196620001067 catalytic core [active] 196620001068 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 196620001069 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 196620001070 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 196620001071 catalytic residue [active] 196620001072 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 196620001073 catalytic residues [active] 196620001074 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 196620001075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196620001076 peroxiredoxin; Region: AhpC; TIGR03137 196620001077 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 196620001078 dimer interface [polypeptide binding]; other site 196620001079 decamer (pentamer of dimers) interface [polypeptide binding]; other site 196620001080 catalytic triad [active] 196620001081 peroxidatic and resolving cysteines [active] 196620001082 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 196620001083 dimer interface [polypeptide binding]; other site 196620001084 FMN binding site [chemical binding]; other site 196620001085 NADPH bind site [chemical binding]; other site 196620001086 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 196620001087 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 196620001088 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196620001089 active site 196620001090 xanthine permease; Region: pbuX; TIGR03173 196620001091 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 196620001092 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 196620001093 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 196620001094 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 196620001095 active site 196620001096 GMP synthase; Reviewed; Region: guaA; PRK00074 196620001097 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 196620001098 AMP/PPi binding site [chemical binding]; other site 196620001099 candidate oxyanion hole; other site 196620001100 catalytic triad [active] 196620001101 potential glutamine specificity residues [chemical binding]; other site 196620001102 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 196620001103 ATP Binding subdomain [chemical binding]; other site 196620001104 Ligand Binding sites [chemical binding]; other site 196620001105 Dimerization subdomain; other site 196620001106 Abi-like protein; Region: Abi_2; pfam07751 196620001107 Protein of unknown function DUF262; Region: DUF262; pfam03235 196620001108 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 196620001109 Protein of unknown function (DUF523); Region: DUF523; pfam04463 196620001110 LabA_like proteins; Region: LabA_like; cd06167 196620001111 putative metal binding site [ion binding]; other site 196620001112 Uncharacterized conserved protein [Function unknown]; Region: COG1432 196620001113 Predicted membrane protein [Function unknown]; Region: COG3759 196620001114 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 196620001115 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 196620001116 NADP binding site [chemical binding]; other site 196620001117 superantigen-like protein; Reviewed; Region: PRK13037 196620001118 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 196620001119 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620001120 superantigen-like protein; Reviewed; Region: PRK13041 196620001121 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 196620001122 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620001123 superantigen-like protein; Reviewed; Region: PRK13335 196620001124 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 196620001125 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620001126 superantigen-like protein; Reviewed; Region: PRK13042 196620001127 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 196620001128 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620001129 superantigen-like protein 5; Reviewed; Region: PRK13035 196620001130 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 196620001131 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620001132 superantigen-like protein; Reviewed; Region: PRK13040 196620001133 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 196620001134 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620001135 superantigen-like protein 7; Reviewed; Region: PRK13346 196620001136 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 196620001137 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620001138 superantigen-like protein; Reviewed; Region: PRK13039 196620001139 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 196620001140 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620001141 superantigen-like protein; Reviewed; Region: PRK13345 196620001142 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 196620001143 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620001144 superantigen-like protein 5; Reviewed; Region: PRK13035 196620001145 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 196620001146 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620001147 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 196620001148 HsdM N-terminal domain; Region: HsdM_N; pfam12161 196620001149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620001150 S-adenosylmethionine binding site [chemical binding]; other site 196620001151 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 196620001152 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 196620001153 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 196620001154 superantigen-like protein; Reviewed; Region: PRK13036 196620001155 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 196620001156 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620001157 Protein of unknown function, DUF576; Region: DUF576; pfam04507 196620001158 Protein of unknown function, DUF576; Region: DUF576; pfam04507 196620001159 Protein of unknown function, DUF576; Region: DUF576; pfam04507 196620001160 Protein of unknown function, DUF576; Region: DUF576; pfam04507 196620001161 Protein of unknown function, DUF576; Region: DUF576; pfam04507 196620001162 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 196620001163 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 196620001164 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 196620001165 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 196620001166 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 196620001167 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 196620001168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 196620001169 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 196620001170 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 196620001171 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 196620001172 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 196620001173 active site 196620001174 Esterase/lipase [General function prediction only]; Region: COG1647 196620001175 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 196620001176 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 196620001177 Na2 binding site [ion binding]; other site 196620001178 putative substrate binding site 1 [chemical binding]; other site 196620001179 Na binding site 1 [ion binding]; other site 196620001180 putative substrate binding site 2 [chemical binding]; other site 196620001181 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 196620001182 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 196620001183 dimer interface [polypeptide binding]; other site 196620001184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620001185 catalytic residue [active] 196620001186 cystathionine beta-lyase; Provisional; Region: PRK07671 196620001187 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 196620001188 homodimer interface [polypeptide binding]; other site 196620001189 substrate-cofactor binding pocket; other site 196620001190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620001191 catalytic residue [active] 196620001192 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 196620001193 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 196620001194 Walker A/P-loop; other site 196620001195 ATP binding site [chemical binding]; other site 196620001196 Q-loop/lid; other site 196620001197 ABC transporter signature motif; other site 196620001198 Walker B; other site 196620001199 D-loop; other site 196620001200 H-loop/switch region; other site 196620001201 NIL domain; Region: NIL; pfam09383 196620001202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620001203 dimer interface [polypeptide binding]; other site 196620001204 conserved gate region; other site 196620001205 ABC-ATPase subunit interface; other site 196620001206 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 196620001207 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 196620001208 LysM domain; Region: LysM; pfam01476 196620001209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 196620001210 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 196620001211 Surface antigen [General function prediction only]; Region: COG3942 196620001212 CHAP domain; Region: CHAP; pfam05257 196620001213 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 196620001214 nudix motif; other site 196620001215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620001216 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 196620001217 Coenzyme A binding pocket [chemical binding]; other site 196620001218 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 196620001219 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 196620001220 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196620001221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196620001222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 196620001223 dimerization interface [polypeptide binding]; other site 196620001224 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 196620001225 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 196620001226 active site 196620001227 dimer interface [polypeptide binding]; other site 196620001228 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 196620001229 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 196620001230 active site 196620001231 FMN binding site [chemical binding]; other site 196620001232 substrate binding site [chemical binding]; other site 196620001233 3Fe-4S cluster binding site [ion binding]; other site 196620001234 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 196620001235 domain interface; other site 196620001236 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 196620001237 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 196620001238 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 196620001239 active site turn [active] 196620001240 phosphorylation site [posttranslational modification] 196620001241 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 196620001242 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 196620001243 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 196620001244 Ca binding site [ion binding]; other site 196620001245 active site 196620001246 catalytic site [active] 196620001247 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 196620001248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196620001249 DNA-binding site [nucleotide binding]; DNA binding site 196620001250 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 196620001251 UTRA domain; Region: UTRA; pfam07702 196620001252 similar to hypothetical protein 196620001253 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 196620001254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620001255 Coenzyme A binding pocket [chemical binding]; other site 196620001256 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 196620001257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620001258 Walker A motif; other site 196620001259 ATP binding site [chemical binding]; other site 196620001260 Walker B motif; other site 196620001261 arginine finger; other site 196620001262 hypothetical protein; Validated; Region: PRK00153 196620001263 recombination protein RecR; Reviewed; Region: recR; PRK00076 196620001264 RecR protein; Region: RecR; pfam02132 196620001265 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 196620001266 putative active site [active] 196620001267 putative metal-binding site [ion binding]; other site 196620001268 tetramer interface [polypeptide binding]; other site 196620001269 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 196620001270 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 196620001271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196620001272 catalytic residue [active] 196620001273 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 196620001274 thymidylate kinase; Validated; Region: tmk; PRK00698 196620001275 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 196620001276 TMP-binding site; other site 196620001277 ATP-binding site [chemical binding]; other site 196620001278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 196620001279 DNA polymerase III subunit delta'; Validated; Region: PRK08058 196620001280 DNA polymerase III subunit delta'; Validated; Region: PRK08485 196620001281 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 196620001282 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 196620001283 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 196620001284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620001285 S-adenosylmethionine binding site [chemical binding]; other site 196620001286 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 196620001287 GIY-YIG motif/motif A; other site 196620001288 putative active site [active] 196620001289 putative metal binding site [ion binding]; other site 196620001290 Predicted methyltransferases [General function prediction only]; Region: COG0313 196620001291 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 196620001292 putative SAM binding site [chemical binding]; other site 196620001293 putative homodimer interface [polypeptide binding]; other site 196620001294 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 196620001295 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 196620001296 active site 196620001297 HIGH motif; other site 196620001298 KMSKS motif; other site 196620001299 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 196620001300 tRNA binding surface [nucleotide binding]; other site 196620001301 anticodon binding site; other site 196620001302 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 196620001303 dimer interface [polypeptide binding]; other site 196620001304 putative tRNA-binding site [nucleotide binding]; other site 196620001305 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 196620001306 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 196620001307 active site 196620001308 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 196620001309 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 196620001310 putative active site [active] 196620001311 putative metal binding site [ion binding]; other site 196620001312 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 196620001313 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 196620001314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620001315 S-adenosylmethionine binding site [chemical binding]; other site 196620001316 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 196620001317 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 196620001318 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 196620001319 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 196620001320 pur operon repressor; Provisional; Region: PRK09213 196620001321 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 196620001322 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196620001323 active site 196620001324 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 196620001325 homotrimer interaction site [polypeptide binding]; other site 196620001326 putative active site [active] 196620001327 regulatory protein SpoVG; Reviewed; Region: PRK13259 196620001328 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 196620001329 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 196620001330 Substrate binding site; other site 196620001331 Mg++ binding site; other site 196620001332 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 196620001333 active site 196620001334 substrate binding site [chemical binding]; other site 196620001335 CoA binding site [chemical binding]; other site 196620001336 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 196620001337 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 196620001338 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196620001339 active site 196620001340 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 196620001341 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 196620001342 5S rRNA interface [nucleotide binding]; other site 196620001343 CTC domain interface [polypeptide binding]; other site 196620001344 L16 interface [polypeptide binding]; other site 196620001345 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 196620001346 putative active site [active] 196620001347 catalytic residue [active] 196620001348 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 196620001349 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 196620001350 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196620001351 ATP binding site [chemical binding]; other site 196620001352 putative Mg++ binding site [ion binding]; other site 196620001353 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196620001354 nucleotide binding region [chemical binding]; other site 196620001355 ATP-binding site [chemical binding]; other site 196620001356 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 196620001357 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 196620001358 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 196620001359 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 196620001360 putative SAM binding site [chemical binding]; other site 196620001361 putative homodimer interface [polypeptide binding]; other site 196620001362 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 196620001363 homodimer interface [polypeptide binding]; other site 196620001364 metal binding site [ion binding]; metal-binding site 196620001365 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196620001366 RNA binding surface [nucleotide binding]; other site 196620001367 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 196620001368 Septum formation initiator; Region: DivIC; pfam04977 196620001369 hypothetical protein; Provisional; Region: PRK08582 196620001370 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 196620001371 RNA binding site [nucleotide binding]; other site 196620001372 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 196620001373 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 196620001374 Ligand Binding Site [chemical binding]; other site 196620001375 TilS substrate C-terminal domain; Region: TilS_C; smart00977 196620001376 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 196620001377 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196620001378 active site 196620001379 FtsH Extracellular; Region: FtsH_ext; pfam06480 196620001380 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 196620001381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620001382 Walker A motif; other site 196620001383 ATP binding site [chemical binding]; other site 196620001384 Walker B motif; other site 196620001385 arginine finger; other site 196620001386 Peptidase family M41; Region: Peptidase_M41; pfam01434 196620001387 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 196620001388 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 196620001389 dimerization interface [polypeptide binding]; other site 196620001390 domain crossover interface; other site 196620001391 redox-dependent activation switch; other site 196620001392 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 196620001393 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 196620001394 dimer interface [polypeptide binding]; other site 196620001395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620001396 catalytic residue [active] 196620001397 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 196620001398 dihydropteroate synthase; Region: DHPS; TIGR01496 196620001399 substrate binding pocket [chemical binding]; other site 196620001400 dimer interface [polypeptide binding]; other site 196620001401 inhibitor binding site; inhibition site 196620001402 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 196620001403 homooctamer interface [polypeptide binding]; other site 196620001404 active site 196620001405 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 196620001406 catalytic center binding site [active] 196620001407 ATP binding site [chemical binding]; other site 196620001408 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 196620001409 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 196620001410 dimer interface [polypeptide binding]; other site 196620001411 putative anticodon binding site; other site 196620001412 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 196620001413 motif 1; other site 196620001414 active site 196620001415 motif 2; other site 196620001416 motif 3; other site 196620001417 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 196620001418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196620001419 DNA-binding site [nucleotide binding]; DNA binding site 196620001420 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196620001421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620001422 homodimer interface [polypeptide binding]; other site 196620001423 catalytic residue [active] 196620001424 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 196620001425 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 196620001426 active site 196620001427 multimer interface [polypeptide binding]; other site 196620001428 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 196620001429 predicted active site [active] 196620001430 catalytic triad [active] 196620001431 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 196620001432 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 196620001433 Nucleoside recognition; Region: Gate; pfam07670 196620001434 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 196620001435 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 196620001436 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 196620001437 UvrB/uvrC motif; Region: UVR; pfam02151 196620001438 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 196620001439 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 196620001440 ADP binding site [chemical binding]; other site 196620001441 phosphagen binding site; other site 196620001442 substrate specificity loop; other site 196620001443 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 196620001444 Clp amino terminal domain; Region: Clp_N; pfam02861 196620001445 Clp amino terminal domain; Region: Clp_N; pfam02861 196620001446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620001447 Walker A motif; other site 196620001448 ATP binding site [chemical binding]; other site 196620001449 Walker B motif; other site 196620001450 arginine finger; other site 196620001451 UvrB/uvrC motif; Region: UVR; pfam02151 196620001452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620001453 Walker A motif; other site 196620001454 ATP binding site [chemical binding]; other site 196620001455 Walker B motif; other site 196620001456 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 196620001457 DNA repair protein RadA; Provisional; Region: PRK11823 196620001458 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 196620001459 Walker A motif/ATP binding site; other site 196620001460 ATP binding site [chemical binding]; other site 196620001461 Walker B motif; other site 196620001462 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 196620001463 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 196620001464 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 196620001465 putative active site [active] 196620001466 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 196620001467 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 196620001468 active site 196620001469 HIGH motif; other site 196620001470 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 196620001471 active site 196620001472 KMSKS motif; other site 196620001473 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 196620001474 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 196620001475 trimer interface [polypeptide binding]; other site 196620001476 active site 196620001477 substrate binding site [chemical binding]; other site 196620001478 CoA binding site [chemical binding]; other site 196620001479 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 196620001480 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 196620001481 active site 196620001482 HIGH motif; other site 196620001483 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 196620001484 KMSKS motif; other site 196620001485 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 196620001486 tRNA binding surface [nucleotide binding]; other site 196620001487 anticodon binding site; other site 196620001488 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 196620001489 active site 196620001490 dimerization interface [polypeptide binding]; other site 196620001491 metal binding site [ion binding]; metal-binding site 196620001492 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 196620001493 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 196620001494 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 196620001495 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 196620001496 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 196620001497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196620001498 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 196620001499 DNA binding residues [nucleotide binding] 196620001500 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 196620001501 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 196620001502 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 196620001503 putative homodimer interface [polypeptide binding]; other site 196620001504 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 196620001505 heterodimer interface [polypeptide binding]; other site 196620001506 homodimer interface [polypeptide binding]; other site 196620001507 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 196620001508 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 196620001509 23S rRNA interface [nucleotide binding]; other site 196620001510 L7/L12 interface [polypeptide binding]; other site 196620001511 putative thiostrepton binding site; other site 196620001512 L25 interface [polypeptide binding]; other site 196620001513 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 196620001514 mRNA/rRNA interface [nucleotide binding]; other site 196620001515 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 196620001516 23S rRNA interface [nucleotide binding]; other site 196620001517 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 196620001518 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 196620001519 peripheral dimer interface [polypeptide binding]; other site 196620001520 core dimer interface [polypeptide binding]; other site 196620001521 L10 interface [polypeptide binding]; other site 196620001522 L11 interface [polypeptide binding]; other site 196620001523 putative EF-Tu interaction site [polypeptide binding]; other site 196620001524 putative EF-G interaction site [polypeptide binding]; other site 196620001525 Methyltransferase domain; Region: Methyltransf_31; pfam13847 196620001526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620001527 S-adenosylmethionine binding site [chemical binding]; other site 196620001528 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 196620001529 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 196620001530 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 196620001531 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 196620001532 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 196620001533 RPB10 interaction site [polypeptide binding]; other site 196620001534 RPB1 interaction site [polypeptide binding]; other site 196620001535 RPB11 interaction site [polypeptide binding]; other site 196620001536 RPB3 interaction site [polypeptide binding]; other site 196620001537 RPB12 interaction site [polypeptide binding]; other site 196620001538 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 196620001539 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 196620001540 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 196620001541 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 196620001542 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 196620001543 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 196620001544 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 196620001545 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 196620001546 G-loop; other site 196620001547 DNA binding site [nucleotide binding] 196620001548 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 196620001549 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 196620001550 S17 interaction site [polypeptide binding]; other site 196620001551 S8 interaction site; other site 196620001552 16S rRNA interaction site [nucleotide binding]; other site 196620001553 streptomycin interaction site [chemical binding]; other site 196620001554 23S rRNA interaction site [nucleotide binding]; other site 196620001555 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 196620001556 30S ribosomal protein S7; Validated; Region: PRK05302 196620001557 elongation factor G; Reviewed; Region: PRK00007 196620001558 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 196620001559 G1 box; other site 196620001560 putative GEF interaction site [polypeptide binding]; other site 196620001561 GTP/Mg2+ binding site [chemical binding]; other site 196620001562 Switch I region; other site 196620001563 G2 box; other site 196620001564 G3 box; other site 196620001565 Switch II region; other site 196620001566 G4 box; other site 196620001567 G5 box; other site 196620001568 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 196620001569 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 196620001570 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 196620001571 elongation factor Tu; Reviewed; Region: PRK00049 196620001572 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 196620001573 G1 box; other site 196620001574 GEF interaction site [polypeptide binding]; other site 196620001575 GTP/Mg2+ binding site [chemical binding]; other site 196620001576 Switch I region; other site 196620001577 G2 box; other site 196620001578 G3 box; other site 196620001579 Switch II region; other site 196620001580 G4 box; other site 196620001581 G5 box; other site 196620001582 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 196620001583 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 196620001584 Antibiotic Binding Site [chemical binding]; other site 196620001585 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 196620001586 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 196620001587 metal binding site [ion binding]; metal-binding site 196620001588 dimer interface [polypeptide binding]; other site 196620001589 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 196620001590 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 196620001591 substrate-cofactor binding pocket; other site 196620001592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620001593 catalytic residue [active] 196620001594 chaperone protein HchA; Provisional; Region: PRK04155 196620001595 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 196620001596 conserved cys residue [active] 196620001597 ribulokinase; Provisional; Region: PRK04123 196620001598 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 196620001599 N- and C-terminal domain interface [polypeptide binding]; other site 196620001600 active site 196620001601 MgATP binding site [chemical binding]; other site 196620001602 catalytic site [active] 196620001603 metal binding site [ion binding]; metal-binding site 196620001604 carbohydrate binding site [chemical binding]; other site 196620001605 homodimer interface [polypeptide binding]; other site 196620001606 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 196620001607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196620001608 NAD(P) binding site [chemical binding]; other site 196620001609 active site 196620001610 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 196620001611 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 196620001612 homodimer interface [polypeptide binding]; other site 196620001613 substrate-cofactor binding pocket; other site 196620001614 catalytic residue [active] 196620001615 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 196620001616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620001617 motif II; other site 196620001618 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 196620001619 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 196620001620 Substrate-binding site [chemical binding]; other site 196620001621 Substrate specificity [chemical binding]; other site 196620001622 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 196620001623 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 196620001624 Substrate-binding site [chemical binding]; other site 196620001625 Substrate specificity [chemical binding]; other site 196620001626 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 196620001627 nucleoside/Zn binding site; other site 196620001628 dimer interface [polypeptide binding]; other site 196620001629 catalytic motif [active] 196620001630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620001631 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 196620001632 active site 196620001633 motif I; other site 196620001634 motif II; other site 196620001635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620001636 Predicted flavoprotein [General function prediction only]; Region: COG0431 196620001637 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 196620001638 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 196620001639 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 196620001640 Cna protein B-type domain; Region: Cna_B; pfam05738 196620001641 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 196620001642 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 196620001643 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 196620001644 Cna protein B-type domain; Region: Cna_B; pfam05738 196620001645 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 196620001646 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 196620001647 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 196620001648 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 196620001649 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 196620001650 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 196620001651 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 196620001652 Cna protein B-type domain; Region: Cna_B; pfam05738 196620001653 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 196620001654 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 196620001655 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 196620001656 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196620001657 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 196620001658 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 196620001659 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196620001660 putative GTP cyclohydrolase; Provisional; Region: PRK13674 196620001661 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 196620001662 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 196620001663 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 196620001664 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 196620001665 active site 196620001666 trimer interface [polypeptide binding]; other site 196620001667 allosteric site; other site 196620001668 active site lid [active] 196620001669 hexamer (dimer of trimers) interface [polypeptide binding]; other site 196620001670 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 196620001671 active site 196620001672 dimer interface [polypeptide binding]; other site 196620001673 magnesium binding site [ion binding]; other site 196620001674 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 196620001675 tetramer interface [polypeptide binding]; other site 196620001676 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 196620001677 active site 196620001678 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 196620001679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620001680 motif II; other site 196620001681 proline/glycine betaine transporter; Provisional; Region: PRK10642 196620001682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620001683 putative substrate translocation pore; other site 196620001684 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 196620001685 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 196620001686 acyl-activating enzyme (AAE) consensus motif; other site 196620001687 AMP binding site [chemical binding]; other site 196620001688 active site 196620001689 CoA binding site [chemical binding]; other site 196620001690 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 196620001691 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 196620001692 dimer interface [polypeptide binding]; other site 196620001693 active site 196620001694 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 196620001695 dimer interface [polypeptide binding]; other site 196620001696 substrate binding site [chemical binding]; other site 196620001697 ATP binding site [chemical binding]; other site 196620001698 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 196620001699 ligand binding site [chemical binding]; other site 196620001700 active site 196620001701 UGI interface [polypeptide binding]; other site 196620001702 catalytic site [active] 196620001703 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 196620001704 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 196620001705 Uncharacterized conserved protein [Function unknown]; Region: COG3610 196620001706 Uncharacterized conserved protein [Function unknown]; Region: COG2966 196620001707 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 196620001708 putative heme peroxidase; Provisional; Region: PRK12276 196620001709 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 196620001710 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 196620001711 mevalonate kinase; Region: mevalon_kin; TIGR00549 196620001712 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 196620001713 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 196620001714 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 196620001715 diphosphomevalonate decarboxylase; Region: PLN02407 196620001716 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 196620001717 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 196620001718 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 196620001719 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 196620001720 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 196620001721 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 196620001722 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196620001723 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 196620001724 Predicted transcriptional regulator [Transcription]; Region: COG1959 196620001725 Transcriptional regulator; Region: Rrf2; pfam02082 196620001726 LXG domain of WXG superfamily; Region: LXG; pfam04740 196620001727 Protein of unknown function (DUF443); Region: DUF443; pfam04276 196620001728 Protein of unknown function (DUF443); Region: DUF443; pfam04276 196620001729 Protein of unknown function (DUF443); Region: DUF443; pfam04276 196620001730 Protein of unknown function (DUF443); Region: DUF443; pfam04276 196620001731 Protein of unknown function (DUF443); Region: DUF443; pfam04276 196620001732 Protein of unknown function (DUF443); Region: DUF443; pfam04276 196620001733 Protein of unknown function (DUF443); Region: DUF443; pfam04276 196620001734 Protein of unknown function (DUF443); Region: DUF443; pfam04276 196620001735 Protein of unknown function (DUF443); Region: DUF443; pfam04276 196620001736 Protein of unknown function (DUF443); Region: DUF443; pfam04276 196620001737 Protein of unknown function (DUF443); Region: DUF443; pfam04276 196620001738 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196620001739 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 196620001740 active site 196620001741 catalytic tetrad [active] 196620001742 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 196620001743 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 196620001744 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 196620001745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620001746 Coenzyme A binding pocket [chemical binding]; other site 196620001747 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 196620001748 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 196620001749 Zn2+ binding site [ion binding]; other site 196620001750 Mg2+ binding site [ion binding]; other site 196620001751 YwhD family; Region: YwhD; pfam08741 196620001752 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 196620001753 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 196620001754 NAD binding site [chemical binding]; other site 196620001755 substrate binding site [chemical binding]; other site 196620001756 catalytic Zn binding site [ion binding]; other site 196620001757 tetramer interface [polypeptide binding]; other site 196620001758 structural Zn binding site [ion binding]; other site 196620001759 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 196620001760 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 196620001761 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 196620001762 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 196620001763 active site 196620001764 HIGH motif; other site 196620001765 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196620001766 KMSK motif region; other site 196620001767 tRNA binding surface [nucleotide binding]; other site 196620001768 DALR anticodon binding domain; Region: DALR_1; smart00836 196620001769 anticodon binding site; other site 196620001770 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 196620001771 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 196620001772 minor groove reading motif; other site 196620001773 helix-hairpin-helix signature motif; other site 196620001774 substrate binding pocket [chemical binding]; other site 196620001775 active site 196620001776 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 196620001777 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 196620001778 putative binding site residues; other site 196620001779 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196620001780 ABC-ATPase subunit interface; other site 196620001781 dimer interface [polypeptide binding]; other site 196620001782 putative PBP binding regions; other site 196620001783 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 196620001784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620001785 motif II; other site 196620001786 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 196620001787 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 196620001788 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 196620001789 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 196620001790 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 196620001791 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196620001792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 196620001793 Protein of unknown function, DUF606; Region: DUF606; pfam04657 196620001794 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 196620001795 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 196620001796 active site 196620001797 DNA binding site [nucleotide binding] 196620001798 Int/Topo IB signature motif; other site 196620001799 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 196620001800 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 196620001801 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 196620001802 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 196620001803 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 196620001804 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 196620001805 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 196620001806 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 196620001807 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 196620001808 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 196620001809 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 196620001810 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 196620001811 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 196620001812 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 196620001813 metal binding site [ion binding]; metal-binding site 196620001814 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 196620001815 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196620001816 ABC-ATPase subunit interface; other site 196620001817 dimer interface [polypeptide binding]; other site 196620001818 putative PBP binding regions; other site 196620001819 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 196620001820 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 196620001821 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 196620001822 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 196620001823 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 196620001824 FeoA domain; Region: FeoA; pfam04023 196620001825 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 196620001826 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 196620001827 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 196620001828 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 196620001829 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 196620001830 Walker A/P-loop; other site 196620001831 ATP binding site [chemical binding]; other site 196620001832 Q-loop/lid; other site 196620001833 ABC transporter signature motif; other site 196620001834 Walker B; other site 196620001835 D-loop; other site 196620001836 H-loop/switch region; other site 196620001837 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 196620001838 ABC-2 type transporter; Region: ABC2_membrane; cl17235 196620001839 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 196620001840 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 196620001841 active site 196620001842 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196620001843 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 196620001844 active site 196620001845 nucleotide binding site [chemical binding]; other site 196620001846 HIGH motif; other site 196620001847 KMSKS motif; other site 196620001848 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 196620001849 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 196620001850 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 196620001851 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196620001852 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196620001853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196620001854 Walker A/P-loop; other site 196620001855 ATP binding site [chemical binding]; other site 196620001856 Q-loop/lid; other site 196620001857 ABC transporter signature motif; other site 196620001858 Walker B; other site 196620001859 D-loop; other site 196620001860 H-loop/switch region; other site 196620001861 similar to hypothetical protein 196620001862 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 196620001863 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 196620001864 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 196620001865 Uncharacterized conserved protein [Function unknown]; Region: COG1284 196620001866 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 196620001867 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 196620001868 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 196620001869 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196620001870 Walker A/P-loop; other site 196620001871 ATP binding site [chemical binding]; other site 196620001872 Q-loop/lid; other site 196620001873 ABC transporter signature motif; other site 196620001874 Walker B; other site 196620001875 D-loop; other site 196620001876 H-loop/switch region; other site 196620001877 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 196620001878 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196620001879 ABC-ATPase subunit interface; other site 196620001880 dimer interface [polypeptide binding]; other site 196620001881 putative PBP binding regions; other site 196620001882 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 196620001883 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196620001884 ABC-ATPase subunit interface; other site 196620001885 dimer interface [polypeptide binding]; other site 196620001886 putative PBP binding regions; other site 196620001887 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 196620001888 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 196620001889 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 196620001890 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 196620001891 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 196620001892 Uncharacterized membrane protein [Function unknown]; Region: COG3949 196620001893 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 196620001894 Na binding site [ion binding]; other site 196620001895 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 196620001896 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 196620001897 substrate binding pocket [chemical binding]; other site 196620001898 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 196620001899 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 196620001900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620001901 Coenzyme A binding pocket [chemical binding]; other site 196620001902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 196620001903 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 196620001904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196620001905 NAD(P) binding site [chemical binding]; other site 196620001906 active site 196620001907 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196620001908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620001909 active site 196620001910 phosphorylation site [posttranslational modification] 196620001911 intermolecular recognition site; other site 196620001912 dimerization interface [polypeptide binding]; other site 196620001913 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196620001914 DNA binding site [nucleotide binding] 196620001915 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 196620001916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 196620001917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620001918 ATP binding site [chemical binding]; other site 196620001919 Mg2+ binding site [ion binding]; other site 196620001920 G-X-G motif; other site 196620001921 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196620001922 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 196620001923 Walker A/P-loop; other site 196620001924 ATP binding site [chemical binding]; other site 196620001925 Q-loop/lid; other site 196620001926 ABC transporter signature motif; other site 196620001927 Walker B; other site 196620001928 D-loop; other site 196620001929 H-loop/switch region; other site 196620001930 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 196620001931 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 196620001932 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 196620001933 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 196620001934 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 196620001935 Surface antigen [General function prediction only]; Region: COG3942 196620001936 CHAP domain; Region: CHAP; pfam05257 196620001937 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 196620001938 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 196620001939 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 196620001940 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 196620001941 hypothetical protein; Provisional; Region: PRK12378 196620001942 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 196620001943 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 196620001944 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196620001945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196620001946 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 196620001947 dimerization interface [polypeptide binding]; other site 196620001948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620001949 sugar efflux transporter; Region: 2A0120; TIGR00899 196620001950 putative substrate translocation pore; other site 196620001951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 196620001952 Serine incorporator (Serinc); Region: Serinc; pfam03348 196620001953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620001954 Coenzyme A binding pocket [chemical binding]; other site 196620001955 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 196620001956 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 196620001957 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 196620001958 hypothetical protein; Validated; Region: PRK00124 196620001959 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 196620001960 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 196620001961 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 196620001962 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196620001963 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 196620001964 Walker A/P-loop; other site 196620001965 ATP binding site [chemical binding]; other site 196620001966 Q-loop/lid; other site 196620001967 ABC transporter signature motif; other site 196620001968 Walker B; other site 196620001969 D-loop; other site 196620001970 H-loop/switch region; other site 196620001971 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 196620001972 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196620001973 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 196620001974 Walker A/P-loop; other site 196620001975 ATP binding site [chemical binding]; other site 196620001976 Q-loop/lid; other site 196620001977 ABC transporter signature motif; other site 196620001978 Walker B; other site 196620001979 D-loop; other site 196620001980 H-loop/switch region; other site 196620001981 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196620001982 MarR family; Region: MarR; pfam01047 196620001983 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 196620001984 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 196620001985 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 196620001986 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196620001987 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 196620001988 active site 196620001989 catalytic tetrad [active] 196620001990 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 196620001991 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 196620001992 transmembrane helices; other site 196620001993 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 196620001994 DNA photolyase; Region: DNA_photolyase; pfam00875 196620001995 Predicted membrane protein [Function unknown]; Region: COG4330 196620001996 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 196620001997 trimer interface [polypeptide binding]; other site 196620001998 putative Zn binding site [ion binding]; other site 196620001999 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 196620002000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620002001 putative substrate translocation pore; other site 196620002002 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 196620002003 putative deacylase active site [active] 196620002004 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 196620002005 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 196620002006 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 196620002007 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 196620002008 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 196620002009 putative substrate binding site [chemical binding]; other site 196620002010 putative ATP binding site [chemical binding]; other site 196620002011 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 196620002012 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 196620002013 active site 196620002014 phosphorylation site [posttranslational modification] 196620002015 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 196620002016 active site 196620002017 P-loop; other site 196620002018 phosphorylation site [posttranslational modification] 196620002019 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 196620002020 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 196620002021 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 196620002022 active site 196620002023 dimer interface [polypeptide binding]; other site 196620002024 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 196620002025 Domain of unknown function DUF21; Region: DUF21; pfam01595 196620002026 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 196620002027 Transporter associated domain; Region: CorC_HlyC; pfam03471 196620002028 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196620002029 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 196620002030 active site 196620002031 catalytic tetrad [active] 196620002032 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 196620002033 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 196620002034 Ligand binding site; other site 196620002035 Putative Catalytic site; other site 196620002036 DXD motif; other site 196620002037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 196620002038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196620002039 dimer interface [polypeptide binding]; other site 196620002040 phosphorylation site [posttranslational modification] 196620002041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620002042 ATP binding site [chemical binding]; other site 196620002043 Mg2+ binding site [ion binding]; other site 196620002044 G-X-G motif; other site 196620002045 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196620002046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620002047 active site 196620002048 phosphorylation site [posttranslational modification] 196620002049 intermolecular recognition site; other site 196620002050 dimerization interface [polypeptide binding]; other site 196620002051 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196620002052 DNA binding site [nucleotide binding] 196620002053 Electron transfer DM13; Region: DM13; pfam10517 196620002054 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 196620002055 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 196620002056 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 196620002057 active site 196620002058 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 196620002059 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 196620002060 Ligand Binding Site [chemical binding]; other site 196620002061 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 196620002062 Glutamine amidotransferase class-I; Region: GATase; pfam00117 196620002063 glutamine binding [chemical binding]; other site 196620002064 catalytic triad [active] 196620002065 aminodeoxychorismate synthase; Provisional; Region: PRK07508 196620002066 chorismate binding enzyme; Region: Chorismate_bind; cl10555 196620002067 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 196620002068 substrate-cofactor binding pocket; other site 196620002069 Aminotransferase class IV; Region: Aminotran_4; pfam01063 196620002070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620002071 catalytic residue [active] 196620002072 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 196620002073 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 196620002074 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 196620002075 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 196620002076 Sulfatase; Region: Sulfatase; pfam00884 196620002077 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 196620002078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196620002079 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196620002080 ABC transporter; Region: ABC_tran_2; pfam12848 196620002081 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196620002082 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 196620002083 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196620002084 ATP binding site [chemical binding]; other site 196620002085 putative Mg++ binding site [ion binding]; other site 196620002086 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196620002087 nucleotide binding region [chemical binding]; other site 196620002088 ATP-binding site [chemical binding]; other site 196620002089 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 196620002090 HRDC domain; Region: HRDC; pfam00570 196620002091 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 196620002092 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 196620002093 Walker A/P-loop; other site 196620002094 ATP binding site [chemical binding]; other site 196620002095 Q-loop/lid; other site 196620002096 ABC transporter signature motif; other site 196620002097 Walker B; other site 196620002098 D-loop; other site 196620002099 H-loop/switch region; other site 196620002100 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 196620002101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620002102 dimer interface [polypeptide binding]; other site 196620002103 conserved gate region; other site 196620002104 ABC-ATPase subunit interface; other site 196620002105 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 196620002106 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 196620002107 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 196620002108 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196620002109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620002110 homodimer interface [polypeptide binding]; other site 196620002111 catalytic residue [active] 196620002112 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 196620002113 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 196620002114 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 196620002115 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 196620002116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620002117 putative substrate translocation pore; other site 196620002118 POT family; Region: PTR2; cl17359 196620002119 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 196620002120 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 196620002121 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 196620002122 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 196620002123 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 196620002124 Class I ribonucleotide reductase; Region: RNR_I; cd01679 196620002125 active site 196620002126 dimer interface [polypeptide binding]; other site 196620002127 catalytic residues [active] 196620002128 effector binding site; other site 196620002129 R2 peptide binding site; other site 196620002130 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 196620002131 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 196620002132 dimer interface [polypeptide binding]; other site 196620002133 putative radical transfer pathway; other site 196620002134 diiron center [ion binding]; other site 196620002135 tyrosyl radical; other site 196620002136 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196620002137 ABC-ATPase subunit interface; other site 196620002138 dimer interface [polypeptide binding]; other site 196620002139 putative PBP binding regions; other site 196620002140 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196620002141 ABC-ATPase subunit interface; other site 196620002142 dimer interface [polypeptide binding]; other site 196620002143 putative PBP binding regions; other site 196620002144 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 196620002145 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196620002146 Walker A/P-loop; other site 196620002147 ATP binding site [chemical binding]; other site 196620002148 Q-loop/lid; other site 196620002149 ABC transporter signature motif; other site 196620002150 Walker B; other site 196620002151 D-loop; other site 196620002152 H-loop/switch region; other site 196620002153 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 196620002154 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 196620002155 putative ligand binding residues [chemical binding]; other site 196620002156 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 196620002157 CHY zinc finger; Region: zf-CHY; pfam05495 196620002158 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 196620002159 FAD binding domain; Region: FAD_binding_4; pfam01565 196620002160 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 196620002161 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 196620002162 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 196620002163 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 196620002164 peptidase T; Region: peptidase-T; TIGR01882 196620002165 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 196620002166 metal binding site [ion binding]; metal-binding site 196620002167 dimer interface [polypeptide binding]; other site 196620002168 Uncharacterized conserved protein [Function unknown]; Region: COG3610 196620002169 Uncharacterized conserved protein [Function unknown]; Region: COG2966 196620002170 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 196620002171 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 196620002172 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 196620002173 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 196620002174 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 196620002175 metal binding site [ion binding]; metal-binding site 196620002176 active site 196620002177 I-site; other site 196620002178 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 196620002179 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 196620002180 Mg++ binding site [ion binding]; other site 196620002181 putative catalytic motif [active] 196620002182 substrate binding site [chemical binding]; other site 196620002183 Uncharacterized conserved protein [Function unknown]; Region: COG1739 196620002184 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 196620002185 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 196620002186 EDD domain protein, DegV family; Region: DegV; TIGR00762 196620002187 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 196620002188 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 196620002189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196620002190 ATP binding site [chemical binding]; other site 196620002191 putative Mg++ binding site [ion binding]; other site 196620002192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196620002193 nucleotide binding region [chemical binding]; other site 196620002194 ATP-binding site [chemical binding]; other site 196620002195 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 196620002196 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196620002197 active site 196620002198 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 196620002199 30S subunit binding site; other site 196620002200 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 196620002201 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 196620002202 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 196620002203 nucleotide binding region [chemical binding]; other site 196620002204 ATP-binding site [chemical binding]; other site 196620002205 SEC-C motif; Region: SEC-C; pfam02810 196620002206 This domain is found in peptide chain release factors; Region: PCRF; smart00937 196620002207 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 196620002208 RF-1 domain; Region: RF-1; pfam00472 196620002209 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 196620002210 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 196620002211 Surface antigen [General function prediction only]; Region: COG3942 196620002212 CHAP domain; Region: CHAP; pfam05257 196620002213 HD domain; Region: HD_3; cl17350 196620002214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 196620002215 excinuclease ABC subunit B; Provisional; Region: PRK05298 196620002216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196620002217 ATP binding site [chemical binding]; other site 196620002218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196620002219 nucleotide binding region [chemical binding]; other site 196620002220 ATP-binding site [chemical binding]; other site 196620002221 Ultra-violet resistance protein B; Region: UvrB; pfam12344 196620002222 UvrB/uvrC motif; Region: UVR; pfam02151 196620002223 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 196620002224 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 196620002225 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 196620002226 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 196620002227 HPr kinase/phosphorylase; Provisional; Region: PRK05428 196620002228 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 196620002229 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 196620002230 Hpr binding site; other site 196620002231 active site 196620002232 homohexamer subunit interaction site [polypeptide binding]; other site 196620002233 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 196620002234 putative acyl transferase; Provisional; Region: PRK10191 196620002235 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 196620002236 trimer interface [polypeptide binding]; other site 196620002237 active site 196620002238 substrate binding site [chemical binding]; other site 196620002239 CoA binding site [chemical binding]; other site 196620002240 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 196620002241 binding surface 196620002242 TPR motif; other site 196620002243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 196620002244 TPR motif; other site 196620002245 binding surface 196620002246 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 196620002247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 196620002248 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196620002249 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 196620002250 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 196620002251 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 196620002252 phosphate binding site [ion binding]; other site 196620002253 dimer interface [polypeptide binding]; other site 196620002254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 196620002255 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 196620002256 Clp protease; Region: CLP_protease; pfam00574 196620002257 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 196620002258 oligomer interface [polypeptide binding]; other site 196620002259 active site residues [active] 196620002260 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 196620002261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196620002262 NAD(P) binding site [chemical binding]; other site 196620002263 active site 196620002264 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 196620002265 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 196620002266 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 196620002267 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 196620002268 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 196620002269 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 196620002270 Phosphoglycerate kinase; Region: PGK; pfam00162 196620002271 substrate binding site [chemical binding]; other site 196620002272 hinge regions; other site 196620002273 ADP binding site [chemical binding]; other site 196620002274 catalytic site [active] 196620002275 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 196620002276 triosephosphate isomerase; Provisional; Region: PRK14565 196620002277 substrate binding site [chemical binding]; other site 196620002278 dimer interface [polypeptide binding]; other site 196620002279 catalytic triad [active] 196620002280 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 196620002281 phosphoglyceromutase; Provisional; Region: PRK05434 196620002282 enolase; Provisional; Region: eno; PRK00077 196620002283 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 196620002284 dimer interface [polypeptide binding]; other site 196620002285 metal binding site [ion binding]; metal-binding site 196620002286 substrate binding pocket [chemical binding]; other site 196620002287 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 196620002288 Esterase/lipase [General function prediction only]; Region: COG1647 196620002289 ribonuclease R; Region: RNase_R; TIGR02063 196620002290 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 196620002291 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 196620002292 RNB domain; Region: RNB; pfam00773 196620002293 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 196620002294 RNA binding site [nucleotide binding]; other site 196620002295 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 196620002296 SmpB-tmRNA interface; other site 196620002297 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 196620002298 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 196620002299 Int/Topo IB signature motif; other site 196620002300 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196620002301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196620002302 non-specific DNA binding site [nucleotide binding]; other site 196620002303 salt bridge; other site 196620002304 sequence-specific DNA binding site [nucleotide binding]; other site 196620002305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196620002306 salt bridge; other site 196620002307 non-specific DNA binding site [nucleotide binding]; other site 196620002308 sequence-specific DNA binding site [nucleotide binding]; other site 196620002309 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 196620002310 Uncharacterized conserved protein [Function unknown]; Region: COG4983 196620002311 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 196620002312 nucleotide binding site [chemical binding]; other site 196620002313 D5 N terminal like; Region: D5_N; smart00885 196620002314 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 196620002315 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 196620002316 Coat F domain; Region: Coat_F; cl17715 196620002317 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 196620002318 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620002319 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 196620002320 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620002321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620002322 Coenzyme A binding pocket [chemical binding]; other site 196620002323 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 196620002324 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 196620002325 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 196620002326 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 196620002327 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 196620002328 Staphylococcal nuclease homologues; Region: SNc; smart00318 196620002329 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 196620002330 Catalytic site; other site 196620002331 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 196620002332 DNA-binding site [nucleotide binding]; DNA binding site 196620002333 RNA-binding motif; other site 196620002334 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 196620002335 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 196620002336 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196620002337 catalytic core [active] 196620002338 Lysine efflux permease [General function prediction only]; Region: COG1279 196620002339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 196620002340 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 196620002341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 196620002342 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 196620002343 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 196620002344 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 196620002345 active site 196620002346 catalytic residue [active] 196620002347 dimer interface [polypeptide binding]; other site 196620002348 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 196620002349 putative FMN binding site [chemical binding]; other site 196620002350 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 196620002351 catalytic residues [active] 196620002352 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 196620002353 ArsC family; Region: ArsC; pfam03960 196620002354 putative ArsC-like catalytic residues; other site 196620002355 putative TRX-like catalytic residues [active] 196620002356 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 196620002357 lipoyl attachment site [posttranslational modification]; other site 196620002358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 196620002359 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 196620002360 putative active site [active] 196620002361 putative metal binding site [ion binding]; other site 196620002362 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 196620002363 catalytic residues [active] 196620002364 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 196620002365 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 196620002366 Walker A/P-loop; other site 196620002367 ATP binding site [chemical binding]; other site 196620002368 Q-loop/lid; other site 196620002369 ABC transporter signature motif; other site 196620002370 Walker B; other site 196620002371 D-loop; other site 196620002372 H-loop/switch region; other site 196620002373 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 196620002374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620002375 dimer interface [polypeptide binding]; other site 196620002376 conserved gate region; other site 196620002377 ABC-ATPase subunit interface; other site 196620002378 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 196620002379 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 196620002380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 196620002381 Predicted membrane protein [Function unknown]; Region: COG2035 196620002382 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 196620002383 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 196620002384 Walker A/P-loop; other site 196620002385 ATP binding site [chemical binding]; other site 196620002386 Q-loop/lid; other site 196620002387 ABC transporter signature motif; other site 196620002388 Walker B; other site 196620002389 D-loop; other site 196620002390 H-loop/switch region; other site 196620002391 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 196620002392 FeS assembly protein SufD; Region: sufD; TIGR01981 196620002393 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 196620002394 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 196620002395 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196620002396 catalytic residue [active] 196620002397 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 196620002398 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 196620002399 trimerization site [polypeptide binding]; other site 196620002400 active site 196620002401 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 196620002402 FeS assembly protein SufB; Region: sufB; TIGR01980 196620002403 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 196620002404 Domain of unknown function DUF21; Region: DUF21; pfam01595 196620002405 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 196620002406 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 196620002407 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 196620002408 FMN binding site [chemical binding]; other site 196620002409 substrate binding site [chemical binding]; other site 196620002410 putative catalytic residue [active] 196620002411 Uncharacterized conserved protein [Function unknown]; Region: COG1801 196620002412 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 196620002413 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 196620002414 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 196620002415 active site 196620002416 metal binding site [ion binding]; metal-binding site 196620002417 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 196620002418 lipoyl synthase; Provisional; Region: PRK05481 196620002419 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196620002420 FeS/SAM binding site; other site 196620002421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 196620002422 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 196620002423 Uncharacterized conserved protein [Function unknown]; Region: COG2445 196620002424 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 196620002425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620002426 active site 196620002427 motif I; other site 196620002428 motif II; other site 196620002429 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620002430 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 196620002431 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 196620002432 dimerization interface [polypeptide binding]; other site 196620002433 ligand binding site [chemical binding]; other site 196620002434 NADP binding site [chemical binding]; other site 196620002435 catalytic site [active] 196620002436 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 196620002437 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 196620002438 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 196620002439 acyl-activating enzyme (AAE) consensus motif; other site 196620002440 AMP binding site [chemical binding]; other site 196620002441 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 196620002442 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 196620002443 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 196620002444 DltD N-terminal region; Region: DltD_N; pfam04915 196620002445 DltD central region; Region: DltD_M; pfam04918 196620002446 DltD C-terminal region; Region: DltD_C; pfam04914 196620002447 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 196620002448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 196620002449 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 196620002450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196620002451 hypothetical protein; Provisional; Region: PRK13669 196620002452 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 196620002453 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 196620002454 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196620002455 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 196620002456 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 196620002457 interface (dimer of trimers) [polypeptide binding]; other site 196620002458 Substrate-binding/catalytic site; other site 196620002459 Zn-binding sites [ion binding]; other site 196620002460 Predicted permease [General function prediction only]; Region: COG2056 196620002461 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 196620002462 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 196620002463 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 196620002464 CoenzymeA binding site [chemical binding]; other site 196620002465 subunit interaction site [polypeptide binding]; other site 196620002466 PHB binding site; other site 196620002467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 196620002468 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 196620002469 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 196620002470 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 196620002471 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 196620002472 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 196620002473 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 196620002474 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 196620002475 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 196620002476 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 196620002477 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 196620002478 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 196620002479 Kinase associated protein B; Region: KapB; pfam08810 196620002480 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 196620002481 active site 196620002482 general stress protein 13; Validated; Region: PRK08059 196620002483 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 196620002484 RNA binding site [nucleotide binding]; other site 196620002485 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 196620002486 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 196620002487 putative active site [active] 196620002488 putative FMN binding site [chemical binding]; other site 196620002489 putative substrate binding site [chemical binding]; other site 196620002490 putative catalytic residue [active] 196620002491 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 196620002492 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196620002493 inhibitor-cofactor binding pocket; inhibition site 196620002494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620002495 catalytic residue [active] 196620002496 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 196620002497 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 196620002498 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 196620002499 NAD(P) binding site [chemical binding]; other site 196620002500 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 196620002501 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 196620002502 active site 196620002503 catalytic site [active] 196620002504 metal binding site [ion binding]; metal-binding site 196620002505 argininosuccinate lyase; Provisional; Region: PRK00855 196620002506 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 196620002507 active sites [active] 196620002508 tetramer interface [polypeptide binding]; other site 196620002509 argininosuccinate synthase; Provisional; Region: PRK13820 196620002510 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 196620002511 ANP binding site [chemical binding]; other site 196620002512 Substrate Binding Site II [chemical binding]; other site 196620002513 Substrate Binding Site I [chemical binding]; other site 196620002514 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 196620002515 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 196620002516 active site 196620002517 dimer interface [polypeptide binding]; other site 196620002518 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 196620002519 dimer interface [polypeptide binding]; other site 196620002520 active site 196620002521 Uncharacterized conserved protein [Function unknown]; Region: COG0398 196620002522 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 196620002523 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 196620002524 Catalytic site [active] 196620002525 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 196620002526 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 196620002527 Catalytic site [active] 196620002528 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 196620002529 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 196620002530 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 196620002531 Part of AAA domain; Region: AAA_19; pfam13245 196620002532 Family description; Region: UvrD_C_2; pfam13538 196620002533 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 196620002534 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 196620002535 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 196620002536 hypothetical protein; Provisional; Region: PRK13673 196620002537 coenzyme A disulfide reductase; Provisional; Region: PRK13512 196620002538 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 196620002539 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196620002540 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 196620002541 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 196620002542 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620002543 active site 196620002544 motif I; other site 196620002545 motif II; other site 196620002546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620002547 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 196620002548 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 196620002549 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 196620002550 catalytic triad [active] 196620002551 catalytic triad [active] 196620002552 oxyanion hole [active] 196620002553 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 196620002554 Clp amino terminal domain; Region: Clp_N; pfam02861 196620002555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620002556 Walker A motif; other site 196620002557 ATP binding site [chemical binding]; other site 196620002558 Walker B motif; other site 196620002559 arginine finger; other site 196620002560 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 196620002561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620002562 Walker A motif; other site 196620002563 ATP binding site [chemical binding]; other site 196620002564 Walker B motif; other site 196620002565 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 196620002566 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196620002567 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196620002568 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 196620002569 dimerization interface [polypeptide binding]; other site 196620002570 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 196620002571 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 196620002572 active site 196620002573 catalytic residues [active] 196620002574 metal binding site [ion binding]; metal-binding site 196620002575 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 196620002576 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 196620002577 substrate binding site [chemical binding]; other site 196620002578 MAP domain; Region: MAP; pfam03642 196620002579 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 196620002580 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 196620002581 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 196620002582 dimer interface [polypeptide binding]; other site 196620002583 active site 196620002584 CoA binding pocket [chemical binding]; other site 196620002585 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 196620002586 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 196620002587 dimer interface [polypeptide binding]; other site 196620002588 active site 196620002589 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 196620002590 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 196620002591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620002592 dimer interface [polypeptide binding]; other site 196620002593 conserved gate region; other site 196620002594 putative PBP binding loops; other site 196620002595 ABC-ATPase subunit interface; other site 196620002596 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 196620002597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620002598 dimer interface [polypeptide binding]; other site 196620002599 conserved gate region; other site 196620002600 putative PBP binding loops; other site 196620002601 ABC-ATPase subunit interface; other site 196620002602 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 196620002603 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196620002604 Walker A/P-loop; other site 196620002605 ATP binding site [chemical binding]; other site 196620002606 Q-loop/lid; other site 196620002607 ABC transporter signature motif; other site 196620002608 Walker B; other site 196620002609 D-loop; other site 196620002610 H-loop/switch region; other site 196620002611 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196620002612 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 196620002613 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196620002614 Walker A/P-loop; other site 196620002615 ATP binding site [chemical binding]; other site 196620002616 Q-loop/lid; other site 196620002617 ABC transporter signature motif; other site 196620002618 Walker B; other site 196620002619 D-loop; other site 196620002620 H-loop/switch region; other site 196620002621 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196620002622 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 196620002623 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 196620002624 peptide binding site [polypeptide binding]; other site 196620002625 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 196620002626 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 196620002627 peptide binding site [polypeptide binding]; other site 196620002628 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 196620002629 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196620002630 Walker A/P-loop; other site 196620002631 ATP binding site [chemical binding]; other site 196620002632 Q-loop/lid; other site 196620002633 ABC transporter signature motif; other site 196620002634 Walker B; other site 196620002635 D-loop; other site 196620002636 H-loop/switch region; other site 196620002637 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196620002638 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 196620002639 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196620002640 Walker A/P-loop; other site 196620002641 ATP binding site [chemical binding]; other site 196620002642 Q-loop/lid; other site 196620002643 ABC transporter signature motif; other site 196620002644 Walker B; other site 196620002645 D-loop; other site 196620002646 H-loop/switch region; other site 196620002647 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 196620002648 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 196620002649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620002650 dimer interface [polypeptide binding]; other site 196620002651 conserved gate region; other site 196620002652 putative PBP binding loops; other site 196620002653 ABC-ATPase subunit interface; other site 196620002654 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 196620002655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620002656 dimer interface [polypeptide binding]; other site 196620002657 conserved gate region; other site 196620002658 putative PBP binding loops; other site 196620002659 ABC-ATPase subunit interface; other site 196620002660 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 196620002661 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 196620002662 active site 196620002663 HIGH motif; other site 196620002664 dimer interface [polypeptide binding]; other site 196620002665 KMSKS motif; other site 196620002666 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 196620002667 ArsC family; Region: ArsC; pfam03960 196620002668 putative catalytic residues [active] 196620002669 thiol/disulfide switch; other site 196620002670 adaptor protein; Provisional; Region: PRK02315 196620002671 Competence protein CoiA-like family; Region: CoiA; cl11541 196620002672 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 196620002673 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 196620002674 active site 196620002675 Zn binding site [ion binding]; other site 196620002676 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 196620002677 Thioredoxin; Region: Thioredoxin_5; pfam13743 196620002678 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 196620002679 apolar tunnel; other site 196620002680 heme binding site [chemical binding]; other site 196620002681 dimerization interface [polypeptide binding]; other site 196620002682 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 196620002683 putative active site [active] 196620002684 putative metal binding residues [ion binding]; other site 196620002685 signature motif; other site 196620002686 putative triphosphate binding site [ion binding]; other site 196620002687 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 196620002688 synthetase active site [active] 196620002689 NTP binding site [chemical binding]; other site 196620002690 metal binding site [ion binding]; metal-binding site 196620002691 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 196620002692 ATP-NAD kinase; Region: NAD_kinase; pfam01513 196620002693 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 196620002694 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 196620002695 active site 196620002696 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 196620002697 MgtE intracellular N domain; Region: MgtE_N; smart00924 196620002698 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 196620002699 Divalent cation transporter; Region: MgtE; pfam01769 196620002700 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 196620002701 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 196620002702 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 196620002703 TrkA-N domain; Region: TrkA_N; pfam02254 196620002704 TrkA-C domain; Region: TrkA_C; pfam02080 196620002705 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 196620002706 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 196620002707 NAD binding site [chemical binding]; other site 196620002708 homotetramer interface [polypeptide binding]; other site 196620002709 homodimer interface [polypeptide binding]; other site 196620002710 substrate binding site [chemical binding]; other site 196620002711 active site 196620002712 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 196620002713 Domain of unknown function DUF20; Region: UPF0118; pfam01594 196620002714 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 196620002715 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 196620002716 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 196620002717 Putative esterase; Region: Esterase; pfam00756 196620002718 hypothetical protein; Provisional; Region: PRK13679 196620002719 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 196620002720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196620002721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620002722 putative substrate translocation pore; other site 196620002723 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 196620002724 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 196620002725 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 196620002726 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 196620002727 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 196620002728 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 196620002729 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 196620002730 YueH-like protein; Region: YueH; pfam14166 196620002731 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 196620002732 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 196620002733 G1 box; other site 196620002734 putative GEF interaction site [polypeptide binding]; other site 196620002735 GTP/Mg2+ binding site [chemical binding]; other site 196620002736 Switch I region; other site 196620002737 G2 box; other site 196620002738 G3 box; other site 196620002739 Switch II region; other site 196620002740 G4 box; other site 196620002741 G5 box; other site 196620002742 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 196620002743 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 196620002744 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 196620002745 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 196620002746 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 196620002747 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 196620002748 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 196620002749 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 196620002750 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 196620002751 active site 196620002752 metal binding site [ion binding]; metal-binding site 196620002753 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 196620002754 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 196620002755 IDEAL domain; Region: IDEAL; pfam08858 196620002756 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 196620002757 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 196620002758 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 196620002759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 196620002760 CAAX protease self-immunity; Region: Abi; pfam02517 196620002761 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 196620002762 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 196620002763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 196620002764 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 196620002765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 196620002766 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 196620002767 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 196620002768 Walker A/P-loop; other site 196620002769 ATP binding site [chemical binding]; other site 196620002770 Q-loop/lid; other site 196620002771 ABC transporter signature motif; other site 196620002772 Walker B; other site 196620002773 D-loop; other site 196620002774 H-loop/switch region; other site 196620002775 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 196620002776 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 196620002777 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196620002778 Predicted membrane protein [Function unknown]; Region: COG2259 196620002779 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 196620002780 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 196620002781 siderophore binding site; other site 196620002782 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 196620002783 Pertussis toxin, subunit 2 and 3, C-terminal domain; Region: Pertussis_S2S3; pfam02918 196620002784 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 196620002785 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 196620002786 UbiA prenyltransferase family; Region: UbiA; pfam01040 196620002787 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 196620002788 isochorismate synthases; Region: isochor_syn; TIGR00543 196620002789 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 196620002790 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 196620002791 dimer interface [polypeptide binding]; other site 196620002792 tetramer interface [polypeptide binding]; other site 196620002793 PYR/PP interface [polypeptide binding]; other site 196620002794 TPP binding site [chemical binding]; other site 196620002795 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 196620002796 TPP-binding site; other site 196620002797 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 196620002798 PGAP1-like protein; Region: PGAP1; pfam07819 196620002799 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 196620002800 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 196620002801 substrate binding site [chemical binding]; other site 196620002802 oxyanion hole (OAH) forming residues; other site 196620002803 trimer interface [polypeptide binding]; other site 196620002804 Staphostatin B; Region: Staphostatin_B; pfam09023 196620002805 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 196620002806 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 196620002807 aminotransferase A; Validated; Region: PRK07683 196620002808 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196620002809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620002810 homodimer interface [polypeptide binding]; other site 196620002811 catalytic residue [active] 196620002812 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 196620002813 Acyltransferase family; Region: Acyl_transf_3; pfam01757 196620002814 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 196620002815 MarR family; Region: MarR; pfam01047 196620002816 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 196620002817 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 196620002818 amidase catalytic site [active] 196620002819 Zn binding residues [ion binding]; other site 196620002820 substrate binding site [chemical binding]; other site 196620002821 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 196620002822 Lysozyme subfamily 2; Region: LYZ2; smart00047 196620002823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620002824 Coenzyme A binding pocket [chemical binding]; other site 196620002825 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 196620002826 Transcriptional regulator [Transcription]; Region: LytR; COG1316 196620002827 Beta-lactamase; Region: Beta-lactamase; pfam00144 196620002828 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 196620002829 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 196620002830 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 196620002831 Subunit I/III interface [polypeptide binding]; other site 196620002832 Subunit III/IV interface [polypeptide binding]; other site 196620002833 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 196620002834 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 196620002835 D-pathway; other site 196620002836 Putative ubiquinol binding site [chemical binding]; other site 196620002837 Low-spin heme (heme b) binding site [chemical binding]; other site 196620002838 Putative water exit pathway; other site 196620002839 Binuclear center (heme o3/CuB) [ion binding]; other site 196620002840 K-pathway; other site 196620002841 Putative proton exit pathway; other site 196620002842 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 196620002843 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 196620002844 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 196620002845 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 196620002846 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 196620002847 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 196620002848 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 196620002849 homodimer interface [polypeptide binding]; other site 196620002850 NADP binding site [chemical binding]; other site 196620002851 substrate binding site [chemical binding]; other site 196620002852 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 196620002853 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 196620002854 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 196620002855 NAD binding site [chemical binding]; other site 196620002856 ATP-grasp domain; Region: ATP-grasp; pfam02222 196620002857 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 196620002858 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 196620002859 ATP binding site [chemical binding]; other site 196620002860 active site 196620002861 substrate binding site [chemical binding]; other site 196620002862 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 196620002863 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 196620002864 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 196620002865 putative active site [active] 196620002866 catalytic triad [active] 196620002867 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 196620002868 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 196620002869 dimerization interface [polypeptide binding]; other site 196620002870 ATP binding site [chemical binding]; other site 196620002871 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 196620002872 dimerization interface [polypeptide binding]; other site 196620002873 ATP binding site [chemical binding]; other site 196620002874 amidophosphoribosyltransferase; Provisional; Region: PRK07272 196620002875 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 196620002876 active site 196620002877 tetramer interface [polypeptide binding]; other site 196620002878 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196620002879 active site 196620002880 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 196620002881 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 196620002882 dimerization interface [polypeptide binding]; other site 196620002883 putative ATP binding site [chemical binding]; other site 196620002884 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 196620002885 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 196620002886 active site 196620002887 substrate binding site [chemical binding]; other site 196620002888 cosubstrate binding site; other site 196620002889 catalytic site [active] 196620002890 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 196620002891 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 196620002892 purine monophosphate binding site [chemical binding]; other site 196620002893 dimer interface [polypeptide binding]; other site 196620002894 putative catalytic residues [active] 196620002895 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 196620002896 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 196620002897 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 196620002898 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 196620002899 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 196620002900 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 196620002901 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 196620002902 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 196620002903 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 196620002904 Walker A/P-loop; other site 196620002905 ATP binding site [chemical binding]; other site 196620002906 Q-loop/lid; other site 196620002907 ABC transporter signature motif; other site 196620002908 Walker B; other site 196620002909 D-loop; other site 196620002910 H-loop/switch region; other site 196620002911 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 196620002912 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 196620002913 Walker A/P-loop; other site 196620002914 ATP binding site [chemical binding]; other site 196620002915 Q-loop/lid; other site 196620002916 ABC transporter signature motif; other site 196620002917 Walker B; other site 196620002918 D-loop; other site 196620002919 H-loop/switch region; other site 196620002920 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 196620002921 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 196620002922 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 196620002923 putative RNA binding site [nucleotide binding]; other site 196620002924 Methyltransferase domain; Region: Methyltransf_26; pfam13659 196620002925 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 196620002926 dimerization domain swap beta strand [polypeptide binding]; other site 196620002927 regulatory protein interface [polypeptide binding]; other site 196620002928 active site 196620002929 regulatory phosphorylation site [posttranslational modification]; other site 196620002930 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 196620002931 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 196620002932 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 196620002933 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 196620002934 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 196620002935 catalytic residues [active] 196620002936 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 196620002937 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 196620002938 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 196620002939 TrkA-N domain; Region: TrkA_N; pfam02254 196620002940 TrkA-C domain; Region: TrkA_C; pfam02080 196620002941 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 196620002942 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 196620002943 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 196620002944 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 196620002945 hypothetical protein; Provisional; Region: PRK13667 196620002946 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 196620002947 active site 196620002948 catalytic residues [active] 196620002949 metal binding site [ion binding]; metal-binding site 196620002950 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 196620002951 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 196620002952 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 196620002953 TPP-binding site [chemical binding]; other site 196620002954 tetramer interface [polypeptide binding]; other site 196620002955 heterodimer interface [polypeptide binding]; other site 196620002956 phosphorylation loop region [posttranslational modification] 196620002957 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 196620002958 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 196620002959 alpha subunit interface [polypeptide binding]; other site 196620002960 TPP binding site [chemical binding]; other site 196620002961 heterodimer interface [polypeptide binding]; other site 196620002962 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 196620002963 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 196620002964 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 196620002965 E3 interaction surface; other site 196620002966 lipoyl attachment site [posttranslational modification]; other site 196620002967 e3 binding domain; Region: E3_binding; pfam02817 196620002968 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 196620002969 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 196620002970 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 196620002971 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196620002972 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 196620002973 hypothetical protein; Provisional; Region: PRK04387 196620002974 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196620002975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196620002976 non-specific DNA binding site [nucleotide binding]; other site 196620002977 salt bridge; other site 196620002978 sequence-specific DNA binding site [nucleotide binding]; other site 196620002979 Cupin domain; Region: Cupin_2; pfam07883 196620002980 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 196620002981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196620002982 Walker A/P-loop; other site 196620002983 ATP binding site [chemical binding]; other site 196620002984 Q-loop/lid; other site 196620002985 ABC transporter signature motif; other site 196620002986 Walker B; other site 196620002987 D-loop; other site 196620002988 H-loop/switch region; other site 196620002989 TOBE domain; Region: TOBE_2; pfam08402 196620002990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620002991 putative PBP binding loops; other site 196620002992 dimer interface [polypeptide binding]; other site 196620002993 ABC-ATPase subunit interface; other site 196620002994 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 196620002995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620002996 dimer interface [polypeptide binding]; other site 196620002997 conserved gate region; other site 196620002998 putative PBP binding loops; other site 196620002999 ABC-ATPase subunit interface; other site 196620003000 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 196620003001 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 196620003002 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 196620003003 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 196620003004 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 196620003005 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 196620003006 manganese transport protein MntH; Reviewed; Region: PRK00701 196620003007 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 196620003008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 196620003009 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 196620003010 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 196620003011 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 196620003012 active site 196620003013 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 196620003014 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 196620003015 G1 box; other site 196620003016 putative GEF interaction site [polypeptide binding]; other site 196620003017 GTP/Mg2+ binding site [chemical binding]; other site 196620003018 Switch I region; other site 196620003019 G2 box; other site 196620003020 G3 box; other site 196620003021 Switch II region; other site 196620003022 G4 box; other site 196620003023 G5 box; other site 196620003024 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 196620003025 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 196620003026 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 196620003027 hypothetical protein; Provisional; Region: PRK13666 196620003028 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 196620003029 pyruvate carboxylase; Reviewed; Region: PRK12999 196620003030 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 196620003031 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 196620003032 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 196620003033 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 196620003034 active site 196620003035 catalytic residues [active] 196620003036 metal binding site [ion binding]; metal-binding site 196620003037 homodimer binding site [polypeptide binding]; other site 196620003038 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 196620003039 carboxyltransferase (CT) interaction site; other site 196620003040 biotinylation site [posttranslational modification]; other site 196620003041 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 196620003042 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 196620003043 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 196620003044 UbiA prenyltransferase family; Region: UbiA; pfam01040 196620003045 Predicted membrane protein [Function unknown]; Region: COG2322 196620003046 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 196620003047 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 196620003048 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 196620003049 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 196620003050 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 196620003051 putative active site [active] 196620003052 catalytic site [active] 196620003053 putative metal binding site [ion binding]; other site 196620003054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 196620003055 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 196620003056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620003057 S-adenosylmethionine binding site [chemical binding]; other site 196620003058 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 196620003059 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 196620003060 active site 196620003061 (T/H)XGH motif; other site 196620003062 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 196620003063 hypothetical protein; Provisional; Region: PRK13670 196620003064 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 196620003065 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 196620003066 heme uptake protein IsdB; Region: IsdB; TIGR03657 196620003067 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 196620003068 NEAr Transporter domain; Region: NEAT; smart00725 196620003069 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 196620003070 heme-binding site [chemical binding]; other site 196620003071 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 196620003072 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 196620003073 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 196620003074 heme-binding site [chemical binding]; other site 196620003075 heme uptake protein IsdC; Region: IsdC; TIGR03656 196620003076 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 196620003077 heme-binding site [chemical binding]; other site 196620003078 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 196620003079 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 196620003080 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 196620003081 intersubunit interface [polypeptide binding]; other site 196620003082 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 196620003083 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196620003084 ABC-ATPase subunit interface; other site 196620003085 dimer interface [polypeptide binding]; other site 196620003086 putative PBP binding regions; other site 196620003087 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 196620003088 active site 196620003089 catalytic site [active] 196620003090 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 196620003091 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 196620003092 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 196620003093 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 196620003094 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 196620003095 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 196620003096 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 196620003097 dimer interface [polypeptide binding]; other site 196620003098 motif 1; other site 196620003099 active site 196620003100 motif 2; other site 196620003101 motif 3; other site 196620003102 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 196620003103 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 196620003104 putative tRNA-binding site [nucleotide binding]; other site 196620003105 B3/4 domain; Region: B3_4; pfam03483 196620003106 tRNA synthetase B5 domain; Region: B5; smart00874 196620003107 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 196620003108 dimer interface [polypeptide binding]; other site 196620003109 motif 1; other site 196620003110 motif 3; other site 196620003111 motif 2; other site 196620003112 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 196620003113 ribonuclease HIII; Provisional; Region: PRK00996 196620003114 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 196620003115 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 196620003116 RNA/DNA hybrid binding site [nucleotide binding]; other site 196620003117 active site 196620003118 Cell division protein ZapA; Region: ZapA; cl01146 196620003119 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 196620003120 Colicin V production protein; Region: Colicin_V; pfam02674 196620003121 hypothetical protein; Provisional; Region: PRK08609 196620003122 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 196620003123 active site 196620003124 primer binding site [nucleotide binding]; other site 196620003125 NTP binding site [chemical binding]; other site 196620003126 metal binding triad [ion binding]; metal-binding site 196620003127 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 196620003128 active site 196620003129 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 196620003130 MutS domain III; Region: MutS_III; pfam05192 196620003131 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 196620003132 Walker A/P-loop; other site 196620003133 ATP binding site [chemical binding]; other site 196620003134 Q-loop/lid; other site 196620003135 ABC transporter signature motif; other site 196620003136 Walker B; other site 196620003137 D-loop; other site 196620003138 H-loop/switch region; other site 196620003139 Smr domain; Region: Smr; pfam01713 196620003140 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 196620003141 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 196620003142 catalytic residues [active] 196620003143 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 196620003144 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 196620003145 GIY-YIG motif/motif A; other site 196620003146 active site 196620003147 catalytic site [active] 196620003148 putative DNA binding site [nucleotide binding]; other site 196620003149 metal binding site [ion binding]; metal-binding site 196620003150 UvrB/uvrC motif; Region: UVR; pfam02151 196620003151 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 196620003152 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 196620003153 putative Iron-sulfur protein interface [polypeptide binding]; other site 196620003154 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 196620003155 proximal heme binding site [chemical binding]; other site 196620003156 distal heme binding site [chemical binding]; other site 196620003157 putative dimer interface [polypeptide binding]; other site 196620003158 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 196620003159 L-aspartate oxidase; Provisional; Region: PRK06175 196620003160 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 196620003161 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 196620003162 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 196620003163 glutamate racemase; Provisional; Region: PRK00865 196620003164 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 196620003165 active site 196620003166 dimerization interface [polypeptide binding]; other site 196620003167 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 196620003168 active site 196620003169 metal binding site [ion binding]; metal-binding site 196620003170 homotetramer interface [polypeptide binding]; other site 196620003171 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 196620003172 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 196620003173 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 196620003174 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 196620003175 beta-channel forming cytolysin; Region: hlyII; TIGR01002 196620003176 superantigen-like protein; Reviewed; Region: PRK13350 196620003177 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620003178 superantigen-like protein; Reviewed; Region: PRK13349 196620003179 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620003180 superantigen-like protein; Reviewed; Region: PRK13043 196620003181 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620003182 ornithine carbamoyltransferase; Provisional; Region: PRK04284 196620003183 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 196620003184 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 196620003185 carbamate kinase; Reviewed; Region: PRK12686 196620003186 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 196620003187 putative substrate binding site [chemical binding]; other site 196620003188 nucleotide binding site [chemical binding]; other site 196620003189 nucleotide binding site [chemical binding]; other site 196620003190 homodimer interface [polypeptide binding]; other site 196620003191 Predicted membrane protein [Function unknown]; Region: COG1288 196620003192 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 196620003193 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 196620003194 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 196620003195 gating phenylalanine in ion channel; other site 196620003196 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 196620003197 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 196620003198 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 196620003199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620003200 motif II; other site 196620003201 hypothetical protein; Provisional; Region: PRK13688 196620003202 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 196620003203 Coenzyme A binding pocket [chemical binding]; other site 196620003204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 196620003205 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 196620003206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 196620003207 MraZ protein; Region: MraZ; pfam02381 196620003208 MraZ protein; Region: MraZ; pfam02381 196620003209 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 196620003210 MraW methylase family; Region: Methyltransf_5; pfam01795 196620003211 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 196620003212 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 196620003213 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 196620003214 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 196620003215 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 196620003216 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 196620003217 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 196620003218 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 196620003219 Mg++ binding site [ion binding]; other site 196620003220 putative catalytic motif [active] 196620003221 putative substrate binding site [chemical binding]; other site 196620003222 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 196620003223 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 196620003224 NAD binding site [chemical binding]; other site 196620003225 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 196620003226 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 196620003227 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 196620003228 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 196620003229 Cell division protein FtsQ; Region: FtsQ; pfam03799 196620003230 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 196620003231 Cell division protein FtsA; Region: FtsA; smart00842 196620003232 Cell division protein FtsA; Region: FtsA; pfam14450 196620003233 cell division protein FtsZ; Validated; Region: PRK09330 196620003234 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 196620003235 nucleotide binding site [chemical binding]; other site 196620003236 SulA interaction site; other site 196620003237 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 196620003238 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 196620003239 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 196620003240 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196620003241 catalytic residue [active] 196620003242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 196620003243 YGGT family; Region: YGGT; pfam02325 196620003244 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 196620003245 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196620003246 RNA binding surface [nucleotide binding]; other site 196620003247 DivIVA protein; Region: DivIVA; pfam05103 196620003248 DivIVA domain; Region: DivI1A_domain; TIGR03544 196620003249 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 196620003250 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 196620003251 HIGH motif; other site 196620003252 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 196620003253 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 196620003254 active site 196620003255 KMSKS motif; other site 196620003256 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 196620003257 tRNA binding surface [nucleotide binding]; other site 196620003258 anticodon binding site; other site 196620003259 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 196620003260 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 196620003261 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 196620003262 active site 196620003263 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 196620003264 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 196620003265 lipoprotein signal peptidase; Provisional; Region: PRK14787 196620003266 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 196620003267 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196620003268 RNA binding surface [nucleotide binding]; other site 196620003269 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 196620003270 active site 196620003271 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 196620003272 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 196620003273 uracil transporter; Provisional; Region: PRK10720 196620003274 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 196620003275 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 196620003276 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 196620003277 dihydroorotase; Validated; Region: pyrC; PRK09357 196620003278 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 196620003279 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 196620003280 active site 196620003281 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 196620003282 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 196620003283 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 196620003284 catalytic site [active] 196620003285 subunit interface [polypeptide binding]; other site 196620003286 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 196620003287 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 196620003288 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 196620003289 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 196620003290 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 196620003291 ATP-grasp domain; Region: ATP-grasp_4; cl17255 196620003292 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 196620003293 IMP binding site; other site 196620003294 dimer interface [polypeptide binding]; other site 196620003295 interdomain contacts; other site 196620003296 partial ornithine binding site; other site 196620003297 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 196620003298 active site 196620003299 dimer interface [polypeptide binding]; other site 196620003300 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196620003301 active site 196620003302 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 196620003303 dimer interface [polypeptide binding]; other site 196620003304 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 196620003305 Domain of unknown function (DUF814); Region: DUF814; pfam05670 196620003306 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 196620003307 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 196620003308 catalytic site [active] 196620003309 G-X2-G-X-G-K; other site 196620003310 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 196620003311 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 196620003312 Flavoprotein; Region: Flavoprotein; pfam02441 196620003313 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 196620003314 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 196620003315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196620003316 ATP binding site [chemical binding]; other site 196620003317 putative Mg++ binding site [ion binding]; other site 196620003318 helicase superfamily c-terminal domain; Region: HELICc; smart00490 196620003319 nucleotide binding region [chemical binding]; other site 196620003320 ATP-binding site [chemical binding]; other site 196620003321 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 196620003322 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 196620003323 active site 196620003324 catalytic residues [active] 196620003325 metal binding site [ion binding]; metal-binding site 196620003326 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 196620003327 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 196620003328 putative active site [active] 196620003329 substrate binding site [chemical binding]; other site 196620003330 putative cosubstrate binding site; other site 196620003331 catalytic site [active] 196620003332 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 196620003333 substrate binding site [chemical binding]; other site 196620003334 16S rRNA methyltransferase B; Provisional; Region: PRK14902 196620003335 NusB family; Region: NusB; pfam01029 196620003336 putative RNA binding site [nucleotide binding]; other site 196620003337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620003338 S-adenosylmethionine binding site [chemical binding]; other site 196620003339 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 196620003340 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196620003341 FeS/SAM binding site; other site 196620003342 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 196620003343 Protein phosphatase 2C; Region: PP2C; pfam00481 196620003344 active site 196620003345 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 196620003346 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 196620003347 active site 196620003348 ATP binding site [chemical binding]; other site 196620003349 substrate binding site [chemical binding]; other site 196620003350 activation loop (A-loop); other site 196620003351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 196620003352 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196620003353 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196620003354 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196620003355 Predicted GTPases [General function prediction only]; Region: COG1162 196620003356 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 196620003357 RNA binding site [nucleotide binding]; other site 196620003358 homodimer interface [polypeptide binding]; other site 196620003359 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 196620003360 GTPase/Zn-binding domain interface [polypeptide binding]; other site 196620003361 GTP/Mg2+ binding site [chemical binding]; other site 196620003362 G4 box; other site 196620003363 G5 box; other site 196620003364 G1 box; other site 196620003365 Switch I region; other site 196620003366 G2 box; other site 196620003367 G3 box; other site 196620003368 Switch II region; other site 196620003369 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 196620003370 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 196620003371 substrate binding site [chemical binding]; other site 196620003372 hexamer interface [polypeptide binding]; other site 196620003373 metal binding site [ion binding]; metal-binding site 196620003374 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 196620003375 Thiamine pyrophosphokinase; Region: TPK; cd07995 196620003376 active site 196620003377 dimerization interface [polypeptide binding]; other site 196620003378 thiamine binding site [chemical binding]; other site 196620003379 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 196620003380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 196620003381 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 196620003382 DAK2 domain; Region: Dak2; pfam02734 196620003383 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 196620003384 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 196620003385 generic binding surface II; other site 196620003386 ssDNA binding site; other site 196620003387 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196620003388 ATP binding site [chemical binding]; other site 196620003389 putative Mg++ binding site [ion binding]; other site 196620003390 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196620003391 nucleotide binding region [chemical binding]; other site 196620003392 ATP-binding site [chemical binding]; other site 196620003393 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 196620003394 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 196620003395 active site 2 [active] 196620003396 active site 1 [active] 196620003397 putative phosphate acyltransferase; Provisional; Region: PRK05331 196620003398 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 196620003399 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 196620003400 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 196620003401 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 196620003402 NAD(P) binding site [chemical binding]; other site 196620003403 homotetramer interface [polypeptide binding]; other site 196620003404 homodimer interface [polypeptide binding]; other site 196620003405 active site 196620003406 acyl carrier protein; Provisional; Region: acpP; PRK00982 196620003407 ribonuclease III; Reviewed; Region: rnc; PRK00102 196620003408 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 196620003409 dimerization interface [polypeptide binding]; other site 196620003410 active site 196620003411 metal binding site [ion binding]; metal-binding site 196620003412 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 196620003413 dsRNA binding site [nucleotide binding]; other site 196620003414 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 196620003415 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 196620003416 Walker A/P-loop; other site 196620003417 ATP binding site [chemical binding]; other site 196620003418 Q-loop/lid; other site 196620003419 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 196620003420 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 196620003421 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 196620003422 ABC transporter signature motif; other site 196620003423 Walker B; other site 196620003424 D-loop; other site 196620003425 H-loop/switch region; other site 196620003426 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 196620003427 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 196620003428 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 196620003429 P loop; other site 196620003430 GTP binding site [chemical binding]; other site 196620003431 putative DNA-binding protein; Validated; Region: PRK00118 196620003432 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 196620003433 signal recognition particle protein; Provisional; Region: PRK10867 196620003434 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 196620003435 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 196620003436 P loop; other site 196620003437 GTP binding site [chemical binding]; other site 196620003438 Signal peptide binding domain; Region: SRP_SPB; pfam02978 196620003439 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 196620003440 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 196620003441 RimM N-terminal domain; Region: RimM; pfam01782 196620003442 PRC-barrel domain; Region: PRC; pfam05239 196620003443 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 196620003444 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 196620003445 Predicted membrane protein [Function unknown]; Region: COG4485 196620003446 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 196620003447 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 196620003448 GTP/Mg2+ binding site [chemical binding]; other site 196620003449 G4 box; other site 196620003450 G5 box; other site 196620003451 G1 box; other site 196620003452 Switch I region; other site 196620003453 G2 box; other site 196620003454 G3 box; other site 196620003455 Switch II region; other site 196620003456 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 196620003457 RNA/DNA hybrid binding site [nucleotide binding]; other site 196620003458 active site 196620003459 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 196620003460 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 196620003461 CoA-ligase; Region: Ligase_CoA; pfam00549 196620003462 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 196620003463 CoA binding domain; Region: CoA_binding; pfam02629 196620003464 CoA-ligase; Region: Ligase_CoA; pfam00549 196620003465 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 196620003466 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 196620003467 CHAP domain; Region: CHAP; pfam05257 196620003468 FemAB family; Region: FemAB; pfam02388 196620003469 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 196620003470 DNA protecting protein DprA; Region: dprA; TIGR00732 196620003471 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 196620003472 DNA topoisomerase I; Validated; Region: PRK05582 196620003473 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 196620003474 active site 196620003475 interdomain interaction site; other site 196620003476 putative metal-binding site [ion binding]; other site 196620003477 nucleotide binding site [chemical binding]; other site 196620003478 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 196620003479 domain I; other site 196620003480 DNA binding groove [nucleotide binding] 196620003481 phosphate binding site [ion binding]; other site 196620003482 domain II; other site 196620003483 domain III; other site 196620003484 nucleotide binding site [chemical binding]; other site 196620003485 catalytic site [active] 196620003486 domain IV; other site 196620003487 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 196620003488 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 196620003489 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 196620003490 Glucose inhibited division protein A; Region: GIDA; pfam01134 196620003491 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 196620003492 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 196620003493 active site 196620003494 DNA binding site [nucleotide binding] 196620003495 Int/Topo IB signature motif; other site 196620003496 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 196620003497 active site 196620003498 HslU subunit interaction site [polypeptide binding]; other site 196620003499 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 196620003500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620003501 Walker A motif; other site 196620003502 ATP binding site [chemical binding]; other site 196620003503 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 196620003504 Walker B motif; other site 196620003505 arginine finger; other site 196620003506 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 196620003507 transcriptional repressor CodY; Validated; Region: PRK04158 196620003508 CodY GAF-like domain; Region: CodY; pfam06018 196620003509 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 196620003510 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 196620003511 rRNA interaction site [nucleotide binding]; other site 196620003512 S8 interaction site; other site 196620003513 putative laminin-1 binding site; other site 196620003514 elongation factor Ts; Provisional; Region: tsf; PRK09377 196620003515 UBA/TS-N domain; Region: UBA; pfam00627 196620003516 Elongation factor TS; Region: EF_TS; pfam00889 196620003517 Elongation factor TS; Region: EF_TS; pfam00889 196620003518 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 196620003519 putative nucleotide binding site [chemical binding]; other site 196620003520 uridine monophosphate binding site [chemical binding]; other site 196620003521 homohexameric interface [polypeptide binding]; other site 196620003522 ribosome recycling factor; Reviewed; Region: frr; PRK00083 196620003523 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 196620003524 hinge region; other site 196620003525 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 196620003526 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 196620003527 catalytic residue [active] 196620003528 putative FPP diphosphate binding site; other site 196620003529 putative FPP binding hydrophobic cleft; other site 196620003530 dimer interface [polypeptide binding]; other site 196620003531 putative IPP diphosphate binding site; other site 196620003532 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 196620003533 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 196620003534 RIP metalloprotease RseP; Region: TIGR00054 196620003535 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 196620003536 active site 196620003537 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 196620003538 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 196620003539 protein binding site [polypeptide binding]; other site 196620003540 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 196620003541 putative substrate binding region [chemical binding]; other site 196620003542 prolyl-tRNA synthetase; Provisional; Region: PRK09194 196620003543 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 196620003544 dimer interface [polypeptide binding]; other site 196620003545 motif 1; other site 196620003546 active site 196620003547 motif 2; other site 196620003548 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 196620003549 putative deacylase active site [active] 196620003550 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 196620003551 active site 196620003552 motif 3; other site 196620003553 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 196620003554 anticodon binding site; other site 196620003555 DNA polymerase III PolC; Validated; Region: polC; PRK00448 196620003556 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 196620003557 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 196620003558 generic binding surface II; other site 196620003559 generic binding surface I; other site 196620003560 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 196620003561 active site 196620003562 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 196620003563 active site 196620003564 catalytic site [active] 196620003565 substrate binding site [chemical binding]; other site 196620003566 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 196620003567 ribosome maturation protein RimP; Reviewed; Region: PRK00092 196620003568 Sm and related proteins; Region: Sm_like; cl00259 196620003569 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 196620003570 putative oligomer interface [polypeptide binding]; other site 196620003571 putative RNA binding site [nucleotide binding]; other site 196620003572 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 196620003573 NusA N-terminal domain; Region: NusA_N; pfam08529 196620003574 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 196620003575 RNA binding site [nucleotide binding]; other site 196620003576 homodimer interface [polypeptide binding]; other site 196620003577 NusA-like KH domain; Region: KH_5; pfam13184 196620003578 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 196620003579 G-X-X-G motif; other site 196620003580 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 196620003581 putative RNA binding cleft [nucleotide binding]; other site 196620003582 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 196620003583 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 196620003584 translation initiation factor IF-2; Region: IF-2; TIGR00487 196620003585 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 196620003586 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 196620003587 G1 box; other site 196620003588 putative GEF interaction site [polypeptide binding]; other site 196620003589 GTP/Mg2+ binding site [chemical binding]; other site 196620003590 Switch I region; other site 196620003591 G2 box; other site 196620003592 G3 box; other site 196620003593 Switch II region; other site 196620003594 G4 box; other site 196620003595 G5 box; other site 196620003596 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 196620003597 Translation-initiation factor 2; Region: IF-2; pfam11987 196620003598 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 196620003599 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 196620003600 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 196620003601 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 196620003602 RNA binding site [nucleotide binding]; other site 196620003603 active site 196620003604 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 196620003605 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 196620003606 active site 196620003607 Riboflavin kinase; Region: Flavokinase; smart00904 196620003608 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 196620003609 16S/18S rRNA binding site [nucleotide binding]; other site 196620003610 S13e-L30e interaction site [polypeptide binding]; other site 196620003611 25S rRNA binding site [nucleotide binding]; other site 196620003612 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 196620003613 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 196620003614 RNase E interface [polypeptide binding]; other site 196620003615 trimer interface [polypeptide binding]; other site 196620003616 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 196620003617 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 196620003618 RNase E interface [polypeptide binding]; other site 196620003619 trimer interface [polypeptide binding]; other site 196620003620 active site 196620003621 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 196620003622 putative nucleic acid binding region [nucleotide binding]; other site 196620003623 G-X-X-G motif; other site 196620003624 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 196620003625 RNA binding site [nucleotide binding]; other site 196620003626 domain interface; other site 196620003627 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 196620003628 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 196620003629 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 196620003630 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 196620003631 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 196620003632 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 196620003633 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 196620003634 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 196620003635 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 196620003636 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 196620003637 DNA-binding site [nucleotide binding]; DNA binding site 196620003638 UTRA domain; Region: UTRA; pfam07702 196620003639 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 196620003640 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 196620003641 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 196620003642 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 196620003643 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 196620003644 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 196620003645 classical (c) SDRs; Region: SDR_c; cd05233 196620003646 NAD(P) binding site [chemical binding]; other site 196620003647 active site 196620003648 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 196620003649 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 196620003650 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 196620003651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196620003652 non-specific DNA binding site [nucleotide binding]; other site 196620003653 salt bridge; other site 196620003654 sequence-specific DNA binding site [nucleotide binding]; other site 196620003655 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 196620003656 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 196620003657 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 196620003658 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 196620003659 putative MPT binding site; other site 196620003660 recombinase A; Provisional; Region: recA; PRK09354 196620003661 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 196620003662 hexamer interface [polypeptide binding]; other site 196620003663 Walker A motif; other site 196620003664 ATP binding site [chemical binding]; other site 196620003665 Walker B motif; other site 196620003666 phosphodiesterase; Provisional; Region: PRK12704 196620003667 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 196620003668 Zn2+ binding site [ion binding]; other site 196620003669 Mg2+ binding site [ion binding]; other site 196620003670 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 196620003671 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 196620003672 putative active site [active] 196620003673 metal binding site [ion binding]; metal-binding site 196620003674 homodimer binding site [polypeptide binding]; other site 196620003675 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 196620003676 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 196620003677 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 196620003678 dimer interface [polypeptide binding]; other site 196620003679 PYR/PP interface [polypeptide binding]; other site 196620003680 TPP binding site [chemical binding]; other site 196620003681 substrate binding site [chemical binding]; other site 196620003682 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 196620003683 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 196620003684 TPP-binding site [chemical binding]; other site 196620003685 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 196620003686 Uncharacterized conserved protein [Function unknown]; Region: COG0011 196620003687 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 196620003688 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 196620003689 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196620003690 FeS/SAM binding site; other site 196620003691 TRAM domain; Region: TRAM; pfam01938 196620003692 Predicted membrane protein [Function unknown]; Region: COG4550 196620003693 Predicted membrane protein [Function unknown]; Region: COG4732 196620003694 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 196620003695 MutS domain I; Region: MutS_I; pfam01624 196620003696 MutS domain II; Region: MutS_II; pfam05188 196620003697 MutS domain III; Region: MutS_III; pfam05192 196620003698 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 196620003699 Walker A/P-loop; other site 196620003700 ATP binding site [chemical binding]; other site 196620003701 Q-loop/lid; other site 196620003702 ABC transporter signature motif; other site 196620003703 Walker B; other site 196620003704 D-loop; other site 196620003705 H-loop/switch region; other site 196620003706 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 196620003707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620003708 ATP binding site [chemical binding]; other site 196620003709 Mg2+ binding site [ion binding]; other site 196620003710 G-X-G motif; other site 196620003711 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 196620003712 ATP binding site [chemical binding]; other site 196620003713 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 196620003714 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 196620003715 similar to hypothetical protein 196620003716 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 196620003717 amphipathic channel; other site 196620003718 Asn-Pro-Ala signature motifs; other site 196620003719 glycerol kinase; Provisional; Region: glpK; PRK00047 196620003720 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 196620003721 N- and C-terminal domain interface [polypeptide binding]; other site 196620003722 active site 196620003723 MgATP binding site [chemical binding]; other site 196620003724 catalytic site [active] 196620003725 metal binding site [ion binding]; metal-binding site 196620003726 glycerol binding site [chemical binding]; other site 196620003727 homotetramer interface [polypeptide binding]; other site 196620003728 homodimer interface [polypeptide binding]; other site 196620003729 FBP binding site [chemical binding]; other site 196620003730 protein IIAGlc interface [polypeptide binding]; other site 196620003731 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 196620003732 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 196620003733 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 196620003734 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 196620003735 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 196620003736 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 196620003737 bacterial Hfq-like; Region: Hfq; cd01716 196620003738 hexamer interface [polypeptide binding]; other site 196620003739 Sm1 motif; other site 196620003740 RNA binding site [nucleotide binding]; other site 196620003741 Sm2 motif; other site 196620003742 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 196620003743 catalytic residues [active] 196620003744 dimer interface [polypeptide binding]; other site 196620003745 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 196620003746 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 196620003747 HflX GTPase family; Region: HflX; cd01878 196620003748 G1 box; other site 196620003749 GTP/Mg2+ binding site [chemical binding]; other site 196620003750 Switch I region; other site 196620003751 G2 box; other site 196620003752 G3 box; other site 196620003753 Switch II region; other site 196620003754 G4 box; other site 196620003755 G5 box; other site 196620003756 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 196620003757 Aluminium resistance protein; Region: Alum_res; pfam06838 196620003758 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 196620003759 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 196620003760 DNA binding residues [nucleotide binding] 196620003761 putative dimer interface [polypeptide binding]; other site 196620003762 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 196620003763 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 196620003764 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 196620003765 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 196620003766 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 196620003767 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196620003768 catalytic residue [active] 196620003769 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 196620003770 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 196620003771 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 196620003772 putative active site [active] 196620003773 catalytic site [active] 196620003774 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 196620003775 putative active site [active] 196620003776 catalytic site [active] 196620003777 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196620003778 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 196620003779 Walker A/P-loop; other site 196620003780 ATP binding site [chemical binding]; other site 196620003781 Q-loop/lid; other site 196620003782 ABC transporter signature motif; other site 196620003783 Walker B; other site 196620003784 D-loop; other site 196620003785 H-loop/switch region; other site 196620003786 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 196620003787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 196620003788 Histidine kinase; Region: HisKA_3; pfam07730 196620003789 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 196620003790 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196620003791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620003792 active site 196620003793 phosphorylation site [posttranslational modification] 196620003794 intermolecular recognition site; other site 196620003795 dimerization interface [polypeptide binding]; other site 196620003796 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196620003797 DNA binding residues [nucleotide binding] 196620003798 dimerization interface [polypeptide binding]; other site 196620003799 Staphylococcal nuclease homologues; Region: SNc; smart00318 196620003800 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 196620003801 Catalytic site; other site 196620003802 AAA domain; Region: AAA_11; pfam13086 196620003803 aspartate kinase; Reviewed; Region: PRK09034 196620003804 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 196620003805 putative catalytic residues [active] 196620003806 putative nucleotide binding site [chemical binding]; other site 196620003807 putative aspartate binding site [chemical binding]; other site 196620003808 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 196620003809 allosteric regulatory residue; other site 196620003810 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 196620003811 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 196620003812 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 196620003813 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 196620003814 threonine synthase; Reviewed; Region: PRK06721 196620003815 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 196620003816 homodimer interface [polypeptide binding]; other site 196620003817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620003818 catalytic residue [active] 196620003819 homoserine kinase; Provisional; Region: PRK01212 196620003820 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 196620003821 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 196620003822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620003823 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 196620003824 active site 196620003825 motif I; other site 196620003826 motif II; other site 196620003827 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 196620003828 lysine transporter; Provisional; Region: PRK10836 196620003829 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 196620003830 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 196620003831 tetramer interface [polypeptide binding]; other site 196620003832 heme binding pocket [chemical binding]; other site 196620003833 NADPH binding site [chemical binding]; other site 196620003834 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 196620003835 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 196620003836 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 196620003837 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 196620003838 active site 196620003839 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 196620003840 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 196620003841 LexA repressor; Validated; Region: PRK00215 196620003842 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196620003843 putative DNA binding site [nucleotide binding]; other site 196620003844 putative Zn2+ binding site [ion binding]; other site 196620003845 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 196620003846 Catalytic site [active] 196620003847 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 196620003848 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 196620003849 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 196620003850 TPP-binding site [chemical binding]; other site 196620003851 dimer interface [polypeptide binding]; other site 196620003852 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 196620003853 PYR/PP interface [polypeptide binding]; other site 196620003854 dimer interface [polypeptide binding]; other site 196620003855 TPP binding site [chemical binding]; other site 196620003856 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 196620003857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 196620003858 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 196620003859 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 196620003860 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 196620003861 active site 196620003862 metal binding site [ion binding]; metal-binding site 196620003863 DNA binding site [nucleotide binding] 196620003864 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 196620003865 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 196620003866 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 196620003867 Walker A/P-loop; other site 196620003868 ATP binding site [chemical binding]; other site 196620003869 Q-loop/lid; other site 196620003870 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 196620003871 ABC transporter signature motif; other site 196620003872 Walker B; other site 196620003873 D-loop; other site 196620003874 H-loop/switch region; other site 196620003875 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 196620003876 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 196620003877 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 196620003878 aconitate hydratase; Validated; Region: PRK09277 196620003879 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 196620003880 substrate binding site [chemical binding]; other site 196620003881 ligand binding site [chemical binding]; other site 196620003882 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 196620003883 substrate binding site [chemical binding]; other site 196620003884 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 196620003885 active site 196620003886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 196620003887 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 196620003888 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 196620003889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620003890 ATP binding site [chemical binding]; other site 196620003891 Mg2+ binding site [ion binding]; other site 196620003892 G-X-G motif; other site 196620003893 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 196620003894 anchoring element; other site 196620003895 dimer interface [polypeptide binding]; other site 196620003896 ATP binding site [chemical binding]; other site 196620003897 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 196620003898 active site 196620003899 putative metal-binding site [ion binding]; other site 196620003900 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 196620003901 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 196620003902 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 196620003903 CAP-like domain; other site 196620003904 active site 196620003905 primary dimer interface [polypeptide binding]; other site 196620003906 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196620003907 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 196620003908 amino acid carrier protein; Region: agcS; TIGR00835 196620003909 CAT RNA binding domain; Region: CAT_RBD; smart01061 196620003910 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 196620003911 PRD domain; Region: PRD; pfam00874 196620003912 PRD domain; Region: PRD; pfam00874 196620003913 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 196620003914 Domain of unknown function DUF20; Region: UPF0118; pfam01594 196620003915 Predicted integral membrane protein [Function unknown]; Region: COG0392 196620003916 Uncharacterized conserved protein [Function unknown]; Region: COG2898 196620003917 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 196620003918 methionine sulfoxide reductase A; Provisional; Region: PRK14054 196620003919 Transcriptional regulator [Transcription]; Region: LytR; COG1316 196620003920 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 196620003921 active site 1 [active] 196620003922 dimer interface [polypeptide binding]; other site 196620003923 hexamer interface [polypeptide binding]; other site 196620003924 active site 2 [active] 196620003925 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 196620003926 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 196620003927 active site 196620003928 DNA binding site [nucleotide binding] 196620003929 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 196620003930 prephenate dehydrogenase; Validated; Region: PRK06545 196620003931 prephenate dehydrogenase; Validated; Region: PRK08507 196620003932 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 196620003933 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 196620003934 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 196620003935 putative oligomer interface [polypeptide binding]; other site 196620003936 putative active site [active] 196620003937 metal binding site [ion binding]; metal-binding site 196620003938 anthranilate synthase component I; Provisional; Region: PRK13567 196620003939 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 196620003940 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 196620003941 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 196620003942 Glutamine amidotransferase class-I; Region: GATase; pfam00117 196620003943 glutamine binding [chemical binding]; other site 196620003944 catalytic triad [active] 196620003945 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 196620003946 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 196620003947 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 196620003948 active site 196620003949 ribulose/triose binding site [chemical binding]; other site 196620003950 phosphate binding site [ion binding]; other site 196620003951 substrate (anthranilate) binding pocket [chemical binding]; other site 196620003952 product (indole) binding pocket [chemical binding]; other site 196620003953 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 196620003954 active site 196620003955 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 196620003956 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 196620003957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620003958 catalytic residue [active] 196620003959 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 196620003960 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 196620003961 substrate binding site [chemical binding]; other site 196620003962 active site 196620003963 catalytic residues [active] 196620003964 heterodimer interface [polypeptide binding]; other site 196620003965 FemAB family; Region: FemAB; pfam02388 196620003966 FlxA-like protein; Region: FlxA; pfam14282 196620003967 FemAB family; Region: FemAB; pfam02388 196620003968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 196620003969 active site 196620003970 motif I; other site 196620003971 motif II; other site 196620003972 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 196620003973 SWIM zinc finger; Region: SWIM; pfam04434 196620003974 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 196620003975 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196620003976 Walker A/P-loop; other site 196620003977 ATP binding site [chemical binding]; other site 196620003978 Q-loop/lid; other site 196620003979 ABC transporter signature motif; other site 196620003980 Walker B; other site 196620003981 D-loop; other site 196620003982 H-loop/switch region; other site 196620003983 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196620003984 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 196620003985 Walker A/P-loop; other site 196620003986 ATP binding site [chemical binding]; other site 196620003987 Q-loop/lid; other site 196620003988 ABC transporter signature motif; other site 196620003989 Walker B; other site 196620003990 D-loop; other site 196620003991 H-loop/switch region; other site 196620003992 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 196620003993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620003994 dimer interface [polypeptide binding]; other site 196620003995 conserved gate region; other site 196620003996 putative PBP binding loops; other site 196620003997 ABC-ATPase subunit interface; other site 196620003998 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 196620003999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620004000 dimer interface [polypeptide binding]; other site 196620004001 conserved gate region; other site 196620004002 putative PBP binding loops; other site 196620004003 ABC-ATPase subunit interface; other site 196620004004 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 196620004005 oligoendopeptidase F; Region: pepF; TIGR00181 196620004006 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 196620004007 active site 196620004008 Zn binding site [ion binding]; other site 196620004009 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 196620004010 PhoU domain; Region: PhoU; pfam01895 196620004011 PhoU domain; Region: PhoU; pfam01895 196620004012 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 196620004013 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 196620004014 Walker A/P-loop; other site 196620004015 ATP binding site [chemical binding]; other site 196620004016 Q-loop/lid; other site 196620004017 ABC transporter signature motif; other site 196620004018 Walker B; other site 196620004019 D-loop; other site 196620004020 H-loop/switch region; other site 196620004021 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 196620004022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620004023 dimer interface [polypeptide binding]; other site 196620004024 conserved gate region; other site 196620004025 putative PBP binding loops; other site 196620004026 ABC-ATPase subunit interface; other site 196620004027 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 196620004028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620004029 dimer interface [polypeptide binding]; other site 196620004030 conserved gate region; other site 196620004031 ABC-ATPase subunit interface; other site 196620004032 phosphate binding protein; Region: ptsS_2; TIGR02136 196620004033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 196620004034 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 196620004035 S1 domain; Region: S1_2; pfam13509 196620004036 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 196620004037 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196620004038 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196620004039 ABC transporter; Region: ABC_tran_2; pfam12848 196620004040 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196620004041 aspartate kinase; Reviewed; Region: PRK06635 196620004042 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 196620004043 putative nucleotide binding site [chemical binding]; other site 196620004044 putative catalytic residues [active] 196620004045 putative Mg ion binding site [ion binding]; other site 196620004046 putative aspartate binding site [chemical binding]; other site 196620004047 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 196620004048 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 196620004049 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 196620004050 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 196620004051 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 196620004052 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 196620004053 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 196620004054 dimer interface [polypeptide binding]; other site 196620004055 active site 196620004056 catalytic residue [active] 196620004057 dihydrodipicolinate reductase; Provisional; Region: PRK00048 196620004058 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 196620004059 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 196620004060 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 196620004061 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 196620004062 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 196620004063 active site 196620004064 trimer interface [polypeptide binding]; other site 196620004065 substrate binding site [chemical binding]; other site 196620004066 CoA binding site [chemical binding]; other site 196620004067 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 196620004068 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 196620004069 metal binding site [ion binding]; metal-binding site 196620004070 dimer interface [polypeptide binding]; other site 196620004071 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 196620004072 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 196620004073 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196620004074 catalytic residue [active] 196620004075 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 196620004076 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 196620004077 active site 196620004078 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196620004079 substrate binding site [chemical binding]; other site 196620004080 catalytic residues [active] 196620004081 dimer interface [polypeptide binding]; other site 196620004082 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 196620004083 DNA-binding site [nucleotide binding]; DNA binding site 196620004084 RNA-binding motif; other site 196620004085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 196620004086 acylphosphatase; Provisional; Region: PRK14431 196620004087 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 196620004088 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 196620004089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 196620004090 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 196620004091 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 196620004092 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 196620004093 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 196620004094 metal ion-dependent adhesion site (MIDAS); other site 196620004095 MoxR-like ATPases [General function prediction only]; Region: COG0714 196620004096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620004097 Walker A motif; other site 196620004098 ATP binding site [chemical binding]; other site 196620004099 Walker B motif; other site 196620004100 arginine finger; other site 196620004101 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 196620004102 active site 196620004103 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 196620004104 active site 196620004105 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 196620004106 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 196620004107 E3 interaction surface; other site 196620004108 lipoyl attachment site [posttranslational modification]; other site 196620004109 e3 binding domain; Region: E3_binding; pfam02817 196620004110 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 196620004111 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 196620004112 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 196620004113 TPP-binding site [chemical binding]; other site 196620004114 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 196620004115 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 196620004116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 196620004117 HAMP domain; Region: HAMP; pfam00672 196620004118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196620004119 dimer interface [polypeptide binding]; other site 196620004120 phosphorylation site [posttranslational modification] 196620004121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620004122 ATP binding site [chemical binding]; other site 196620004123 Mg2+ binding site [ion binding]; other site 196620004124 G-X-G motif; other site 196620004125 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196620004126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620004127 active site 196620004128 phosphorylation site [posttranslational modification] 196620004129 intermolecular recognition site; other site 196620004130 dimerization interface [polypeptide binding]; other site 196620004131 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196620004132 DNA binding site [nucleotide binding] 196620004133 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 196620004134 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 196620004135 active site 196620004136 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 196620004137 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 196620004138 active site 196620004139 homodimer interface [polypeptide binding]; other site 196620004140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620004141 Coenzyme A binding pocket [chemical binding]; other site 196620004142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 196620004143 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 196620004144 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 196620004145 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 196620004146 protein binding site [polypeptide binding]; other site 196620004147 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 196620004148 Catalytic dyad [active] 196620004149 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 196620004150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 196620004151 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 196620004152 HPr interaction site; other site 196620004153 glycerol kinase (GK) interaction site [polypeptide binding]; other site 196620004154 active site 196620004155 phosphorylation site [posttranslational modification] 196620004156 methionine sulfoxide reductase B; Provisional; Region: PRK00222 196620004157 SelR domain; Region: SelR; pfam01641 196620004158 methionine sulfoxide reductase A; Provisional; Region: PRK13014 196620004159 EDD domain protein, DegV family; Region: DegV; TIGR00762 196620004160 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 196620004161 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 196620004162 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 196620004163 folate binding site [chemical binding]; other site 196620004164 NADP+ binding site [chemical binding]; other site 196620004165 thymidylate synthase; Region: thym_sym; TIGR03284 196620004166 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 196620004167 dimerization interface [polypeptide binding]; other site 196620004168 active site 196620004169 Disulphide isomerase; Region: Disulph_isomer; pfam06491 196620004170 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 196620004171 Virulence factor; Region: Virulence_fact; pfam13769 196620004172 HEAT repeats; Region: HEAT_2; pfam13646 196620004173 HEAT repeat; Region: HEAT; pfam02985 196620004174 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 196620004175 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 196620004176 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 196620004177 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 196620004178 RNA/DNA hybrid binding site [nucleotide binding]; other site 196620004179 active site 196620004180 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 196620004181 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 196620004182 GA module; Region: GA; smart00844 196620004183 GA module; Region: GA; smart00844 196620004184 GA module; Region: GA; smart00844 196620004185 GA module; Region: GA; smart00844 196620004186 GA module; Region: GA; smart00844 196620004187 GA module; Region: GA; smart00844 196620004188 GA module; Region: GA; smart00844 196620004189 GA module; Region: GA; smart00844 196620004190 GA module; Region: GA; smart00844 196620004191 GA module; Region: GA; smart00844 196620004192 GA module; Region: GA; smart00844 196620004193 GA module; Region: GA; smart00844 196620004194 GA module; Region: GA; smart00844 196620004195 GA module; Region: GA; smart00844 196620004196 Predicted membrane protein [Function unknown]; Region: COG1511 196620004197 GA module; Region: GA; smart00844 196620004198 GA module; Region: GA; smart00844 196620004199 GA module; Region: GA; smart00844 196620004200 GA module; Region: GA; smart00844 196620004201 GA module; Region: GA; smart00844 196620004202 GA module; Region: GA; smart00844 196620004203 GA module; Region: GA; smart00844 196620004204 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 196620004205 GA module; Region: GA; smart00844 196620004206 GA module; Region: GA; smart00844 196620004207 GA module; Region: GA; smart00844 196620004208 GA module; Region: GA; smart00844 196620004209 GA module; Region: GA; smart00844 196620004210 GA module; Region: GA; smart00844 196620004211 GA module; Region: GA; smart00844 196620004212 GA module; Region: GA; pfam01468 196620004213 GA module; Region: GA; smart00844 196620004214 GA module; Region: GA; smart00844 196620004215 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 196620004216 GA module; Region: GA; smart00844 196620004217 GA module; Region: GA; smart00844 196620004218 GA module; Region: GA; smart00844 196620004219 GA module; Region: GA; smart00844 196620004220 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 196620004221 GA module; Region: GA; smart00844 196620004222 GA module; Region: GA; smart00844 196620004223 GA module; Region: GA; pfam01468 196620004224 GA module; Region: GA; smart00844 196620004225 GA module; Region: GA; smart00844 196620004226 GA module; Region: GA; smart00844 196620004227 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620004228 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620004229 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620004230 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 196620004231 Amino acid permease; Region: AA_permease_2; pfam13520 196620004232 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 196620004233 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 196620004234 tetramer interface [polypeptide binding]; other site 196620004235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620004236 catalytic residue [active] 196620004237 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 196620004238 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 196620004239 hexamer interface [polypeptide binding]; other site 196620004240 ligand binding site [chemical binding]; other site 196620004241 putative active site [active] 196620004242 NAD(P) binding site [chemical binding]; other site 196620004243 5'-3' exonuclease; Region: 53EXOc; smart00475 196620004244 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 196620004245 active site 196620004246 metal binding site 1 [ion binding]; metal-binding site 196620004247 putative 5' ssDNA interaction site; other site 196620004248 metal binding site 3; metal-binding site 196620004249 metal binding site 2 [ion binding]; metal-binding site 196620004250 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 196620004251 putative DNA binding site [nucleotide binding]; other site 196620004252 putative metal binding site [ion binding]; other site 196620004253 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 196620004254 Dynamin family; Region: Dynamin_N; pfam00350 196620004255 G1 box; other site 196620004256 GTP/Mg2+ binding site [chemical binding]; other site 196620004257 G2 box; other site 196620004258 Switch I region; other site 196620004259 G3 box; other site 196620004260 Switch II region; other site 196620004261 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 196620004262 G4 box; other site 196620004263 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 196620004264 Dynamin family; Region: Dynamin_N; pfam00350 196620004265 G1 box; other site 196620004266 GTP/Mg2+ binding site [chemical binding]; other site 196620004267 G2 box; other site 196620004268 Switch I region; other site 196620004269 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 196620004270 G3 box; other site 196620004271 Switch II region; other site 196620004272 GTP/Mg2+ binding site [chemical binding]; other site 196620004273 G4 box; other site 196620004274 G5 box; other site 196620004275 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 196620004276 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 196620004277 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 196620004278 Cobalt transport protein component CbiN; Region: CbiN; cl00842 196620004279 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 196620004280 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 196620004281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 196620004282 cell division protein GpsB; Provisional; Region: PRK14127 196620004283 DivIVA domain; Region: DivI1A_domain; TIGR03544 196620004284 hypothetical protein; Provisional; Region: PRK13660 196620004285 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 196620004286 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 196620004287 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 196620004288 Transglycosylase; Region: Transgly; pfam00912 196620004289 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 196620004290 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 196620004291 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 196620004292 minor groove reading motif; other site 196620004293 helix-hairpin-helix signature motif; other site 196620004294 substrate binding pocket [chemical binding]; other site 196620004295 active site 196620004296 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 196620004297 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 196620004298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 196620004299 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 196620004300 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 196620004301 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 196620004302 putative dimer interface [polypeptide binding]; other site 196620004303 putative anticodon binding site; other site 196620004304 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 196620004305 homodimer interface [polypeptide binding]; other site 196620004306 motif 1; other site 196620004307 motif 2; other site 196620004308 active site 196620004309 motif 3; other site 196620004310 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 196620004311 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 196620004312 active site 196620004313 catalytic site [active] 196620004314 substrate binding site [chemical binding]; other site 196620004315 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 196620004316 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 196620004317 Biotin operon repressor [Transcription]; Region: BirA; COG1654 196620004318 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 196620004319 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 196620004320 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 196620004321 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 196620004322 active site 196620004323 NTP binding site [chemical binding]; other site 196620004324 metal binding triad [ion binding]; metal-binding site 196620004325 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 196620004326 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 196620004327 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 196620004328 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 196620004329 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 196620004330 homodimer interface [polypeptide binding]; other site 196620004331 metal binding site [ion binding]; metal-binding site 196620004332 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 196620004333 Predicted membrane protein [Function unknown]; Region: COG4347 196620004334 Uncharacterized conserved protein [Function unknown]; Region: COG5582 196620004335 UPF0302 domain; Region: UPF0302; pfam08864 196620004336 A short protein domain of unknown function; Region: IDEAL; smart00914 196620004337 TPR repeat; Region: TPR_11; pfam13414 196620004338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 196620004339 binding surface 196620004340 TPR motif; other site 196620004341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 196620004342 TPR motif; other site 196620004343 binding surface 196620004344 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 196620004345 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 196620004346 hinge; other site 196620004347 active site 196620004348 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 196620004349 active site 196620004350 NAD binding site [chemical binding]; other site 196620004351 metal binding site [ion binding]; metal-binding site 196620004352 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 196620004353 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 196620004354 Tetramer interface [polypeptide binding]; other site 196620004355 active site 196620004356 FMN-binding site [chemical binding]; other site 196620004357 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 196620004358 active site 196620004359 multimer interface [polypeptide binding]; other site 196620004360 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 196620004361 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 196620004362 substrate binding pocket [chemical binding]; other site 196620004363 chain length determination region; other site 196620004364 substrate-Mg2+ binding site; other site 196620004365 catalytic residues [active] 196620004366 aspartate-rich region 1; other site 196620004367 active site lid residues [active] 196620004368 aspartate-rich region 2; other site 196620004369 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 196620004370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620004371 S-adenosylmethionine binding site [chemical binding]; other site 196620004372 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 196620004373 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 196620004374 IHF dimer interface [polypeptide binding]; other site 196620004375 IHF - DNA interface [nucleotide binding]; other site 196620004376 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 196620004377 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 196620004378 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 196620004379 GTP-binding protein Der; Reviewed; Region: PRK00093 196620004380 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 196620004381 G1 box; other site 196620004382 GTP/Mg2+ binding site [chemical binding]; other site 196620004383 Switch I region; other site 196620004384 G2 box; other site 196620004385 Switch II region; other site 196620004386 G3 box; other site 196620004387 G4 box; other site 196620004388 G5 box; other site 196620004389 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 196620004390 G1 box; other site 196620004391 GTP/Mg2+ binding site [chemical binding]; other site 196620004392 Switch I region; other site 196620004393 G2 box; other site 196620004394 G3 box; other site 196620004395 Switch II region; other site 196620004396 G4 box; other site 196620004397 G5 box; other site 196620004398 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 196620004399 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 196620004400 RNA binding site [nucleotide binding]; other site 196620004401 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 196620004402 RNA binding site [nucleotide binding]; other site 196620004403 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 196620004404 RNA binding site [nucleotide binding]; other site 196620004405 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 196620004406 RNA binding site [nucleotide binding]; other site 196620004407 cytidylate kinase; Provisional; Region: cmk; PRK00023 196620004408 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 196620004409 CMP-binding site; other site 196620004410 The sites determining sugar specificity; other site 196620004411 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 196620004412 active site 196620004413 homotetramer interface [polypeptide binding]; other site 196620004414 homodimer interface [polypeptide binding]; other site 196620004415 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 196620004416 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 196620004417 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196620004418 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 196620004419 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 196620004420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196620004421 ATP binding site [chemical binding]; other site 196620004422 putative Mg++ binding site [ion binding]; other site 196620004423 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196620004424 nucleotide binding region [chemical binding]; other site 196620004425 ATP-binding site [chemical binding]; other site 196620004426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 196620004427 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 196620004428 Predicted membrane protein [Function unknown]; Region: COG3601 196620004429 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 196620004430 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 196620004431 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 196620004432 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 196620004433 beta-channel forming cytolysin; Region: hlyII; TIGR01002 196620004434 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 196620004435 CHAP domain; Region: CHAP; pfam05257 196620004436 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 196620004437 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 196620004438 active site 196620004439 metal binding site [ion binding]; metal-binding site 196620004440 Bacterial SH3 domain homologues; Region: SH3b; smart00287 196620004441 holin, SPP1 family; Region: holin_SPP1; TIGR01592 196620004442 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 196620004443 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 196620004444 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 196620004445 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 196620004446 hypothetical protein; Provisional; Region: PRK05926 196620004447 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 196620004448 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 196620004449 Phage tail protein; Region: Sipho_tail; pfam05709 196620004450 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 196620004451 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 196620004452 linker region; other site 196620004453 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 196620004454 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 196620004455 Peptidase family M23; Region: Peptidase_M23; pfam01551 196620004456 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 196620004457 N-acetyl-D-glucosamine binding site [chemical binding]; other site 196620004458 catalytic residue [active] 196620004459 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 196620004460 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 196620004461 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 196620004462 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 196620004463 oligomerization interface [polypeptide binding]; other site 196620004464 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 196620004465 Phage capsid family; Region: Phage_capsid; pfam05065 196620004466 Clp protease; Region: CLP_protease; pfam00574 196620004467 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 196620004468 oligomer interface [polypeptide binding]; other site 196620004469 active site residues [active] 196620004470 Phage-related protein [Function unknown]; Region: COG4695; cl01923 196620004471 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 196620004472 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 196620004473 Phage terminase, small subunit; Region: Terminase_4; pfam05119 196620004474 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 196620004475 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196620004476 active site 196620004477 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 196620004478 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 196620004479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196620004480 ATP binding site [chemical binding]; other site 196620004481 putative Mg++ binding site [ion binding]; other site 196620004482 helicase superfamily c-terminal domain; Region: HELICc; smart00490 196620004483 VRR-NUC domain; Region: VRR_NUC; pfam08774 196620004484 Virulence-associated protein E; Region: VirE; pfam05272 196620004485 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 196620004486 Transcriptional activator RinB; Region: RinB; pfam06116 196620004487 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 196620004488 dUTPase; Region: dUTPase_2; pfam08761 196620004489 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 196620004490 active site 196620004491 homodimer interface [polypeptide binding]; other site 196620004492 metal binding site [ion binding]; metal-binding site 196620004493 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 196620004494 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 196620004495 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 196620004496 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 196620004497 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 196620004498 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 196620004499 active site 196620004500 DNA binding site [nucleotide binding] 196620004501 catalytic site [active] 196620004502 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 196620004503 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 196620004504 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 196620004505 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 196620004506 Homeodomain-like domain; Region: HTH_23; pfam13384 196620004507 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 196620004508 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196620004509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196620004510 non-specific DNA binding site [nucleotide binding]; other site 196620004511 salt bridge; other site 196620004512 sequence-specific DNA binding site [nucleotide binding]; other site 196620004513 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196620004514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196620004515 non-specific DNA binding site [nucleotide binding]; other site 196620004516 salt bridge; other site 196620004517 sequence-specific DNA binding site [nucleotide binding]; other site 196620004518 Domain of unknown function (DUF955); Region: DUF955; cl01076 196620004519 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 196620004520 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 196620004521 Int/Topo IB signature motif; other site 196620004522 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 196620004523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196620004524 dimerization interface [polypeptide binding]; other site 196620004525 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 196620004526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196620004527 dimer interface [polypeptide binding]; other site 196620004528 phosphorylation site [posttranslational modification] 196620004529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620004530 ATP binding site [chemical binding]; other site 196620004531 Mg2+ binding site [ion binding]; other site 196620004532 G-X-G motif; other site 196620004533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196620004534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620004535 active site 196620004536 phosphorylation site [posttranslational modification] 196620004537 intermolecular recognition site; other site 196620004538 dimerization interface [polypeptide binding]; other site 196620004539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196620004540 DNA binding site [nucleotide binding] 196620004541 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 196620004542 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196620004543 RNA binding surface [nucleotide binding]; other site 196620004544 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 196620004545 active site 196620004546 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 196620004547 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 196620004548 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 196620004549 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 196620004550 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 196620004551 active site 196620004552 Int/Topo IB signature motif; other site 196620004553 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 196620004554 metal binding site 2 [ion binding]; metal-binding site 196620004555 putative DNA binding helix; other site 196620004556 metal binding site 1 [ion binding]; metal-binding site 196620004557 dimer interface [polypeptide binding]; other site 196620004558 structural Zn2+ binding site [ion binding]; other site 196620004559 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 196620004560 dimer interface [polypeptide binding]; other site 196620004561 ADP-ribose binding site [chemical binding]; other site 196620004562 active site 196620004563 nudix motif; other site 196620004564 metal binding site [ion binding]; metal-binding site 196620004565 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196620004566 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 196620004567 active site 196620004568 catalytic tetrad [active] 196620004569 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 196620004570 classical (c) SDRs; Region: SDR_c; cd05233 196620004571 NAD(P) binding site [chemical binding]; other site 196620004572 active site 196620004573 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 196620004574 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 196620004575 ribonuclease Z; Region: RNase_Z; TIGR02651 196620004576 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 196620004577 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 196620004578 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 196620004579 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 196620004580 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 196620004581 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 196620004582 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 196620004583 Ca binding site [ion binding]; other site 196620004584 active site 196620004585 catalytic site [active] 196620004586 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196620004587 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196620004588 DNA binding site [nucleotide binding] 196620004589 domain linker motif; other site 196620004590 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 196620004591 putative ligand binding site [chemical binding]; other site 196620004592 putative dimerization interface [polypeptide binding]; other site 196620004593 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 196620004594 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 196620004595 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 196620004596 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 196620004597 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 196620004598 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 196620004599 peptidase T-like protein; Region: PepT-like; TIGR01883 196620004600 metal binding site [ion binding]; metal-binding site 196620004601 putative dimer interface [polypeptide binding]; other site 196620004602 Predicted membrane protein [Function unknown]; Region: COG4129 196620004603 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 196620004604 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 196620004605 Disulphide isomerase; Region: Disulph_isomer; pfam06491 196620004606 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 196620004607 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 196620004608 E3 interaction surface; other site 196620004609 lipoyl attachment site [posttranslational modification]; other site 196620004610 e3 binding domain; Region: E3_binding; pfam02817 196620004611 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 196620004612 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 196620004613 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 196620004614 alpha subunit interface [polypeptide binding]; other site 196620004615 TPP binding site [chemical binding]; other site 196620004616 heterodimer interface [polypeptide binding]; other site 196620004617 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 196620004618 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 196620004619 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 196620004620 tetramer interface [polypeptide binding]; other site 196620004621 TPP-binding site [chemical binding]; other site 196620004622 heterodimer interface [polypeptide binding]; other site 196620004623 phosphorylation loop region [posttranslational modification] 196620004624 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 196620004625 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 196620004626 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196620004627 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 196620004628 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 196620004629 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 196620004630 Walker A/P-loop; other site 196620004631 ATP binding site [chemical binding]; other site 196620004632 Q-loop/lid; other site 196620004633 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 196620004634 ABC transporter signature motif; other site 196620004635 Walker B; other site 196620004636 D-loop; other site 196620004637 H-loop/switch region; other site 196620004638 arginine repressor; Provisional; Region: PRK04280 196620004639 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 196620004640 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 196620004641 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 196620004642 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 196620004643 substrate binding pocket [chemical binding]; other site 196620004644 chain length determination region; other site 196620004645 substrate-Mg2+ binding site; other site 196620004646 catalytic residues [active] 196620004647 aspartate-rich region 1; other site 196620004648 active site lid residues [active] 196620004649 aspartate-rich region 2; other site 196620004650 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 196620004651 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 196620004652 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 196620004653 generic binding surface II; other site 196620004654 generic binding surface I; other site 196620004655 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 196620004656 putative RNA binding site [nucleotide binding]; other site 196620004657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 196620004658 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 196620004659 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 196620004660 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 196620004661 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 196620004662 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 196620004663 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 196620004664 carboxyltransferase (CT) interaction site; other site 196620004665 biotinylation site [posttranslational modification]; other site 196620004666 elongation factor P; Validated; Region: PRK00529 196620004667 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 196620004668 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 196620004669 RNA binding site [nucleotide binding]; other site 196620004670 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 196620004671 RNA binding site [nucleotide binding]; other site 196620004672 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 196620004673 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 196620004674 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 196620004675 active site 196620004676 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 196620004677 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 196620004678 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196620004679 active site residue [active] 196620004680 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 196620004681 tetramer interface [polypeptide binding]; other site 196620004682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620004683 catalytic residue [active] 196620004684 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 196620004685 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 196620004686 tetramer interface [polypeptide binding]; other site 196620004687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620004688 catalytic residue [active] 196620004689 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 196620004690 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 196620004691 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 196620004692 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 196620004693 ADP binding site [chemical binding]; other site 196620004694 magnesium binding site [ion binding]; other site 196620004695 putative shikimate binding site; other site 196620004696 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 196620004697 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 196620004698 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 196620004699 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 196620004700 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 196620004701 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 196620004702 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 196620004703 Type II/IV secretion system protein; Region: T2SE; pfam00437 196620004704 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 196620004705 Walker A motif; other site 196620004706 ATP binding site [chemical binding]; other site 196620004707 Walker B motif; other site 196620004708 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 196620004709 Uncharacterized conserved protein [Function unknown]; Region: COG0011 196620004710 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 196620004711 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 196620004712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 196620004713 Rhomboid family; Region: Rhomboid; pfam01694 196620004714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 196620004715 binding surface 196620004716 TPR motif; other site 196620004717 Tetratricopeptide repeat; Region: TPR_16; pfam13432 196620004718 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 196620004719 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 196620004720 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 196620004721 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 196620004722 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 196620004723 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 196620004724 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 196620004725 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 196620004726 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 196620004727 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 196620004728 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 196620004729 metal binding site 2 [ion binding]; metal-binding site 196620004730 putative DNA binding helix; other site 196620004731 metal binding site 1 [ion binding]; metal-binding site 196620004732 dimer interface [polypeptide binding]; other site 196620004733 structural Zn2+ binding site [ion binding]; other site 196620004734 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 196620004735 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196620004736 ABC-ATPase subunit interface; other site 196620004737 dimer interface [polypeptide binding]; other site 196620004738 putative PBP binding regions; other site 196620004739 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 196620004740 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 196620004741 endonuclease IV; Provisional; Region: PRK01060 196620004742 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 196620004743 AP (apurinic/apyrimidinic) site pocket; other site 196620004744 DNA interaction; other site 196620004745 Metal-binding active site; metal-binding site 196620004746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 196620004747 DEAD-like helicases superfamily; Region: DEXDc; smart00487 196620004748 ATP binding site [chemical binding]; other site 196620004749 putative Mg++ binding site [ion binding]; other site 196620004750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196620004751 nucleotide binding region [chemical binding]; other site 196620004752 ATP-binding site [chemical binding]; other site 196620004753 Uncharacterized conserved protein [Function unknown]; Region: COG0327 196620004754 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 196620004755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 196620004756 Uncharacterized conserved protein [Function unknown]; Region: COG0327 196620004757 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 196620004758 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 196620004759 Family of unknown function (DUF633); Region: DUF633; pfam04816 196620004760 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 196620004761 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 196620004762 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 196620004763 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196620004764 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 196620004765 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196620004766 DNA binding residues [nucleotide binding] 196620004767 DNA primase, catalytic core; Region: dnaG; TIGR01391 196620004768 CHC2 zinc finger; Region: zf-CHC2; pfam01807 196620004769 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 196620004770 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 196620004771 active site 196620004772 metal binding site [ion binding]; metal-binding site 196620004773 interdomain interaction site; other site 196620004774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 196620004775 HTH domain; Region: HTH_11; cl17392 196620004776 FOG: CBS domain [General function prediction only]; Region: COG0517 196620004777 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 196620004778 glycyl-tRNA synthetase; Provisional; Region: PRK04173 196620004779 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 196620004780 motif 1; other site 196620004781 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 196620004782 active site 196620004783 motif 2; other site 196620004784 motif 3; other site 196620004785 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 196620004786 anticodon binding site; other site 196620004787 DNA repair protein RecO; Region: reco; TIGR00613 196620004788 Recombination protein O N terminal; Region: RecO_N; pfam11967 196620004789 Recombination protein O C terminal; Region: RecO_C; pfam02565 196620004790 GTPase Era; Reviewed; Region: era; PRK00089 196620004791 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 196620004792 G1 box; other site 196620004793 GTP/Mg2+ binding site [chemical binding]; other site 196620004794 Switch I region; other site 196620004795 G2 box; other site 196620004796 Switch II region; other site 196620004797 G3 box; other site 196620004798 G4 box; other site 196620004799 G5 box; other site 196620004800 KH domain; Region: KH_2; pfam07650 196620004801 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 196620004802 active site 196620004803 catalytic motif [active] 196620004804 Zn binding site [ion binding]; other site 196620004805 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 196620004806 metal-binding heat shock protein; Provisional; Region: PRK00016 196620004807 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 196620004808 PhoH-like protein; Region: PhoH; pfam02562 196620004809 hypothetical protein; Provisional; Region: PRK13665 196620004810 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 196620004811 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 196620004812 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 196620004813 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 196620004814 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196620004815 FeS/SAM binding site; other site 196620004816 TRAM domain; Region: TRAM; cl01282 196620004817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 196620004818 RNA methyltransferase, RsmE family; Region: TIGR00046 196620004819 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 196620004820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620004821 S-adenosylmethionine binding site [chemical binding]; other site 196620004822 chaperone protein DnaJ; Provisional; Region: PRK14280 196620004823 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 196620004824 HSP70 interaction site [polypeptide binding]; other site 196620004825 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 196620004826 substrate binding site [polypeptide binding]; other site 196620004827 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 196620004828 Zn binding sites [ion binding]; other site 196620004829 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 196620004830 dimer interface [polypeptide binding]; other site 196620004831 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 196620004832 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 196620004833 nucleotide binding site [chemical binding]; other site 196620004834 NEF interaction site [polypeptide binding]; other site 196620004835 SBD interface [polypeptide binding]; other site 196620004836 heat shock protein GrpE; Provisional; Region: PRK14140 196620004837 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 196620004838 dimer interface [polypeptide binding]; other site 196620004839 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 196620004840 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 196620004841 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 196620004842 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 196620004843 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 196620004844 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196620004845 FeS/SAM binding site; other site 196620004846 HemN C-terminal domain; Region: HemN_C; pfam06969 196620004847 GTP-binding protein LepA; Provisional; Region: PRK05433 196620004848 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 196620004849 G1 box; other site 196620004850 putative GEF interaction site [polypeptide binding]; other site 196620004851 GTP/Mg2+ binding site [chemical binding]; other site 196620004852 Switch I region; other site 196620004853 G2 box; other site 196620004854 G3 box; other site 196620004855 Switch II region; other site 196620004856 G4 box; other site 196620004857 G5 box; other site 196620004858 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 196620004859 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 196620004860 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 196620004861 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 196620004862 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 196620004863 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 196620004864 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 196620004865 Competence protein; Region: Competence; pfam03772 196620004866 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 196620004867 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 196620004868 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 196620004869 catalytic motif [active] 196620004870 Zn binding site [ion binding]; other site 196620004871 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 196620004872 SLBB domain; Region: SLBB; pfam10531 196620004873 Helix-hairpin-helix motif; Region: HHH; pfam00633 196620004874 Methyltransferase domain; Region: Methyltransf_31; pfam13847 196620004875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620004876 S-adenosylmethionine binding site [chemical binding]; other site 196620004877 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 196620004878 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 196620004879 Zn2+ binding site [ion binding]; other site 196620004880 Mg2+ binding site [ion binding]; other site 196620004881 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 196620004882 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 196620004883 active site 196620004884 (T/H)XGH motif; other site 196620004885 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 196620004886 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 196620004887 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 196620004888 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 196620004889 shikimate binding site; other site 196620004890 NAD(P) binding site [chemical binding]; other site 196620004891 GTPase YqeH; Provisional; Region: PRK13796 196620004892 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 196620004893 GTP/Mg2+ binding site [chemical binding]; other site 196620004894 G4 box; other site 196620004895 G5 box; other site 196620004896 G1 box; other site 196620004897 Switch I region; other site 196620004898 G2 box; other site 196620004899 G3 box; other site 196620004900 Switch II region; other site 196620004901 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 196620004902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620004903 active site 196620004904 motif I; other site 196620004905 motif II; other site 196620004906 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 196620004907 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 196620004908 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 196620004909 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620004910 Fic family protein [Function unknown]; Region: COG3177 196620004911 Fic/DOC family; Region: Fic; pfam02661 196620004912 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 196620004913 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 196620004914 putative active site [active] 196620004915 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 196620004916 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 196620004917 ATP-grasp domain; Region: ATP-grasp_4; cl17255 196620004918 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 196620004919 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 196620004920 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 196620004921 carboxyltransferase (CT) interaction site; other site 196620004922 biotinylation site [posttranslational modification]; other site 196620004923 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 196620004924 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 196620004925 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 196620004926 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 196620004927 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 196620004928 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 196620004929 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 196620004930 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 196620004931 Sugar specificity; other site 196620004932 Pyrimidine base specificity; other site 196620004933 ATP-binding site [chemical binding]; other site 196620004934 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 196620004935 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 196620004936 Peptidase family U32; Region: Peptidase_U32; pfam01136 196620004937 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 196620004938 Peptidase family U32; Region: Peptidase_U32; pfam01136 196620004939 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 196620004940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620004941 S-adenosylmethionine binding site [chemical binding]; other site 196620004942 hypothetical protein; Provisional; Region: PRK13678 196620004943 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 196620004944 hypothetical protein; Provisional; Region: PRK05473 196620004945 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 196620004946 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 196620004947 motif 1; other site 196620004948 active site 196620004949 motif 2; other site 196620004950 motif 3; other site 196620004951 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 196620004952 DHHA1 domain; Region: DHHA1; pfam02272 196620004953 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 196620004954 AAA domain; Region: AAA_30; pfam13604 196620004955 Family description; Region: UvrD_C_2; pfam13538 196620004956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 196620004957 binding surface 196620004958 TPR motif; other site 196620004959 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 196620004960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 196620004961 binding surface 196620004962 TPR motif; other site 196620004963 TPR repeat; Region: TPR_11; pfam13414 196620004964 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 196620004965 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 196620004966 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 196620004967 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 196620004968 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196620004969 catalytic residue [active] 196620004970 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 196620004971 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 196620004972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 196620004973 Predicted transcriptional regulator [Transcription]; Region: COG1959 196620004974 Transcriptional regulator; Region: Rrf2; pfam02082 196620004975 recombination factor protein RarA; Reviewed; Region: PRK13342 196620004976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620004977 Walker A motif; other site 196620004978 ATP binding site [chemical binding]; other site 196620004979 Walker B motif; other site 196620004980 arginine finger; other site 196620004981 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 196620004982 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 196620004983 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 196620004984 putative ATP binding site [chemical binding]; other site 196620004985 putative substrate interface [chemical binding]; other site 196620004986 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 196620004987 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 196620004988 dimer interface [polypeptide binding]; other site 196620004989 anticodon binding site; other site 196620004990 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 196620004991 homodimer interface [polypeptide binding]; other site 196620004992 motif 1; other site 196620004993 active site 196620004994 motif 2; other site 196620004995 GAD domain; Region: GAD; pfam02938 196620004996 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 196620004997 motif 3; other site 196620004998 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 196620004999 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 196620005000 dimer interface [polypeptide binding]; other site 196620005001 motif 1; other site 196620005002 active site 196620005003 motif 2; other site 196620005004 motif 3; other site 196620005005 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 196620005006 anticodon binding site; other site 196620005007 Bacterial SH3 domain homologues; Region: SH3b; smart00287 196620005008 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 196620005009 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 196620005010 active site 196620005011 metal binding site [ion binding]; metal-binding site 196620005012 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 196620005013 putative active site [active] 196620005014 dimerization interface [polypeptide binding]; other site 196620005015 putative tRNAtyr binding site [nucleotide binding]; other site 196620005016 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 196620005017 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 196620005018 Zn2+ binding site [ion binding]; other site 196620005019 Mg2+ binding site [ion binding]; other site 196620005020 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 196620005021 synthetase active site [active] 196620005022 NTP binding site [chemical binding]; other site 196620005023 metal binding site [ion binding]; metal-binding site 196620005024 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 196620005025 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 196620005026 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196620005027 active site 196620005028 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 196620005029 DHH family; Region: DHH; pfam01368 196620005030 DHHA1 domain; Region: DHHA1; pfam02272 196620005031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 196620005032 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 196620005033 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 196620005034 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 196620005035 Protein export membrane protein; Region: SecD_SecF; pfam02355 196620005036 Preprotein translocase subunit; Region: YajC; pfam02699 196620005037 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 196620005038 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 196620005039 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 196620005040 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 196620005041 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 196620005042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620005043 Walker A motif; other site 196620005044 ATP binding site [chemical binding]; other site 196620005045 Walker B motif; other site 196620005046 arginine finger; other site 196620005047 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 196620005048 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 196620005049 RuvA N terminal domain; Region: RuvA_N; pfam01330 196620005050 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 196620005051 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 196620005052 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 196620005053 GTPase CgtA; Reviewed; Region: obgE; PRK12297 196620005054 GTP1/OBG; Region: GTP1_OBG; pfam01018 196620005055 Obg GTPase; Region: Obg; cd01898 196620005056 G1 box; other site 196620005057 GTP/Mg2+ binding site [chemical binding]; other site 196620005058 Switch I region; other site 196620005059 G2 box; other site 196620005060 G3 box; other site 196620005061 Switch II region; other site 196620005062 G4 box; other site 196620005063 G5 box; other site 196620005064 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 196620005065 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 196620005066 Protein of unknown function (DUF464); Region: DUF464; cl01080 196620005067 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 196620005068 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 196620005069 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 196620005070 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 196620005071 rod shape-determining protein MreC; Region: MreC; pfam04085 196620005072 hypothetical protein; Reviewed; Region: PRK00024 196620005073 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 196620005074 MPN+ (JAMM) motif; other site 196620005075 Zinc-binding site [ion binding]; other site 196620005076 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 196620005077 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 196620005078 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 196620005079 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 196620005080 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 196620005081 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 196620005082 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 196620005083 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196620005084 active site 196620005085 HIGH motif; other site 196620005086 nucleotide binding site [chemical binding]; other site 196620005087 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 196620005088 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 196620005089 active site 196620005090 KMSKS motif; other site 196620005091 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 196620005092 tRNA binding surface [nucleotide binding]; other site 196620005093 anticodon binding site; other site 196620005094 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 196620005095 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 196620005096 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 196620005097 Putative ammonia monooxygenase; Region: AmoA; pfam05145 196620005098 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 196620005099 similar to hypothetical protein 196620005100 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 196620005101 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196620005102 inhibitor-cofactor binding pocket; inhibition site 196620005103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620005104 catalytic residue [active] 196620005105 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 196620005106 dimer interface [polypeptide binding]; other site 196620005107 active site 196620005108 Schiff base residues; other site 196620005109 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 196620005110 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 196620005111 active site 196620005112 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 196620005113 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 196620005114 domain interfaces; other site 196620005115 active site 196620005116 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 196620005117 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 196620005118 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 196620005119 tRNA; other site 196620005120 putative tRNA binding site [nucleotide binding]; other site 196620005121 putative NADP binding site [chemical binding]; other site 196620005122 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 196620005123 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 196620005124 G1 box; other site 196620005125 GTP/Mg2+ binding site [chemical binding]; other site 196620005126 Switch I region; other site 196620005127 G2 box; other site 196620005128 G3 box; other site 196620005129 Switch II region; other site 196620005130 G4 box; other site 196620005131 G5 box; other site 196620005132 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 196620005133 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 196620005134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620005135 Walker A motif; other site 196620005136 ATP binding site [chemical binding]; other site 196620005137 Walker B motif; other site 196620005138 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 196620005139 trigger factor; Provisional; Region: tig; PRK01490 196620005140 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 196620005141 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 196620005142 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 196620005143 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 196620005144 23S rRNA binding site [nucleotide binding]; other site 196620005145 L21 binding site [polypeptide binding]; other site 196620005146 L13 binding site [polypeptide binding]; other site 196620005147 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 196620005148 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 196620005149 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 196620005150 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 196620005151 lysine transporter; Provisional; Region: PRK10836 196620005152 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 196620005153 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 196620005154 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 196620005155 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 196620005156 active site 196620005157 dimer interface [polypeptide binding]; other site 196620005158 motif 1; other site 196620005159 motif 2; other site 196620005160 motif 3; other site 196620005161 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 196620005162 anticodon binding site; other site 196620005163 primosomal protein DnaI; Reviewed; Region: PRK08939 196620005164 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 196620005165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620005166 Walker A motif; other site 196620005167 ATP binding site [chemical binding]; other site 196620005168 Walker B motif; other site 196620005169 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 196620005170 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 196620005171 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 196620005172 ATP cone domain; Region: ATP-cone; pfam03477 196620005173 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 196620005174 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 196620005175 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 196620005176 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 196620005177 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 196620005178 CoA-binding site [chemical binding]; other site 196620005179 ATP-binding [chemical binding]; other site 196620005180 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 196620005181 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 196620005182 DNA binding site [nucleotide binding] 196620005183 catalytic residue [active] 196620005184 H2TH interface [polypeptide binding]; other site 196620005185 putative catalytic residues [active] 196620005186 turnover-facilitating residue; other site 196620005187 intercalation triad [nucleotide binding]; other site 196620005188 8OG recognition residue [nucleotide binding]; other site 196620005189 putative reading head residues; other site 196620005190 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 196620005191 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 196620005192 DNA polymerase I; Provisional; Region: PRK05755 196620005193 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 196620005194 active site 196620005195 metal binding site 1 [ion binding]; metal-binding site 196620005196 putative 5' ssDNA interaction site; other site 196620005197 metal binding site 3; metal-binding site 196620005198 metal binding site 2 [ion binding]; metal-binding site 196620005199 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 196620005200 putative DNA binding site [nucleotide binding]; other site 196620005201 putative metal binding site [ion binding]; other site 196620005202 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 196620005203 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 196620005204 active site 196620005205 DNA binding site [nucleotide binding] 196620005206 catalytic site [active] 196620005207 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 196620005208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196620005209 dimer interface [polypeptide binding]; other site 196620005210 phosphorylation site [posttranslational modification] 196620005211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620005212 ATP binding site [chemical binding]; other site 196620005213 Mg2+ binding site [ion binding]; other site 196620005214 G-X-G motif; other site 196620005215 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196620005216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620005217 active site 196620005218 phosphorylation site [posttranslational modification] 196620005219 intermolecular recognition site; other site 196620005220 dimerization interface [polypeptide binding]; other site 196620005221 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196620005222 DNA binding site [nucleotide binding] 196620005223 isocitrate dehydrogenase; Reviewed; Region: PRK07006 196620005224 isocitrate dehydrogenase; Validated; Region: PRK07362 196620005225 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 196620005226 dimer interface [polypeptide binding]; other site 196620005227 Citrate synthase; Region: Citrate_synt; pfam00285 196620005228 active site 196620005229 citrylCoA binding site [chemical binding]; other site 196620005230 oxalacetate/citrate binding site [chemical binding]; other site 196620005231 coenzyme A binding site [chemical binding]; other site 196620005232 catalytic triad [active] 196620005233 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 196620005234 pyruvate kinase; Provisional; Region: PRK06354 196620005235 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 196620005236 domain interfaces; other site 196620005237 active site 196620005238 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 196620005239 6-phosphofructokinase; Provisional; Region: PRK03202 196620005240 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 196620005241 dimerization interface [polypeptide binding]; other site 196620005242 allosteric effector site; other site 196620005243 active site 196620005244 ADP/pyrophosphate binding site [chemical binding]; other site 196620005245 fructose-1,6-bisphosphate binding site; other site 196620005246 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 196620005247 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 196620005248 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 196620005249 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 196620005250 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 196620005251 Malic enzyme, N-terminal domain; Region: malic; pfam00390 196620005252 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 196620005253 putative NAD(P) binding site [chemical binding]; other site 196620005254 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 196620005255 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 196620005256 active site 196620005257 PHP Thumb interface [polypeptide binding]; other site 196620005258 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 196620005259 generic binding surface I; other site 196620005260 generic binding surface II; other site 196620005261 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 196620005262 DHH family; Region: DHH; pfam01368 196620005263 DHHA1 domain; Region: DHHA1; pfam02272 196620005264 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 196620005265 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 196620005266 DNA-binding site [nucleotide binding]; DNA binding site 196620005267 DRTGG domain; Region: DRTGG; pfam07085 196620005268 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 196620005269 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 196620005270 active site 2 [active] 196620005271 active site 1 [active] 196620005272 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196620005273 Ligand Binding Site [chemical binding]; other site 196620005274 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 196620005275 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 196620005276 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 196620005277 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 196620005278 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 196620005279 active site 196620005280 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 196620005281 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 196620005282 hexamer interface [polypeptide binding]; other site 196620005283 ligand binding site [chemical binding]; other site 196620005284 putative active site [active] 196620005285 NAD(P) binding site [chemical binding]; other site 196620005286 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196620005287 Ligand Binding Site [chemical binding]; other site 196620005288 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 196620005289 propionate/acetate kinase; Provisional; Region: PRK12379 196620005290 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 196620005291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620005292 S-adenosylmethionine binding site [chemical binding]; other site 196620005293 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 196620005294 dimer interface [polypeptide binding]; other site 196620005295 catalytic triad [active] 196620005296 peroxidatic and resolving cysteines [active] 196620005297 hypothetical protein; Provisional; Region: PRK10621 196620005298 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 196620005299 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 196620005300 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 196620005301 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 196620005302 Ligand Binding Site [chemical binding]; other site 196620005303 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 196620005304 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 196620005305 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196620005306 catalytic residue [active] 196620005307 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 196620005308 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 196620005309 GAF domain; Region: GAF_2; pfam13185 196620005310 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 196620005311 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 196620005312 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196620005313 RNA binding surface [nucleotide binding]; other site 196620005314 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 196620005315 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 196620005316 active site 196620005317 catalytic site [active] 196620005318 OsmC-like protein; Region: OsmC; cl00767 196620005319 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 196620005320 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196620005321 catalytic residue [active] 196620005322 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 196620005323 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 196620005324 ligand binding site [chemical binding]; other site 196620005325 NAD binding site [chemical binding]; other site 196620005326 dimerization interface [polypeptide binding]; other site 196620005327 catalytic site [active] 196620005328 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 196620005329 putative L-serine binding site [chemical binding]; other site 196620005330 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 196620005331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620005332 motif II; other site 196620005333 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 196620005334 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 196620005335 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 196620005336 active site turn [active] 196620005337 phosphorylation site [posttranslational modification] 196620005338 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 196620005339 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 196620005340 putative acyl-acceptor binding pocket; other site 196620005341 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 196620005342 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 196620005343 protein binding site [polypeptide binding]; other site 196620005344 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 196620005345 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 196620005346 active site 196620005347 HIGH motif; other site 196620005348 dimer interface [polypeptide binding]; other site 196620005349 KMSKS motif; other site 196620005350 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196620005351 RNA binding surface [nucleotide binding]; other site 196620005352 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 196620005353 Transglycosylase; Region: Transgly; pfam00912 196620005354 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 196620005355 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 196620005356 NEAr Transporter domain; Region: NEAT; smart00725 196620005357 NEAr Transporter domain; Region: NEAT; smart00725 196620005358 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 196620005359 heme-binding site [chemical binding]; other site 196620005360 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 196620005361 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 196620005362 Potassium binding sites [ion binding]; other site 196620005363 Cesium cation binding sites [ion binding]; other site 196620005364 acetyl-CoA synthetase; Provisional; Region: PRK04319 196620005365 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 196620005366 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 196620005367 active site 196620005368 acyl-activating enzyme (AAE) consensus motif; other site 196620005369 putative CoA binding site [chemical binding]; other site 196620005370 AMP binding site [chemical binding]; other site 196620005371 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 196620005372 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 196620005373 active site 196620005374 Zn binding site [ion binding]; other site 196620005375 catabolite control protein A; Region: ccpA; TIGR01481 196620005376 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196620005377 DNA binding site [nucleotide binding] 196620005378 domain linker motif; other site 196620005379 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 196620005380 dimerization interface [polypeptide binding]; other site 196620005381 effector binding site; other site 196620005382 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 196620005383 Chorismate mutase type II; Region: CM_2; cl00693 196620005384 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 196620005385 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 196620005386 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 196620005387 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 196620005388 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 196620005389 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 196620005390 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 196620005391 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 196620005392 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 196620005393 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 196620005394 putative tRNA-binding site [nucleotide binding]; other site 196620005395 hypothetical protein; Provisional; Region: PRK13668 196620005396 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 196620005397 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 196620005398 catalytic residues [active] 196620005399 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 196620005400 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 196620005401 oligomer interface [polypeptide binding]; other site 196620005402 active site 196620005403 metal binding site [ion binding]; metal-binding site 196620005404 Predicted small secreted protein [Function unknown]; Region: COG5584 196620005405 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 196620005406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620005407 S-adenosylmethionine binding site [chemical binding]; other site 196620005408 Phosphotransferase enzyme family; Region: APH; pfam01636 196620005409 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 196620005410 active site 196620005411 substrate binding site [chemical binding]; other site 196620005412 ATP binding site [chemical binding]; other site 196620005413 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 196620005414 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 196620005415 homodimer interface [polypeptide binding]; other site 196620005416 substrate-cofactor binding pocket; other site 196620005417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620005418 catalytic residue [active] 196620005419 dipeptidase PepV; Reviewed; Region: PRK07318 196620005420 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 196620005421 active site 196620005422 metal binding site [ion binding]; metal-binding site 196620005423 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 196620005424 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196620005425 RNA binding surface [nucleotide binding]; other site 196620005426 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 196620005427 active site 196620005428 uracil binding [chemical binding]; other site 196620005429 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 196620005430 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 196620005431 HI0933-like protein; Region: HI0933_like; pfam03486 196620005432 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 196620005433 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 196620005434 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620005435 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620005436 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620005437 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620005438 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620005439 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620005440 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620005441 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620005442 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620005443 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620005444 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620005445 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620005446 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620005447 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620005448 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196620005449 active site residue [active] 196620005450 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 196620005451 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 196620005452 HIGH motif; other site 196620005453 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 196620005454 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 196620005455 active site 196620005456 KMSKS motif; other site 196620005457 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 196620005458 tRNA binding surface [nucleotide binding]; other site 196620005459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620005460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196620005461 putative substrate translocation pore; other site 196620005462 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 196620005463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620005464 S-adenosylmethionine binding site [chemical binding]; other site 196620005465 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 196620005466 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 196620005467 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 196620005468 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 196620005469 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 196620005470 homopentamer interface [polypeptide binding]; other site 196620005471 active site 196620005472 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 196620005473 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 196620005474 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 196620005475 dimerization interface [polypeptide binding]; other site 196620005476 active site 196620005477 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 196620005478 Lumazine binding domain; Region: Lum_binding; pfam00677 196620005479 Lumazine binding domain; Region: Lum_binding; pfam00677 196620005480 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 196620005481 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 196620005482 catalytic motif [active] 196620005483 Zn binding site [ion binding]; other site 196620005484 RibD C-terminal domain; Region: RibD_C; cl17279 196620005485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 196620005486 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 196620005487 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196620005488 dimerization interface [polypeptide binding]; other site 196620005489 putative DNA binding site [nucleotide binding]; other site 196620005490 putative Zn2+ binding site [ion binding]; other site 196620005491 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 196620005492 arsenical pump membrane protein; Provisional; Region: PRK15445 196620005493 transmembrane helices; other site 196620005494 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 196620005495 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 196620005496 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 196620005497 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 196620005498 DNA binding residues [nucleotide binding] 196620005499 CAAX protease self-immunity; Region: Abi; pfam02517 196620005500 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 196620005501 active site 196620005502 intersubunit interactions; other site 196620005503 catalytic residue [active] 196620005504 camphor resistance protein CrcB; Provisional; Region: PRK14201 196620005505 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 196620005506 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 196620005507 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196620005508 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 196620005509 active site 196620005510 catalytic tetrad [active] 196620005511 S-adenosylmethionine synthetase; Validated; Region: PRK05250 196620005512 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 196620005513 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 196620005514 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 196620005515 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 196620005516 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 196620005517 active site 196620005518 substrate-binding site [chemical binding]; other site 196620005519 metal-binding site [ion binding] 196620005520 ATP binding site [chemical binding]; other site 196620005521 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 196620005522 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 196620005523 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 196620005524 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 196620005525 nudix motif; other site 196620005526 Haemolytic domain; Region: Haemolytic; pfam01809 196620005527 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 196620005528 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 196620005529 metal binding site [ion binding]; metal-binding site 196620005530 substrate binding pocket [chemical binding]; other site 196620005531 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 196620005532 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 196620005533 acyl-activating enzyme (AAE) consensus motif; other site 196620005534 putative AMP binding site [chemical binding]; other site 196620005535 putative active site [active] 196620005536 putative CoA binding site [chemical binding]; other site 196620005537 Excalibur calcium-binding domain; Region: Excalibur; smart00894 196620005538 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 196620005539 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 196620005540 Domain of unknown function (DUF955); Region: DUF955; pfam06114 196620005541 putative transposase OrfB; Reviewed; Region: PHA02517 196620005542 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 196620005543 Transposase; Region: HTH_Tnp_1; cl17663 196620005544 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 196620005545 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 196620005546 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 196620005547 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 196620005548 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 196620005549 HsdM N-terminal domain; Region: HsdM_N; pfam12161 196620005550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620005551 S-adenosylmethionine binding site [chemical binding]; other site 196620005552 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 196620005553 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 196620005554 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 196620005555 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 196620005556 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 196620005557 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 196620005558 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 196620005559 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 196620005560 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 196620005561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196620005562 Walker A/P-loop; other site 196620005563 ATP binding site [chemical binding]; other site 196620005564 Q-loop/lid; other site 196620005565 ABC transporter signature motif; other site 196620005566 Walker B; other site 196620005567 D-loop; other site 196620005568 H-loop/switch region; other site 196620005569 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 196620005570 active site 196620005571 catalytic triad [active] 196620005572 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 196620005573 Flavoprotein; Region: Flavoprotein; pfam02441 196620005574 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 196620005575 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 196620005576 active site 196620005577 zinc binding site [ion binding]; other site 196620005578 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 196620005579 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 196620005580 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 196620005581 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 196620005582 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 196620005583 beta-channel forming cytolysin; Region: hlyII; TIGR01002 196620005584 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 196620005585 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 196620005586 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 196620005587 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 196620005588 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 196620005589 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 196620005590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 196620005591 ferrochelatase; Provisional; Region: PRK12435 196620005592 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 196620005593 C-terminal domain interface [polypeptide binding]; other site 196620005594 active site 196620005595 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 196620005596 active site 196620005597 N-terminal domain interface [polypeptide binding]; other site 196620005598 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 196620005599 substrate binding site [chemical binding]; other site 196620005600 active site 196620005601 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 196620005602 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 196620005603 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 196620005604 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 196620005605 Walker A/P-loop; other site 196620005606 ATP binding site [chemical binding]; other site 196620005607 Q-loop/lid; other site 196620005608 ABC transporter signature motif; other site 196620005609 Walker B; other site 196620005610 D-loop; other site 196620005611 H-loop/switch region; other site 196620005612 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 196620005613 HIT family signature motif; other site 196620005614 catalytic residue [active] 196620005615 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 196620005616 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 196620005617 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 196620005618 SurA N-terminal domain; Region: SurA_N_3; cl07813 196620005619 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 196620005620 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 196620005621 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 196620005622 generic binding surface II; other site 196620005623 generic binding surface I; other site 196620005624 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 196620005625 Zn2+ binding site [ion binding]; other site 196620005626 Mg2+ binding site [ion binding]; other site 196620005627 Uncharacterized conserved protein [Function unknown]; Region: COG4717 196620005628 P-loop containing region of AAA domain; Region: AAA_29; cl17516 196620005629 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 196620005630 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 196620005631 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 196620005632 active site 196620005633 metal binding site [ion binding]; metal-binding site 196620005634 DNA binding site [nucleotide binding] 196620005635 hypothetical protein; Provisional; Region: PRK13676 196620005636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 196620005637 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196620005638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196620005639 non-specific DNA binding site [nucleotide binding]; other site 196620005640 salt bridge; other site 196620005641 sequence-specific DNA binding site [nucleotide binding]; other site 196620005642 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196620005643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620005644 active site 196620005645 phosphorylation site [posttranslational modification] 196620005646 intermolecular recognition site; other site 196620005647 dimerization interface [polypeptide binding]; other site 196620005648 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196620005649 DNA binding residues [nucleotide binding] 196620005650 dimerization interface [polypeptide binding]; other site 196620005651 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 196620005652 GAF domain; Region: GAF_3; pfam13492 196620005653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 196620005654 Histidine kinase; Region: HisKA_3; pfam07730 196620005655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620005656 ATP binding site [chemical binding]; other site 196620005657 Mg2+ binding site [ion binding]; other site 196620005658 G-X-G motif; other site 196620005659 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 196620005660 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 196620005661 active site 196620005662 fumarate hydratase; Reviewed; Region: fumC; PRK00485 196620005663 Class II fumarases; Region: Fumarase_classII; cd01362 196620005664 active site 196620005665 tetramer interface [polypeptide binding]; other site 196620005666 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 196620005667 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 196620005668 active site 196620005669 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 196620005670 epoxyqueuosine reductase; Region: TIGR00276 196620005671 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 196620005672 HEAT repeats; Region: HEAT_2; pfam13646 196620005673 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 196620005674 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 196620005675 Walker A/P-loop; other site 196620005676 ATP binding site [chemical binding]; other site 196620005677 Q-loop/lid; other site 196620005678 ABC transporter signature motif; other site 196620005679 Walker B; other site 196620005680 D-loop; other site 196620005681 H-loop/switch region; other site 196620005682 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 196620005683 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 196620005684 substrate binding pocket [chemical binding]; other site 196620005685 membrane-bound complex binding site; other site 196620005686 hinge residues; other site 196620005687 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 196620005688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620005689 dimer interface [polypeptide binding]; other site 196620005690 conserved gate region; other site 196620005691 putative PBP binding loops; other site 196620005692 ABC-ATPase subunit interface; other site 196620005693 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 196620005694 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 196620005695 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 196620005696 metal binding site 2 [ion binding]; metal-binding site 196620005697 putative DNA binding helix; other site 196620005698 metal binding site 1 [ion binding]; metal-binding site 196620005699 dimer interface [polypeptide binding]; other site 196620005700 structural Zn2+ binding site [ion binding]; other site 196620005701 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 196620005702 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 196620005703 putative ligand binding site [chemical binding]; other site 196620005704 NAD binding site [chemical binding]; other site 196620005705 catalytic site [active] 196620005706 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 196620005707 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 196620005708 catalytic triad [active] 196620005709 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 196620005710 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196620005711 inhibitor-cofactor binding pocket; inhibition site 196620005712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620005713 catalytic residue [active] 196620005714 Predicted membrane protein [Function unknown]; Region: COG4129 196620005715 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 196620005716 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196620005717 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196620005718 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 196620005719 Walker A/P-loop; other site 196620005720 ATP binding site [chemical binding]; other site 196620005721 Q-loop/lid; other site 196620005722 ABC transporter signature motif; other site 196620005723 Walker B; other site 196620005724 D-loop; other site 196620005725 H-loop/switch region; other site 196620005726 hypothetical protein; Provisional; Region: PRK13662 196620005727 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 196620005728 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 196620005729 minor groove reading motif; other site 196620005730 helix-hairpin-helix signature motif; other site 196620005731 substrate binding pocket [chemical binding]; other site 196620005732 active site 196620005733 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 196620005734 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 196620005735 DNA binding and oxoG recognition site [nucleotide binding] 196620005736 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 196620005737 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 196620005738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196620005739 Walker A/P-loop; other site 196620005740 ATP binding site [chemical binding]; other site 196620005741 Q-loop/lid; other site 196620005742 ABC transporter signature motif; other site 196620005743 Walker B; other site 196620005744 H-loop/switch region; other site 196620005745 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 196620005746 recombination regulator RecX; Provisional; Region: recX; PRK14135 196620005747 glycosyltransferase; Provisional; Region: PRK13481 196620005748 Transglycosylase; Region: Transgly; pfam00912 196620005749 intracellular protease, PfpI family; Region: PfpI; TIGR01382 196620005750 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 196620005751 proposed catalytic triad [active] 196620005752 conserved cys residue [active] 196620005753 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 196620005754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196620005755 FeS/SAM binding site; other site 196620005756 YfkB-like domain; Region: YfkB; pfam08756 196620005757 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 196620005758 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 196620005759 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 196620005760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 196620005761 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 196620005762 Low molecular weight phosphatase family; Region: LMWPc; cd00115 196620005763 active site 196620005764 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 196620005765 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196620005766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620005767 active site 196620005768 phosphorylation site [posttranslational modification] 196620005769 intermolecular recognition site; other site 196620005770 dimerization interface [polypeptide binding]; other site 196620005771 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196620005772 DNA binding residues [nucleotide binding] 196620005773 dimerization interface [polypeptide binding]; other site 196620005774 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 196620005775 Histidine kinase; Region: HisKA_3; pfam07730 196620005776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620005777 ATP binding site [chemical binding]; other site 196620005778 Mg2+ binding site [ion binding]; other site 196620005779 G-X-G motif; other site 196620005780 Predicted membrane protein [Function unknown]; Region: COG4758 196620005781 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 196620005782 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 196620005783 active site 196620005784 Predicted membrane protein [Function unknown]; Region: COG4129 196620005785 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 196620005786 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 196620005787 catalytic triad [active] 196620005788 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 196620005789 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 196620005790 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 196620005791 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 196620005792 Ferritin-like domain; Region: Ferritin; pfam00210 196620005793 ferroxidase diiron center [ion binding]; other site 196620005794 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 196620005795 active site 196620005796 catalytic site [active] 196620005797 substrate binding site [chemical binding]; other site 196620005798 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 196620005799 active site 196620005800 DNA polymerase IV; Validated; Region: PRK02406 196620005801 DNA binding site [nucleotide binding] 196620005802 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 196620005803 TRAM domain; Region: TRAM; cl01282 196620005804 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 196620005805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620005806 S-adenosylmethionine binding site [chemical binding]; other site 196620005807 putative lipid kinase; Reviewed; Region: PRK13337 196620005808 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 196620005809 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 196620005810 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 196620005811 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 196620005812 GatB domain; Region: GatB_Yqey; pfam02637 196620005813 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 196620005814 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 196620005815 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 196620005816 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 196620005817 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 196620005818 Na binding site [ion binding]; other site 196620005819 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 196620005820 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 196620005821 putative dimer interface [polypeptide binding]; other site 196620005822 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 196620005823 putative dimer interface [polypeptide binding]; other site 196620005824 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 196620005825 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 196620005826 nucleotide binding pocket [chemical binding]; other site 196620005827 K-X-D-G motif; other site 196620005828 catalytic site [active] 196620005829 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 196620005830 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 196620005831 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 196620005832 Dimer interface [polypeptide binding]; other site 196620005833 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 196620005834 Part of AAA domain; Region: AAA_19; pfam13245 196620005835 Family description; Region: UvrD_C_2; pfam13538 196620005836 PcrB family; Region: PcrB; pfam01884 196620005837 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 196620005838 substrate binding site [chemical binding]; other site 196620005839 putative active site [active] 196620005840 dimer interface [polypeptide binding]; other site 196620005841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 196620005842 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 196620005843 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 196620005844 tetramer interface [polypeptide binding]; other site 196620005845 active site 196620005846 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 196620005847 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 196620005848 Staphostatin A; Region: Staphostatin_A; pfam09022 196620005849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 196620005850 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 196620005851 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 196620005852 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 196620005853 homodimer interface [polypeptide binding]; other site 196620005854 NAD binding pocket [chemical binding]; other site 196620005855 ATP binding pocket [chemical binding]; other site 196620005856 Mg binding site [ion binding]; other site 196620005857 active-site loop [active] 196620005858 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 196620005859 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 196620005860 active site 196620005861 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 196620005862 active site 196620005863 dimer interface [polypeptide binding]; other site 196620005864 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 196620005865 Prephenate dehydratase; Region: PDT; pfam00800 196620005866 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 196620005867 putative L-Phe binding site [chemical binding]; other site 196620005868 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 196620005869 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 196620005870 transmembrane helices; other site 196620005871 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 196620005872 Isochorismatase family; Region: Isochorismatase; pfam00857 196620005873 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 196620005874 catalytic triad [active] 196620005875 conserved cis-peptide bond; other site 196620005876 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 196620005877 DHH family; Region: DHH; pfam01368 196620005878 DHHA2 domain; Region: DHHA2; pfam02833 196620005879 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 196620005880 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 196620005881 NAD(P) binding site [chemical binding]; other site 196620005882 catalytic residues [active] 196620005883 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 196620005884 YolD-like protein; Region: YolD; pfam08863 196620005885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 196620005886 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 196620005887 active site 196620005888 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 196620005889 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 196620005890 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 196620005891 Bacterial PH domain; Region: DUF304; cl01348 196620005892 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 196620005893 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196620005894 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 196620005895 Walker A/P-loop; other site 196620005896 ATP binding site [chemical binding]; other site 196620005897 Q-loop/lid; other site 196620005898 ABC transporter signature motif; other site 196620005899 Walker B; other site 196620005900 D-loop; other site 196620005901 H-loop/switch region; other site 196620005902 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 196620005903 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196620005904 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 196620005905 Walker A/P-loop; other site 196620005906 ATP binding site [chemical binding]; other site 196620005907 Q-loop/lid; other site 196620005908 ABC transporter signature motif; other site 196620005909 Walker B; other site 196620005910 D-loop; other site 196620005911 H-loop/switch region; other site 196620005912 Predicted transcriptional regulators [Transcription]; Region: COG1725 196620005913 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196620005914 DNA-binding site [nucleotide binding]; DNA binding site 196620005915 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 196620005916 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196620005917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620005918 homodimer interface [polypeptide binding]; other site 196620005919 catalytic residue [active] 196620005920 MAP domain; Region: MAP; pfam03642 196620005921 MAP domain; Region: MAP; pfam03642 196620005922 MAP domain; Region: MAP; pfam03642 196620005923 MAP domain; Region: MAP; pfam03642 196620005924 MAP domain; Region: MAP; pfam03642 196620005925 MAP domain; Region: MAP; pfam03642 196620005926 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 196620005927 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 196620005928 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 196620005929 CHAP domain; Region: CHAP; pfam05257 196620005930 Small integral membrane protein [Function unknown]; Region: COG5546 196620005931 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 196620005932 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620005933 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 196620005934 Ligand-gated ion channel; Region: Lig_chan; pfam00060 196620005935 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 196620005936 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 196620005937 TolA protein; Region: tolA_full; TIGR02794 196620005938 Phage tail protein; Region: Sipho_tail; cl17486 196620005939 Phage tail protein; Region: Sipho_tail; cl17486 196620005940 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 196620005941 Phage-related protein [Function unknown]; Region: COG5412 196620005942 Peptidase family M23; Region: Peptidase_M23; pfam01551 196620005943 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 196620005944 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 196620005945 N-acetyl-D-glucosamine binding site [chemical binding]; other site 196620005946 catalytic residue [active] 196620005947 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 196620005948 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 196620005949 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 196620005950 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 196620005951 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 196620005952 oligomerization interface [polypeptide binding]; other site 196620005953 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 196620005954 Phage capsid family; Region: Phage_capsid; pfam05065 196620005955 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 196620005956 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 196620005957 Phage-related protein [Function unknown]; Region: COG4695; cl01923 196620005958 Phage Terminase; Region: Terminase_1; pfam03354 196620005959 Phage terminase, small subunit; Region: Terminase_4; pfam05119 196620005960 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 196620005961 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196620005962 active site 196620005963 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 196620005964 putative metal binding site [ion binding]; other site 196620005965 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 196620005966 Transcriptional activator RinB; Region: RinB; pfam06116 196620005967 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 196620005968 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 196620005969 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 196620005970 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 196620005971 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 196620005972 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 196620005973 dimer interface [polypeptide binding]; other site 196620005974 ssDNA binding site [nucleotide binding]; other site 196620005975 tetramer (dimer of dimers) interface [polypeptide binding]; other site 196620005976 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 196620005977 RecT family; Region: RecT; pfam03837 196620005978 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 196620005979 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 196620005980 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 196620005981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 196620005982 AntA/AntB antirepressor; Region: AntA; cl01430 196620005983 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 196620005984 Protein of unknown function (DUF739); Region: DUF739; pfam05339 196620005985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196620005986 non-specific DNA binding site [nucleotide binding]; other site 196620005987 salt bridge; other site 196620005988 sequence-specific DNA binding site [nucleotide binding]; other site 196620005989 Predicted transcriptional regulator [Transcription]; Region: COG2932 196620005990 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 196620005991 Catalytic site [active] 196620005992 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 196620005993 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620005994 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 196620005995 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 196620005996 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 196620005997 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 196620005998 Int/Topo IB signature motif; other site 196620005999 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 196620006000 putative catalytic site [active] 196620006001 phosphate binding site [ion binding]; other site 196620006002 metal binding site A [ion binding]; metal-binding site 196620006003 metal binding site C [ion binding]; metal-binding site 196620006004 metal binding site B [ion binding]; metal-binding site 196620006005 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 196620006006 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 196620006007 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 196620006008 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 196620006009 metal binding site [ion binding]; metal-binding site 196620006010 dimer interface [polypeptide binding]; other site 196620006011 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 196620006012 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 196620006013 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 196620006014 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 196620006015 putative ligand binding residues [chemical binding]; other site 196620006016 Cation transport protein; Region: TrkH; cl17365 196620006017 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 196620006018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620006019 Coenzyme A binding pocket [chemical binding]; other site 196620006020 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 196620006021 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 196620006022 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 196620006023 Int/Topo IB signature motif; other site 196620006024 DNA binding site [nucleotide binding] 196620006025 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 196620006026 DNA binding site [nucleotide binding] 196620006027 active site 196620006028 Int/Topo IB signature motif; other site 196620006029 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 196620006030 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 196620006031 ring oligomerisation interface [polypeptide binding]; other site 196620006032 ATP/Mg binding site [chemical binding]; other site 196620006033 stacking interactions; other site 196620006034 hinge regions; other site 196620006035 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 196620006036 oligomerisation interface [polypeptide binding]; other site 196620006037 mobile loop; other site 196620006038 roof hairpin; other site 196620006039 CAAX protease self-immunity; Region: Abi; pfam02517 196620006040 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 196620006041 dimer interface [polypeptide binding]; other site 196620006042 FMN binding site [chemical binding]; other site 196620006043 Predicted amidohydrolase [General function prediction only]; Region: COG0388 196620006044 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 196620006045 putative active site [active] 196620006046 catalytic triad [active] 196620006047 putative dimer interface [polypeptide binding]; other site 196620006048 delta-hemolysin; Provisional; Region: PRK14752 196620006049 Accessory gene regulator B; Region: AgrB; smart00793 196620006050 Staphylococcal AgrD protein; Region: AgrD; smart00794 196620006051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620006052 Mg2+ binding site [ion binding]; other site 196620006053 G-X-G motif; other site 196620006054 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 196620006055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620006056 active site 196620006057 phosphorylation site [posttranslational modification] 196620006058 intermolecular recognition site; other site 196620006059 dimerization interface [polypeptide binding]; other site 196620006060 LytTr DNA-binding domain; Region: LytTR; pfam04397 196620006061 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 196620006062 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 196620006063 putative substrate binding site [chemical binding]; other site 196620006064 putative ATP binding site [chemical binding]; other site 196620006065 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 196620006066 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 196620006067 substrate binding [chemical binding]; other site 196620006068 active site 196620006069 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 196620006070 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196620006071 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196620006072 DNA binding site [nucleotide binding] 196620006073 domain linker motif; other site 196620006074 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 196620006075 dimerization interface [polypeptide binding]; other site 196620006076 ligand binding site [chemical binding]; other site 196620006077 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 196620006078 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 196620006079 CPxP motif; other site 196620006080 Predicted transporter component [General function prediction only]; Region: COG2391 196620006081 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 196620006082 Sulphur transport; Region: Sulf_transp; pfam04143 196620006083 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 196620006084 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 196620006085 CoA binding domain; Region: CoA_binding; pfam02629 196620006086 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 196620006087 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196620006088 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196620006089 ABC transporter; Region: ABC_tran_2; pfam12848 196620006090 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196620006091 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 196620006092 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 196620006093 Walker A/P-loop; other site 196620006094 ATP binding site [chemical binding]; other site 196620006095 Q-loop/lid; other site 196620006096 ABC transporter signature motif; other site 196620006097 Walker B; other site 196620006098 D-loop; other site 196620006099 H-loop/switch region; other site 196620006100 UGMP family protein; Validated; Region: PRK09604 196620006101 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 196620006102 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 196620006103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620006104 Coenzyme A binding pocket [chemical binding]; other site 196620006105 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 196620006106 Glycoprotease family; Region: Peptidase_M22; pfam00814 196620006107 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 196620006108 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 196620006109 6-phosphogluconate dehydratase; Region: edd; TIGR01196 196620006110 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 196620006111 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 196620006112 PYR/PP interface [polypeptide binding]; other site 196620006113 dimer interface [polypeptide binding]; other site 196620006114 TPP binding site [chemical binding]; other site 196620006115 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 196620006116 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 196620006117 TPP-binding site [chemical binding]; other site 196620006118 dimer interface [polypeptide binding]; other site 196620006119 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 196620006120 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 196620006121 ketol-acid reductoisomerase; Provisional; Region: PRK05479 196620006122 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 196620006123 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 196620006124 2-isopropylmalate synthase; Validated; Region: PRK00915 196620006125 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 196620006126 active site 196620006127 catalytic residues [active] 196620006128 metal binding site [ion binding]; metal-binding site 196620006129 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 196620006130 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 196620006131 tartrate dehydrogenase; Region: TTC; TIGR02089 196620006132 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 196620006133 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 196620006134 substrate binding site [chemical binding]; other site 196620006135 ligand binding site [chemical binding]; other site 196620006136 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 196620006137 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 196620006138 substrate binding site [chemical binding]; other site 196620006139 threonine dehydratase; Validated; Region: PRK08639 196620006140 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 196620006141 tetramer interface [polypeptide binding]; other site 196620006142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620006143 catalytic residue [active] 196620006144 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 196620006145 putative Ile/Val binding site [chemical binding]; other site 196620006146 hypothetical protein; Provisional; Region: PRK04351 196620006147 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 196620006148 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 196620006149 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 196620006150 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 196620006151 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 196620006152 RNA binding site [nucleotide binding]; other site 196620006153 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 196620006154 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196620006155 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 196620006156 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196620006157 DNA binding residues [nucleotide binding] 196620006158 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 196620006159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620006160 ATP binding site [chemical binding]; other site 196620006161 Mg2+ binding site [ion binding]; other site 196620006162 G-X-G motif; other site 196620006163 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 196620006164 anti sigma factor interaction site; other site 196620006165 regulatory phosphorylation site [posttranslational modification]; other site 196620006166 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 196620006167 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 196620006168 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 196620006169 PemK-like protein; Region: PemK; pfam02452 196620006170 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 196620006171 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 196620006172 active site 196620006173 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196620006174 dimer interface [polypeptide binding]; other site 196620006175 substrate binding site [chemical binding]; other site 196620006176 catalytic residues [active] 196620006177 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 196620006178 Uncharacterized conserved protein [Function unknown]; Region: COG3402 196620006179 Predicted membrane protein [Function unknown]; Region: COG3428 196620006180 Bacterial PH domain; Region: DUF304; pfam03703 196620006181 Bacterial PH domain; Region: DUF304; pfam03703 196620006182 Bacterial PH domain; Region: DUF304; cl01348 196620006183 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 196620006184 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 196620006185 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196620006186 Soluble P-type ATPase [General function prediction only]; Region: COG4087 196620006187 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 196620006188 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 196620006189 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 196620006190 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 196620006191 Ligand Binding Site [chemical binding]; other site 196620006192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196620006193 dimer interface [polypeptide binding]; other site 196620006194 phosphorylation site [posttranslational modification] 196620006195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620006196 ATP binding site [chemical binding]; other site 196620006197 Mg2+ binding site [ion binding]; other site 196620006198 G-X-G motif; other site 196620006199 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196620006200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620006201 active site 196620006202 phosphorylation site [posttranslational modification] 196620006203 intermolecular recognition site; other site 196620006204 dimerization interface [polypeptide binding]; other site 196620006205 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196620006206 DNA binding site [nucleotide binding] 196620006207 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 196620006208 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 196620006209 ATP binding site [chemical binding]; other site 196620006210 Mg++ binding site [ion binding]; other site 196620006211 motif III; other site 196620006212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196620006213 nucleotide binding region [chemical binding]; other site 196620006214 ATP-binding site [chemical binding]; other site 196620006215 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 196620006216 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 196620006217 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 196620006218 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 196620006219 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 196620006220 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 196620006221 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 196620006222 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 196620006223 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 196620006224 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 196620006225 putative homodimer interface [polypeptide binding]; other site 196620006226 putative homotetramer interface [polypeptide binding]; other site 196620006227 allosteric switch controlling residues; other site 196620006228 putative metal binding site [ion binding]; other site 196620006229 putative homodimer-homodimer interface [polypeptide binding]; other site 196620006230 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 196620006231 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 196620006232 putative active site [active] 196620006233 catalytic site [active] 196620006234 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 196620006235 putative active site [active] 196620006236 catalytic site [active] 196620006237 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 196620006238 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 196620006239 Zn2+ binding site [ion binding]; other site 196620006240 Mg2+ binding site [ion binding]; other site 196620006241 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 196620006242 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 196620006243 thiamine phosphate binding site [chemical binding]; other site 196620006244 active site 196620006245 pyrophosphate binding site [ion binding]; other site 196620006246 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 196620006247 substrate binding site [chemical binding]; other site 196620006248 multimerization interface [polypeptide binding]; other site 196620006249 ATP binding site [chemical binding]; other site 196620006250 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 196620006251 dimer interface [polypeptide binding]; other site 196620006252 substrate binding site [chemical binding]; other site 196620006253 ATP binding site [chemical binding]; other site 196620006254 thiaminase II; Region: salvage_TenA; TIGR04306 196620006255 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 196620006256 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 196620006257 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 196620006258 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 196620006259 dimer interface [polypeptide binding]; other site 196620006260 ssDNA binding site [nucleotide binding]; other site 196620006261 tetramer (dimer of dimers) interface [polypeptide binding]; other site 196620006262 YwpF-like protein; Region: YwpF; pfam14183 196620006263 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 196620006264 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 196620006265 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 196620006266 hinge; other site 196620006267 active site 196620006268 Predicted membrane protein [Function unknown]; Region: COG4836 196620006269 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 196620006270 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 196620006271 gamma subunit interface [polypeptide binding]; other site 196620006272 epsilon subunit interface [polypeptide binding]; other site 196620006273 LBP interface [polypeptide binding]; other site 196620006274 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 196620006275 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 196620006276 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 196620006277 alpha subunit interaction interface [polypeptide binding]; other site 196620006278 Walker A motif; other site 196620006279 ATP binding site [chemical binding]; other site 196620006280 Walker B motif; other site 196620006281 inhibitor binding site; inhibition site 196620006282 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 196620006283 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 196620006284 core domain interface [polypeptide binding]; other site 196620006285 delta subunit interface [polypeptide binding]; other site 196620006286 epsilon subunit interface [polypeptide binding]; other site 196620006287 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 196620006288 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 196620006289 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 196620006290 beta subunit interaction interface [polypeptide binding]; other site 196620006291 Walker A motif; other site 196620006292 ATP binding site [chemical binding]; other site 196620006293 Walker B motif; other site 196620006294 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 196620006295 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 196620006296 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 196620006297 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 196620006298 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 196620006299 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 196620006300 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 196620006301 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 196620006302 Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468 196620006303 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 196620006304 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 196620006305 active site 196620006306 homodimer interface [polypeptide binding]; other site 196620006307 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196620006308 active site 196620006309 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 196620006310 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 196620006311 dimer interface [polypeptide binding]; other site 196620006312 active site 196620006313 glycine-pyridoxal phosphate binding site [chemical binding]; other site 196620006314 folate binding site [chemical binding]; other site 196620006315 hypothetical protein; Provisional; Region: PRK13690 196620006316 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 196620006317 Low molecular weight phosphatase family; Region: LMWPc; cd00115 196620006318 active site 196620006319 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 196620006320 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 196620006321 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 196620006322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620006323 S-adenosylmethionine binding site [chemical binding]; other site 196620006324 peptide chain release factor 1; Validated; Region: prfA; PRK00591 196620006325 This domain is found in peptide chain release factors; Region: PCRF; smart00937 196620006326 RF-1 domain; Region: RF-1; pfam00472 196620006327 thymidine kinase; Provisional; Region: PRK04296 196620006328 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 196620006329 transcription termination factor Rho; Provisional; Region: rho; PRK09376 196620006330 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 196620006331 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 196620006332 RNA binding site [nucleotide binding]; other site 196620006333 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 196620006334 multimer interface [polypeptide binding]; other site 196620006335 Walker A motif; other site 196620006336 ATP binding site [chemical binding]; other site 196620006337 Walker B motif; other site 196620006338 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 196620006339 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 196620006340 NAD binding site [chemical binding]; other site 196620006341 catalytic residues [active] 196620006342 Predicted transcriptional regulators [Transcription]; Region: COG1733 196620006343 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 196620006344 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 196620006345 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 196620006346 hinge; other site 196620006347 active site 196620006348 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 196620006349 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 196620006350 intersubunit interface [polypeptide binding]; other site 196620006351 active site 196620006352 zinc binding site [ion binding]; other site 196620006353 Na+ binding site [ion binding]; other site 196620006354 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 196620006355 CTP synthetase; Validated; Region: pyrG; PRK05380 196620006356 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 196620006357 Catalytic site [active] 196620006358 active site 196620006359 UTP binding site [chemical binding]; other site 196620006360 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 196620006361 active site 196620006362 putative oxyanion hole; other site 196620006363 catalytic triad [active] 196620006364 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 196620006365 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 196620006366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620006367 Coenzyme A binding pocket [chemical binding]; other site 196620006368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 196620006369 Coenzyme A binding pocket [chemical binding]; other site 196620006370 pantothenate kinase; Provisional; Region: PRK13317 196620006371 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 196620006372 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 196620006373 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 196620006374 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 196620006375 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 196620006376 metal binding site [ion binding]; metal-binding site 196620006377 S-ribosylhomocysteinase; Provisional; Region: PRK02260 196620006378 Predicted membrane protein [Function unknown]; Region: COG4270 196620006379 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 196620006380 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 196620006381 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 196620006382 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 196620006383 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 196620006384 intersubunit interface [polypeptide binding]; other site 196620006385 active site 196620006386 catalytic residue [active] 196620006387 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 196620006388 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 196620006389 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 196620006390 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 196620006391 dimerization interface [polypeptide binding]; other site 196620006392 DPS ferroxidase diiron center [ion binding]; other site 196620006393 ion pore; other site 196620006394 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 196620006395 EVE domain; Region: EVE; cl00728 196620006396 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 196620006397 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 196620006398 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 196620006399 NADH(P)-binding; Region: NAD_binding_10; pfam13460 196620006400 NAD(P) binding site [chemical binding]; other site 196620006401 putative active site [active] 196620006402 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196620006403 dimerization interface [polypeptide binding]; other site 196620006404 putative DNA binding site [nucleotide binding]; other site 196620006405 putative Zn2+ binding site [ion binding]; other site 196620006406 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 196620006407 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 196620006408 similar to hypothetical protein 196620006409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 196620006410 Cytoadherence-linked asexual protein; Region: CLAG; pfam03805 196620006411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 196620006412 Syndecan domain; Region: Syndecan; pfam01034 196620006413 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 196620006414 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620006415 active site 196620006416 motif I; other site 196620006417 motif II; other site 196620006418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620006419 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 196620006420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196620006421 Walker A/P-loop; other site 196620006422 ATP binding site [chemical binding]; other site 196620006423 Q-loop/lid; other site 196620006424 ABC transporter signature motif; other site 196620006425 Walker B; other site 196620006426 D-loop; other site 196620006427 H-loop/switch region; other site 196620006428 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 196620006429 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 196620006430 glutaminase active site [active] 196620006431 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 196620006432 dimer interface [polypeptide binding]; other site 196620006433 active site 196620006434 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 196620006435 dimer interface [polypeptide binding]; other site 196620006436 active site 196620006437 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 196620006438 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 196620006439 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 196620006440 active site 196620006441 P-loop; other site 196620006442 phosphorylation site [posttranslational modification] 196620006443 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 196620006444 HTH domain; Region: HTH_11; pfam08279 196620006445 Mga helix-turn-helix domain; Region: Mga; pfam05043 196620006446 PRD domain; Region: PRD; pfam00874 196620006447 PRD domain; Region: PRD; pfam00874 196620006448 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 196620006449 active site 196620006450 P-loop; other site 196620006451 phosphorylation site [posttranslational modification] 196620006452 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 196620006453 active site 196620006454 phosphorylation site [posttranslational modification] 196620006455 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 196620006456 active site 196620006457 phosphorylation site [posttranslational modification] 196620006458 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 196620006459 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 196620006460 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 196620006461 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620006462 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 196620006463 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 196620006464 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620006465 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620006466 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620006467 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620006468 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620006469 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 196620006470 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 196620006471 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 196620006472 active site 196620006473 substrate binding site [chemical binding]; other site 196620006474 metal binding site [ion binding]; metal-binding site 196620006475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 196620006476 YbbR-like protein; Region: YbbR; pfam07949 196620006477 TIGR00159 family protein; Region: TIGR00159 196620006478 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 196620006479 Arginase family; Region: Arginase; cd09989 196620006480 active site 196620006481 Mn binding site [ion binding]; other site 196620006482 oligomer interface [polypeptide binding]; other site 196620006483 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 196620006484 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 196620006485 Walker A motif; other site 196620006486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620006487 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196620006488 putative substrate translocation pore; other site 196620006489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620006490 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196620006491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620006492 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 196620006493 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 196620006494 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 196620006495 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 196620006496 substrate binding site; other site 196620006497 dimerization interface; other site 196620006498 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 196620006499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 196620006500 Nucleoside recognition; Region: Gate; pfam07670 196620006501 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 196620006502 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196620006503 ABC-ATPase subunit interface; other site 196620006504 dimer interface [polypeptide binding]; other site 196620006505 putative PBP binding regions; other site 196620006506 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 196620006507 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196620006508 ABC-ATPase subunit interface; other site 196620006509 dimer interface [polypeptide binding]; other site 196620006510 putative PBP binding regions; other site 196620006511 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 196620006512 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 196620006513 siderophore binding site; other site 196620006514 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 196620006515 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 196620006516 dimer interface [polypeptide binding]; other site 196620006517 active site 196620006518 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196620006519 substrate binding site [chemical binding]; other site 196620006520 catalytic residue [active] 196620006521 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 196620006522 IucA / IucC family; Region: IucA_IucC; pfam04183 196620006523 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 196620006524 H+ Antiporter protein; Region: 2A0121; TIGR00900 196620006525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620006526 putative substrate translocation pore; other site 196620006527 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 196620006528 IucA / IucC family; Region: IucA_IucC; pfam04183 196620006529 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 196620006530 Asp23 family; Region: Asp23; pfam03780 196620006531 Small integral membrane protein [Function unknown]; Region: COG5547 196620006532 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 196620006533 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 196620006534 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 196620006535 putative NAD(P) binding site [chemical binding]; other site 196620006536 dimer interface [polypeptide binding]; other site 196620006537 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 196620006538 Prostaglandin dehydrogenases; Region: PGDH; cd05288 196620006539 NAD(P) binding site [chemical binding]; other site 196620006540 substrate binding site [chemical binding]; other site 196620006541 dimer interface [polypeptide binding]; other site 196620006542 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 196620006543 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 196620006544 beta-galactosidase; Region: BGL; TIGR03356 196620006545 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 196620006546 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 196620006547 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 196620006548 active site 196620006549 P-loop; other site 196620006550 phosphorylation site [posttranslational modification] 196620006551 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 196620006552 methionine cluster; other site 196620006553 active site 196620006554 phosphorylation site [posttranslational modification] 196620006555 metal binding site [ion binding]; metal-binding site 196620006556 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 196620006557 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 196620006558 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 196620006559 putative substrate binding site [chemical binding]; other site 196620006560 putative ATP binding site [chemical binding]; other site 196620006561 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 196620006562 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 196620006563 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 196620006564 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 196620006565 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 196620006566 NAD-dependent deacetylase; Provisional; Region: PRK00481 196620006567 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 196620006568 NAD+ binding site [chemical binding]; other site 196620006569 substrate binding site [chemical binding]; other site 196620006570 putative Zn binding site [ion binding]; other site 196620006571 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 196620006572 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196620006573 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 196620006574 active site 196620006575 catalytic tetrad [active] 196620006576 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 196620006577 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 196620006578 DNA binding residues [nucleotide binding] 196620006579 putative dimer interface [polypeptide binding]; other site 196620006580 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 196620006581 substrate binding site [chemical binding]; other site 196620006582 catalytic residues [active] 196620006583 MAP domain; Region: MAP; pfam03642 196620006584 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 196620006585 acetolactate synthase; Reviewed; Region: PRK08617 196620006586 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 196620006587 PYR/PP interface [polypeptide binding]; other site 196620006588 dimer interface [polypeptide binding]; other site 196620006589 TPP binding site [chemical binding]; other site 196620006590 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 196620006591 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 196620006592 TPP-binding site [chemical binding]; other site 196620006593 similar to hypothetical protein 196620006594 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 196620006595 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 196620006596 23S rRNA interface [nucleotide binding]; other site 196620006597 L3 interface [polypeptide binding]; other site 196620006598 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 196620006599 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 196620006600 dimerization interface 3.5A [polypeptide binding]; other site 196620006601 active site 196620006602 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 196620006603 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 196620006604 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 196620006605 Walker A/P-loop; other site 196620006606 ATP binding site [chemical binding]; other site 196620006607 Q-loop/lid; other site 196620006608 ABC transporter signature motif; other site 196620006609 Walker B; other site 196620006610 D-loop; other site 196620006611 H-loop/switch region; other site 196620006612 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 196620006613 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 196620006614 Walker A/P-loop; other site 196620006615 ATP binding site [chemical binding]; other site 196620006616 Q-loop/lid; other site 196620006617 ABC transporter signature motif; other site 196620006618 Walker B; other site 196620006619 D-loop; other site 196620006620 H-loop/switch region; other site 196620006621 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 196620006622 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 196620006623 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 196620006624 alphaNTD homodimer interface [polypeptide binding]; other site 196620006625 alphaNTD - beta interaction site [polypeptide binding]; other site 196620006626 alphaNTD - beta' interaction site [polypeptide binding]; other site 196620006627 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 196620006628 30S ribosomal protein S11; Validated; Region: PRK05309 196620006629 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 196620006630 30S ribosomal protein S13; Region: bact_S13; TIGR03631 196620006631 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 196620006632 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 196620006633 rRNA binding site [nucleotide binding]; other site 196620006634 predicted 30S ribosome binding site; other site 196620006635 adenylate kinase; Reviewed; Region: adk; PRK00279 196620006636 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 196620006637 AMP-binding site [chemical binding]; other site 196620006638 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 196620006639 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 196620006640 SecY translocase; Region: SecY; pfam00344 196620006641 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 196620006642 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 196620006643 23S rRNA binding site [nucleotide binding]; other site 196620006644 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 196620006645 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 196620006646 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 196620006647 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 196620006648 5S rRNA interface [nucleotide binding]; other site 196620006649 L27 interface [polypeptide binding]; other site 196620006650 23S rRNA interface [nucleotide binding]; other site 196620006651 L5 interface [polypeptide binding]; other site 196620006652 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 196620006653 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 196620006654 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 196620006655 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 196620006656 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 196620006657 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 196620006658 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 196620006659 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 196620006660 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 196620006661 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 196620006662 RNA binding site [nucleotide binding]; other site 196620006663 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 196620006664 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 196620006665 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 196620006666 23S rRNA interface [nucleotide binding]; other site 196620006667 putative translocon interaction site; other site 196620006668 signal recognition particle (SRP54) interaction site; other site 196620006669 L23 interface [polypeptide binding]; other site 196620006670 trigger factor interaction site; other site 196620006671 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 196620006672 23S rRNA interface [nucleotide binding]; other site 196620006673 5S rRNA interface [nucleotide binding]; other site 196620006674 putative antibiotic binding site [chemical binding]; other site 196620006675 L25 interface [polypeptide binding]; other site 196620006676 L27 interface [polypeptide binding]; other site 196620006677 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 196620006678 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 196620006679 G-X-X-G motif; other site 196620006680 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 196620006681 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 196620006682 putative translocon binding site; other site 196620006683 protein-rRNA interface [nucleotide binding]; other site 196620006684 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 196620006685 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 196620006686 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 196620006687 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 196620006688 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 196620006689 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 196620006690 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 196620006691 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 196620006692 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 196620006693 DNA topoisomerase III; Provisional; Region: PRK07726 196620006694 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 196620006695 active site 196620006696 putative interdomain interaction site [polypeptide binding]; other site 196620006697 putative metal-binding site [ion binding]; other site 196620006698 putative nucleotide binding site [chemical binding]; other site 196620006699 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 196620006700 domain I; other site 196620006701 DNA binding groove [nucleotide binding] 196620006702 phosphate binding site [ion binding]; other site 196620006703 domain II; other site 196620006704 domain III; other site 196620006705 nucleotide binding site [chemical binding]; other site 196620006706 catalytic site [active] 196620006707 domain IV; other site 196620006708 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 196620006709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620006710 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 196620006711 Coenzyme A binding pocket [chemical binding]; other site 196620006712 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 196620006713 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 196620006714 Predicted permeases [General function prediction only]; Region: COG0679 196620006715 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 196620006716 Protein export membrane protein; Region: SecD_SecF; cl14618 196620006717 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 196620006718 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 196620006719 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 196620006720 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 196620006721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620006722 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196620006723 putative substrate translocation pore; other site 196620006724 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 196620006725 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196620006726 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 196620006727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196620006728 FeS/SAM binding site; other site 196620006729 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 196620006730 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 196620006731 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 196620006732 GTP binding site; other site 196620006733 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 196620006734 MoaE interaction surface [polypeptide binding]; other site 196620006735 MoeB interaction surface [polypeptide binding]; other site 196620006736 thiocarboxylated glycine; other site 196620006737 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 196620006738 MoaE homodimer interface [polypeptide binding]; other site 196620006739 MoaD interaction [polypeptide binding]; other site 196620006740 active site residues [active] 196620006741 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 196620006742 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 196620006743 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 196620006744 dimer interface [polypeptide binding]; other site 196620006745 putative functional site; other site 196620006746 putative MPT binding site; other site 196620006747 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 196620006748 trimer interface [polypeptide binding]; other site 196620006749 dimer interface [polypeptide binding]; other site 196620006750 putative active site [active] 196620006751 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 196620006752 MPT binding site; other site 196620006753 trimer interface [polypeptide binding]; other site 196620006754 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 196620006755 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 196620006756 ATP binding site [chemical binding]; other site 196620006757 substrate interface [chemical binding]; other site 196620006758 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196620006759 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 196620006760 Walker A/P-loop; other site 196620006761 ATP binding site [chemical binding]; other site 196620006762 Q-loop/lid; other site 196620006763 ABC transporter signature motif; other site 196620006764 Walker B; other site 196620006765 D-loop; other site 196620006766 H-loop/switch region; other site 196620006767 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 196620006768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620006769 dimer interface [polypeptide binding]; other site 196620006770 conserved gate region; other site 196620006771 putative PBP binding loops; other site 196620006772 ABC-ATPase subunit interface; other site 196620006773 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 196620006774 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 196620006775 substrate binding pocket [chemical binding]; other site 196620006776 membrane-bound complex binding site; other site 196620006777 hinge residues; other site 196620006778 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 196620006779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620006780 Coenzyme A binding pocket [chemical binding]; other site 196620006781 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 196620006782 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 196620006783 active site 196620006784 dimerization interface [polypeptide binding]; other site 196620006785 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 196620006786 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 196620006787 intersubunit interface [polypeptide binding]; other site 196620006788 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 196620006789 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 196620006790 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 196620006791 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 196620006792 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 196620006793 alpha-gamma subunit interface [polypeptide binding]; other site 196620006794 beta-gamma subunit interface [polypeptide binding]; other site 196620006795 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 196620006796 gamma-beta subunit interface [polypeptide binding]; other site 196620006797 alpha-beta subunit interface [polypeptide binding]; other site 196620006798 urease subunit alpha; Reviewed; Region: ureC; PRK13207 196620006799 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 196620006800 subunit interactions [polypeptide binding]; other site 196620006801 active site 196620006802 flap region; other site 196620006803 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 196620006804 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 196620006805 dimer interface [polypeptide binding]; other site 196620006806 catalytic residues [active] 196620006807 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 196620006808 UreF; Region: UreF; pfam01730 196620006809 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 196620006810 UreD urease accessory protein; Region: UreD; cl00530 196620006811 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 196620006812 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 196620006813 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 196620006814 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 196620006815 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 196620006816 Surface antigen [General function prediction only]; Region: COG3942 196620006817 CHAP domain; Region: CHAP; pfam05257 196620006818 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 196620006819 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 196620006820 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 196620006821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 196620006822 Surface antigen [General function prediction only]; Region: COG3942 196620006823 CHAP domain; Region: CHAP; pfam05257 196620006824 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 196620006825 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 196620006826 putative ligand binding site [chemical binding]; other site 196620006827 putative NAD binding site [chemical binding]; other site 196620006828 catalytic site [active] 196620006829 hypothetical protein; Provisional; Region: PRK06753 196620006830 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 196620006831 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 196620006832 Lysozyme subfamily 2; Region: LYZ2; smart00047 196620006833 Uncharacterized conserved protein [Function unknown]; Region: COG2427 196620006834 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 196620006835 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 196620006836 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 196620006837 4Fe-4S binding domain; Region: Fer4; pfam00037 196620006838 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 196620006839 [4Fe-4S] binding site [ion binding]; other site 196620006840 molybdopterin cofactor binding site; other site 196620006841 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 196620006842 molybdopterin cofactor binding site; other site 196620006843 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 196620006844 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 196620006845 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 196620006846 active site 196620006847 Predicted transcriptional regulator [Transcription]; Region: COG2378 196620006848 HTH domain; Region: HTH_11; pfam08279 196620006849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 196620006850 CAAX protease self-immunity; Region: Abi; pfam02517 196620006851 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 196620006852 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 196620006853 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 196620006854 putative active site [active] 196620006855 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 196620006856 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 196620006857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620006858 active site 196620006859 motif I; other site 196620006860 motif II; other site 196620006861 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 196620006862 Sodium Bile acid symporter family; Region: SBF; pfam01758 196620006863 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 196620006864 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 196620006865 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 196620006866 active site turn [active] 196620006867 phosphorylation site [posttranslational modification] 196620006868 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 196620006869 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 196620006870 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 196620006871 putative active site [active] 196620006872 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 196620006873 putative hydrophobic ligand binding site [chemical binding]; other site 196620006874 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 196620006875 oxidoreductase; Provisional; Region: PRK07985 196620006876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196620006877 NAD(P) binding site [chemical binding]; other site 196620006878 active site 196620006879 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 196620006880 amidohydrolase; Region: amidohydrolases; TIGR01891 196620006881 metal binding site [ion binding]; metal-binding site 196620006882 dimer interface [polypeptide binding]; other site 196620006883 imidazolonepropionase; Validated; Region: PRK09356 196620006884 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 196620006885 active site 196620006886 urocanate hydratase; Provisional; Region: PRK05414 196620006887 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196620006888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196620006889 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 196620006890 dimerization interface [polypeptide binding]; other site 196620006891 formimidoylglutamase; Provisional; Region: PRK13775 196620006892 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 196620006893 putative active site [active] 196620006894 putative metal binding site [ion binding]; other site 196620006895 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 196620006896 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 196620006897 tetramer (dimer of dimers) interface [polypeptide binding]; other site 196620006898 active site 196620006899 dimer interface [polypeptide binding]; other site 196620006900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 196620006901 MOSC domain; Region: MOSC; pfam03473 196620006902 3-alpha domain; Region: 3-alpha; pfam03475 196620006903 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 196620006904 active site 196620006905 catalytic residues [active] 196620006906 Uncharacterized conserved protein [Function unknown]; Region: COG1742 196620006907 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 196620006908 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 196620006909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196620006910 Walker A/P-loop; other site 196620006911 ATP binding site [chemical binding]; other site 196620006912 Q-loop/lid; other site 196620006913 ABC transporter signature motif; other site 196620006914 Walker B; other site 196620006915 D-loop; other site 196620006916 H-loop/switch region; other site 196620006917 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 196620006918 Predicted membrane protein [Function unknown]; Region: COG3152 196620006919 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 196620006920 active site 196620006921 DNA binding site [nucleotide binding] 196620006922 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 196620006923 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 196620006924 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 196620006925 homotetramer interface [polypeptide binding]; other site 196620006926 FMN binding site [chemical binding]; other site 196620006927 homodimer contacts [polypeptide binding]; other site 196620006928 putative active site [active] 196620006929 putative substrate binding site [chemical binding]; other site 196620006930 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 196620006931 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 196620006932 oligomer interface [polypeptide binding]; other site 196620006933 metal binding site [ion binding]; metal-binding site 196620006934 metal binding site [ion binding]; metal-binding site 196620006935 putative Cl binding site [ion binding]; other site 196620006936 aspartate ring; other site 196620006937 basic sphincter; other site 196620006938 hydrophobic gate; other site 196620006939 periplasmic entrance; other site 196620006940 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 196620006941 active site 196620006942 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 196620006943 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 196620006944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620006945 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 196620006946 putative substrate translocation pore; other site 196620006947 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 196620006948 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 196620006949 HlyD family secretion protein; Region: HlyD_3; pfam13437 196620006950 lipoyl-biotinyl attachment site [posttranslational modification]; other site 196620006951 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 196620006952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620006953 putative substrate translocation pore; other site 196620006954 Predicted membrane protein [Function unknown]; Region: COG4640 196620006955 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 196620006956 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 196620006957 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196620006958 putative Zn2+ binding site [ion binding]; other site 196620006959 putative DNA binding site [nucleotide binding]; other site 196620006960 Uncharacterized conserved protein [Function unknown]; Region: COG1434 196620006961 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 196620006962 putative active site [active] 196620006963 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196620006964 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 196620006965 Walker A/P-loop; other site 196620006966 ATP binding site [chemical binding]; other site 196620006967 Q-loop/lid; other site 196620006968 ABC transporter signature motif; other site 196620006969 Walker B; other site 196620006970 D-loop; other site 196620006971 H-loop/switch region; other site 196620006972 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 196620006973 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 196620006974 FtsX-like permease family; Region: FtsX; pfam02687 196620006975 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196620006976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620006977 active site 196620006978 phosphorylation site [posttranslational modification] 196620006979 intermolecular recognition site; other site 196620006980 dimerization interface [polypeptide binding]; other site 196620006981 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196620006982 DNA binding site [nucleotide binding] 196620006983 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 196620006984 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196620006985 dimerization interface [polypeptide binding]; other site 196620006986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196620006987 dimer interface [polypeptide binding]; other site 196620006988 phosphorylation site [posttranslational modification] 196620006989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620006990 ATP binding site [chemical binding]; other site 196620006991 Mg2+ binding site [ion binding]; other site 196620006992 G-X-G motif; other site 196620006993 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 196620006994 LytTr DNA-binding domain; Region: LytTR; smart00850 196620006995 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 196620006996 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 196620006997 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 196620006998 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 196620006999 L-lactate permease; Region: Lactate_perm; cl00701 196620007000 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 196620007001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620007002 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 196620007003 Coenzyme A binding pocket [chemical binding]; other site 196620007004 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 196620007005 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 196620007006 NAD(P) binding site [chemical binding]; other site 196620007007 H+ Antiporter protein; Region: 2A0121; TIGR00900 196620007008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620007009 Coenzyme A binding pocket [chemical binding]; other site 196620007010 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 196620007011 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 196620007012 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196620007013 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 196620007014 Predicted membrane protein [Function unknown]; Region: COG1511 196620007015 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 196620007016 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 196620007017 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 196620007018 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 196620007019 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 196620007020 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 196620007021 Cl binding site [ion binding]; other site 196620007022 oligomer interface [polypeptide binding]; other site 196620007023 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 196620007024 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 196620007025 active site turn [active] 196620007026 phosphorylation site [posttranslational modification] 196620007027 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 196620007028 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 196620007029 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 196620007030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 196620007031 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 196620007032 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 196620007033 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 196620007034 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 196620007035 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 196620007036 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 196620007037 MarR family; Region: MarR_2; pfam12802 196620007038 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 196620007039 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 196620007040 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 196620007041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620007042 putative substrate translocation pore; other site 196620007043 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 196620007044 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 196620007045 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 196620007046 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 196620007047 DNA binding residues [nucleotide binding] 196620007048 dimer interface [polypeptide binding]; other site 196620007049 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 196620007050 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196620007051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620007052 active site 196620007053 phosphorylation site [posttranslational modification] 196620007054 intermolecular recognition site; other site 196620007055 dimerization interface [polypeptide binding]; other site 196620007056 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196620007057 DNA binding residues [nucleotide binding] 196620007058 dimerization interface [polypeptide binding]; other site 196620007059 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 196620007060 Histidine kinase; Region: HisKA_3; pfam07730 196620007061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620007062 ATP binding site [chemical binding]; other site 196620007063 Mg2+ binding site [ion binding]; other site 196620007064 G-X-G motif; other site 196620007065 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 196620007066 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 196620007067 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 196620007068 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 196620007069 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 196620007070 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 196620007071 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 196620007072 [4Fe-4S] binding site [ion binding]; other site 196620007073 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 196620007074 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 196620007075 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 196620007076 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 196620007077 molybdopterin cofactor binding site; other site 196620007078 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 196620007079 active site 196620007080 SAM binding site [chemical binding]; other site 196620007081 homodimer interface [polypeptide binding]; other site 196620007082 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 196620007083 [2Fe-2S] cluster binding site [ion binding]; other site 196620007084 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 196620007085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 196620007086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196620007087 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 196620007088 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 196620007089 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 196620007090 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 196620007091 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 196620007092 putative active site [active] 196620007093 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 196620007094 active site 196620007095 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 196620007096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620007097 Coenzyme A binding pocket [chemical binding]; other site 196620007098 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 196620007099 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 196620007100 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 196620007101 putative hydrophobic ligand binding site [chemical binding]; other site 196620007102 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 196620007103 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 196620007104 intersubunit interface [polypeptide binding]; other site 196620007105 YodA lipocalin-like domain; Region: YodA; pfam09223 196620007106 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 196620007107 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 196620007108 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 196620007109 Thioredoxin; Region: Thioredoxin_4; cl17273 196620007110 FemAB family; Region: FemAB; pfam02388 196620007111 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 196620007112 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 196620007113 Walker A/P-loop; other site 196620007114 ATP binding site [chemical binding]; other site 196620007115 Q-loop/lid; other site 196620007116 ABC transporter signature motif; other site 196620007117 Walker B; other site 196620007118 D-loop; other site 196620007119 H-loop/switch region; other site 196620007120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 196620007121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620007122 putative PBP binding loops; other site 196620007123 dimer interface [polypeptide binding]; other site 196620007124 ABC-ATPase subunit interface; other site 196620007125 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 196620007126 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 196620007127 substrate binding pocket [chemical binding]; other site 196620007128 membrane-bound complex binding site; other site 196620007129 hinge residues; other site 196620007130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620007131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196620007132 putative substrate translocation pore; other site 196620007133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620007134 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196620007135 catalytic core [active] 196620007136 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196620007137 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 196620007138 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 196620007139 B domain; Region: B; pfam02216 196620007140 B domain; Region: B; pfam02216 196620007141 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 196620007142 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 196620007143 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 196620007144 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 196620007145 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 196620007146 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 196620007147 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 196620007148 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196620007149 catalytic residue [active] 196620007150 biotin synthase; Validated; Region: PRK06256 196620007151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196620007152 FeS/SAM binding site; other site 196620007153 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 196620007154 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196620007155 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 196620007156 inhibitor-cofactor binding pocket; inhibition site 196620007157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620007158 catalytic residue [active] 196620007159 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 196620007160 AAA domain; Region: AAA_26; pfam13500 196620007161 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 196620007162 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 196620007163 Walker A/P-loop; other site 196620007164 ATP binding site [chemical binding]; other site 196620007165 Q-loop/lid; other site 196620007166 ABC transporter signature motif; other site 196620007167 Walker B; other site 196620007168 D-loop; other site 196620007169 H-loop/switch region; other site 196620007170 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196620007171 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196620007172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196620007173 Walker A/P-loop; other site 196620007174 ATP binding site [chemical binding]; other site 196620007175 Q-loop/lid; other site 196620007176 ABC transporter signature motif; other site 196620007177 Walker B; other site 196620007178 D-loop; other site 196620007179 H-loop/switch region; other site 196620007180 Predicted membrane protein [Function unknown]; Region: COG2246 196620007181 GtrA-like protein; Region: GtrA; pfam04138 196620007182 glycerate kinase; Region: TIGR00045 196620007183 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 196620007184 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 196620007185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620007186 putative substrate translocation pore; other site 196620007187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 196620007188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 196620007189 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 196620007190 putative phosphoesterase; Region: acc_ester; TIGR03729 196620007191 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 196620007192 Spore germination protein; Region: Spore_permease; cl17796 196620007193 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 196620007194 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 196620007195 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 196620007196 Beta-lactamase; Region: Beta-lactamase; pfam00144 196620007197 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 196620007198 extended (e) SDRs; Region: SDR_e; cd08946 196620007199 NAD(P) binding site [chemical binding]; other site 196620007200 active site 196620007201 substrate binding site [chemical binding]; other site 196620007202 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 196620007203 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 196620007204 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 196620007205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620007206 putative substrate translocation pore; other site 196620007207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620007208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620007209 dimer interface [polypeptide binding]; other site 196620007210 conserved gate region; other site 196620007211 ABC-ATPase subunit interface; other site 196620007212 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 196620007213 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 196620007214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620007215 dimer interface [polypeptide binding]; other site 196620007216 conserved gate region; other site 196620007217 putative PBP binding loops; other site 196620007218 ABC-ATPase subunit interface; other site 196620007219 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 196620007220 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 196620007221 Walker A/P-loop; other site 196620007222 ATP binding site [chemical binding]; other site 196620007223 Q-loop/lid; other site 196620007224 ABC transporter signature motif; other site 196620007225 Walker B; other site 196620007226 D-loop; other site 196620007227 H-loop/switch region; other site 196620007228 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 196620007229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 196620007230 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 196620007231 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 196620007232 amino acid transporter; Region: 2A0306; TIGR00909 196620007233 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 196620007234 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 196620007235 substrate binding pocket [chemical binding]; other site 196620007236 catalytic triad [active] 196620007237 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 196620007238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620007239 putative substrate translocation pore; other site 196620007240 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 196620007241 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 196620007242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196620007243 Walker A/P-loop; other site 196620007244 ATP binding site [chemical binding]; other site 196620007245 Q-loop/lid; other site 196620007246 ABC transporter signature motif; other site 196620007247 Walker B; other site 196620007248 D-loop; other site 196620007249 H-loop/switch region; other site 196620007250 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 196620007251 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 196620007252 oligomer interface [polypeptide binding]; other site 196620007253 active site 196620007254 metal binding site [ion binding]; metal-binding site 196620007255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 196620007256 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 196620007257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 196620007258 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 196620007259 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 196620007260 active site 196620007261 FMN binding site [chemical binding]; other site 196620007262 substrate binding site [chemical binding]; other site 196620007263 3Fe-4S cluster binding site [ion binding]; other site 196620007264 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 196620007265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620007266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196620007267 putative substrate translocation pore; other site 196620007268 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 196620007269 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196620007270 Walker A/P-loop; other site 196620007271 ATP binding site [chemical binding]; other site 196620007272 Q-loop/lid; other site 196620007273 ABC transporter signature motif; other site 196620007274 Walker B; other site 196620007275 D-loop; other site 196620007276 H-loop/switch region; other site 196620007277 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196620007278 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 196620007279 Walker A/P-loop; other site 196620007280 ATP binding site [chemical binding]; other site 196620007281 Q-loop/lid; other site 196620007282 ABC transporter signature motif; other site 196620007283 Walker B; other site 196620007284 D-loop; other site 196620007285 H-loop/switch region; other site 196620007286 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196620007287 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 196620007288 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 196620007289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620007290 dimer interface [polypeptide binding]; other site 196620007291 conserved gate region; other site 196620007292 putative PBP binding loops; other site 196620007293 ABC-ATPase subunit interface; other site 196620007294 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 196620007295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196620007296 dimer interface [polypeptide binding]; other site 196620007297 conserved gate region; other site 196620007298 putative PBP binding loops; other site 196620007299 ABC-ATPase subunit interface; other site 196620007300 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 196620007301 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 196620007302 substrate binding site [chemical binding]; other site 196620007303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 196620007304 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 196620007305 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 196620007306 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 196620007307 short chain dehydrogenase; Validated; Region: PRK08589 196620007308 classical (c) SDRs; Region: SDR_c; cd05233 196620007309 NAD(P) binding site [chemical binding]; other site 196620007310 active site 196620007311 AbgT putative transporter family; Region: ABG_transport; cl17431 196620007312 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 196620007313 Uncharacterized conserved protein [Function unknown]; Region: COG2128 196620007314 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 196620007315 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 196620007316 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 196620007317 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 196620007318 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 196620007319 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 196620007320 classical (c) SDRs; Region: SDR_c; cd05233 196620007321 NAD(P) binding site [chemical binding]; other site 196620007322 active site 196620007323 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 196620007324 Protein of unknown function, DUF576; Region: DUF576; pfam04507 196620007325 Protein of unknown function, DUF576; Region: DUF576; pfam04507 196620007326 Protein of unknown function, DUF576; Region: DUF576; pfam04507 196620007327 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 196620007328 PLD-like domain; Region: PLDc_2; pfam13091 196620007329 putative homodimer interface [polypeptide binding]; other site 196620007330 putative active site [active] 196620007331 catalytic site [active] 196620007332 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 196620007333 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196620007334 ATP binding site [chemical binding]; other site 196620007335 putative Mg++ binding site [ion binding]; other site 196620007336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196620007337 nucleotide binding region [chemical binding]; other site 196620007338 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 196620007339 ATP-binding site [chemical binding]; other site 196620007340 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 196620007341 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 196620007342 active site 196620007343 8-oxo-dGMP binding site [chemical binding]; other site 196620007344 nudix motif; other site 196620007345 metal binding site [ion binding]; metal-binding site 196620007346 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 196620007347 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 196620007348 active site 196620007349 substrate binding site [chemical binding]; other site 196620007350 metal binding site [ion binding]; metal-binding site 196620007351 H+ Antiporter protein; Region: 2A0121; TIGR00900 196620007352 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 196620007353 G5 domain; Region: G5; pfam07501 196620007354 G5 domain; Region: G5; pfam07501 196620007355 G5 domain; Region: G5; pfam07501 196620007356 G5 domain; Region: G5; pfam07501 196620007357 G5 domain; Region: G5; pfam07501 196620007358 G5 domain; Region: G5; pfam07501 196620007359 G5 domain; Region: G5; pfam07501 196620007360 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 196620007361 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 196620007362 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 196620007363 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 196620007364 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196620007365 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 196620007366 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 196620007367 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 196620007368 active site 196620007369 tetramer interface; other site 196620007370 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 196620007371 Mucin-like glycoprotein; Region: Mucin; pfam01456 196620007372 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 196620007373 Fibronectin binding repeat; Region: Fn_bind; pfam02986 196620007374 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 196620007375 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 196620007376 Fibronectin binding repeat; Region: Fn_bind; pfam02986 196620007377 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 196620007378 GntP family permease; Region: GntP_permease; pfam02447 196620007379 fructuronate transporter; Provisional; Region: PRK10034; cl15264 196620007380 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 196620007381 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 196620007382 N- and C-terminal domain interface [polypeptide binding]; other site 196620007383 active site 196620007384 catalytic site [active] 196620007385 metal binding site [ion binding]; metal-binding site 196620007386 carbohydrate binding site [chemical binding]; other site 196620007387 ATP binding site [chemical binding]; other site 196620007388 Transcriptional regulators [Transcription]; Region: GntR; COG1802 196620007389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196620007390 DNA-binding site [nucleotide binding]; DNA binding site 196620007391 FCD domain; Region: FCD; pfam07729 196620007392 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 196620007393 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 196620007394 DNA binding residues [nucleotide binding] 196620007395 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 196620007396 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 196620007397 synthetase active site [active] 196620007398 NTP binding site [chemical binding]; other site 196620007399 metal binding site [ion binding]; metal-binding site 196620007400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 196620007401 Predicted membrane protein [Function unknown]; Region: COG1289 196620007402 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 196620007403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196620007404 D-galactonate transporter; Region: 2A0114; TIGR00893 196620007405 putative substrate translocation pore; other site 196620007406 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 196620007407 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 196620007408 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 196620007409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196620007410 Walker A/P-loop; other site 196620007411 ATP binding site [chemical binding]; other site 196620007412 Q-loop/lid; other site 196620007413 ABC transporter signature motif; other site 196620007414 Walker B; other site 196620007415 D-loop; other site 196620007416 H-loop/switch region; other site 196620007417 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 196620007418 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 196620007419 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 196620007420 similar to hypothetical protein 196620007421 Uncharacterized membrane protein [Function unknown]; Region: COG3949 196620007422 Predicted esterase [General function prediction only]; Region: COG0400 196620007423 putative hydrolase; Provisional; Region: PRK11460 196620007424 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 196620007425 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 196620007426 Zn binding site [ion binding]; other site 196620007427 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 196620007428 Zn binding site [ion binding]; other site 196620007429 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 196620007430 MarR family; Region: MarR; pfam01047 196620007431 Predicted acetyltransferase [General function prediction only]; Region: COG2388 196620007432 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 196620007433 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 196620007434 putative metal binding site [ion binding]; other site 196620007435 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 196620007436 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 196620007437 dimer interface [polypeptide binding]; other site 196620007438 FMN binding site [chemical binding]; other site 196620007439 D-lactate dehydrogenase; Provisional; Region: PRK12480 196620007440 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 196620007441 homodimer interface [polypeptide binding]; other site 196620007442 ligand binding site [chemical binding]; other site 196620007443 NAD binding site [chemical binding]; other site 196620007444 catalytic site [active] 196620007445 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 196620007446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196620007447 active site 196620007448 motif I; other site 196620007449 motif II; other site 196620007450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196620007451 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 196620007452 Walker A/P-loop; other site 196620007453 ATP binding site [chemical binding]; other site 196620007454 Q-loop/lid; other site 196620007455 ABC transporter signature motif; other site 196620007456 Walker B; other site 196620007457 D-loop; other site 196620007458 H-loop/switch region; other site 196620007459 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 196620007460 active site 196620007461 catalytic site [active] 196620007462 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 196620007463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620007464 Coenzyme A binding pocket [chemical binding]; other site 196620007465 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 196620007466 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 196620007467 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 196620007468 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 196620007469 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 196620007470 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 196620007471 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 196620007472 EamA-like transporter family; Region: EamA; pfam00892 196620007473 EamA-like transporter family; Region: EamA; pfam00892 196620007474 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 196620007475 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 196620007476 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 196620007477 catalytic residues [active] 196620007478 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 196620007479 active site 196620007480 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 196620007481 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 196620007482 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 196620007483 active site turn [active] 196620007484 phosphorylation site [posttranslational modification] 196620007485 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 196620007486 HPr interaction site; other site 196620007487 glycerol kinase (GK) interaction site [polypeptide binding]; other site 196620007488 active site 196620007489 phosphorylation site [posttranslational modification] 196620007490 pyruvate oxidase; Provisional; Region: PRK08611 196620007491 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 196620007492 PYR/PP interface [polypeptide binding]; other site 196620007493 tetramer interface [polypeptide binding]; other site 196620007494 dimer interface [polypeptide binding]; other site 196620007495 TPP binding site [chemical binding]; other site 196620007496 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 196620007497 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 196620007498 TPP-binding site [chemical binding]; other site 196620007499 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 196620007500 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 196620007501 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196620007502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196620007503 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 196620007504 putative dimerization interface [polypeptide binding]; other site 196620007505 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 196620007506 Surface antigen [General function prediction only]; Region: COG3942 196620007507 CHAP domain; Region: CHAP; pfam05257 196620007508 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 196620007509 homodimer interface [polypeptide binding]; other site 196620007510 catalytic residues [active] 196620007511 NAD binding site [chemical binding]; other site 196620007512 substrate binding pocket [chemical binding]; other site 196620007513 flexible flap; other site 196620007514 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 196620007515 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 196620007516 dimer interface [polypeptide binding]; other site 196620007517 active site 196620007518 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 196620007519 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 196620007520 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 196620007521 DNA binding site [nucleotide binding] 196620007522 active site 196620007523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620007524 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 196620007525 Walker A motif; other site 196620007526 ATP binding site [chemical binding]; other site 196620007527 Walker B motif; other site 196620007528 arginine finger; other site 196620007529 UvrB/uvrC motif; Region: UVR; pfam02151 196620007530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196620007531 Walker A motif; other site 196620007532 ATP binding site [chemical binding]; other site 196620007533 Walker B motif; other site 196620007534 arginine finger; other site 196620007535 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 196620007536 Virus attachment protein p12 family; Region: P12; pfam12669 196620007537 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 196620007538 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 196620007539 G1 box; other site 196620007540 GTP/Mg2+ binding site [chemical binding]; other site 196620007541 Switch I region; other site 196620007542 G2 box; other site 196620007543 G3 box; other site 196620007544 Switch II region; other site 196620007545 G4 box; other site 196620007546 G5 box; other site 196620007547 Nucleoside recognition; Region: Gate; pfam07670 196620007548 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 196620007549 Nucleoside recognition; Region: Gate; pfam07670 196620007550 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 196620007551 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 196620007552 Protein export membrane protein; Region: SecD_SecF; cl14618 196620007553 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 196620007554 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196620007555 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 196620007556 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 196620007557 Glutamate binding site [chemical binding]; other site 196620007558 homodimer interface [polypeptide binding]; other site 196620007559 NAD binding site [chemical binding]; other site 196620007560 catalytic residues [active] 196620007561 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 196620007562 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 196620007563 active site 196620007564 substrate binding site [chemical binding]; other site 196620007565 trimer interface [polypeptide binding]; other site 196620007566 CoA binding site [chemical binding]; other site 196620007567 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 196620007568 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 196620007569 metal-binding site [ion binding] 196620007570 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 196620007571 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 196620007572 metal-binding site [ion binding] 196620007573 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196620007574 Soluble P-type ATPase [General function prediction only]; Region: COG4087 196620007575 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 196620007576 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 196620007577 metal-binding site [ion binding] 196620007578 D-lactate dehydrogenase; Validated; Region: PRK08605 196620007579 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 196620007580 homodimer interface [polypeptide binding]; other site 196620007581 ligand binding site [chemical binding]; other site 196620007582 NAD binding site [chemical binding]; other site 196620007583 catalytic site [active] 196620007584 transaminase; Reviewed; Region: PRK08068 196620007585 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196620007586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620007587 homodimer interface [polypeptide binding]; other site 196620007588 catalytic residue [active] 196620007589 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 196620007590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 196620007591 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 196620007592 active site lid residues [active] 196620007593 substrate binding pocket [chemical binding]; other site 196620007594 catalytic residues [active] 196620007595 substrate-Mg2+ binding site; other site 196620007596 aspartate-rich region 1; other site 196620007597 aspartate-rich region 2; other site 196620007598 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 196620007599 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 196620007600 active site 196620007601 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 196620007602 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 196620007603 Surface antigen [General function prediction only]; Region: COG3942 196620007604 CHAP domain; Region: CHAP; pfam05257 196620007605 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 196620007606 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 196620007607 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 196620007608 catalytic triad [active] 196620007609 catalytic triad [active] 196620007610 oxyanion hole [active] 196620007611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620007612 Coenzyme A binding pocket [chemical binding]; other site 196620007613 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 196620007614 N-acetyl-D-glucosamine binding site [chemical binding]; other site 196620007615 catalytic residue [active] 196620007616 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 196620007617 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 196620007618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196620007619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196620007620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 196620007621 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 196620007622 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 196620007623 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 196620007624 NmrA-like family; Region: NmrA; pfam05368 196620007625 NADP binding site [chemical binding]; other site 196620007626 active site 196620007627 regulatory binding site [polypeptide binding]; other site 196620007628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 196620007629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196620007630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196620007631 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 196620007632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196620007633 NAD(P) binding site [chemical binding]; other site 196620007634 active site 196620007635 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 196620007636 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 196620007637 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 196620007638 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 196620007639 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 196620007640 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 196620007641 Nucleoside recognition; Region: Gate; pfam07670 196620007642 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 196620007643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 196620007644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 196620007645 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 196620007646 Phosphotransferase enzyme family; Region: APH; pfam01636 196620007647 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 196620007648 active site 196620007649 ATP binding site [chemical binding]; other site 196620007650 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 196620007651 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 196620007652 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 196620007653 quinone interaction residues [chemical binding]; other site 196620007654 active site 196620007655 catalytic residues [active] 196620007656 FMN binding site [chemical binding]; other site 196620007657 substrate binding site [chemical binding]; other site 196620007658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 196620007659 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 196620007660 dimer interface [polypeptide binding]; other site 196620007661 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 196620007662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196620007663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196620007664 Predicted acyl esterases [General function prediction only]; Region: COG2936 196620007665 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 196620007666 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 196620007667 tetramerization interface [polypeptide binding]; other site 196620007668 active site 196620007669 pantoate--beta-alanine ligase; Region: panC; TIGR00018 196620007670 Pantoate-beta-alanine ligase; Region: PanC; cd00560 196620007671 active site 196620007672 ATP-binding site [chemical binding]; other site 196620007673 pantoate-binding site; other site 196620007674 HXXH motif; other site 196620007675 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 196620007676 oligomerization interface [polypeptide binding]; other site 196620007677 active site 196620007678 metal binding site [ion binding]; metal-binding site 196620007679 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 196620007680 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 196620007681 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 196620007682 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 196620007683 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 196620007684 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 196620007685 tetramer (dimer of dimers) interface [polypeptide binding]; other site 196620007686 NAD binding site [chemical binding]; other site 196620007687 dimer interface [polypeptide binding]; other site 196620007688 substrate binding site [chemical binding]; other site 196620007689 amino acid transporter; Region: 2A0306; TIGR00909 196620007690 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 196620007691 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196620007692 inhibitor-cofactor binding pocket; inhibition site 196620007693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620007694 catalytic residue [active] 196620007695 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 196620007696 catalytic residue [active] 196620007697 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 196620007698 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 196620007699 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 196620007700 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 196620007701 acyl-activating enzyme (AAE) consensus motif; other site 196620007702 AMP binding site [chemical binding]; other site 196620007703 active site 196620007704 CoA binding site [chemical binding]; other site 196620007705 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 196620007706 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 196620007707 choline dehydrogenase; Validated; Region: PRK02106 196620007708 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 196620007709 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 196620007710 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 196620007711 tetramerization interface [polypeptide binding]; other site 196620007712 NAD(P) binding site [chemical binding]; other site 196620007713 catalytic residues [active] 196620007714 Predicted transcriptional regulators [Transcription]; Region: COG1510 196620007715 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 196620007716 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 196620007717 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 196620007718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196620007719 FeS/SAM binding site; other site 196620007720 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 196620007721 Class III ribonucleotide reductase; Region: RNR_III; cd01675 196620007722 effector binding site; other site 196620007723 active site 196620007724 Zn binding site [ion binding]; other site 196620007725 glycine loop; other site 196620007726 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 196620007727 Citrate transporter; Region: CitMHS; pfam03600 196620007728 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 196620007729 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 196620007730 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 196620007731 Flavodoxin; Region: Flavodoxin_1; pfam00258 196620007732 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 196620007733 FAD binding pocket [chemical binding]; other site 196620007734 FAD binding motif [chemical binding]; other site 196620007735 catalytic residues [active] 196620007736 NAD binding pocket [chemical binding]; other site 196620007737 phosphate binding motif [ion binding]; other site 196620007738 beta-alpha-beta structure motif; other site 196620007739 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 196620007740 catalytic residues [active] 196620007741 dimer interface [polypeptide binding]; other site 196620007742 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 196620007743 FtsX-like permease family; Region: FtsX; pfam02687 196620007744 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196620007745 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 196620007746 Walker A/P-loop; other site 196620007747 ATP binding site [chemical binding]; other site 196620007748 Q-loop/lid; other site 196620007749 ABC transporter signature motif; other site 196620007750 Walker B; other site 196620007751 D-loop; other site 196620007752 H-loop/switch region; other site 196620007753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 196620007754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196620007755 ATP binding site [chemical binding]; other site 196620007756 Mg2+ binding site [ion binding]; other site 196620007757 G-X-G motif; other site 196620007758 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196620007759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196620007760 active site 196620007761 phosphorylation site [posttranslational modification] 196620007762 intermolecular recognition site; other site 196620007763 dimerization interface [polypeptide binding]; other site 196620007764 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196620007765 DNA binding site [nucleotide binding] 196620007766 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 196620007767 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 196620007768 dimer interface [polypeptide binding]; other site 196620007769 active site 196620007770 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 196620007771 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 196620007772 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 196620007773 MarR family; Region: MarR_2; pfam12802 196620007774 Predicted esterase [General function prediction only]; Region: COG0627 196620007775 S-formylglutathione hydrolase; Region: PLN02442 196620007776 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 196620007777 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 196620007778 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 196620007779 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 196620007780 ligand binding site [chemical binding]; other site 196620007781 flexible hinge region; other site 196620007782 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 196620007783 carbamate kinase; Reviewed; Region: PRK12686 196620007784 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 196620007785 putative substrate binding site [chemical binding]; other site 196620007786 nucleotide binding site [chemical binding]; other site 196620007787 nucleotide binding site [chemical binding]; other site 196620007788 homodimer interface [polypeptide binding]; other site 196620007789 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 196620007790 ornithine carbamoyltransferase; Validated; Region: PRK02102 196620007791 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 196620007792 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 196620007793 arginine deiminase; Provisional; Region: PRK01388 196620007794 Arginine repressor [Transcription]; Region: ArgR; COG1438 196620007795 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 196620007796 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 196620007797 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 196620007798 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 196620007799 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 196620007800 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 196620007801 active site 196620007802 Zn binding site [ion binding]; other site 196620007803 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 196620007804 HTH domain; Region: HTH_11; pfam08279 196620007805 PRD domain; Region: PRD; pfam00874 196620007806 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 196620007807 active site 196620007808 P-loop; other site 196620007809 phosphorylation site [posttranslational modification] 196620007810 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 196620007811 active site 196620007812 phosphorylation site [posttranslational modification] 196620007813 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 196620007814 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 196620007815 active site 196620007816 P-loop; other site 196620007817 phosphorylation site [posttranslational modification] 196620007818 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 196620007819 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 196620007820 active site 196620007821 phosphorylation site [posttranslational modification] 196620007822 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 196620007823 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 196620007824 Predicted membrane protein [Function unknown]; Region: COG1511 196620007825 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 196620007826 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 196620007827 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 196620007828 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 196620007829 CHAP domain; Region: CHAP; pfam05257 196620007830 Isochorismatase family; Region: Isochorismatase; pfam00857 196620007831 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 196620007832 catalytic triad [active] 196620007833 conserved cis-peptide bond; other site 196620007834 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 196620007835 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 196620007836 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 196620007837 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 196620007838 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 196620007839 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 196620007840 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 196620007841 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 196620007842 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 196620007843 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 196620007844 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 196620007845 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 196620007846 SecY translocase; Region: SecY; pfam00344 196620007847 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 196620007848 legume lectins; Region: lectin_L-type; cd01951 196620007849 homotetramer interaction site [polypeptide binding]; other site 196620007850 carbohydrate binding site [chemical binding]; other site 196620007851 metal binding site [ion binding]; metal-binding site 196620007852 Putative Ig domain; Region: He_PIG; pfam05345 196620007853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 196620007854 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 196620007855 methionine sulfoxide reductase A; Provisional; Region: PRK05528 196620007856 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 196620007857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196620007858 Coenzyme A binding pocket [chemical binding]; other site 196620007859 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 196620007860 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 196620007861 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 196620007862 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 196620007863 Chain length determinant protein; Region: Wzz; cl15801 196620007864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196620007865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196620007866 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 196620007867 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 196620007868 DXD motif; other site 196620007869 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 196620007870 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 196620007871 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 196620007872 Acyltransferase family; Region: Acyl_transf_3; pfam01757 196620007873 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 196620007874 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 196620007875 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 196620007876 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 196620007877 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 196620007878 metal binding site [ion binding]; metal-binding site 196620007879 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 196620007880 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 196620007881 substrate binding site [chemical binding]; other site 196620007882 glutamase interaction surface [polypeptide binding]; other site 196620007883 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 196620007884 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 196620007885 catalytic residues [active] 196620007886 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 196620007887 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 196620007888 putative active site [active] 196620007889 oxyanion strand; other site 196620007890 catalytic triad [active] 196620007891 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 196620007892 putative active site pocket [active] 196620007893 4-fold oligomerization interface [polypeptide binding]; other site 196620007894 metal binding residues [ion binding]; metal-binding site 196620007895 3-fold/trimer interface [polypeptide binding]; other site 196620007896 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 196620007897 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196620007898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196620007899 homodimer interface [polypeptide binding]; other site 196620007900 catalytic residue [active] 196620007901 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 196620007902 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 196620007903 NAD binding site [chemical binding]; other site 196620007904 dimerization interface [polypeptide binding]; other site 196620007905 product binding site; other site 196620007906 substrate binding site [chemical binding]; other site 196620007907 zinc binding site [ion binding]; other site 196620007908 catalytic residues [active] 196620007909 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 196620007910 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 196620007911 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 196620007912 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 196620007913 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 196620007914 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 196620007915 putative active site [active] 196620007916 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 196620007917 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 196620007918 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 196620007919 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 196620007920 Walker A/P-loop; other site 196620007921 ATP binding site [chemical binding]; other site 196620007922 Q-loop/lid; other site 196620007923 ABC transporter signature motif; other site 196620007924 Walker B; other site 196620007925 D-loop; other site 196620007926 H-loop/switch region; other site 196620007927 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 196620007928 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 196620007929 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 196620007930 Walker A/P-loop; other site 196620007931 ATP binding site [chemical binding]; other site 196620007932 Q-loop/lid; other site 196620007933 ABC transporter signature motif; other site 196620007934 Walker B; other site 196620007935 D-loop; other site 196620007936 H-loop/switch region; other site 196620007937 hypothetical protein; Provisional; Region: PRK13661 196620007938 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 196620007939 Uncharacterized conserved protein [Function unknown]; Region: COG1912 196620007940 Uncharacterized conserved protein [Function unknown]; Region: COG2353 196620007941 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 196620007942 Strictosidine synthase; Region: Str_synth; pfam03088 196620007943 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 196620007944 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 196620007945 active site residue [active] 196620007946 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 196620007947 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 196620007948 putative substrate binding pocket [chemical binding]; other site 196620007949 AC domain interface; other site 196620007950 catalytic triad [active] 196620007951 AB domain interface; other site 196620007952 interchain disulfide; other site 196620007953 DinB superfamily; Region: DinB_2; pfam12867 196620007954 Collagen binding domain; Region: Collagen_bind; pfam05737 196620007955 Cna protein B-type domain; Region: Cna_B; pfam05738 196620007956 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 196620007957 domain interaction interfaces [polypeptide binding]; other site 196620007958 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 196620007959 domain interaction interfaces [polypeptide binding]; other site 196620007960 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 196620007961 domain interaction interfaces [polypeptide binding]; other site 196620007962 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 196620007963 domain interaction interfaces [polypeptide binding]; other site 196620007964 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 196620007965 domain interaction interfaces [polypeptide binding]; other site 196620007966 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 196620007967 domain interaction interfaces [polypeptide binding]; other site 196620007968 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 196620007969 domain interaction interfaces [polypeptide binding]; other site 196620007970 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 196620007971 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 196620007972 transmembrane helices; other site 196620007973 similar to hypothetical protein 196620007974 Predicted permeases [General function prediction only]; Region: RarD; COG2962 196620007975 EamA-like transporter family; Region: EamA; pfam00892 196620007976 hypothetical protein; Provisional; Region: PRK07758 196620007977 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 196620007978 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 196620007979 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 196620007980 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196620007981 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 196620007982 Walker A/P-loop; other site 196620007983 ATP binding site [chemical binding]; other site 196620007984 Q-loop/lid; other site 196620007985 ABC transporter signature motif; other site 196620007986 Walker B; other site 196620007987 D-loop; other site 196620007988 H-loop/switch region; other site 196620007989 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 196620007990 FtsX-like permease family; Region: FtsX; pfam02687 196620007991 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 196620007992 DNA-binding site [nucleotide binding]; DNA binding site 196620007993 RNA-binding motif; other site 196620007994 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196620007995 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196620007996 non-specific DNA binding site [nucleotide binding]; other site 196620007997 salt bridge; other site 196620007998 sequence-specific DNA binding site [nucleotide binding]; other site 196620007999 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 196620008000 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 196620008001 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 196620008002 ParB-like nuclease domain; Region: ParBc; pfam02195 196620008003 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 196620008004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196620008005 S-adenosylmethionine binding site [chemical binding]; other site 196620008006 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 196620008007 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 196620008008 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 196620008009 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 196620008010 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 196620008011 trmE is a tRNA modification GTPase; Region: trmE; cd04164 196620008012 G1 box; other site 196620008013 GTP/Mg2+ binding site [chemical binding]; other site 196620008014 Switch I region; other site 196620008015 G2 box; other site 196620008016 Switch II region; other site 196620008017 G3 box; other site 196620008018 G4 box; other site 196620008019 G5 box; other site 196620008020 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 196620008021 ribonuclease P; Reviewed; Region: rnpA; PRK00499 196620008022 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399