-- dump date 20140620_074357 -- class Genbank::misc_feature -- table misc_feature_note -- id note 418127000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 418127000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 418127000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127000004 Walker A motif; other site 418127000005 ATP binding site [chemical binding]; other site 418127000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 418127000007 Walker B motif; other site 418127000008 arginine finger; other site 418127000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 418127000010 DnaA box-binding interface [nucleotide binding]; other site 418127000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 418127000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 418127000013 putative DNA binding surface [nucleotide binding]; other site 418127000014 dimer interface [polypeptide binding]; other site 418127000015 beta-clamp/clamp loader binding surface; other site 418127000016 beta-clamp/translesion DNA polymerase binding surface; other site 418127000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 418127000018 recF protein; Region: recf; TIGR00611 418127000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 418127000020 Walker A/P-loop; other site 418127000021 ATP binding site [chemical binding]; other site 418127000022 Q-loop/lid; other site 418127000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 418127000024 ABC transporter signature motif; other site 418127000025 Walker B; other site 418127000026 D-loop; other site 418127000027 H-loop/switch region; other site 418127000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 418127000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127000030 Mg2+ binding site [ion binding]; other site 418127000031 G-X-G motif; other site 418127000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 418127000033 anchoring element; other site 418127000034 dimer interface [polypeptide binding]; other site 418127000035 ATP binding site [chemical binding]; other site 418127000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 418127000037 active site 418127000038 putative metal-binding site [ion binding]; other site 418127000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 418127000040 DNA gyrase subunit A; Validated; Region: PRK05560 418127000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 418127000042 CAP-like domain; other site 418127000043 active site 418127000044 primary dimer interface [polypeptide binding]; other site 418127000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 418127000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 418127000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 418127000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 418127000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 418127000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 418127000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 418127000052 putative substrate binding site [chemical binding]; other site 418127000053 putative ATP binding site [chemical binding]; other site 418127000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 418127000055 active sites [active] 418127000056 tetramer interface [polypeptide binding]; other site 418127000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 418127000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 418127000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 418127000060 dimer interface [polypeptide binding]; other site 418127000061 active site 418127000062 motif 1; other site 418127000063 motif 2; other site 418127000064 motif 3; other site 418127000065 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 418127000066 Predicted membrane protein [Function unknown]; Region: COG4392 418127000067 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 418127000068 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 418127000069 Predicted membrane protein [Function unknown]; Region: COG4241 418127000070 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 418127000071 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 418127000072 DHH family; Region: DHH; pfam01368 418127000073 DHHA1 domain; Region: DHHA1; pfam02272 418127000074 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 418127000075 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 418127000076 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 418127000077 replicative DNA helicase; Region: DnaB; TIGR00665 418127000078 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 418127000079 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 418127000080 Walker A motif; other site 418127000081 ATP binding site [chemical binding]; other site 418127000082 Walker B motif; other site 418127000083 DNA binding loops [nucleotide binding] 418127000084 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 418127000085 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 418127000086 GDP-binding site [chemical binding]; other site 418127000087 ACT binding site; other site 418127000088 IMP binding site; other site 418127000089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127000090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127000091 active site 418127000092 phosphorylation site [posttranslational modification] 418127000093 intermolecular recognition site; other site 418127000094 dimerization interface [polypeptide binding]; other site 418127000095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 418127000096 DNA binding site [nucleotide binding] 418127000097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 418127000098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 418127000099 dimerization interface [polypeptide binding]; other site 418127000100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 418127000101 putative active site [active] 418127000102 heme pocket [chemical binding]; other site 418127000103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 418127000104 dimer interface [polypeptide binding]; other site 418127000105 phosphorylation site [posttranslational modification] 418127000106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127000107 ATP binding site [chemical binding]; other site 418127000108 Mg2+ binding site [ion binding]; other site 418127000109 G-X-G motif; other site 418127000110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 418127000111 YycH protein; Region: YycH; pfam07435 418127000112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 418127000113 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 418127000114 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 418127000115 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 418127000116 putative active site [active] 418127000117 putative metal binding site [ion binding]; other site 418127000118 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 418127000119 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 418127000120 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 418127000121 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 418127000122 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 418127000123 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 418127000124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 418127000125 Integrase core domain; Region: rve; pfam00665 418127000126 Replication protein; Region: Rep_1; cl02412 418127000127 Plasmid rolling circle replication initiator protein and truncated derivatives [DNA replication, recombination, and repair]; Region: COG5655 418127000128 similar to hypothetical protein 418127000129 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 418127000130 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 418127000131 dimer interface [polypeptide binding]; other site 418127000132 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 418127000133 ligand binding site [chemical binding]; other site 418127000134 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cd05397 418127000135 metal binding triad [ion binding]; metal-binding site 418127000136 KNTase C-terminal domain; Region: KNTase_C; pfam07827 418127000137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 418127000138 Integrase core domain; Region: rve; pfam00665 418127000139 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 418127000140 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 418127000141 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 418127000142 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 418127000143 putative active site [active] 418127000144 catalytic site [active] 418127000145 putative metal binding site [ion binding]; other site 418127000146 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 418127000147 putative active site [active] 418127000148 putative catalytic site [active] 418127000149 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 418127000150 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 418127000151 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 418127000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 418127000153 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 418127000154 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 418127000155 Predicted transcriptional regulator [Transcription]; Region: COG3682 418127000156 MarR family; Region: MarR_2; pfam12802 418127000157 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 418127000158 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 418127000159 nucleotide binding site [chemical binding]; other site 418127000160 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 418127000161 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 418127000162 active site residue [active] 418127000163 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 418127000164 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 418127000165 active site residue [active] 418127000166 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 418127000167 CPxP motif; other site 418127000168 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 418127000169 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 418127000170 putative homodimer interface [polypeptide binding]; other site 418127000171 putative homotetramer interface [polypeptide binding]; other site 418127000172 putative metal binding site [ion binding]; other site 418127000173 putative homodimer-homodimer interface [polypeptide binding]; other site 418127000174 putative allosteric switch controlling residues; other site 418127000175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127000176 S-adenosylmethionine binding site [chemical binding]; other site 418127000177 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 418127000178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127000179 S-adenosylmethionine binding site [chemical binding]; other site 418127000180 aminoglycoside resistance protein; Provisional; Region: PRK13746 418127000181 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 418127000182 active site 418127000183 NTP binding site [chemical binding]; other site 418127000184 metal binding triad [ion binding]; metal-binding site 418127000185 antibiotic binding site [chemical binding]; other site 418127000186 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 418127000187 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 418127000188 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 418127000189 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 418127000190 Int/Topo IB signature motif; other site 418127000191 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 418127000192 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 418127000193 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 418127000194 Int/Topo IB signature motif; other site 418127000195 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 418127000196 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 418127000197 MPN+ (JAMM) motif; other site 418127000198 Zinc-binding site [ion binding]; other site 418127000199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4333 418127000200 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 418127000201 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 418127000202 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 418127000203 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 418127000204 catalytic residues [active] 418127000205 catalytic nucleophile [active] 418127000206 Presynaptic Site I dimer interface [polypeptide binding]; other site 418127000207 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 418127000208 Synaptic Flat tetramer interface [polypeptide binding]; other site 418127000209 Synaptic Site I dimer interface [polypeptide binding]; other site 418127000210 DNA binding site [nucleotide binding] 418127000211 Recombinase; Region: Recombinase; pfam07508 418127000212 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 418127000213 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 418127000214 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 418127000215 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 418127000216 catalytic residues [active] 418127000217 catalytic nucleophile [active] 418127000218 Recombinase; Region: Recombinase; pfam07508 418127000219 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 418127000220 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 418127000221 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 418127000222 Integrase core domain; Region: rve; pfam00665 418127000223 Integrase core domain; Region: rve_3; cl15866 418127000224 HTH-like domain; Region: HTH_21; pfam13276 418127000225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 418127000226 Homeodomain-like domain; Region: HTH_23; cl17451 418127000227 Predicted membrane protein [Function unknown]; Region: COG1288 418127000228 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127000229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127000230 active site 418127000231 phosphorylation site [posttranslational modification] 418127000232 intermolecular recognition site; other site 418127000233 dimerization interface [polypeptide binding]; other site 418127000234 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 418127000235 DNA binding site [nucleotide binding] 418127000236 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 418127000237 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 418127000238 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 418127000239 Ligand Binding Site [chemical binding]; other site 418127000240 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 418127000241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 418127000242 dimer interface [polypeptide binding]; other site 418127000243 phosphorylation site [posttranslational modification] 418127000244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127000245 ATP binding site [chemical binding]; other site 418127000246 Mg2+ binding site [ion binding]; other site 418127000247 G-X-G motif; other site 418127000248 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 418127000249 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 418127000250 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 418127000251 Soluble P-type ATPase [General function prediction only]; Region: COG4087 418127000252 potassium-transporting ATPase subunit C; Provisional; Region: PRK14000 418127000253 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 418127000254 Protein kinase domain; Region: Pkinase; pfam00069 418127000255 Catalytic domain of Protein Kinases; Region: PKc; cd00180 418127000256 active site 418127000257 ATP binding site [chemical binding]; other site 418127000258 substrate binding site [chemical binding]; other site 418127000259 activation loop (A-loop); other site 418127000260 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 418127000261 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 418127000262 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 418127000263 phosphate binding site [ion binding]; other site 418127000264 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 418127000265 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 418127000266 putative homodimer interface [polypeptide binding]; other site 418127000267 putative homotetramer interface [polypeptide binding]; other site 418127000268 putative metal binding site [ion binding]; other site 418127000269 putative homodimer-homodimer interface [polypeptide binding]; other site 418127000270 putative allosteric switch controlling residues; other site 418127000271 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 418127000272 active site residue [active] 418127000273 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 418127000274 CPxP motif; other site 418127000275 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 418127000276 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 418127000277 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 418127000278 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 418127000279 active site residue [active] 418127000280 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 418127000281 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 418127000282 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 418127000283 FMN binding site [chemical binding]; other site 418127000284 active site 418127000285 catalytic residues [active] 418127000286 substrate binding site [chemical binding]; other site 418127000287 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 418127000288 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 418127000289 Part of AAA domain; Region: AAA_19; pfam13245 418127000290 AAA domain; Region: AAA_12; pfam13087 418127000291 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 418127000292 active site 418127000293 catalytic site [active] 418127000294 putative metal binding site [ion binding]; other site 418127000295 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127000296 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127000297 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127000298 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127000299 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127000300 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 418127000301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 418127000302 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 418127000303 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 418127000304 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 418127000305 metal binding site [ion binding]; metal-binding site 418127000306 dimer interface [polypeptide binding]; other site 418127000307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000308 Major Facilitator Superfamily; Region: MFS_1; pfam07690 418127000309 putative substrate translocation pore; other site 418127000310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000311 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 418127000312 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 418127000313 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 418127000314 PhoU domain; Region: PhoU; pfam01895 418127000315 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 418127000316 EamA-like transporter family; Region: EamA; pfam00892 418127000317 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 418127000318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 418127000319 DNA-binding site [nucleotide binding]; DNA binding site 418127000320 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 418127000321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127000322 homodimer interface [polypeptide binding]; other site 418127000323 catalytic residue [active] 418127000324 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 418127000325 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 418127000326 L-lactate permease; Region: Lactate_perm; cl00701 418127000327 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 418127000328 B domain; Region: B; pfam02216 418127000329 B domain; Region: B; pfam02216 418127000330 B domain; Region: B; pfam02216 418127000331 B domain; Region: B; pfam02216 418127000332 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 418127000333 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 418127000334 Transcriptional regulators [Transcription]; Region: MarR; COG1846 418127000335 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 418127000336 Transcriptional regulators [Transcription]; Region: MarR; COG1846 418127000337 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 418127000338 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 418127000339 ABC-ATPase subunit interface; other site 418127000340 dimer interface [polypeptide binding]; other site 418127000341 putative PBP binding regions; other site 418127000342 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 418127000343 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 418127000344 ABC-ATPase subunit interface; other site 418127000345 dimer interface [polypeptide binding]; other site 418127000346 putative PBP binding regions; other site 418127000347 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 418127000348 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 418127000349 siderophore binding site; other site 418127000350 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 418127000351 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 418127000352 dimer interface [polypeptide binding]; other site 418127000353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127000354 catalytic residue [active] 418127000355 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 418127000356 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 418127000357 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 418127000358 IucA / IucC family; Region: IucA_IucC; pfam04183 418127000359 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 418127000360 drug efflux system protein MdtG; Provisional; Region: PRK09874 418127000361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000362 putative substrate translocation pore; other site 418127000363 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 418127000364 IucA / IucC family; Region: IucA_IucC; pfam04183 418127000365 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 418127000366 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 418127000367 IucA / IucC family; Region: IucA_IucC; pfam04183 418127000368 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 418127000369 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 418127000370 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 418127000371 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 418127000372 dimer interface [polypeptide binding]; other site 418127000373 active site 418127000374 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 418127000375 catalytic residues [active] 418127000376 substrate binding site [chemical binding]; other site 418127000377 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 418127000378 ParB-like nuclease domain; Region: ParBc; pfam02195 418127000379 acetoin reductase; Validated; Region: PRK08643 418127000380 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 418127000381 NAD binding site [chemical binding]; other site 418127000382 homotetramer interface [polypeptide binding]; other site 418127000383 homodimer interface [polypeptide binding]; other site 418127000384 active site 418127000385 substrate binding site [chemical binding]; other site 418127000386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127000387 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 418127000388 NAD(P) binding site [chemical binding]; other site 418127000389 active site 418127000390 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 418127000391 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 418127000392 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 418127000393 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 418127000394 putative ADP-binding pocket [chemical binding]; other site 418127000395 O-Antigen Polymerase; Region: Wzy_C; cl04850 418127000396 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 418127000397 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 418127000398 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 418127000399 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 418127000400 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 418127000401 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 418127000402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 418127000403 DNA-binding site [nucleotide binding]; DNA binding site 418127000404 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 418127000405 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 418127000406 Major Facilitator Superfamily; Region: MFS_1; pfam07690 418127000407 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 418127000408 intersubunit interface [polypeptide binding]; other site 418127000409 active site 418127000410 catalytic residue [active] 418127000411 phosphopentomutase; Provisional; Region: PRK05362 418127000412 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 418127000413 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 418127000414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127000415 dimer interface [polypeptide binding]; other site 418127000416 conserved gate region; other site 418127000417 putative PBP binding loops; other site 418127000418 ABC-ATPase subunit interface; other site 418127000419 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 418127000420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127000421 dimer interface [polypeptide binding]; other site 418127000422 conserved gate region; other site 418127000423 ABC-ATPase subunit interface; other site 418127000424 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 418127000425 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 418127000426 Walker A/P-loop; other site 418127000427 ATP binding site [chemical binding]; other site 418127000428 Q-loop/lid; other site 418127000429 ABC transporter signature motif; other site 418127000430 Walker B; other site 418127000431 D-loop; other site 418127000432 H-loop/switch region; other site 418127000433 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 418127000434 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 418127000435 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 418127000436 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 418127000437 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 418127000438 active site 418127000439 metal binding site [ion binding]; metal-binding site 418127000440 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 418127000441 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 418127000442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127000443 non-specific DNA binding site [nucleotide binding]; other site 418127000444 salt bridge; other site 418127000445 sequence-specific DNA binding site [nucleotide binding]; other site 418127000446 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 418127000447 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 418127000448 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 418127000449 putative catalytic cysteine [active] 418127000450 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 418127000451 putative active site [active] 418127000452 metal binding site [ion binding]; metal-binding site 418127000453 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 418127000454 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 418127000455 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 418127000456 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 418127000457 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 418127000458 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 418127000459 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 418127000460 NAD(P) binding site [chemical binding]; other site 418127000461 homodimer interface [polypeptide binding]; other site 418127000462 substrate binding site [chemical binding]; other site 418127000463 active site 418127000464 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 418127000465 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 418127000466 NAD(P) binding site [chemical binding]; other site 418127000467 homodimer interface [polypeptide binding]; other site 418127000468 substrate binding site [chemical binding]; other site 418127000469 active site 418127000470 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 418127000471 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 418127000472 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 418127000473 putative NAD(P) binding site [chemical binding]; other site 418127000474 active site 418127000475 putative substrate binding site [chemical binding]; other site 418127000476 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 418127000477 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 418127000478 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 418127000479 active site 418127000480 homodimer interface [polypeptide binding]; other site 418127000481 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 418127000482 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 418127000483 trimer interface [polypeptide binding]; other site 418127000484 active site 418127000485 substrate binding site [chemical binding]; other site 418127000486 CoA binding site [chemical binding]; other site 418127000487 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 418127000488 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 418127000489 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 418127000490 O-Antigen ligase; Region: Wzy_C; pfam04932 418127000491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 418127000492 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 418127000493 Bacterial sugar transferase; Region: Bac_transf; pfam02397 418127000494 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 418127000495 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 418127000496 putative NAD(P) binding site [chemical binding]; other site 418127000497 active site 418127000498 putative substrate binding site [chemical binding]; other site 418127000499 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 418127000500 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 418127000501 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 418127000502 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 418127000503 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 418127000504 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 418127000505 active site 418127000506 homodimer interface [polypeptide binding]; other site 418127000507 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 418127000508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 418127000509 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 418127000510 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 418127000511 NAD(P) binding site [chemical binding]; other site 418127000512 catalytic residues [active] 418127000513 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 418127000514 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 418127000515 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 418127000516 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 418127000517 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 418127000518 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 418127000519 Walker A/P-loop; other site 418127000520 ATP binding site [chemical binding]; other site 418127000521 Q-loop/lid; other site 418127000522 ABC transporter signature motif; other site 418127000523 Walker B; other site 418127000524 D-loop; other site 418127000525 H-loop/switch region; other site 418127000526 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 418127000527 NMT1-like family; Region: NMT1_2; pfam13379 418127000528 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 418127000529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 418127000530 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 418127000531 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 418127000532 active site 418127000533 Uncharacterized conserved protein [Function unknown]; Region: COG5609 418127000534 formate dehydrogenase; Provisional; Region: PRK07574 418127000535 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 418127000536 dimerization interface [polypeptide binding]; other site 418127000537 ligand binding site [chemical binding]; other site 418127000538 NAD binding site [chemical binding]; other site 418127000539 catalytic site [active] 418127000540 putative transporter; Provisional; Region: PRK10054 418127000541 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 418127000542 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 418127000543 acyl-activating enzyme (AAE) consensus motif; other site 418127000544 AMP binding site [chemical binding]; other site 418127000545 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 418127000546 Condensation domain; Region: Condensation; pfam00668 418127000547 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 418127000548 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 418127000549 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 418127000550 acyl-activating enzyme (AAE) consensus motif; other site 418127000551 AMP binding site [chemical binding]; other site 418127000552 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 418127000553 thioester reductase domain; Region: Thioester-redct; TIGR01746 418127000554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127000555 NAD(P) binding site [chemical binding]; other site 418127000556 active site 418127000557 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 418127000558 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 418127000559 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 418127000560 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 418127000561 nucleotide binding site [chemical binding]; other site 418127000562 N-acetyl-L-glutamate binding site [chemical binding]; other site 418127000563 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 418127000564 heterotetramer interface [polypeptide binding]; other site 418127000565 active site pocket [active] 418127000566 cleavage site 418127000567 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 418127000568 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 418127000569 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 418127000570 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 418127000571 inhibitor-cofactor binding pocket; inhibition site 418127000572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127000573 catalytic residue [active] 418127000574 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 418127000575 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 418127000576 Isochorismatase family; Region: Isochorismatase; pfam00857 418127000577 catalytic triad [active] 418127000578 conserved cis-peptide bond; other site 418127000579 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 418127000580 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 418127000581 dimer interface [polypeptide binding]; other site 418127000582 PYR/PP interface [polypeptide binding]; other site 418127000583 TPP binding site [chemical binding]; other site 418127000584 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 418127000585 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 418127000586 TPP-binding site [chemical binding]; other site 418127000587 dimer interface [polypeptide binding]; other site 418127000588 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 418127000589 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 418127000590 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 418127000591 active site turn [active] 418127000592 phosphorylation site [posttranslational modification] 418127000593 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 418127000594 HPr interaction site; other site 418127000595 glycerol kinase (GK) interaction site [polypeptide binding]; other site 418127000596 active site 418127000597 phosphorylation site [posttranslational modification] 418127000598 Uncharacterized conserved protein [Function unknown]; Region: COG3589 418127000599 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 418127000600 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 418127000601 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 418127000602 putative active site [active] 418127000603 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 418127000604 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 418127000605 active site turn [active] 418127000606 phosphorylation site [posttranslational modification] 418127000607 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 418127000608 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 418127000609 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 418127000610 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 418127000611 putative active site [active] 418127000612 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 418127000613 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 418127000614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127000615 ATP binding site [chemical binding]; other site 418127000616 putative Mg++ binding site [ion binding]; other site 418127000617 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 418127000618 HlyD family secretion protein; Region: HlyD_3; pfam13437 418127000619 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 418127000620 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 418127000621 Walker A/P-loop; other site 418127000622 ATP binding site [chemical binding]; other site 418127000623 Q-loop/lid; other site 418127000624 ABC transporter signature motif; other site 418127000625 Walker B; other site 418127000626 D-loop; other site 418127000627 H-loop/switch region; other site 418127000628 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 418127000629 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 418127000630 FtsX-like permease family; Region: FtsX; pfam02687 418127000631 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 418127000632 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 418127000633 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 418127000634 Walker A/P-loop; other site 418127000635 ATP binding site [chemical binding]; other site 418127000636 Q-loop/lid; other site 418127000637 ABC transporter signature motif; other site 418127000638 Walker B; other site 418127000639 D-loop; other site 418127000640 H-loop/switch region; other site 418127000641 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 418127000642 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 418127000643 Walker A/P-loop; other site 418127000644 ATP binding site [chemical binding]; other site 418127000645 Q-loop/lid; other site 418127000646 ABC transporter signature motif; other site 418127000647 Walker B; other site 418127000648 D-loop; other site 418127000649 H-loop/switch region; other site 418127000650 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 418127000651 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 418127000652 Walker A/P-loop; other site 418127000653 ATP binding site [chemical binding]; other site 418127000654 Q-loop/lid; other site 418127000655 ABC transporter signature motif; other site 418127000656 Walker B; other site 418127000657 D-loop; other site 418127000658 H-loop/switch region; other site 418127000659 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 418127000660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127000661 dimer interface [polypeptide binding]; other site 418127000662 conserved gate region; other site 418127000663 putative PBP binding loops; other site 418127000664 ABC-ATPase subunit interface; other site 418127000665 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 418127000666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127000667 dimer interface [polypeptide binding]; other site 418127000668 conserved gate region; other site 418127000669 ABC-ATPase subunit interface; other site 418127000670 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 418127000671 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 418127000672 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 418127000673 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 418127000674 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 418127000675 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742 418127000676 azoreductase; Reviewed; Region: PRK00170 418127000677 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 418127000678 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 418127000679 Peptidase family M23; Region: Peptidase_M23; pfam01551 418127000680 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 418127000681 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 418127000682 Walker A/P-loop; other site 418127000683 ATP binding site [chemical binding]; other site 418127000684 Q-loop/lid; other site 418127000685 ABC transporter signature motif; other site 418127000686 Walker B; other site 418127000687 D-loop; other site 418127000688 H-loop/switch region; other site 418127000689 TOBE domain; Region: TOBE; pfam03459 418127000690 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 418127000691 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 418127000692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127000693 dimer interface [polypeptide binding]; other site 418127000694 conserved gate region; other site 418127000695 ABC-ATPase subunit interface; other site 418127000696 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 418127000697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127000698 dimer interface [polypeptide binding]; other site 418127000699 conserved gate region; other site 418127000700 putative PBP binding loops; other site 418127000701 ABC-ATPase subunit interface; other site 418127000702 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 418127000703 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 418127000704 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 418127000705 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 418127000706 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 418127000707 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 418127000708 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 418127000709 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 418127000710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 418127000711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000712 putative substrate translocation pore; other site 418127000713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000714 Response regulator receiver domain; Region: Response_reg; pfam00072 418127000715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127000716 active site 418127000717 phosphorylation site [posttranslational modification] 418127000718 intermolecular recognition site; other site 418127000719 dimerization interface [polypeptide binding]; other site 418127000720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 418127000721 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 418127000722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 418127000723 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 418127000724 Histidine kinase; Region: His_kinase; pfam06580 418127000725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127000726 ATP binding site [chemical binding]; other site 418127000727 Mg2+ binding site [ion binding]; other site 418127000728 G-X-G motif; other site 418127000729 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 418127000730 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 418127000731 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 418127000732 Pyruvate formate lyase 1; Region: PFL1; cd01678 418127000733 coenzyme A binding site [chemical binding]; other site 418127000734 active site 418127000735 catalytic residues [active] 418127000736 glycine loop; other site 418127000737 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 418127000738 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 418127000739 FeS/SAM binding site; other site 418127000740 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 418127000741 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 418127000742 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 418127000743 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 418127000744 putative active site [active] 418127000745 catalytic site [active] 418127000746 putative metal binding site [ion binding]; other site 418127000747 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 418127000748 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 418127000749 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 418127000750 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 418127000751 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 418127000752 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 418127000753 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 418127000754 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 418127000755 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 418127000756 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 418127000757 dimer interface [polypeptide binding]; other site 418127000758 active site 418127000759 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 418127000760 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 418127000761 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 418127000762 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 418127000763 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 418127000764 substrate binding site [chemical binding]; other site 418127000765 oxyanion hole (OAH) forming residues; other site 418127000766 trimer interface [polypeptide binding]; other site 418127000767 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 418127000768 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 418127000769 active site 418127000770 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 418127000771 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 418127000772 acyl-activating enzyme (AAE) consensus motif; other site 418127000773 AMP binding site [chemical binding]; other site 418127000774 active site 418127000775 CoA binding site [chemical binding]; other site 418127000776 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 418127000777 Coenzyme A transferase; Region: CoA_trans; smart00882 418127000778 Coenzyme A transferase; Region: CoA_trans; cl17247 418127000779 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 418127000780 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 418127000781 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 418127000782 Uncharacterized conserved protein [Function unknown]; Region: COG3189 418127000783 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 418127000784 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 418127000785 heme-binding site [chemical binding]; other site 418127000786 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 418127000787 FAD binding pocket [chemical binding]; other site 418127000788 FAD binding motif [chemical binding]; other site 418127000789 phosphate binding motif [ion binding]; other site 418127000790 beta-alpha-beta structure motif; other site 418127000791 NAD binding pocket [chemical binding]; other site 418127000792 Heme binding pocket [chemical binding]; other site 418127000793 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 418127000794 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 418127000795 tetramer (dimer of dimers) interface [polypeptide binding]; other site 418127000796 NAD binding site [chemical binding]; other site 418127000797 dimer interface [polypeptide binding]; other site 418127000798 substrate binding site [chemical binding]; other site 418127000799 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 418127000800 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 418127000801 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 418127000802 active site turn [active] 418127000803 phosphorylation site [posttranslational modification] 418127000804 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 418127000805 active site 418127000806 tetramer interface [polypeptide binding]; other site 418127000807 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 418127000808 Mga helix-turn-helix domain; Region: Mga; pfam05043 418127000809 PRD domain; Region: PRD; pfam00874 418127000810 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 418127000811 active site 418127000812 P-loop; other site 418127000813 phosphorylation site [posttranslational modification] 418127000814 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127000815 active site 418127000816 phosphorylation site [posttranslational modification] 418127000817 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127000818 active site 418127000819 phosphorylation site [posttranslational modification] 418127000820 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 418127000821 active site 418127000822 P-loop; other site 418127000823 phosphorylation site [posttranslational modification] 418127000824 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 418127000825 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 418127000826 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 418127000827 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 418127000828 putative NAD(P) binding site [chemical binding]; other site 418127000829 catalytic Zn binding site [ion binding]; other site 418127000830 structural Zn binding site [ion binding]; other site 418127000831 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 418127000832 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 418127000833 putative NAD(P) binding site [chemical binding]; other site 418127000834 catalytic Zn binding site [ion binding]; other site 418127000835 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 418127000836 substrate binding site; other site 418127000837 dimer interface; other site 418127000838 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 418127000839 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 418127000840 putative NAD(P) binding site [chemical binding]; other site 418127000841 putative catalytic Zn binding site [ion binding]; other site 418127000842 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 418127000843 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 418127000844 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 418127000845 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 418127000846 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 418127000847 substrate binding site; other site 418127000848 dimer interface; other site 418127000849 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 418127000850 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 418127000851 putative NAD(P) binding site [chemical binding]; other site 418127000852 putative catalytic Zn binding site [ion binding]; other site 418127000853 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 418127000854 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 418127000855 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 418127000856 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 418127000857 active site 418127000858 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 418127000859 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 418127000860 Hemerythrin-like domain; Region: Hr-like; cd12108 418127000861 Fe binding site [ion binding]; other site 418127000862 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 418127000863 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 418127000864 Histidine kinase; Region: His_kinase; pfam06580 418127000865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127000866 Mg2+ binding site [ion binding]; other site 418127000867 G-X-G motif; other site 418127000868 two-component response regulator; Provisional; Region: PRK14084 418127000869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127000870 active site 418127000871 phosphorylation site [posttranslational modification] 418127000872 intermolecular recognition site; other site 418127000873 dimerization interface [polypeptide binding]; other site 418127000874 LytTr DNA-binding domain; Region: LytTR; pfam04397 418127000875 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 418127000876 antiholin-like protein LrgB; Provisional; Region: PRK04288 418127000877 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 418127000878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 418127000879 DNA-binding site [nucleotide binding]; DNA binding site 418127000880 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 418127000881 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 418127000882 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 418127000883 HPr interaction site; other site 418127000884 glycerol kinase (GK) interaction site [polypeptide binding]; other site 418127000885 active site 418127000886 phosphorylation site [posttranslational modification] 418127000887 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 418127000888 beta-galactosidase; Region: BGL; TIGR03356 418127000889 Methyltransferase domain; Region: Methyltransf_31; pfam13847 418127000890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127000891 S-adenosylmethionine binding site [chemical binding]; other site 418127000892 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 418127000893 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 418127000894 substrate binding site [chemical binding]; other site 418127000895 dimer interface [polypeptide binding]; other site 418127000896 ATP binding site [chemical binding]; other site 418127000897 D-ribose pyranase; Provisional; Region: PRK11797 418127000898 Sugar transport protein; Region: Sugar_transport; pfam06800 418127000899 Transcriptional regulators [Transcription]; Region: PurR; COG1609 418127000900 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 418127000901 DNA binding site [nucleotide binding] 418127000902 domain linker motif; other site 418127000903 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 418127000904 dimerization interface [polypeptide binding]; other site 418127000905 ligand binding site [chemical binding]; other site 418127000906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000908 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 418127000909 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 418127000910 active site 418127000911 Surface antigen [General function prediction only]; Region: COG3942 418127000912 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 418127000913 Peptidase family M23; Region: Peptidase_M23; pfam01551 418127000914 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 418127000915 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 418127000916 Walker A/P-loop; other site 418127000917 ATP binding site [chemical binding]; other site 418127000918 Q-loop/lid; other site 418127000919 ABC transporter signature motif; other site 418127000920 Walker B; other site 418127000921 D-loop; other site 418127000922 H-loop/switch region; other site 418127000923 Surface antigen [General function prediction only]; Region: COG3942 418127000924 CHAP domain; Region: CHAP; pfam05257 418127000925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 418127000926 Predicted membrane protein [Function unknown]; Region: COG1511 418127000927 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 418127000928 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 418127000929 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 418127000930 Uncharacterized small protein [Function unknown]; Region: COG5417 418127000931 Predicted membrane protein [Function unknown]; Region: COG4499 418127000932 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 418127000933 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 418127000934 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 418127000935 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 418127000936 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 418127000937 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 418127000938 Uncharacterized conserved protein [Function unknown]; Region: COG5444 418127000939 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 418127000940 Protein of unknown function, DUF600; Region: DUF600; cl04640 418127000941 Protein of unknown function, DUF600; Region: DUF600; cl04640 418127000942 Protein of unknown function, DUF600; Region: DUF600; cl04640 418127000943 Protein of unknown function, DUF600; Region: DUF600; cl04640 418127000944 Protein of unknown function, DUF600; Region: DUF600; cl04640 418127000945 Protein of unknown function, DUF600; Region: DUF600; cl04640 418127000946 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 418127000947 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 418127000948 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 418127000949 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 418127000950 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 418127000951 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 418127000952 FtsX-like permease family; Region: FtsX; pfam02687 418127000953 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 418127000954 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 418127000955 Walker A/P-loop; other site 418127000956 ATP binding site [chemical binding]; other site 418127000957 Q-loop/lid; other site 418127000958 ABC transporter signature motif; other site 418127000959 Walker B; other site 418127000960 D-loop; other site 418127000961 H-loop/switch region; other site 418127000962 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 418127000963 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 418127000964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127000965 non-specific DNA binding site [nucleotide binding]; other site 418127000966 salt bridge; other site 418127000967 sequence-specific DNA binding site [nucleotide binding]; other site 418127000968 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 418127000969 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 418127000970 substrate binding site [chemical binding]; other site 418127000971 ATP binding site [chemical binding]; other site 418127000972 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 418127000973 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 418127000974 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 418127000975 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 418127000976 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 418127000977 putative transporter; Provisional; Region: PRK10484 418127000978 Na binding site [ion binding]; other site 418127000979 N-acetylneuraminate lyase; Provisional; Region: PRK04147 418127000980 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 418127000981 inhibitor site; inhibition site 418127000982 active site 418127000983 dimer interface [polypeptide binding]; other site 418127000984 catalytic residue [active] 418127000985 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 418127000986 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 418127000987 nucleotide binding site [chemical binding]; other site 418127000988 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 418127000989 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 418127000990 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 418127000991 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 418127000992 putative active site [active] 418127000993 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 418127000994 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 418127000995 putative active site cavity [active] 418127000996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 418127000997 Nucleoside recognition; Region: Gate; pfam07670 418127000998 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 418127000999 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 418127001000 PGAP1-like protein; Region: PGAP1; pfam07819 418127001001 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 418127001002 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 418127001003 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 418127001004 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 418127001005 putative active site [active] 418127001006 putative FMN binding site [chemical binding]; other site 418127001007 putative substrate binding site [chemical binding]; other site 418127001008 putative catalytic residue [active] 418127001009 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 418127001010 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 418127001011 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 418127001012 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 418127001013 lipoyl attachment site [posttranslational modification]; other site 418127001014 Replication protein C N-terminal domain; Region: RP-C; pfam03428 418127001015 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 418127001016 putative ADP-ribose binding site [chemical binding]; other site 418127001017 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 418127001018 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 418127001019 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 418127001020 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 418127001021 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 418127001022 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 418127001023 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 418127001024 NADP binding site [chemical binding]; other site 418127001025 putative substrate binding site [chemical binding]; other site 418127001026 active site 418127001027 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 418127001028 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 418127001029 active site 418127001030 P-loop; other site 418127001031 phosphorylation site [posttranslational modification] 418127001032 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127001033 active site 418127001034 phosphorylation site [posttranslational modification] 418127001035 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 418127001036 HTH domain; Region: HTH_11; pfam08279 418127001037 HTH domain; Region: HTH_11; pfam08279 418127001038 PRD domain; Region: PRD; pfam00874 418127001039 PRD domain; Region: PRD; pfam00874 418127001040 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 418127001041 active site 418127001042 P-loop; other site 418127001043 phosphorylation site [posttranslational modification] 418127001044 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127001045 active site 418127001046 phosphorylation site [posttranslational modification] 418127001047 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 418127001048 MarR family; Region: MarR_2; pfam12802 418127001049 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 418127001050 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 418127001051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 418127001052 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 418127001053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127001054 putative substrate translocation pore; other site 418127001055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127001056 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 418127001057 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 418127001058 Zn binding site [ion binding]; other site 418127001059 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 418127001060 Zn binding site [ion binding]; other site 418127001061 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 418127001062 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 418127001063 Predicted flavoprotein [General function prediction only]; Region: COG0431 418127001064 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 418127001065 Predicted membrane protein [Function unknown]; Region: COG2855 418127001066 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 418127001067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 418127001068 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 418127001069 Imelysin; Region: Peptidase_M75; pfam09375 418127001070 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 418127001071 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 418127001072 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 418127001073 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 418127001074 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 418127001075 Phage envelope protein [General function prediction only]; Region: COG5562 418127001076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127001077 non-specific DNA binding site [nucleotide binding]; other site 418127001078 salt bridge; other site 418127001079 sequence-specific DNA binding site [nucleotide binding]; other site 418127001080 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 418127001081 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 418127001082 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 418127001083 Walker A/P-loop; other site 418127001084 ATP binding site [chemical binding]; other site 418127001085 Q-loop/lid; other site 418127001086 ABC transporter signature motif; other site 418127001087 Walker B; other site 418127001088 D-loop; other site 418127001089 H-loop/switch region; other site 418127001090 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 418127001091 Predicted membrane protein [Function unknown]; Region: COG4292 418127001092 putative acyltransferase; Provisional; Region: PRK05790 418127001093 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 418127001094 dimer interface [polypeptide binding]; other site 418127001095 active site 418127001096 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 418127001097 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 418127001098 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 418127001099 THF binding site; other site 418127001100 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 418127001101 substrate binding site [chemical binding]; other site 418127001102 THF binding site; other site 418127001103 zinc-binding site [ion binding]; other site 418127001104 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 418127001105 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 418127001106 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 418127001107 FAD binding site [chemical binding]; other site 418127001108 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 418127001109 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 418127001110 homodimer interface [polypeptide binding]; other site 418127001111 substrate-cofactor binding pocket; other site 418127001112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127001113 catalytic residue [active] 418127001114 cystathionine gamma-synthase; Reviewed; Region: PRK08247 418127001115 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 418127001116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127001117 catalytic residue [active] 418127001118 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 418127001119 ParB-like nuclease domain; Region: ParB; smart00470 418127001120 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 418127001121 Mechanosensitive ion channel; Region: MS_channel; pfam00924 418127001122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 418127001123 GTP-binding protein YchF; Reviewed; Region: PRK09601 418127001124 YchF GTPase; Region: YchF; cd01900 418127001125 G1 box; other site 418127001126 GTP/Mg2+ binding site [chemical binding]; other site 418127001127 Switch I region; other site 418127001128 G2 box; other site 418127001129 Switch II region; other site 418127001130 G3 box; other site 418127001131 G4 box; other site 418127001132 G5 box; other site 418127001133 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 418127001134 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 418127001135 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 418127001136 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 418127001137 dimer interface [polypeptide binding]; other site 418127001138 ssDNA binding site [nucleotide binding]; other site 418127001139 tetramer (dimer of dimers) interface [polypeptide binding]; other site 418127001140 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 418127001141 Abi-like protein; Region: Abi_2; pfam07751 418127001142 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 418127001143 DNA binding site [nucleotide binding] 418127001144 active site 418127001145 Int/Topo IB signature motif; other site 418127001146 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 418127001148 Predicted membrane protein [Function unknown]; Region: COG3212 418127001149 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 418127001150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 418127001151 non-specific DNA binding site [nucleotide binding]; other site 418127001152 salt bridge; other site 418127001153 sequence-specific DNA binding site [nucleotide binding]; other site 418127001154 Predicted membrane protein [Function unknown]; Region: COG2261 418127001155 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 418127001156 catalytic core [active] 418127001157 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 418127001158 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 418127001159 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 418127001160 catalytic residue [active] 418127001161 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 418127001162 catalytic residues [active] 418127001163 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 418127001164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 418127001165 peroxiredoxin; Region: AhpC; TIGR03137 418127001166 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 418127001167 dimer interface [polypeptide binding]; other site 418127001168 decamer (pentamer of dimers) interface [polypeptide binding]; other site 418127001169 catalytic triad [active] 418127001170 peroxidatic and resolving cysteines [active] 418127001171 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 418127001172 dimer interface [polypeptide binding]; other site 418127001173 FMN binding site [chemical binding]; other site 418127001174 NADPH bind site [chemical binding]; other site 418127001175 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 418127001176 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 418127001177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127001178 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127001179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 418127001180 active site 418127001181 xanthine permease; Region: pbuX; TIGR03173 418127001182 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 418127001183 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 418127001184 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 418127001185 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 418127001186 active site 418127001187 GMP synthase; Reviewed; Region: guaA; PRK00074 418127001188 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 418127001189 AMP/PPi binding site [chemical binding]; other site 418127001190 candidate oxyanion hole; other site 418127001191 catalytic triad [active] 418127001192 potential glutamine specificity residues [chemical binding]; other site 418127001193 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 418127001194 ATP Binding subdomain [chemical binding]; other site 418127001195 Ligand Binding sites [chemical binding]; other site 418127001196 Dimerization subdomain; other site 418127001197 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 418127001198 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 418127001199 Int/Topo IB signature motif; other site 418127001200 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 418127001201 Helix-turn-helix domain; Region: HTH_16; pfam12645 418127001202 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 418127001203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 418127001204 DNA binding residues [nucleotide binding] 418127001205 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 418127001206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127001207 non-specific DNA binding site [nucleotide binding]; other site 418127001208 salt bridge; other site 418127001209 sequence-specific DNA binding site [nucleotide binding]; other site 418127001210 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 418127001211 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 418127001212 G1 box; other site 418127001213 putative GEF interaction site [polypeptide binding]; other site 418127001214 GTP/Mg2+ binding site [chemical binding]; other site 418127001215 Switch I region; other site 418127001216 G2 box; other site 418127001217 G3 box; other site 418127001218 Switch II region; other site 418127001219 G4 box; other site 418127001220 G5 box; other site 418127001221 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 418127001222 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 418127001223 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 418127001224 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 418127001225 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 418127001226 N-acetyl-D-glucosamine binding site [chemical binding]; other site 418127001227 catalytic residue [active] 418127001228 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 418127001229 NlpC/P60 family; Region: NLPC_P60; pfam00877 418127001230 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 418127001231 AAA-like domain; Region: AAA_10; pfam12846 418127001232 TcpE family; Region: TcpE; pfam12648 418127001233 Antirestriction protein (ArdA); Region: ArdA; pfam07275 418127001234 Abortive infection C-terminus; Region: Abi_C; pfam14355 418127001235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127001236 non-specific DNA binding site [nucleotide binding]; other site 418127001237 salt bridge; other site 418127001238 sequence-specific DNA binding site [nucleotide binding]; other site 418127001239 Replication initiation factor; Region: Rep_trans; pfam02486 418127001240 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 418127001241 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 418127001242 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 418127001243 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 418127001244 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 418127001245 Part of AAA domain; Region: AAA_19; pfam13245 418127001246 Family description; Region: UvrD_C_2; pfam13538 418127001247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 418127001248 AAA domain; Region: AAA_21; pfam13304 418127001249 Walker A/P-loop; other site 418127001250 ATP binding site [chemical binding]; other site 418127001251 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 418127001252 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 418127001253 putative active site [active] 418127001254 putative metal-binding site [ion binding]; other site 418127001255 Transposase, Mutator family; Region: Transposase_mut; pfam00872 418127001256 MULE transposase domain; Region: MULE; pfam10551 418127001257 PemK-like protein; Region: PemK; pfam02452 418127001258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 418127001259 Transposase; Region: HTH_Tnp_1; cl17663 418127001260 Predicted membrane protein [Function unknown]; Region: COG3759 418127001261 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 418127001262 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 418127001263 NADP binding site [chemical binding]; other site 418127001264 superantigen-like protein; Reviewed; Region: PRK13037 418127001265 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001266 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001267 superantigen-like protein; Reviewed; Region: PRK13041 418127001268 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001269 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001270 superantigen-like protein; Reviewed; Region: PRK13335 418127001271 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001272 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001273 superantigen-like protein; Reviewed; Region: PRK13042 418127001274 Mucin-like glycoprotein; Region: Mucin; pfam01456 418127001275 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001276 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001277 superantigen-like protein 5; Reviewed; Region: PRK13035 418127001278 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001279 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001280 superantigen-like protein 7; Reviewed; Region: PRK13346 418127001281 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001282 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001283 superantigen-like protein; Reviewed; Region: PRK13039 418127001284 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001285 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001286 superantigen-like protein; Reviewed; Region: PRK13345 418127001287 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001288 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001289 superantigen-like protein 5; Reviewed; Region: PRK13035 418127001290 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001291 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001292 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 418127001293 HsdM N-terminal domain; Region: HsdM_N; pfam12161 418127001294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127001295 S-adenosylmethionine binding site [chemical binding]; other site 418127001296 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 418127001297 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 418127001298 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 418127001299 superantigen-like protein; Reviewed; Region: PRK13036 418127001300 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001301 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001302 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127001303 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127001304 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127001305 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127001306 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127001307 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127001308 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127001309 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127001310 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127001311 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127001312 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 418127001313 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 418127001314 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 418127001315 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 418127001316 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 418127001317 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 418127001318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 418127001319 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 418127001320 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 418127001321 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 418127001322 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 418127001323 active site 418127001324 Esterase/lipase [General function prediction only]; Region: COG1647 418127001325 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 418127001326 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 418127001327 Na2 binding site [ion binding]; other site 418127001328 putative substrate binding site 1 [chemical binding]; other site 418127001329 Na binding site 1 [ion binding]; other site 418127001330 putative substrate binding site 2 [chemical binding]; other site 418127001331 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 418127001332 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 418127001333 dimer interface [polypeptide binding]; other site 418127001334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127001335 catalytic residue [active] 418127001336 cystathionine beta-lyase; Provisional; Region: PRK07671 418127001337 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 418127001338 homodimer interface [polypeptide binding]; other site 418127001339 substrate-cofactor binding pocket; other site 418127001340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127001341 catalytic residue [active] 418127001342 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 418127001343 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 418127001344 Walker A/P-loop; other site 418127001345 ATP binding site [chemical binding]; other site 418127001346 Q-loop/lid; other site 418127001347 ABC transporter signature motif; other site 418127001348 Walker B; other site 418127001349 D-loop; other site 418127001350 H-loop/switch region; other site 418127001351 NIL domain; Region: NIL; pfam09383 418127001352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127001353 dimer interface [polypeptide binding]; other site 418127001354 conserved gate region; other site 418127001355 ABC-ATPase subunit interface; other site 418127001356 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 418127001357 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 418127001358 LysM domain; Region: LysM; pfam01476 418127001359 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 418127001360 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 418127001361 Surface antigen [General function prediction only]; Region: COG3942 418127001362 CHAP domain; Region: CHAP; pfam05257 418127001363 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 418127001364 nudix motif; other site 418127001365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127001366 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 418127001367 Coenzyme A binding pocket [chemical binding]; other site 418127001368 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 418127001369 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 418127001370 Transcriptional regulator [Transcription]; Region: LysR; COG0583 418127001371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 418127001372 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 418127001373 dimerization interface [polypeptide binding]; other site 418127001374 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 418127001375 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 418127001376 active site 418127001377 dimer interface [polypeptide binding]; other site 418127001378 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 418127001379 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 418127001380 active site 418127001381 FMN binding site [chemical binding]; other site 418127001382 substrate binding site [chemical binding]; other site 418127001383 3Fe-4S cluster binding site [ion binding]; other site 418127001384 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 418127001385 domain interface; other site 418127001386 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 418127001387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 418127001388 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 418127001389 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 418127001390 active site turn [active] 418127001391 phosphorylation site [posttranslational modification] 418127001392 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 418127001393 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 418127001394 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 418127001395 Ca binding site [ion binding]; other site 418127001396 active site 418127001397 catalytic site [active] 418127001398 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 418127001399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 418127001400 DNA-binding site [nucleotide binding]; DNA binding site 418127001401 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 418127001402 UTRA domain; Region: UTRA; pfam07702 418127001403 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 418127001404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127001405 Coenzyme A binding pocket [chemical binding]; other site 418127001406 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 418127001407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127001408 Walker A motif; other site 418127001409 ATP binding site [chemical binding]; other site 418127001410 Walker B motif; other site 418127001411 arginine finger; other site 418127001412 hypothetical protein; Validated; Region: PRK00153 418127001413 recombination protein RecR; Reviewed; Region: recR; PRK00076 418127001414 RecR protein; Region: RecR; pfam02132 418127001415 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 418127001416 putative active site [active] 418127001417 putative metal-binding site [ion binding]; other site 418127001418 tetramer interface [polypeptide binding]; other site 418127001419 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 418127001420 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 418127001421 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127001422 catalytic residue [active] 418127001423 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 418127001424 thymidylate kinase; Validated; Region: tmk; PRK00698 418127001425 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 418127001426 TMP-binding site; other site 418127001427 ATP-binding site [chemical binding]; other site 418127001428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 418127001429 DNA polymerase III subunit delta'; Validated; Region: PRK08058 418127001430 DNA polymerase III subunit delta'; Validated; Region: PRK08485 418127001431 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 418127001432 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 418127001433 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 418127001434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127001435 S-adenosylmethionine binding site [chemical binding]; other site 418127001436 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 418127001437 GIY-YIG motif/motif A; other site 418127001438 putative active site [active] 418127001439 putative metal binding site [ion binding]; other site 418127001440 Predicted methyltransferases [General function prediction only]; Region: COG0313 418127001441 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 418127001442 putative SAM binding site [chemical binding]; other site 418127001443 putative homodimer interface [polypeptide binding]; other site 418127001444 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 418127001445 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 418127001446 active site 418127001447 HIGH motif; other site 418127001448 KMSKS motif; other site 418127001449 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 418127001450 tRNA binding surface [nucleotide binding]; other site 418127001451 anticodon binding site; other site 418127001452 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 418127001453 dimer interface [polypeptide binding]; other site 418127001454 putative tRNA-binding site [nucleotide binding]; other site 418127001455 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 418127001456 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 418127001457 active site 418127001458 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 418127001459 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 418127001460 putative active site [active] 418127001461 putative metal binding site [ion binding]; other site 418127001462 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 418127001463 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 418127001464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127001465 S-adenosylmethionine binding site [chemical binding]; other site 418127001466 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 418127001467 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 418127001468 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 418127001469 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 418127001470 pur operon repressor; Provisional; Region: PRK09213 418127001471 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 418127001472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 418127001473 active site 418127001474 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 418127001475 homotrimer interaction site [polypeptide binding]; other site 418127001476 putative active site [active] 418127001477 regulatory protein SpoVG; Reviewed; Region: PRK13259 418127001478 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 418127001479 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 418127001480 Substrate binding site; other site 418127001481 Mg++ binding site; other site 418127001482 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 418127001483 active site 418127001484 substrate binding site [chemical binding]; other site 418127001485 CoA binding site [chemical binding]; other site 418127001486 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 418127001487 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 418127001488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 418127001489 active site 418127001490 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 418127001491 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 418127001492 5S rRNA interface [nucleotide binding]; other site 418127001493 CTC domain interface [polypeptide binding]; other site 418127001494 L16 interface [polypeptide binding]; other site 418127001495 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 418127001496 putative active site [active] 418127001497 catalytic residue [active] 418127001498 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 418127001499 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 418127001500 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127001501 ATP binding site [chemical binding]; other site 418127001502 putative Mg++ binding site [ion binding]; other site 418127001503 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127001504 nucleotide binding region [chemical binding]; other site 418127001505 ATP-binding site [chemical binding]; other site 418127001506 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 418127001507 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 418127001508 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 418127001509 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 418127001510 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 418127001511 putative SAM binding site [chemical binding]; other site 418127001512 putative homodimer interface [polypeptide binding]; other site 418127001513 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 418127001514 homodimer interface [polypeptide binding]; other site 418127001515 metal binding site [ion binding]; metal-binding site 418127001516 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 418127001517 RNA binding surface [nucleotide binding]; other site 418127001518 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 418127001519 Septum formation initiator; Region: DivIC; pfam04977 418127001520 hypothetical protein; Provisional; Region: PRK08582 418127001521 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 418127001522 RNA binding site [nucleotide binding]; other site 418127001523 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 418127001524 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 418127001525 Ligand Binding Site [chemical binding]; other site 418127001526 TilS substrate C-terminal domain; Region: TilS_C; smart00977 418127001527 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 418127001528 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 418127001529 active site 418127001530 FtsH Extracellular; Region: FtsH_ext; pfam06480 418127001531 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 418127001532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127001533 Walker A motif; other site 418127001534 ATP binding site [chemical binding]; other site 418127001535 Walker B motif; other site 418127001536 arginine finger; other site 418127001537 Peptidase family M41; Region: Peptidase_M41; pfam01434 418127001538 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 418127001539 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 418127001540 dimerization interface [polypeptide binding]; other site 418127001541 domain crossover interface; other site 418127001542 redox-dependent activation switch; other site 418127001543 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 418127001544 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 418127001545 dimer interface [polypeptide binding]; other site 418127001546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127001547 catalytic residue [active] 418127001548 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 418127001549 dihydropteroate synthase; Region: DHPS; TIGR01496 418127001550 substrate binding pocket [chemical binding]; other site 418127001551 dimer interface [polypeptide binding]; other site 418127001552 inhibitor binding site; inhibition site 418127001553 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 418127001554 homooctamer interface [polypeptide binding]; other site 418127001555 active site 418127001556 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 418127001557 catalytic center binding site [active] 418127001558 ATP binding site [chemical binding]; other site 418127001559 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 418127001560 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 418127001561 dimer interface [polypeptide binding]; other site 418127001562 putative anticodon binding site; other site 418127001563 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 418127001564 motif 1; other site 418127001565 active site 418127001566 motif 2; other site 418127001567 motif 3; other site 418127001568 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 418127001569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 418127001570 DNA-binding site [nucleotide binding]; DNA binding site 418127001571 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 418127001572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127001573 homodimer interface [polypeptide binding]; other site 418127001574 catalytic residue [active] 418127001575 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 418127001576 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 418127001577 active site 418127001578 multimer interface [polypeptide binding]; other site 418127001579 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 418127001580 predicted active site [active] 418127001581 catalytic triad [active] 418127001582 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 418127001583 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 418127001584 Nucleoside recognition; Region: Gate; pfam07670 418127001585 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 418127001586 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 418127001587 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 418127001588 UvrB/uvrC motif; Region: UVR; pfam02151 418127001589 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 418127001590 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 418127001591 ADP binding site [chemical binding]; other site 418127001592 phosphagen binding site; other site 418127001593 substrate specificity loop; other site 418127001594 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 418127001595 Clp amino terminal domain; Region: Clp_N; pfam02861 418127001596 Clp amino terminal domain; Region: Clp_N; pfam02861 418127001597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127001598 Walker A motif; other site 418127001599 ATP binding site [chemical binding]; other site 418127001600 Walker B motif; other site 418127001601 arginine finger; other site 418127001602 UvrB/uvrC motif; Region: UVR; pfam02151 418127001603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127001604 Walker A motif; other site 418127001605 ATP binding site [chemical binding]; other site 418127001606 Walker B motif; other site 418127001607 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 418127001608 DNA repair protein RadA; Provisional; Region: PRK11823 418127001609 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 418127001610 Walker A motif/ATP binding site; other site 418127001611 ATP binding site [chemical binding]; other site 418127001612 Walker B motif; other site 418127001613 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 418127001614 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 418127001615 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 418127001616 putative active site [active] 418127001617 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 418127001618 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 418127001619 active site 418127001620 HIGH motif; other site 418127001621 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 418127001622 active site 418127001623 KMSKS motif; other site 418127001624 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 418127001625 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 418127001626 trimer interface [polypeptide binding]; other site 418127001627 active site 418127001628 substrate binding site [chemical binding]; other site 418127001629 CoA binding site [chemical binding]; other site 418127001630 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 418127001631 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 418127001632 active site 418127001633 HIGH motif; other site 418127001634 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 418127001635 KMSKS motif; other site 418127001636 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 418127001637 tRNA binding surface [nucleotide binding]; other site 418127001638 anticodon binding site; other site 418127001639 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 418127001640 active site 418127001641 dimerization interface [polypeptide binding]; other site 418127001642 metal binding site [ion binding]; metal-binding site 418127001643 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 418127001644 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 418127001645 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 418127001646 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 418127001647 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 418127001648 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 418127001649 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 418127001650 DNA binding residues [nucleotide binding] 418127001651 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 418127001652 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 418127001653 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 418127001654 putative homodimer interface [polypeptide binding]; other site 418127001655 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 418127001656 heterodimer interface [polypeptide binding]; other site 418127001657 homodimer interface [polypeptide binding]; other site 418127001658 similar to hypothetical protein 418127001659 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 418127001660 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 418127001661 23S rRNA interface [nucleotide binding]; other site 418127001662 L7/L12 interface [polypeptide binding]; other site 418127001663 putative thiostrepton binding site; other site 418127001664 L25 interface [polypeptide binding]; other site 418127001665 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 418127001666 mRNA/rRNA interface [nucleotide binding]; other site 418127001667 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 418127001668 23S rRNA interface [nucleotide binding]; other site 418127001669 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 418127001670 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 418127001671 peripheral dimer interface [polypeptide binding]; other site 418127001672 core dimer interface [polypeptide binding]; other site 418127001673 L10 interface [polypeptide binding]; other site 418127001674 L11 interface [polypeptide binding]; other site 418127001675 putative EF-Tu interaction site [polypeptide binding]; other site 418127001676 putative EF-G interaction site [polypeptide binding]; other site 418127001677 Methyltransferase domain; Region: Methyltransf_31; pfam13847 418127001678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127001679 S-adenosylmethionine binding site [chemical binding]; other site 418127001680 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 418127001681 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 418127001682 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 418127001683 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 418127001684 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 418127001685 RPB10 interaction site [polypeptide binding]; other site 418127001686 RPB1 interaction site [polypeptide binding]; other site 418127001687 RPB11 interaction site [polypeptide binding]; other site 418127001688 RPB3 interaction site [polypeptide binding]; other site 418127001689 RPB12 interaction site [polypeptide binding]; other site 418127001690 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 418127001691 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 418127001692 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 418127001693 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 418127001694 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 418127001695 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 418127001696 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 418127001697 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 418127001698 G-loop; other site 418127001699 DNA binding site [nucleotide binding] 418127001700 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 418127001701 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 418127001702 S17 interaction site [polypeptide binding]; other site 418127001703 S8 interaction site; other site 418127001704 16S rRNA interaction site [nucleotide binding]; other site 418127001705 streptomycin interaction site [chemical binding]; other site 418127001706 23S rRNA interaction site [nucleotide binding]; other site 418127001707 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 418127001708 30S ribosomal protein S7; Validated; Region: PRK05302 418127001709 elongation factor G; Reviewed; Region: PRK00007 418127001710 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 418127001711 G1 box; other site 418127001712 putative GEF interaction site [polypeptide binding]; other site 418127001713 GTP/Mg2+ binding site [chemical binding]; other site 418127001714 Switch I region; other site 418127001715 G2 box; other site 418127001716 G3 box; other site 418127001717 Switch II region; other site 418127001718 G4 box; other site 418127001719 G5 box; other site 418127001720 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 418127001721 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 418127001722 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 418127001723 elongation factor Tu; Reviewed; Region: PRK00049 418127001724 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 418127001725 G1 box; other site 418127001726 GEF interaction site [polypeptide binding]; other site 418127001727 GTP/Mg2+ binding site [chemical binding]; other site 418127001728 Switch I region; other site 418127001729 G2 box; other site 418127001730 G3 box; other site 418127001731 Switch II region; other site 418127001732 G4 box; other site 418127001733 G5 box; other site 418127001734 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 418127001735 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 418127001736 Antibiotic Binding Site [chemical binding]; other site 418127001737 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 418127001738 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 418127001739 metal binding site [ion binding]; metal-binding site 418127001740 dimer interface [polypeptide binding]; other site 418127001741 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 418127001742 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 418127001743 substrate-cofactor binding pocket; other site 418127001744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127001745 catalytic residue [active] 418127001746 chaperone protein HchA; Provisional; Region: PRK04155 418127001747 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 418127001748 dimer interface [polypeptide binding]; other site 418127001749 metal binding site [ion binding]; metal-binding site 418127001750 potential oxyanion hole; other site 418127001751 potential catalytic triad [active] 418127001752 conserved cys residue [active] 418127001753 ribulokinase; Provisional; Region: PRK04123 418127001754 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 418127001755 N- and C-terminal domain interface [polypeptide binding]; other site 418127001756 active site 418127001757 MgATP binding site [chemical binding]; other site 418127001758 catalytic site [active] 418127001759 metal binding site [ion binding]; metal-binding site 418127001760 carbohydrate binding site [chemical binding]; other site 418127001761 homodimer interface [polypeptide binding]; other site 418127001762 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 418127001763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127001764 NAD(P) binding site [chemical binding]; other site 418127001765 active site 418127001766 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 418127001767 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 418127001768 homodimer interface [polypeptide binding]; other site 418127001769 substrate-cofactor binding pocket; other site 418127001770 catalytic residue [active] 418127001771 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 418127001772 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127001773 motif II; other site 418127001774 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 418127001775 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 418127001776 Substrate-binding site [chemical binding]; other site 418127001777 Substrate specificity [chemical binding]; other site 418127001778 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 418127001779 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 418127001780 Substrate-binding site [chemical binding]; other site 418127001781 Substrate specificity [chemical binding]; other site 418127001782 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 418127001783 nucleoside/Zn binding site; other site 418127001784 dimer interface [polypeptide binding]; other site 418127001785 catalytic motif [active] 418127001786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127001787 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 418127001788 active site 418127001789 motif I; other site 418127001790 motif II; other site 418127001791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127001792 Predicted flavoprotein [General function prediction only]; Region: COG0431 418127001793 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 418127001794 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 418127001795 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 418127001796 Cna protein B-type domain; Region: Cna_B; pfam05738 418127001797 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 418127001798 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 418127001799 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 418127001800 Cna protein B-type domain; Region: Cna_B; pfam05738 418127001801 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 418127001802 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 418127001803 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 418127001804 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 418127001805 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 418127001806 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 418127001807 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 418127001808 Cna protein B-type domain; Region: Cna_B; pfam05738 418127001809 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 418127001810 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 418127001811 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 418127001812 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 418127001813 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 418127001814 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 418127001815 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 418127001816 putative GTP cyclohydrolase; Provisional; Region: PRK13674 418127001817 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 418127001818 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 418127001819 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 418127001820 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 418127001821 active site 418127001822 trimer interface [polypeptide binding]; other site 418127001823 allosteric site; other site 418127001824 active site lid [active] 418127001825 hexamer (dimer of trimers) interface [polypeptide binding]; other site 418127001826 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 418127001827 active site 418127001828 dimer interface [polypeptide binding]; other site 418127001829 magnesium binding site [ion binding]; other site 418127001830 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 418127001831 tetramer interface [polypeptide binding]; other site 418127001832 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 418127001833 active site 418127001834 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 418127001835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127001836 motif II; other site 418127001837 proline/glycine betaine transporter; Provisional; Region: PRK10642 418127001838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127001839 putative substrate translocation pore; other site 418127001840 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 418127001841 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 418127001842 acyl-activating enzyme (AAE) consensus motif; other site 418127001843 AMP binding site [chemical binding]; other site 418127001844 active site 418127001845 CoA binding site [chemical binding]; other site 418127001846 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 418127001847 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 418127001848 dimer interface [polypeptide binding]; other site 418127001849 active site 418127001850 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 418127001851 dimer interface [polypeptide binding]; other site 418127001852 substrate binding site [chemical binding]; other site 418127001853 ATP binding site [chemical binding]; other site 418127001854 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 418127001855 ligand binding site [chemical binding]; other site 418127001856 active site 418127001857 UGI interface [polypeptide binding]; other site 418127001858 catalytic site [active] 418127001859 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 418127001860 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 418127001861 Uncharacterized conserved protein [Function unknown]; Region: COG3610 418127001862 Uncharacterized conserved protein [Function unknown]; Region: COG2966 418127001863 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 418127001864 putative heme peroxidase; Provisional; Region: PRK12276 418127001865 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 418127001866 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 418127001867 mevalonate kinase; Region: mevalon_kin; TIGR00549 418127001868 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 418127001869 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 418127001870 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 418127001871 diphosphomevalonate decarboxylase; Region: PLN02407 418127001872 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 418127001873 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 418127001874 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 418127001875 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 418127001876 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 418127001877 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 418127001878 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 418127001879 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 418127001880 Predicted transcriptional regulator [Transcription]; Region: COG1959 418127001881 Transcriptional regulator; Region: Rrf2; pfam02082 418127001882 LXG domain of WXG superfamily; Region: LXG; pfam04740 418127001883 Protein of unknown function (DUF443); Region: DUF443; pfam04276 418127001884 Protein of unknown function (DUF443); Region: DUF443; pfam04276 418127001885 Protein of unknown function (DUF443); Region: DUF443; pfam04276 418127001886 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 418127001887 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 418127001888 active site 418127001889 catalytic tetrad [active] 418127001890 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 418127001891 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 418127001892 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 418127001893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127001894 Coenzyme A binding pocket [chemical binding]; other site 418127001895 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 418127001896 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 418127001897 Zn2+ binding site [ion binding]; other site 418127001898 Mg2+ binding site [ion binding]; other site 418127001899 YwhD family; Region: YwhD; pfam08741 418127001900 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 418127001901 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 418127001902 NAD binding site [chemical binding]; other site 418127001903 substrate binding site [chemical binding]; other site 418127001904 catalytic Zn binding site [ion binding]; other site 418127001905 tetramer interface [polypeptide binding]; other site 418127001906 structural Zn binding site [ion binding]; other site 418127001907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 418127001908 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 418127001909 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 418127001910 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 418127001911 active site 418127001912 HIGH motif; other site 418127001913 KMSK motif region; other site 418127001914 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 418127001915 tRNA binding surface [nucleotide binding]; other site 418127001916 anticodon binding site; other site 418127001917 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 418127001918 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 418127001919 minor groove reading motif; other site 418127001920 helix-hairpin-helix signature motif; other site 418127001921 substrate binding pocket [chemical binding]; other site 418127001922 active site 418127001923 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 418127001924 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 418127001925 putative binding site residues; other site 418127001926 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 418127001927 ABC-ATPase subunit interface; other site 418127001928 dimer interface [polypeptide binding]; other site 418127001929 putative PBP binding regions; other site 418127001930 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 418127001931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127001932 motif II; other site 418127001933 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 418127001934 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 418127001935 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 418127001936 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 418127001937 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 418127001938 Transcriptional regulators [Transcription]; Region: MarR; COG1846 418127001939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 418127001940 Protein of unknown function, DUF606; Region: DUF606; pfam04657 418127001941 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 418127001942 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 418127001943 active site 418127001944 DNA binding site [nucleotide binding] 418127001945 Int/Topo IB signature motif; other site 418127001946 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 418127001947 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 418127001948 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 418127001949 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 418127001950 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 418127001951 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 418127001952 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 418127001953 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 418127001954 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 418127001955 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 418127001956 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 418127001957 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 418127001958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127001959 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127001960 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 418127001961 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 418127001962 metal binding site [ion binding]; metal-binding site 418127001963 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 418127001964 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 418127001965 ABC-ATPase subunit interface; other site 418127001966 dimer interface [polypeptide binding]; other site 418127001967 putative PBP binding regions; other site 418127001968 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 418127001969 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 418127001970 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 418127001971 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 418127001972 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 418127001973 FeoA domain; Region: FeoA; pfam04023 418127001974 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 418127001975 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 418127001976 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 418127001977 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 418127001978 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 418127001979 Walker A/P-loop; other site 418127001980 ATP binding site [chemical binding]; other site 418127001981 Q-loop/lid; other site 418127001982 ABC transporter signature motif; other site 418127001983 Walker B; other site 418127001984 D-loop; other site 418127001985 H-loop/switch region; other site 418127001986 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 418127001987 ABC-2 type transporter; Region: ABC2_membrane; cl17235 418127001988 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 418127001989 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 418127001990 active site 418127001991 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 418127001992 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 418127001993 active site 418127001994 nucleotide binding site [chemical binding]; other site 418127001995 HIGH motif; other site 418127001996 KMSKS motif; other site 418127001997 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 418127001998 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 418127001999 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 418127002000 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 418127002001 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 418127002002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 418127002003 Walker A/P-loop; other site 418127002004 ATP binding site [chemical binding]; other site 418127002005 Q-loop/lid; other site 418127002006 ABC transporter signature motif; other site 418127002007 Walker B; other site 418127002008 D-loop; other site 418127002009 H-loop/switch region; other site 418127002010 similar to hypothetical protein 418127002011 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 418127002012 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 418127002013 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 418127002014 Uncharacterized conserved protein [Function unknown]; Region: COG1284 418127002015 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 418127002016 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 418127002017 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 418127002018 Walker A/P-loop; other site 418127002019 ATP binding site [chemical binding]; other site 418127002020 Q-loop/lid; other site 418127002021 ABC transporter signature motif; other site 418127002022 Walker B; other site 418127002023 D-loop; other site 418127002024 H-loop/switch region; other site 418127002025 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 418127002026 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 418127002027 ABC-ATPase subunit interface; other site 418127002028 dimer interface [polypeptide binding]; other site 418127002029 putative PBP binding regions; other site 418127002030 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 418127002031 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 418127002032 ABC-ATPase subunit interface; other site 418127002033 dimer interface [polypeptide binding]; other site 418127002034 putative PBP binding regions; other site 418127002035 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 418127002036 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 418127002037 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 418127002038 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 418127002039 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 418127002040 Uncharacterized membrane protein [Function unknown]; Region: COG3949 418127002041 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 418127002042 Na binding site [ion binding]; other site 418127002043 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 418127002044 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 418127002045 substrate binding pocket [chemical binding]; other site 418127002046 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 418127002047 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 418127002048 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127002049 Coenzyme A binding pocket [chemical binding]; other site 418127002050 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 418127002051 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 418127002052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127002053 NAD(P) binding site [chemical binding]; other site 418127002054 active site 418127002055 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127002056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127002057 active site 418127002058 phosphorylation site [posttranslational modification] 418127002059 intermolecular recognition site; other site 418127002060 dimerization interface [polypeptide binding]; other site 418127002061 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 418127002062 DNA binding site [nucleotide binding] 418127002063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 418127002064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 418127002065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127002066 ATP binding site [chemical binding]; other site 418127002067 Mg2+ binding site [ion binding]; other site 418127002068 G-X-G motif; other site 418127002069 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 418127002070 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 418127002071 Walker A/P-loop; other site 418127002072 ATP binding site [chemical binding]; other site 418127002073 Q-loop/lid; other site 418127002074 ABC transporter signature motif; other site 418127002075 Walker B; other site 418127002076 D-loop; other site 418127002077 H-loop/switch region; other site 418127002078 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 418127002079 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 418127002080 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 418127002081 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 418127002082 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 418127002083 Surface antigen [General function prediction only]; Region: COG3942 418127002084 CHAP domain; Region: CHAP; pfam05257 418127002085 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 418127002086 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 418127002087 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 418127002088 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 418127002089 Transcriptional regulator; Region: Transcrip_reg; cl00361 418127002090 Uncharacterized conserved protein [Function unknown]; Region: COG3542 418127002091 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 418127002092 Transcriptional regulator [Transcription]; Region: LysR; COG0583 418127002093 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 418127002094 dimerization interface [polypeptide binding]; other site 418127002095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127002096 sugar efflux transporter; Region: 2A0120; TIGR00899 418127002097 putative substrate translocation pore; other site 418127002098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 418127002099 Serine incorporator (Serinc); Region: Serinc; pfam03348 418127002100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127002101 Coenzyme A binding pocket [chemical binding]; other site 418127002102 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 418127002103 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 418127002104 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 418127002105 hypothetical protein; Validated; Region: PRK00124 418127002106 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 418127002107 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 418127002108 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 418127002109 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 418127002110 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 418127002111 Walker A/P-loop; other site 418127002112 ATP binding site [chemical binding]; other site 418127002113 Q-loop/lid; other site 418127002114 ABC transporter signature motif; other site 418127002115 Walker B; other site 418127002116 D-loop; other site 418127002117 H-loop/switch region; other site 418127002118 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 418127002119 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 418127002120 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 418127002121 Walker A/P-loop; other site 418127002122 ATP binding site [chemical binding]; other site 418127002123 Q-loop/lid; other site 418127002124 ABC transporter signature motif; other site 418127002125 Walker B; other site 418127002126 D-loop; other site 418127002127 H-loop/switch region; other site 418127002128 Transcriptional regulators [Transcription]; Region: MarR; COG1846 418127002129 MarR family; Region: MarR; pfam01047 418127002130 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 418127002131 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 418127002132 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 418127002133 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 418127002134 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 418127002135 active site 418127002136 catalytic tetrad [active] 418127002137 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 418127002138 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 418127002139 transmembrane helices; other site 418127002140 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 418127002141 DNA photolyase; Region: DNA_photolyase; pfam00875 418127002142 Predicted membrane protein [Function unknown]; Region: COG4330 418127002143 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 418127002144 trimer interface [polypeptide binding]; other site 418127002145 putative Zn binding site [ion binding]; other site 418127002146 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 418127002147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127002148 putative substrate translocation pore; other site 418127002149 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 418127002150 putative deacylase active site [active] 418127002151 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 418127002152 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 418127002153 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 418127002154 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 418127002155 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 418127002156 putative substrate binding site [chemical binding]; other site 418127002157 putative ATP binding site [chemical binding]; other site 418127002158 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 418127002159 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127002160 active site 418127002161 phosphorylation site [posttranslational modification] 418127002162 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 418127002163 active site 418127002164 P-loop; other site 418127002165 phosphorylation site [posttranslational modification] 418127002166 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 418127002167 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 418127002168 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 418127002169 active site 418127002170 dimer interface [polypeptide binding]; other site 418127002171 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 418127002172 Domain of unknown function DUF21; Region: DUF21; pfam01595 418127002173 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 418127002174 Transporter associated domain; Region: CorC_HlyC; pfam03471 418127002175 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 418127002176 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 418127002177 active site 418127002178 catalytic tetrad [active] 418127002179 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 418127002180 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 418127002181 Ligand binding site; other site 418127002182 Putative Catalytic site; other site 418127002183 DXD motif; other site 418127002184 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 418127002185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 418127002186 dimer interface [polypeptide binding]; other site 418127002187 phosphorylation site [posttranslational modification] 418127002188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127002189 ATP binding site [chemical binding]; other site 418127002190 Mg2+ binding site [ion binding]; other site 418127002191 G-X-G motif; other site 418127002192 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127002193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127002194 active site 418127002195 phosphorylation site [posttranslational modification] 418127002196 intermolecular recognition site; other site 418127002197 dimerization interface [polypeptide binding]; other site 418127002198 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 418127002199 DNA binding site [nucleotide binding] 418127002200 Electron transfer DM13; Region: DM13; pfam10517 418127002201 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 418127002202 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 418127002203 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 418127002204 active site 418127002205 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 418127002206 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 418127002207 Ligand Binding Site [chemical binding]; other site 418127002208 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 418127002209 Glutamine amidotransferase class-I; Region: GATase; pfam00117 418127002210 glutamine binding [chemical binding]; other site 418127002211 catalytic triad [active] 418127002212 aminodeoxychorismate synthase; Provisional; Region: PRK07508 418127002213 chorismate binding enzyme; Region: Chorismate_bind; cl10555 418127002214 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 418127002215 substrate-cofactor binding pocket; other site 418127002216 Aminotransferase class IV; Region: Aminotran_4; pfam01063 418127002217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127002218 catalytic residue [active] 418127002219 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 418127002220 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 418127002221 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 418127002222 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 418127002223 Sulfatase; Region: Sulfatase; pfam00884 418127002224 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 418127002225 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 418127002226 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 418127002227 ABC transporter; Region: ABC_tran_2; pfam12848 418127002228 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 418127002229 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 418127002230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127002231 ATP binding site [chemical binding]; other site 418127002232 putative Mg++ binding site [ion binding]; other site 418127002233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127002234 nucleotide binding region [chemical binding]; other site 418127002235 ATP-binding site [chemical binding]; other site 418127002236 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 418127002237 HRDC domain; Region: HRDC; pfam00570 418127002238 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 418127002239 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 418127002240 Walker A/P-loop; other site 418127002241 ATP binding site [chemical binding]; other site 418127002242 Q-loop/lid; other site 418127002243 ABC transporter signature motif; other site 418127002244 Walker B; other site 418127002245 D-loop; other site 418127002246 H-loop/switch region; other site 418127002247 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 418127002248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127002249 dimer interface [polypeptide binding]; other site 418127002250 conserved gate region; other site 418127002251 ABC-ATPase subunit interface; other site 418127002252 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 418127002253 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 418127002254 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 418127002255 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 418127002256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127002257 homodimer interface [polypeptide binding]; other site 418127002258 catalytic residue [active] 418127002259 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 418127002260 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 418127002261 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 418127002262 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 418127002263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127002264 putative substrate translocation pore; other site 418127002265 POT family; Region: PTR2; cl17359 418127002266 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 418127002267 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 418127002268 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 418127002269 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 418127002270 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 418127002271 Class I ribonucleotide reductase; Region: RNR_I; cd01679 418127002272 active site 418127002273 dimer interface [polypeptide binding]; other site 418127002274 catalytic residues [active] 418127002275 effector binding site; other site 418127002276 R2 peptide binding site; other site 418127002277 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 418127002278 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 418127002279 dimer interface [polypeptide binding]; other site 418127002280 putative radical transfer pathway; other site 418127002281 diiron center [ion binding]; other site 418127002282 tyrosyl radical; other site 418127002283 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 418127002284 ABC-ATPase subunit interface; other site 418127002285 dimer interface [polypeptide binding]; other site 418127002286 putative PBP binding regions; other site 418127002287 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 418127002288 ABC-ATPase subunit interface; other site 418127002289 dimer interface [polypeptide binding]; other site 418127002290 putative PBP binding regions; other site 418127002291 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 418127002292 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 418127002293 Walker A/P-loop; other site 418127002294 ATP binding site [chemical binding]; other site 418127002295 Q-loop/lid; other site 418127002296 ABC transporter signature motif; other site 418127002297 Walker B; other site 418127002298 D-loop; other site 418127002299 H-loop/switch region; other site 418127002300 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 418127002301 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 418127002302 putative ligand binding residues [chemical binding]; other site 418127002303 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 418127002304 CHY zinc finger; Region: zf-CHY; pfam05495 418127002305 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 418127002306 FAD binding domain; Region: FAD_binding_4; pfam01565 418127002307 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 418127002308 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 418127002309 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 418127002310 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 418127002311 peptidase T; Region: peptidase-T; TIGR01882 418127002312 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 418127002313 metal binding site [ion binding]; metal-binding site 418127002314 dimer interface [polypeptide binding]; other site 418127002315 Uncharacterized conserved protein [Function unknown]; Region: COG3610 418127002316 Uncharacterized conserved protein [Function unknown]; Region: COG2966 418127002317 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 418127002318 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 418127002319 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 418127002320 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 418127002321 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 418127002322 metal binding site [ion binding]; metal-binding site 418127002323 active site 418127002324 I-site; other site 418127002325 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 418127002326 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 418127002327 Mg++ binding site [ion binding]; other site 418127002328 putative catalytic motif [active] 418127002329 substrate binding site [chemical binding]; other site 418127002330 Uncharacterized conserved protein [Function unknown]; Region: COG1739 418127002331 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 418127002332 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 418127002333 EDD domain protein, DegV family; Region: DegV; TIGR00762 418127002334 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 418127002335 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 418127002336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 418127002337 putative Mg++ binding site [ion binding]; other site 418127002338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127002339 nucleotide binding region [chemical binding]; other site 418127002340 ATP-binding site [chemical binding]; other site 418127002341 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 418127002342 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 418127002343 active site 418127002344 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 418127002345 30S subunit binding site; other site 418127002346 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 418127002347 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 418127002348 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 418127002349 nucleotide binding region [chemical binding]; other site 418127002350 ATP-binding site [chemical binding]; other site 418127002351 SEC-C motif; Region: SEC-C; pfam02810 418127002352 peptide chain release factor 2; Provisional; Region: PRK06746 418127002353 This domain is found in peptide chain release factors; Region: PCRF; smart00937 418127002354 RF-1 domain; Region: RF-1; pfam00472 418127002355 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 418127002356 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 418127002357 Surface antigen [General function prediction only]; Region: COG3942 418127002358 CHAP domain; Region: CHAP; pfam05257 418127002359 HD domain; Region: HD_3; cl17350 418127002360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 418127002361 excinuclease ABC subunit B; Provisional; Region: PRK05298 418127002362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127002363 ATP binding site [chemical binding]; other site 418127002364 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127002365 nucleotide binding region [chemical binding]; other site 418127002366 ATP-binding site [chemical binding]; other site 418127002367 Ultra-violet resistance protein B; Region: UvrB; pfam12344 418127002368 UvrB/uvrC motif; Region: UVR; pfam02151 418127002369 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 418127002370 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 418127002371 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 418127002372 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 418127002373 HPr kinase/phosphorylase; Provisional; Region: PRK05428 418127002374 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 418127002375 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 418127002376 Hpr binding site; other site 418127002377 active site 418127002378 homohexamer subunit interaction site [polypeptide binding]; other site 418127002379 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 418127002380 putative acyl transferase; Provisional; Region: PRK10191 418127002381 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 418127002382 trimer interface [polypeptide binding]; other site 418127002383 active site 418127002384 substrate binding site [chemical binding]; other site 418127002385 CoA binding site [chemical binding]; other site 418127002386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 418127002387 binding surface 418127002388 TPR motif; other site 418127002389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 418127002390 TPR motif; other site 418127002391 binding surface 418127002392 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 418127002393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 418127002394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 418127002395 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 418127002396 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 418127002397 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 418127002398 phosphate binding site [ion binding]; other site 418127002399 dimer interface [polypeptide binding]; other site 418127002400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 418127002401 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 418127002402 Clp protease; Region: CLP_protease; pfam00574 418127002403 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 418127002404 oligomer interface [polypeptide binding]; other site 418127002405 active site residues [active] 418127002406 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 418127002407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127002408 NAD(P) binding site [chemical binding]; other site 418127002409 active site 418127002410 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 418127002411 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 418127002412 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 418127002413 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 418127002414 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 418127002415 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 418127002416 Phosphoglycerate kinase; Region: PGK; pfam00162 418127002417 substrate binding site [chemical binding]; other site 418127002418 hinge regions; other site 418127002419 ADP binding site [chemical binding]; other site 418127002420 catalytic site [active] 418127002421 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 418127002422 triosephosphate isomerase; Provisional; Region: PRK14565 418127002423 substrate binding site [chemical binding]; other site 418127002424 dimer interface [polypeptide binding]; other site 418127002425 catalytic triad [active] 418127002426 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 418127002427 phosphoglyceromutase; Provisional; Region: PRK05434 418127002428 enolase; Provisional; Region: eno; PRK00077 418127002429 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 418127002430 dimer interface [polypeptide binding]; other site 418127002431 metal binding site [ion binding]; metal-binding site 418127002432 substrate binding pocket [chemical binding]; other site 418127002433 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 418127002434 Esterase/lipase [General function prediction only]; Region: COG1647 418127002435 ribonuclease R; Region: RNase_R; TIGR02063 418127002436 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 418127002437 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 418127002438 RNB domain; Region: RNB; pfam00773 418127002439 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 418127002440 RNA binding site [nucleotide binding]; other site 418127002441 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 418127002442 SmpB-tmRNA interface; other site 418127002443 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 418127002444 Int/Topo IB signature motif; other site 418127002445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 418127002446 sequence-specific DNA binding site [nucleotide binding]; other site 418127002447 salt bridge; other site 418127002448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 418127002449 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127002450 salt bridge; other site 418127002451 non-specific DNA binding site [nucleotide binding]; other site 418127002452 sequence-specific DNA binding site [nucleotide binding]; other site 418127002453 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 418127002454 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 418127002455 Virulence-associated protein E; Region: VirE; pfam05272 418127002456 hydrolase, hydrolyzing O-glycosyl compounds; Region: PLN02219; cl14104 418127002457 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 418127002458 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 418127002459 Abi-like protein; Region: Abi_2; pfam07751 418127002460 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 418127002461 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 418127002462 putative ligand binding residues [chemical binding]; other site 418127002463 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 418127002464 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 418127002465 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127002466 Coenzyme A binding pocket [chemical binding]; other site 418127002467 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 418127002468 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 418127002469 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 418127002470 Staphylococcal nuclease homologues; Region: SNc; smart00318 418127002471 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 418127002472 Catalytic site; other site 418127002473 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 418127002474 DNA-binding site [nucleotide binding]; DNA binding site 418127002475 RNA-binding motif; other site 418127002476 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 418127002477 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 418127002478 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 418127002479 catalytic core [active] 418127002480 Lysine efflux permease [General function prediction only]; Region: COG1279 418127002481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 418127002482 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 418127002483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 418127002484 similar to hypothetical protein 418127002485 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 418127002486 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 418127002487 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 418127002488 active site 418127002489 catalytic residue [active] 418127002490 dimer interface [polypeptide binding]; other site 418127002491 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 418127002492 putative FMN binding site [chemical binding]; other site 418127002493 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 418127002494 catalytic residues [active] 418127002495 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 418127002496 ArsC family; Region: ArsC; pfam03960 418127002497 putative ArsC-like catalytic residues; other site 418127002498 putative TRX-like catalytic residues [active] 418127002499 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 418127002500 lipoyl attachment site [posttranslational modification]; other site 418127002501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 418127002502 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 418127002503 putative active site [active] 418127002504 putative metal binding site [ion binding]; other site 418127002505 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 418127002506 catalytic residues [active] 418127002507 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 418127002508 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 418127002509 Walker A/P-loop; other site 418127002510 ATP binding site [chemical binding]; other site 418127002511 Q-loop/lid; other site 418127002512 ABC transporter signature motif; other site 418127002513 Walker B; other site 418127002514 D-loop; other site 418127002515 H-loop/switch region; other site 418127002516 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 418127002517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127002518 dimer interface [polypeptide binding]; other site 418127002519 conserved gate region; other site 418127002520 ABC-ATPase subunit interface; other site 418127002521 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 418127002522 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 418127002523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 418127002524 Predicted membrane protein [Function unknown]; Region: COG2035 418127002525 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 418127002526 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 418127002527 Walker A/P-loop; other site 418127002528 ATP binding site [chemical binding]; other site 418127002529 Q-loop/lid; other site 418127002530 ABC transporter signature motif; other site 418127002531 Walker B; other site 418127002532 D-loop; other site 418127002533 H-loop/switch region; other site 418127002534 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 418127002535 FeS assembly protein SufD; Region: sufD; TIGR01981 418127002536 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 418127002537 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 418127002538 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127002539 catalytic residue [active] 418127002540 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 418127002541 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 418127002542 trimerization site [polypeptide binding]; other site 418127002543 active site 418127002544 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 418127002545 FeS assembly protein SufB; Region: sufB; TIGR01980 418127002546 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 418127002547 active site 418127002548 DNA binding site [nucleotide binding] 418127002549 Int/Topo IB signature motif; other site 418127002550 Domain of unknown function (DUF955); Region: DUF955; pfam06114 418127002551 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 418127002552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127002553 non-specific DNA binding site [nucleotide binding]; other site 418127002554 salt bridge; other site 418127002555 sequence-specific DNA binding site [nucleotide binding]; other site 418127002556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127002557 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 418127002558 non-specific DNA binding site [nucleotide binding]; other site 418127002559 salt bridge; other site 418127002560 sequence-specific DNA binding site [nucleotide binding]; other site 418127002561 Prophage antirepressor [Transcription]; Region: COG3617 418127002562 BRO family, N-terminal domain; Region: Bro-N; smart01040 418127002563 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 418127002564 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 418127002565 Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656 418127002566 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 418127002567 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 418127002568 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 418127002569 dimer interface [polypeptide binding]; other site 418127002570 ssDNA binding site [nucleotide binding]; other site 418127002571 tetramer (dimer of dimers) interface [polypeptide binding]; other site 418127002572 NUMOD4 motif; Region: NUMOD4; pfam07463 418127002573 HNH endonuclease; Region: HNH_3; pfam13392 418127002574 Protein of unknown function (DUF968); Region: DUF968; pfam06147 418127002575 Helix-turn-helix domain; Region: HTH_36; pfam13730 418127002576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127002577 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 418127002578 Walker A motif; other site 418127002579 ATP binding site [chemical binding]; other site 418127002580 Walker B motif; other site 418127002581 arginine finger; other site 418127002582 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 418127002583 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 418127002584 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 418127002585 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 418127002586 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 418127002587 dUTPase; Region: dUTPase_2; pfam08761 418127002588 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 418127002589 active site 418127002590 homodimer interface [polypeptide binding]; other site 418127002591 metal binding site [ion binding]; metal-binding site 418127002592 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 418127002593 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 418127002594 Transcriptional activator RinB; Region: RinB; pfam06116 418127002595 similar to hypothetical protein 418127002596 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 418127002597 Terminase small subunit; Region: Terminase_2; pfam03592 418127002598 phage terminase, large subunit, PBSX family; Region: phage_term_2; TIGR01547 418127002599 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 418127002600 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 418127002601 phage putative head morphogenesis protein, SPP1 gp7 family; Region: phageSPP1_gp7; TIGR01641 418127002602 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 418127002603 Phage capsid family; Region: Phage_capsid; pfam05065 418127002604 Phage capsid family; Region: Phage_capsid; pfam05065 418127002605 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 418127002606 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 418127002607 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 418127002608 Phage protein; Region: DUF3647; pfam12363 418127002609 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 418127002610 Phage-related protein [Function unknown]; Region: COG5412 418127002611 membrane protein P6; Region: PHA01399 418127002612 Phage tail protein; Region: Sipho_tail; pfam05709 418127002613 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 418127002614 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 418127002615 active site 418127002616 catalytic triad [active] 418127002617 oxyanion hole [active] 418127002618 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 418127002619 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 418127002620 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 418127002621 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 418127002622 CHAP domain; Region: CHAP; pfam05257 418127002623 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 418127002624 Lysozyme subfamily 2; Region: LYZ2; smart00047 418127002625 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 418127002626 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 418127002627 Phage tail repeat like; Region: PTR; pfam12789 418127002628 Bacteriophage holin; Region: Phage_holin_1; pfam04531 418127002629 CHAP domain; Region: CHAP; pfam05257 418127002630 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 418127002631 amidase catalytic site [active] 418127002632 Zn binding residues [ion binding]; other site 418127002633 substrate binding site [chemical binding]; other site 418127002634 Bacterial SH3 domain; Region: SH3_5; pfam08460 418127002635 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 418127002636 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 418127002637 Domain of unknown function DUF21; Region: DUF21; pfam01595 418127002638 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 418127002639 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 418127002640 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 418127002641 FMN binding site [chemical binding]; other site 418127002642 substrate binding site [chemical binding]; other site 418127002643 putative catalytic residue [active] 418127002644 Uncharacterized conserved protein [Function unknown]; Region: COG1801 418127002645 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 418127002646 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 418127002647 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 418127002648 active site 418127002649 metal binding site [ion binding]; metal-binding site 418127002650 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 418127002651 lipoyl synthase; Provisional; Region: PRK05481 418127002652 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 418127002653 FeS/SAM binding site; other site 418127002654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 418127002655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127002656 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127002657 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 418127002658 Uncharacterized conserved protein [Function unknown]; Region: COG2445 418127002659 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 418127002660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127002661 active site 418127002662 motif I; other site 418127002663 motif II; other site 418127002664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127002665 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 418127002666 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 418127002667 dimerization interface [polypeptide binding]; other site 418127002668 ligand binding site [chemical binding]; other site 418127002669 NADP binding site [chemical binding]; other site 418127002670 catalytic site [active] 418127002671 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 418127002672 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 418127002673 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 418127002674 acyl-activating enzyme (AAE) consensus motif; other site 418127002675 AMP binding site [chemical binding]; other site 418127002676 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 418127002677 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 418127002678 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 418127002679 DltD N-terminal region; Region: DltD_N; pfam04915 418127002680 DltD central region; Region: DltD_M; pfam04918 418127002681 DltD C-terminal region; Region: DltD_C; pfam04914 418127002682 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 418127002683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 418127002684 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 418127002685 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 418127002686 hypothetical protein; Provisional; Region: PRK13669 418127002687 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 418127002688 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 418127002689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 418127002690 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 418127002691 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 418127002692 interface (dimer of trimers) [polypeptide binding]; other site 418127002693 Substrate-binding/catalytic site; other site 418127002694 Zn-binding sites [ion binding]; other site 418127002695 Predicted permease [General function prediction only]; Region: COG2056 418127002696 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 418127002697 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 418127002698 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 418127002699 CoenzymeA binding site [chemical binding]; other site 418127002700 subunit interaction site [polypeptide binding]; other site 418127002701 PHB binding site; other site 418127002702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 418127002703 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 418127002704 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 418127002705 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 418127002706 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 418127002707 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 418127002708 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 418127002709 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 418127002710 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 418127002711 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 418127002712 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 418127002713 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 418127002714 Kinase associated protein B; Region: KapB; pfam08810 418127002715 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 418127002716 active site 418127002717 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 418127002718 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 418127002719 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 418127002720 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 418127002721 putative active site [active] 418127002722 putative FMN binding site [chemical binding]; other site 418127002723 putative substrate binding site [chemical binding]; other site 418127002724 putative catalytic residue [active] 418127002725 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 418127002726 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 418127002727 inhibitor-cofactor binding pocket; inhibition site 418127002728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127002729 catalytic residue [active] 418127002730 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 418127002731 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 418127002732 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 418127002733 NAD(P) binding site [chemical binding]; other site 418127002734 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 418127002735 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 418127002736 active site 418127002737 catalytic site [active] 418127002738 metal binding site [ion binding]; metal-binding site 418127002739 argininosuccinate lyase; Provisional; Region: PRK00855 418127002740 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 418127002741 active sites [active] 418127002742 tetramer interface [polypeptide binding]; other site 418127002743 argininosuccinate synthase; Provisional; Region: PRK13820 418127002744 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 418127002745 ANP binding site [chemical binding]; other site 418127002746 Substrate Binding Site II [chemical binding]; other site 418127002747 Substrate Binding Site I [chemical binding]; other site 418127002748 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 418127002749 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 418127002750 active site 418127002751 dimer interface [polypeptide binding]; other site 418127002752 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 418127002753 dimer interface [polypeptide binding]; other site 418127002754 active site 418127002755 Uncharacterized conserved protein [Function unknown]; Region: COG0398 418127002756 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 418127002757 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 418127002758 Catalytic site [active] 418127002759 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 418127002760 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 418127002761 Catalytic site [active] 418127002762 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 418127002763 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 418127002764 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 418127002765 Part of AAA domain; Region: AAA_19; pfam13245 418127002766 Family description; Region: UvrD_C_2; pfam13538 418127002767 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 418127002768 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 418127002769 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 418127002770 hypothetical protein; Provisional; Region: PRK13673 418127002771 coenzyme A disulfide reductase; Provisional; Region: PRK13512 418127002772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 418127002773 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 418127002774 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 418127002775 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 418127002776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127002777 active site 418127002778 motif I; other site 418127002779 motif II; other site 418127002780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127002781 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 418127002782 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 418127002783 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 418127002784 catalytic triad [active] 418127002785 catalytic triad [active] 418127002786 oxyanion hole [active] 418127002787 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 418127002788 Clp amino terminal domain; Region: Clp_N; pfam02861 418127002789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127002790 Walker A motif; other site 418127002791 ATP binding site [chemical binding]; other site 418127002792 Walker B motif; other site 418127002793 arginine finger; other site 418127002794 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 418127002795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127002796 Walker A motif; other site 418127002797 ATP binding site [chemical binding]; other site 418127002798 Walker B motif; other site 418127002799 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 418127002800 Transcriptional regulator [Transcription]; Region: LysR; COG0583 418127002801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 418127002802 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 418127002803 dimerization interface [polypeptide binding]; other site 418127002804 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 418127002805 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 418127002806 active site 418127002807 catalytic residues [active] 418127002808 metal binding site [ion binding]; metal-binding site 418127002809 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 418127002810 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 418127002811 substrate binding site [chemical binding]; other site 418127002812 MAP domain; Region: MAP; pfam03642 418127002813 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 418127002814 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 418127002815 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 418127002816 dimer interface [polypeptide binding]; other site 418127002817 active site 418127002818 CoA binding pocket [chemical binding]; other site 418127002819 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 418127002820 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 418127002821 dimer interface [polypeptide binding]; other site 418127002822 active site 418127002823 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 418127002824 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 418127002825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127002826 dimer interface [polypeptide binding]; other site 418127002827 conserved gate region; other site 418127002828 putative PBP binding loops; other site 418127002829 ABC-ATPase subunit interface; other site 418127002830 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 418127002831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127002832 dimer interface [polypeptide binding]; other site 418127002833 conserved gate region; other site 418127002834 putative PBP binding loops; other site 418127002835 ABC-ATPase subunit interface; other site 418127002836 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 418127002837 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 418127002838 Walker A/P-loop; other site 418127002839 ATP binding site [chemical binding]; other site 418127002840 Q-loop/lid; other site 418127002841 ABC transporter signature motif; other site 418127002842 Walker B; other site 418127002843 D-loop; other site 418127002844 H-loop/switch region; other site 418127002845 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 418127002846 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 418127002847 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 418127002848 Walker A/P-loop; other site 418127002849 ATP binding site [chemical binding]; other site 418127002850 Q-loop/lid; other site 418127002851 ABC transporter signature motif; other site 418127002852 Walker B; other site 418127002853 D-loop; other site 418127002854 H-loop/switch region; other site 418127002855 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 418127002856 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 418127002857 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 418127002858 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 418127002859 peptide binding site [polypeptide binding]; other site 418127002860 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 418127002861 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 418127002862 peptide binding site [polypeptide binding]; other site 418127002863 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 418127002864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 418127002865 Walker A/P-loop; other site 418127002866 ATP binding site [chemical binding]; other site 418127002867 Q-loop/lid; other site 418127002868 ABC transporter signature motif; other site 418127002869 Walker B; other site 418127002870 D-loop; other site 418127002871 H-loop/switch region; other site 418127002872 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 418127002873 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 418127002874 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 418127002875 Walker A/P-loop; other site 418127002876 ATP binding site [chemical binding]; other site 418127002877 Q-loop/lid; other site 418127002878 ABC transporter signature motif; other site 418127002879 Walker B; other site 418127002880 D-loop; other site 418127002881 H-loop/switch region; other site 418127002882 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 418127002883 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 418127002884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127002885 dimer interface [polypeptide binding]; other site 418127002886 conserved gate region; other site 418127002887 putative PBP binding loops; other site 418127002888 ABC-ATPase subunit interface; other site 418127002889 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 418127002890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127002891 dimer interface [polypeptide binding]; other site 418127002892 conserved gate region; other site 418127002893 putative PBP binding loops; other site 418127002894 ABC-ATPase subunit interface; other site 418127002895 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 418127002896 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 418127002897 active site 418127002898 HIGH motif; other site 418127002899 dimer interface [polypeptide binding]; other site 418127002900 KMSKS motif; other site 418127002901 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 418127002902 ArsC family; Region: ArsC; pfam03960 418127002903 putative catalytic residues [active] 418127002904 thiol/disulfide switch; other site 418127002905 adaptor protein; Provisional; Region: PRK02315 418127002906 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 418127002907 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 418127002908 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 418127002909 active site 418127002910 Zn binding site [ion binding]; other site 418127002911 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 418127002912 Thioredoxin; Region: Thioredoxin_5; pfam13743 418127002913 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 418127002914 apolar tunnel; other site 418127002915 heme binding site [chemical binding]; other site 418127002916 dimerization interface [polypeptide binding]; other site 418127002917 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 418127002918 putative active site [active] 418127002919 putative metal binding residues [ion binding]; other site 418127002920 signature motif; other site 418127002921 putative triphosphate binding site [ion binding]; other site 418127002922 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 418127002923 synthetase active site [active] 418127002924 NTP binding site [chemical binding]; other site 418127002925 metal binding site [ion binding]; metal-binding site 418127002926 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 418127002927 ATP-NAD kinase; Region: NAD_kinase; pfam01513 418127002928 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 418127002929 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 418127002930 active site 418127002931 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 418127002932 MgtE intracellular N domain; Region: MgtE_N; smart00924 418127002933 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 418127002934 Divalent cation transporter; Region: MgtE; pfam01769 418127002935 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 418127002936 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 418127002937 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 418127002938 TrkA-N domain; Region: TrkA_N; pfam02254 418127002939 TrkA-C domain; Region: TrkA_C; pfam02080 418127002940 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 418127002941 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 418127002942 NAD binding site [chemical binding]; other site 418127002943 homotetramer interface [polypeptide binding]; other site 418127002944 homodimer interface [polypeptide binding]; other site 418127002945 substrate binding site [chemical binding]; other site 418127002946 active site 418127002947 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 418127002948 Domain of unknown function DUF20; Region: UPF0118; pfam01594 418127002949 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 418127002950 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 418127002951 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 418127002952 Putative esterase; Region: Esterase; pfam00756 418127002953 hypothetical protein; Provisional; Region: PRK13679 418127002954 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 418127002955 Major Facilitator Superfamily; Region: MFS_1; pfam07690 418127002956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127002957 putative substrate translocation pore; other site 418127002958 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 418127002959 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 418127002960 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 418127002961 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 418127002962 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 418127002963 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 418127002964 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 418127002965 YueH-like protein; Region: YueH; pfam14166 418127002966 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 418127002967 G4 box; other site 418127002968 G5 box; other site 418127002969 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 418127002970 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 418127002971 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 418127002972 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 418127002973 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 418127002974 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 418127002975 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 418127002976 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 418127002977 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 418127002978 active site 418127002979 metal binding site [ion binding]; metal-binding site 418127002980 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 418127002981 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 418127002982 IDEAL domain; Region: IDEAL; pfam08858 418127002983 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 418127002984 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 418127002985 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 418127002986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 418127002987 CAAX protease self-immunity; Region: Abi; pfam02517 418127002988 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 418127002989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 418127002990 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 418127002991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 418127002992 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 418127002993 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 418127002994 Walker A/P-loop; other site 418127002995 ATP binding site [chemical binding]; other site 418127002996 Q-loop/lid; other site 418127002997 ABC transporter signature motif; other site 418127002998 Walker B; other site 418127002999 D-loop; other site 418127003000 H-loop/switch region; other site 418127003001 Predicted membrane protein [Function unknown]; Region: COG2259 418127003002 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 418127003003 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 418127003004 siderophore binding site; other site 418127003005 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 418127003006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127003007 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 418127003008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 418127003009 Coenzyme A binding pocket [chemical binding]; other site 418127003010 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 418127003011 UbiA prenyltransferase family; Region: UbiA; pfam01040 418127003012 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 418127003013 isochorismate synthases; Region: isochor_syn; TIGR00543 418127003014 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 418127003015 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 418127003016 dimer interface [polypeptide binding]; other site 418127003017 tetramer interface [polypeptide binding]; other site 418127003018 PYR/PP interface [polypeptide binding]; other site 418127003019 TPP binding site [chemical binding]; other site 418127003020 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 418127003021 TPP-binding site; other site 418127003022 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 418127003023 PGAP1-like protein; Region: PGAP1; pfam07819 418127003024 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 418127003025 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 418127003026 substrate binding site [chemical binding]; other site 418127003027 oxyanion hole (OAH) forming residues; other site 418127003028 trimer interface [polypeptide binding]; other site 418127003029 Staphostatin B; Region: Staphostatin_B; pfam09023 418127003030 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 418127003031 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 418127003032 aminotransferase A; Validated; Region: PRK07683 418127003033 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 418127003034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127003035 homodimer interface [polypeptide binding]; other site 418127003036 catalytic residue [active] 418127003037 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 418127003038 Acyltransferase family; Region: Acyl_transf_3; pfam01757 418127003039 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 418127003040 MarR family; Region: MarR; pfam01047 418127003041 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 418127003042 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 418127003043 amidase catalytic site [active] 418127003044 Zn binding residues [ion binding]; other site 418127003045 substrate binding site [chemical binding]; other site 418127003046 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 418127003047 Lysozyme subfamily 2; Region: LYZ2; smart00047 418127003048 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127003049 Coenzyme A binding pocket [chemical binding]; other site 418127003050 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 418127003051 Transcriptional regulator [Transcription]; Region: LytR; COG1316 418127003052 Beta-lactamase; Region: Beta-lactamase; pfam00144 418127003053 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 418127003054 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 418127003055 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 418127003056 Subunit I/III interface [polypeptide binding]; other site 418127003057 Subunit III/IV interface [polypeptide binding]; other site 418127003058 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 418127003059 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 418127003060 D-pathway; other site 418127003061 Putative ubiquinol binding site [chemical binding]; other site 418127003062 Low-spin heme (heme b) binding site [chemical binding]; other site 418127003063 Putative water exit pathway; other site 418127003064 Binuclear center (heme o3/CuB) [ion binding]; other site 418127003065 K-pathway; other site 418127003066 Putative proton exit pathway; other site 418127003067 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 418127003068 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 418127003069 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 418127003070 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 418127003071 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 418127003072 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 418127003073 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 418127003074 homodimer interface [polypeptide binding]; other site 418127003075 NADP binding site [chemical binding]; other site 418127003076 substrate binding site [chemical binding]; other site 418127003077 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 418127003078 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 418127003079 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 418127003080 NAD binding site [chemical binding]; other site 418127003081 ATP-grasp domain; Region: ATP-grasp; pfam02222 418127003082 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 418127003083 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 418127003084 ATP binding site [chemical binding]; other site 418127003085 active site 418127003086 substrate binding site [chemical binding]; other site 418127003087 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 418127003088 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 418127003089 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 418127003090 putative active site [active] 418127003091 catalytic triad [active] 418127003092 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 418127003093 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 418127003094 dimerization interface [polypeptide binding]; other site 418127003095 ATP binding site [chemical binding]; other site 418127003096 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 418127003097 dimerization interface [polypeptide binding]; other site 418127003098 ATP binding site [chemical binding]; other site 418127003099 amidophosphoribosyltransferase; Provisional; Region: PRK07272 418127003100 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 418127003101 active site 418127003102 tetramer interface [polypeptide binding]; other site 418127003103 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 418127003104 active site 418127003105 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 418127003106 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 418127003107 dimerization interface [polypeptide binding]; other site 418127003108 putative ATP binding site [chemical binding]; other site 418127003109 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 418127003110 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 418127003111 active site 418127003112 substrate binding site [chemical binding]; other site 418127003113 cosubstrate binding site; other site 418127003114 catalytic site [active] 418127003115 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 418127003116 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 418127003117 purine monophosphate binding site [chemical binding]; other site 418127003118 dimer interface [polypeptide binding]; other site 418127003119 putative catalytic residues [active] 418127003120 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 418127003121 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 418127003122 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 418127003123 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 418127003124 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 418127003125 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 418127003126 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 418127003127 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 418127003128 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 418127003129 Walker A/P-loop; other site 418127003130 ATP binding site [chemical binding]; other site 418127003131 Q-loop/lid; other site 418127003132 ABC transporter signature motif; other site 418127003133 Walker B; other site 418127003134 D-loop; other site 418127003135 H-loop/switch region; other site 418127003136 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 418127003137 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 418127003138 Walker A/P-loop; other site 418127003139 ATP binding site [chemical binding]; other site 418127003140 Q-loop/lid; other site 418127003141 ABC transporter signature motif; other site 418127003142 Walker B; other site 418127003143 D-loop; other site 418127003144 H-loop/switch region; other site 418127003145 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 418127003146 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 418127003147 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 418127003148 putative RNA binding site [nucleotide binding]; other site 418127003149 Methyltransferase domain; Region: Methyltransf_26; pfam13659 418127003150 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 418127003151 dimerization domain swap beta strand [polypeptide binding]; other site 418127003152 regulatory protein interface [polypeptide binding]; other site 418127003153 active site 418127003154 regulatory phosphorylation site [posttranslational modification]; other site 418127003155 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 418127003156 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 418127003157 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 418127003158 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 418127003159 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 418127003160 catalytic residues [active] 418127003161 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 418127003162 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 418127003163 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 418127003164 TrkA-N domain; Region: TrkA_N; pfam02254 418127003165 TrkA-C domain; Region: TrkA_C; pfam02080 418127003166 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 418127003167 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 418127003168 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 418127003169 hypothetical protein; Provisional; Region: PRK13667 418127003170 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 418127003171 active site 418127003172 catalytic residues [active] 418127003173 metal binding site [ion binding]; metal-binding site 418127003174 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 418127003175 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 418127003176 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 418127003177 TPP-binding site [chemical binding]; other site 418127003178 tetramer interface [polypeptide binding]; other site 418127003179 heterodimer interface [polypeptide binding]; other site 418127003180 phosphorylation loop region [posttranslational modification] 418127003181 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 418127003182 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 418127003183 alpha subunit interface [polypeptide binding]; other site 418127003184 TPP binding site [chemical binding]; other site 418127003185 heterodimer interface [polypeptide binding]; other site 418127003186 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 418127003187 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 418127003188 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 418127003189 E3 interaction surface; other site 418127003190 lipoyl attachment site [posttranslational modification]; other site 418127003191 e3 binding domain; Region: E3_binding; pfam02817 418127003192 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 418127003193 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 418127003194 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 418127003195 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 418127003196 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 418127003197 hypothetical protein; Provisional; Region: PRK04387 418127003198 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 418127003199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127003200 non-specific DNA binding site [nucleotide binding]; other site 418127003201 salt bridge; other site 418127003202 sequence-specific DNA binding site [nucleotide binding]; other site 418127003203 Cupin domain; Region: Cupin_2; pfam07883 418127003204 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 418127003205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 418127003206 Walker A/P-loop; other site 418127003207 ATP binding site [chemical binding]; other site 418127003208 Q-loop/lid; other site 418127003209 ABC transporter signature motif; other site 418127003210 Walker B; other site 418127003211 D-loop; other site 418127003212 H-loop/switch region; other site 418127003213 TOBE domain; Region: TOBE_2; pfam08402 418127003214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127003215 putative PBP binding loops; other site 418127003216 dimer interface [polypeptide binding]; other site 418127003217 ABC-ATPase subunit interface; other site 418127003218 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 418127003219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127003220 dimer interface [polypeptide binding]; other site 418127003221 conserved gate region; other site 418127003222 putative PBP binding loops; other site 418127003223 ABC-ATPase subunit interface; other site 418127003224 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 418127003225 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 418127003226 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 418127003227 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 418127003228 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 418127003229 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 418127003230 manganese transport protein MntH; Reviewed; Region: PRK00701 418127003231 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 418127003232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 418127003233 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 418127003234 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 418127003235 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 418127003236 active site 418127003237 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 418127003238 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 418127003239 G1 box; other site 418127003240 putative GEF interaction site [polypeptide binding]; other site 418127003241 GTP/Mg2+ binding site [chemical binding]; other site 418127003242 Switch I region; other site 418127003243 G2 box; other site 418127003244 G3 box; other site 418127003245 Switch II region; other site 418127003246 G4 box; other site 418127003247 G5 box; other site 418127003248 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 418127003249 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 418127003250 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 418127003251 hypothetical protein; Provisional; Region: PRK13666 418127003252 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 418127003253 pyruvate carboxylase; Reviewed; Region: PRK12999 418127003254 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 418127003255 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 418127003256 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 418127003257 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 418127003258 active site 418127003259 catalytic residues [active] 418127003260 metal binding site [ion binding]; metal-binding site 418127003261 homodimer binding site [polypeptide binding]; other site 418127003262 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 418127003263 carboxyltransferase (CT) interaction site; other site 418127003264 biotinylation site [posttranslational modification]; other site 418127003265 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 418127003266 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 418127003267 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 418127003268 UbiA prenyltransferase family; Region: UbiA; pfam01040 418127003269 Predicted membrane protein [Function unknown]; Region: COG2322 418127003270 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 418127003271 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 418127003272 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 418127003273 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 418127003274 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 418127003275 putative active site [active] 418127003276 catalytic site [active] 418127003277 putative metal binding site [ion binding]; other site 418127003278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 418127003279 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 418127003280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127003281 S-adenosylmethionine binding site [chemical binding]; other site 418127003282 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 418127003283 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 418127003284 active site 418127003285 (T/H)XGH motif; other site 418127003286 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 418127003287 hypothetical protein; Provisional; Region: PRK13670 418127003288 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 418127003289 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 418127003290 heme uptake protein IsdB; Region: IsdB; TIGR03657 418127003291 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 418127003292 NEAr Transporter domain; Region: NEAT; smart00725 418127003293 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 418127003294 heme-binding site [chemical binding]; other site 418127003295 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 418127003296 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 418127003297 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 418127003298 heme-binding site [chemical binding]; other site 418127003299 heme uptake protein IsdC; Region: IsdC; TIGR03656 418127003300 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 418127003301 heme-binding site [chemical binding]; other site 418127003302 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 418127003303 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 418127003304 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 418127003305 intersubunit interface [polypeptide binding]; other site 418127003306 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 418127003307 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 418127003308 ABC-ATPase subunit interface; other site 418127003309 dimer interface [polypeptide binding]; other site 418127003310 putative PBP binding regions; other site 418127003311 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 418127003312 active site 418127003313 catalytic site [active] 418127003314 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 418127003315 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 418127003316 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 418127003317 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 418127003318 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 418127003319 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 418127003320 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 418127003321 dimer interface [polypeptide binding]; other site 418127003322 motif 1; other site 418127003323 active site 418127003324 motif 2; other site 418127003325 motif 3; other site 418127003326 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 418127003327 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 418127003328 putative tRNA-binding site [nucleotide binding]; other site 418127003329 B3/4 domain; Region: B3_4; pfam03483 418127003330 tRNA synthetase B5 domain; Region: B5; smart00874 418127003331 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 418127003332 dimer interface [polypeptide binding]; other site 418127003333 motif 1; other site 418127003334 motif 3; other site 418127003335 motif 2; other site 418127003336 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 418127003337 ribonuclease HIII; Provisional; Region: PRK00996 418127003338 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 418127003339 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 418127003340 RNA/DNA hybrid binding site [nucleotide binding]; other site 418127003341 active site 418127003342 Cell division protein ZapA; Region: ZapA; cl01146 418127003343 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 418127003344 Colicin V production protein; Region: Colicin_V; pfam02674 418127003345 hypothetical protein; Provisional; Region: PRK08609 418127003346 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 418127003347 active site 418127003348 primer binding site [nucleotide binding]; other site 418127003349 NTP binding site [chemical binding]; other site 418127003350 metal binding triad [ion binding]; metal-binding site 418127003351 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 418127003352 active site 418127003353 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 418127003354 MutS domain III; Region: MutS_III; pfam05192 418127003355 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 418127003356 Walker A/P-loop; other site 418127003357 ATP binding site [chemical binding]; other site 418127003358 Q-loop/lid; other site 418127003359 ABC transporter signature motif; other site 418127003360 Walker B; other site 418127003361 D-loop; other site 418127003362 H-loop/switch region; other site 418127003363 Smr domain; Region: Smr; pfam01713 418127003364 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 418127003365 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 418127003366 catalytic residues [active] 418127003367 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 418127003368 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 418127003369 GIY-YIG motif/motif A; other site 418127003370 active site 418127003371 catalytic site [active] 418127003372 putative DNA binding site [nucleotide binding]; other site 418127003373 metal binding site [ion binding]; metal-binding site 418127003374 UvrB/uvrC motif; Region: UVR; pfam02151 418127003375 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 418127003376 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 418127003377 putative Iron-sulfur protein interface [polypeptide binding]; other site 418127003378 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 418127003379 proximal heme binding site [chemical binding]; other site 418127003380 distal heme binding site [chemical binding]; other site 418127003381 putative dimer interface [polypeptide binding]; other site 418127003382 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 418127003383 L-aspartate oxidase; Provisional; Region: PRK06175 418127003384 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 418127003385 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 418127003386 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 418127003387 glutamate racemase; Provisional; Region: PRK00865 418127003388 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 418127003389 active site 418127003390 dimerization interface [polypeptide binding]; other site 418127003391 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 418127003392 active site 418127003393 metal binding site [ion binding]; metal-binding site 418127003394 homotetramer interface [polypeptide binding]; other site 418127003395 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 418127003396 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 418127003397 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 418127003398 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 418127003399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127003400 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127003401 beta-channel forming cytolysin; Region: hlyII; TIGR01002 418127003402 superantigen-like protein; Reviewed; Region: PRK13350 418127003403 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127003404 superantigen-like protein; Reviewed; Region: PRK13349 418127003405 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127003406 superantigen-like protein; Reviewed; Region: PRK13043 418127003407 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127003408 ornithine carbamoyltransferase; Provisional; Region: PRK04284 418127003409 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 418127003410 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 418127003411 carbamate kinase; Reviewed; Region: PRK12686 418127003412 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 418127003413 putative substrate binding site [chemical binding]; other site 418127003414 nucleotide binding site [chemical binding]; other site 418127003415 nucleotide binding site [chemical binding]; other site 418127003416 homodimer interface [polypeptide binding]; other site 418127003417 Predicted membrane protein [Function unknown]; Region: COG1288 418127003418 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 418127003419 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 418127003420 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 418127003421 gating phenylalanine in ion channel; other site 418127003422 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 418127003423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127003424 motif II; other site 418127003425 hypothetical protein; Provisional; Region: PRK13688 418127003426 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 418127003427 Coenzyme A binding pocket [chemical binding]; other site 418127003428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 418127003429 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 418127003430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 418127003431 MraZ protein; Region: MraZ; pfam02381 418127003432 MraZ protein; Region: MraZ; pfam02381 418127003433 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 418127003434 MraW methylase family; Region: Methyltransf_5; pfam01795 418127003435 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 418127003436 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 418127003437 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 418127003438 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 418127003439 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 418127003440 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 418127003441 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 418127003442 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 418127003443 Mg++ binding site [ion binding]; other site 418127003444 putative catalytic motif [active] 418127003445 putative substrate binding site [chemical binding]; other site 418127003446 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 418127003447 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 418127003448 NAD binding site [chemical binding]; other site 418127003449 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 418127003450 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 418127003451 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 418127003452 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 418127003453 Cell division protein FtsQ; Region: FtsQ; pfam03799 418127003454 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 418127003455 Cell division protein FtsA; Region: FtsA; smart00842 418127003456 Cell division protein FtsA; Region: FtsA; pfam14450 418127003457 cell division protein FtsZ; Validated; Region: PRK09330 418127003458 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 418127003459 nucleotide binding site [chemical binding]; other site 418127003460 SulA interaction site; other site 418127003461 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 418127003462 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 418127003463 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 418127003464 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 418127003465 catalytic residue [active] 418127003466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 418127003467 YGGT family; Region: YGGT; pfam02325 418127003468 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 418127003469 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 418127003470 RNA binding surface [nucleotide binding]; other site 418127003471 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 418127003472 DivIVA domain; Region: DivI1A_domain; TIGR03544 418127003473 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 418127003474 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 418127003475 HIGH motif; other site 418127003476 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 418127003477 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 418127003478 active site 418127003479 KMSKS motif; other site 418127003480 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 418127003481 tRNA binding surface [nucleotide binding]; other site 418127003482 anticodon binding site; other site 418127003483 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 418127003484 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 418127003485 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 418127003486 active site 418127003487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 418127003488 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 418127003489 lipoprotein signal peptidase; Provisional; Region: PRK14787 418127003490 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 418127003491 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 418127003492 RNA binding surface [nucleotide binding]; other site 418127003493 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 418127003494 active site 418127003495 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 418127003496 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 418127003497 uracil transporter; Provisional; Region: PRK10720 418127003498 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 418127003499 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 418127003500 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 418127003501 dihydroorotase; Validated; Region: pyrC; PRK09357 418127003502 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 418127003503 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 418127003504 active site 418127003505 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 418127003506 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 418127003507 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 418127003508 catalytic site [active] 418127003509 subunit interface [polypeptide binding]; other site 418127003510 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 418127003511 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 418127003512 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 418127003513 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 418127003514 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 418127003515 ATP-grasp domain; Region: ATP-grasp_4; cl17255 418127003516 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 418127003517 IMP binding site; other site 418127003518 dimer interface [polypeptide binding]; other site 418127003519 interdomain contacts; other site 418127003520 partial ornithine binding site; other site 418127003521 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 418127003522 active site 418127003523 dimer interface [polypeptide binding]; other site 418127003524 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 418127003525 active site 418127003526 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 418127003527 dimer interface [polypeptide binding]; other site 418127003528 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 418127003529 Domain of unknown function (DUF814); Region: DUF814; pfam05670 418127003530 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 418127003531 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 418127003532 catalytic site [active] 418127003533 G-X2-G-X-G-K; other site 418127003534 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 418127003535 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 418127003536 Flavoprotein; Region: Flavoprotein; pfam02441 418127003537 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 418127003538 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 418127003539 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127003540 ATP binding site [chemical binding]; other site 418127003541 putative Mg++ binding site [ion binding]; other site 418127003542 helicase superfamily c-terminal domain; Region: HELICc; smart00490 418127003543 nucleotide binding region [chemical binding]; other site 418127003544 ATP-binding site [chemical binding]; other site 418127003545 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 418127003546 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 418127003547 active site 418127003548 catalytic residues [active] 418127003549 metal binding site [ion binding]; metal-binding site 418127003550 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 418127003551 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 418127003552 putative active site [active] 418127003553 substrate binding site [chemical binding]; other site 418127003554 putative cosubstrate binding site; other site 418127003555 catalytic site [active] 418127003556 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 418127003557 substrate binding site [chemical binding]; other site 418127003558 16S rRNA methyltransferase B; Provisional; Region: PRK14902 418127003559 NusB family; Region: NusB; pfam01029 418127003560 putative RNA binding site [nucleotide binding]; other site 418127003561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127003562 S-adenosylmethionine binding site [chemical binding]; other site 418127003563 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 418127003564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 418127003565 FeS/SAM binding site; other site 418127003566 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 418127003567 Protein phosphatase 2C; Region: PP2C; pfam00481 418127003568 active site 418127003569 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 418127003570 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 418127003571 active site 418127003572 ATP binding site [chemical binding]; other site 418127003573 substrate binding site [chemical binding]; other site 418127003574 activation loop (A-loop); other site 418127003575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 418127003576 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 418127003577 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 418127003578 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 418127003579 Predicted GTPases [General function prediction only]; Region: COG1162 418127003580 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 418127003581 RNA binding site [nucleotide binding]; other site 418127003582 homodimer interface [polypeptide binding]; other site 418127003583 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 418127003584 GTPase/Zn-binding domain interface [polypeptide binding]; other site 418127003585 GTP/Mg2+ binding site [chemical binding]; other site 418127003586 G4 box; other site 418127003587 G5 box; other site 418127003588 G1 box; other site 418127003589 Switch I region; other site 418127003590 G2 box; other site 418127003591 G3 box; other site 418127003592 Switch II region; other site 418127003593 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 418127003594 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 418127003595 substrate binding site [chemical binding]; other site 418127003596 hexamer interface [polypeptide binding]; other site 418127003597 metal binding site [ion binding]; metal-binding site 418127003598 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 418127003599 Thiamine pyrophosphokinase; Region: TPK; cd07995 418127003600 active site 418127003601 dimerization interface [polypeptide binding]; other site 418127003602 thiamine binding site [chemical binding]; other site 418127003603 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 418127003604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 418127003605 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 418127003606 DAK2 domain; Region: Dak2; pfam02734 418127003607 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 418127003608 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 418127003609 generic binding surface II; other site 418127003610 ssDNA binding site; other site 418127003611 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127003612 ATP binding site [chemical binding]; other site 418127003613 putative Mg++ binding site [ion binding]; other site 418127003614 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127003615 nucleotide binding region [chemical binding]; other site 418127003616 ATP-binding site [chemical binding]; other site 418127003617 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 418127003618 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 418127003619 active site 2 [active] 418127003620 active site 1 [active] 418127003621 putative phosphate acyltransferase; Provisional; Region: PRK05331 418127003622 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 418127003623 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 418127003624 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 418127003625 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 418127003626 NAD(P) binding site [chemical binding]; other site 418127003627 homotetramer interface [polypeptide binding]; other site 418127003628 homodimer interface [polypeptide binding]; other site 418127003629 active site 418127003630 acyl carrier protein; Provisional; Region: acpP; PRK00982 418127003631 ribonuclease III; Reviewed; Region: rnc; PRK00102 418127003632 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 418127003633 dimerization interface [polypeptide binding]; other site 418127003634 active site 418127003635 metal binding site [ion binding]; metal-binding site 418127003636 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 418127003637 dsRNA binding site [nucleotide binding]; other site 418127003638 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 418127003639 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 418127003640 Walker A/P-loop; other site 418127003641 ATP binding site [chemical binding]; other site 418127003642 Q-loop/lid; other site 418127003643 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 418127003644 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 418127003645 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 418127003646 ABC transporter signature motif; other site 418127003647 Walker B; other site 418127003648 D-loop; other site 418127003649 H-loop/switch region; other site 418127003650 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 418127003651 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 418127003652 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 418127003653 P loop; other site 418127003654 GTP binding site [chemical binding]; other site 418127003655 putative DNA-binding protein; Validated; Region: PRK00118 418127003656 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 418127003657 signal recognition particle protein; Provisional; Region: PRK10867 418127003658 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 418127003659 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 418127003660 P loop; other site 418127003661 GTP binding site [chemical binding]; other site 418127003662 Signal peptide binding domain; Region: SRP_SPB; pfam02978 418127003663 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 418127003664 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 418127003665 RimM N-terminal domain; Region: RimM; pfam01782 418127003666 PRC-barrel domain; Region: PRC; pfam05239 418127003667 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 418127003668 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 418127003669 Predicted membrane protein [Function unknown]; Region: COG4485 418127003670 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 418127003671 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 418127003672 GTP/Mg2+ binding site [chemical binding]; other site 418127003673 G4 box; other site 418127003674 G5 box; other site 418127003675 G1 box; other site 418127003676 Switch I region; other site 418127003677 G2 box; other site 418127003678 G3 box; other site 418127003679 Switch II region; other site 418127003680 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 418127003681 RNA/DNA hybrid binding site [nucleotide binding]; other site 418127003682 active site 418127003683 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 418127003684 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 418127003685 CoA-ligase; Region: Ligase_CoA; pfam00549 418127003686 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 418127003687 CoA binding domain; Region: CoA_binding; pfam02629 418127003688 CoA-ligase; Region: Ligase_CoA; pfam00549 418127003689 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 418127003690 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 418127003691 CHAP domain; Region: CHAP; pfam05257 418127003692 FemAB family; Region: FemAB; pfam02388 418127003693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 418127003694 DNA protecting protein DprA; Region: dprA; TIGR00732 418127003695 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 418127003696 DNA topoisomerase I; Validated; Region: PRK05582 418127003697 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 418127003698 active site 418127003699 interdomain interaction site; other site 418127003700 putative metal-binding site [ion binding]; other site 418127003701 nucleotide binding site [chemical binding]; other site 418127003702 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 418127003703 domain I; other site 418127003704 DNA binding groove [nucleotide binding] 418127003705 phosphate binding site [ion binding]; other site 418127003706 domain II; other site 418127003707 domain III; other site 418127003708 nucleotide binding site [chemical binding]; other site 418127003709 catalytic site [active] 418127003710 domain IV; other site 418127003711 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 418127003712 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 418127003713 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 418127003714 Glucose inhibited division protein A; Region: GIDA; pfam01134 418127003715 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 418127003716 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 418127003717 active site 418127003718 DNA binding site [nucleotide binding] 418127003719 Int/Topo IB signature motif; other site 418127003720 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 418127003721 active site 418127003722 HslU subunit interaction site [polypeptide binding]; other site 418127003723 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 418127003724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127003725 Walker A motif; other site 418127003726 ATP binding site [chemical binding]; other site 418127003727 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 418127003728 Walker B motif; other site 418127003729 arginine finger; other site 418127003730 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 418127003731 transcriptional repressor CodY; Validated; Region: PRK04158 418127003732 CodY GAF-like domain; Region: CodY; pfam06018 418127003733 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 418127003734 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 418127003735 rRNA interaction site [nucleotide binding]; other site 418127003736 S8 interaction site; other site 418127003737 putative laminin-1 binding site; other site 418127003738 elongation factor Ts; Provisional; Region: tsf; PRK09377 418127003739 UBA/TS-N domain; Region: UBA; pfam00627 418127003740 Elongation factor TS; Region: EF_TS; pfam00889 418127003741 Elongation factor TS; Region: EF_TS; pfam00889 418127003742 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 418127003743 putative nucleotide binding site [chemical binding]; other site 418127003744 uridine monophosphate binding site [chemical binding]; other site 418127003745 homohexameric interface [polypeptide binding]; other site 418127003746 ribosome recycling factor; Reviewed; Region: frr; PRK00083 418127003747 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 418127003748 hinge region; other site 418127003749 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 418127003750 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 418127003751 catalytic residue [active] 418127003752 putative FPP diphosphate binding site; other site 418127003753 putative FPP binding hydrophobic cleft; other site 418127003754 dimer interface [polypeptide binding]; other site 418127003755 putative IPP diphosphate binding site; other site 418127003756 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 418127003757 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 418127003758 RIP metalloprotease RseP; Region: TIGR00054 418127003759 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 418127003760 active site 418127003761 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 418127003762 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 418127003763 protein binding site [polypeptide binding]; other site 418127003764 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 418127003765 putative substrate binding region [chemical binding]; other site 418127003766 prolyl-tRNA synthetase; Provisional; Region: PRK09194 418127003767 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 418127003768 dimer interface [polypeptide binding]; other site 418127003769 motif 1; other site 418127003770 active site 418127003771 motif 2; other site 418127003772 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 418127003773 putative deacylase active site [active] 418127003774 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 418127003775 active site 418127003776 motif 3; other site 418127003777 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 418127003778 anticodon binding site; other site 418127003779 DNA polymerase III PolC; Validated; Region: polC; PRK00448 418127003780 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 418127003781 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 418127003782 generic binding surface II; other site 418127003783 generic binding surface I; other site 418127003784 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 418127003785 active site 418127003786 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 418127003787 active site 418127003788 catalytic site [active] 418127003789 substrate binding site [chemical binding]; other site 418127003790 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 418127003791 ribosome maturation protein RimP; Reviewed; Region: PRK00092 418127003792 Sm and related proteins; Region: Sm_like; cl00259 418127003793 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 418127003794 putative oligomer interface [polypeptide binding]; other site 418127003795 putative RNA binding site [nucleotide binding]; other site 418127003796 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 418127003797 NusA N-terminal domain; Region: NusA_N; pfam08529 418127003798 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 418127003799 RNA binding site [nucleotide binding]; other site 418127003800 homodimer interface [polypeptide binding]; other site 418127003801 NusA-like KH domain; Region: KH_5; pfam13184 418127003802 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 418127003803 G-X-X-G motif; other site 418127003804 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 418127003805 putative RNA binding cleft [nucleotide binding]; other site 418127003806 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 418127003807 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 418127003808 translation initiation factor IF-2; Region: IF-2; TIGR00487 418127003809 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 418127003810 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 418127003811 G1 box; other site 418127003812 putative GEF interaction site [polypeptide binding]; other site 418127003813 GTP/Mg2+ binding site [chemical binding]; other site 418127003814 Switch I region; other site 418127003815 G2 box; other site 418127003816 G3 box; other site 418127003817 Switch II region; other site 418127003818 G4 box; other site 418127003819 G5 box; other site 418127003820 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 418127003821 Translation-initiation factor 2; Region: IF-2; pfam11987 418127003822 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 418127003823 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 418127003824 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 418127003825 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 418127003826 RNA binding site [nucleotide binding]; other site 418127003827 active site 418127003828 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 418127003829 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 418127003830 active site 418127003831 Riboflavin kinase; Region: Flavokinase; smart00904 418127003832 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 418127003833 16S/18S rRNA binding site [nucleotide binding]; other site 418127003834 S13e-L30e interaction site [polypeptide binding]; other site 418127003835 25S rRNA binding site [nucleotide binding]; other site 418127003836 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 418127003837 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 418127003838 RNase E interface [polypeptide binding]; other site 418127003839 trimer interface [polypeptide binding]; other site 418127003840 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 418127003841 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 418127003842 RNase E interface [polypeptide binding]; other site 418127003843 trimer interface [polypeptide binding]; other site 418127003844 active site 418127003845 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 418127003846 putative nucleic acid binding region [nucleotide binding]; other site 418127003847 G-X-X-G motif; other site 418127003848 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 418127003849 RNA binding site [nucleotide binding]; other site 418127003850 domain interface; other site 418127003851 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 418127003852 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 418127003853 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 418127003854 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 418127003855 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 418127003856 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 418127003857 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 418127003858 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 418127003859 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 418127003860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 418127003861 DNA-binding site [nucleotide binding]; DNA binding site 418127003862 UTRA domain; Region: UTRA; pfam07702 418127003863 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 418127003864 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 418127003865 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 418127003866 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 418127003867 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 418127003868 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 418127003869 classical (c) SDRs; Region: SDR_c; cd05233 418127003870 NAD(P) binding site [chemical binding]; other site 418127003871 active site 418127003872 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 418127003873 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 418127003874 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 418127003875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127003876 non-specific DNA binding site [nucleotide binding]; other site 418127003877 salt bridge; other site 418127003878 sequence-specific DNA binding site [nucleotide binding]; other site 418127003879 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 418127003880 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 418127003881 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 418127003882 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 418127003883 putative MPT binding site; other site 418127003884 recombinase A; Provisional; Region: recA; PRK09354 418127003885 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 418127003886 hexamer interface [polypeptide binding]; other site 418127003887 Walker A motif; other site 418127003888 ATP binding site [chemical binding]; other site 418127003889 Walker B motif; other site 418127003890 phosphodiesterase; Provisional; Region: PRK12704 418127003891 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 418127003892 Zn2+ binding site [ion binding]; other site 418127003893 Mg2+ binding site [ion binding]; other site 418127003894 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 418127003895 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 418127003896 putative active site [active] 418127003897 metal binding site [ion binding]; metal-binding site 418127003898 homodimer binding site [polypeptide binding]; other site 418127003899 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 418127003900 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 418127003901 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 418127003902 dimer interface [polypeptide binding]; other site 418127003903 PYR/PP interface [polypeptide binding]; other site 418127003904 TPP binding site [chemical binding]; other site 418127003905 substrate binding site [chemical binding]; other site 418127003906 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 418127003907 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 418127003908 TPP-binding site [chemical binding]; other site 418127003909 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 418127003910 Uncharacterized conserved protein [Function unknown]; Region: COG0011 418127003911 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 418127003912 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 418127003913 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 418127003914 FeS/SAM binding site; other site 418127003915 TRAM domain; Region: TRAM; pfam01938 418127003916 Predicted membrane protein [Function unknown]; Region: COG4550 418127003917 Predicted membrane protein [Function unknown]; Region: COG4732 418127003918 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 418127003919 MutS domain I; Region: MutS_I; pfam01624 418127003920 MutS domain II; Region: MutS_II; pfam05188 418127003921 MutS domain III; Region: MutS_III; pfam05192 418127003922 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 418127003923 Walker A/P-loop; other site 418127003924 ATP binding site [chemical binding]; other site 418127003925 Q-loop/lid; other site 418127003926 ABC transporter signature motif; other site 418127003927 Walker B; other site 418127003928 D-loop; other site 418127003929 H-loop/switch region; other site 418127003930 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 418127003931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127003932 ATP binding site [chemical binding]; other site 418127003933 Mg2+ binding site [ion binding]; other site 418127003934 G-X-G motif; other site 418127003935 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 418127003936 ATP binding site [chemical binding]; other site 418127003937 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 418127003938 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 418127003939 similar to hypothetical protein 418127003940 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 418127003941 amphipathic channel; other site 418127003942 Asn-Pro-Ala signature motifs; other site 418127003943 glycerol kinase; Provisional; Region: glpK; PRK00047 418127003944 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 418127003945 N- and C-terminal domain interface [polypeptide binding]; other site 418127003946 active site 418127003947 MgATP binding site [chemical binding]; other site 418127003948 catalytic site [active] 418127003949 metal binding site [ion binding]; metal-binding site 418127003950 glycerol binding site [chemical binding]; other site 418127003951 homotetramer interface [polypeptide binding]; other site 418127003952 homodimer interface [polypeptide binding]; other site 418127003953 FBP binding site [chemical binding]; other site 418127003954 protein IIAGlc interface [polypeptide binding]; other site 418127003955 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 418127003956 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 418127003957 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 418127003958 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 418127003959 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 418127003960 bacterial Hfq-like; Region: Hfq; cd01716 418127003961 hexamer interface [polypeptide binding]; other site 418127003962 Sm1 motif; other site 418127003963 RNA binding site [nucleotide binding]; other site 418127003964 Sm2 motif; other site 418127003965 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 418127003966 catalytic residues [active] 418127003967 dimer interface [polypeptide binding]; other site 418127003968 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 418127003969 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 418127003970 HflX GTPase family; Region: HflX; cd01878 418127003971 G1 box; other site 418127003972 GTP/Mg2+ binding site [chemical binding]; other site 418127003973 Switch I region; other site 418127003974 G2 box; other site 418127003975 G3 box; other site 418127003976 Switch II region; other site 418127003977 G4 box; other site 418127003978 G5 box; other site 418127003979 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 418127003980 Aluminium resistance protein; Region: Alum_res; pfam06838 418127003981 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 418127003982 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 418127003983 DNA binding residues [nucleotide binding] 418127003984 putative dimer interface [polypeptide binding]; other site 418127003985 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 418127003986 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 418127003987 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 418127003988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 418127003989 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 418127003990 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 418127003991 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127003992 catalytic residue [active] 418127003993 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 418127003994 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 418127003995 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 418127003996 putative active site [active] 418127003997 catalytic site [active] 418127003998 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 418127003999 putative active site [active] 418127004000 catalytic site [active] 418127004001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 418127004002 Walker A/P-loop; other site 418127004003 ATP binding site [chemical binding]; other site 418127004004 ABC transporter; Region: ABC_tran; pfam00005 418127004005 Q-loop/lid; other site 418127004006 ABC transporter signature motif; other site 418127004007 Walker B; other site 418127004008 D-loop; other site 418127004009 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 418127004010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 418127004011 Histidine kinase; Region: HisKA_3; pfam07730 418127004012 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 418127004013 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 418127004014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127004015 active site 418127004016 phosphorylation site [posttranslational modification] 418127004017 intermolecular recognition site; other site 418127004018 dimerization interface [polypeptide binding]; other site 418127004019 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 418127004020 DNA binding residues [nucleotide binding] 418127004021 dimerization interface [polypeptide binding]; other site 418127004022 Staphylococcal nuclease homologues; Region: SNc; smart00318 418127004023 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 418127004024 Catalytic site; other site 418127004025 AAA domain; Region: AAA_11; pfam13086 418127004026 aspartate kinase; Reviewed; Region: PRK09034 418127004027 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 418127004028 putative catalytic residues [active] 418127004029 putative nucleotide binding site [chemical binding]; other site 418127004030 putative aspartate binding site [chemical binding]; other site 418127004031 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 418127004032 allosteric regulatory residue; other site 418127004033 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 418127004034 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 418127004035 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 418127004036 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 418127004037 threonine synthase; Reviewed; Region: PRK06721 418127004038 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 418127004039 homodimer interface [polypeptide binding]; other site 418127004040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127004041 catalytic residue [active] 418127004042 homoserine kinase; Provisional; Region: PRK01212 418127004043 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 418127004044 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 418127004045 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127004046 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 418127004047 active site 418127004048 motif I; other site 418127004049 motif II; other site 418127004050 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 418127004051 lysine transporter; Provisional; Region: PRK10836 418127004052 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 418127004053 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 418127004054 tetramer interface [polypeptide binding]; other site 418127004055 heme binding pocket [chemical binding]; other site 418127004056 NADPH binding site [chemical binding]; other site 418127004057 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 418127004058 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 418127004059 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 418127004060 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 418127004061 active site 418127004062 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 418127004063 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 418127004064 LexA repressor; Validated; Region: PRK00215 418127004065 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 418127004066 putative DNA binding site [nucleotide binding]; other site 418127004067 putative Zn2+ binding site [ion binding]; other site 418127004068 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 418127004069 Catalytic site [active] 418127004070 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 418127004071 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 418127004072 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 418127004073 TPP-binding site [chemical binding]; other site 418127004074 dimer interface [polypeptide binding]; other site 418127004075 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 418127004076 PYR/PP interface [polypeptide binding]; other site 418127004077 dimer interface [polypeptide binding]; other site 418127004078 TPP binding site [chemical binding]; other site 418127004079 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 418127004080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 418127004081 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 418127004082 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 418127004083 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 418127004084 active site 418127004085 metal binding site [ion binding]; metal-binding site 418127004086 DNA binding site [nucleotide binding] 418127004087 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 418127004088 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 418127004089 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 418127004090 Walker A/P-loop; other site 418127004091 ATP binding site [chemical binding]; other site 418127004092 Q-loop/lid; other site 418127004093 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 418127004094 ABC transporter signature motif; other site 418127004095 Walker B; other site 418127004096 D-loop; other site 418127004097 H-loop/switch region; other site 418127004098 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 418127004099 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 418127004100 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 418127004101 aconitate hydratase; Validated; Region: PRK09277 418127004102 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 418127004103 substrate binding site [chemical binding]; other site 418127004104 ligand binding site [chemical binding]; other site 418127004105 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 418127004106 substrate binding site [chemical binding]; other site 418127004107 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 418127004108 active site 418127004109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 418127004110 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 418127004111 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 418127004112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127004113 ATP binding site [chemical binding]; other site 418127004114 Mg2+ binding site [ion binding]; other site 418127004115 G-X-G motif; other site 418127004116 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 418127004117 anchoring element; other site 418127004118 dimer interface [polypeptide binding]; other site 418127004119 ATP binding site [chemical binding]; other site 418127004120 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 418127004121 active site 418127004122 putative metal-binding site [ion binding]; other site 418127004123 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 418127004124 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 418127004125 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 418127004126 CAP-like domain; other site 418127004127 active site 418127004128 primary dimer interface [polypeptide binding]; other site 418127004129 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 418127004130 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 418127004131 amino acid carrier protein; Region: agcS; TIGR00835 418127004132 CAT RNA binding domain; Region: CAT_RBD; smart01061 418127004133 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 418127004134 PRD domain; Region: PRD; pfam00874 418127004135 PRD domain; Region: PRD; pfam00874 418127004136 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 418127004137 Domain of unknown function DUF20; Region: UPF0118; pfam01594 418127004138 Predicted integral membrane protein [Function unknown]; Region: COG0392 418127004139 Uncharacterized conserved protein [Function unknown]; Region: COG2898 418127004140 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 418127004141 methionine sulfoxide reductase A; Provisional; Region: PRK14054 418127004142 Transcriptional regulator [Transcription]; Region: LytR; COG1316 418127004143 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 418127004144 active site 1 [active] 418127004145 dimer interface [polypeptide binding]; other site 418127004146 hexamer interface [polypeptide binding]; other site 418127004147 active site 2 [active] 418127004148 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 418127004149 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 418127004150 active site 418127004151 DNA binding site [nucleotide binding] 418127004152 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 418127004153 prephenate dehydrogenase; Validated; Region: PRK06545 418127004154 prephenate dehydrogenase; Validated; Region: PRK08507 418127004155 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 418127004156 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 418127004157 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 418127004158 putative oligomer interface [polypeptide binding]; other site 418127004159 putative active site [active] 418127004160 metal binding site [ion binding]; metal-binding site 418127004161 anthranilate synthase component I; Provisional; Region: PRK13567 418127004162 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 418127004163 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 418127004164 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 418127004165 Glutamine amidotransferase class-I; Region: GATase; pfam00117 418127004166 glutamine binding [chemical binding]; other site 418127004167 catalytic triad [active] 418127004168 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 418127004169 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 418127004170 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 418127004171 active site 418127004172 ribulose/triose binding site [chemical binding]; other site 418127004173 phosphate binding site [ion binding]; other site 418127004174 substrate (anthranilate) binding pocket [chemical binding]; other site 418127004175 product (indole) binding pocket [chemical binding]; other site 418127004176 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 418127004177 active site 418127004178 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 418127004179 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 418127004180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127004181 catalytic residue [active] 418127004182 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 418127004183 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 418127004184 substrate binding site [chemical binding]; other site 418127004185 active site 418127004186 catalytic residues [active] 418127004187 heterodimer interface [polypeptide binding]; other site 418127004188 FemAB family; Region: FemAB; pfam02388 418127004189 FlxA-like protein; Region: FlxA; pfam14282 418127004190 FemAB family; Region: FemAB; pfam02388 418127004191 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 418127004192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127004193 active site 418127004194 motif I; other site 418127004195 motif II; other site 418127004196 SWIM zinc finger; Region: SWIM; pfam04434 418127004197 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 418127004198 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 418127004199 Walker A/P-loop; other site 418127004200 ATP binding site [chemical binding]; other site 418127004201 Q-loop/lid; other site 418127004202 ABC transporter signature motif; other site 418127004203 Walker B; other site 418127004204 D-loop; other site 418127004205 H-loop/switch region; other site 418127004206 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 418127004207 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 418127004208 Walker A/P-loop; other site 418127004209 ATP binding site [chemical binding]; other site 418127004210 Q-loop/lid; other site 418127004211 ABC transporter signature motif; other site 418127004212 Walker B; other site 418127004213 D-loop; other site 418127004214 H-loop/switch region; other site 418127004215 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 418127004216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127004217 dimer interface [polypeptide binding]; other site 418127004218 conserved gate region; other site 418127004219 putative PBP binding loops; other site 418127004220 ABC-ATPase subunit interface; other site 418127004221 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 418127004222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127004223 dimer interface [polypeptide binding]; other site 418127004224 conserved gate region; other site 418127004225 putative PBP binding loops; other site 418127004226 ABC-ATPase subunit interface; other site 418127004227 Inorganic H+ pyrophosphatase; Region: H_PPase; cl11452 418127004228 oligoendopeptidase F; Region: pepF; TIGR00181 418127004229 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 418127004230 active site 418127004231 Zn binding site [ion binding]; other site 418127004232 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 418127004233 PhoU domain; Region: PhoU; pfam01895 418127004234 PhoU domain; Region: PhoU; pfam01895 418127004235 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 418127004236 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 418127004237 Walker A/P-loop; other site 418127004238 ATP binding site [chemical binding]; other site 418127004239 Q-loop/lid; other site 418127004240 ABC transporter signature motif; other site 418127004241 Walker B; other site 418127004242 D-loop; other site 418127004243 H-loop/switch region; other site 418127004244 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 418127004245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127004246 dimer interface [polypeptide binding]; other site 418127004247 conserved gate region; other site 418127004248 putative PBP binding loops; other site 418127004249 ABC-ATPase subunit interface; other site 418127004250 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 418127004251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127004252 dimer interface [polypeptide binding]; other site 418127004253 conserved gate region; other site 418127004254 ABC-ATPase subunit interface; other site 418127004255 phosphate binding protein; Region: ptsS_2; TIGR02136 418127004256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 418127004257 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 418127004258 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 418127004259 S1 domain; Region: S1_2; pfam13509 418127004260 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 418127004261 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 418127004262 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 418127004263 ABC transporter; Region: ABC_tran_2; pfam12848 418127004264 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 418127004265 aspartate kinase; Reviewed; Region: PRK06635 418127004266 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 418127004267 putative nucleotide binding site [chemical binding]; other site 418127004268 putative catalytic residues [active] 418127004269 putative Mg ion binding site [ion binding]; other site 418127004270 putative aspartate binding site [chemical binding]; other site 418127004271 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 418127004272 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 418127004273 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 418127004274 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 418127004275 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 418127004276 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 418127004277 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 418127004278 dimer interface [polypeptide binding]; other site 418127004279 active site 418127004280 catalytic residue [active] 418127004281 dihydrodipicolinate reductase; Provisional; Region: PRK00048 418127004282 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 418127004283 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 418127004284 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 418127004285 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 418127004286 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 418127004287 active site 418127004288 trimer interface [polypeptide binding]; other site 418127004289 substrate binding site [chemical binding]; other site 418127004290 CoA binding site [chemical binding]; other site 418127004291 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 418127004292 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 418127004293 metal binding site [ion binding]; metal-binding site 418127004294 dimer interface [polypeptide binding]; other site 418127004295 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 418127004296 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 418127004297 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 418127004298 catalytic residue [active] 418127004299 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 418127004300 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 418127004301 active site 418127004302 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 418127004303 substrate binding site [chemical binding]; other site 418127004304 catalytic residues [active] 418127004305 dimer interface [polypeptide binding]; other site 418127004306 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 418127004307 DNA-binding site [nucleotide binding]; DNA binding site 418127004308 RNA-binding motif; other site 418127004309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 418127004310 acylphosphatase; Provisional; Region: PRK14431 418127004311 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 418127004312 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 418127004313 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 418127004314 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 418127004315 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 418127004316 metal ion-dependent adhesion site (MIDAS); other site 418127004317 MoxR-like ATPases [General function prediction only]; Region: COG0714 418127004318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127004319 Walker A motif; other site 418127004320 ATP binding site [chemical binding]; other site 418127004321 Walker B motif; other site 418127004322 arginine finger; other site 418127004323 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 418127004324 active site 418127004325 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 418127004326 active site 418127004327 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 418127004328 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 418127004329 E3 interaction surface; other site 418127004330 lipoyl attachment site [posttranslational modification]; other site 418127004331 e3 binding domain; Region: E3_binding; pfam02817 418127004332 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 418127004333 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 418127004334 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 418127004335 TPP-binding site [chemical binding]; other site 418127004336 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 418127004337 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 418127004338 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 418127004339 HAMP domain; Region: HAMP; pfam00672 418127004340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 418127004341 dimer interface [polypeptide binding]; other site 418127004342 phosphorylation site [posttranslational modification] 418127004343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127004344 ATP binding site [chemical binding]; other site 418127004345 Mg2+ binding site [ion binding]; other site 418127004346 G-X-G motif; other site 418127004347 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127004348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127004349 active site 418127004350 phosphorylation site [posttranslational modification] 418127004351 intermolecular recognition site; other site 418127004352 dimerization interface [polypeptide binding]; other site 418127004353 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 418127004354 DNA binding site [nucleotide binding] 418127004355 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 418127004356 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 418127004357 active site 418127004358 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 418127004359 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 418127004360 active site 418127004361 homodimer interface [polypeptide binding]; other site 418127004362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127004363 Coenzyme A binding pocket [chemical binding]; other site 418127004364 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 418127004365 C-terminal peptidase (prc); Region: prc; TIGR00225 418127004366 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 418127004367 protein binding site [polypeptide binding]; other site 418127004368 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 418127004369 Catalytic dyad [active] 418127004370 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 418127004371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 418127004372 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 418127004373 HPr interaction site; other site 418127004374 glycerol kinase (GK) interaction site [polypeptide binding]; other site 418127004375 active site 418127004376 phosphorylation site [posttranslational modification] 418127004377 methionine sulfoxide reductase B; Provisional; Region: PRK00222 418127004378 SelR domain; Region: SelR; pfam01641 418127004379 methionine sulfoxide reductase A; Provisional; Region: PRK13014 418127004380 EDD domain protein, DegV family; Region: DegV; TIGR00762 418127004381 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 418127004382 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 418127004383 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 418127004384 folate binding site [chemical binding]; other site 418127004385 NADP+ binding site [chemical binding]; other site 418127004386 thymidylate synthase; Region: thym_sym; TIGR03284 418127004387 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 418127004388 dimerization interface [polypeptide binding]; other site 418127004389 active site 418127004390 Disulphide isomerase; Region: Disulph_isomer; pfam06491 418127004391 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 418127004392 Virulence factor; Region: Virulence_fact; pfam13769 418127004393 HEAT repeats; Region: HEAT_2; pfam13646 418127004394 HEAT repeat; Region: HEAT; pfam02985 418127004395 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 418127004396 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 418127004397 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 418127004398 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 418127004399 RNA/DNA hybrid binding site [nucleotide binding]; other site 418127004400 active site 418127004401 GA module; Region: GA; smart00844 418127004402 GA module; Region: GA; smart00844 418127004403 GA module; Region: GA; smart00844 418127004404 GA module; Region: GA; smart00844 418127004405 GA module; Region: GA; smart00844 418127004406 GA module; Region: GA; smart00844 418127004407 GA module; Region: GA; smart00844 418127004408 GA module; Region: GA; smart00844 418127004409 GA module; Region: GA; smart00844 418127004410 GA module; Region: GA; smart00844 418127004411 GA module; Region: GA; smart00844 418127004412 GA module; Region: GA; smart00844 418127004413 GA module; Region: GA; smart00844 418127004414 GA module; Region: GA; smart00844 418127004415 GA module; Region: GA; smart00844 418127004416 GA module; Region: GA; smart00844 418127004417 GA module; Region: GA; smart00844 418127004418 GA module; Region: GA; smart00844 418127004419 GA module; Region: GA; pfam01468 418127004420 GA module; Region: GA; smart00844 418127004421 GA module; Region: GA; smart00844 418127004422 GA module; Region: GA; smart00844 418127004423 GA module; Region: GA; smart00844 418127004424 GA module; Region: GA; pfam01468 418127004425 GA module; Region: GA; smart00844 418127004426 GA module; Region: GA; smart00844 418127004427 GA module; Region: GA; smart00844 418127004428 GA module; Region: GA; smart00844 418127004429 GA module; Region: GA; smart00844 418127004430 GA module; Region: GA; smart00844 418127004431 GA module; Region: GA; smart00844 418127004432 GA module; Region: GA; smart00844 418127004433 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 418127004434 GA module; Region: GA; pfam01468 418127004435 GA module; Region: GA; smart00844 418127004436 GA module; Region: GA; smart00844 418127004437 GA module; Region: GA; smart00844 418127004438 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 418127004439 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 418127004440 GA module; Region: GA; smart00844 418127004441 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 418127004442 GA module; Region: GA; smart00844 418127004443 GA module; Region: GA; smart00844 418127004444 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 418127004445 GA module; Region: GA; smart00844 418127004446 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 418127004447 GA module; Region: GA; smart00844 418127004448 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 418127004449 GA module; Region: GA; smart00844 418127004450 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 418127004451 GA module; Region: GA; smart00844 418127004452 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 418127004453 Amino acid permease; Region: AA_permease_2; pfam13520 418127004454 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 418127004455 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 418127004456 tetramer interface [polypeptide binding]; other site 418127004457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127004458 catalytic residue [active] 418127004459 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 418127004460 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 418127004461 hexamer interface [polypeptide binding]; other site 418127004462 ligand binding site [chemical binding]; other site 418127004463 putative active site [active] 418127004464 NAD(P) binding site [chemical binding]; other site 418127004465 5'-3' exonuclease; Region: 53EXOc; smart00475 418127004466 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 418127004467 active site 418127004468 metal binding site 1 [ion binding]; metal-binding site 418127004469 putative 5' ssDNA interaction site; other site 418127004470 metal binding site 3; metal-binding site 418127004471 metal binding site 2 [ion binding]; metal-binding site 418127004472 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 418127004473 putative DNA binding site [nucleotide binding]; other site 418127004474 putative metal binding site [ion binding]; other site 418127004475 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 418127004476 Dynamin family; Region: Dynamin_N; pfam00350 418127004477 G1 box; other site 418127004478 GTP/Mg2+ binding site [chemical binding]; other site 418127004479 G2 box; other site 418127004480 Switch I region; other site 418127004481 G3 box; other site 418127004482 Switch II region; other site 418127004483 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 418127004484 G4 box; other site 418127004485 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 418127004486 Dynamin family; Region: Dynamin_N; pfam00350 418127004487 G1 box; other site 418127004488 GTP/Mg2+ binding site [chemical binding]; other site 418127004489 G2 box; other site 418127004490 Switch I region; other site 418127004491 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 418127004492 G3 box; other site 418127004493 Switch II region; other site 418127004494 GTP/Mg2+ binding site [chemical binding]; other site 418127004495 G4 box; other site 418127004496 G5 box; other site 418127004497 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 418127004498 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 418127004499 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 418127004500 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 418127004501 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 418127004502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 418127004503 cell division protein GpsB; Provisional; Region: PRK14127 418127004504 DivIVA domain; Region: DivI1A_domain; TIGR03544 418127004505 hypothetical protein; Provisional; Region: PRK13660 418127004506 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 418127004507 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 418127004508 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 418127004509 Transglycosylase; Region: Transgly; pfam00912 418127004510 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 418127004511 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 418127004512 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 418127004513 minor groove reading motif; other site 418127004514 helix-hairpin-helix signature motif; other site 418127004515 substrate binding pocket [chemical binding]; other site 418127004516 active site 418127004517 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 418127004518 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 418127004519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 418127004520 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 418127004521 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 418127004522 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 418127004523 putative dimer interface [polypeptide binding]; other site 418127004524 putative anticodon binding site; other site 418127004525 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 418127004526 homodimer interface [polypeptide binding]; other site 418127004527 motif 1; other site 418127004528 motif 2; other site 418127004529 active site 418127004530 motif 3; other site 418127004531 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 418127004532 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 418127004533 active site 418127004534 catalytic site [active] 418127004535 substrate binding site [chemical binding]; other site 418127004536 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 418127004537 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 418127004538 Biotin operon repressor [Transcription]; Region: BirA; COG1654 418127004539 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 418127004540 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 418127004541 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 418127004542 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 418127004543 active site 418127004544 NTP binding site [chemical binding]; other site 418127004545 metal binding triad [ion binding]; metal-binding site 418127004546 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 418127004547 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 418127004548 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 418127004549 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 418127004550 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 418127004551 homodimer interface [polypeptide binding]; other site 418127004552 metal binding site [ion binding]; metal-binding site 418127004553 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 418127004554 Predicted membrane protein [Function unknown]; Region: COG4347 418127004555 Uncharacterized conserved protein [Function unknown]; Region: COG5582 418127004556 UPF0302 domain; Region: UPF0302; pfam08864 418127004557 A short protein domain of unknown function; Region: IDEAL; smart00914 418127004558 TPR repeat; Region: TPR_11; pfam13414 418127004559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 418127004560 binding surface 418127004561 TPR motif; other site 418127004562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 418127004563 TPR motif; other site 418127004564 binding surface 418127004565 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 418127004566 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 418127004567 hinge; other site 418127004568 active site 418127004569 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 418127004570 active site 418127004571 NAD binding site [chemical binding]; other site 418127004572 metal binding site [ion binding]; metal-binding site 418127004573 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 418127004574 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 418127004575 Tetramer interface [polypeptide binding]; other site 418127004576 active site 418127004577 FMN-binding site [chemical binding]; other site 418127004578 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 418127004579 active site 418127004580 multimer interface [polypeptide binding]; other site 418127004581 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 418127004582 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 418127004583 substrate binding pocket [chemical binding]; other site 418127004584 chain length determination region; other site 418127004585 substrate-Mg2+ binding site; other site 418127004586 catalytic residues [active] 418127004587 aspartate-rich region 1; other site 418127004588 active site lid residues [active] 418127004589 aspartate-rich region 2; other site 418127004590 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 418127004591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127004592 S-adenosylmethionine binding site [chemical binding]; other site 418127004593 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 418127004594 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 418127004595 IHF dimer interface [polypeptide binding]; other site 418127004596 IHF - DNA interface [nucleotide binding]; other site 418127004597 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 418127004598 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 418127004599 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 418127004600 GTP-binding protein Der; Reviewed; Region: PRK00093 418127004601 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 418127004602 G1 box; other site 418127004603 GTP/Mg2+ binding site [chemical binding]; other site 418127004604 Switch I region; other site 418127004605 G2 box; other site 418127004606 Switch II region; other site 418127004607 G3 box; other site 418127004608 G4 box; other site 418127004609 G5 box; other site 418127004610 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 418127004611 G1 box; other site 418127004612 GTP/Mg2+ binding site [chemical binding]; other site 418127004613 Switch I region; other site 418127004614 G2 box; other site 418127004615 G3 box; other site 418127004616 Switch II region; other site 418127004617 G4 box; other site 418127004618 G5 box; other site 418127004619 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 418127004620 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 418127004621 RNA binding site [nucleotide binding]; other site 418127004622 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 418127004623 RNA binding site [nucleotide binding]; other site 418127004624 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 418127004625 RNA binding site [nucleotide binding]; other site 418127004626 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 418127004627 RNA binding site [nucleotide binding]; other site 418127004628 similar to hypothetical protein 418127004629 cytidylate kinase; Provisional; Region: cmk; PRK00023 418127004630 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 418127004631 CMP-binding site; other site 418127004632 The sites determining sugar specificity; other site 418127004633 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 418127004634 active site 418127004635 homotetramer interface [polypeptide binding]; other site 418127004636 homodimer interface [polypeptide binding]; other site 418127004637 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 418127004638 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 418127004639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 418127004640 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 418127004641 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 418127004642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127004643 ATP binding site [chemical binding]; other site 418127004644 putative Mg++ binding site [ion binding]; other site 418127004645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127004646 nucleotide binding region [chemical binding]; other site 418127004647 ATP-binding site [chemical binding]; other site 418127004648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 418127004649 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 418127004650 Predicted membrane protein [Function unknown]; Region: COG3601 418127004651 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 418127004652 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 418127004653 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 418127004654 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 418127004655 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 418127004656 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 418127004657 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 418127004658 dimerization interface [polypeptide binding]; other site 418127004659 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 418127004660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 418127004661 dimer interface [polypeptide binding]; other site 418127004662 phosphorylation site [posttranslational modification] 418127004663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127004664 ATP binding site [chemical binding]; other site 418127004665 Mg2+ binding site [ion binding]; other site 418127004666 G-X-G motif; other site 418127004667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127004668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127004669 active site 418127004670 phosphorylation site [posttranslational modification] 418127004671 intermolecular recognition site; other site 418127004672 dimerization interface [polypeptide binding]; other site 418127004673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 418127004674 DNA binding site [nucleotide binding] 418127004675 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 418127004676 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 418127004677 RNA binding surface [nucleotide binding]; other site 418127004678 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 418127004679 active site 418127004680 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 418127004681 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 418127004682 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 418127004683 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 418127004684 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 418127004685 active site 418127004686 Int/Topo IB signature motif; other site 418127004687 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 418127004688 metal binding site 2 [ion binding]; metal-binding site 418127004689 putative DNA binding helix; other site 418127004690 metal binding site 1 [ion binding]; metal-binding site 418127004691 dimer interface [polypeptide binding]; other site 418127004692 structural Zn2+ binding site [ion binding]; other site 418127004693 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 418127004694 dimer interface [polypeptide binding]; other site 418127004695 ADP-ribose binding site [chemical binding]; other site 418127004696 active site 418127004697 nudix motif; other site 418127004698 metal binding site [ion binding]; metal-binding site 418127004699 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 418127004700 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 418127004701 active site 418127004702 catalytic tetrad [active] 418127004703 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 418127004704 classical (c) SDRs; Region: SDR_c; cd05233 418127004705 NAD(P) binding site [chemical binding]; other site 418127004706 active site 418127004707 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 418127004708 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 418127004709 ribonuclease Z; Region: RNase_Z; TIGR02651 418127004710 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 418127004711 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 418127004712 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 418127004713 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 418127004714 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 418127004715 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 418127004716 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 418127004717 Ca binding site [ion binding]; other site 418127004718 active site 418127004719 catalytic site [active] 418127004720 Transcriptional regulators [Transcription]; Region: PurR; COG1609 418127004721 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 418127004722 DNA binding site [nucleotide binding] 418127004723 domain linker motif; other site 418127004724 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 418127004725 putative ligand binding site [chemical binding]; other site 418127004726 putative dimerization interface [polypeptide binding]; other site 418127004727 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 418127004728 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 418127004729 H+ Antiporter protein; Region: 2A0121; TIGR00900 418127004730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127004731 putative substrate translocation pore; other site 418127004732 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 418127004733 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 418127004734 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 418127004735 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 418127004736 peptidase T-like protein; Region: PepT-like; TIGR01883 418127004737 metal binding site [ion binding]; metal-binding site 418127004738 putative dimer interface [polypeptide binding]; other site 418127004739 Predicted membrane protein [Function unknown]; Region: COG4129 418127004740 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 418127004741 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 418127004742 Disulphide isomerase; Region: Disulph_isomer; pfam06491 418127004743 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 418127004744 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 418127004745 E3 interaction surface; other site 418127004746 lipoyl attachment site [posttranslational modification]; other site 418127004747 e3 binding domain; Region: E3_binding; pfam02817 418127004748 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 418127004749 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 418127004750 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 418127004751 alpha subunit interface [polypeptide binding]; other site 418127004752 TPP binding site [chemical binding]; other site 418127004753 heterodimer interface [polypeptide binding]; other site 418127004754 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 418127004755 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 418127004756 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 418127004757 tetramer interface [polypeptide binding]; other site 418127004758 TPP-binding site [chemical binding]; other site 418127004759 heterodimer interface [polypeptide binding]; other site 418127004760 phosphorylation loop region [posttranslational modification] 418127004761 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 418127004762 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 418127004763 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 418127004764 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 418127004765 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 418127004766 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 418127004767 Walker A/P-loop; other site 418127004768 ATP binding site [chemical binding]; other site 418127004769 Q-loop/lid; other site 418127004770 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 418127004771 ABC transporter signature motif; other site 418127004772 Walker B; other site 418127004773 D-loop; other site 418127004774 H-loop/switch region; other site 418127004775 arginine repressor; Provisional; Region: PRK04280 418127004776 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 418127004777 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 418127004778 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 418127004779 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 418127004780 substrate binding pocket [chemical binding]; other site 418127004781 chain length determination region; other site 418127004782 substrate-Mg2+ binding site; other site 418127004783 catalytic residues [active] 418127004784 aspartate-rich region 1; other site 418127004785 active site lid residues [active] 418127004786 aspartate-rich region 2; other site 418127004787 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 418127004788 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 418127004789 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 418127004790 generic binding surface II; other site 418127004791 generic binding surface I; other site 418127004792 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 418127004793 putative RNA binding site [nucleotide binding]; other site 418127004794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 418127004795 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 418127004796 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 418127004797 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 418127004798 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 418127004799 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 418127004800 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 418127004801 carboxyltransferase (CT) interaction site; other site 418127004802 biotinylation site [posttranslational modification]; other site 418127004803 elongation factor P; Validated; Region: PRK00529 418127004804 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 418127004805 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 418127004806 RNA binding site [nucleotide binding]; other site 418127004807 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 418127004808 RNA binding site [nucleotide binding]; other site 418127004809 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 418127004810 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 418127004811 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 418127004812 active site 418127004813 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 418127004814 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 418127004815 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 418127004816 active site residue [active] 418127004817 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 418127004818 tetramer interface [polypeptide binding]; other site 418127004819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127004820 catalytic residue [active] 418127004821 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 418127004822 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 418127004823 tetramer interface [polypeptide binding]; other site 418127004824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127004825 catalytic residue [active] 418127004826 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 418127004827 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 418127004828 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 418127004829 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 418127004830 ADP binding site [chemical binding]; other site 418127004831 magnesium binding site [ion binding]; other site 418127004832 putative shikimate binding site; other site 418127004833 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 418127004834 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 418127004835 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 418127004836 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 418127004837 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 418127004838 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 418127004839 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 418127004840 Type II/IV secretion system protein; Region: T2SE; pfam00437 418127004841 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 418127004842 Walker A motif; other site 418127004843 ATP binding site [chemical binding]; other site 418127004844 Walker B motif; other site 418127004845 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 418127004846 Uncharacterized conserved protein [Function unknown]; Region: COG0011 418127004847 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 418127004848 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 418127004849 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 418127004850 Rhomboid family; Region: Rhomboid; pfam01694 418127004851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 418127004852 binding surface 418127004853 TPR motif; other site 418127004854 Tetratricopeptide repeat; Region: TPR_16; pfam13432 418127004855 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 418127004856 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 418127004857 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 418127004858 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 418127004859 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 418127004860 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 418127004861 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 418127004862 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 418127004863 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 418127004864 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 418127004865 metal binding site 2 [ion binding]; metal-binding site 418127004866 putative DNA binding helix; other site 418127004867 metal binding site 1 [ion binding]; metal-binding site 418127004868 dimer interface [polypeptide binding]; other site 418127004869 structural Zn2+ binding site [ion binding]; other site 418127004870 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 418127004871 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 418127004872 ABC-ATPase subunit interface; other site 418127004873 dimer interface [polypeptide binding]; other site 418127004874 putative PBP binding regions; other site 418127004875 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 418127004876 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 418127004877 endonuclease IV; Provisional; Region: PRK01060 418127004878 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 418127004879 AP (apurinic/apyrimidinic) site pocket; other site 418127004880 DNA interaction; other site 418127004881 Metal-binding active site; metal-binding site 418127004882 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 418127004883 DEAD-like helicases superfamily; Region: DEXDc; smart00487 418127004884 ATP binding site [chemical binding]; other site 418127004885 putative Mg++ binding site [ion binding]; other site 418127004886 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127004887 nucleotide binding region [chemical binding]; other site 418127004888 ATP-binding site [chemical binding]; other site 418127004889 Uncharacterized conserved protein [Function unknown]; Region: COG0327 418127004890 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 418127004891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 418127004892 Uncharacterized conserved protein [Function unknown]; Region: COG0327 418127004893 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 418127004894 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 418127004895 Family of unknown function (DUF633); Region: DUF633; pfam04816 418127004896 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 418127004897 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 418127004898 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 418127004899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 418127004900 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 418127004901 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 418127004902 DNA binding residues [nucleotide binding] 418127004903 DNA primase, catalytic core; Region: dnaG; TIGR01391 418127004904 CHC2 zinc finger; Region: zf-CHC2; pfam01807 418127004905 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 418127004906 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 418127004907 active site 418127004908 metal binding site [ion binding]; metal-binding site 418127004909 interdomain interaction site; other site 418127004910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 418127004911 HTH domain; Region: HTH_11; pfam08279 418127004912 FOG: CBS domain [General function prediction only]; Region: COG0517 418127004913 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 418127004914 glycyl-tRNA synthetase; Provisional; Region: PRK04173 418127004915 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 418127004916 motif 1; other site 418127004917 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 418127004918 active site 418127004919 motif 2; other site 418127004920 motif 3; other site 418127004921 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 418127004922 anticodon binding site; other site 418127004923 DNA repair protein RecO; Region: reco; TIGR00613 418127004924 Recombination protein O N terminal; Region: RecO_N; pfam11967 418127004925 Recombination protein O C terminal; Region: RecO_C; pfam02565 418127004926 GTPase Era; Reviewed; Region: era; PRK00089 418127004927 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 418127004928 G1 box; other site 418127004929 GTP/Mg2+ binding site [chemical binding]; other site 418127004930 Switch I region; other site 418127004931 G2 box; other site 418127004932 Switch II region; other site 418127004933 G3 box; other site 418127004934 G4 box; other site 418127004935 G5 box; other site 418127004936 KH domain; Region: KH_2; pfam07650 418127004937 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 418127004938 active site 418127004939 catalytic motif [active] 418127004940 Zn binding site [ion binding]; other site 418127004941 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 418127004942 metal-binding heat shock protein; Provisional; Region: PRK00016 418127004943 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 418127004944 PhoH-like protein; Region: PhoH; pfam02562 418127004945 hypothetical protein; Provisional; Region: PRK13665 418127004946 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 418127004947 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 418127004948 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 418127004949 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 418127004950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 418127004951 FeS/SAM binding site; other site 418127004952 TRAM domain; Region: TRAM; cl01282 418127004953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 418127004954 RNA methyltransferase, RsmE family; Region: TIGR00046 418127004955 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 418127004956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127004957 S-adenosylmethionine binding site [chemical binding]; other site 418127004958 chaperone protein DnaJ; Provisional; Region: PRK14280 418127004959 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 418127004960 HSP70 interaction site [polypeptide binding]; other site 418127004961 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 418127004962 substrate binding site [polypeptide binding]; other site 418127004963 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 418127004964 Zn binding sites [ion binding]; other site 418127004965 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 418127004966 dimer interface [polypeptide binding]; other site 418127004967 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 418127004968 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 418127004969 nucleotide binding site [chemical binding]; other site 418127004970 NEF interaction site [polypeptide binding]; other site 418127004971 SBD interface [polypeptide binding]; other site 418127004972 heat shock protein GrpE; Provisional; Region: PRK14140 418127004973 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 418127004974 dimer interface [polypeptide binding]; other site 418127004975 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 418127004976 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 418127004977 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 418127004978 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 418127004979 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 418127004980 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 418127004981 FeS/SAM binding site; other site 418127004982 HemN C-terminal domain; Region: HemN_C; pfam06969 418127004983 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 418127004984 GTP-binding protein LepA; Provisional; Region: PRK05433 418127004985 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 418127004986 G1 box; other site 418127004987 putative GEF interaction site [polypeptide binding]; other site 418127004988 GTP/Mg2+ binding site [chemical binding]; other site 418127004989 Switch I region; other site 418127004990 G2 box; other site 418127004991 G3 box; other site 418127004992 Switch II region; other site 418127004993 G4 box; other site 418127004994 G5 box; other site 418127004995 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 418127004996 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 418127004997 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 418127004998 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 418127004999 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 418127005000 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 418127005001 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 418127005002 Competence protein; Region: Competence; pfam03772 418127005003 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 418127005004 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 418127005005 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 418127005006 catalytic motif [active] 418127005007 Zn binding site [ion binding]; other site 418127005008 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 418127005009 Helix-hairpin-helix motif; Region: HHH; pfam00633 418127005010 Methyltransferase domain; Region: Methyltransf_31; pfam13847 418127005011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127005012 S-adenosylmethionine binding site [chemical binding]; other site 418127005013 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 418127005014 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 418127005015 Zn2+ binding site [ion binding]; other site 418127005016 Mg2+ binding site [ion binding]; other site 418127005017 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 418127005018 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 418127005019 active site 418127005020 (T/H)XGH motif; other site 418127005021 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 418127005022 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 418127005023 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 418127005024 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 418127005025 shikimate binding site; other site 418127005026 NAD(P) binding site [chemical binding]; other site 418127005027 GTPase YqeH; Provisional; Region: PRK13796 418127005028 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 418127005029 GTP/Mg2+ binding site [chemical binding]; other site 418127005030 G4 box; other site 418127005031 G5 box; other site 418127005032 G1 box; other site 418127005033 Switch I region; other site 418127005034 G2 box; other site 418127005035 G3 box; other site 418127005036 Switch II region; other site 418127005037 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 418127005038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127005039 active site 418127005040 motif I; other site 418127005041 motif II; other site 418127005042 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 418127005043 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 418127005044 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005045 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005046 Fic family protein [Function unknown]; Region: COG3177 418127005047 Fic/DOC family; Region: Fic; pfam02661 418127005048 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 418127005049 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 418127005050 putative active site [active] 418127005051 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 418127005052 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 418127005053 ATP-grasp domain; Region: ATP-grasp_4; cl17255 418127005054 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 418127005055 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 418127005056 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 418127005057 carboxyltransferase (CT) interaction site; other site 418127005058 biotinylation site [posttranslational modification]; other site 418127005059 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 418127005060 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 418127005061 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 418127005062 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 418127005063 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 418127005064 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 418127005065 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 418127005066 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 418127005067 Sugar specificity; other site 418127005068 Pyrimidine base specificity; other site 418127005069 ATP-binding site [chemical binding]; other site 418127005070 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 418127005071 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 418127005072 Peptidase family U32; Region: Peptidase_U32; pfam01136 418127005073 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 418127005074 Peptidase family U32; Region: Peptidase_U32; pfam01136 418127005075 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 418127005076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127005077 S-adenosylmethionine binding site [chemical binding]; other site 418127005078 hypothetical protein; Provisional; Region: PRK13678 418127005079 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 418127005080 hypothetical protein; Provisional; Region: PRK05473 418127005081 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 418127005082 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 418127005083 motif 1; other site 418127005084 active site 418127005085 motif 2; other site 418127005086 motif 3; other site 418127005087 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 418127005088 DHHA1 domain; Region: DHHA1; pfam02272 418127005089 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 418127005090 AAA domain; Region: AAA_30; pfam13604 418127005091 Family description; Region: UvrD_C_2; pfam13538 418127005092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 418127005093 binding surface 418127005094 TPR motif; other site 418127005095 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 418127005096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 418127005097 binding surface 418127005098 TPR motif; other site 418127005099 TPR repeat; Region: TPR_11; pfam13414 418127005100 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 418127005101 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 418127005102 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 418127005103 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 418127005104 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127005105 catalytic residue [active] 418127005106 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 418127005107 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 418127005108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 418127005109 Predicted transcriptional regulator [Transcription]; Region: COG1959 418127005110 Transcriptional regulator; Region: Rrf2; pfam02082 418127005111 recombination factor protein RarA; Reviewed; Region: PRK13342 418127005112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127005113 Walker A motif; other site 418127005114 ATP binding site [chemical binding]; other site 418127005115 Walker B motif; other site 418127005116 arginine finger; other site 418127005117 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 418127005118 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 418127005119 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 418127005120 putative ATP binding site [chemical binding]; other site 418127005121 putative substrate interface [chemical binding]; other site 418127005122 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 418127005123 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 418127005124 dimer interface [polypeptide binding]; other site 418127005125 anticodon binding site; other site 418127005126 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 418127005127 homodimer interface [polypeptide binding]; other site 418127005128 motif 1; other site 418127005129 active site 418127005130 motif 2; other site 418127005131 GAD domain; Region: GAD; pfam02938 418127005132 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 418127005133 motif 3; other site 418127005134 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 418127005135 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 418127005136 dimer interface [polypeptide binding]; other site 418127005137 motif 1; other site 418127005138 active site 418127005139 motif 2; other site 418127005140 motif 3; other site 418127005141 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 418127005142 anticodon binding site; other site 418127005143 Bacterial SH3 domain homologues; Region: SH3b; smart00287 418127005144 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 418127005145 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 418127005146 active site 418127005147 metal binding site [ion binding]; metal-binding site 418127005148 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 418127005149 putative active site [active] 418127005150 dimerization interface [polypeptide binding]; other site 418127005151 putative tRNAtyr binding site [nucleotide binding]; other site 418127005152 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 418127005153 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 418127005154 Zn2+ binding site [ion binding]; other site 418127005155 Mg2+ binding site [ion binding]; other site 418127005156 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 418127005157 synthetase active site [active] 418127005158 NTP binding site [chemical binding]; other site 418127005159 metal binding site [ion binding]; metal-binding site 418127005160 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 418127005161 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 418127005162 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 418127005163 active site 418127005164 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 418127005165 DHH family; Region: DHH; pfam01368 418127005166 DHHA1 domain; Region: DHHA1; pfam02272 418127005167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 418127005168 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 418127005169 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 418127005170 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 418127005171 Protein export membrane protein; Region: SecD_SecF; pfam02355 418127005172 Preprotein translocase subunit; Region: YajC; pfam02699 418127005173 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 418127005174 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 418127005175 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 418127005176 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 418127005177 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 418127005178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127005179 Walker A motif; other site 418127005180 ATP binding site [chemical binding]; other site 418127005181 Walker B motif; other site 418127005182 arginine finger; other site 418127005183 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 418127005184 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 418127005185 RuvA N terminal domain; Region: RuvA_N; pfam01330 418127005186 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 418127005187 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 418127005188 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 418127005189 GTPase CgtA; Reviewed; Region: obgE; PRK12297 418127005190 GTP1/OBG; Region: GTP1_OBG; pfam01018 418127005191 Obg GTPase; Region: Obg; cd01898 418127005192 G1 box; other site 418127005193 GTP/Mg2+ binding site [chemical binding]; other site 418127005194 Switch I region; other site 418127005195 G2 box; other site 418127005196 G3 box; other site 418127005197 Switch II region; other site 418127005198 G4 box; other site 418127005199 G5 box; other site 418127005200 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 418127005201 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 418127005202 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 418127005203 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 418127005204 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 418127005205 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 418127005206 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 418127005207 rod shape-determining protein MreC; Region: MreC; pfam04085 418127005208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127005209 S-adenosylmethionine binding site [chemical binding]; other site 418127005210 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 418127005211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127005212 S-adenosylmethionine binding site [chemical binding]; other site 418127005213 aminoglycoside resistance protein; Provisional; Region: PRK13746 418127005214 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 418127005215 active site 418127005216 NTP binding site [chemical binding]; other site 418127005217 metal binding triad [ion binding]; metal-binding site 418127005218 antibiotic binding site [chemical binding]; other site 418127005219 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 418127005220 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 418127005221 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 418127005222 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 418127005223 Int/Topo IB signature motif; other site 418127005224 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 418127005225 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 418127005226 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 418127005227 Int/Topo IB signature motif; other site 418127005228 hypothetical protein; Reviewed; Region: PRK00024 418127005229 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 418127005230 MPN+ (JAMM) motif; other site 418127005231 Zinc-binding site [ion binding]; other site 418127005232 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 418127005233 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 418127005234 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 418127005235 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 418127005236 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 418127005237 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 418127005238 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 418127005239 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 418127005240 active site 418127005241 HIGH motif; other site 418127005242 nucleotide binding site [chemical binding]; other site 418127005243 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 418127005244 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 418127005245 active site 418127005246 KMSKS motif; other site 418127005247 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 418127005248 tRNA binding surface [nucleotide binding]; other site 418127005249 anticodon binding site; other site 418127005250 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 418127005251 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 418127005252 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 418127005253 Putative ammonia monooxygenase; Region: AmoA; pfam05145 418127005254 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 418127005255 similar to hypothetical protein 418127005256 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 418127005257 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 418127005258 inhibitor-cofactor binding pocket; inhibition site 418127005259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127005260 catalytic residue [active] 418127005261 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 418127005262 dimer interface [polypeptide binding]; other site 418127005263 active site 418127005264 Schiff base residues; other site 418127005265 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 418127005266 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 418127005267 active site 418127005268 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 418127005269 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 418127005270 domain interfaces; other site 418127005271 active site 418127005272 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 418127005273 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 418127005274 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 418127005275 tRNA; other site 418127005276 putative tRNA binding site [nucleotide binding]; other site 418127005277 putative NADP binding site [chemical binding]; other site 418127005278 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 418127005279 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 418127005280 G1 box; other site 418127005281 GTP/Mg2+ binding site [chemical binding]; other site 418127005282 Switch I region; other site 418127005283 G2 box; other site 418127005284 G3 box; other site 418127005285 Switch II region; other site 418127005286 G4 box; other site 418127005287 G5 box; other site 418127005288 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 418127005289 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 418127005290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127005291 Walker A motif; other site 418127005292 ATP binding site [chemical binding]; other site 418127005293 Walker B motif; other site 418127005294 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 418127005295 trigger factor; Provisional; Region: tig; PRK01490 418127005296 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 418127005297 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 418127005298 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 418127005299 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 418127005300 23S rRNA binding site [nucleotide binding]; other site 418127005301 L21 binding site [polypeptide binding]; other site 418127005302 L13 binding site [polypeptide binding]; other site 418127005303 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 418127005304 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 418127005305 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 418127005306 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 418127005307 lysine transporter; Provisional; Region: PRK10836 418127005308 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 418127005309 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 418127005310 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 418127005311 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 418127005312 active site 418127005313 dimer interface [polypeptide binding]; other site 418127005314 motif 1; other site 418127005315 motif 2; other site 418127005316 motif 3; other site 418127005317 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 418127005318 anticodon binding site; other site 418127005319 primosomal protein DnaI; Reviewed; Region: PRK08939 418127005320 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 418127005321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127005322 Walker A motif; other site 418127005323 ATP binding site [chemical binding]; other site 418127005324 Walker B motif; other site 418127005325 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 418127005326 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 418127005327 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 418127005328 ATP cone domain; Region: ATP-cone; pfam03477 418127005329 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 418127005330 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 418127005331 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 418127005332 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 418127005333 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 418127005334 CoA-binding site [chemical binding]; other site 418127005335 ATP-binding [chemical binding]; other site 418127005336 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 418127005337 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 418127005338 DNA binding site [nucleotide binding] 418127005339 catalytic residue [active] 418127005340 H2TH interface [polypeptide binding]; other site 418127005341 putative catalytic residues [active] 418127005342 turnover-facilitating residue; other site 418127005343 intercalation triad [nucleotide binding]; other site 418127005344 8OG recognition residue [nucleotide binding]; other site 418127005345 putative reading head residues; other site 418127005346 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 418127005347 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 418127005348 DNA polymerase I; Provisional; Region: PRK05755 418127005349 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 418127005350 active site 418127005351 metal binding site 1 [ion binding]; metal-binding site 418127005352 putative 5' ssDNA interaction site; other site 418127005353 metal binding site 3; metal-binding site 418127005354 metal binding site 2 [ion binding]; metal-binding site 418127005355 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 418127005356 putative DNA binding site [nucleotide binding]; other site 418127005357 putative metal binding site [ion binding]; other site 418127005358 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 418127005359 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 418127005360 active site 418127005361 DNA binding site [nucleotide binding] 418127005362 catalytic site [active] 418127005363 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 418127005364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 418127005365 dimer interface [polypeptide binding]; other site 418127005366 phosphorylation site [posttranslational modification] 418127005367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127005368 ATP binding site [chemical binding]; other site 418127005369 Mg2+ binding site [ion binding]; other site 418127005370 G-X-G motif; other site 418127005371 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127005372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127005373 active site 418127005374 phosphorylation site [posttranslational modification] 418127005375 intermolecular recognition site; other site 418127005376 dimerization interface [polypeptide binding]; other site 418127005377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 418127005378 DNA binding site [nucleotide binding] 418127005379 isocitrate dehydrogenase; Reviewed; Region: PRK07006 418127005380 isocitrate dehydrogenase; Validated; Region: PRK07362 418127005381 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 418127005382 dimer interface [polypeptide binding]; other site 418127005383 Citrate synthase; Region: Citrate_synt; pfam00285 418127005384 active site 418127005385 citrylCoA binding site [chemical binding]; other site 418127005386 oxalacetate/citrate binding site [chemical binding]; other site 418127005387 coenzyme A binding site [chemical binding]; other site 418127005388 catalytic triad [active] 418127005389 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 418127005390 pyruvate kinase; Provisional; Region: PRK06354 418127005391 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 418127005392 domain interfaces; other site 418127005393 active site 418127005394 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 418127005395 6-phosphofructokinase; Provisional; Region: PRK03202 418127005396 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 418127005397 dimerization interface [polypeptide binding]; other site 418127005398 allosteric effector site; other site 418127005399 active site 418127005400 ADP/pyrophosphate binding site [chemical binding]; other site 418127005401 fructose-1,6-bisphosphate binding site; other site 418127005402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127005403 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127005404 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 418127005405 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 418127005406 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 418127005407 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 418127005408 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 418127005409 Malic enzyme, N-terminal domain; Region: malic; pfam00390 418127005410 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 418127005411 putative NAD(P) binding site [chemical binding]; other site 418127005412 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 418127005413 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 418127005414 active site 418127005415 PHP Thumb interface [polypeptide binding]; other site 418127005416 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 418127005417 generic binding surface I; other site 418127005418 generic binding surface II; other site 418127005419 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 418127005420 DHH family; Region: DHH; pfam01368 418127005421 DHHA1 domain; Region: DHHA1; pfam02272 418127005422 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 418127005423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 418127005424 DNA-binding site [nucleotide binding]; DNA binding site 418127005425 DRTGG domain; Region: DRTGG; pfam07085 418127005426 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 418127005427 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 418127005428 active site 2 [active] 418127005429 active site 1 [active] 418127005430 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 418127005431 Ligand Binding Site [chemical binding]; other site 418127005432 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 418127005433 metal-dependent hydrolase; Provisional; Region: PRK00685 418127005434 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 418127005435 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 418127005436 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 418127005437 active site 418127005438 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 418127005439 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 418127005440 hexamer interface [polypeptide binding]; other site 418127005441 ligand binding site [chemical binding]; other site 418127005442 putative active site [active] 418127005443 NAD(P) binding site [chemical binding]; other site 418127005444 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 418127005445 Ligand Binding Site [chemical binding]; other site 418127005446 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 418127005447 propionate/acetate kinase; Provisional; Region: PRK12379 418127005448 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 418127005449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127005450 S-adenosylmethionine binding site [chemical binding]; other site 418127005451 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 418127005452 dimer interface [polypeptide binding]; other site 418127005453 catalytic triad [active] 418127005454 peroxidatic and resolving cysteines [active] 418127005455 hypothetical protein; Provisional; Region: PRK10621 418127005456 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 418127005457 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 418127005458 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 418127005459 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 418127005460 Ligand Binding Site [chemical binding]; other site 418127005461 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 418127005462 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 418127005463 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127005464 catalytic residue [active] 418127005465 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 418127005466 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 418127005467 GAF domain; Region: GAF_2; pfam13185 418127005468 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 418127005469 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 418127005470 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 418127005471 RNA binding surface [nucleotide binding]; other site 418127005472 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127005473 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127005474 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 418127005475 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 418127005476 active site 418127005477 catalytic site [active] 418127005478 OsmC-like protein; Region: OsmC; cl00767 418127005479 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 418127005480 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127005481 catalytic residue [active] 418127005482 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 418127005483 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 418127005484 ligand binding site [chemical binding]; other site 418127005485 NAD binding site [chemical binding]; other site 418127005486 dimerization interface [polypeptide binding]; other site 418127005487 catalytic site [active] 418127005488 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 418127005489 putative L-serine binding site [chemical binding]; other site 418127005490 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 418127005491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127005492 motif II; other site 418127005493 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 418127005494 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 418127005495 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 418127005496 active site turn [active] 418127005497 phosphorylation site [posttranslational modification] 418127005498 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 418127005499 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 418127005500 putative acyl-acceptor binding pocket; other site 418127005501 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 418127005502 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 418127005503 protein binding site [polypeptide binding]; other site 418127005504 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 418127005505 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 418127005506 active site 418127005507 HIGH motif; other site 418127005508 dimer interface [polypeptide binding]; other site 418127005509 KMSKS motif; other site 418127005510 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 418127005511 RNA binding surface [nucleotide binding]; other site 418127005512 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 418127005513 Transglycosylase; Region: Transgly; pfam00912 418127005514 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 418127005515 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 418127005516 NEAr Transporter domain; Region: NEAT; smart00725 418127005517 NEAr Transporter domain; Region: NEAT; smart00725 418127005518 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 418127005519 heme-binding site [chemical binding]; other site 418127005520 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 418127005521 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 418127005522 Potassium binding sites [ion binding]; other site 418127005523 Cesium cation binding sites [ion binding]; other site 418127005524 acetyl-CoA synthetase; Provisional; Region: PRK04319 418127005525 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 418127005526 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 418127005527 active site 418127005528 acyl-activating enzyme (AAE) consensus motif; other site 418127005529 putative CoA binding site [chemical binding]; other site 418127005530 AMP binding site [chemical binding]; other site 418127005531 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 418127005532 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 418127005533 active site 418127005534 Zn binding site [ion binding]; other site 418127005535 catabolite control protein A; Region: ccpA; TIGR01481 418127005536 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 418127005537 DNA binding site [nucleotide binding] 418127005538 domain linker motif; other site 418127005539 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 418127005540 dimerization interface [polypeptide binding]; other site 418127005541 effector binding site; other site 418127005542 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 418127005543 Chorismate mutase type II; Region: CM_2; cl00693 418127005544 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 418127005545 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 418127005546 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 418127005547 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 418127005548 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 418127005549 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 418127005550 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 418127005551 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 418127005552 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 418127005553 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 418127005554 putative tRNA-binding site [nucleotide binding]; other site 418127005555 hypothetical protein; Provisional; Region: PRK13668 418127005556 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 418127005557 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 418127005558 catalytic residues [active] 418127005559 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 418127005560 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 418127005561 oligomer interface [polypeptide binding]; other site 418127005562 active site 418127005563 metal binding site [ion binding]; metal-binding site 418127005564 Predicted small secreted protein [Function unknown]; Region: COG5584 418127005565 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 418127005566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127005567 S-adenosylmethionine binding site [chemical binding]; other site 418127005568 Phosphotransferase enzyme family; Region: APH; pfam01636 418127005569 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 418127005570 active site 418127005571 substrate binding site [chemical binding]; other site 418127005572 ATP binding site [chemical binding]; other site 418127005573 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 418127005574 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 418127005575 homodimer interface [polypeptide binding]; other site 418127005576 substrate-cofactor binding pocket; other site 418127005577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127005578 catalytic residue [active] 418127005579 dipeptidase PepV; Reviewed; Region: PRK07318 418127005580 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 418127005581 active site 418127005582 metal binding site [ion binding]; metal-binding site 418127005583 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 418127005584 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 418127005585 RNA binding surface [nucleotide binding]; other site 418127005586 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 418127005587 active site 418127005588 uracil binding [chemical binding]; other site 418127005589 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 418127005590 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 418127005591 HI0933-like protein; Region: HI0933_like; pfam03486 418127005592 Predicted flavoproteins [General function prediction only]; Region: COG2081 418127005593 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 418127005594 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 418127005595 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 418127005596 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005597 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005598 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005599 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005600 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005601 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005602 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005603 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005604 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005605 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005606 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005607 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005608 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005609 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005610 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005611 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 418127005612 active site residue [active] 418127005613 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 418127005614 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 418127005615 HIGH motif; other site 418127005616 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 418127005617 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 418127005618 active site 418127005619 KMSKS motif; other site 418127005620 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 418127005621 tRNA binding surface [nucleotide binding]; other site 418127005622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127005623 Major Facilitator Superfamily; Region: MFS_1; pfam07690 418127005624 putative substrate translocation pore; other site 418127005625 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 418127005626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127005627 S-adenosylmethionine binding site [chemical binding]; other site 418127005628 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 418127005629 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 418127005630 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 418127005631 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 418127005632 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 418127005633 homopentamer interface [polypeptide binding]; other site 418127005634 active site 418127005635 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 418127005636 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 418127005637 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 418127005638 dimerization interface [polypeptide binding]; other site 418127005639 active site 418127005640 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 418127005641 Lumazine binding domain; Region: Lum_binding; pfam00677 418127005642 Lumazine binding domain; Region: Lum_binding; pfam00677 418127005643 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 418127005644 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 418127005645 catalytic motif [active] 418127005646 Zn binding site [ion binding]; other site 418127005647 RibD C-terminal domain; Region: RibD_C; cl17279 418127005648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 418127005649 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 418127005650 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 418127005651 dimerization interface [polypeptide binding]; other site 418127005652 putative DNA binding site [nucleotide binding]; other site 418127005653 putative Zn2+ binding site [ion binding]; other site 418127005654 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 418127005655 arsenical pump membrane protein; Provisional; Region: PRK15445 418127005656 transmembrane helices; other site 418127005657 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 418127005658 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 418127005659 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 418127005660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 418127005661 DNA binding residues [nucleotide binding] 418127005662 CAAX protease self-immunity; Region: Abi; pfam02517 418127005663 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 418127005664 active site 418127005665 intersubunit interactions; other site 418127005666 catalytic residue [active] 418127005667 camphor resistance protein CrcB; Provisional; Region: PRK14201 418127005668 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 418127005669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 418127005670 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 418127005671 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 418127005672 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 418127005673 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 418127005674 active site 418127005675 catalytic tetrad [active] 418127005676 S-adenosylmethionine synthetase; Validated; Region: PRK05250 418127005677 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 418127005678 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 418127005679 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 418127005680 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 418127005681 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 418127005682 active site 418127005683 substrate-binding site [chemical binding]; other site 418127005684 metal-binding site [ion binding] 418127005685 ATP binding site [chemical binding]; other site 418127005686 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 418127005687 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 418127005688 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 418127005689 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 418127005690 nudix motif; other site 418127005691 Haemolytic domain; Region: Haemolytic; pfam01809 418127005692 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 418127005693 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 418127005694 metal binding site [ion binding]; metal-binding site 418127005695 substrate binding pocket [chemical binding]; other site 418127005696 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 418127005697 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 418127005698 acyl-activating enzyme (AAE) consensus motif; other site 418127005699 putative AMP binding site [chemical binding]; other site 418127005700 putative active site [active] 418127005701 putative CoA binding site [chemical binding]; other site 418127005702 Excalibur calcium-binding domain; Region: Excalibur; smart00894 418127005703 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 418127005704 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 418127005705 Integrase core domain; Region: rve; pfam00665 418127005706 DDE domain; Region: DDE_Tnp_IS240; pfam13610 418127005707 Integrase core domain; Region: rve_3; pfam13683 418127005708 putative transposase OrfB; Reviewed; Region: PHA02517 418127005709 Winged helix-turn helix; Region: HTH_29; pfam13551 418127005710 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 418127005711 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 418127005712 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 418127005713 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 418127005714 HsdM N-terminal domain; Region: HsdM_N; pfam12161 418127005715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127005716 S-adenosylmethionine binding site [chemical binding]; other site 418127005717 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 418127005718 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 418127005719 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 418127005720 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 418127005721 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 418127005722 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 418127005723 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 418127005724 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 418127005725 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 418127005726 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 418127005727 beta-channel forming cytolysin; Region: hlyII; TIGR01002 418127005728 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 418127005729 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 418127005730 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 418127005731 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 418127005732 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 418127005733 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005734 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005735 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005736 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005737 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005738 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005739 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005740 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005741 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005742 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005743 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005744 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005745 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 418127005746 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 418127005747 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 418127005748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 418127005749 ferrochelatase; Provisional; Region: PRK12435 418127005750 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 418127005751 C-terminal domain interface [polypeptide binding]; other site 418127005752 active site 418127005753 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 418127005754 active site 418127005755 N-terminal domain interface [polypeptide binding]; other site 418127005756 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 418127005757 substrate binding site [chemical binding]; other site 418127005758 active site 418127005759 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 418127005760 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 418127005761 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 418127005762 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 418127005763 Walker A/P-loop; other site 418127005764 ATP binding site [chemical binding]; other site 418127005765 Q-loop/lid; other site 418127005766 ABC transporter signature motif; other site 418127005767 Walker B; other site 418127005768 D-loop; other site 418127005769 H-loop/switch region; other site 418127005770 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 418127005771 HIT family signature motif; other site 418127005772 catalytic residue [active] 418127005773 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 418127005774 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 418127005775 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 418127005776 SurA N-terminal domain; Region: SurA_N_3; cl07813 418127005777 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 418127005778 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 418127005779 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 418127005780 generic binding surface II; other site 418127005781 generic binding surface I; other site 418127005782 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 418127005783 Zn2+ binding site [ion binding]; other site 418127005784 Mg2+ binding site [ion binding]; other site 418127005785 Uncharacterized conserved protein [Function unknown]; Region: COG4717 418127005786 P-loop containing region of AAA domain; Region: AAA_29; cl17516 418127005787 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 418127005788 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 418127005789 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 418127005790 active site 418127005791 metal binding site [ion binding]; metal-binding site 418127005792 DNA binding site [nucleotide binding] 418127005793 hypothetical protein; Provisional; Region: PRK13676 418127005794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 418127005795 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 418127005796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127005797 non-specific DNA binding site [nucleotide binding]; other site 418127005798 salt bridge; other site 418127005799 sequence-specific DNA binding site [nucleotide binding]; other site 418127005800 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 418127005801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127005802 active site 418127005803 phosphorylation site [posttranslational modification] 418127005804 intermolecular recognition site; other site 418127005805 dimerization interface [polypeptide binding]; other site 418127005806 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 418127005807 DNA binding residues [nucleotide binding] 418127005808 dimerization interface [polypeptide binding]; other site 418127005809 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 418127005810 GAF domain; Region: GAF_3; pfam13492 418127005811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 418127005812 Histidine kinase; Region: HisKA_3; pfam07730 418127005813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127005814 ATP binding site [chemical binding]; other site 418127005815 Mg2+ binding site [ion binding]; other site 418127005816 G-X-G motif; other site 418127005817 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 418127005818 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 418127005819 active site 418127005820 fumarate hydratase; Reviewed; Region: fumC; PRK00485 418127005821 Class II fumarases; Region: Fumarase_classII; cd01362 418127005822 active site 418127005823 tetramer interface [polypeptide binding]; other site 418127005824 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 418127005825 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 418127005826 active site 418127005827 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 418127005828 epoxyqueuosine reductase; Region: TIGR00276 418127005829 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 418127005830 HEAT repeats; Region: HEAT_2; pfam13646 418127005831 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 418127005832 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 418127005833 Walker A/P-loop; other site 418127005834 ATP binding site [chemical binding]; other site 418127005835 Q-loop/lid; other site 418127005836 ABC transporter signature motif; other site 418127005837 Walker B; other site 418127005838 D-loop; other site 418127005839 H-loop/switch region; other site 418127005840 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 418127005841 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 418127005842 substrate binding pocket [chemical binding]; other site 418127005843 membrane-bound complex binding site; other site 418127005844 hinge residues; other site 418127005845 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 418127005846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127005847 dimer interface [polypeptide binding]; other site 418127005848 conserved gate region; other site 418127005849 putative PBP binding loops; other site 418127005850 ABC-ATPase subunit interface; other site 418127005851 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 418127005852 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 418127005853 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127005854 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127005855 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 418127005856 metal binding site 2 [ion binding]; metal-binding site 418127005857 putative DNA binding helix; other site 418127005858 metal binding site 1 [ion binding]; metal-binding site 418127005859 dimer interface [polypeptide binding]; other site 418127005860 structural Zn2+ binding site [ion binding]; other site 418127005861 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 418127005862 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 418127005863 putative ligand binding site [chemical binding]; other site 418127005864 NAD binding site [chemical binding]; other site 418127005865 catalytic site [active] 418127005866 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 418127005867 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 418127005868 catalytic triad [active] 418127005869 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 418127005870 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 418127005871 inhibitor-cofactor binding pocket; inhibition site 418127005872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127005873 catalytic residue [active] 418127005874 Predicted membrane protein [Function unknown]; Region: COG4129 418127005875 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 418127005876 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 418127005877 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 418127005878 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 418127005879 Walker A/P-loop; other site 418127005880 ATP binding site [chemical binding]; other site 418127005881 Q-loop/lid; other site 418127005882 ABC transporter signature motif; other site 418127005883 Walker B; other site 418127005884 D-loop; other site 418127005885 H-loop/switch region; other site 418127005886 hypothetical protein; Provisional; Region: PRK13662 418127005887 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 418127005888 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 418127005889 minor groove reading motif; other site 418127005890 helix-hairpin-helix signature motif; other site 418127005891 substrate binding pocket [chemical binding]; other site 418127005892 active site 418127005893 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 418127005894 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 418127005895 DNA binding and oxoG recognition site [nucleotide binding] 418127005896 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 418127005897 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 418127005898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 418127005899 Walker A/P-loop; other site 418127005900 ATP binding site [chemical binding]; other site 418127005901 Q-loop/lid; other site 418127005902 ABC transporter signature motif; other site 418127005903 Walker B; other site 418127005904 H-loop/switch region; other site 418127005905 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 418127005906 recombination regulator RecX; Provisional; Region: recX; PRK14135 418127005907 glycosyltransferase; Provisional; Region: PRK13481 418127005908 Transglycosylase; Region: Transgly; pfam00912 418127005909 intracellular protease, PfpI family; Region: PfpI; TIGR01382 418127005910 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 418127005911 proposed catalytic triad [active] 418127005912 conserved cys residue [active] 418127005913 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 418127005914 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 418127005915 FeS/SAM binding site; other site 418127005916 YfkB-like domain; Region: YfkB; pfam08756 418127005917 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 418127005918 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 418127005919 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 418127005920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 418127005921 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 418127005922 Low molecular weight phosphatase family; Region: LMWPc; cd00115 418127005923 active site 418127005924 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 418127005925 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 418127005926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127005927 active site 418127005928 phosphorylation site [posttranslational modification] 418127005929 intermolecular recognition site; other site 418127005930 dimerization interface [polypeptide binding]; other site 418127005931 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 418127005932 DNA binding residues [nucleotide binding] 418127005933 dimerization interface [polypeptide binding]; other site 418127005934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 418127005935 Histidine kinase; Region: HisKA_3; pfam07730 418127005936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127005937 ATP binding site [chemical binding]; other site 418127005938 Mg2+ binding site [ion binding]; other site 418127005939 G-X-G motif; other site 418127005940 Predicted membrane protein [Function unknown]; Region: COG4758 418127005941 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 418127005942 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 418127005943 active site 418127005944 Predicted membrane protein [Function unknown]; Region: COG4129 418127005945 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 418127005946 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 418127005947 catalytic triad [active] 418127005948 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 418127005949 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 418127005950 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 418127005951 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 418127005952 Ferritin-like domain; Region: Ferritin; pfam00210 418127005953 ferroxidase diiron center [ion binding]; other site 418127005954 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 418127005955 active site 418127005956 catalytic site [active] 418127005957 substrate binding site [chemical binding]; other site 418127005958 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 418127005959 active site 418127005960 DNA polymerase IV; Validated; Region: PRK02406 418127005961 DNA binding site [nucleotide binding] 418127005962 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 418127005963 TRAM domain; Region: TRAM; cl01282 418127005964 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 418127005965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127005966 S-adenosylmethionine binding site [chemical binding]; other site 418127005967 putative lipid kinase; Reviewed; Region: PRK13337 418127005968 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 418127005969 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 418127005970 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 418127005971 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 418127005972 GatB domain; Region: GatB_Yqey; pfam02637 418127005973 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 418127005974 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 418127005975 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 418127005976 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 418127005977 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 418127005978 Na binding site [ion binding]; other site 418127005979 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 418127005980 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 418127005981 putative dimer interface [polypeptide binding]; other site 418127005982 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 418127005983 putative dimer interface [polypeptide binding]; other site 418127005984 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 418127005985 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 418127005986 nucleotide binding pocket [chemical binding]; other site 418127005987 K-X-D-G motif; other site 418127005988 catalytic site [active] 418127005989 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 418127005990 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 418127005991 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 418127005992 Dimer interface [polypeptide binding]; other site 418127005993 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 418127005994 Part of AAA domain; Region: AAA_19; pfam13245 418127005995 Family description; Region: UvrD_C_2; pfam13538 418127005996 PcrB family; Region: PcrB; pfam01884 418127005997 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 418127005998 substrate binding site [chemical binding]; other site 418127005999 putative active site [active] 418127006000 dimer interface [polypeptide binding]; other site 418127006001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 418127006002 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 418127006003 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 418127006004 tetramer interface [polypeptide binding]; other site 418127006005 active site 418127006006 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 418127006007 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 418127006008 Staphostatin A; Region: Staphostatin_A; pfam09022 418127006009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 418127006010 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 418127006011 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 418127006012 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 418127006013 homodimer interface [polypeptide binding]; other site 418127006014 NAD binding pocket [chemical binding]; other site 418127006015 ATP binding pocket [chemical binding]; other site 418127006016 Mg binding site [ion binding]; other site 418127006017 active-site loop [active] 418127006018 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 418127006019 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 418127006020 active site 418127006021 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 418127006022 active site 418127006023 dimer interface [polypeptide binding]; other site 418127006024 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 418127006025 Prephenate dehydratase; Region: PDT; pfam00800 418127006026 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 418127006027 putative L-Phe binding site [chemical binding]; other site 418127006028 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 418127006029 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 418127006030 transmembrane helices; other site 418127006031 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 418127006032 Isochorismatase family; Region: Isochorismatase; pfam00857 418127006033 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 418127006034 catalytic triad [active] 418127006035 conserved cis-peptide bond; other site 418127006036 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 418127006037 DHH family; Region: DHH; pfam01368 418127006038 DHHA2 domain; Region: DHHA2; pfam02833 418127006039 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 418127006040 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 418127006041 NAD(P) binding site [chemical binding]; other site 418127006042 catalytic residues [active] 418127006043 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 418127006044 YolD-like protein; Region: YolD; pfam08863 418127006045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 418127006046 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 418127006047 active site 418127006048 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 418127006049 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 418127006050 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 418127006051 Bacterial PH domain; Region: DUF304; cl01348 418127006052 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 418127006053 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 418127006054 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 418127006055 Walker A/P-loop; other site 418127006056 ATP binding site [chemical binding]; other site 418127006057 Q-loop/lid; other site 418127006058 ABC transporter signature motif; other site 418127006059 Walker B; other site 418127006060 D-loop; other site 418127006061 H-loop/switch region; other site 418127006062 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 418127006063 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 418127006064 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 418127006065 Walker A/P-loop; other site 418127006066 ATP binding site [chemical binding]; other site 418127006067 Q-loop/lid; other site 418127006068 ABC transporter signature motif; other site 418127006069 Walker B; other site 418127006070 D-loop; other site 418127006071 H-loop/switch region; other site 418127006072 Predicted transcriptional regulators [Transcription]; Region: COG1725 418127006073 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 418127006074 DNA-binding site [nucleotide binding]; DNA binding site 418127006075 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 418127006076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 418127006077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127006078 homodimer interface [polypeptide binding]; other site 418127006079 catalytic residue [active] 418127006080 MAP domain; Region: MAP; pfam03642 418127006081 MAP domain; Region: MAP; pfam03642 418127006082 MAP domain; Region: MAP; pfam03642 418127006083 MAP domain; Region: MAP; pfam03642 418127006084 MAP domain; Region: MAP; pfam03642 418127006085 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 418127006086 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 418127006087 Bacterial SH3 domain homologues; Region: SH3b; smart00287 418127006088 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 418127006089 CHAP domain; Region: CHAP; pfam05257 418127006090 Small integral membrane protein [Function unknown]; Region: COG5546 418127006091 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127006092 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127006093 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 418127006094 Ligand-gated ion channel; Region: Lig_chan; pfam00060 418127006095 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 418127006096 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 418127006097 Phage tail protein; Region: Sipho_tail; cl17486 418127006098 Phage tail protein; Region: Sipho_tail; cl17486 418127006099 Phage-related minor tail protein [Function unknown]; Region: COG5280 418127006100 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 418127006101 Phage-related protein [Function unknown]; Region: COG5412 418127006102 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 418127006103 Peptidase family M23; Region: Peptidase_M23; pfam01551 418127006104 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 418127006105 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 418127006106 N-acetyl-D-glucosamine binding site [chemical binding]; other site 418127006107 catalytic residue [active] 418127006108 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 418127006109 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 418127006110 Translocation protein Sec62; Region: Sec62; cl02170 418127006111 Phage capsid family; Region: Phage_capsid; pfam05065 418127006112 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 418127006113 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 418127006114 oligomer interface [polypeptide binding]; other site 418127006115 active site residues [active] 418127006116 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 418127006117 Phage-related protein [Function unknown]; Region: COG4695; cl01923 418127006118 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 418127006119 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 418127006120 HNH endonuclease; Region: HNH; pfam01844 418127006121 active site 418127006122 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 418127006123 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 418127006124 Transcriptional activator RinB; Region: RinB; pfam06116 418127006125 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 418127006126 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 418127006127 trimer interface [polypeptide binding]; other site 418127006128 active site 418127006129 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 418127006130 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 418127006131 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 418127006132 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 418127006133 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 418127006134 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 418127006135 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 418127006136 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 418127006137 dimer interface [polypeptide binding]; other site 418127006138 ssDNA binding site [nucleotide binding]; other site 418127006139 tetramer (dimer of dimers) interface [polypeptide binding]; other site 418127006140 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 418127006141 RecT family; Region: RecT; pfam03837 418127006142 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 418127006143 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 418127006144 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 418127006145 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 418127006146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 418127006147 Phage anti-repressor protein [Transcription]; Region: COG3561 418127006148 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 418127006149 Protein of unknown function (DUF739); Region: DUF739; pfam05339 418127006150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127006151 non-specific DNA binding site [nucleotide binding]; other site 418127006152 salt bridge; other site 418127006153 sequence-specific DNA binding site [nucleotide binding]; other site 418127006154 Predicted transcriptional regulator [Transcription]; Region: COG2932 418127006155 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 418127006156 Catalytic site [active] 418127006157 HIRAN domain; Region: HIRAN; pfam08797 418127006158 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 418127006159 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 418127006160 Int/Topo IB signature motif; other site 418127006161 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 418127006162 putative catalytic site [active] 418127006163 phosphate binding site [ion binding]; other site 418127006164 metal binding site A [ion binding]; metal-binding site 418127006165 metal binding site C [ion binding]; metal-binding site 418127006166 metal binding site B [ion binding]; metal-binding site 418127006167 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 418127006168 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 418127006169 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 418127006170 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 418127006171 metal binding site [ion binding]; metal-binding site 418127006172 dimer interface [polypeptide binding]; other site 418127006173 Cation transport protein; Region: TrkH; cl17365 418127006174 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 418127006175 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127006176 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127006177 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127006178 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127006179 superantigen-like protein; Reviewed; Region: PRK13350 418127006180 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127006181 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127006182 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 418127006183 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 418127006184 hydrolase, hydrolyzing O-glycosyl compounds; Region: PLN02219; cl14104 418127006185 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 418127006186 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 418127006187 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 418127006188 DNA binding domain, excisionase family; Region: excise; TIGR01764 418127006189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127006190 non-specific DNA binding site [nucleotide binding]; other site 418127006191 salt bridge; other site 418127006192 sequence-specific DNA binding site [nucleotide binding]; other site 418127006193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127006194 non-specific DNA binding site [nucleotide binding]; other site 418127006195 salt bridge; other site 418127006196 sequence-specific DNA binding site [nucleotide binding]; other site 418127006197 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 418127006198 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 418127006199 Int/Topo IB signature motif; other site 418127006200 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 418127006201 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 418127006202 ring oligomerisation interface [polypeptide binding]; other site 418127006203 ATP/Mg binding site [chemical binding]; other site 418127006204 stacking interactions; other site 418127006205 hinge regions; other site 418127006206 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 418127006207 oligomerisation interface [polypeptide binding]; other site 418127006208 mobile loop; other site 418127006209 roof hairpin; other site 418127006210 CAAX protease self-immunity; Region: Abi; pfam02517 418127006211 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 418127006212 dimer interface [polypeptide binding]; other site 418127006213 FMN binding site [chemical binding]; other site 418127006214 Predicted amidohydrolase [General function prediction only]; Region: COG0388 418127006215 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 418127006216 putative active site [active] 418127006217 catalytic triad [active] 418127006218 putative dimer interface [polypeptide binding]; other site 418127006219 delta-hemolysin; Provisional; Region: PRK14752 418127006220 Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription]; Region: AgrB; COG4512 418127006221 Staphylococcal AgrD protein; Region: AgrD; pfam05931 418127006222 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 418127006223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127006224 Mg2+ binding site [ion binding]; other site 418127006225 G-X-G motif; other site 418127006226 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 418127006227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127006228 active site 418127006229 phosphorylation site [posttranslational modification] 418127006230 intermolecular recognition site; other site 418127006231 dimerization interface [polypeptide binding]; other site 418127006232 LytTr DNA-binding domain; Region: LytTR; pfam04397 418127006233 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 418127006234 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 418127006235 putative substrate binding site [chemical binding]; other site 418127006236 putative ATP binding site [chemical binding]; other site 418127006237 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 418127006238 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 418127006239 substrate binding [chemical binding]; other site 418127006240 active site 418127006241 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 418127006242 Transcriptional regulators [Transcription]; Region: PurR; COG1609 418127006243 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 418127006244 DNA binding site [nucleotide binding] 418127006245 domain linker motif; other site 418127006246 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 418127006247 dimerization interface [polypeptide binding]; other site 418127006248 ligand binding site [chemical binding]; other site 418127006249 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 418127006250 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 418127006251 CPxP motif; other site 418127006252 Predicted transporter component [General function prediction only]; Region: COG2391 418127006253 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 418127006254 Sulphur transport; Region: Sulf_transp; pfam04143 418127006255 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 418127006256 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 418127006257 CoA binding domain; Region: CoA_binding; pfam02629 418127006258 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 418127006259 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 418127006260 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 418127006261 ABC transporter; Region: ABC_tran_2; pfam12848 418127006262 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 418127006263 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 418127006264 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 418127006265 Walker A/P-loop; other site 418127006266 ATP binding site [chemical binding]; other site 418127006267 Q-loop/lid; other site 418127006268 ABC transporter signature motif; other site 418127006269 Walker B; other site 418127006270 D-loop; other site 418127006271 H-loop/switch region; other site 418127006272 UGMP family protein; Validated; Region: PRK09604 418127006273 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 418127006274 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 418127006275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127006276 Coenzyme A binding pocket [chemical binding]; other site 418127006277 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 418127006278 Glycoprotease family; Region: Peptidase_M22; pfam00814 418127006279 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 418127006280 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 418127006281 6-phosphogluconate dehydratase; Region: edd; TIGR01196 418127006282 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 418127006283 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 418127006284 PYR/PP interface [polypeptide binding]; other site 418127006285 dimer interface [polypeptide binding]; other site 418127006286 TPP binding site [chemical binding]; other site 418127006287 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 418127006288 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 418127006289 TPP-binding site [chemical binding]; other site 418127006290 dimer interface [polypeptide binding]; other site 418127006291 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 418127006292 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 418127006293 ketol-acid reductoisomerase; Provisional; Region: PRK05479 418127006294 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 418127006295 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 418127006296 2-isopropylmalate synthase; Validated; Region: PRK00915 418127006297 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 418127006298 active site 418127006299 catalytic residues [active] 418127006300 metal binding site [ion binding]; metal-binding site 418127006301 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 418127006302 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 418127006303 tartrate dehydrogenase; Region: TTC; TIGR02089 418127006304 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 418127006305 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 418127006306 substrate binding site [chemical binding]; other site 418127006307 ligand binding site [chemical binding]; other site 418127006308 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 418127006309 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 418127006310 substrate binding site [chemical binding]; other site 418127006311 threonine dehydratase; Validated; Region: PRK08639 418127006312 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 418127006313 tetramer interface [polypeptide binding]; other site 418127006314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127006315 catalytic residue [active] 418127006316 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 418127006317 putative Ile/Val binding site [chemical binding]; other site 418127006318 hypothetical protein; Provisional; Region: PRK04351 418127006319 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 418127006320 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 418127006321 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 418127006322 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 418127006323 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 418127006324 RNA binding site [nucleotide binding]; other site 418127006325 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 418127006326 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 418127006327 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 418127006328 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 418127006329 DNA binding residues [nucleotide binding] 418127006330 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 418127006331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127006332 ATP binding site [chemical binding]; other site 418127006333 Mg2+ binding site [ion binding]; other site 418127006334 G-X-G motif; other site 418127006335 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 418127006336 anti sigma factor interaction site; other site 418127006337 regulatory phosphorylation site [posttranslational modification]; other site 418127006338 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 418127006339 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 418127006340 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 418127006341 PemK-like protein; Region: PemK; pfam02452 418127006342 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 418127006343 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 418127006344 active site 418127006345 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 418127006346 dimer interface [polypeptide binding]; other site 418127006347 substrate binding site [chemical binding]; other site 418127006348 catalytic residues [active] 418127006349 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 418127006350 Uncharacterized conserved protein [Function unknown]; Region: COG3402 418127006351 Predicted membrane protein [Function unknown]; Region: COG3428 418127006352 Bacterial PH domain; Region: DUF304; pfam03703 418127006353 Bacterial PH domain; Region: DUF304; pfam03703 418127006354 Bacterial PH domain; Region: DUF304; cl01348 418127006355 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 418127006356 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 418127006357 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 418127006358 Soluble P-type ATPase [General function prediction only]; Region: COG4087 418127006359 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 418127006360 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 418127006361 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 418127006362 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 418127006363 Ligand Binding Site [chemical binding]; other site 418127006364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 418127006365 dimer interface [polypeptide binding]; other site 418127006366 phosphorylation site [posttranslational modification] 418127006367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127006368 ATP binding site [chemical binding]; other site 418127006369 Mg2+ binding site [ion binding]; other site 418127006370 G-X-G motif; other site 418127006371 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127006372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127006373 active site 418127006374 phosphorylation site [posttranslational modification] 418127006375 intermolecular recognition site; other site 418127006376 dimerization interface [polypeptide binding]; other site 418127006377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 418127006378 DNA binding site [nucleotide binding] 418127006379 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127006380 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127006381 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 418127006382 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 418127006383 ATP binding site [chemical binding]; other site 418127006384 Mg++ binding site [ion binding]; other site 418127006385 motif III; other site 418127006386 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127006387 nucleotide binding region [chemical binding]; other site 418127006388 ATP-binding site [chemical binding]; other site 418127006389 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 418127006390 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 418127006391 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 418127006392 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 418127006393 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 418127006394 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 418127006395 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 418127006396 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 418127006397 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 418127006398 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 418127006399 putative homodimer interface [polypeptide binding]; other site 418127006400 putative homotetramer interface [polypeptide binding]; other site 418127006401 allosteric switch controlling residues; other site 418127006402 putative metal binding site [ion binding]; other site 418127006403 putative homodimer-homodimer interface [polypeptide binding]; other site 418127006404 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 418127006405 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 418127006406 putative active site [active] 418127006407 catalytic site [active] 418127006408 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 418127006409 putative active site [active] 418127006410 catalytic site [active] 418127006411 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 418127006412 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 418127006413 Zn2+ binding site [ion binding]; other site 418127006414 Mg2+ binding site [ion binding]; other site 418127006415 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 418127006416 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 418127006417 thiamine phosphate binding site [chemical binding]; other site 418127006418 active site 418127006419 pyrophosphate binding site [ion binding]; other site 418127006420 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 418127006421 substrate binding site [chemical binding]; other site 418127006422 multimerization interface [polypeptide binding]; other site 418127006423 ATP binding site [chemical binding]; other site 418127006424 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 418127006425 dimer interface [polypeptide binding]; other site 418127006426 substrate binding site [chemical binding]; other site 418127006427 ATP binding site [chemical binding]; other site 418127006428 thiaminase II; Region: salvage_TenA; TIGR04306 418127006429 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 418127006430 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 418127006431 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 418127006432 dimer interface [polypeptide binding]; other site 418127006433 ssDNA binding site [nucleotide binding]; other site 418127006434 tetramer (dimer of dimers) interface [polypeptide binding]; other site 418127006435 YwpF-like protein; Region: YwpF; pfam14183 418127006436 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 418127006437 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 418127006438 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 418127006439 hinge; other site 418127006440 active site 418127006441 Predicted membrane protein [Function unknown]; Region: COG4836 418127006442 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 418127006443 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 418127006444 gamma subunit interface [polypeptide binding]; other site 418127006445 epsilon subunit interface [polypeptide binding]; other site 418127006446 LBP interface [polypeptide binding]; other site 418127006447 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 418127006448 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 418127006449 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 418127006450 alpha subunit interaction interface [polypeptide binding]; other site 418127006451 Walker A motif; other site 418127006452 ATP binding site [chemical binding]; other site 418127006453 Walker B motif; other site 418127006454 inhibitor binding site; inhibition site 418127006455 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 418127006456 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 418127006457 core domain interface [polypeptide binding]; other site 418127006458 delta subunit interface [polypeptide binding]; other site 418127006459 epsilon subunit interface [polypeptide binding]; other site 418127006460 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 418127006461 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 418127006462 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 418127006463 beta subunit interaction interface [polypeptide binding]; other site 418127006464 Walker A motif; other site 418127006465 ATP binding site [chemical binding]; other site 418127006466 Walker B motif; other site 418127006467 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 418127006468 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 418127006469 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 418127006470 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 418127006471 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 418127006472 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 418127006473 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 418127006474 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 418127006475 Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468 418127006476 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 418127006477 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 418127006478 active site 418127006479 homodimer interface [polypeptide binding]; other site 418127006480 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 418127006481 active site 418127006482 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 418127006483 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 418127006484 dimer interface [polypeptide binding]; other site 418127006485 active site 418127006486 glycine-pyridoxal phosphate binding site [chemical binding]; other site 418127006487 folate binding site [chemical binding]; other site 418127006488 hypothetical protein; Provisional; Region: PRK13690 418127006489 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 418127006490 Low molecular weight phosphatase family; Region: LMWPc; cd00115 418127006491 active site 418127006492 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 418127006493 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 418127006494 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 418127006495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127006496 S-adenosylmethionine binding site [chemical binding]; other site 418127006497 peptide chain release factor 1; Validated; Region: prfA; PRK00591 418127006498 This domain is found in peptide chain release factors; Region: PCRF; smart00937 418127006499 RF-1 domain; Region: RF-1; pfam00472 418127006500 thymidine kinase; Provisional; Region: PRK04296 418127006501 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 418127006502 transcription termination factor Rho; Provisional; Region: rho; PRK09376 418127006503 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 418127006504 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 418127006505 RNA binding site [nucleotide binding]; other site 418127006506 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 418127006507 multimer interface [polypeptide binding]; other site 418127006508 Walker A motif; other site 418127006509 ATP binding site [chemical binding]; other site 418127006510 Walker B motif; other site 418127006511 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 418127006512 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 418127006513 NAD binding site [chemical binding]; other site 418127006514 catalytic residues [active] 418127006515 Predicted transcriptional regulators [Transcription]; Region: COG1733 418127006516 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 418127006517 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 418127006518 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 418127006519 hinge; other site 418127006520 active site 418127006521 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 418127006522 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 418127006523 intersubunit interface [polypeptide binding]; other site 418127006524 active site 418127006525 zinc binding site [ion binding]; other site 418127006526 Na+ binding site [ion binding]; other site 418127006527 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 418127006528 CTP synthetase; Validated; Region: pyrG; PRK05380 418127006529 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 418127006530 Catalytic site [active] 418127006531 active site 418127006532 UTP binding site [chemical binding]; other site 418127006533 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 418127006534 active site 418127006535 putative oxyanion hole; other site 418127006536 catalytic triad [active] 418127006537 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 418127006538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127006539 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 418127006540 Coenzyme A binding pocket [chemical binding]; other site 418127006541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 418127006542 Coenzyme A binding pocket [chemical binding]; other site 418127006543 pantothenate kinase; Provisional; Region: PRK13317 418127006544 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 418127006545 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 418127006546 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 418127006547 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 418127006548 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 418127006549 metal binding site [ion binding]; metal-binding site 418127006550 S-ribosylhomocysteinase; Provisional; Region: PRK02260 418127006551 Predicted membrane protein [Function unknown]; Region: COG4270 418127006552 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 418127006553 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 418127006554 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 418127006555 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 418127006556 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 418127006557 intersubunit interface [polypeptide binding]; other site 418127006558 active site 418127006559 catalytic residue [active] 418127006560 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 418127006561 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 418127006562 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 418127006563 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 418127006564 dimerization interface [polypeptide binding]; other site 418127006565 DPS ferroxidase diiron center [ion binding]; other site 418127006566 ion pore; other site 418127006567 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 418127006568 EVE domain; Region: EVE; cl00728 418127006569 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 418127006570 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 418127006571 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 418127006572 NADH(P)-binding; Region: NAD_binding_10; pfam13460 418127006573 NAD(P) binding site [chemical binding]; other site 418127006574 putative active site [active] 418127006575 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 418127006576 dimerization interface [polypeptide binding]; other site 418127006577 putative DNA binding site [nucleotide binding]; other site 418127006578 putative Zn2+ binding site [ion binding]; other site 418127006579 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 418127006580 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 418127006581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 418127006582 Cytoadherence-linked asexual protein; Region: CLAG; pfam03805 418127006583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 418127006584 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 418127006585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127006586 active site 418127006587 motif I; other site 418127006588 motif II; other site 418127006589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127006590 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 418127006591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 418127006592 Walker A/P-loop; other site 418127006593 ATP binding site [chemical binding]; other site 418127006594 Q-loop/lid; other site 418127006595 ABC transporter signature motif; other site 418127006596 Walker B; other site 418127006597 D-loop; other site 418127006598 H-loop/switch region; other site 418127006599 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 418127006600 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 418127006601 glutaminase active site [active] 418127006602 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 418127006603 dimer interface [polypeptide binding]; other site 418127006604 active site 418127006605 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 418127006606 dimer interface [polypeptide binding]; other site 418127006607 active site 418127006608 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 418127006609 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 418127006610 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 418127006611 active site 418127006612 P-loop; other site 418127006613 phosphorylation site [posttranslational modification] 418127006614 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 418127006615 HTH domain; Region: HTH_11; pfam08279 418127006616 Mga helix-turn-helix domain; Region: Mga; pfam05043 418127006617 PRD domain; Region: PRD; pfam00874 418127006618 PRD domain; Region: PRD; pfam00874 418127006619 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 418127006620 active site 418127006621 P-loop; other site 418127006622 phosphorylation site [posttranslational modification] 418127006623 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 418127006624 active site 418127006625 phosphorylation site [posttranslational modification] 418127006626 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127006627 active site 418127006628 phosphorylation site [posttranslational modification] 418127006629 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 418127006630 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 418127006631 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 418127006632 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 418127006633 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 418127006634 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127006635 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127006636 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127006637 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127006638 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127006639 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127006640 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127006641 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 418127006642 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 418127006643 active site 418127006644 substrate binding site [chemical binding]; other site 418127006645 metal binding site [ion binding]; metal-binding site 418127006646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 418127006647 YbbR-like protein; Region: YbbR; pfam07949 418127006648 TIGR00159 family protein; Region: TIGR00159 418127006649 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 418127006650 Arginase family; Region: Arginase; cd09989 418127006651 active site 418127006652 Mn binding site [ion binding]; other site 418127006653 oligomer interface [polypeptide binding]; other site 418127006654 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 418127006655 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 418127006656 Walker A motif; other site 418127006657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006658 Major Facilitator Superfamily; Region: MFS_1; pfam07690 418127006659 putative substrate translocation pore; other site 418127006660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006661 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 418127006662 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 418127006663 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 418127006664 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 418127006665 substrate binding site; other site 418127006666 dimerization interface; other site 418127006667 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 418127006668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 418127006669 Nucleoside recognition; Region: Gate; pfam07670 418127006670 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 418127006671 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 418127006672 ABC-ATPase subunit interface; other site 418127006673 dimer interface [polypeptide binding]; other site 418127006674 putative PBP binding regions; other site 418127006675 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 418127006676 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 418127006677 ABC-ATPase subunit interface; other site 418127006678 dimer interface [polypeptide binding]; other site 418127006679 putative PBP binding regions; other site 418127006680 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 418127006681 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 418127006682 siderophore binding site; other site 418127006683 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 418127006684 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 418127006685 dimer interface [polypeptide binding]; other site 418127006686 active site 418127006687 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 418127006688 substrate binding site [chemical binding]; other site 418127006689 catalytic residue [active] 418127006690 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 418127006691 IucA / IucC family; Region: IucA_IucC; pfam04183 418127006692 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 418127006693 H+ Antiporter protein; Region: 2A0121; TIGR00900 418127006694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006695 putative substrate translocation pore; other site 418127006696 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 418127006697 IucA / IucC family; Region: IucA_IucC; pfam04183 418127006698 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 418127006699 Asp23 family; Region: Asp23; pfam03780 418127006700 Small integral membrane protein [Function unknown]; Region: COG5547 418127006701 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 418127006702 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 418127006703 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 418127006704 putative NAD(P) binding site [chemical binding]; other site 418127006705 dimer interface [polypeptide binding]; other site 418127006706 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 418127006707 Prostaglandin dehydrogenases; Region: PGDH; cd05288 418127006708 NAD(P) binding site [chemical binding]; other site 418127006709 substrate binding site [chemical binding]; other site 418127006710 dimer interface [polypeptide binding]; other site 418127006711 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 418127006712 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 418127006713 beta-galactosidase; Region: BGL; TIGR03356 418127006714 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 418127006715 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 418127006716 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 418127006717 active site 418127006718 P-loop; other site 418127006719 phosphorylation site [posttranslational modification] 418127006720 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 418127006721 methionine cluster; other site 418127006722 active site 418127006723 phosphorylation site [posttranslational modification] 418127006724 metal binding site [ion binding]; metal-binding site 418127006725 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 418127006726 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 418127006727 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 418127006728 putative substrate binding site [chemical binding]; other site 418127006729 putative ATP binding site [chemical binding]; other site 418127006730 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 418127006731 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 418127006732 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 418127006733 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 418127006734 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 418127006735 NAD-dependent deacetylase; Provisional; Region: PRK00481 418127006736 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 418127006737 NAD+ binding site [chemical binding]; other site 418127006738 substrate binding site [chemical binding]; other site 418127006739 putative Zn binding site [ion binding]; other site 418127006740 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 418127006741 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 418127006742 active site 418127006743 catalytic tetrad [active] 418127006744 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 418127006745 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 418127006746 DNA binding residues [nucleotide binding] 418127006747 putative dimer interface [polypeptide binding]; other site 418127006748 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 418127006749 substrate binding site [chemical binding]; other site 418127006750 catalytic residues [active] 418127006751 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 418127006752 Peptidase family M23; Region: Peptidase_M23; pfam01551 418127006753 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 418127006754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 418127006755 active site 418127006756 motif I; other site 418127006757 motif II; other site 418127006758 MAP domain; Region: MAP; pfam03642 418127006759 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 418127006760 acetolactate synthase; Reviewed; Region: PRK08617 418127006761 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 418127006762 PYR/PP interface [polypeptide binding]; other site 418127006763 dimer interface [polypeptide binding]; other site 418127006764 TPP binding site [chemical binding]; other site 418127006765 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 418127006766 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 418127006767 TPP-binding site [chemical binding]; other site 418127006768 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 418127006769 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 418127006770 putative active site [active] 418127006771 putative NTP binding site [chemical binding]; other site 418127006772 putative nucleic acid binding site [nucleotide binding]; other site 418127006773 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 418127006774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 418127006775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 418127006776 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 418127006777 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 418127006778 23S rRNA interface [nucleotide binding]; other site 418127006779 L3 interface [polypeptide binding]; other site 418127006780 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 418127006781 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 418127006782 dimerization interface 3.5A [polypeptide binding]; other site 418127006783 active site 418127006784 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 418127006785 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 418127006786 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 418127006787 Walker A/P-loop; other site 418127006788 ATP binding site [chemical binding]; other site 418127006789 Q-loop/lid; other site 418127006790 ABC transporter signature motif; other site 418127006791 Walker B; other site 418127006792 D-loop; other site 418127006793 H-loop/switch region; other site 418127006794 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 418127006795 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 418127006796 Walker A/P-loop; other site 418127006797 ATP binding site [chemical binding]; other site 418127006798 Q-loop/lid; other site 418127006799 ABC transporter signature motif; other site 418127006800 Walker B; other site 418127006801 D-loop; other site 418127006802 H-loop/switch region; other site 418127006803 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 418127006804 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 418127006805 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 418127006806 alphaNTD homodimer interface [polypeptide binding]; other site 418127006807 alphaNTD - beta interaction site [polypeptide binding]; other site 418127006808 alphaNTD - beta' interaction site [polypeptide binding]; other site 418127006809 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 418127006810 30S ribosomal protein S11; Validated; Region: PRK05309 418127006811 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 418127006812 30S ribosomal protein S13; Region: bact_S13; TIGR03631 418127006813 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 418127006814 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 418127006815 rRNA binding site [nucleotide binding]; other site 418127006816 predicted 30S ribosome binding site; other site 418127006817 adenylate kinase; Reviewed; Region: adk; PRK00279 418127006818 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 418127006819 AMP-binding site [chemical binding]; other site 418127006820 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 418127006821 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 418127006822 SecY translocase; Region: SecY; pfam00344 418127006823 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 418127006824 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 418127006825 23S rRNA binding site [nucleotide binding]; other site 418127006826 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 418127006827 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 418127006828 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 418127006829 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 418127006830 5S rRNA interface [nucleotide binding]; other site 418127006831 L27 interface [polypeptide binding]; other site 418127006832 23S rRNA interface [nucleotide binding]; other site 418127006833 L5 interface [polypeptide binding]; other site 418127006834 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 418127006835 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 418127006836 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 418127006837 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 418127006838 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 418127006839 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 418127006840 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 418127006841 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 418127006842 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 418127006843 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 418127006844 RNA binding site [nucleotide binding]; other site 418127006845 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 418127006846 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 418127006847 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 418127006848 23S rRNA interface [nucleotide binding]; other site 418127006849 putative translocon interaction site; other site 418127006850 signal recognition particle (SRP54) interaction site; other site 418127006851 L23 interface [polypeptide binding]; other site 418127006852 trigger factor interaction site; other site 418127006853 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 418127006854 23S rRNA interface [nucleotide binding]; other site 418127006855 5S rRNA interface [nucleotide binding]; other site 418127006856 putative antibiotic binding site [chemical binding]; other site 418127006857 L25 interface [polypeptide binding]; other site 418127006858 L27 interface [polypeptide binding]; other site 418127006859 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 418127006860 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 418127006861 G-X-X-G motif; other site 418127006862 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 418127006863 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 418127006864 putative translocon binding site; other site 418127006865 protein-rRNA interface [nucleotide binding]; other site 418127006866 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 418127006867 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 418127006868 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 418127006869 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 418127006870 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 418127006871 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 418127006872 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 418127006873 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 418127006874 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 418127006875 DNA topoisomerase III; Provisional; Region: PRK07726 418127006876 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 418127006877 active site 418127006878 putative interdomain interaction site [polypeptide binding]; other site 418127006879 putative metal-binding site [ion binding]; other site 418127006880 putative nucleotide binding site [chemical binding]; other site 418127006881 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 418127006882 domain I; other site 418127006883 DNA binding groove [nucleotide binding] 418127006884 phosphate binding site [ion binding]; other site 418127006885 domain II; other site 418127006886 domain III; other site 418127006887 nucleotide binding site [chemical binding]; other site 418127006888 catalytic site [active] 418127006889 domain IV; other site 418127006890 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 418127006891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127006892 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 418127006893 Coenzyme A binding pocket [chemical binding]; other site 418127006894 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 418127006895 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 418127006896 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 418127006897 Predicted permeases [General function prediction only]; Region: COG0679 418127006898 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 418127006899 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 418127006900 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 418127006901 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 418127006902 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 418127006903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006904 Major Facilitator Superfamily; Region: MFS_1; pfam07690 418127006905 putative substrate translocation pore; other site 418127006906 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 418127006907 Transcriptional regulators [Transcription]; Region: MarR; COG1846 418127006908 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 418127006909 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 418127006910 FeS/SAM binding site; other site 418127006911 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 418127006912 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 418127006913 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 418127006914 GTP binding site; other site 418127006915 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 418127006916 MoaE interaction surface [polypeptide binding]; other site 418127006917 MoeB interaction surface [polypeptide binding]; other site 418127006918 thiocarboxylated glycine; other site 418127006919 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 418127006920 MoaE homodimer interface [polypeptide binding]; other site 418127006921 MoaD interaction [polypeptide binding]; other site 418127006922 active site residues [active] 418127006923 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 418127006924 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 418127006925 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 418127006926 dimer interface [polypeptide binding]; other site 418127006927 putative functional site; other site 418127006928 putative MPT binding site; other site 418127006929 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 418127006930 trimer interface [polypeptide binding]; other site 418127006931 dimer interface [polypeptide binding]; other site 418127006932 putative active site [active] 418127006933 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 418127006934 MPT binding site; other site 418127006935 trimer interface [polypeptide binding]; other site 418127006936 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 418127006937 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 418127006938 ATP binding site [chemical binding]; other site 418127006939 substrate interface [chemical binding]; other site 418127006940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 418127006941 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 418127006942 Walker A/P-loop; other site 418127006943 ATP binding site [chemical binding]; other site 418127006944 Q-loop/lid; other site 418127006945 ABC transporter signature motif; other site 418127006946 Walker B; other site 418127006947 D-loop; other site 418127006948 H-loop/switch region; other site 418127006949 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 418127006950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127006951 dimer interface [polypeptide binding]; other site 418127006952 conserved gate region; other site 418127006953 putative PBP binding loops; other site 418127006954 ABC-ATPase subunit interface; other site 418127006955 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 418127006956 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 418127006957 substrate binding pocket [chemical binding]; other site 418127006958 membrane-bound complex binding site; other site 418127006959 hinge residues; other site 418127006960 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 418127006961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127006962 Coenzyme A binding pocket [chemical binding]; other site 418127006963 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 418127006964 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 418127006965 active site 418127006966 dimerization interface [polypeptide binding]; other site 418127006967 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 418127006968 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 418127006969 intersubunit interface [polypeptide binding]; other site 418127006970 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 418127006971 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 418127006972 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 418127006973 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 418127006974 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 418127006975 alpha-gamma subunit interface [polypeptide binding]; other site 418127006976 beta-gamma subunit interface [polypeptide binding]; other site 418127006977 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 418127006978 gamma-beta subunit interface [polypeptide binding]; other site 418127006979 alpha-beta subunit interface [polypeptide binding]; other site 418127006980 urease subunit alpha; Reviewed; Region: ureC; PRK13207 418127006981 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 418127006982 subunit interactions [polypeptide binding]; other site 418127006983 active site 418127006984 flap region; other site 418127006985 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 418127006986 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 418127006987 dimer interface [polypeptide binding]; other site 418127006988 catalytic residues [active] 418127006989 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 418127006990 UreF; Region: UreF; pfam01730 418127006991 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 418127006992 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 418127006993 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 418127006994 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 418127006995 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 418127006996 Transcriptional regulators [Transcription]; Region: MarR; COG1846 418127006997 Helix-turn-helix domain; Region: HTH_18; pfam12833 418127006998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 418127006999 Surface antigen [General function prediction only]; Region: COG3942 418127007000 CHAP domain; Region: CHAP; pfam05257 418127007001 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 418127007002 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 418127007003 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 418127007004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 418127007005 Surface antigen [General function prediction only]; Region: COG3942 418127007006 CHAP domain; Region: CHAP; pfam05257 418127007007 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 418127007008 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 418127007009 putative ligand binding site [chemical binding]; other site 418127007010 putative NAD binding site [chemical binding]; other site 418127007011 catalytic site [active] 418127007012 hypothetical protein; Provisional; Region: PRK06753 418127007013 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 418127007014 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 418127007015 Lysozyme subfamily 2; Region: LYZ2; smart00047 418127007016 Uncharacterized conserved protein [Function unknown]; Region: COG2427 418127007017 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 418127007018 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 418127007019 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 418127007020 4Fe-4S binding domain; Region: Fer4; pfam00037 418127007021 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 418127007022 [4Fe-4S] binding site [ion binding]; other site 418127007023 molybdopterin cofactor binding site; other site 418127007024 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 418127007025 molybdopterin cofactor binding site; other site 418127007026 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 418127007027 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 418127007028 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 418127007029 active site 418127007030 Predicted transcriptional regulator [Transcription]; Region: COG2378 418127007031 HTH domain; Region: HTH_11; pfam08279 418127007032 CAAX protease self-immunity; Region: Abi; pfam02517 418127007033 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 418127007034 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 418127007035 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 418127007036 putative active site [active] 418127007037 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 418127007038 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 418127007039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127007040 active site 418127007041 motif I; other site 418127007042 motif II; other site 418127007043 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 418127007044 Sodium Bile acid symporter family; Region: SBF; pfam01758 418127007045 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 418127007046 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 418127007047 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 418127007048 active site turn [active] 418127007049 phosphorylation site [posttranslational modification] 418127007050 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 418127007051 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 418127007052 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 418127007053 putative active site [active] 418127007054 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 418127007055 putative hydrophobic ligand binding site [chemical binding]; other site 418127007056 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 418127007057 oxidoreductase; Provisional; Region: PRK07985 418127007058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127007059 NAD(P) binding site [chemical binding]; other site 418127007060 active site 418127007061 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 418127007062 amidohydrolase; Region: amidohydrolases; TIGR01891 418127007063 metal binding site [ion binding]; metal-binding site 418127007064 dimer interface [polypeptide binding]; other site 418127007065 imidazolonepropionase; Validated; Region: PRK09356 418127007066 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 418127007067 active site 418127007068 urocanate hydratase; Provisional; Region: PRK05414 418127007069 Transcriptional regulator [Transcription]; Region: LysR; COG0583 418127007070 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 418127007071 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 418127007072 dimerization interface [polypeptide binding]; other site 418127007073 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 418127007074 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 418127007075 putative active site [active] 418127007076 putative Mg binding site [ion binding]; other site 418127007077 formimidoylglutamase; Provisional; Region: PRK13775 418127007078 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 418127007079 putative active site [active] 418127007080 putative metal binding site [ion binding]; other site 418127007081 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 418127007082 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 418127007083 tetramer (dimer of dimers) interface [polypeptide binding]; other site 418127007084 active site 418127007085 dimer interface [polypeptide binding]; other site 418127007086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 418127007087 MOSC domain; Region: MOSC; pfam03473 418127007088 3-alpha domain; Region: 3-alpha; pfam03475 418127007089 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 418127007090 active site 418127007091 catalytic residues [active] 418127007092 Uncharacterized conserved protein [Function unknown]; Region: COG1742 418127007093 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 418127007094 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 418127007095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 418127007096 Walker A/P-loop; other site 418127007097 ATP binding site [chemical binding]; other site 418127007098 Q-loop/lid; other site 418127007099 ABC transporter signature motif; other site 418127007100 Walker B; other site 418127007101 D-loop; other site 418127007102 H-loop/switch region; other site 418127007103 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 418127007104 Predicted membrane protein [Function unknown]; Region: COG3152 418127007105 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 418127007106 active site 418127007107 DNA binding site [nucleotide binding] 418127007108 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 418127007109 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 418127007110 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 418127007111 homotetramer interface [polypeptide binding]; other site 418127007112 FMN binding site [chemical binding]; other site 418127007113 homodimer contacts [polypeptide binding]; other site 418127007114 putative active site [active] 418127007115 putative substrate binding site [chemical binding]; other site 418127007116 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 418127007117 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 418127007118 oligomer interface [polypeptide binding]; other site 418127007119 metal binding site [ion binding]; metal-binding site 418127007120 metal binding site [ion binding]; metal-binding site 418127007121 putative Cl binding site [ion binding]; other site 418127007122 aspartate ring; other site 418127007123 basic sphincter; other site 418127007124 hydrophobic gate; other site 418127007125 periplasmic entrance; other site 418127007126 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 418127007127 active site 418127007128 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 418127007129 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 418127007130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127007131 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 418127007132 putative substrate translocation pore; other site 418127007133 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 418127007134 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 418127007135 HlyD family secretion protein; Region: HlyD_3; pfam13437 418127007136 lipoyl-biotinyl attachment site [posttranslational modification]; other site 418127007137 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 418127007138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127007139 putative substrate translocation pore; other site 418127007140 Predicted membrane protein [Function unknown]; Region: COG4640 418127007141 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 418127007142 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 418127007143 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 418127007144 putative Zn2+ binding site [ion binding]; other site 418127007145 putative DNA binding site [nucleotide binding]; other site 418127007146 Uncharacterized conserved protein [Function unknown]; Region: COG1434 418127007147 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 418127007148 putative active site [active] 418127007149 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 418127007150 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 418127007151 Walker A/P-loop; other site 418127007152 ATP binding site [chemical binding]; other site 418127007153 Q-loop/lid; other site 418127007154 ABC transporter signature motif; other site 418127007155 Walker B; other site 418127007156 D-loop; other site 418127007157 H-loop/switch region; other site 418127007158 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 418127007159 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 418127007160 FtsX-like permease family; Region: FtsX; pfam02687 418127007161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127007162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127007163 active site 418127007164 phosphorylation site [posttranslational modification] 418127007165 intermolecular recognition site; other site 418127007166 dimerization interface [polypeptide binding]; other site 418127007167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 418127007168 DNA binding site [nucleotide binding] 418127007169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 418127007170 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 418127007171 dimerization interface [polypeptide binding]; other site 418127007172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 418127007173 dimer interface [polypeptide binding]; other site 418127007174 phosphorylation site [posttranslational modification] 418127007175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127007176 ATP binding site [chemical binding]; other site 418127007177 Mg2+ binding site [ion binding]; other site 418127007178 G-X-G motif; other site 418127007179 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 418127007180 LytTr DNA-binding domain; Region: LytTR; smart00850 418127007181 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 418127007182 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 418127007183 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 418127007184 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 418127007185 L-lactate permease; Region: Lactate_perm; cl00701 418127007186 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 418127007187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127007188 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 418127007189 Coenzyme A binding pocket [chemical binding]; other site 418127007190 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 418127007191 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 418127007192 NAD(P) binding site [chemical binding]; other site 418127007193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127007194 Coenzyme A binding pocket [chemical binding]; other site 418127007195 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 418127007196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 418127007197 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 418127007198 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 418127007199 Predicted membrane protein [Function unknown]; Region: COG1511 418127007200 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 418127007201 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 418127007202 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 418127007203 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 418127007204 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 418127007205 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 418127007206 Cl binding site [ion binding]; other site 418127007207 oligomer interface [polypeptide binding]; other site 418127007208 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 418127007209 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 418127007210 active site turn [active] 418127007211 phosphorylation site [posttranslational modification] 418127007212 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 418127007213 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 418127007214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127007215 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127007216 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 418127007217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 418127007218 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 418127007219 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 418127007220 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 418127007221 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 418127007222 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 418127007223 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 418127007224 MarR family; Region: MarR_2; pfam12802 418127007225 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 418127007226 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 418127007227 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 418127007228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127007229 putative substrate translocation pore; other site 418127007230 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 418127007231 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 418127007232 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 418127007233 DNA binding residues [nucleotide binding] 418127007234 dimer interface [polypeptide binding]; other site 418127007235 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 418127007236 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 418127007237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127007238 active site 418127007239 phosphorylation site [posttranslational modification] 418127007240 intermolecular recognition site; other site 418127007241 dimerization interface [polypeptide binding]; other site 418127007242 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 418127007243 DNA binding residues [nucleotide binding] 418127007244 dimerization interface [polypeptide binding]; other site 418127007245 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 418127007246 Histidine kinase; Region: HisKA_3; pfam07730 418127007247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127007248 ATP binding site [chemical binding]; other site 418127007249 Mg2+ binding site [ion binding]; other site 418127007250 G-X-G motif; other site 418127007251 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 418127007252 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 418127007253 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 418127007254 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 418127007255 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 418127007256 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 418127007257 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 418127007258 [4Fe-4S] binding site [ion binding]; other site 418127007259 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 418127007260 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 418127007261 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 418127007262 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 418127007263 molybdopterin cofactor binding site; other site 418127007264 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 418127007265 active site 418127007266 SAM binding site [chemical binding]; other site 418127007267 homodimer interface [polypeptide binding]; other site 418127007268 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 418127007269 [2Fe-2S] cluster binding site [ion binding]; other site 418127007270 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 418127007271 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 418127007272 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 418127007273 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 418127007274 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 418127007275 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 418127007276 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 418127007277 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 418127007278 putative active site [active] 418127007279 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 418127007280 active site 418127007281 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 418127007282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127007283 Coenzyme A binding pocket [chemical binding]; other site 418127007284 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 418127007285 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 418127007286 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 418127007287 putative hydrophobic ligand binding site [chemical binding]; other site 418127007288 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 418127007289 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 418127007290 intersubunit interface [polypeptide binding]; other site 418127007291 YodA lipocalin-like domain; Region: YodA; pfam09223 418127007292 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 418127007293 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 418127007294 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 418127007295 Thioredoxin; Region: Thioredoxin_4; cl17273 418127007296 FemAB family; Region: FemAB; pfam02388 418127007297 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 418127007298 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 418127007299 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 418127007300 Walker A/P-loop; other site 418127007301 ATP binding site [chemical binding]; other site 418127007302 Q-loop/lid; other site 418127007303 ABC transporter signature motif; other site 418127007304 Walker B; other site 418127007305 D-loop; other site 418127007306 H-loop/switch region; other site 418127007307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 418127007308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127007309 putative PBP binding loops; other site 418127007310 dimer interface [polypeptide binding]; other site 418127007311 ABC-ATPase subunit interface; other site 418127007312 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 418127007313 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 418127007314 substrate binding pocket [chemical binding]; other site 418127007315 membrane-bound complex binding site; other site 418127007316 hinge residues; other site 418127007317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127007318 Major Facilitator Superfamily; Region: MFS_1; pfam07690 418127007319 putative substrate translocation pore; other site 418127007320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127007321 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 418127007322 catalytic core [active] 418127007323 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 418127007324 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 418127007325 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 418127007326 B domain; Region: B; pfam02216 418127007327 B domain; Region: B; pfam02216 418127007328 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 418127007329 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 418127007330 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 418127007331 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 418127007332 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 418127007333 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 418127007334 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 418127007335 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127007336 catalytic residue [active] 418127007337 biotin synthase; Validated; Region: PRK06256 418127007338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 418127007339 FeS/SAM binding site; other site 418127007340 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 418127007341 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 418127007342 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 418127007343 inhibitor-cofactor binding pocket; inhibition site 418127007344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127007345 catalytic residue [active] 418127007346 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 418127007347 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 418127007348 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 418127007349 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 418127007350 Walker A/P-loop; other site 418127007351 ATP binding site [chemical binding]; other site 418127007352 Q-loop/lid; other site 418127007353 ABC transporter signature motif; other site 418127007354 Walker B; other site 418127007355 D-loop; other site 418127007356 H-loop/switch region; other site 418127007357 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 418127007358 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 418127007359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 418127007360 Walker A/P-loop; other site 418127007361 ATP binding site [chemical binding]; other site 418127007362 Q-loop/lid; other site 418127007363 ABC transporter signature motif; other site 418127007364 Walker B; other site 418127007365 D-loop; other site 418127007366 H-loop/switch region; other site 418127007367 Predicted membrane protein [Function unknown]; Region: COG2246 418127007368 GtrA-like protein; Region: GtrA; pfam04138 418127007369 glycerate kinase; Region: TIGR00045 418127007370 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 418127007371 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 418127007372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127007373 putative substrate translocation pore; other site 418127007374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 418127007375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 418127007376 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 418127007377 putative phosphoesterase; Region: acc_ester; TIGR03729 418127007378 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 418127007379 Spore germination protein; Region: Spore_permease; cl17796 418127007380 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 418127007381 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 418127007382 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 418127007383 Beta-lactamase; Region: Beta-lactamase; pfam00144 418127007384 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 418127007385 extended (e) SDRs; Region: SDR_e; cd08946 418127007386 NAD(P) binding site [chemical binding]; other site 418127007387 active site 418127007388 substrate binding site [chemical binding]; other site 418127007389 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 418127007390 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 418127007391 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 418127007392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127007393 putative substrate translocation pore; other site 418127007394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127007395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127007396 dimer interface [polypeptide binding]; other site 418127007397 conserved gate region; other site 418127007398 ABC-ATPase subunit interface; other site 418127007399 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 418127007400 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 418127007401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127007402 dimer interface [polypeptide binding]; other site 418127007403 conserved gate region; other site 418127007404 putative PBP binding loops; other site 418127007405 ABC-ATPase subunit interface; other site 418127007406 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 418127007407 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 418127007408 Walker A/P-loop; other site 418127007409 ATP binding site [chemical binding]; other site 418127007410 Q-loop/lid; other site 418127007411 ABC transporter signature motif; other site 418127007412 Walker B; other site 418127007413 D-loop; other site 418127007414 H-loop/switch region; other site 418127007415 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 418127007416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 418127007417 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 418127007418 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 418127007419 amino acid transporter; Region: 2A0306; TIGR00909 418127007420 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 418127007421 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 418127007422 substrate binding pocket [chemical binding]; other site 418127007423 catalytic triad [active] 418127007424 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 418127007425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127007426 putative substrate translocation pore; other site 418127007427 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 418127007428 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 418127007429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 418127007430 Walker A/P-loop; other site 418127007431 ATP binding site [chemical binding]; other site 418127007432 Q-loop/lid; other site 418127007433 ABC transporter signature motif; other site 418127007434 Walker B; other site 418127007435 D-loop; other site 418127007436 H-loop/switch region; other site 418127007437 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 418127007438 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 418127007439 oligomer interface [polypeptide binding]; other site 418127007440 active site 418127007441 metal binding site [ion binding]; metal-binding site 418127007442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 418127007443 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 418127007444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 418127007445 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 418127007446 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 418127007447 active site 418127007448 FMN binding site [chemical binding]; other site 418127007449 substrate binding site [chemical binding]; other site 418127007450 3Fe-4S cluster binding site [ion binding]; other site 418127007451 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 418127007452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127007453 Major Facilitator Superfamily; Region: MFS_1; pfam07690 418127007454 putative substrate translocation pore; other site 418127007455 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 418127007456 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 418127007457 Walker A/P-loop; other site 418127007458 ATP binding site [chemical binding]; other site 418127007459 Q-loop/lid; other site 418127007460 ABC transporter signature motif; other site 418127007461 Walker B; other site 418127007462 D-loop; other site 418127007463 H-loop/switch region; other site 418127007464 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 418127007465 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 418127007466 Walker A/P-loop; other site 418127007467 ATP binding site [chemical binding]; other site 418127007468 Q-loop/lid; other site 418127007469 ABC transporter signature motif; other site 418127007470 Walker B; other site 418127007471 D-loop; other site 418127007472 H-loop/switch region; other site 418127007473 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 418127007474 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 418127007475 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 418127007476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127007477 dimer interface [polypeptide binding]; other site 418127007478 conserved gate region; other site 418127007479 ABC-ATPase subunit interface; other site 418127007480 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 418127007481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 418127007482 dimer interface [polypeptide binding]; other site 418127007483 conserved gate region; other site 418127007484 putative PBP binding loops; other site 418127007485 ABC-ATPase subunit interface; other site 418127007486 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 418127007487 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 418127007488 substrate binding site [chemical binding]; other site 418127007489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 418127007490 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 418127007491 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 418127007492 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 418127007493 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 418127007494 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 418127007495 short chain dehydrogenase; Validated; Region: PRK08589 418127007496 classical (c) SDRs; Region: SDR_c; cd05233 418127007497 NAD(P) binding site [chemical binding]; other site 418127007498 active site 418127007499 AbgT putative transporter family; Region: ABG_transport; pfam03806 418127007500 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 418127007501 Uncharacterized conserved protein [Function unknown]; Region: COG2128 418127007502 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 418127007503 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 418127007504 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 418127007505 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 418127007506 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 418127007507 classical (c) SDRs; Region: SDR_c; cd05233 418127007508 NAD(P) binding site [chemical binding]; other site 418127007509 active site 418127007510 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 418127007511 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127007512 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127007513 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127007514 Protein of unknown function, DUF576; Region: DUF576; pfam04507 418127007515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127007516 nucleotide binding region [chemical binding]; other site 418127007517 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 418127007518 ATP-binding site [chemical binding]; other site 418127007519 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 418127007520 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 418127007521 PLD-like domain; Region: PLDc_2; pfam13091 418127007522 putative homodimer interface [polypeptide binding]; other site 418127007523 putative active site [active] 418127007524 catalytic site [active] 418127007525 DEAD-like helicases superfamily; Region: DEXDc; smart00487 418127007526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127007527 ATP binding site [chemical binding]; other site 418127007528 putative Mg++ binding site [ion binding]; other site 418127007529 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 418127007530 active site 418127007531 8-oxo-dGMP binding site [chemical binding]; other site 418127007532 nudix motif; other site 418127007533 metal binding site [ion binding]; metal-binding site 418127007534 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 418127007535 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 418127007536 active site 418127007537 substrate binding site [chemical binding]; other site 418127007538 metal binding site [ion binding]; metal-binding site 418127007539 H+ Antiporter protein; Region: 2A0121; TIGR00900 418127007540 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 418127007541 legume lectins; Region: lectin_L-type; cl14058 418127007542 homotetramer interaction site [polypeptide binding]; other site 418127007543 carbohydrate binding site [chemical binding]; other site 418127007544 metal binding site [ion binding]; metal-binding site 418127007545 G5 domain; Region: G5; pfam07501 418127007546 G5 domain; Region: G5; pfam07501 418127007547 G5 domain; Region: G5; pfam07501 418127007548 G5 domain; Region: G5; pfam07501 418127007549 G5 domain; Region: G5; pfam07501 418127007550 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 418127007551 G5 domain; Region: G5; pfam07501 418127007552 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 418127007553 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 418127007554 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 418127007555 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 418127007556 Transcriptional regulators [Transcription]; Region: MarR; COG1846 418127007557 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 418127007558 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 418127007559 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 418127007560 active site 418127007561 tetramer interface; other site 418127007562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127007563 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127007564 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 418127007565 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 418127007566 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 418127007567 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 418127007568 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 418127007569 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 418127007570 GntP family permease; Region: GntP_permease; pfam02447 418127007571 fructuronate transporter; Provisional; Region: PRK10034; cl15264 418127007572 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 418127007573 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 418127007574 N- and C-terminal domain interface [polypeptide binding]; other site 418127007575 active site 418127007576 catalytic site [active] 418127007577 metal binding site [ion binding]; metal-binding site 418127007578 carbohydrate binding site [chemical binding]; other site 418127007579 ATP binding site [chemical binding]; other site 418127007580 Transcriptional regulators [Transcription]; Region: GntR; COG1802 418127007581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 418127007582 DNA-binding site [nucleotide binding]; DNA binding site 418127007583 FCD domain; Region: FCD; pfam07729 418127007584 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 418127007585 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 418127007586 DNA binding residues [nucleotide binding] 418127007587 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 418127007588 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 418127007589 synthetase active site [active] 418127007590 NTP binding site [chemical binding]; other site 418127007591 metal binding site [ion binding]; metal-binding site 418127007592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 418127007593 Predicted membrane protein [Function unknown]; Region: COG1289 418127007594 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 418127007595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127007596 D-galactonate transporter; Region: 2A0114; TIGR00893 418127007597 putative substrate translocation pore; other site 418127007598 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 418127007599 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 418127007600 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 418127007601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 418127007602 Walker A/P-loop; other site 418127007603 ATP binding site [chemical binding]; other site 418127007604 Q-loop/lid; other site 418127007605 ABC transporter signature motif; other site 418127007606 Walker B; other site 418127007607 D-loop; other site 418127007608 H-loop/switch region; other site 418127007609 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 418127007610 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 418127007611 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 418127007612 Uncharacterized membrane protein [Function unknown]; Region: COG3949 418127007613 Predicted esterase [General function prediction only]; Region: COG0400 418127007614 putative hydrolase; Provisional; Region: PRK11460 418127007615 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 418127007616 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 418127007617 Zn binding site [ion binding]; other site 418127007618 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 418127007619 Zn binding site [ion binding]; other site 418127007620 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 418127007621 MarR family; Region: MarR; pfam01047 418127007622 Predicted acetyltransferase [General function prediction only]; Region: COG2388 418127007623 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 418127007624 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 418127007625 putative metal binding site [ion binding]; other site 418127007626 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 418127007627 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 418127007628 dimer interface [polypeptide binding]; other site 418127007629 FMN binding site [chemical binding]; other site 418127007630 D-lactate dehydrogenase; Provisional; Region: PRK12480 418127007631 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 418127007632 homodimer interface [polypeptide binding]; other site 418127007633 ligand binding site [chemical binding]; other site 418127007634 NAD binding site [chemical binding]; other site 418127007635 catalytic site [active] 418127007636 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 418127007637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 418127007638 active site 418127007639 motif I; other site 418127007640 motif II; other site 418127007641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 418127007642 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 418127007643 Walker A/P-loop; other site 418127007644 ATP binding site [chemical binding]; other site 418127007645 Q-loop/lid; other site 418127007646 ABC transporter signature motif; other site 418127007647 Walker B; other site 418127007648 D-loop; other site 418127007649 H-loop/switch region; other site 418127007650 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 418127007651 active site 418127007652 catalytic site [active] 418127007653 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 418127007654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127007655 Coenzyme A binding pocket [chemical binding]; other site 418127007656 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 418127007657 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 418127007658 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 418127007659 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 418127007660 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 418127007661 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 418127007662 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 418127007663 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 418127007664 EamA-like transporter family; Region: EamA; pfam00892 418127007665 EamA-like transporter family; Region: EamA; pfam00892 418127007666 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 418127007667 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 418127007668 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 418127007669 catalytic residues [active] 418127007670 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 418127007671 active site 418127007672 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 418127007673 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 418127007674 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 418127007675 active site turn [active] 418127007676 phosphorylation site [posttranslational modification] 418127007677 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 418127007678 HPr interaction site; other site 418127007679 glycerol kinase (GK) interaction site [polypeptide binding]; other site 418127007680 active site 418127007681 phosphorylation site [posttranslational modification] 418127007682 pyruvate oxidase; Provisional; Region: PRK08611 418127007683 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 418127007684 PYR/PP interface [polypeptide binding]; other site 418127007685 tetramer interface [polypeptide binding]; other site 418127007686 dimer interface [polypeptide binding]; other site 418127007687 TPP binding site [chemical binding]; other site 418127007688 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 418127007689 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 418127007690 TPP-binding site [chemical binding]; other site 418127007691 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 418127007692 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 418127007693 Transcriptional regulator [Transcription]; Region: LysR; COG0583 418127007694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 418127007695 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 418127007696 putative dimerization interface [polypeptide binding]; other site 418127007697 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 418127007698 Surface antigen [General function prediction only]; Region: COG3942 418127007699 CHAP domain; Region: CHAP; pfam05257 418127007700 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 418127007701 homodimer interface [polypeptide binding]; other site 418127007702 catalytic residues [active] 418127007703 NAD binding site [chemical binding]; other site 418127007704 substrate binding pocket [chemical binding]; other site 418127007705 flexible flap; other site 418127007706 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 418127007707 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 418127007708 dimer interface [polypeptide binding]; other site 418127007709 active site 418127007710 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 418127007711 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 418127007712 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 418127007713 DNA binding site [nucleotide binding] 418127007714 active site 418127007715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127007716 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 418127007717 Walker A motif; other site 418127007718 ATP binding site [chemical binding]; other site 418127007719 Walker B motif; other site 418127007720 arginine finger; other site 418127007721 UvrB/uvrC motif; Region: UVR; pfam02151 418127007722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 418127007723 Walker A motif; other site 418127007724 ATP binding site [chemical binding]; other site 418127007725 Walker B motif; other site 418127007726 arginine finger; other site 418127007727 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 418127007728 Virus attachment protein p12 family; Region: P12; pfam12669 418127007729 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 418127007730 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 418127007731 G1 box; other site 418127007732 GTP/Mg2+ binding site [chemical binding]; other site 418127007733 Switch I region; other site 418127007734 G2 box; other site 418127007735 G3 box; other site 418127007736 Switch II region; other site 418127007737 G4 box; other site 418127007738 G5 box; other site 418127007739 Nucleoside recognition; Region: Gate; pfam07670 418127007740 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 418127007741 Nucleoside recognition; Region: Gate; pfam07670 418127007742 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 418127007743 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 418127007744 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 418127007745 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 418127007746 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 418127007747 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 418127007748 Glutamate binding site [chemical binding]; other site 418127007749 homodimer interface [polypeptide binding]; other site 418127007750 NAD binding site [chemical binding]; other site 418127007751 catalytic residues [active] 418127007752 maltose O-acetyltransferase; Provisional; Region: PRK10092 418127007753 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 418127007754 active site 418127007755 substrate binding site [chemical binding]; other site 418127007756 trimer interface [polypeptide binding]; other site 418127007757 CoA binding site [chemical binding]; other site 418127007758 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 418127007759 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 418127007760 metal-binding site [ion binding] 418127007761 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 418127007762 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 418127007763 metal-binding site [ion binding] 418127007764 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 418127007765 Soluble P-type ATPase [General function prediction only]; Region: COG4087 418127007766 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 418127007767 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 418127007768 metal-binding site [ion binding] 418127007769 D-lactate dehydrogenase; Validated; Region: PRK08605 418127007770 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 418127007771 homodimer interface [polypeptide binding]; other site 418127007772 ligand binding site [chemical binding]; other site 418127007773 NAD binding site [chemical binding]; other site 418127007774 catalytic site [active] 418127007775 transaminase; Reviewed; Region: PRK08068 418127007776 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 418127007777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127007778 homodimer interface [polypeptide binding]; other site 418127007779 catalytic residue [active] 418127007780 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 418127007781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 418127007782 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 418127007783 active site lid residues [active] 418127007784 substrate binding pocket [chemical binding]; other site 418127007785 catalytic residues [active] 418127007786 substrate-Mg2+ binding site; other site 418127007787 aspartate-rich region 1; other site 418127007788 aspartate-rich region 2; other site 418127007789 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 418127007790 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 418127007791 active site 418127007792 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 418127007793 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 418127007794 Surface antigen [General function prediction only]; Region: COG3942 418127007795 CHAP domain; Region: CHAP; pfam05257 418127007796 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 418127007797 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 418127007798 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 418127007799 catalytic triad [active] 418127007800 catalytic triad [active] 418127007801 oxyanion hole [active] 418127007802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127007803 Coenzyme A binding pocket [chemical binding]; other site 418127007804 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 418127007805 N-acetyl-D-glucosamine binding site [chemical binding]; other site 418127007806 catalytic residue [active] 418127007807 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 418127007808 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 418127007809 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 418127007810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 418127007811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 418127007812 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 418127007813 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 418127007814 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 418127007815 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 418127007816 NmrA-like family; Region: NmrA; pfam05368 418127007817 NADP binding site [chemical binding]; other site 418127007818 active site 418127007819 regulatory binding site [polypeptide binding]; other site 418127007820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 418127007821 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 418127007822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 418127007823 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 418127007824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127007825 NAD(P) binding site [chemical binding]; other site 418127007826 active site 418127007827 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 418127007828 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 418127007829 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 418127007830 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 418127007831 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 418127007832 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 418127007833 Nucleoside recognition; Region: Gate; pfam07670 418127007834 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 418127007835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 418127007836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 418127007837 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 418127007838 Phosphotransferase enzyme family; Region: APH; pfam01636 418127007839 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 418127007840 active site 418127007841 ATP binding site [chemical binding]; other site 418127007842 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 418127007843 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 418127007844 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 418127007845 quinone interaction residues [chemical binding]; other site 418127007846 active site 418127007847 catalytic residues [active] 418127007848 FMN binding site [chemical binding]; other site 418127007849 substrate binding site [chemical binding]; other site 418127007850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 418127007851 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 418127007852 dimer interface [polypeptide binding]; other site 418127007853 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 418127007854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 418127007855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 418127007856 Predicted acyl esterases [General function prediction only]; Region: COG2936 418127007857 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 418127007858 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 418127007859 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 418127007860 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 418127007861 tetramerization interface [polypeptide binding]; other site 418127007862 active site 418127007863 pantoate--beta-alanine ligase; Region: panC; TIGR00018 418127007864 Pantoate-beta-alanine ligase; Region: PanC; cd00560 418127007865 active site 418127007866 ATP-binding site [chemical binding]; other site 418127007867 pantoate-binding site; other site 418127007868 HXXH motif; other site 418127007869 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 418127007870 active site 418127007871 oligomerization interface [polypeptide binding]; other site 418127007872 metal binding site [ion binding]; metal-binding site 418127007873 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 418127007874 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 418127007875 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 418127007876 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 418127007877 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 418127007878 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 418127007879 tetramer (dimer of dimers) interface [polypeptide binding]; other site 418127007880 NAD binding site [chemical binding]; other site 418127007881 dimer interface [polypeptide binding]; other site 418127007882 substrate binding site [chemical binding]; other site 418127007883 amino acid transporter; Region: 2A0306; TIGR00909 418127007884 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 418127007885 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 418127007886 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 418127007887 inhibitor-cofactor binding pocket; inhibition site 418127007888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127007889 catalytic residue [active] 418127007890 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 418127007891 catalytic residue [active] 418127007892 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 418127007893 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 418127007894 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 418127007895 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 418127007896 acyl-activating enzyme (AAE) consensus motif; other site 418127007897 AMP binding site [chemical binding]; other site 418127007898 active site 418127007899 CoA binding site [chemical binding]; other site 418127007900 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 418127007901 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 418127007902 choline dehydrogenase; Validated; Region: PRK02106 418127007903 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 418127007904 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 418127007905 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 418127007906 tetramerization interface [polypeptide binding]; other site 418127007907 NAD(P) binding site [chemical binding]; other site 418127007908 catalytic residues [active] 418127007909 Predicted transcriptional regulators [Transcription]; Region: COG1510 418127007910 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 418127007911 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 418127007912 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 418127007913 FeS/SAM binding site; other site 418127007914 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 418127007915 Class III ribonucleotide reductase; Region: RNR_III; cd01675 418127007916 effector binding site; other site 418127007917 active site 418127007918 Zn binding site [ion binding]; other site 418127007919 glycine loop; other site 418127007920 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 418127007921 Citrate transporter; Region: CitMHS; pfam03600 418127007922 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 418127007923 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 418127007924 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 418127007925 Flavodoxin; Region: Flavodoxin_1; pfam00258 418127007926 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 418127007927 FAD binding pocket [chemical binding]; other site 418127007928 FAD binding motif [chemical binding]; other site 418127007929 catalytic residues [active] 418127007930 NAD binding pocket [chemical binding]; other site 418127007931 phosphate binding motif [ion binding]; other site 418127007932 beta-alpha-beta structure motif; other site 418127007933 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 418127007934 catalytic residues [active] 418127007935 dimer interface [polypeptide binding]; other site 418127007936 FtsX-like permease family; Region: FtsX; pfam02687 418127007937 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 418127007938 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 418127007939 Walker A/P-loop; other site 418127007940 ATP binding site [chemical binding]; other site 418127007941 Q-loop/lid; other site 418127007942 ABC transporter signature motif; other site 418127007943 Walker B; other site 418127007944 D-loop; other site 418127007945 H-loop/switch region; other site 418127007946 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 418127007947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127007948 ATP binding site [chemical binding]; other site 418127007949 Mg2+ binding site [ion binding]; other site 418127007950 G-X-G motif; other site 418127007951 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127007952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 418127007953 active site 418127007954 phosphorylation site [posttranslational modification] 418127007955 intermolecular recognition site; other site 418127007956 dimerization interface [polypeptide binding]; other site 418127007957 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 418127007958 DNA binding site [nucleotide binding] 418127007959 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 418127007960 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 418127007961 dimer interface [polypeptide binding]; other site 418127007962 active site 418127007963 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 418127007964 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 418127007965 MarR family; Region: MarR_2; pfam12802 418127007966 Predicted esterase [General function prediction only]; Region: COG0627 418127007967 S-formylglutathione hydrolase; Region: PLN02442 418127007968 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 418127007969 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 418127007970 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 418127007971 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 418127007972 ligand binding site [chemical binding]; other site 418127007973 flexible hinge region; other site 418127007974 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 418127007975 carbamate kinase; Reviewed; Region: PRK12686 418127007976 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 418127007977 putative substrate binding site [chemical binding]; other site 418127007978 nucleotide binding site [chemical binding]; other site 418127007979 nucleotide binding site [chemical binding]; other site 418127007980 homodimer interface [polypeptide binding]; other site 418127007981 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 418127007982 ornithine carbamoyltransferase; Validated; Region: PRK02102 418127007983 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 418127007984 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 418127007985 arginine deiminase; Provisional; Region: PRK01388 418127007986 Arginine repressor [Transcription]; Region: ArgR; COG1438 418127007987 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 418127007988 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 418127007989 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 418127007990 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 418127007991 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 418127007992 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 418127007993 active site 418127007994 Zn binding site [ion binding]; other site 418127007995 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 418127007996 HTH domain; Region: HTH_11; pfam08279 418127007997 PRD domain; Region: PRD; pfam00874 418127007998 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 418127007999 active site 418127008000 P-loop; other site 418127008001 phosphorylation site [posttranslational modification] 418127008002 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127008003 active site 418127008004 phosphorylation site [posttranslational modification] 418127008005 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 418127008006 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 418127008007 active site 418127008008 P-loop; other site 418127008009 phosphorylation site [posttranslational modification] 418127008010 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 418127008011 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127008012 active site 418127008013 phosphorylation site [posttranslational modification] 418127008014 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 418127008015 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 418127008016 Predicted membrane protein [Function unknown]; Region: COG1511 418127008017 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 418127008018 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 418127008019 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 418127008020 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 418127008021 CHAP domain; Region: CHAP; pfam05257 418127008022 Isochorismatase family; Region: Isochorismatase; pfam00857 418127008023 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 418127008024 catalytic triad [active] 418127008025 conserved cis-peptide bond; other site 418127008026 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 418127008027 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 418127008028 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 418127008029 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 418127008030 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 418127008031 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 418127008032 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 418127008033 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 418127008034 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 418127008035 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 418127008036 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 418127008037 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 418127008038 SecY translocase; Region: SecY; pfam00344 418127008039 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 418127008040 legume lectins; Region: lectin_L-type; cd01951 418127008041 homotetramer interaction site [polypeptide binding]; other site 418127008042 carbohydrate binding site [chemical binding]; other site 418127008043 metal binding site [ion binding]; metal-binding site 418127008044 Putative Ig domain; Region: He_PIG; pfam05345 418127008045 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 418127008046 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 418127008047 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 418127008048 methionine sulfoxide reductase A; Provisional; Region: PRK05528 418127008049 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 418127008050 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127008051 Coenzyme A binding pocket [chemical binding]; other site 418127008052 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 418127008053 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 418127008054 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 418127008055 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 418127008056 Chain length determinant protein; Region: Wzz; cl15801 418127008057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 418127008058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 418127008059 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 418127008060 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 418127008061 DXD motif; other site 418127008062 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 418127008063 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 418127008064 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 418127008065 Acyltransferase family; Region: Acyl_transf_3; pfam01757 418127008066 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 418127008067 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 418127008068 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 418127008069 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 418127008070 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 418127008071 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 418127008072 metal binding site [ion binding]; metal-binding site 418127008073 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 418127008074 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 418127008075 substrate binding site [chemical binding]; other site 418127008076 glutamase interaction surface [polypeptide binding]; other site 418127008077 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 418127008078 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 418127008079 catalytic residues [active] 418127008080 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 418127008081 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 418127008082 putative active site [active] 418127008083 oxyanion strand; other site 418127008084 catalytic triad [active] 418127008085 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 418127008086 putative active site pocket [active] 418127008087 4-fold oligomerization interface [polypeptide binding]; other site 418127008088 metal binding residues [ion binding]; metal-binding site 418127008089 3-fold/trimer interface [polypeptide binding]; other site 418127008090 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 418127008091 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 418127008092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127008093 homodimer interface [polypeptide binding]; other site 418127008094 catalytic residue [active] 418127008095 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 418127008096 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 418127008097 NAD binding site [chemical binding]; other site 418127008098 dimerization interface [polypeptide binding]; other site 418127008099 product binding site; other site 418127008100 substrate binding site [chemical binding]; other site 418127008101 zinc binding site [ion binding]; other site 418127008102 catalytic residues [active] 418127008103 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 418127008104 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 418127008105 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 418127008106 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 418127008107 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 418127008108 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 418127008109 putative active site [active] 418127008110 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 418127008111 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 418127008112 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 418127008113 Walker A/P-loop; other site 418127008114 ATP binding site [chemical binding]; other site 418127008115 ABC transporter; Region: ABC_tran; pfam00005 418127008116 Q-loop/lid; other site 418127008117 ABC transporter signature motif; other site 418127008118 Walker B; other site 418127008119 D-loop; other site 418127008120 H-loop/switch region; other site 418127008121 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 418127008122 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 418127008123 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 418127008124 Walker A/P-loop; other site 418127008125 ATP binding site [chemical binding]; other site 418127008126 Q-loop/lid; other site 418127008127 ABC transporter signature motif; other site 418127008128 Walker B; other site 418127008129 D-loop; other site 418127008130 H-loop/switch region; other site 418127008131 hypothetical protein; Provisional; Region: PRK13661 418127008132 Uncharacterized conserved protein [Function unknown]; Region: COG1912 418127008133 Uncharacterized conserved protein [Function unknown]; Region: COG2353 418127008134 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 418127008135 Strictosidine synthase; Region: Str_synth; pfam03088 418127008136 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 418127008137 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 418127008138 active site residue [active] 418127008139 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 418127008140 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 418127008141 putative substrate binding pocket [chemical binding]; other site 418127008142 AC domain interface; other site 418127008143 catalytic triad [active] 418127008144 AB domain interface; other site 418127008145 interchain disulfide; other site 418127008146 hypothetical protein; Validated; Region: PRK07668 418127008147 Predicted transcriptional regulators [Transcription]; Region: COG1695 418127008148 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 418127008149 DinB superfamily; Region: DinB_2; pfam12867 418127008150 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 418127008151 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 418127008152 transmembrane helices; other site 418127008153 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 418127008154 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 418127008155 Predicted permeases [General function prediction only]; Region: RarD; COG2962 418127008156 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 418127008157 hypothetical protein; Provisional; Region: PRK07758 418127008158 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 418127008159 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 418127008160 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 418127008161 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 418127008162 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 418127008163 Walker A/P-loop; other site 418127008164 ATP binding site [chemical binding]; other site 418127008165 Q-loop/lid; other site 418127008166 ABC transporter signature motif; other site 418127008167 Walker B; other site 418127008168 D-loop; other site 418127008169 H-loop/switch region; other site 418127008170 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 418127008171 FtsX-like permease family; Region: FtsX; pfam02687 418127008172 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 418127008173 DNA-binding site [nucleotide binding]; DNA binding site 418127008174 RNA-binding motif; other site 418127008175 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 418127008176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127008177 non-specific DNA binding site [nucleotide binding]; other site 418127008178 salt bridge; other site 418127008179 sequence-specific DNA binding site [nucleotide binding]; other site 418127008180 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 418127008181 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 418127008182 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 418127008183 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 418127008184 ParB-like nuclease domain; Region: ParBc; pfam02195 418127008185 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 418127008186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 418127008187 S-adenosylmethionine binding site [chemical binding]; other site 418127008188 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 418127008189 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 418127008190 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 418127008191 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 418127008192 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 418127008193 trmE is a tRNA modification GTPase; Region: trmE; cd04164 418127008194 G1 box; other site 418127008195 GTP/Mg2+ binding site [chemical binding]; other site 418127008196 Switch I region; other site 418127008197 G2 box; other site 418127008198 Switch II region; other site 418127008199 G3 box; other site 418127008200 G4 box; other site 418127008201 G5 box; other site 418127008202 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 418127008203 ribonuclease P; Reviewed; Region: rnpA; PRK00499 418127008204 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399