-- dump date 20140620_074430 -- class Genbank::CDS -- table cds_note -- id note NP_370525.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. NP_370526.1 binds the polymerase to DNA and acts as a sliding clamp NP_370528.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA NP_370532.2 catalyzes the degradation of histidine to urocanate and ammmonia NP_370533.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_370534.1 similar to amino acid permease NP_370536.1 similar to homoserine-o-acetyltransferase NP_370539.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk NP_370541.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis NP_370548.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA NP_370574.1 transposon Tn554 NP_370575.1 similar to HMG-CoA synthase NP_370578.1 Tn554 NP_370579.1 Tn554 NP_370580.1 Tn554 NP_370590.1 Staphylococcus aureus IS150-fragment NP_370591.1 Staphylococcus aureus IS150 NP_370592.1 similar to transposase NP_370594.1 SCCmec; similar to kdp operon transcriptional regulatory protein NP_370595.1 SCCmec; similar to kdp operon sensor protein NP_370596.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions NP_370597.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions NP_370598.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex NP_370605.1 similar to serine/threonine protein kinase NP_370612.1 PRO1975 protein; similar to homo sapiens CGI-44 protein NP_370617.1 similar to DNA helicase NP_370625.1 similar to transcription regulator AraC/XylS family NP_370626.1 similar to aminoacylase NP_370627.1 similar to transmembrane efflux pump protein NP_370630.1 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever NP_370632.1 similar to transcription regulator GntR family NP_370640.1 similar to cysteine synthase NP_370641.1 similar to ornithine cyclodeaminase NP_370643.1 similar to multi-drug resistance efflux pump NP_370644.1 similar to rhizobactin siderophore biosynthesisprotein RhsC NP_370645.1 similar to rhizobactin siderophore biosynthesisprotein RhsF NP_370646.1 similar to various aldolase NP_370647.1 similar to diaminopimelate decarboxylase NP_370652.1 similar to UDP-glucose 4-epimerase NP_370653.1 similar to glycosyltransferase TuaA NP_370654.1 similar to exopolysaccharide EpsG NP_370655.1 similar to capsular polysaccharide synthesis protein 14H NP_370656.1 similar to capsular polysaccharide synthesis protein 14L NP_370659.1 similar to trehalose operon transcriptional repressor NP_370660.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate NP_370661.1 similar to tetracyclin resistance protein NP_370662.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate NP_370663.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose NP_370664.1 similar to phosphonates transport permease NP_370665.1 similar to phosphonates transport permease NP_370666.1 similar to transport system protein NP_370667.1 similar to alkylphosphonate ABC tranporter NP_370669.1 similar to lactococcal phosphatase homolog NP_370671.1 similar to DNA-binding protein NP_370689.1 iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source NP_370692.1 similar to cation-efflux system membrane protein CzcD NP_370695.1 similar to alpha-helical coiled-coil protein SrpF NP_370696.1 similar to nitrate transporter NP_370697.1 similar to membrane lipoprotein SrpL NP_370698.1 similar to probable permease of ABC transporter NP_370699.1 similar to acyl-CoA dehydrogenase family protein NP_370701.1 Catalyzes the reversible two-electron oxidation of formate to carbon dioxide. It allows the assimilation of carbon dioxide and provides energy for growth through oxidative phosphorylation coupled to the reduction of oxygen, nitrate, sulphate or fumarate NP_370702.1 similar to integral membrane protein LmrP NP_370703.1 similar to surfactin synthetase NP_370706.1 similar to N-acetylglutamate 5-phosphotransferase NP_370707.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate NP_370708.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate NP_370710.1 similar to branched-chain amino acid transport system carrier protein NP_370711.1 similar to isochorismatase NP_370712.1 similar to indole-3-pyruvate decarboxylas NP_370713.1 glucose-specific, factor IIA homolog NP_370715.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway NP_370716.1 similar to sucrose phosphotransferase enzyme II NP_370717.1 similar to transcription regulator NP_370722.1 similar to ABC transporter ATP-binding protein NP_370723.1 similar to Enterococcus faecalis plasmid pPD1 bacI NP_370727.1 similar to ABC transporter ATP-binding protein NP_370730.1 similar to peptide ABC transporter permease NP_370731.1 similar to dipeptide transporter protein dppC NP_370733.1 similar to gamma-glutamyltranspeptidase precursor NP_370735.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds NP_370736.1 similar to lysostaphin precursor NP_370738.1 similar to maltose/maltodextrin-binding protein NP_370741.1 similar to NADH-dependent dehydrogenase NP_370742.1 similar to NADH-dependent dehydrogenase NP_370747.1 similar to two-component response regulator NP_370748.1 similar to two-component sensor histidine kinase NP_370749.1 similar to periplasmic-iron-binding protein BitC NP_370752.1 similar to glycerophosphodiester phosphodiesterase NP_370756.1 similar to 3-hydroxyacyl-CoA dehydrogenase NP_370757.1 similar to glutaryl-CoA dehydrogenase NP_370758.1 similar to acid-CoA ligase NP_370761.1 similar to nickel ABC transporter nickel-binding protein NP_370764.1 similar to flavohemoprotein NP_370766.1 maltose- and glucose-specific factor II homolog NP_370767.1 similar to inosine-uridine preferring nucleoside hydrolase NP_370768.1 similar to BglG antiterminator family NP_370769.1 similar to PTS fructose-specific enzyme IIBC component NP_370770.1 similar to PTS, galactitol-specific IIB component NP_370775.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers NP_370776.1 similar to xylitol dehydrogenase NP_370777.1 similar to teichoic acid biosynthesis protein B NP_370778.1 similar to teichoic acid biosynthesis protein F NP_370779.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers NP_370780.1 similar to D-xylulose reductase NP_370781.1 similar to teichoic acid biosynthesis protein B NP_370782.1 similar to beta-glycosyltransferase NP_370783.1 involved in peptidoglycan cross-linking NP_370786.1 negatively regulates murein hydrolase activity NP_370787.1 in conjunction with LrgA this protein inhibits the expression or activity of extracellular murein hydrolases NP_370788.1 similar to transcription regulator GntR family NP_370789.1 similar to PTS beta-glucoside-specific enzyme II ABC component NP_370793.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source NP_370794.1 similar to ribose transporter RbsU NP_370795.1 similar to rbs operon repressor RbsR NP_370798.1 similar to proton antiporter efflux pump NP_370799.1 similar to penicillin amidase V NP_370805.1 similar to secretory antigen precursor SsaA NP_370807.1 similar to transmembrane protein Tmp7 NP_370829.1 similar to formate transporter NirC NP_370830.1 similar to branched-chain amino acid uptake carrier NP_370831.1 similar to outer membrane protein precursor NP_370833.1 similar to ABC transporter ATP-binding protein NP_370834.1 similar to regulatory protein PfoR NP_370835.1 similar to carbohydrate kinase PfkB family NP_370838.1 similar to sodium-coupled permease NP_370839.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid NP_370840.1 similar to glucokinase NP_370842.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate NP_370846.1 similar to trimethylamine dehydrogenase NP_370847.1 similar to alkanal monooxygenase alpha chain NP_370848.1 similar to glycine cleavage system H protein NP_370851.1 similar to lipoate-protein ligase NP_370852.1 similar to dihydroflavonol-4-reductase NP_370853.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr NP_370855.1 similar to PTS fructose-specific enzyme IIBC component NP_370856.1 similar to transcription antiterminator BglG family NP_370857.1 similar to transcription regulator NP_370864.1 similar to NADH-dependent FMN reductase NP_370866.1 similar to ribosomal-protein-serine N-acetyltransferase NP_370873.1 similar to transcriptional repressor NP_370875.1 similar to ABC transporter ATP-binding protein NP_370877.1 similar to low temperature requirement A protein NP_370880.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine NP_370881.1 catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions NP_370882.1 similar to cystathionine beta-lyase NP_370883.1 similar to cystathionine gamma-synthase NP_370884.1 similar to transcription terminator NP_370887.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 NP_370889.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 NP_370891.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit NP_370892.1 similar to hypothetical protein virulence plasmid pXO1-38 NP_370894.1 similar to exotoxin 2 NP_370900.1 similar to phosphoglycerate mutase Gpm3p NP_370906.1 similar to nitro/flavin reductase NP_370907.1 similar to proton/sodium-glutamate symport protein NP_370912.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine NP_370915.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway NP_370937.1 similar to DNA helicase NP_370939.1 similar to IS905 NP_370940.1 Pathogenicity island SaPIn2 NP_370941.1 Pathogenicity island SaPIn2 NP_370942.1 Pathogenicity island SaPIn2 NP_370943.1 Pathogenicity island SaPIn2 NP_370944.1 Pathogenicity island SaPIn2 NP_370945.1 Pathogenicity island SaPIn2 NP_370946.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_370947.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_370948.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_370949.1 SSL5, SET3, SET10; bind P-selectin glycoprotein ligand-1 and inhibit P-selectin-mediated neutrophil rolling along the endothelium; these proteins share structural homology to known superantigens but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_370950.1 SSL7, SET1; blocks IgA-FcR interactions and inhibits complement, leading to increased survival of a sensitive bacterium in blood NP_370951.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_370952.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_370953.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_370954.1 Pathogenicity island SaPIn2 NP_370955.1 Pathogenicity island SaPIn2 NP_370956.1 Pathogenicity island SaPIn2 NP_370957.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_370958.1 Pathogenicity island SaPIn2 NP_370960.1 Pathogenicity island SaPIn2; SAV0436 NP_370961.1 Pathogenicity island SaPIn2; SAV0437 NP_370962.1 Pathogenicity island SaPIn2; SAV0438 NP_370963.1 Pathogenicity island SaPIn2 NP_370965.1 Pathogenicity island SaPIn2 NP_370966.1 Pathogenicity island SaPIn2 NP_370967.1 Pathogenicity island SaPIn2 NP_370968.1 Pathogenicity island SaPIn2 NP_370969.1 Pathogenicity island SaPIn2 NP_370976.1 Catalyzes the transfer of electrons from NADH to ubiquinone NP_370981.1 similar to carboxylesterase NP_370982.1 similar to sodium-dependent transporter NP_370986.1 similar to ABC transporter ATP-binding protein NP_370987.1 similar to ABC transporter permease protein NP_370988.1 similar to lactococcal lipoprotein NP_370997.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate NP_371000.1 similar to trehalose operon transcriptional repressor NP_371004.1 involved in a recombinational process of DNA repair, independent of the recBC complex NP_371005.1 similar to lysine decarboxylase NP_371006.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) NP_371009.1 similar to signal peptidase II homolog NP_371010.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA NP_371014.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content NP_371017.2 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin NP_371019.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis NP_371022.2 stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus NP_371023.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis NP_371024.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP NP_371025.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response NP_371026.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation NP_371028.1 similar to low temperature requirement B protein NP_371029.1 MazG NP_371030.1 Hsp15 NP_371031.1 similar to cell-division initiation protein NP_371032.1 similar to polyribonucleotide nucleotidyltransferase NP_371035.1 ATP-dependent Zn metallopeptidase NP_371036.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers NP_371041.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 NP_371042.1 similar to transcription regulator GntR family NP_371043.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate NP_371044.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate NP_371048.1 similar to creatine kinase NP_371050.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents NP_371052.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation NP_371054.2 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA NP_371055.1 similar to tRNA/rRNA methyltransferase NP_371058.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force NP_371061.1 binds directly to 23S ribosomal RNA NP_371062.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA NP_371063.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit NP_371064.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors NP_371066.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme NP_371067.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter NP_371068.1 in Bacillus subtilis this non-essential protein associates with the ribosome NP_371069.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance NP_371070.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit NP_371071.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene NP_371072.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu NP_371073.1 similar to N-acyl-L-amino acid amidohydrolase NP_371074.2 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine NP_371075.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress NP_371076.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate NP_371077.1 similar to UDP-glucose 4-epimerase related protein NP_371078.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids NP_371080.1 similar to deoxypurine kinase NP_371081.1 similar to deoxypurine kinase NP_371082.1 similar to Cu binding protein (Mn oxidation) NP_371088.1 similar to poly (glycerol-phosphate) alpha-glucosyltransferase for teichoic acid biosynthesis NP_371089.1 similar to poly (glycerol-phosphate) alpha-glucosyltransferase for teichoic acid biosynthesis NP_371090.1 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis NP_371094.1 similar to hexulose-6-phosphate synthase NP_371096.1 similar to indigoidine systhesis protein NP_371104.1 similar to phosphomethylpyrimidine kinase ThiD NP_371105.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine NP_371108.1 similar to cationic amino acid transporter NP_371112.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta NP_371124.1 similar to oxidoreductase of ion channel NP_371129.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs NP_371131.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase NP_371132.1 similar to endonuclease III NP_371133.1 similar to iron-binding protein NP_371134.1 similar to iron(III) ABC transporter permease protein NP_371135.1 similar to L-2-haloalkanoic acid dehalogenase NP_371136.1 similar to 2-hydroxy-6-oxo-6-phenylhexa-2, 4-dienoic acid hydrolase NP_371139.1 similar to esterase/lipase NP_371144.1 similar to FimE recombinase NP_371145.2 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_371147.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_371148.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_371149.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; in S. meliloti it is known to be involved specifically with K+ transport NP_371150.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport NP_371151.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_371152.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_371155.1 Streptococcal adhesin PsaA homolog NP_371157.1 similar to ABC transporter ATP-binding protein NP_371158.1 similar to iron dependent repressor NP_371161.1 with TagG is involved in the export of teichoic acids NP_371169.1 similar to pyrimidine nucleoside transporter NP_371174.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase NP_371179.1 similar to lipase LipA NP_371183.1 similar to two-component response regulator NP_371184.1 similar to two-component sensor histidine kinase NP_371188.1 similar to low-affinity inorganic phosphate transporter NP_371191.1 similar to AraC/XylS family transcriptional regulator NP_371196.1 similar to LysR family transcriptional regulator NP_371197.1 similar to sugar efflux transpoter NP_371207.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters UDP disphosphate which reduces the pool of lipid carrier available to the cell NP_371208.1 similar to ABC transporter required for expression of cytochrome bd NP_371209.1 similar to ABC transporter required for expression of cytochrome bd NP_371210.1 similar to transcriptional regulator NP_371211.1 similar to cobalamin synthesis related protein NP_371212.1 similar to aryl-alcohol dehydrogenase NP_371215.1 similar to deoxyribodipyrimidine photolyase NP_371221.1 similar to transcription regulation protein NP_371222.1 similar to transcription repressor of fructose operon NP_371226.1 similar to hemolysin homolog NP_371227.1 similar to plant-metabolite dehydrogenases NP_371228.1 similar to CsbB stress response protein NP_371237.1 similar to anthranilate synthase component II NP_371238.1 similar to para-aminobenzoate synthase component I NP_371239.1 similar to para-aminobenzoate synthase component I NP_371241.1 similar to urea amidolyase NP_371243.1 similar to anion-binding protein NP_371244.1 similar to ABC transporter ATP-binding protein NP_371246.1 similar to choline transport ATP-binding protein NP_371247.1 similar to choline transporter NP_371248.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis NP_371250.1 similar to multidrug resistance protein NP_371251.1 similar to di-tripepride ABC transporter NP_371252.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis NP_371254.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF NP_371255.1 Catalyzes the rate-limiting step in dNTP synthesis NP_371256.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE NP_371257.1 similar to ferrichrome ABC transporter permease NP_371258.1 similar to ferrichrome ABC transporter permease NP_371259.1 similar to ferrichrome ABC transporter ATP-binding protein NP_371260.1 similar to ferrichrome ABC transporter NP_371262.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis NP_371266.1 similar to glycerate kinase NP_371267.1 catalyzes the release of the N-terminal amino acid from a tripeptide NP_371274.1 similar to comF operon protein 1 NP_371275.1 similar to comF operon protein 3 NP_371277.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins NP_371278.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 NP_371282.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion NP_371283.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate NP_371284.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system NP_371285.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein NP_371286.1 similar to O-acetyltransferase NP_371292.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates NP_371293.1 similar to cell-division inhibitor NP_371297.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway NP_371298.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate NP_371299.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate NP_371300.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_371306.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation NP_371307.1 similar to excisionase NP_371324.1 ; similar to bacteriophage terminase small subunit NP_371327.1 similar to ferrichrome ABC transporter fhuD precursor NP_371328.1 similar to tetracenomycin C synthesis protein NP_371336.1 similar to staphylocoagulase precursor NP_371338.1 similar to extracellular matrix and plasma binding protein NP_371348.1 similar to phosphoglycerate mutase NP_371350.1 similar to lactococcal prophage ps3 protein 05 NP_371352.1 similar to general stress protein 170 NP_371353.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis NP_371355.1 similar to thioredoxin NP_371356.1 similar to arsenate reductase NP_371357.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor NP_371360.1 similar to thioredoxin NP_371369.1 similar to nitrogen fixation protein NifU NP_371408.1 similar to int gene activator NP_371409.1 similar to terminase small subunit NP_371410.1 similar to phage-related terminase large subunit NP_371416.1 similar to major capsid protein NP_371422.1 similar to major tail protein NP_371443.1 similar to hemolysin NP_371444.1 similar to 2-nitropropane dioxygenase NP_371448.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group NP_371453.1 similar to N-acetyl-glucosamine catabolism homolog NP_371454.1 similar to glycerate dehydrogenase NP_371456.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid NP_371458.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid NP_371460.1 similar to nitrogen fixation protein NifU NP_371462.1 similar to NADH dehydrogenase NP_371465.1 similar to NADH dehydrogenase NP_371470.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_371471.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_371472.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_371473.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone NP_371474.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_371475.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in the case of S. meliloti it was proved to be involved specifically with K+ transport NP_371476.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_371479.1 similar to polyribonucleotide nucleotidyltransferase NP_371480.1 similar to NADH-dependent flavin oxidoreductase NP_371484.1 catalyzes the formation of arginine from (N-L-arginino)succinate NP_371485.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming NP_371486.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family NP_371490.1 similar to ATP-dependent nuclease subunit B NP_371491.1 similar to ATP-dependent nuclease subunit A NP_371492.1 similar to 5-oxo-1,2,5-tricarboxilic-3-penten acid decarboxylase NP_371494.1 NADPH-dependent; catalyzes the reduction of coenzyme A disulfide NP_371498.1 similar to lipopolysaccharide modification acyltransferase NP_371500.1 similar to transcription regulator LysR family NP_371501.1 similar to 2-isopropylmalate synthase NP_371505.1 similar to cell surface protein Map-w NP_371507.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs NP_371508.1 similar to 3-oxoacyl-(acyl-carrier-protein) synthase NP_371511.1 similar to oligopeptide transport system permease protein OppC NP_371514.1 similar to peptide binding protein OppA NP_371515.1 similar to peptide ABC transporter oligopeptide-binding protein NP_371519.1 similar to oligopeptide transport system permease protein OppC NP_371520.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_371521.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress NP_371522.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence NP_371523.1 similar to transcription factor NP_371531.1 catalyzes the phosphorylation of NAD to NADP NP_371533.1 similar to Mg2+ transporter NP_371535.1 Catalyzes a key regulatory step in fatty acid biosynthesis NP_371537.1 similar to Na+/H+-dependent alanine carrier protein NP_371539.1 similar to 2'-5' RNA ligase NP_371540.1 similar to multidrug resistance protein-related protein NP_371541.1 processive; catalyzes the formation of mono-, di- and tri-glucosyldiacylglycerol by the progressive transfer of glucosyl residues to diacylglycerol; involved in the formation of membrane glycolipids NP_371542.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine NP_371548.1 similar to Na+-transporting ATP synthase NP_371549.1 similar to nucleotidase NP_371550.1 similar to competence transcription factor NP_371556.1 similar to lactococcin 972 NP_371557.1 similar to lactococcin 972 immunity factor NP_371562.1 similar to ferrichrome ABC transporter NP_371565.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate NP_371566.1 similar to menaquinone-specific isochorismate synthase NP_371569.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA NP_371572.1 V8 protease, glutamyl endopeptidase NP_371575.1 probable ATL autolysin transcription regulator NP_371576.2 truncated-atl NP_371582.1 similar to quinol oxidase polypeptide IV QoxD NP_371585.1 similar to quinol oxidase polypeptide II QoxA NP_371586.1 similar to chitinase B NP_371587.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate NP_371588.1 similar to phosphoribosylaminoimidazole carboxylase PurE NP_371589.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway NP_371590.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase NP_371592.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis NP_371593.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis NP_371594.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway NP_371595.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis NP_371597.1 involved in de novo purine biosynthesis NP_371598.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis NP_371600.1 similar to cation ABC transporter NP_371607.1 phosphohistidin-containing protein NP_371615.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_371620.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide NP_371623.1 ATP-binding protein homolog NP_371629.1 similar to Mn2+-transport protein NP_371636.1 depletion of this protein in Bacillus subtilis results in defects in cell morphology; crystal structure of Staphylococcus protein shows homodimer; ligand binding protein NP_371638.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate NP_371639.1 similar to heme synthase NP_371640.1 converts protoheme IX and farnesyl diphosphate to heme O NP_371645.1 similar to glycerophosphoryl diester phosphodiesterase NP_371649.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA NP_371652.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not NP_371657.1 similar to ferrichrome ABC transporter NP_371658.1 similar to ferrichrome ABC transporter NP_371660.2 iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source NP_371661.1 similar to rRNA methylase NP_371662.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily NP_371663.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily NP_371664.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids NP_371668.1 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange NP_371670.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision NP_371672.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol NP_371673.2 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase NP_371675.1 converts L-glutamate to D-glutamate, a component of peptidoglycan NP_371676.1 hydrolyzes non-standard nucleotides such as xanthine and inosine NP_371679.1 similar to fibrinogen-binding protein NP_371680.1 FLIPr; secreted protein that blocks the formyl peptide receptor-like 1 (FPRL1) found in neutrophils, monocytes, B cells, and NK cells; inhibits the binding of chemoattractants (such as formylated peptides) to FPRL1, which initiates the phagocyte mobilization towards the infection site NP_371682.1 similar to fibrinogen-binding protein NP_371683.1 similar to fibrinogen-binding protein NP_371690.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_371691.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_371692.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_371693.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation NP_371694.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP NP_371702.1 MraZ; UPF0040; crystal structure shows similarity to AbrB NP_371706.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan NP_371707.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation NP_371708.1 FtsQ homolog NP_371710.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function NP_371715.1 similar to cell-division protein NP_371716.1 similar to cell-divisio initiation protein NP_371717.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme NP_371720.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis NP_371722.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity NP_371724.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis NP_371725.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis NP_371726.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers NP_371727.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity NP_371728.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase NP_371729.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate NP_371732.1 similar to fibrinogen binding protein NP_371733.1 Essential for recycling GMP and indirectly, cGMP NP_371734.1 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits NP_371739.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_371741.1 similar to RNA-binding Sun protein NP_371742.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance NP_371748.1 required for 70S ribosome assembly NP_371751.1 catalyzes branch migration in Holliday junction intermediates NP_371752.1 negative regulator of genes involved in fatty acid and phospholipid biosynthesis for gram positive bacteria NP_371753.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY NP_371756.1 carries the fatty acid chain in fatty acid biosynthesis NP_371757.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity NP_371762.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity NP_371763.1 Essential for efficient processing of 16S rRNA NP_371764.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA NP_371765.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site NP_371767.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) NP_371768.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids NP_371769.1 catalyzes the interconversion of succinyl-CoA and succinate NP_371770.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle NP_371773.1 similar to DNA processing Smf protein NP_371774.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity NP_371775.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine NP_371777.1 heat shock protein involved in degradation of misfolded proteins NP_371778.1 heat shock protein involved in degradation of misfolded proteins NP_371779.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor NP_371780.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit NP_371781.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu NP_371782.1 Catalyzes the phosphorylation of UMP to UDP NP_371783.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs NP_371784.1 catalyzes the formation of UDP pyrophosphate from isopentenyl pyrophosphate NP_371787.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) NP_371788.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity NP_371789.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins NP_371790.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination NP_371792.1 similar to ribosomal protein L7AE family NP_371793.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex NP_371794.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock NP_371795.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs NP_371797.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence NP_371801.1 similar to transcription regulator GntR family NP_371802.1 similar to processing proteinase homolog NP_371803.1 similar to precessing proteinase NP_371804.1 similar to 3-oxoacyl- acyl-carrier protein reductase homolog ymfI NP_371809.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs NP_371810.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP NP_371813.1 similar to 2-oxoacid ferredoxin oxidoreductase alpha subunit NP_371814.1 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin NP_371816.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) NP_371819.2 This protein performs the mismatch recognition step during the DNA repair process NP_371821.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex NP_371825.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP NP_371827.1 similar to lysophospholipase NP_371828.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity NP_371829.1 similar to host factor-1 NP_371831.1 similar to GTP-binding protein proteinase modulator homolog ynbA NP_371832.1 similar to aluminum resistance protein NP_371842.1 ATP-binding protein NP_371843.2 ATP-binding protein NP_371844.1 similar to ABC transporter integral membrane protein NP_371845.1 similar to two-component sensor histidine kinase NP_371846.1 similar to two-component response regulator NP_371851.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive NP_371852.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine NP_371853.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine NP_371854.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate NP_371859.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_371860.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif NP_371861.1 similar to GMP reductase NP_371863.1 Represses a number of genes involved in the response to DNA damage NP_371869.1 similar to exonuclease SbcD NP_371870.1 similar to exonuclease SbcC NP_371871.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock NP_371874.1 Catalyzes the conversion of citrate to isocitrate NP_371878.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_371879.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_371880.1 sodium/alanine symporter NP_371885.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress NP_371888.1 similar to DNA-damage repair protein NP_371889.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate NP_371890.1 similar to glucanase NP_371891.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine NP_371893.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate NP_371894.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water NP_371895.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis NP_371896.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate NP_371897.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis NP_371908.1 similar to oligoendopeptidase NP_371909.1 similar to negative regulator PhoU NP_371910.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation NP_371911.1 similar to phosphate ABC transporter NP_371912.1 similar to phosphate ABC transporter NP_371916.1 ATP-binding protein NP_371917.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. NP_371919.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis NP_371920.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis NP_371923.1 similar to alanine racemase NP_371928.1 catalyzes the hydrolysis of acylphosphate NP_371929.1 similar to 5-bromo-4-chloroindolyl phosphate hydrolysis protein xpaC NP_371930.1 similar to tellurite resistance protein NP_371933.1 similar to nitric-oxide reductase NP_371936.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA NP_371937.2 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide NP_371942.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis NP_371947.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress NP_371948.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress NP_371951.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived NP_371957.1 similar to cell wall enzyme EbsB NP_371958.1 similar to streptococcal adhesin emb NP_371959.1 similar to streptococcal adhesin emb NP_371961.1 similar to amino acid pearmease NP_371962.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic NP_371964.1 similar to 5'-3' exonuclease NP_371973.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC NP_371977.1 similar to chromosome replication initiation protein dnaD NP_371978.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_371980.1 similar to bifunctional biotin ligase/biotin operon repressor NP_371981.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity NP_371982.1 similar to lipopolysaccharide biosynthesis-related protein NP_371988.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis NP_371989.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis NP_371990.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis NP_371993.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate NP_371995.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone NP_371996.1 similar to component A of hexaprenyl diphosphate synthase NP_371997.1 HB (HU) NP_371998.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate NP_371999.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains NP_372000.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins NP_372002.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP NP_372004.1 similar to thioredoxin reductase homolog NP_372026.1 similar to oxidoreductase NP_372027.1 similar to pyrroline-5-carboxylate reductase NP_372029.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate NP_372034.1 similar to export protein SpcT protein NP_372035.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate NP_372036.1 similar to tripeptidase NP_372044.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes NP_372046.1 catalyzes the bidirectional exonucleolytic cleavage of DNA NP_372047.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides NP_372048.1 Regulates rRNA biosynthesis by transcriptional antitermination NP_372050.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism NP_372052.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA NP_372059.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein NP_372060.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein NP_372061.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein NP_372062.1 similar to shikimate kinase NP_372063.1 similar to ComYC protein NP_372065.1 similar to competence protein NP_372067.1 similar to DNA transport machinery protein comGB NP_372068.1 similar to late competence protein comGA NP_372075.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_372079.1 similar to ABC transporter NP_372080.1 similar to ABC transporter ATP-binding protein NP_372081.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues NP_372082.1 similar to ATP-dependent RNA helicase NP_372085.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium NP_372089.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_372090.1 similar to DNA repair protein RecO NP_372091.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome NP_372093.1 similar to diacylglycerol kinase NP_372099.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA NP_372101.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase NP_372102.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype NP_372103.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion NP_372104.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria NP_372105.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor NP_372107.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III NP_372109.1 binds to the ribosome on the universally-conserved alpha-sarcin loop NP_372110.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase NP_372111.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA NP_372112.1 similar to ComEC late competence protein 3 NP_372114.1 similar to late competence operon required for DNA binding and uptake comEA NP_372121.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis NP_372126.1 similar to enterotoxin A precursor NP_372130.1 accC homolog; biotin carboxylase subunit NP_372131.1 similar to acetyl-CoA carboxylase biotin carboxyl carrier subunit accB NP_372134.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus NP_372135.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor NP_372136.1 similar to protease NP_372137.1 similar to protease NP_372138.1 similar to caffeoyl-CoA O-methyltransferase NP_372140.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function NP_372142.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_372143.1 similar to deoxyribonuclease NP_372145.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs NP_372154.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes NP_372155.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG NP_372157.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine NP_372159.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis NP_372160.1 similar to single-strand DNA-specific exonuclease NP_372161.1 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF NP_372163.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) NP_372164.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step NP_372165.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration NP_372166.1 plays an essential role in ATP-dependent branch migration of the Holliday junction NP_372167.1 similar to chorismate mutase NP_372168.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication NP_372169.2 involved in the peptidyltransferase reaction during translation NP_372171.1 BL20 NP_372172.1 similar to cell shape determinant mreD NP_372173.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall NP_372176.1 similar to transporter PAB2175 from Pyrococcus abyssi NP_372177.1 Staphylococcus aureus transposon Tn554 NP_372181.1 Tn554 NP_372182.1 Tn554 NP_372183.1 Tn554 NP_372184.1 Tn554 inserted NP_372185.1 similar to type IV prepilin peptidase NP_372187.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain NP_372191.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway NP_372192.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate NP_372194.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis NP_372196.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins NP_372197.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential NP_372198.1 binds and unfolds substrates as part of the ClpXP protease NP_372199.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer NP_372202.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit NP_372204.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits NP_372207.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) NP_372208.1 Primosomal protein that may act to load helicase DnaC during DNA replication NP_372212.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis NP_372213.1 similar to formamidopyrimidine-DNA glycosylase NP_372218.1 Converts isocitrate to alpha ketoglutarate NP_372219.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate NP_372222.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis NP_372223.1 insertion sequence IS1181 NP_372224.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein NP_372225.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits NP_372231.1 catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins NP_372235.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA NP_372237.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein NP_372239.1 Required for the synthesis of the thiazole moiety NP_372240.1 similar to iron-sulfur cofactor synthesis protein nifZ NP_372241.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation NP_372243.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination NP_372244.1 insertion sequence IS1181 NP_372245.1 similar to glycerophosphoryl diester phosphodiesterase NP_372247.1 similar to soluble hydrogenase 42 kD subunit NP_372248.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate NP_372251.1 similar to acylglycerol-3-phosphate O-acyltransfera homolog NP_372252.1 similar to serine proteinase Do, heat-shock protein htrA NP_372256.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate NP_372257.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA NP_372261.1 catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate NP_372262.1 similar to smooth muscle caldesmon NP_372263.1 similar to general stress protein homolog NP_372264.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis NP_372266.1 beta subunit NP_372272.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine NP_372275.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases NP_372277.1 similar to 16S pseudouridylate synthase NP_372284.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase NP_372291.2 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not NP_372294.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine NP_372305.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity NP_372307.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling NP_372314.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase NP_372315.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP NP_372320.1 OSB NP_372323.1 similar to latent nuclear antigen [Kaposi's sarcoma-associated herpesvirus] NP_372356.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX NP_372357.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic NP_372358.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III NP_372360.1 similar to ABC transporter ecsB NP_372366.1 catalyzes the exonucleic cleavage of mRNA yielding nucleioside 5'-phosphates NP_372375.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle NP_372382.1 similar to glutamine-binding periplasmic protein NP_372383.1 similar to regulatory protein (pfoS/R) NP_372384.1 Insertion sequence IS1181 NP_372386.1 similar to D-3-phosphoglycerate dehydrogenase NP_372388.1 converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate NP_372390.1 ATP-binding protein NP_372392.1 similar to A/G-specific adenine glycosylase NP_372394.1 similar to teichoic acid transport protein tagG NP_372395.1 similar to teichoic acid translocation ATP-binding protein tagH NP_372397.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities NP_372398.1 monofunctional; catalyzes the elongation of glycan strands in cell wall biosynthesis NP_372405.1 similar to protein-tyrosine phosphatase NP_372407.1 similar to transporter NP_372412.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn NP_372415.1 similar to cobyric acid synthase CobQ NP_372416.1 similar to UDP-N-acetylmuramyl tripeptide synthetase homolog NP_372417.1 similar to ferritin NP_372418.1 similar to DNA polymerase III alpha chain PolC type NP_372419.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function NP_372422.1 similar to YegS from E. coli NP_372423.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_372424.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_372425.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain NP_372430.1 PcrB-like protein; GGGP synthase; member of prenyltransferases that transfer isoprenoid groups to nonisoprenoid acceptors; functions in form GGGP from glycerol-1-phosphate (G-1-P) and geranylgeranyl pyrophosphate (GGPP); important in lipid metabolism and especially important as the ether linkages in archaea are different than those in bacteria; GGGP synthase lies at the branch point for membrane lipid biosynthesis; cytosolic; T acidophilum protein acts as a homodimer while M thermoautotrophicum protein has been reported to function as a pentamer NP_372432.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide NP_372433.1 cysteine proteinase NP_372436.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers NP_372437.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate NP_372439.1 similar to chorismate mutase/prephenate dehydratase PheA NP_372440.1 similar to sodium-dependent transporter NP_372443.1 catalyzes the hydrolysis of pyrophosphate to phosphate NP_372455.1 similar to ABC transporter, ATP-binding protein NP_372457.1 similar to ABC transporter, ATP-binding protein NP_372458.1 similar to transcription regulator GntR family NP_372460.1 similar to aspartate transaminase protein NP_372488.1 similar to scaffolding protein of NP_372528.1 similar to synergohymenotropic toxin precursor NP_372529.1 similar to leukocidin chain lukM precursor NP_372530.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. NP_372531.1 similar to Na+-transporting ATP synthase NP_372534.1 ; similar to beta-lactamase NP_372536.1 ; similar to bacteriophage terminase small subunit NP_372550.1 ; similar to transcription regulator NP_372552.1 similar to integrase in NP_372553.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth NP_372554.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring NP_372556.1 similar to SdrH NP_372559.1 Lyses erythrocytes and other mammalian cells NP_372564.1 similar to fructokinase NP_372570.1 modulates transcription in response to the NADH/NAD(+) redox state NP_372571.1 ATP-binding protein NP_372572.1 similar to DNA mismatch repair protein MutS NP_372573.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity NP_372574.1 similar to ribosomal-protein-alanine N-acetyltransfer NP_372575.1 similar to glycoprotein endopeptidase NP_372577.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis NP_372579.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, this subunit subunit is required for full activity and valine sensitivity; also known as acetolactate synthase small NP_372580.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis NP_372581.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis NP_372582.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis NP_372583.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate NP_372584.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D NP_372585.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic NP_372588.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation; induced by heat shock, salt stress, oxidative stress, glucose limitation, oxygen limitation and entry into stationary phase NP_372589.1 binds to sigma-B preventing the formation of an RNA polymerase holoenzyme NP_372595.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids NP_372599.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex NP_372600.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions NP_372601.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions NP_372604.1 Insertion sequence IS1181 NP_372605.1 similar to ATP-dependent RNA helicase NP_372607.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli NP_372608.1 similar to rod shape determining protein RodA NP_372612.1 similar to cardiolipin synthetase NP_372615.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate NP_372616.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP NP_372617.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine NP_372618.1 similar to trasncriptional activator TenA NP_372619.1 similar to SceD precursor NP_372620.1 similar to single strand DNA binding protein NP_372622.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP NP_372623.2 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_372626.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane NP_372627.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit NP_372628.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit NP_372629.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit NP_372630.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex NP_372631.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit B is part of the membrane proton channel NP_372632.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 NP_372633.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 NP_372636.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate NP_372637.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate NP_372639.1 similar to phosphatase NP_372641.1 similar to protoporphyrinogen oxidase HemK NP_372642.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 NP_372643.1 catalyzes the formation of thymidine 5'-phosphate from thymidine NP_372644.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_372645.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes NP_372646.1 similar to aldehyde dehydrogenase NP_372648.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_372649.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; induced by anaerobic conditions in Bacillus subtilis NP_372651.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer NP_372652.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling NP_372653.1 similar to spermine/spermidine acetyltransferase blt NP_372654.1 catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type II pantothenate kinases are not regulated by feedback inhibition by coenzyme A NP_372657.1 similar to amidase NP_372658.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 NP_372660.2 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway NP_372661.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate NP_372662.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate NP_372667.1 similar to mannnose-6 phospate isomelase Pmi NP_372672.1 similar to transposase for IS232 NP_372674.1 similar to transposase for IS232 NP_372675.1 similar to transposase for IS232 NP_372677.1 similar to ABC transporter ATP-binding protein NP_372678.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source NP_372681.1 similar to transcription antiterminator BglG family NP_372685.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate NP_372689.1 similar to ATP-binding Mrp-like protein NP_372690.1 similar to multidrug resistance protein NP_372694.1 similar to hemolysin III NP_372695.1 similar to UDP-N-acetylglucosamine pyrophosphorylase NP_372699.1 similar to ferrichrome ABC transporter (permease) NP_372700.1 similar to ferrichrome ABC transporter (permease) NP_372701.1 similar to ferrichrome ABC transporter NP_372704.1 similar to transporter NP_372710.1 similar to alginate lyase NP_372711.1 similar to quinone oxidoreductase NP_372713.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside NP_372716.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources NP_372717.1 catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP NP_372718.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate NP_372719.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization NP_372721.1 Modulates the activities of several enzymes which are inactive in their acetylated form NP_372724.1 similar to oxidoreductase aldo/keto reductase family NP_372725.1 similar to transcription regulator MerR family NP_372729.1 similar to MHC class II analog NP_372730.1 similar to alpha-acetolactate decarboxylase NP_372731.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase NP_372733.1 similar to RNA-directed DNA polymerase from E. coli retron NP_372737.1 similar to transposase for IS232 NP_372738.1 similar to transposase for IS232 NP_372741.1 forms a direct contact with the tRNA during translation NP_372742.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit NP_372743.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability NP_372745.1 with CbiNQ forms the ABC transporter for cobalt import; Staphylococcus has two adjacent copies of this gene NP_372746.1 with CbiNQ forms the ABC transporter for cobalt import; Staphylococcus has two adjacent copies of this gene NP_372747.1 is a component of the macrolide binding site in the peptidyl transferase center NP_372748.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme NP_372749.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 NP_372750.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA NP_372751.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif NP_372752.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 NP_372753.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP NP_372754.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_372755.1 late assembly protein NP_372756.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 NP_372757.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance NP_372758.1 binds 5S rRNA along with protein L5 and L25 NP_372759.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance NP_372760.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit NP_372761.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif NP_372762.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 NP_372763.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel NP_372764.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase NP_372765.1 primary binding protein; helps mediate assembly; involved in translation fidelity NP_372766.1 one of the stabilizing components for the large ribosomal subunit NP_372767.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e NP_372768.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation NP_372769.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center NP_372770.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA NP_372771.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation NP_372772.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel NP_372773.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA NP_372774.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin NP_372775.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex NP_372778.1 decatenates replicating daughter chromosomes NP_372785.1 similar to acriflavin resistance protein NP_372789.1 similar to transcription regulator MarR family NP_372793.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis NP_372795.1 subunit 2 NP_372798.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis NP_372804.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth NP_372806.1 similar to biotin biosynthesis protein NP_372807.1 similar to inosine-adenosine-guanosine-nucleoside hydrolase; IAG-nucleoside hydrolase NP_372808.1 similar to ferrichrome ABC transporter fhuD precursor NP_372809.1 similar to butyryl-CoA dehydrogenase NP_372811.1 similar to urea transporter NP_372812.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter NP_372813.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Staphylococcus saprophyticus plays a role in bladder invasiveness and may induce the formation of kidney and bladder stones due to the alkalization of urine NP_372814.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits NP_372815.1 involved in the assembly of the urease metallocenter; possible nickel donor NP_372822.1 similar to transcription regulator NP_372825.1 similar to Na+/H+ antiporter NP_372826.1 similar to D-octopine dehydrogenase NP_372828.1 similar to secretory antigen precursor SsaA NP_372829.1 Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor NP_372830.1 similar to monooxygenase NP_372831.1 similar to autolysin E NP_372834.1 similar to lyt divergon expression attenuator LytR NP_372835.1 similar to suppressor protein suhB NP_372837.1 similar to protein of pXO2-46 NP_372839.1 similar to transcription regulator RpiR family NP_372840.1 similar to transport protein NP_372844.1 similar to phosphoglycolate phosphatase NP_372845.1 similar to sodium-dependent transporter NP_372848.1 similar to transcriptional regulator NP_372850.1 similar to Na+/H+ antiporter NP_372852.1 similar to dehydrogenase NP_372853.1 similar to amino acid amidohydrolase NP_372854.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway NP_372855.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism NP_372856.1 similar to transcription regulator LysR family NP_372857.1 catalyzes resistance to fosfomycin by the addition of a thiol cofactor NP_372858.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate NP_372860.1 catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway NP_372862.1 similar to aldose 1-epimerase NP_372865.1 similar to ABC transporter ATP-binding protein NP_372868.1 similar to DNA-3-methyladenine glycosidase NP_372869.1 similar to sodium/glutamate symporter NP_372870.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate NP_372871.1 similar to divalent cation transport NP_372874.1 similar to esterase NP_372876.1 similar to multidrug resistance protein NP_372878.1 similar to transcriptional regulator TetR/AcrR family NP_372882.1 similar to membrane protein NP_372883.1 similar to ABC transporter ATP-binding protein NP_372885.1 similar to two component response regulator NP_372886.1 similar to two component histidine kinase sensor NP_372889.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate NP_372892.1 similar to TpgX protein NP_372893.1 similar to transcription repressor of sporulation, septation and degradation paiA NP_372895.1 similar to attachment to host cells and virulence NP_372896.1 similar to thioredoxin reductase NP_372898.1 similar to phage infection protein precursor NP_372899.1 similar to transcriptional regulator TetR-family NP_372900.1 similar to cationic transporter NP_372902.2 methyltransferase NP_372903.1 Insertion sequence IS1181 NP_372905.1 similar to transcription regulatory protein NP_372906.1 similar to general stress protein 26 NP_372910.1 similar to transcriptional regulator NP_372911.1 similar to small heat shock protein NP_372914.1 similar to transcriptional regulator NP_372915.1 similar to response regulators of two-component regulatory system NP_372916.1 similar to two component sensor histidine kinase NP_372919.1 similar to nitrate reductase delta chain NP_372925.1 similar to NirR NP_372927.1 similar to NirC NP_372930.1 similar to Zn-binding lipoprotein adcA NP_372936.1 similar to ABC transporter ATP binding subunit NP_372937.1 similar to ABC transporter permease protein NP_372938.1 similar to ABC transporter periplasmic amino acid-binding protein NP_372939.1 similar to multidrug resistance protein NP_372940.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate NP_372946.1 similar to BioX protein NP_372947.1 catalyzes the formation of pimeloyl-CoA from pimelate and coenzyme A NP_372948.1 similar to 8-amino-7-oxononanoate synthase NP_372949.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine NP_372952.1 similar to ABC transporter ATP-binding protein NP_372953.1 similar to lipoprotein inner membrane ABC-transporter NP_372958.1 similar to bicyclomycin resistance protein TcaB NP_372959.1 similar to transcriptional activator NP_372962.1 permease NP_372963.1 similar to NA(+)/H(+) exchanger NP_372965.1 similar to beta-lactamase NP_372966.1 similar to glucose epimerase NP_372967.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis NP_372968.1 similar to integral membrane efflux protein NP_372969.1 membrane protein NP_372970.1 osmoprotectant NP_372971.1 membrane protein NP_372972.1 ATP-binding; SAV2448 NP_372974.1 similar to amino acid transporter NP_372975.1 similar to para-nitrobenzyl esterase chain A NP_372976.1 similar to chloramphenicol resistance protein NP_372978.1 similar to ABC transporter ATP-binding protein NP_372979.1 similar to endo-1,4-beta-glucanase NP_372983.1 similar to glutamate synthase, ferredoxin NP_372986.1 similar to antibiotic resistance protein NP_372994.1 similar to diaminopimelate epimerase NP_372996.1 similar to glucose 1-dehydrogenase NP_372997.1 similar to efflux pump NP_373002.1 similar to oxidoreductase NP_373014.1 similar to mutator protein MutT NP_373015.1 similar to phosphomannomutase NP_373020.2 similar to accumulation-associated protein NP_373021.1 similar to accumulation-associated protein NP_373025.1 Insertion sequence IS1181 NP_373032.1 similar to transcriptional regulator, MerR family NP_373033.1 similar to GTP-pyrophosphokinase NP_373036.1 similar to glucarate transporter NP_373037.1 similar to alkaline phosphatase NP_373038.1 similar to ABC transporter NP_373039.1 similar to membrane spanning protein NP_373043.1 similar to ABC transporter NP_373044.1 similar to transcription regulator MarR family NP_373047.1 similar to NAD(P)H-flavin oxidoreductase NP_373048.1 catalyzes the formation of pyruvate from lactate NP_373050.1 similar to ABC transporter, ATP-binding protein NP_373053.1 similar to N-acetyltransferase NP_373054.1 similar to L-serine dehydratase NP_373055.1 similar to beta-subunit of L-serine dehydratas NP_373056.1 similar to regulatory protein PfoR NP_373060.1 similar to thioredoxin NP_373063.1 catalyzes the formation of acetyl phosphate from pyruvate NP_373066.1 similar to transcription regulator NP_373068.1 similar to secretory antigen precursor SsaA NP_373076.1 similar to antibiotic transport-associated protein NP_373077.1 similar to transcriptional regulator tetR-family NP_373078.1 catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate NP_373079.1 similar to O-acetyltransferase NP_373082.1 similar to mercuric ion-binding protein NP_373083.1 catalyzes the formation of pyruvate from lactate NP_373084.1 similar to aspartate aminotransferase NP_373088.1 similar to phytoene dehydrogenase NP_373090.1 similar to secretory antigen precursor SsaA NP_373091.1 similar to acyltransferase NP_373094.1 similar to regulatory protein (pfoS/R) NP_373095.1 similar to transcriptional regulator (TetR/AcrR family) NP_373102.1 similar to transcription regulator acrR NP_373103.1 similar to short chain oxidoreductase NP_373106.1 similar to cobalamin synthesis related protein CobW NP_373107.1 similar to ferrous iron transporter protein B NP_373113.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors NP_373117.1 similar to transcriptional regulator tetR-family NP_373120.1 similar to metalloproteinase Mpr precursor NP_373121.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) NP_373122.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine NP_373123.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate NP_373124.1 catalyzes the formation of 2-dehydropantoate from (R)-pantoate NP_373125.1 similar to alpha-acetolactate decarboxylase NP_373127.1 similar to amino acid transporter NP_373128.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate NP_373130.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis NP_373131.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate NP_373136.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine NP_373140.1 similar to anaerobic ribonucleotide reductase activator protein NP_373141.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates NP_373142.1 similar to magnesium citrate secondary transporter NP_373143.1 catalyzes the formation of siroheme from precorrin-2 NP_373144.1 NADPH NP_373145.1 similar to glutathione peroxidase NP_373146.1 similar to ABC transporter, permease NP_373147.1 similar to ABC transporter, ATP-binding protein NP_373148.1 similar to two-component sensor histidine kinase NP_373149.1 similar to two-component response regulator NP_373152.1 similar to transcriptional regulator NP_373153.1 similar to tributyrin esterase NP_373155.1 similar to transcription regulator Crp/Fnr family protein NP_373156.2 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP NP_373158.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway NP_373159.1 catalyzes the degradation of arginine to citruline and ammonia NP_373160.1 similar to arginine repressor NP_373164.1 similar to transcription antiterminator BglG family NP_373167.1 similar to phage infection protein NP_373168.1 similar to autolysin precursor NP_373169.1 similar to N-carbamoylsarcosine amidohydrolase NP_373172.1 similar to lipopolysaccharide biosynthesis protein NP_373173.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins NP_373177.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_373178.1 similar to streptococcal hemagglutinin protein NP_373184.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; a fusion protein of this enzyme with MsrB provides protection against oxidative stress in Neisseria gonorrhoeae NP_373186.1 capC NP_373187.1 capB NP_373188.1 capA NP_373190.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein NP_373196.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis NP_373197.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase NP_373198.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-hosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide NP_373199.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide NP_373200.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis NP_373201.1 similar to histidinol-phosphate transaminase NP_373202.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer NP_373203.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ NP_373204.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine NP_373208.1 similar to cation ABC transporter, ATP-binding protein NP_373214.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline NP_373220.1 similar to rarD protein NP_373222.1 similar to high-affinity nickel-transport protein NP_373223.1 similar to N-hydroxyarylamine O-acetyltransferase NP_373225.1 similar to ABC transporter NP_373226.1 similar to ABC transporter, permease NP_373229.1 similar to hypothetical protein NP_373233.1 similar to DNA-binding protein Spo0J-like homolog NP_373234.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA NP_373235.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs NP_373236.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE NP_373237.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates NP_373238.1 in Escherichia coli transcription of this gene is enhanced by polyamines NP_115292.1 similar to nicking enzyme NP_115303.1 Staphylococcus aureus insertion sequence IS257-1 NP_115312.1 Staphylococcus aureus insertion sequence IS257-3 NP_115313.1 Staphylococcus aureus insertion sequence IS257-2 NP_115314.1 insertion sequence element IS256 in transposon Tn4001 NP_115315.1 2''-aminoglycoside phosphotransferase; 6'-aminoglycoside N-acetyltransferase NP_115317.1 insertion sequence element IS256 in transposon Tn4001 NP_115318.1 Staphylococcus aureus insertion sequence IS257-1