-- dump date 20140620_074430 -- class Genbank::misc_feature -- table misc_feature_note -- id note 158878000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 158878000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 158878000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878000004 Walker A motif; other site 158878000005 ATP binding site [chemical binding]; other site 158878000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 158878000007 Walker B motif; other site 158878000008 arginine finger; other site 158878000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 158878000010 DnaA box-binding interface [nucleotide binding]; other site 158878000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 158878000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 158878000013 putative DNA binding surface [nucleotide binding]; other site 158878000014 dimer interface [polypeptide binding]; other site 158878000015 beta-clamp/clamp loader binding surface; other site 158878000016 beta-clamp/translesion DNA polymerase binding surface; other site 158878000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 158878000018 recF protein; Region: recf; TIGR00611 158878000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 158878000020 Walker A/P-loop; other site 158878000021 ATP binding site [chemical binding]; other site 158878000022 Q-loop/lid; other site 158878000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158878000024 ABC transporter signature motif; other site 158878000025 Walker B; other site 158878000026 D-loop; other site 158878000027 H-loop/switch region; other site 158878000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 158878000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878000030 Mg2+ binding site [ion binding]; other site 158878000031 G-X-G motif; other site 158878000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 158878000033 anchoring element; other site 158878000034 dimer interface [polypeptide binding]; other site 158878000035 ATP binding site [chemical binding]; other site 158878000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 158878000037 active site 158878000038 putative metal-binding site [ion binding]; other site 158878000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 158878000040 DNA gyrase subunit A; Validated; Region: PRK05560 158878000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 158878000042 CAP-like domain; other site 158878000043 active site 158878000044 primary dimer interface [polypeptide binding]; other site 158878000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158878000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158878000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158878000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158878000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158878000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158878000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 158878000052 putative substrate binding site [chemical binding]; other site 158878000053 putative ATP binding site [chemical binding]; other site 158878000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 158878000055 active sites [active] 158878000056 tetramer interface [polypeptide binding]; other site 158878000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 158878000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 158878000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 158878000060 dimer interface [polypeptide binding]; other site 158878000061 active site 158878000062 motif 1; other site 158878000063 motif 2; other site 158878000064 motif 3; other site 158878000065 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 158878000066 Predicted membrane protein [Function unknown]; Region: COG4392 158878000067 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 158878000068 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 158878000069 Predicted membrane protein [Function unknown]; Region: COG4241 158878000070 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 158878000071 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 158878000072 DHH family; Region: DHH; pfam01368 158878000073 DHHA1 domain; Region: DHHA1; pfam02272 158878000074 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 158878000075 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 158878000076 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 158878000077 replicative DNA helicase; Region: DnaB; TIGR00665 158878000078 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 158878000079 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 158878000080 Walker A motif; other site 158878000081 ATP binding site [chemical binding]; other site 158878000082 Walker B motif; other site 158878000083 DNA binding loops [nucleotide binding] 158878000084 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 158878000085 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 158878000086 GDP-binding site [chemical binding]; other site 158878000087 ACT binding site; other site 158878000088 IMP binding site; other site 158878000089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158878000090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878000091 active site 158878000092 phosphorylation site [posttranslational modification] 158878000093 intermolecular recognition site; other site 158878000094 dimerization interface [polypeptide binding]; other site 158878000095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158878000096 DNA binding site [nucleotide binding] 158878000097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 158878000098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158878000099 dimerization interface [polypeptide binding]; other site 158878000100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158878000101 putative active site [active] 158878000102 heme pocket [chemical binding]; other site 158878000103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158878000104 dimer interface [polypeptide binding]; other site 158878000105 phosphorylation site [posttranslational modification] 158878000106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878000107 ATP binding site [chemical binding]; other site 158878000108 Mg2+ binding site [ion binding]; other site 158878000109 G-X-G motif; other site 158878000110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 158878000111 YycH protein; Region: YycH; pfam07435 158878000112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 158878000113 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 158878000114 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 158878000115 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 158878000116 putative active site [active] 158878000117 putative metal binding site [ion binding]; other site 158878000118 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 158878000119 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 158878000120 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 158878000121 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 158878000122 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 158878000123 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 158878000124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 158878000125 Integrase core domain; Region: rve; pfam00665 158878000126 Replication protein; Region: Rep_1; cl02412 158878000127 Plasmid rolling circle replication initiator protein and truncated derivatives [DNA replication, recombination, and repair]; Region: COG5655 158878000128 similar to hypothetical protein 158878000129 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 158878000130 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 158878000131 dimer interface [polypeptide binding]; other site 158878000132 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158878000133 ligand binding site [chemical binding]; other site 158878000134 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cd05397 158878000135 metal binding triad [ion binding]; metal-binding site 158878000136 KNTase C-terminal domain; Region: KNTase_C; pfam07827 158878000137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 158878000138 Integrase core domain; Region: rve; pfam00665 158878000139 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 158878000140 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 158878000141 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 158878000142 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 158878000143 putative active site [active] 158878000144 catalytic site [active] 158878000145 putative metal binding site [ion binding]; other site 158878000146 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 158878000147 putative active site [active] 158878000148 putative catalytic site [active] 158878000149 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 158878000150 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 158878000151 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 158878000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 158878000153 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 158878000154 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 158878000155 Predicted transcriptional regulator [Transcription]; Region: COG3682 158878000156 MarR family; Region: MarR_2; pfam12802 158878000157 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158878000158 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158878000159 nucleotide binding site [chemical binding]; other site 158878000160 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 158878000161 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 158878000162 active site residue [active] 158878000163 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 158878000164 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 158878000165 active site residue [active] 158878000166 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 158878000167 CPxP motif; other site 158878000168 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 158878000169 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 158878000170 putative homodimer interface [polypeptide binding]; other site 158878000171 putative homotetramer interface [polypeptide binding]; other site 158878000172 putative metal binding site [ion binding]; other site 158878000173 putative homodimer-homodimer interface [polypeptide binding]; other site 158878000174 putative allosteric switch controlling residues; other site 158878000175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878000176 S-adenosylmethionine binding site [chemical binding]; other site 158878000177 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 158878000178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878000179 S-adenosylmethionine binding site [chemical binding]; other site 158878000180 aminoglycoside resistance protein; Provisional; Region: PRK13746 158878000181 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 158878000182 active site 158878000183 NTP binding site [chemical binding]; other site 158878000184 metal binding triad [ion binding]; metal-binding site 158878000185 antibiotic binding site [chemical binding]; other site 158878000186 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 158878000187 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 158878000188 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 158878000189 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 158878000190 Int/Topo IB signature motif; other site 158878000191 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 158878000192 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 158878000193 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 158878000194 Int/Topo IB signature motif; other site 158878000195 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 158878000196 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 158878000197 MPN+ (JAMM) motif; other site 158878000198 Zinc-binding site [ion binding]; other site 158878000199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4333 158878000200 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 158878000201 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 158878000202 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 158878000203 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 158878000204 catalytic residues [active] 158878000205 catalytic nucleophile [active] 158878000206 Presynaptic Site I dimer interface [polypeptide binding]; other site 158878000207 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 158878000208 Synaptic Flat tetramer interface [polypeptide binding]; other site 158878000209 Synaptic Site I dimer interface [polypeptide binding]; other site 158878000210 DNA binding site [nucleotide binding] 158878000211 Recombinase; Region: Recombinase; pfam07508 158878000212 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 158878000213 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 158878000214 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 158878000215 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 158878000216 catalytic residues [active] 158878000217 catalytic nucleophile [active] 158878000218 Recombinase; Region: Recombinase; pfam07508 158878000219 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 158878000220 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 158878000221 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 158878000222 Integrase core domain; Region: rve; pfam00665 158878000223 Integrase core domain; Region: rve_3; cl15866 158878000224 HTH-like domain; Region: HTH_21; pfam13276 158878000225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 158878000226 Homeodomain-like domain; Region: HTH_23; cl17451 158878000227 Predicted membrane protein [Function unknown]; Region: COG1288 158878000228 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158878000229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878000230 active site 158878000231 phosphorylation site [posttranslational modification] 158878000232 intermolecular recognition site; other site 158878000233 dimerization interface [polypeptide binding]; other site 158878000234 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158878000235 DNA binding site [nucleotide binding] 158878000236 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 158878000237 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 158878000238 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 158878000239 Ligand Binding Site [chemical binding]; other site 158878000240 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 158878000241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158878000242 dimer interface [polypeptide binding]; other site 158878000243 phosphorylation site [posttranslational modification] 158878000244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878000245 ATP binding site [chemical binding]; other site 158878000246 Mg2+ binding site [ion binding]; other site 158878000247 G-X-G motif; other site 158878000248 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 158878000249 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 158878000250 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 158878000251 Soluble P-type ATPase [General function prediction only]; Region: COG4087 158878000252 potassium-transporting ATPase subunit C; Provisional; Region: PRK14000 158878000253 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 158878000254 Protein kinase domain; Region: Pkinase; pfam00069 158878000255 Catalytic domain of Protein Kinases; Region: PKc; cd00180 158878000256 active site 158878000257 ATP binding site [chemical binding]; other site 158878000258 substrate binding site [chemical binding]; other site 158878000259 activation loop (A-loop); other site 158878000260 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 158878000261 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 158878000262 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 158878000263 phosphate binding site [ion binding]; other site 158878000264 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 158878000265 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 158878000266 putative homodimer interface [polypeptide binding]; other site 158878000267 putative homotetramer interface [polypeptide binding]; other site 158878000268 putative metal binding site [ion binding]; other site 158878000269 putative homodimer-homodimer interface [polypeptide binding]; other site 158878000270 putative allosteric switch controlling residues; other site 158878000271 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 158878000272 active site residue [active] 158878000273 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 158878000274 CPxP motif; other site 158878000275 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 158878000276 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 158878000277 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 158878000278 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 158878000279 active site residue [active] 158878000280 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 158878000281 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 158878000282 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 158878000283 FMN binding site [chemical binding]; other site 158878000284 active site 158878000285 catalytic residues [active] 158878000286 substrate binding site [chemical binding]; other site 158878000287 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 158878000288 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 158878000289 Part of AAA domain; Region: AAA_19; pfam13245 158878000290 AAA domain; Region: AAA_12; pfam13087 158878000291 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 158878000292 active site 158878000293 catalytic site [active] 158878000294 putative metal binding site [ion binding]; other site 158878000295 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878000296 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878000297 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878000298 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878000299 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878000300 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 158878000301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158878000302 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 158878000303 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 158878000304 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 158878000305 metal binding site [ion binding]; metal-binding site 158878000306 dimer interface [polypeptide binding]; other site 158878000307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878000308 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158878000309 putative substrate translocation pore; other site 158878000310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878000311 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 158878000312 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 158878000313 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 158878000314 PhoU domain; Region: PhoU; pfam01895 158878000315 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 158878000316 EamA-like transporter family; Region: EamA; pfam00892 158878000317 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 158878000318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158878000319 DNA-binding site [nucleotide binding]; DNA binding site 158878000320 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158878000321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878000322 homodimer interface [polypeptide binding]; other site 158878000323 catalytic residue [active] 158878000324 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 158878000325 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 158878000326 L-lactate permease; Region: Lactate_perm; cl00701 158878000327 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 158878000328 B domain; Region: B; pfam02216 158878000329 B domain; Region: B; pfam02216 158878000330 B domain; Region: B; pfam02216 158878000331 B domain; Region: B; pfam02216 158878000332 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 158878000333 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 158878000334 Transcriptional regulators [Transcription]; Region: MarR; COG1846 158878000335 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 158878000336 Transcriptional regulators [Transcription]; Region: MarR; COG1846 158878000337 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 158878000338 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158878000339 ABC-ATPase subunit interface; other site 158878000340 dimer interface [polypeptide binding]; other site 158878000341 putative PBP binding regions; other site 158878000342 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 158878000343 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158878000344 ABC-ATPase subunit interface; other site 158878000345 dimer interface [polypeptide binding]; other site 158878000346 putative PBP binding regions; other site 158878000347 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 158878000348 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 158878000349 siderophore binding site; other site 158878000350 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 158878000351 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 158878000352 dimer interface [polypeptide binding]; other site 158878000353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878000354 catalytic residue [active] 158878000355 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 158878000356 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 158878000357 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 158878000358 IucA / IucC family; Region: IucA_IucC; pfam04183 158878000359 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 158878000360 drug efflux system protein MdtG; Provisional; Region: PRK09874 158878000361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878000362 putative substrate translocation pore; other site 158878000363 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 158878000364 IucA / IucC family; Region: IucA_IucC; pfam04183 158878000365 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 158878000366 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 158878000367 IucA / IucC family; Region: IucA_IucC; pfam04183 158878000368 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 158878000369 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 158878000370 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 158878000371 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 158878000372 dimer interface [polypeptide binding]; other site 158878000373 active site 158878000374 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158878000375 catalytic residues [active] 158878000376 substrate binding site [chemical binding]; other site 158878000377 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 158878000378 ParB-like nuclease domain; Region: ParBc; pfam02195 158878000379 acetoin reductase; Validated; Region: PRK08643 158878000380 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 158878000381 NAD binding site [chemical binding]; other site 158878000382 homotetramer interface [polypeptide binding]; other site 158878000383 homodimer interface [polypeptide binding]; other site 158878000384 active site 158878000385 substrate binding site [chemical binding]; other site 158878000386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158878000387 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 158878000388 NAD(P) binding site [chemical binding]; other site 158878000389 active site 158878000390 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 158878000391 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 158878000392 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158878000393 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 158878000394 putative ADP-binding pocket [chemical binding]; other site 158878000395 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 158878000396 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 158878000397 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 158878000398 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 158878000399 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 158878000400 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 158878000401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158878000402 DNA-binding site [nucleotide binding]; DNA binding site 158878000403 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 158878000404 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 158878000405 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158878000406 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 158878000407 intersubunit interface [polypeptide binding]; other site 158878000408 active site 158878000409 catalytic residue [active] 158878000410 phosphopentomutase; Provisional; Region: PRK05362 158878000411 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 158878000412 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 158878000413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878000414 dimer interface [polypeptide binding]; other site 158878000415 conserved gate region; other site 158878000416 putative PBP binding loops; other site 158878000417 ABC-ATPase subunit interface; other site 158878000418 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 158878000419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878000420 dimer interface [polypeptide binding]; other site 158878000421 conserved gate region; other site 158878000422 ABC-ATPase subunit interface; other site 158878000423 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 158878000424 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 158878000425 Walker A/P-loop; other site 158878000426 ATP binding site [chemical binding]; other site 158878000427 Q-loop/lid; other site 158878000428 ABC transporter signature motif; other site 158878000429 Walker B; other site 158878000430 D-loop; other site 158878000431 H-loop/switch region; other site 158878000432 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 158878000433 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 158878000434 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 158878000435 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 158878000436 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 158878000437 active site 158878000438 metal binding site [ion binding]; metal-binding site 158878000439 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 158878000440 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158878000441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878000442 non-specific DNA binding site [nucleotide binding]; other site 158878000443 salt bridge; other site 158878000444 sequence-specific DNA binding site [nucleotide binding]; other site 158878000445 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 158878000446 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 158878000447 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 158878000448 putative catalytic cysteine [active] 158878000449 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 158878000450 putative active site [active] 158878000451 metal binding site [ion binding]; metal-binding site 158878000452 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 158878000453 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 158878000454 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 158878000455 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 158878000456 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 158878000457 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 158878000458 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 158878000459 NAD(P) binding site [chemical binding]; other site 158878000460 homodimer interface [polypeptide binding]; other site 158878000461 substrate binding site [chemical binding]; other site 158878000462 active site 158878000463 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 158878000464 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 158878000465 NAD(P) binding site [chemical binding]; other site 158878000466 homodimer interface [polypeptide binding]; other site 158878000467 substrate binding site [chemical binding]; other site 158878000468 active site 158878000469 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 158878000470 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 158878000471 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 158878000472 putative NAD(P) binding site [chemical binding]; other site 158878000473 active site 158878000474 putative substrate binding site [chemical binding]; other site 158878000475 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 158878000476 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 158878000477 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 158878000478 active site 158878000479 homodimer interface [polypeptide binding]; other site 158878000480 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 158878000481 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 158878000482 trimer interface [polypeptide binding]; other site 158878000483 active site 158878000484 substrate binding site [chemical binding]; other site 158878000485 CoA binding site [chemical binding]; other site 158878000486 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158878000487 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 158878000488 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 158878000489 O-Antigen ligase; Region: Wzy_C; pfam04932 158878000490 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158878000491 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 158878000492 Bacterial sugar transferase; Region: Bac_transf; pfam02397 158878000493 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 158878000494 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 158878000495 putative NAD(P) binding site [chemical binding]; other site 158878000496 active site 158878000497 putative substrate binding site [chemical binding]; other site 158878000498 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 158878000499 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 158878000500 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 158878000501 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 158878000502 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 158878000503 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 158878000504 active site 158878000505 homodimer interface [polypeptide binding]; other site 158878000506 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 158878000507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 158878000508 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 158878000509 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 158878000510 NAD(P) binding site [chemical binding]; other site 158878000511 catalytic residues [active] 158878000512 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 158878000513 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 158878000514 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 158878000515 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 158878000516 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 158878000517 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 158878000518 Walker A/P-loop; other site 158878000519 ATP binding site [chemical binding]; other site 158878000520 Q-loop/lid; other site 158878000521 ABC transporter signature motif; other site 158878000522 Walker B; other site 158878000523 D-loop; other site 158878000524 H-loop/switch region; other site 158878000525 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 158878000526 NMT1-like family; Region: NMT1_2; pfam13379 158878000527 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 158878000528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 158878000529 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 158878000530 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 158878000531 active site 158878000532 Uncharacterized conserved protein [Function unknown]; Region: COG5609 158878000533 formate dehydrogenase; Provisional; Region: PRK07574 158878000534 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 158878000535 dimerization interface [polypeptide binding]; other site 158878000536 ligand binding site [chemical binding]; other site 158878000537 NAD binding site [chemical binding]; other site 158878000538 catalytic site [active] 158878000539 putative transporter; Provisional; Region: PRK10054 158878000540 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 158878000541 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 158878000542 acyl-activating enzyme (AAE) consensus motif; other site 158878000543 AMP binding site [chemical binding]; other site 158878000544 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 158878000545 Condensation domain; Region: Condensation; pfam00668 158878000546 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 158878000547 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 158878000548 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 158878000549 acyl-activating enzyme (AAE) consensus motif; other site 158878000550 AMP binding site [chemical binding]; other site 158878000551 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 158878000552 thioester reductase domain; Region: Thioester-redct; TIGR01746 158878000553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158878000554 NAD(P) binding site [chemical binding]; other site 158878000555 active site 158878000556 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 158878000557 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 158878000558 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 158878000559 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 158878000560 nucleotide binding site [chemical binding]; other site 158878000561 N-acetyl-L-glutamate binding site [chemical binding]; other site 158878000562 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 158878000563 heterotetramer interface [polypeptide binding]; other site 158878000564 active site pocket [active] 158878000565 cleavage site 158878000566 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 158878000567 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 158878000568 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 158878000569 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 158878000570 inhibitor-cofactor binding pocket; inhibition site 158878000571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878000572 catalytic residue [active] 158878000573 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 158878000574 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 158878000575 Isochorismatase family; Region: Isochorismatase; pfam00857 158878000576 catalytic triad [active] 158878000577 conserved cis-peptide bond; other site 158878000578 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 158878000579 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 158878000580 dimer interface [polypeptide binding]; other site 158878000581 PYR/PP interface [polypeptide binding]; other site 158878000582 TPP binding site [chemical binding]; other site 158878000583 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 158878000584 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 158878000585 TPP-binding site [chemical binding]; other site 158878000586 dimer interface [polypeptide binding]; other site 158878000587 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 158878000588 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 158878000589 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 158878000590 active site turn [active] 158878000591 phosphorylation site [posttranslational modification] 158878000592 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 158878000593 HPr interaction site; other site 158878000594 glycerol kinase (GK) interaction site [polypeptide binding]; other site 158878000595 active site 158878000596 phosphorylation site [posttranslational modification] 158878000597 Uncharacterized conserved protein [Function unknown]; Region: COG3589 158878000598 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 158878000599 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 158878000600 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 158878000601 putative active site [active] 158878000602 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 158878000603 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 158878000604 active site turn [active] 158878000605 phosphorylation site [posttranslational modification] 158878000606 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 158878000607 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158878000608 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 158878000609 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 158878000610 putative active site [active] 158878000611 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 158878000612 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 158878000613 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158878000614 ATP binding site [chemical binding]; other site 158878000615 putative Mg++ binding site [ion binding]; other site 158878000616 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 158878000617 HlyD family secretion protein; Region: HlyD_3; pfam13437 158878000618 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158878000619 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158878000620 Walker A/P-loop; other site 158878000621 ATP binding site [chemical binding]; other site 158878000622 Q-loop/lid; other site 158878000623 ABC transporter signature motif; other site 158878000624 Walker B; other site 158878000625 D-loop; other site 158878000626 H-loop/switch region; other site 158878000627 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 158878000628 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 158878000629 FtsX-like permease family; Region: FtsX; pfam02687 158878000630 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 158878000631 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 158878000632 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158878000633 Walker A/P-loop; other site 158878000634 ATP binding site [chemical binding]; other site 158878000635 Q-loop/lid; other site 158878000636 ABC transporter signature motif; other site 158878000637 Walker B; other site 158878000638 D-loop; other site 158878000639 H-loop/switch region; other site 158878000640 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 158878000641 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158878000642 Walker A/P-loop; other site 158878000643 ATP binding site [chemical binding]; other site 158878000644 Q-loop/lid; other site 158878000645 ABC transporter signature motif; other site 158878000646 Walker B; other site 158878000647 D-loop; other site 158878000648 H-loop/switch region; other site 158878000649 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 158878000650 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158878000651 Walker A/P-loop; other site 158878000652 ATP binding site [chemical binding]; other site 158878000653 Q-loop/lid; other site 158878000654 ABC transporter signature motif; other site 158878000655 Walker B; other site 158878000656 D-loop; other site 158878000657 H-loop/switch region; other site 158878000658 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 158878000659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878000660 dimer interface [polypeptide binding]; other site 158878000661 conserved gate region; other site 158878000662 putative PBP binding loops; other site 158878000663 ABC-ATPase subunit interface; other site 158878000664 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 158878000665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878000666 dimer interface [polypeptide binding]; other site 158878000667 conserved gate region; other site 158878000668 ABC-ATPase subunit interface; other site 158878000669 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 158878000670 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 158878000671 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 158878000672 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 158878000673 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 158878000674 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742 158878000675 azoreductase; Reviewed; Region: PRK00170 158878000676 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 158878000677 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 158878000678 Peptidase family M23; Region: Peptidase_M23; pfam01551 158878000679 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 158878000680 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 158878000681 Walker A/P-loop; other site 158878000682 ATP binding site [chemical binding]; other site 158878000683 Q-loop/lid; other site 158878000684 ABC transporter signature motif; other site 158878000685 Walker B; other site 158878000686 D-loop; other site 158878000687 H-loop/switch region; other site 158878000688 TOBE domain; Region: TOBE; pfam03459 158878000689 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 158878000690 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158878000691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878000692 dimer interface [polypeptide binding]; other site 158878000693 conserved gate region; other site 158878000694 ABC-ATPase subunit interface; other site 158878000695 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158878000696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878000697 dimer interface [polypeptide binding]; other site 158878000698 conserved gate region; other site 158878000699 putative PBP binding loops; other site 158878000700 ABC-ATPase subunit interface; other site 158878000701 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158878000702 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158878000703 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158878000704 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158878000705 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158878000706 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158878000707 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158878000708 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 158878000709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 158878000710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878000711 putative substrate translocation pore; other site 158878000712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878000713 Response regulator receiver domain; Region: Response_reg; pfam00072 158878000714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878000715 active site 158878000716 phosphorylation site [posttranslational modification] 158878000717 intermolecular recognition site; other site 158878000718 dimerization interface [polypeptide binding]; other site 158878000719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158878000720 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158878000721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158878000722 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 158878000723 Histidine kinase; Region: His_kinase; pfam06580 158878000724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878000725 ATP binding site [chemical binding]; other site 158878000726 Mg2+ binding site [ion binding]; other site 158878000727 G-X-G motif; other site 158878000728 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 158878000729 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158878000730 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 158878000731 Pyruvate formate lyase 1; Region: PFL1; cd01678 158878000732 coenzyme A binding site [chemical binding]; other site 158878000733 active site 158878000734 catalytic residues [active] 158878000735 glycine loop; other site 158878000736 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 158878000737 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158878000738 FeS/SAM binding site; other site 158878000739 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 158878000740 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 158878000741 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 158878000742 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 158878000743 putative active site [active] 158878000744 catalytic site [active] 158878000745 putative metal binding site [ion binding]; other site 158878000746 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 158878000747 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 158878000748 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 158878000749 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 158878000750 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 158878000751 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 158878000752 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 158878000753 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 158878000754 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 158878000755 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 158878000756 dimer interface [polypeptide binding]; other site 158878000757 active site 158878000758 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 158878000759 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 158878000760 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 158878000761 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 158878000762 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 158878000763 substrate binding site [chemical binding]; other site 158878000764 oxyanion hole (OAH) forming residues; other site 158878000765 trimer interface [polypeptide binding]; other site 158878000766 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 158878000767 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 158878000768 active site 158878000769 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 158878000770 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 158878000771 acyl-activating enzyme (AAE) consensus motif; other site 158878000772 AMP binding site [chemical binding]; other site 158878000773 active site 158878000774 CoA binding site [chemical binding]; other site 158878000775 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 158878000776 Coenzyme A transferase; Region: CoA_trans; smart00882 158878000777 Coenzyme A transferase; Region: CoA_trans; cl17247 158878000778 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 158878000779 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 158878000780 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 158878000781 Uncharacterized conserved protein [Function unknown]; Region: COG3189 158878000782 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 158878000783 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 158878000784 heme-binding site [chemical binding]; other site 158878000785 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 158878000786 FAD binding pocket [chemical binding]; other site 158878000787 FAD binding motif [chemical binding]; other site 158878000788 phosphate binding motif [ion binding]; other site 158878000789 beta-alpha-beta structure motif; other site 158878000790 NAD binding pocket [chemical binding]; other site 158878000791 Heme binding pocket [chemical binding]; other site 158878000792 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 158878000793 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 158878000794 tetramer (dimer of dimers) interface [polypeptide binding]; other site 158878000795 NAD binding site [chemical binding]; other site 158878000796 dimer interface [polypeptide binding]; other site 158878000797 substrate binding site [chemical binding]; other site 158878000798 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 158878000799 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 158878000800 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 158878000801 active site turn [active] 158878000802 phosphorylation site [posttranslational modification] 158878000803 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 158878000804 active site 158878000805 tetramer interface [polypeptide binding]; other site 158878000806 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 158878000807 Mga helix-turn-helix domain; Region: Mga; pfam05043 158878000808 PRD domain; Region: PRD; pfam00874 158878000809 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 158878000810 active site 158878000811 P-loop; other site 158878000812 phosphorylation site [posttranslational modification] 158878000813 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158878000814 active site 158878000815 phosphorylation site [posttranslational modification] 158878000816 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158878000817 active site 158878000818 phosphorylation site [posttranslational modification] 158878000819 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 158878000820 active site 158878000821 P-loop; other site 158878000822 phosphorylation site [posttranslational modification] 158878000823 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 158878000824 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 158878000825 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158878000826 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 158878000827 putative NAD(P) binding site [chemical binding]; other site 158878000828 catalytic Zn binding site [ion binding]; other site 158878000829 structural Zn binding site [ion binding]; other site 158878000830 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158878000831 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 158878000832 putative NAD(P) binding site [chemical binding]; other site 158878000833 catalytic Zn binding site [ion binding]; other site 158878000834 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 158878000835 substrate binding site; other site 158878000836 dimer interface; other site 158878000837 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 158878000838 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158878000839 putative NAD(P) binding site [chemical binding]; other site 158878000840 putative catalytic Zn binding site [ion binding]; other site 158878000841 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 158878000842 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 158878000843 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 158878000844 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 158878000845 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 158878000846 substrate binding site; other site 158878000847 dimer interface; other site 158878000848 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 158878000849 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158878000850 putative NAD(P) binding site [chemical binding]; other site 158878000851 putative catalytic Zn binding site [ion binding]; other site 158878000852 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 158878000853 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 158878000854 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 158878000855 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 158878000856 active site 158878000857 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 158878000858 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 158878000859 Hemerythrin-like domain; Region: Hr-like; cd12108 158878000860 Fe binding site [ion binding]; other site 158878000861 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 158878000862 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 158878000863 Histidine kinase; Region: His_kinase; pfam06580 158878000864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878000865 Mg2+ binding site [ion binding]; other site 158878000866 G-X-G motif; other site 158878000867 two-component response regulator; Provisional; Region: PRK14084 158878000868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878000869 active site 158878000870 phosphorylation site [posttranslational modification] 158878000871 intermolecular recognition site; other site 158878000872 dimerization interface [polypeptide binding]; other site 158878000873 LytTr DNA-binding domain; Region: LytTR; pfam04397 158878000874 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 158878000875 antiholin-like protein LrgB; Provisional; Region: PRK04288 158878000876 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 158878000877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158878000878 DNA-binding site [nucleotide binding]; DNA binding site 158878000879 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 158878000880 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 158878000881 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 158878000882 HPr interaction site; other site 158878000883 glycerol kinase (GK) interaction site [polypeptide binding]; other site 158878000884 active site 158878000885 phosphorylation site [posttranslational modification] 158878000886 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 158878000887 beta-galactosidase; Region: BGL; TIGR03356 158878000888 Methyltransferase domain; Region: Methyltransf_31; pfam13847 158878000889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878000890 S-adenosylmethionine binding site [chemical binding]; other site 158878000891 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158878000892 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 158878000893 substrate binding site [chemical binding]; other site 158878000894 dimer interface [polypeptide binding]; other site 158878000895 ATP binding site [chemical binding]; other site 158878000896 D-ribose pyranase; Provisional; Region: PRK11797 158878000897 Sugar transport protein; Region: Sugar_transport; pfam06800 158878000898 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158878000899 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158878000900 DNA binding site [nucleotide binding] 158878000901 domain linker motif; other site 158878000902 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158878000903 dimerization interface [polypeptide binding]; other site 158878000904 ligand binding site [chemical binding]; other site 158878000905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878000906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878000907 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 158878000908 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 158878000909 active site 158878000910 Surface antigen [General function prediction only]; Region: COG3942 158878000911 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 158878000912 Peptidase family M23; Region: Peptidase_M23; pfam01551 158878000913 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158878000914 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 158878000915 Walker A/P-loop; other site 158878000916 ATP binding site [chemical binding]; other site 158878000917 Q-loop/lid; other site 158878000918 ABC transporter signature motif; other site 158878000919 Walker B; other site 158878000920 D-loop; other site 158878000921 H-loop/switch region; other site 158878000922 Surface antigen [General function prediction only]; Region: COG3942 158878000923 CHAP domain; Region: CHAP; pfam05257 158878000924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 158878000925 Predicted membrane protein [Function unknown]; Region: COG1511 158878000926 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 158878000927 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 158878000928 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 158878000929 Uncharacterized small protein [Function unknown]; Region: COG5417 158878000930 Predicted membrane protein [Function unknown]; Region: COG4499 158878000931 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 158878000932 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 158878000933 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 158878000934 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 158878000935 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 158878000936 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 158878000937 Uncharacterized conserved protein [Function unknown]; Region: COG5444 158878000938 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 158878000939 Protein of unknown function, DUF600; Region: DUF600; cl04640 158878000940 Protein of unknown function, DUF600; Region: DUF600; cl04640 158878000941 Protein of unknown function, DUF600; Region: DUF600; cl04640 158878000942 Protein of unknown function, DUF600; Region: DUF600; cl04640 158878000943 Protein of unknown function, DUF600; Region: DUF600; cl04640 158878000944 Protein of unknown function, DUF600; Region: DUF600; cl04640 158878000945 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 158878000946 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 158878000947 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 158878000948 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 158878000949 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 158878000950 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 158878000951 FtsX-like permease family; Region: FtsX; pfam02687 158878000952 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158878000953 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158878000954 Walker A/P-loop; other site 158878000955 ATP binding site [chemical binding]; other site 158878000956 Q-loop/lid; other site 158878000957 ABC transporter signature motif; other site 158878000958 Walker B; other site 158878000959 D-loop; other site 158878000960 H-loop/switch region; other site 158878000961 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 158878000962 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 158878000963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878000964 non-specific DNA binding site [nucleotide binding]; other site 158878000965 salt bridge; other site 158878000966 sequence-specific DNA binding site [nucleotide binding]; other site 158878000967 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158878000968 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 158878000969 substrate binding site [chemical binding]; other site 158878000970 ATP binding site [chemical binding]; other site 158878000971 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 158878000972 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 158878000973 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 158878000974 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 158878000975 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 158878000976 putative transporter; Provisional; Region: PRK10484 158878000977 Na binding site [ion binding]; other site 158878000978 N-acetylneuraminate lyase; Provisional; Region: PRK04147 158878000979 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 158878000980 inhibitor site; inhibition site 158878000981 active site 158878000982 dimer interface [polypeptide binding]; other site 158878000983 catalytic residue [active] 158878000984 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158878000985 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158878000986 nucleotide binding site [chemical binding]; other site 158878000987 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 158878000988 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158878000989 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 158878000990 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 158878000991 putative active site [active] 158878000992 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 158878000993 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 158878000994 putative active site cavity [active] 158878000995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 158878000996 Nucleoside recognition; Region: Gate; pfam07670 158878000997 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 158878000998 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 158878000999 PGAP1-like protein; Region: PGAP1; pfam07819 158878001000 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 158878001001 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 158878001002 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 158878001003 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 158878001004 putative active site [active] 158878001005 putative FMN binding site [chemical binding]; other site 158878001006 putative substrate binding site [chemical binding]; other site 158878001007 putative catalytic residue [active] 158878001008 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 158878001009 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 158878001010 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 158878001011 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 158878001012 lipoyl attachment site [posttranslational modification]; other site 158878001013 Replication protein C N-terminal domain; Region: RP-C; pfam03428 158878001014 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 158878001015 putative ADP-ribose binding site [chemical binding]; other site 158878001016 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 158878001017 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 158878001018 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 158878001019 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 158878001020 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 158878001021 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 158878001022 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 158878001023 NADP binding site [chemical binding]; other site 158878001024 putative substrate binding site [chemical binding]; other site 158878001025 active site 158878001026 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 158878001027 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 158878001028 active site 158878001029 P-loop; other site 158878001030 phosphorylation site [posttranslational modification] 158878001031 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158878001032 active site 158878001033 phosphorylation site [posttranslational modification] 158878001034 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 158878001035 HTH domain; Region: HTH_11; pfam08279 158878001036 HTH domain; Region: HTH_11; pfam08279 158878001037 PRD domain; Region: PRD; pfam00874 158878001038 PRD domain; Region: PRD; pfam00874 158878001039 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 158878001040 active site 158878001041 P-loop; other site 158878001042 phosphorylation site [posttranslational modification] 158878001043 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158878001044 active site 158878001045 phosphorylation site [posttranslational modification] 158878001046 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 158878001047 MarR family; Region: MarR_2; pfam12802 158878001048 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158878001049 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 158878001050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 158878001051 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 158878001052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878001053 putative substrate translocation pore; other site 158878001054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878001055 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 158878001056 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158878001057 Zn binding site [ion binding]; other site 158878001058 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 158878001059 Zn binding site [ion binding]; other site 158878001060 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 158878001061 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 158878001062 Predicted flavoprotein [General function prediction only]; Region: COG0431 158878001063 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 158878001064 Predicted membrane protein [Function unknown]; Region: COG2855 158878001065 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 158878001066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158878001067 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 158878001068 Imelysin; Region: Peptidase_M75; pfam09375 158878001069 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 158878001070 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 158878001071 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 158878001072 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 158878001073 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 158878001074 Phage envelope protein [General function prediction only]; Region: COG5562 158878001075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878001076 non-specific DNA binding site [nucleotide binding]; other site 158878001077 salt bridge; other site 158878001078 sequence-specific DNA binding site [nucleotide binding]; other site 158878001079 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 158878001080 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 158878001081 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158878001082 Walker A/P-loop; other site 158878001083 ATP binding site [chemical binding]; other site 158878001084 Q-loop/lid; other site 158878001085 ABC transporter signature motif; other site 158878001086 Walker B; other site 158878001087 D-loop; other site 158878001088 H-loop/switch region; other site 158878001089 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 158878001090 Predicted membrane protein [Function unknown]; Region: COG4292 158878001091 putative acyltransferase; Provisional; Region: PRK05790 158878001092 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 158878001093 dimer interface [polypeptide binding]; other site 158878001094 active site 158878001095 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 158878001096 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 158878001097 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 158878001098 THF binding site; other site 158878001099 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 158878001100 substrate binding site [chemical binding]; other site 158878001101 THF binding site; other site 158878001102 zinc-binding site [ion binding]; other site 158878001103 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 158878001104 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 158878001105 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 158878001106 FAD binding site [chemical binding]; other site 158878001107 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 158878001108 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 158878001109 homodimer interface [polypeptide binding]; other site 158878001110 substrate-cofactor binding pocket; other site 158878001111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878001112 catalytic residue [active] 158878001113 cystathionine gamma-synthase; Reviewed; Region: PRK08247 158878001114 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158878001115 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158878001116 catalytic residue [active] 158878001117 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 158878001118 ParB-like nuclease domain; Region: ParB; smart00470 158878001119 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 158878001120 Mechanosensitive ion channel; Region: MS_channel; pfam00924 158878001121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 158878001122 GTP-binding protein YchF; Reviewed; Region: PRK09601 158878001123 YchF GTPase; Region: YchF; cd01900 158878001124 G1 box; other site 158878001125 GTP/Mg2+ binding site [chemical binding]; other site 158878001126 Switch I region; other site 158878001127 G2 box; other site 158878001128 Switch II region; other site 158878001129 G3 box; other site 158878001130 G4 box; other site 158878001131 G5 box; other site 158878001132 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 158878001133 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 158878001134 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 158878001135 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 158878001136 dimer interface [polypeptide binding]; other site 158878001137 ssDNA binding site [nucleotide binding]; other site 158878001138 tetramer (dimer of dimers) interface [polypeptide binding]; other site 158878001139 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 158878001140 Abi-like protein; Region: Abi_2; pfam07751 158878001141 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158878001142 DNA binding site [nucleotide binding] 158878001143 active site 158878001144 Int/Topo IB signature motif; other site 158878001145 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878001146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 158878001147 Predicted membrane protein [Function unknown]; Region: COG3212 158878001148 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 158878001149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 158878001150 non-specific DNA binding site [nucleotide binding]; other site 158878001151 salt bridge; other site 158878001152 sequence-specific DNA binding site [nucleotide binding]; other site 158878001153 Predicted membrane protein [Function unknown]; Region: COG2261 158878001154 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 158878001155 catalytic core [active] 158878001156 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 158878001157 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 158878001158 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 158878001159 catalytic residue [active] 158878001160 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 158878001161 catalytic residues [active] 158878001162 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158878001163 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158878001164 peroxiredoxin; Region: AhpC; TIGR03137 158878001165 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 158878001166 dimer interface [polypeptide binding]; other site 158878001167 decamer (pentamer of dimers) interface [polypeptide binding]; other site 158878001168 catalytic triad [active] 158878001169 peroxidatic and resolving cysteines [active] 158878001170 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 158878001171 dimer interface [polypeptide binding]; other site 158878001172 FMN binding site [chemical binding]; other site 158878001173 NADPH bind site [chemical binding]; other site 158878001174 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 158878001175 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 158878001176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 158878001177 Transposase; Region: DDE_Tnp_ISL3; pfam01610 158878001178 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158878001179 active site 158878001180 xanthine permease; Region: pbuX; TIGR03173 158878001181 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 158878001182 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 158878001183 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 158878001184 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 158878001185 active site 158878001186 GMP synthase; Reviewed; Region: guaA; PRK00074 158878001187 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 158878001188 AMP/PPi binding site [chemical binding]; other site 158878001189 candidate oxyanion hole; other site 158878001190 catalytic triad [active] 158878001191 potential glutamine specificity residues [chemical binding]; other site 158878001192 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 158878001193 ATP Binding subdomain [chemical binding]; other site 158878001194 Ligand Binding sites [chemical binding]; other site 158878001195 Dimerization subdomain; other site 158878001196 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 158878001197 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 158878001198 Int/Topo IB signature motif; other site 158878001199 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 158878001200 Helix-turn-helix domain; Region: HTH_16; pfam12645 158878001201 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 158878001202 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 158878001203 DNA binding residues [nucleotide binding] 158878001204 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158878001205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878001206 non-specific DNA binding site [nucleotide binding]; other site 158878001207 salt bridge; other site 158878001208 sequence-specific DNA binding site [nucleotide binding]; other site 158878001209 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 158878001210 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 158878001211 G1 box; other site 158878001212 putative GEF interaction site [polypeptide binding]; other site 158878001213 GTP/Mg2+ binding site [chemical binding]; other site 158878001214 Switch I region; other site 158878001215 G2 box; other site 158878001216 G3 box; other site 158878001217 Switch II region; other site 158878001218 G4 box; other site 158878001219 G5 box; other site 158878001220 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 158878001221 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 158878001222 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 158878001223 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 158878001224 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 158878001225 N-acetyl-D-glucosamine binding site [chemical binding]; other site 158878001226 catalytic residue [active] 158878001227 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 158878001228 NlpC/P60 family; Region: NLPC_P60; pfam00877 158878001229 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 158878001230 AAA-like domain; Region: AAA_10; pfam12846 158878001231 TcpE family; Region: TcpE; pfam12648 158878001232 Antirestriction protein (ArdA); Region: ArdA; pfam07275 158878001233 Abortive infection C-terminus; Region: Abi_C; pfam14355 158878001234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878001235 non-specific DNA binding site [nucleotide binding]; other site 158878001236 salt bridge; other site 158878001237 sequence-specific DNA binding site [nucleotide binding]; other site 158878001238 Replication initiation factor; Region: Rep_trans; pfam02486 158878001239 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 158878001240 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 158878001241 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 158878001242 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 158878001243 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 158878001244 Part of AAA domain; Region: AAA_19; pfam13245 158878001245 Family description; Region: UvrD_C_2; pfam13538 158878001246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158878001247 AAA domain; Region: AAA_21; pfam13304 158878001248 Walker A/P-loop; other site 158878001249 ATP binding site [chemical binding]; other site 158878001250 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 158878001251 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 158878001252 putative active site [active] 158878001253 putative metal-binding site [ion binding]; other site 158878001254 Transposase, Mutator family; Region: Transposase_mut; pfam00872 158878001255 MULE transposase domain; Region: MULE; pfam10551 158878001256 PemK-like protein; Region: PemK; pfam02452 158878001257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 158878001258 Transposase; Region: HTH_Tnp_1; cl17663 158878001259 Predicted membrane protein [Function unknown]; Region: COG3759 158878001260 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 158878001261 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 158878001262 NADP binding site [chemical binding]; other site 158878001263 superantigen-like protein; Reviewed; Region: PRK13037 158878001264 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 158878001265 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878001266 superantigen-like protein; Reviewed; Region: PRK13041 158878001267 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 158878001268 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878001269 superantigen-like protein; Reviewed; Region: PRK13335 158878001270 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 158878001271 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878001272 superantigen-like protein 5; Reviewed; Region: PRK13035 158878001273 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 158878001274 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878001275 superantigen-like protein 7; Reviewed; Region: PRK13346 158878001276 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 158878001277 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878001278 superantigen-like protein; Reviewed; Region: PRK13039 158878001279 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 158878001280 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878001281 superantigen-like protein; Reviewed; Region: PRK13345 158878001282 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 158878001283 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878001284 superantigen-like protein 5; Reviewed; Region: PRK13035 158878001285 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 158878001286 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878001287 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 158878001288 HsdM N-terminal domain; Region: HsdM_N; pfam12161 158878001289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878001290 S-adenosylmethionine binding site [chemical binding]; other site 158878001291 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 158878001292 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 158878001293 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 158878001294 superantigen-like protein; Reviewed; Region: PRK13036 158878001295 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 158878001296 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878001297 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878001298 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878001299 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878001300 Protein of unknown function, DUF576; Region: DUF576; cl04553 158878001301 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878001302 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878001303 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878001304 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878001305 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878001306 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878001307 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 158878001308 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 158878001309 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 158878001310 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 158878001311 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 158878001312 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 158878001313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 158878001314 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 158878001315 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 158878001316 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 158878001317 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 158878001318 active site 158878001319 Esterase/lipase [General function prediction only]; Region: COG1647 158878001320 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 158878001321 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 158878001322 Na2 binding site [ion binding]; other site 158878001323 putative substrate binding site 1 [chemical binding]; other site 158878001324 Na binding site 1 [ion binding]; other site 158878001325 putative substrate binding site 2 [chemical binding]; other site 158878001326 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 158878001327 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 158878001328 dimer interface [polypeptide binding]; other site 158878001329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878001330 catalytic residue [active] 158878001331 cystathionine beta-lyase; Provisional; Region: PRK07671 158878001332 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 158878001333 homodimer interface [polypeptide binding]; other site 158878001334 substrate-cofactor binding pocket; other site 158878001335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878001336 catalytic residue [active] 158878001337 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 158878001338 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 158878001339 Walker A/P-loop; other site 158878001340 ATP binding site [chemical binding]; other site 158878001341 Q-loop/lid; other site 158878001342 ABC transporter signature motif; other site 158878001343 Walker B; other site 158878001344 D-loop; other site 158878001345 H-loop/switch region; other site 158878001346 NIL domain; Region: NIL; pfam09383 158878001347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878001348 dimer interface [polypeptide binding]; other site 158878001349 conserved gate region; other site 158878001350 ABC-ATPase subunit interface; other site 158878001351 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 158878001352 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 158878001353 LysM domain; Region: LysM; pfam01476 158878001354 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 158878001355 Surface antigen [General function prediction only]; Region: COG3942 158878001356 CHAP domain; Region: CHAP; pfam05257 158878001357 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 158878001358 nudix motif; other site 158878001359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878001360 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158878001361 Coenzyme A binding pocket [chemical binding]; other site 158878001362 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 158878001363 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 158878001364 Transcriptional regulator [Transcription]; Region: LysR; COG0583 158878001365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 158878001366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 158878001367 dimerization interface [polypeptide binding]; other site 158878001368 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 158878001369 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 158878001370 active site 158878001371 dimer interface [polypeptide binding]; other site 158878001372 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 158878001373 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 158878001374 active site 158878001375 FMN binding site [chemical binding]; other site 158878001376 substrate binding site [chemical binding]; other site 158878001377 3Fe-4S cluster binding site [ion binding]; other site 158878001378 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 158878001379 domain interface; other site 158878001380 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 158878001381 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158878001382 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 158878001383 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 158878001384 active site turn [active] 158878001385 phosphorylation site [posttranslational modification] 158878001386 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 158878001387 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 158878001388 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 158878001389 Ca binding site [ion binding]; other site 158878001390 active site 158878001391 catalytic site [active] 158878001392 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 158878001393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158878001394 DNA-binding site [nucleotide binding]; DNA binding site 158878001395 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 158878001396 UTRA domain; Region: UTRA; pfam07702 158878001397 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158878001398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878001399 Coenzyme A binding pocket [chemical binding]; other site 158878001400 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 158878001401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878001402 Walker A motif; other site 158878001403 ATP binding site [chemical binding]; other site 158878001404 Walker B motif; other site 158878001405 arginine finger; other site 158878001406 hypothetical protein; Validated; Region: PRK00153 158878001407 recombination protein RecR; Reviewed; Region: recR; PRK00076 158878001408 RecR protein; Region: RecR; pfam02132 158878001409 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 158878001410 putative active site [active] 158878001411 putative metal-binding site [ion binding]; other site 158878001412 tetramer interface [polypeptide binding]; other site 158878001413 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 158878001414 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158878001415 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158878001416 catalytic residue [active] 158878001417 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 158878001418 thymidylate kinase; Validated; Region: tmk; PRK00698 158878001419 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 158878001420 TMP-binding site; other site 158878001421 ATP-binding site [chemical binding]; other site 158878001422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 158878001423 DNA polymerase III subunit delta'; Validated; Region: PRK08058 158878001424 DNA polymerase III subunit delta'; Validated; Region: PRK08485 158878001425 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 158878001426 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 158878001427 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 158878001428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878001429 S-adenosylmethionine binding site [chemical binding]; other site 158878001430 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 158878001431 GIY-YIG motif/motif A; other site 158878001432 putative active site [active] 158878001433 putative metal binding site [ion binding]; other site 158878001434 Predicted methyltransferases [General function prediction only]; Region: COG0313 158878001435 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 158878001436 putative SAM binding site [chemical binding]; other site 158878001437 putative homodimer interface [polypeptide binding]; other site 158878001438 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 158878001439 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 158878001440 active site 158878001441 HIGH motif; other site 158878001442 KMSKS motif; other site 158878001443 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 158878001444 tRNA binding surface [nucleotide binding]; other site 158878001445 anticodon binding site; other site 158878001446 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 158878001447 dimer interface [polypeptide binding]; other site 158878001448 putative tRNA-binding site [nucleotide binding]; other site 158878001449 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 158878001450 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 158878001451 active site 158878001452 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 158878001453 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 158878001454 putative active site [active] 158878001455 putative metal binding site [ion binding]; other site 158878001456 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 158878001457 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 158878001458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878001459 S-adenosylmethionine binding site [chemical binding]; other site 158878001460 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 158878001461 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 158878001462 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 158878001463 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 158878001464 pur operon repressor; Provisional; Region: PRK09213 158878001465 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 158878001466 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158878001467 active site 158878001468 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 158878001469 homotrimer interaction site [polypeptide binding]; other site 158878001470 putative active site [active] 158878001471 regulatory protein SpoVG; Reviewed; Region: PRK13259 158878001472 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 158878001473 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 158878001474 Substrate binding site; other site 158878001475 Mg++ binding site; other site 158878001476 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 158878001477 active site 158878001478 substrate binding site [chemical binding]; other site 158878001479 CoA binding site [chemical binding]; other site 158878001480 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 158878001481 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 158878001482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158878001483 active site 158878001484 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 158878001485 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 158878001486 5S rRNA interface [nucleotide binding]; other site 158878001487 CTC domain interface [polypeptide binding]; other site 158878001488 L16 interface [polypeptide binding]; other site 158878001489 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 158878001490 putative active site [active] 158878001491 catalytic residue [active] 158878001492 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 158878001493 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 158878001494 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158878001495 ATP binding site [chemical binding]; other site 158878001496 putative Mg++ binding site [ion binding]; other site 158878001497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158878001498 nucleotide binding region [chemical binding]; other site 158878001499 ATP-binding site [chemical binding]; other site 158878001500 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 158878001501 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 158878001502 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 158878001503 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 158878001504 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 158878001505 putative SAM binding site [chemical binding]; other site 158878001506 putative homodimer interface [polypeptide binding]; other site 158878001507 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 158878001508 homodimer interface [polypeptide binding]; other site 158878001509 metal binding site [ion binding]; metal-binding site 158878001510 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 158878001511 RNA binding surface [nucleotide binding]; other site 158878001512 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 158878001513 Septum formation initiator; Region: DivIC; pfam04977 158878001514 hypothetical protein; Provisional; Region: PRK08582 158878001515 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 158878001516 RNA binding site [nucleotide binding]; other site 158878001517 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 158878001518 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 158878001519 Ligand Binding Site [chemical binding]; other site 158878001520 TilS substrate C-terminal domain; Region: TilS_C; smart00977 158878001521 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 158878001522 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158878001523 active site 158878001524 FtsH Extracellular; Region: FtsH_ext; pfam06480 158878001525 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 158878001526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878001527 Walker A motif; other site 158878001528 ATP binding site [chemical binding]; other site 158878001529 Walker B motif; other site 158878001530 arginine finger; other site 158878001531 Peptidase family M41; Region: Peptidase_M41; pfam01434 158878001532 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 158878001533 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 158878001534 dimerization interface [polypeptide binding]; other site 158878001535 domain crossover interface; other site 158878001536 redox-dependent activation switch; other site 158878001537 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 158878001538 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 158878001539 dimer interface [polypeptide binding]; other site 158878001540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878001541 catalytic residue [active] 158878001542 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 158878001543 dihydropteroate synthase; Region: DHPS; TIGR01496 158878001544 substrate binding pocket [chemical binding]; other site 158878001545 dimer interface [polypeptide binding]; other site 158878001546 inhibitor binding site; inhibition site 158878001547 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 158878001548 homooctamer interface [polypeptide binding]; other site 158878001549 active site 158878001550 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 158878001551 catalytic center binding site [active] 158878001552 ATP binding site [chemical binding]; other site 158878001553 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 158878001554 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 158878001555 dimer interface [polypeptide binding]; other site 158878001556 putative anticodon binding site; other site 158878001557 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 158878001558 motif 1; other site 158878001559 active site 158878001560 motif 2; other site 158878001561 motif 3; other site 158878001562 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 158878001563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158878001564 DNA-binding site [nucleotide binding]; DNA binding site 158878001565 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158878001566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878001567 homodimer interface [polypeptide binding]; other site 158878001568 catalytic residue [active] 158878001569 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 158878001570 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 158878001571 active site 158878001572 multimer interface [polypeptide binding]; other site 158878001573 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 158878001574 predicted active site [active] 158878001575 catalytic triad [active] 158878001576 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 158878001577 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 158878001578 Nucleoside recognition; Region: Gate; pfam07670 158878001579 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 158878001580 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 158878001581 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 158878001582 UvrB/uvrC motif; Region: UVR; pfam02151 158878001583 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 158878001584 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 158878001585 ADP binding site [chemical binding]; other site 158878001586 phosphagen binding site; other site 158878001587 substrate specificity loop; other site 158878001588 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 158878001589 Clp amino terminal domain; Region: Clp_N; pfam02861 158878001590 Clp amino terminal domain; Region: Clp_N; pfam02861 158878001591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878001592 Walker A motif; other site 158878001593 ATP binding site [chemical binding]; other site 158878001594 Walker B motif; other site 158878001595 arginine finger; other site 158878001596 UvrB/uvrC motif; Region: UVR; pfam02151 158878001597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878001598 Walker A motif; other site 158878001599 ATP binding site [chemical binding]; other site 158878001600 Walker B motif; other site 158878001601 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 158878001602 DNA repair protein RadA; Provisional; Region: PRK11823 158878001603 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 158878001604 Walker A motif/ATP binding site; other site 158878001605 ATP binding site [chemical binding]; other site 158878001606 Walker B motif; other site 158878001607 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 158878001608 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 158878001609 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 158878001610 putative active site [active] 158878001611 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 158878001612 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 158878001613 active site 158878001614 HIGH motif; other site 158878001615 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 158878001616 active site 158878001617 KMSKS motif; other site 158878001618 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 158878001619 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 158878001620 trimer interface [polypeptide binding]; other site 158878001621 active site 158878001622 substrate binding site [chemical binding]; other site 158878001623 CoA binding site [chemical binding]; other site 158878001624 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 158878001625 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 158878001626 active site 158878001627 HIGH motif; other site 158878001628 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 158878001629 KMSKS motif; other site 158878001630 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 158878001631 tRNA binding surface [nucleotide binding]; other site 158878001632 anticodon binding site; other site 158878001633 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 158878001634 active site 158878001635 dimerization interface [polypeptide binding]; other site 158878001636 metal binding site [ion binding]; metal-binding site 158878001637 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 158878001638 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 158878001639 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 158878001640 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 158878001641 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 158878001642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 158878001643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 158878001644 DNA binding residues [nucleotide binding] 158878001645 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 158878001646 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 158878001647 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 158878001648 putative homodimer interface [polypeptide binding]; other site 158878001649 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 158878001650 heterodimer interface [polypeptide binding]; other site 158878001651 homodimer interface [polypeptide binding]; other site 158878001652 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 158878001653 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 158878001654 23S rRNA interface [nucleotide binding]; other site 158878001655 L7/L12 interface [polypeptide binding]; other site 158878001656 putative thiostrepton binding site; other site 158878001657 L25 interface [polypeptide binding]; other site 158878001658 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 158878001659 mRNA/rRNA interface [nucleotide binding]; other site 158878001660 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 158878001661 23S rRNA interface [nucleotide binding]; other site 158878001662 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 158878001663 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 158878001664 peripheral dimer interface [polypeptide binding]; other site 158878001665 core dimer interface [polypeptide binding]; other site 158878001666 L10 interface [polypeptide binding]; other site 158878001667 L11 interface [polypeptide binding]; other site 158878001668 putative EF-Tu interaction site [polypeptide binding]; other site 158878001669 putative EF-G interaction site [polypeptide binding]; other site 158878001670 Methyltransferase domain; Region: Methyltransf_31; pfam13847 158878001671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878001672 S-adenosylmethionine binding site [chemical binding]; other site 158878001673 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 158878001674 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 158878001675 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 158878001676 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 158878001677 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 158878001678 RPB10 interaction site [polypeptide binding]; other site 158878001679 RPB1 interaction site [polypeptide binding]; other site 158878001680 RPB11 interaction site [polypeptide binding]; other site 158878001681 RPB3 interaction site [polypeptide binding]; other site 158878001682 RPB12 interaction site [polypeptide binding]; other site 158878001683 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 158878001684 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 158878001685 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 158878001686 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 158878001687 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 158878001688 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 158878001689 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 158878001690 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 158878001691 G-loop; other site 158878001692 DNA binding site [nucleotide binding] 158878001693 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 158878001694 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 158878001695 S17 interaction site [polypeptide binding]; other site 158878001696 S8 interaction site; other site 158878001697 16S rRNA interaction site [nucleotide binding]; other site 158878001698 streptomycin interaction site [chemical binding]; other site 158878001699 23S rRNA interaction site [nucleotide binding]; other site 158878001700 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 158878001701 30S ribosomal protein S7; Validated; Region: PRK05302 158878001702 elongation factor G; Reviewed; Region: PRK00007 158878001703 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 158878001704 G1 box; other site 158878001705 putative GEF interaction site [polypeptide binding]; other site 158878001706 GTP/Mg2+ binding site [chemical binding]; other site 158878001707 Switch I region; other site 158878001708 G2 box; other site 158878001709 G3 box; other site 158878001710 Switch II region; other site 158878001711 G4 box; other site 158878001712 G5 box; other site 158878001713 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 158878001714 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 158878001715 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 158878001716 elongation factor Tu; Reviewed; Region: PRK00049 158878001717 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 158878001718 G1 box; other site 158878001719 GEF interaction site [polypeptide binding]; other site 158878001720 GTP/Mg2+ binding site [chemical binding]; other site 158878001721 Switch I region; other site 158878001722 G2 box; other site 158878001723 G3 box; other site 158878001724 Switch II region; other site 158878001725 G4 box; other site 158878001726 G5 box; other site 158878001727 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 158878001728 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 158878001729 Antibiotic Binding Site [chemical binding]; other site 158878001730 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 158878001731 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 158878001732 metal binding site [ion binding]; metal-binding site 158878001733 dimer interface [polypeptide binding]; other site 158878001734 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 158878001735 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 158878001736 substrate-cofactor binding pocket; other site 158878001737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878001738 catalytic residue [active] 158878001739 chaperone protein HchA; Provisional; Region: PRK04155 158878001740 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 158878001741 dimer interface [polypeptide binding]; other site 158878001742 metal binding site [ion binding]; metal-binding site 158878001743 potential oxyanion hole; other site 158878001744 potential catalytic triad [active] 158878001745 conserved cys residue [active] 158878001746 ribulokinase; Provisional; Region: PRK04123 158878001747 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 158878001748 N- and C-terminal domain interface [polypeptide binding]; other site 158878001749 active site 158878001750 MgATP binding site [chemical binding]; other site 158878001751 catalytic site [active] 158878001752 metal binding site [ion binding]; metal-binding site 158878001753 carbohydrate binding site [chemical binding]; other site 158878001754 homodimer interface [polypeptide binding]; other site 158878001755 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 158878001756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158878001757 NAD(P) binding site [chemical binding]; other site 158878001758 active site 158878001759 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 158878001760 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 158878001761 homodimer interface [polypeptide binding]; other site 158878001762 substrate-cofactor binding pocket; other site 158878001763 catalytic residue [active] 158878001764 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 158878001765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878001766 motif II; other site 158878001767 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 158878001768 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 158878001769 Substrate-binding site [chemical binding]; other site 158878001770 Substrate specificity [chemical binding]; other site 158878001771 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 158878001772 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 158878001773 Substrate-binding site [chemical binding]; other site 158878001774 Substrate specificity [chemical binding]; other site 158878001775 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 158878001776 nucleoside/Zn binding site; other site 158878001777 dimer interface [polypeptide binding]; other site 158878001778 catalytic motif [active] 158878001779 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878001780 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 158878001781 active site 158878001782 motif I; other site 158878001783 motif II; other site 158878001784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878001785 Predicted flavoprotein [General function prediction only]; Region: COG0431 158878001786 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 158878001787 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 158878001788 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 158878001789 Cna protein B-type domain; Region: Cna_B; pfam05738 158878001790 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 158878001791 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 158878001792 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 158878001793 Cna protein B-type domain; Region: Cna_B; pfam05738 158878001794 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 158878001795 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 158878001796 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 158878001797 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 158878001798 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 158878001799 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 158878001800 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 158878001801 Cna protein B-type domain; Region: Cna_B; pfam05738 158878001802 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 158878001803 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 158878001804 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 158878001805 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158878001806 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 158878001807 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 158878001808 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158878001809 putative GTP cyclohydrolase; Provisional; Region: PRK13674 158878001810 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 158878001811 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 158878001812 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 158878001813 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 158878001814 active site 158878001815 trimer interface [polypeptide binding]; other site 158878001816 allosteric site; other site 158878001817 active site lid [active] 158878001818 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158878001819 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 158878001820 active site 158878001821 dimer interface [polypeptide binding]; other site 158878001822 magnesium binding site [ion binding]; other site 158878001823 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 158878001824 tetramer interface [polypeptide binding]; other site 158878001825 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158878001826 active site 158878001827 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 158878001828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878001829 motif II; other site 158878001830 proline/glycine betaine transporter; Provisional; Region: PRK10642 158878001831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878001832 putative substrate translocation pore; other site 158878001833 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 158878001834 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 158878001835 acyl-activating enzyme (AAE) consensus motif; other site 158878001836 AMP binding site [chemical binding]; other site 158878001837 active site 158878001838 CoA binding site [chemical binding]; other site 158878001839 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 158878001840 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 158878001841 dimer interface [polypeptide binding]; other site 158878001842 active site 158878001843 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 158878001844 dimer interface [polypeptide binding]; other site 158878001845 substrate binding site [chemical binding]; other site 158878001846 ATP binding site [chemical binding]; other site 158878001847 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 158878001848 ligand binding site [chemical binding]; other site 158878001849 active site 158878001850 UGI interface [polypeptide binding]; other site 158878001851 catalytic site [active] 158878001852 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 158878001853 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 158878001854 Uncharacterized conserved protein [Function unknown]; Region: COG3610 158878001855 Uncharacterized conserved protein [Function unknown]; Region: COG2966 158878001856 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 158878001857 putative heme peroxidase; Provisional; Region: PRK12276 158878001858 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 158878001859 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 158878001860 mevalonate kinase; Region: mevalon_kin; TIGR00549 158878001861 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 158878001862 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 158878001863 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 158878001864 diphosphomevalonate decarboxylase; Region: PLN02407 158878001865 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 158878001866 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 158878001867 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 158878001868 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 158878001869 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 158878001870 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 158878001871 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158878001872 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 158878001873 Predicted transcriptional regulator [Transcription]; Region: COG1959 158878001874 Transcriptional regulator; Region: Rrf2; pfam02082 158878001875 LXG domain of WXG superfamily; Region: LXG; pfam04740 158878001876 Protein of unknown function (DUF443); Region: DUF443; pfam04276 158878001877 Protein of unknown function (DUF443); Region: DUF443; pfam04276 158878001878 Protein of unknown function (DUF443); Region: DUF443; pfam04276 158878001879 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158878001880 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158878001881 active site 158878001882 catalytic tetrad [active] 158878001883 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 158878001884 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 158878001885 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 158878001886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878001887 Coenzyme A binding pocket [chemical binding]; other site 158878001888 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 158878001889 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158878001890 Zn2+ binding site [ion binding]; other site 158878001891 Mg2+ binding site [ion binding]; other site 158878001892 YwhD family; Region: YwhD; pfam08741 158878001893 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 158878001894 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 158878001895 NAD binding site [chemical binding]; other site 158878001896 substrate binding site [chemical binding]; other site 158878001897 catalytic Zn binding site [ion binding]; other site 158878001898 tetramer interface [polypeptide binding]; other site 158878001899 structural Zn binding site [ion binding]; other site 158878001900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 158878001901 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 158878001902 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 158878001903 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 158878001904 active site 158878001905 HIGH motif; other site 158878001906 KMSK motif region; other site 158878001907 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 158878001908 tRNA binding surface [nucleotide binding]; other site 158878001909 anticodon binding site; other site 158878001910 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 158878001911 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 158878001912 minor groove reading motif; other site 158878001913 helix-hairpin-helix signature motif; other site 158878001914 substrate binding pocket [chemical binding]; other site 158878001915 active site 158878001916 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 158878001917 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 158878001918 putative binding site residues; other site 158878001919 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158878001920 ABC-ATPase subunit interface; other site 158878001921 dimer interface [polypeptide binding]; other site 158878001922 putative PBP binding regions; other site 158878001923 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 158878001924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878001925 motif II; other site 158878001926 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 158878001927 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 158878001928 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 158878001929 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 158878001930 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 158878001931 Transcriptional regulators [Transcription]; Region: MarR; COG1846 158878001932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 158878001933 Protein of unknown function, DUF606; Region: DUF606; pfam04657 158878001934 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 158878001935 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158878001936 active site 158878001937 DNA binding site [nucleotide binding] 158878001938 Int/Topo IB signature motif; other site 158878001939 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 158878001940 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 158878001941 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 158878001942 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 158878001943 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 158878001944 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 158878001945 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 158878001946 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 158878001947 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 158878001948 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 158878001949 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 158878001950 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 158878001951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 158878001952 Transposase; Region: DDE_Tnp_ISL3; pfam01610 158878001953 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 158878001954 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 158878001955 metal binding site [ion binding]; metal-binding site 158878001956 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 158878001957 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158878001958 ABC-ATPase subunit interface; other site 158878001959 dimer interface [polypeptide binding]; other site 158878001960 putative PBP binding regions; other site 158878001961 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 158878001962 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 158878001963 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 158878001964 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 158878001965 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 158878001966 FeoA domain; Region: FeoA; pfam04023 158878001967 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 158878001968 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 158878001969 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 158878001970 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 158878001971 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 158878001972 Walker A/P-loop; other site 158878001973 ATP binding site [chemical binding]; other site 158878001974 Q-loop/lid; other site 158878001975 ABC transporter signature motif; other site 158878001976 Walker B; other site 158878001977 D-loop; other site 158878001978 H-loop/switch region; other site 158878001979 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 158878001980 ABC-2 type transporter; Region: ABC2_membrane; cl17235 158878001981 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 158878001982 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 158878001983 active site 158878001984 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158878001985 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 158878001986 active site 158878001987 nucleotide binding site [chemical binding]; other site 158878001988 HIGH motif; other site 158878001989 KMSKS motif; other site 158878001990 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 158878001991 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 158878001992 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 158878001993 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 158878001994 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 158878001995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158878001996 Walker A/P-loop; other site 158878001997 ATP binding site [chemical binding]; other site 158878001998 Q-loop/lid; other site 158878001999 ABC transporter signature motif; other site 158878002000 Walker B; other site 158878002001 D-loop; other site 158878002002 H-loop/switch region; other site 158878002003 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 158878002004 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 158878002005 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 158878002006 Uncharacterized conserved protein [Function unknown]; Region: COG1284 158878002007 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 158878002008 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 158878002009 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 158878002010 Walker A/P-loop; other site 158878002011 ATP binding site [chemical binding]; other site 158878002012 Q-loop/lid; other site 158878002013 ABC transporter signature motif; other site 158878002014 Walker B; other site 158878002015 D-loop; other site 158878002016 H-loop/switch region; other site 158878002017 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 158878002018 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158878002019 ABC-ATPase subunit interface; other site 158878002020 dimer interface [polypeptide binding]; other site 158878002021 putative PBP binding regions; other site 158878002022 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 158878002023 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158878002024 ABC-ATPase subunit interface; other site 158878002025 dimer interface [polypeptide binding]; other site 158878002026 putative PBP binding regions; other site 158878002027 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 158878002028 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 158878002029 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 158878002030 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 158878002031 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 158878002032 Uncharacterized membrane protein [Function unknown]; Region: COG3949 158878002033 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 158878002034 Na binding site [ion binding]; other site 158878002035 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 158878002036 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 158878002037 substrate binding pocket [chemical binding]; other site 158878002038 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 158878002039 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158878002040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878002041 Coenzyme A binding pocket [chemical binding]; other site 158878002042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158878002043 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 158878002044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158878002045 NAD(P) binding site [chemical binding]; other site 158878002046 active site 158878002047 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158878002048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878002049 active site 158878002050 phosphorylation site [posttranslational modification] 158878002051 intermolecular recognition site; other site 158878002052 dimerization interface [polypeptide binding]; other site 158878002053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158878002054 DNA binding site [nucleotide binding] 158878002055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158878002056 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 158878002057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878002058 ATP binding site [chemical binding]; other site 158878002059 Mg2+ binding site [ion binding]; other site 158878002060 G-X-G motif; other site 158878002061 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158878002062 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158878002063 Walker A/P-loop; other site 158878002064 ATP binding site [chemical binding]; other site 158878002065 Q-loop/lid; other site 158878002066 ABC transporter signature motif; other site 158878002067 Walker B; other site 158878002068 D-loop; other site 158878002069 H-loop/switch region; other site 158878002070 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 158878002071 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 158878002072 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 158878002073 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 158878002074 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 158878002075 Surface antigen [General function prediction only]; Region: COG3942 158878002076 CHAP domain; Region: CHAP; pfam05257 158878002077 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 158878002078 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 158878002079 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158878002080 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 158878002081 hypothetical protein; Provisional; Region: PRK12378 158878002082 Uncharacterized conserved protein [Function unknown]; Region: COG3542 158878002083 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 158878002084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 158878002085 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 158878002086 dimerization interface [polypeptide binding]; other site 158878002087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878002088 sugar efflux transporter; Region: 2A0120; TIGR00899 158878002089 putative substrate translocation pore; other site 158878002090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 158878002091 Serine incorporator (Serinc); Region: Serinc; pfam03348 158878002092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878002093 Coenzyme A binding pocket [chemical binding]; other site 158878002094 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 158878002095 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 158878002096 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 158878002097 hypothetical protein; Validated; Region: PRK00124 158878002098 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 158878002099 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 158878002100 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 158878002101 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 158878002102 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 158878002103 Walker A/P-loop; other site 158878002104 ATP binding site [chemical binding]; other site 158878002105 Q-loop/lid; other site 158878002106 ABC transporter signature motif; other site 158878002107 Walker B; other site 158878002108 D-loop; other site 158878002109 H-loop/switch region; other site 158878002110 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 158878002111 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 158878002112 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 158878002113 Walker A/P-loop; other site 158878002114 ATP binding site [chemical binding]; other site 158878002115 Q-loop/lid; other site 158878002116 ABC transporter signature motif; other site 158878002117 Walker B; other site 158878002118 D-loop; other site 158878002119 H-loop/switch region; other site 158878002120 Transcriptional regulators [Transcription]; Region: MarR; COG1846 158878002121 MarR family; Region: MarR; pfam01047 158878002122 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 158878002123 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 158878002124 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 158878002125 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158878002126 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158878002127 active site 158878002128 catalytic tetrad [active] 158878002129 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 158878002130 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 158878002131 transmembrane helices; other site 158878002132 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 158878002133 DNA photolyase; Region: DNA_photolyase; pfam00875 158878002134 Predicted membrane protein [Function unknown]; Region: COG4330 158878002135 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 158878002136 trimer interface [polypeptide binding]; other site 158878002137 putative Zn binding site [ion binding]; other site 158878002138 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 158878002139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878002140 putative substrate translocation pore; other site 158878002141 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 158878002142 putative deacylase active site [active] 158878002143 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 158878002144 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 158878002145 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 158878002146 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 158878002147 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 158878002148 putative substrate binding site [chemical binding]; other site 158878002149 putative ATP binding site [chemical binding]; other site 158878002150 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 158878002151 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158878002152 active site 158878002153 phosphorylation site [posttranslational modification] 158878002154 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 158878002155 active site 158878002156 P-loop; other site 158878002157 phosphorylation site [posttranslational modification] 158878002158 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 158878002159 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 158878002160 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 158878002161 active site 158878002162 dimer interface [polypeptide binding]; other site 158878002163 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 158878002164 Domain of unknown function DUF21; Region: DUF21; pfam01595 158878002165 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 158878002166 Transporter associated domain; Region: CorC_HlyC; pfam03471 158878002167 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158878002168 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158878002169 active site 158878002170 catalytic tetrad [active] 158878002171 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 158878002172 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 158878002173 Ligand binding site; other site 158878002174 Putative Catalytic site; other site 158878002175 DXD motif; other site 158878002176 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158878002177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158878002178 dimer interface [polypeptide binding]; other site 158878002179 phosphorylation site [posttranslational modification] 158878002180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878002181 ATP binding site [chemical binding]; other site 158878002182 Mg2+ binding site [ion binding]; other site 158878002183 G-X-G motif; other site 158878002184 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158878002185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878002186 active site 158878002187 phosphorylation site [posttranslational modification] 158878002188 intermolecular recognition site; other site 158878002189 dimerization interface [polypeptide binding]; other site 158878002190 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158878002191 DNA binding site [nucleotide binding] 158878002192 Electron transfer DM13; Region: DM13; pfam10517 158878002193 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 158878002194 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 158878002195 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 158878002196 active site 158878002197 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 158878002198 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 158878002199 Ligand Binding Site [chemical binding]; other site 158878002200 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 158878002201 Glutamine amidotransferase class-I; Region: GATase; pfam00117 158878002202 glutamine binding [chemical binding]; other site 158878002203 catalytic triad [active] 158878002204 aminodeoxychorismate synthase; Provisional; Region: PRK07508 158878002205 chorismate binding enzyme; Region: Chorismate_bind; cl10555 158878002206 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 158878002207 substrate-cofactor binding pocket; other site 158878002208 Aminotransferase class IV; Region: Aminotran_4; pfam01063 158878002209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878002210 catalytic residue [active] 158878002211 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 158878002212 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 158878002213 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 158878002214 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 158878002215 Sulfatase; Region: Sulfatase; pfam00884 158878002216 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 158878002217 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158878002218 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158878002219 ABC transporter; Region: ABC_tran_2; pfam12848 158878002220 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158878002221 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 158878002222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158878002223 ATP binding site [chemical binding]; other site 158878002224 putative Mg++ binding site [ion binding]; other site 158878002225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158878002226 nucleotide binding region [chemical binding]; other site 158878002227 ATP-binding site [chemical binding]; other site 158878002228 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 158878002229 HRDC domain; Region: HRDC; pfam00570 158878002230 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 158878002231 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 158878002232 Walker A/P-loop; other site 158878002233 ATP binding site [chemical binding]; other site 158878002234 Q-loop/lid; other site 158878002235 ABC transporter signature motif; other site 158878002236 Walker B; other site 158878002237 D-loop; other site 158878002238 H-loop/switch region; other site 158878002239 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 158878002240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878002241 dimer interface [polypeptide binding]; other site 158878002242 conserved gate region; other site 158878002243 ABC-ATPase subunit interface; other site 158878002244 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 158878002245 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 158878002246 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 158878002247 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158878002248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878002249 homodimer interface [polypeptide binding]; other site 158878002250 catalytic residue [active] 158878002251 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 158878002252 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 158878002253 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 158878002254 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 158878002255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878002256 putative substrate translocation pore; other site 158878002257 POT family; Region: PTR2; cl17359 158878002258 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 158878002259 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 158878002260 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 158878002261 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 158878002262 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 158878002263 Class I ribonucleotide reductase; Region: RNR_I; cd01679 158878002264 active site 158878002265 dimer interface [polypeptide binding]; other site 158878002266 catalytic residues [active] 158878002267 effector binding site; other site 158878002268 R2 peptide binding site; other site 158878002269 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 158878002270 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 158878002271 dimer interface [polypeptide binding]; other site 158878002272 putative radical transfer pathway; other site 158878002273 diiron center [ion binding]; other site 158878002274 tyrosyl radical; other site 158878002275 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158878002276 ABC-ATPase subunit interface; other site 158878002277 dimer interface [polypeptide binding]; other site 158878002278 putative PBP binding regions; other site 158878002279 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158878002280 ABC-ATPase subunit interface; other site 158878002281 dimer interface [polypeptide binding]; other site 158878002282 putative PBP binding regions; other site 158878002283 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 158878002284 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 158878002285 Walker A/P-loop; other site 158878002286 ATP binding site [chemical binding]; other site 158878002287 Q-loop/lid; other site 158878002288 ABC transporter signature motif; other site 158878002289 Walker B; other site 158878002290 D-loop; other site 158878002291 H-loop/switch region; other site 158878002292 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 158878002293 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 158878002294 putative ligand binding residues [chemical binding]; other site 158878002295 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 158878002296 CHY zinc finger; Region: zf-CHY; pfam05495 158878002297 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 158878002298 FAD binding domain; Region: FAD_binding_4; pfam01565 158878002299 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 158878002300 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 158878002301 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 158878002302 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 158878002303 peptidase T; Region: peptidase-T; TIGR01882 158878002304 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 158878002305 metal binding site [ion binding]; metal-binding site 158878002306 dimer interface [polypeptide binding]; other site 158878002307 Uncharacterized conserved protein [Function unknown]; Region: COG3610 158878002308 Uncharacterized conserved protein [Function unknown]; Region: COG2966 158878002309 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 158878002310 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 158878002311 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 158878002312 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158878002313 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158878002314 metal binding site [ion binding]; metal-binding site 158878002315 active site 158878002316 I-site; other site 158878002317 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 158878002318 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 158878002319 Mg++ binding site [ion binding]; other site 158878002320 putative catalytic motif [active] 158878002321 substrate binding site [chemical binding]; other site 158878002322 Uncharacterized conserved protein [Function unknown]; Region: COG1739 158878002323 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 158878002324 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 158878002325 EDD domain protein, DegV family; Region: DegV; TIGR00762 158878002326 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 158878002327 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 158878002328 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 158878002329 putative Mg++ binding site [ion binding]; other site 158878002330 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158878002331 nucleotide binding region [chemical binding]; other site 158878002332 ATP-binding site [chemical binding]; other site 158878002333 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 158878002334 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158878002335 active site 158878002336 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 158878002337 30S subunit binding site; other site 158878002338 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 158878002339 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 158878002340 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 158878002341 nucleotide binding region [chemical binding]; other site 158878002342 ATP-binding site [chemical binding]; other site 158878002343 SEC-C motif; Region: SEC-C; pfam02810 158878002344 peptide chain release factor 2; Provisional; Region: PRK06746 158878002345 This domain is found in peptide chain release factors; Region: PCRF; smart00937 158878002346 RF-1 domain; Region: RF-1; pfam00472 158878002347 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 158878002348 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 158878002349 Surface antigen [General function prediction only]; Region: COG3942 158878002350 CHAP domain; Region: CHAP; pfam05257 158878002351 HD domain; Region: HD_3; cl17350 158878002352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 158878002353 excinuclease ABC subunit B; Provisional; Region: PRK05298 158878002354 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158878002355 ATP binding site [chemical binding]; other site 158878002356 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158878002357 nucleotide binding region [chemical binding]; other site 158878002358 ATP-binding site [chemical binding]; other site 158878002359 Ultra-violet resistance protein B; Region: UvrB; pfam12344 158878002360 UvrB/uvrC motif; Region: UVR; pfam02151 158878002361 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 158878002362 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 158878002363 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 158878002364 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 158878002365 HPr kinase/phosphorylase; Provisional; Region: PRK05428 158878002366 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 158878002367 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 158878002368 Hpr binding site; other site 158878002369 active site 158878002370 homohexamer subunit interaction site [polypeptide binding]; other site 158878002371 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 158878002372 putative acyl transferase; Provisional; Region: PRK10191 158878002373 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 158878002374 trimer interface [polypeptide binding]; other site 158878002375 active site 158878002376 substrate binding site [chemical binding]; other site 158878002377 CoA binding site [chemical binding]; other site 158878002378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 158878002379 binding surface 158878002380 TPR motif; other site 158878002381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158878002382 TPR motif; other site 158878002383 binding surface 158878002384 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 158878002385 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158878002386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158878002387 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 158878002388 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 158878002389 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 158878002390 phosphate binding site [ion binding]; other site 158878002391 dimer interface [polypeptide binding]; other site 158878002392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 158878002393 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 158878002394 Clp protease; Region: CLP_protease; pfam00574 158878002395 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 158878002396 oligomer interface [polypeptide binding]; other site 158878002397 active site residues [active] 158878002398 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 158878002399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158878002400 NAD(P) binding site [chemical binding]; other site 158878002401 active site 158878002402 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 158878002403 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 158878002404 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 158878002405 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 158878002406 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 158878002407 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 158878002408 Phosphoglycerate kinase; Region: PGK; pfam00162 158878002409 substrate binding site [chemical binding]; other site 158878002410 hinge regions; other site 158878002411 ADP binding site [chemical binding]; other site 158878002412 catalytic site [active] 158878002413 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 158878002414 triosephosphate isomerase; Provisional; Region: PRK14565 158878002415 substrate binding site [chemical binding]; other site 158878002416 dimer interface [polypeptide binding]; other site 158878002417 catalytic triad [active] 158878002418 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 158878002419 phosphoglyceromutase; Provisional; Region: PRK05434 158878002420 enolase; Provisional; Region: eno; PRK00077 158878002421 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 158878002422 dimer interface [polypeptide binding]; other site 158878002423 metal binding site [ion binding]; metal-binding site 158878002424 substrate binding pocket [chemical binding]; other site 158878002425 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 158878002426 Esterase/lipase [General function prediction only]; Region: COG1647 158878002427 ribonuclease R; Region: RNase_R; TIGR02063 158878002428 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 158878002429 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 158878002430 RNB domain; Region: RNB; pfam00773 158878002431 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 158878002432 RNA binding site [nucleotide binding]; other site 158878002433 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 158878002434 SmpB-tmRNA interface; other site 158878002435 Bacteriophage Type-I nSa3 158878002436 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 158878002437 Int/Topo IB signature motif; other site 158878002438 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 158878002439 sequence-specific DNA binding site [nucleotide binding]; other site 158878002440 salt bridge; other site 158878002441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 158878002442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878002443 salt bridge; other site 158878002444 non-specific DNA binding site [nucleotide binding]; other site 158878002445 sequence-specific DNA binding site [nucleotide binding]; other site 158878002446 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 158878002447 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 158878002448 Virulence-associated protein E; Region: VirE; pfam05272 158878002449 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 158878002450 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 158878002451 Abi-like protein; Region: Abi_2; pfam07751 158878002452 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 158878002453 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 158878002454 putative ligand binding residues [chemical binding]; other site 158878002455 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 158878002456 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 158878002457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878002458 Coenzyme A binding pocket [chemical binding]; other site 158878002459 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 158878002460 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 158878002461 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 158878002462 Staphylococcal nuclease homologues; Region: SNc; smart00318 158878002463 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 158878002464 Catalytic site; other site 158878002465 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 158878002466 DNA-binding site [nucleotide binding]; DNA binding site 158878002467 RNA-binding motif; other site 158878002468 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 158878002469 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 158878002470 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 158878002471 catalytic core [active] 158878002472 Lysine efflux permease [General function prediction only]; Region: COG1279 158878002473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158878002474 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 158878002475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158878002476 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 158878002477 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 158878002478 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 158878002479 active site 158878002480 catalytic residue [active] 158878002481 dimer interface [polypeptide binding]; other site 158878002482 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 158878002483 putative FMN binding site [chemical binding]; other site 158878002484 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 158878002485 catalytic residues [active] 158878002486 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 158878002487 ArsC family; Region: ArsC; pfam03960 158878002488 putative ArsC-like catalytic residues; other site 158878002489 putative TRX-like catalytic residues [active] 158878002490 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 158878002491 lipoyl attachment site [posttranslational modification]; other site 158878002492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 158878002493 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 158878002494 putative active site [active] 158878002495 putative metal binding site [ion binding]; other site 158878002496 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 158878002497 catalytic residues [active] 158878002498 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 158878002499 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 158878002500 Walker A/P-loop; other site 158878002501 ATP binding site [chemical binding]; other site 158878002502 Q-loop/lid; other site 158878002503 ABC transporter signature motif; other site 158878002504 Walker B; other site 158878002505 D-loop; other site 158878002506 H-loop/switch region; other site 158878002507 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 158878002508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878002509 dimer interface [polypeptide binding]; other site 158878002510 conserved gate region; other site 158878002511 ABC-ATPase subunit interface; other site 158878002512 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 158878002513 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 158878002514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 158878002515 Predicted membrane protein [Function unknown]; Region: COG2035 158878002516 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 158878002517 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 158878002518 Walker A/P-loop; other site 158878002519 ATP binding site [chemical binding]; other site 158878002520 Q-loop/lid; other site 158878002521 ABC transporter signature motif; other site 158878002522 Walker B; other site 158878002523 D-loop; other site 158878002524 H-loop/switch region; other site 158878002525 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 158878002526 FeS assembly protein SufD; Region: sufD; TIGR01981 158878002527 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 158878002528 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 158878002529 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158878002530 catalytic residue [active] 158878002531 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 158878002532 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 158878002533 trimerization site [polypeptide binding]; other site 158878002534 active site 158878002535 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 158878002536 FeS assembly protein SufB; Region: sufB; TIGR01980 158878002537 Bacteriophage phi mu1 158878002538 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158878002539 active site 158878002540 DNA binding site [nucleotide binding] 158878002541 Int/Topo IB signature motif; other site 158878002542 Domain of unknown function (DUF955); Region: DUF955; pfam06114 158878002543 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158878002544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878002545 non-specific DNA binding site [nucleotide binding]; other site 158878002546 salt bridge; other site 158878002547 sequence-specific DNA binding site [nucleotide binding]; other site 158878002548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878002549 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158878002550 non-specific DNA binding site [nucleotide binding]; other site 158878002551 salt bridge; other site 158878002552 sequence-specific DNA binding site [nucleotide binding]; other site 158878002553 Prophage antirepressor [Transcription]; Region: COG3617 158878002554 BRO family, N-terminal domain; Region: Bro-N; smart01040 158878002555 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 158878002556 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 158878002557 Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656 158878002558 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 158878002559 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 158878002560 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 158878002561 dimer interface [polypeptide binding]; other site 158878002562 ssDNA binding site [nucleotide binding]; other site 158878002563 tetramer (dimer of dimers) interface [polypeptide binding]; other site 158878002564 NUMOD4 motif; Region: NUMOD4; pfam07463 158878002565 HNH endonuclease; Region: HNH_3; pfam13392 158878002566 Protein of unknown function (DUF968); Region: DUF968; pfam06147 158878002567 Helix-turn-helix domain; Region: HTH_36; pfam13730 158878002568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878002569 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 158878002570 Walker A motif; other site 158878002571 ATP binding site [chemical binding]; other site 158878002572 Walker B motif; other site 158878002573 arginine finger; other site 158878002574 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 158878002575 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 158878002576 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 158878002577 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 158878002578 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 158878002579 dUTPase; Region: dUTPase_2; pfam08761 158878002580 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 158878002581 active site 158878002582 homodimer interface [polypeptide binding]; other site 158878002583 metal binding site [ion binding]; metal-binding site 158878002584 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 158878002585 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 158878002586 Transcriptional activator RinB; Region: RinB; pfam06116 158878002587 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 158878002588 Terminase small subunit; Region: Terminase_2; pfam03592 158878002589 phage terminase, large subunit, PBSX family; Region: phage_term_2; TIGR01547 158878002590 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 158878002591 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 158878002592 phage putative head morphogenesis protein, SPP1 gp7 family; Region: phageSPP1_gp7; TIGR01641 158878002593 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 158878002594 Phage capsid family; Region: Phage_capsid; pfam05065 158878002595 Phage capsid family; Region: Phage_capsid; pfam05065 158878002596 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 158878002597 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 158878002598 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 158878002599 Phage protein; Region: DUF3647; pfam12363 158878002600 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 158878002601 Phage-related protein [Function unknown]; Region: COG5412 158878002602 membrane protein P6; Region: PHA01399 158878002603 Phage tail protein; Region: Sipho_tail; pfam05709 158878002604 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 158878002605 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 158878002606 active site 158878002607 catalytic triad [active] 158878002608 oxyanion hole [active] 158878002609 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 158878002610 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 158878002611 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 158878002612 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 158878002613 CHAP domain; Region: CHAP; pfam05257 158878002614 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 158878002615 Lysozyme subfamily 2; Region: LYZ2; smart00047 158878002616 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 158878002617 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 158878002618 Phage tail repeat like; Region: PTR; pfam12789 158878002619 Bacteriophage holin; Region: Phage_holin_1; pfam04531 158878002620 CHAP domain; Region: CHAP; pfam05257 158878002621 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 158878002622 amidase catalytic site [active] 158878002623 Zn binding residues [ion binding]; other site 158878002624 substrate binding site [chemical binding]; other site 158878002625 Bacterial SH3 domain; Region: SH3_5; pfam08460 158878002626 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 158878002627 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 158878002628 Domain of unknown function DUF21; Region: DUF21; pfam01595 158878002629 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 158878002630 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 158878002631 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 158878002632 FMN binding site [chemical binding]; other site 158878002633 substrate binding site [chemical binding]; other site 158878002634 putative catalytic residue [active] 158878002635 Uncharacterized conserved protein [Function unknown]; Region: COG1801 158878002636 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 158878002637 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 158878002638 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 158878002639 active site 158878002640 metal binding site [ion binding]; metal-binding site 158878002641 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 158878002642 lipoyl synthase; Provisional; Region: PRK05481 158878002643 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158878002644 FeS/SAM binding site; other site 158878002645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 158878002646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 158878002647 Transposase; Region: DDE_Tnp_ISL3; pfam01610 158878002648 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 158878002649 Uncharacterized conserved protein [Function unknown]; Region: COG2445 158878002650 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 158878002651 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878002652 active site 158878002653 motif I; other site 158878002654 motif II; other site 158878002655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878002656 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 158878002657 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 158878002658 dimerization interface [polypeptide binding]; other site 158878002659 ligand binding site [chemical binding]; other site 158878002660 NADP binding site [chemical binding]; other site 158878002661 catalytic site [active] 158878002662 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 158878002663 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 158878002664 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 158878002665 acyl-activating enzyme (AAE) consensus motif; other site 158878002666 AMP binding site [chemical binding]; other site 158878002667 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 158878002668 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 158878002669 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 158878002670 DltD N-terminal region; Region: DltD_N; pfam04915 158878002671 DltD central region; Region: DltD_M; pfam04918 158878002672 DltD C-terminal region; Region: DltD_C; pfam04914 158878002673 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 158878002674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 158878002675 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 158878002676 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158878002677 hypothetical protein; Provisional; Region: PRK13669 158878002678 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 158878002679 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 158878002680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158878002681 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 158878002682 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 158878002683 interface (dimer of trimers) [polypeptide binding]; other site 158878002684 Substrate-binding/catalytic site; other site 158878002685 Zn-binding sites [ion binding]; other site 158878002686 Predicted permease [General function prediction only]; Region: COG2056 158878002687 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 158878002688 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 158878002689 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 158878002690 CoenzymeA binding site [chemical binding]; other site 158878002691 subunit interaction site [polypeptide binding]; other site 158878002692 PHB binding site; other site 158878002693 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158878002694 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 158878002695 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 158878002696 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 158878002697 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 158878002698 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 158878002699 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 158878002700 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 158878002701 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 158878002702 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 158878002703 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 158878002704 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 158878002705 Kinase associated protein B; Region: KapB; pfam08810 158878002706 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 158878002707 active site 158878002708 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 158878002709 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 158878002710 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 158878002711 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 158878002712 putative active site [active] 158878002713 putative FMN binding site [chemical binding]; other site 158878002714 putative substrate binding site [chemical binding]; other site 158878002715 putative catalytic residue [active] 158878002716 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 158878002717 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 158878002718 inhibitor-cofactor binding pocket; inhibition site 158878002719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878002720 catalytic residue [active] 158878002721 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 158878002722 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 158878002723 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 158878002724 NAD(P) binding site [chemical binding]; other site 158878002725 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 158878002726 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 158878002727 active site 158878002728 catalytic site [active] 158878002729 metal binding site [ion binding]; metal-binding site 158878002730 argininosuccinate lyase; Provisional; Region: PRK00855 158878002731 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 158878002732 active sites [active] 158878002733 tetramer interface [polypeptide binding]; other site 158878002734 argininosuccinate synthase; Provisional; Region: PRK13820 158878002735 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 158878002736 ANP binding site [chemical binding]; other site 158878002737 Substrate Binding Site II [chemical binding]; other site 158878002738 Substrate Binding Site I [chemical binding]; other site 158878002739 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 158878002740 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 158878002741 active site 158878002742 dimer interface [polypeptide binding]; other site 158878002743 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 158878002744 dimer interface [polypeptide binding]; other site 158878002745 active site 158878002746 Uncharacterized conserved protein [Function unknown]; Region: COG0398 158878002747 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 158878002748 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 158878002749 Catalytic site [active] 158878002750 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 158878002751 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 158878002752 Catalytic site [active] 158878002753 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 158878002754 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 158878002755 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 158878002756 Part of AAA domain; Region: AAA_19; pfam13245 158878002757 Family description; Region: UvrD_C_2; pfam13538 158878002758 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 158878002759 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 158878002760 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 158878002761 hypothetical protein; Provisional; Region: PRK13673 158878002762 coenzyme A disulfide reductase; Provisional; Region: PRK13512 158878002763 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158878002764 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158878002765 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 158878002766 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 158878002767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878002768 active site 158878002769 motif I; other site 158878002770 motif II; other site 158878002771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878002772 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 158878002773 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 158878002774 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 158878002775 catalytic triad [active] 158878002776 catalytic triad [active] 158878002777 oxyanion hole [active] 158878002778 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 158878002779 Clp amino terminal domain; Region: Clp_N; pfam02861 158878002780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878002781 Walker A motif; other site 158878002782 ATP binding site [chemical binding]; other site 158878002783 Walker B motif; other site 158878002784 arginine finger; other site 158878002785 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 158878002786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878002787 Walker A motif; other site 158878002788 ATP binding site [chemical binding]; other site 158878002789 Walker B motif; other site 158878002790 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 158878002791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 158878002792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 158878002793 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 158878002794 dimerization interface [polypeptide binding]; other site 158878002795 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 158878002796 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 158878002797 active site 158878002798 catalytic residues [active] 158878002799 metal binding site [ion binding]; metal-binding site 158878002800 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 158878002801 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 158878002802 substrate binding site [chemical binding]; other site 158878002803 MAP domain; Region: MAP; pfam03642 158878002804 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 158878002805 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 158878002806 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 158878002807 dimer interface [polypeptide binding]; other site 158878002808 active site 158878002809 CoA binding pocket [chemical binding]; other site 158878002810 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 158878002811 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 158878002812 dimer interface [polypeptide binding]; other site 158878002813 active site 158878002814 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 158878002815 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 158878002816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878002817 dimer interface [polypeptide binding]; other site 158878002818 conserved gate region; other site 158878002819 putative PBP binding loops; other site 158878002820 ABC-ATPase subunit interface; other site 158878002821 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 158878002822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878002823 dimer interface [polypeptide binding]; other site 158878002824 conserved gate region; other site 158878002825 putative PBP binding loops; other site 158878002826 ABC-ATPase subunit interface; other site 158878002827 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 158878002828 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158878002829 Walker A/P-loop; other site 158878002830 ATP binding site [chemical binding]; other site 158878002831 Q-loop/lid; other site 158878002832 ABC transporter signature motif; other site 158878002833 Walker B; other site 158878002834 D-loop; other site 158878002835 H-loop/switch region; other site 158878002836 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 158878002837 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 158878002838 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158878002839 Walker A/P-loop; other site 158878002840 ATP binding site [chemical binding]; other site 158878002841 Q-loop/lid; other site 158878002842 ABC transporter signature motif; other site 158878002843 Walker B; other site 158878002844 D-loop; other site 158878002845 H-loop/switch region; other site 158878002846 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 158878002847 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 158878002848 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 158878002849 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 158878002850 peptide binding site [polypeptide binding]; other site 158878002851 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 158878002852 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 158878002853 peptide binding site [polypeptide binding]; other site 158878002854 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 158878002855 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158878002856 Walker A/P-loop; other site 158878002857 ATP binding site [chemical binding]; other site 158878002858 Q-loop/lid; other site 158878002859 ABC transporter signature motif; other site 158878002860 Walker B; other site 158878002861 D-loop; other site 158878002862 H-loop/switch region; other site 158878002863 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 158878002864 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 158878002865 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158878002866 Walker A/P-loop; other site 158878002867 ATP binding site [chemical binding]; other site 158878002868 Q-loop/lid; other site 158878002869 ABC transporter signature motif; other site 158878002870 Walker B; other site 158878002871 D-loop; other site 158878002872 H-loop/switch region; other site 158878002873 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 158878002874 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 158878002875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878002876 dimer interface [polypeptide binding]; other site 158878002877 conserved gate region; other site 158878002878 putative PBP binding loops; other site 158878002879 ABC-ATPase subunit interface; other site 158878002880 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 158878002881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878002882 dimer interface [polypeptide binding]; other site 158878002883 conserved gate region; other site 158878002884 putative PBP binding loops; other site 158878002885 ABC-ATPase subunit interface; other site 158878002886 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 158878002887 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 158878002888 active site 158878002889 HIGH motif; other site 158878002890 dimer interface [polypeptide binding]; other site 158878002891 KMSKS motif; other site 158878002892 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 158878002893 ArsC family; Region: ArsC; pfam03960 158878002894 putative catalytic residues [active] 158878002895 thiol/disulfide switch; other site 158878002896 adaptor protein; Provisional; Region: PRK02315 158878002897 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 158878002898 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 158878002899 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 158878002900 active site 158878002901 Zn binding site [ion binding]; other site 158878002902 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 158878002903 Thioredoxin; Region: Thioredoxin_5; pfam13743 158878002904 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 158878002905 apolar tunnel; other site 158878002906 heme binding site [chemical binding]; other site 158878002907 dimerization interface [polypeptide binding]; other site 158878002908 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 158878002909 putative active site [active] 158878002910 putative metal binding residues [ion binding]; other site 158878002911 signature motif; other site 158878002912 putative triphosphate binding site [ion binding]; other site 158878002913 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 158878002914 synthetase active site [active] 158878002915 NTP binding site [chemical binding]; other site 158878002916 metal binding site [ion binding]; metal-binding site 158878002917 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 158878002918 ATP-NAD kinase; Region: NAD_kinase; pfam01513 158878002919 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 158878002920 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 158878002921 active site 158878002922 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 158878002923 MgtE intracellular N domain; Region: MgtE_N; smart00924 158878002924 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 158878002925 Divalent cation transporter; Region: MgtE; pfam01769 158878002926 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 158878002927 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 158878002928 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 158878002929 TrkA-N domain; Region: TrkA_N; pfam02254 158878002930 TrkA-C domain; Region: TrkA_C; pfam02080 158878002931 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 158878002932 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 158878002933 NAD binding site [chemical binding]; other site 158878002934 homotetramer interface [polypeptide binding]; other site 158878002935 homodimer interface [polypeptide binding]; other site 158878002936 substrate binding site [chemical binding]; other site 158878002937 active site 158878002938 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 158878002939 Domain of unknown function DUF20; Region: UPF0118; pfam01594 158878002940 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 158878002941 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 158878002942 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 158878002943 Putative esterase; Region: Esterase; pfam00756 158878002944 hypothetical protein; Provisional; Region: PRK13679 158878002945 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 158878002946 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158878002947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878002948 putative substrate translocation pore; other site 158878002949 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 158878002950 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 158878002951 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 158878002952 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 158878002953 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 158878002954 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 158878002955 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 158878002956 YueH-like protein; Region: YueH; pfam14166 158878002957 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 158878002958 G1 box; other site 158878002959 GTP/Mg2+ binding site [chemical binding]; other site 158878002960 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 158878002961 G4 box; other site 158878002962 G5 box; other site 158878002963 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 158878002964 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 158878002965 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 158878002966 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 158878002967 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 158878002968 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 158878002969 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 158878002970 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 158878002971 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158878002972 active site 158878002973 metal binding site [ion binding]; metal-binding site 158878002974 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 158878002975 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 158878002976 IDEAL domain; Region: IDEAL; pfam08858 158878002977 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 158878002978 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 158878002979 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 158878002980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 158878002981 CAAX protease self-immunity; Region: Abi; pfam02517 158878002982 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 158878002983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 158878002984 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 158878002985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 158878002986 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158878002987 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 158878002988 Walker A/P-loop; other site 158878002989 ATP binding site [chemical binding]; other site 158878002990 Q-loop/lid; other site 158878002991 ABC transporter signature motif; other site 158878002992 Walker B; other site 158878002993 D-loop; other site 158878002994 H-loop/switch region; other site 158878002995 Predicted membrane protein [Function unknown]; Region: COG2259 158878002996 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 158878002997 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 158878002998 siderophore binding site; other site 158878002999 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 158878003000 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878003001 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158878003002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158878003003 Coenzyme A binding pocket [chemical binding]; other site 158878003004 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 158878003005 UbiA prenyltransferase family; Region: UbiA; pfam01040 158878003006 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 158878003007 isochorismate synthases; Region: isochor_syn; TIGR00543 158878003008 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 158878003009 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 158878003010 dimer interface [polypeptide binding]; other site 158878003011 tetramer interface [polypeptide binding]; other site 158878003012 PYR/PP interface [polypeptide binding]; other site 158878003013 TPP binding site [chemical binding]; other site 158878003014 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 158878003015 TPP-binding site; other site 158878003016 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 158878003017 PGAP1-like protein; Region: PGAP1; pfam07819 158878003018 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 158878003019 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 158878003020 substrate binding site [chemical binding]; other site 158878003021 oxyanion hole (OAH) forming residues; other site 158878003022 trimer interface [polypeptide binding]; other site 158878003023 Staphostatin B; Region: Staphostatin_B; pfam09023 158878003024 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 158878003025 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 158878003026 aminotransferase A; Validated; Region: PRK07683 158878003027 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158878003028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878003029 homodimer interface [polypeptide binding]; other site 158878003030 catalytic residue [active] 158878003031 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 158878003032 Acyltransferase family; Region: Acyl_transf_3; pfam01757 158878003033 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 158878003034 MarR family; Region: MarR; pfam01047 158878003035 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 158878003036 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 158878003037 amidase catalytic site [active] 158878003038 Zn binding residues [ion binding]; other site 158878003039 substrate binding site [chemical binding]; other site 158878003040 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 158878003041 Lysozyme subfamily 2; Region: LYZ2; smart00047 158878003042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878003043 Coenzyme A binding pocket [chemical binding]; other site 158878003044 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 158878003045 Transcriptional regulator [Transcription]; Region: LytR; COG1316 158878003046 Beta-lactamase; Region: Beta-lactamase; pfam00144 158878003047 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 158878003048 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 158878003049 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 158878003050 Subunit I/III interface [polypeptide binding]; other site 158878003051 Subunit III/IV interface [polypeptide binding]; other site 158878003052 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 158878003053 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 158878003054 D-pathway; other site 158878003055 Putative ubiquinol binding site [chemical binding]; other site 158878003056 Low-spin heme (heme b) binding site [chemical binding]; other site 158878003057 Putative water exit pathway; other site 158878003058 Binuclear center (heme o3/CuB) [ion binding]; other site 158878003059 K-pathway; other site 158878003060 Putative proton exit pathway; other site 158878003061 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 158878003062 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 158878003063 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 158878003064 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 158878003065 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 158878003066 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 158878003067 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 158878003068 homodimer interface [polypeptide binding]; other site 158878003069 NADP binding site [chemical binding]; other site 158878003070 substrate binding site [chemical binding]; other site 158878003071 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 158878003072 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 158878003073 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 158878003074 NAD binding site [chemical binding]; other site 158878003075 ATP-grasp domain; Region: ATP-grasp; pfam02222 158878003076 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 158878003077 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 158878003078 ATP binding site [chemical binding]; other site 158878003079 active site 158878003080 substrate binding site [chemical binding]; other site 158878003081 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 158878003082 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 158878003083 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 158878003084 putative active site [active] 158878003085 catalytic triad [active] 158878003086 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 158878003087 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 158878003088 dimerization interface [polypeptide binding]; other site 158878003089 ATP binding site [chemical binding]; other site 158878003090 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 158878003091 dimerization interface [polypeptide binding]; other site 158878003092 ATP binding site [chemical binding]; other site 158878003093 amidophosphoribosyltransferase; Provisional; Region: PRK07272 158878003094 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 158878003095 active site 158878003096 tetramer interface [polypeptide binding]; other site 158878003097 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158878003098 active site 158878003099 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 158878003100 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 158878003101 dimerization interface [polypeptide binding]; other site 158878003102 putative ATP binding site [chemical binding]; other site 158878003103 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 158878003104 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 158878003105 active site 158878003106 substrate binding site [chemical binding]; other site 158878003107 cosubstrate binding site; other site 158878003108 catalytic site [active] 158878003109 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 158878003110 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 158878003111 purine monophosphate binding site [chemical binding]; other site 158878003112 dimer interface [polypeptide binding]; other site 158878003113 putative catalytic residues [active] 158878003114 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 158878003115 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 158878003116 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 158878003117 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 158878003118 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 158878003119 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 158878003120 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 158878003121 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 158878003122 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158878003123 Walker A/P-loop; other site 158878003124 ATP binding site [chemical binding]; other site 158878003125 Q-loop/lid; other site 158878003126 ABC transporter signature motif; other site 158878003127 Walker B; other site 158878003128 D-loop; other site 158878003129 H-loop/switch region; other site 158878003130 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 158878003131 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158878003132 Walker A/P-loop; other site 158878003133 ATP binding site [chemical binding]; other site 158878003134 Q-loop/lid; other site 158878003135 ABC transporter signature motif; other site 158878003136 Walker B; other site 158878003137 D-loop; other site 158878003138 H-loop/switch region; other site 158878003139 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 158878003140 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 158878003141 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 158878003142 putative RNA binding site [nucleotide binding]; other site 158878003143 Methyltransferase domain; Region: Methyltransf_26; pfam13659 158878003144 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 158878003145 dimerization domain swap beta strand [polypeptide binding]; other site 158878003146 regulatory protein interface [polypeptide binding]; other site 158878003147 active site 158878003148 regulatory phosphorylation site [posttranslational modification]; other site 158878003149 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 158878003150 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 158878003151 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 158878003152 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 158878003153 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 158878003154 catalytic residues [active] 158878003155 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 158878003156 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 158878003157 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 158878003158 TrkA-N domain; Region: TrkA_N; pfam02254 158878003159 TrkA-C domain; Region: TrkA_C; pfam02080 158878003160 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 158878003161 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 158878003162 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 158878003163 hypothetical protein; Provisional; Region: PRK13667 158878003164 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 158878003165 active site 158878003166 catalytic residues [active] 158878003167 metal binding site [ion binding]; metal-binding site 158878003168 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 158878003169 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 158878003170 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 158878003171 TPP-binding site [chemical binding]; other site 158878003172 tetramer interface [polypeptide binding]; other site 158878003173 heterodimer interface [polypeptide binding]; other site 158878003174 phosphorylation loop region [posttranslational modification] 158878003175 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 158878003176 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 158878003177 alpha subunit interface [polypeptide binding]; other site 158878003178 TPP binding site [chemical binding]; other site 158878003179 heterodimer interface [polypeptide binding]; other site 158878003180 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158878003181 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 158878003182 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 158878003183 E3 interaction surface; other site 158878003184 lipoyl attachment site [posttranslational modification]; other site 158878003185 e3 binding domain; Region: E3_binding; pfam02817 158878003186 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 158878003187 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 158878003188 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158878003189 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158878003190 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 158878003191 hypothetical protein; Provisional; Region: PRK04387 158878003192 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158878003193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878003194 non-specific DNA binding site [nucleotide binding]; other site 158878003195 salt bridge; other site 158878003196 sequence-specific DNA binding site [nucleotide binding]; other site 158878003197 Cupin domain; Region: Cupin_2; pfam07883 158878003198 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158878003199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158878003200 Walker A/P-loop; other site 158878003201 ATP binding site [chemical binding]; other site 158878003202 Q-loop/lid; other site 158878003203 ABC transporter signature motif; other site 158878003204 Walker B; other site 158878003205 D-loop; other site 158878003206 H-loop/switch region; other site 158878003207 TOBE domain; Region: TOBE_2; pfam08402 158878003208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878003209 putative PBP binding loops; other site 158878003210 dimer interface [polypeptide binding]; other site 158878003211 ABC-ATPase subunit interface; other site 158878003212 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158878003213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878003214 dimer interface [polypeptide binding]; other site 158878003215 conserved gate region; other site 158878003216 putative PBP binding loops; other site 158878003217 ABC-ATPase subunit interface; other site 158878003218 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 158878003219 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 158878003220 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158878003221 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 158878003222 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 158878003223 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 158878003224 manganese transport protein MntH; Reviewed; Region: PRK00701 158878003225 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 158878003226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 158878003227 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 158878003228 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 158878003229 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 158878003230 active site 158878003231 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 158878003232 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 158878003233 G1 box; other site 158878003234 putative GEF interaction site [polypeptide binding]; other site 158878003235 GTP/Mg2+ binding site [chemical binding]; other site 158878003236 Switch I region; other site 158878003237 G2 box; other site 158878003238 G3 box; other site 158878003239 Switch II region; other site 158878003240 G4 box; other site 158878003241 G5 box; other site 158878003242 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 158878003243 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 158878003244 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 158878003245 hypothetical protein; Provisional; Region: PRK13666 158878003246 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 158878003247 pyruvate carboxylase; Reviewed; Region: PRK12999 158878003248 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 158878003249 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 158878003250 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 158878003251 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 158878003252 active site 158878003253 catalytic residues [active] 158878003254 metal binding site [ion binding]; metal-binding site 158878003255 homodimer binding site [polypeptide binding]; other site 158878003256 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 158878003257 carboxyltransferase (CT) interaction site; other site 158878003258 biotinylation site [posttranslational modification]; other site 158878003259 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 158878003260 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 158878003261 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 158878003262 UbiA prenyltransferase family; Region: UbiA; pfam01040 158878003263 Predicted membrane protein [Function unknown]; Region: COG2322 158878003264 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 158878003265 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 158878003266 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 158878003267 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 158878003268 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 158878003269 putative active site [active] 158878003270 catalytic site [active] 158878003271 putative metal binding site [ion binding]; other site 158878003272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 158878003273 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 158878003274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878003275 S-adenosylmethionine binding site [chemical binding]; other site 158878003276 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 158878003277 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 158878003278 active site 158878003279 (T/H)XGH motif; other site 158878003280 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 158878003281 hypothetical protein; Provisional; Region: PRK13670 158878003282 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 158878003283 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 158878003284 heme uptake protein IsdB; Region: IsdB; TIGR03657 158878003285 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 158878003286 NEAr Transporter domain; Region: NEAT; smart00725 158878003287 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 158878003288 heme-binding site [chemical binding]; other site 158878003289 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 158878003290 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 158878003291 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 158878003292 heme-binding site [chemical binding]; other site 158878003293 heme uptake protein IsdC; Region: IsdC; TIGR03656 158878003294 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 158878003295 heme-binding site [chemical binding]; other site 158878003296 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 158878003297 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 158878003298 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 158878003299 intersubunit interface [polypeptide binding]; other site 158878003300 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 158878003301 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158878003302 ABC-ATPase subunit interface; other site 158878003303 dimer interface [polypeptide binding]; other site 158878003304 putative PBP binding regions; other site 158878003305 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 158878003306 active site 158878003307 catalytic site [active] 158878003308 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 158878003309 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 158878003310 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 158878003311 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 158878003312 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 158878003313 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 158878003314 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 158878003315 dimer interface [polypeptide binding]; other site 158878003316 motif 1; other site 158878003317 active site 158878003318 motif 2; other site 158878003319 motif 3; other site 158878003320 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 158878003321 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 158878003322 putative tRNA-binding site [nucleotide binding]; other site 158878003323 B3/4 domain; Region: B3_4; pfam03483 158878003324 tRNA synthetase B5 domain; Region: B5; smart00874 158878003325 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 158878003326 dimer interface [polypeptide binding]; other site 158878003327 motif 1; other site 158878003328 motif 3; other site 158878003329 motif 2; other site 158878003330 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 158878003331 ribonuclease HIII; Provisional; Region: PRK00996 158878003332 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 158878003333 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 158878003334 RNA/DNA hybrid binding site [nucleotide binding]; other site 158878003335 active site 158878003336 Cell division protein ZapA; Region: ZapA; cl01146 158878003337 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 158878003338 Colicin V production protein; Region: Colicin_V; pfam02674 158878003339 hypothetical protein; Provisional; Region: PRK08609 158878003340 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 158878003341 active site 158878003342 primer binding site [nucleotide binding]; other site 158878003343 NTP binding site [chemical binding]; other site 158878003344 metal binding triad [ion binding]; metal-binding site 158878003345 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 158878003346 active site 158878003347 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 158878003348 MutS domain III; Region: MutS_III; pfam05192 158878003349 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 158878003350 Walker A/P-loop; other site 158878003351 ATP binding site [chemical binding]; other site 158878003352 Q-loop/lid; other site 158878003353 ABC transporter signature motif; other site 158878003354 Walker B; other site 158878003355 D-loop; other site 158878003356 H-loop/switch region; other site 158878003357 Smr domain; Region: Smr; pfam01713 158878003358 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 158878003359 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 158878003360 catalytic residues [active] 158878003361 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 158878003362 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 158878003363 GIY-YIG motif/motif A; other site 158878003364 active site 158878003365 catalytic site [active] 158878003366 putative DNA binding site [nucleotide binding]; other site 158878003367 metal binding site [ion binding]; metal-binding site 158878003368 UvrB/uvrC motif; Region: UVR; pfam02151 158878003369 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 158878003370 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 158878003371 putative Iron-sulfur protein interface [polypeptide binding]; other site 158878003372 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 158878003373 proximal heme binding site [chemical binding]; other site 158878003374 distal heme binding site [chemical binding]; other site 158878003375 putative dimer interface [polypeptide binding]; other site 158878003376 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 158878003377 L-aspartate oxidase; Provisional; Region: PRK06175 158878003378 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 158878003379 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 158878003380 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 158878003381 glutamate racemase; Provisional; Region: PRK00865 158878003382 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 158878003383 active site 158878003384 dimerization interface [polypeptide binding]; other site 158878003385 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 158878003386 active site 158878003387 metal binding site [ion binding]; metal-binding site 158878003388 homotetramer interface [polypeptide binding]; other site 158878003389 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 158878003390 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 158878003391 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 158878003392 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 158878003393 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 158878003394 Transposase; Region: DDE_Tnp_ISL3; pfam01610 158878003395 beta-channel forming cytolysin; Region: hlyII; TIGR01002 158878003396 superantigen-like protein; Reviewed; Region: PRK13350 158878003397 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878003398 superantigen-like protein; Reviewed; Region: PRK13349 158878003399 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878003400 superantigen-like protein; Reviewed; Region: PRK13043 158878003401 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878003402 ornithine carbamoyltransferase; Provisional; Region: PRK04284 158878003403 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 158878003404 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 158878003405 carbamate kinase; Reviewed; Region: PRK12686 158878003406 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 158878003407 putative substrate binding site [chemical binding]; other site 158878003408 nucleotide binding site [chemical binding]; other site 158878003409 nucleotide binding site [chemical binding]; other site 158878003410 homodimer interface [polypeptide binding]; other site 158878003411 Predicted membrane protein [Function unknown]; Region: COG1288 158878003412 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 158878003413 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 158878003414 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 158878003415 gating phenylalanine in ion channel; other site 158878003416 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 158878003417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878003418 motif II; other site 158878003419 hypothetical protein; Provisional; Region: PRK13688 158878003420 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 158878003421 Coenzyme A binding pocket [chemical binding]; other site 158878003422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 158878003423 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 158878003424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 158878003425 MraZ protein; Region: MraZ; pfam02381 158878003426 MraZ protein; Region: MraZ; pfam02381 158878003427 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 158878003428 MraW methylase family; Region: Methyltransf_5; pfam01795 158878003429 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 158878003430 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 158878003431 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 158878003432 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 158878003433 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 158878003434 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 158878003435 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 158878003436 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 158878003437 Mg++ binding site [ion binding]; other site 158878003438 putative catalytic motif [active] 158878003439 putative substrate binding site [chemical binding]; other site 158878003440 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 158878003441 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 158878003442 NAD binding site [chemical binding]; other site 158878003443 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 158878003444 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 158878003445 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 158878003446 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 158878003447 Cell division protein FtsQ; Region: FtsQ; pfam03799 158878003448 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 158878003449 Cell division protein FtsA; Region: FtsA; smart00842 158878003450 Cell division protein FtsA; Region: FtsA; pfam14450 158878003451 cell division protein FtsZ; Validated; Region: PRK09330 158878003452 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 158878003453 nucleotide binding site [chemical binding]; other site 158878003454 SulA interaction site; other site 158878003455 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 158878003456 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 158878003457 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 158878003458 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158878003459 catalytic residue [active] 158878003460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 158878003461 YGGT family; Region: YGGT; pfam02325 158878003462 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 158878003463 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 158878003464 RNA binding surface [nucleotide binding]; other site 158878003465 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 158878003466 DivIVA domain; Region: DivI1A_domain; TIGR03544 158878003467 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 158878003468 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 158878003469 HIGH motif; other site 158878003470 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 158878003471 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 158878003472 active site 158878003473 KMSKS motif; other site 158878003474 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 158878003475 tRNA binding surface [nucleotide binding]; other site 158878003476 anticodon binding site; other site 158878003477 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 158878003478 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 158878003479 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 158878003480 active site 158878003481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 158878003482 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 158878003483 lipoprotein signal peptidase; Provisional; Region: PRK14787 158878003484 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 158878003485 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 158878003486 RNA binding surface [nucleotide binding]; other site 158878003487 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 158878003488 active site 158878003489 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 158878003490 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 158878003491 uracil transporter; Provisional; Region: PRK10720 158878003492 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 158878003493 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 158878003494 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 158878003495 dihydroorotase; Validated; Region: pyrC; PRK09357 158878003496 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158878003497 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 158878003498 active site 158878003499 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 158878003500 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 158878003501 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 158878003502 catalytic site [active] 158878003503 subunit interface [polypeptide binding]; other site 158878003504 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 158878003505 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 158878003506 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 158878003507 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 158878003508 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 158878003509 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158878003510 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 158878003511 IMP binding site; other site 158878003512 dimer interface [polypeptide binding]; other site 158878003513 interdomain contacts; other site 158878003514 partial ornithine binding site; other site 158878003515 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 158878003516 active site 158878003517 dimer interface [polypeptide binding]; other site 158878003518 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158878003519 active site 158878003520 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 158878003521 dimer interface [polypeptide binding]; other site 158878003522 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 158878003523 Domain of unknown function (DUF814); Region: DUF814; pfam05670 158878003524 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 158878003525 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 158878003526 catalytic site [active] 158878003527 G-X2-G-X-G-K; other site 158878003528 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 158878003529 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 158878003530 Flavoprotein; Region: Flavoprotein; pfam02441 158878003531 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 158878003532 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 158878003533 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158878003534 ATP binding site [chemical binding]; other site 158878003535 putative Mg++ binding site [ion binding]; other site 158878003536 helicase superfamily c-terminal domain; Region: HELICc; smart00490 158878003537 nucleotide binding region [chemical binding]; other site 158878003538 ATP-binding site [chemical binding]; other site 158878003539 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 158878003540 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 158878003541 active site 158878003542 catalytic residues [active] 158878003543 metal binding site [ion binding]; metal-binding site 158878003544 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 158878003545 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 158878003546 putative active site [active] 158878003547 substrate binding site [chemical binding]; other site 158878003548 putative cosubstrate binding site; other site 158878003549 catalytic site [active] 158878003550 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 158878003551 substrate binding site [chemical binding]; other site 158878003552 16S rRNA methyltransferase B; Provisional; Region: PRK14902 158878003553 NusB family; Region: NusB; pfam01029 158878003554 putative RNA binding site [nucleotide binding]; other site 158878003555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878003556 S-adenosylmethionine binding site [chemical binding]; other site 158878003557 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 158878003558 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158878003559 FeS/SAM binding site; other site 158878003560 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 158878003561 Protein phosphatase 2C; Region: PP2C; pfam00481 158878003562 active site 158878003563 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 158878003564 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 158878003565 active site 158878003566 ATP binding site [chemical binding]; other site 158878003567 substrate binding site [chemical binding]; other site 158878003568 activation loop (A-loop); other site 158878003569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 158878003570 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 158878003571 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 158878003572 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 158878003573 Predicted GTPases [General function prediction only]; Region: COG1162 158878003574 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 158878003575 RNA binding site [nucleotide binding]; other site 158878003576 homodimer interface [polypeptide binding]; other site 158878003577 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 158878003578 GTPase/Zn-binding domain interface [polypeptide binding]; other site 158878003579 GTP/Mg2+ binding site [chemical binding]; other site 158878003580 G4 box; other site 158878003581 G5 box; other site 158878003582 G1 box; other site 158878003583 Switch I region; other site 158878003584 G2 box; other site 158878003585 G3 box; other site 158878003586 Switch II region; other site 158878003587 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 158878003588 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 158878003589 substrate binding site [chemical binding]; other site 158878003590 hexamer interface [polypeptide binding]; other site 158878003591 metal binding site [ion binding]; metal-binding site 158878003592 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 158878003593 Thiamine pyrophosphokinase; Region: TPK; cd07995 158878003594 active site 158878003595 dimerization interface [polypeptide binding]; other site 158878003596 thiamine binding site [chemical binding]; other site 158878003597 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 158878003598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 158878003599 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 158878003600 DAK2 domain; Region: Dak2; pfam02734 158878003601 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 158878003602 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 158878003603 generic binding surface II; other site 158878003604 ssDNA binding site; other site 158878003605 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158878003606 ATP binding site [chemical binding]; other site 158878003607 putative Mg++ binding site [ion binding]; other site 158878003608 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158878003609 nucleotide binding region [chemical binding]; other site 158878003610 ATP-binding site [chemical binding]; other site 158878003611 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 158878003612 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 158878003613 active site 2 [active] 158878003614 active site 1 [active] 158878003615 putative phosphate acyltransferase; Provisional; Region: PRK05331 158878003616 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 158878003617 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 158878003618 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 158878003619 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 158878003620 NAD(P) binding site [chemical binding]; other site 158878003621 homotetramer interface [polypeptide binding]; other site 158878003622 homodimer interface [polypeptide binding]; other site 158878003623 active site 158878003624 acyl carrier protein; Provisional; Region: acpP; PRK00982 158878003625 ribonuclease III; Reviewed; Region: rnc; PRK00102 158878003626 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 158878003627 dimerization interface [polypeptide binding]; other site 158878003628 active site 158878003629 metal binding site [ion binding]; metal-binding site 158878003630 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 158878003631 dsRNA binding site [nucleotide binding]; other site 158878003632 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 158878003633 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 158878003634 Walker A/P-loop; other site 158878003635 ATP binding site [chemical binding]; other site 158878003636 Q-loop/lid; other site 158878003637 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 158878003638 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 158878003639 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 158878003640 ABC transporter signature motif; other site 158878003641 Walker B; other site 158878003642 D-loop; other site 158878003643 H-loop/switch region; other site 158878003644 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 158878003645 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 158878003646 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 158878003647 P loop; other site 158878003648 GTP binding site [chemical binding]; other site 158878003649 putative DNA-binding protein; Validated; Region: PRK00118 158878003650 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 158878003651 signal recognition particle protein; Provisional; Region: PRK10867 158878003652 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 158878003653 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 158878003654 P loop; other site 158878003655 GTP binding site [chemical binding]; other site 158878003656 Signal peptide binding domain; Region: SRP_SPB; pfam02978 158878003657 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 158878003658 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 158878003659 RimM N-terminal domain; Region: RimM; pfam01782 158878003660 PRC-barrel domain; Region: PRC; pfam05239 158878003661 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 158878003662 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 158878003663 Predicted membrane protein [Function unknown]; Region: COG4485 158878003664 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 158878003665 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 158878003666 GTP/Mg2+ binding site [chemical binding]; other site 158878003667 G4 box; other site 158878003668 G5 box; other site 158878003669 G1 box; other site 158878003670 Switch I region; other site 158878003671 G2 box; other site 158878003672 G3 box; other site 158878003673 Switch II region; other site 158878003674 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 158878003675 RNA/DNA hybrid binding site [nucleotide binding]; other site 158878003676 active site 158878003677 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 158878003678 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 158878003679 CoA-ligase; Region: Ligase_CoA; pfam00549 158878003680 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 158878003681 CoA binding domain; Region: CoA_binding; pfam02629 158878003682 CoA-ligase; Region: Ligase_CoA; pfam00549 158878003683 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 158878003684 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 158878003685 CHAP domain; Region: CHAP; pfam05257 158878003686 FemAB family; Region: FemAB; pfam02388 158878003687 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 158878003688 DNA protecting protein DprA; Region: dprA; TIGR00732 158878003689 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 158878003690 DNA topoisomerase I; Validated; Region: PRK05582 158878003691 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 158878003692 active site 158878003693 interdomain interaction site; other site 158878003694 putative metal-binding site [ion binding]; other site 158878003695 nucleotide binding site [chemical binding]; other site 158878003696 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 158878003697 domain I; other site 158878003698 DNA binding groove [nucleotide binding] 158878003699 phosphate binding site [ion binding]; other site 158878003700 domain II; other site 158878003701 domain III; other site 158878003702 nucleotide binding site [chemical binding]; other site 158878003703 catalytic site [active] 158878003704 domain IV; other site 158878003705 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 158878003706 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 158878003707 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 158878003708 Glucose inhibited division protein A; Region: GIDA; pfam01134 158878003709 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 158878003710 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158878003711 active site 158878003712 DNA binding site [nucleotide binding] 158878003713 Int/Topo IB signature motif; other site 158878003714 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 158878003715 active site 158878003716 HslU subunit interaction site [polypeptide binding]; other site 158878003717 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 158878003718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878003719 Walker A motif; other site 158878003720 ATP binding site [chemical binding]; other site 158878003721 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 158878003722 Walker B motif; other site 158878003723 arginine finger; other site 158878003724 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 158878003725 transcriptional repressor CodY; Validated; Region: PRK04158 158878003726 CodY GAF-like domain; Region: CodY; pfam06018 158878003727 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 158878003728 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 158878003729 rRNA interaction site [nucleotide binding]; other site 158878003730 S8 interaction site; other site 158878003731 putative laminin-1 binding site; other site 158878003732 elongation factor Ts; Provisional; Region: tsf; PRK09377 158878003733 UBA/TS-N domain; Region: UBA; pfam00627 158878003734 Elongation factor TS; Region: EF_TS; pfam00889 158878003735 Elongation factor TS; Region: EF_TS; pfam00889 158878003736 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 158878003737 putative nucleotide binding site [chemical binding]; other site 158878003738 uridine monophosphate binding site [chemical binding]; other site 158878003739 homohexameric interface [polypeptide binding]; other site 158878003740 ribosome recycling factor; Reviewed; Region: frr; PRK00083 158878003741 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 158878003742 hinge region; other site 158878003743 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 158878003744 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 158878003745 catalytic residue [active] 158878003746 putative FPP diphosphate binding site; other site 158878003747 putative FPP binding hydrophobic cleft; other site 158878003748 dimer interface [polypeptide binding]; other site 158878003749 putative IPP diphosphate binding site; other site 158878003750 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 158878003751 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 158878003752 RIP metalloprotease RseP; Region: TIGR00054 158878003753 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 158878003754 active site 158878003755 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 158878003756 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 158878003757 protein binding site [polypeptide binding]; other site 158878003758 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 158878003759 putative substrate binding region [chemical binding]; other site 158878003760 prolyl-tRNA synthetase; Provisional; Region: PRK09194 158878003761 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 158878003762 dimer interface [polypeptide binding]; other site 158878003763 motif 1; other site 158878003764 active site 158878003765 motif 2; other site 158878003766 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 158878003767 putative deacylase active site [active] 158878003768 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 158878003769 active site 158878003770 motif 3; other site 158878003771 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 158878003772 anticodon binding site; other site 158878003773 DNA polymerase III PolC; Validated; Region: polC; PRK00448 158878003774 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 158878003775 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 158878003776 generic binding surface II; other site 158878003777 generic binding surface I; other site 158878003778 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 158878003779 active site 158878003780 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 158878003781 active site 158878003782 catalytic site [active] 158878003783 substrate binding site [chemical binding]; other site 158878003784 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 158878003785 ribosome maturation protein RimP; Reviewed; Region: PRK00092 158878003786 Sm and related proteins; Region: Sm_like; cl00259 158878003787 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 158878003788 putative oligomer interface [polypeptide binding]; other site 158878003789 putative RNA binding site [nucleotide binding]; other site 158878003790 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 158878003791 NusA N-terminal domain; Region: NusA_N; pfam08529 158878003792 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 158878003793 RNA binding site [nucleotide binding]; other site 158878003794 homodimer interface [polypeptide binding]; other site 158878003795 NusA-like KH domain; Region: KH_5; pfam13184 158878003796 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 158878003797 G-X-X-G motif; other site 158878003798 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 158878003799 putative RNA binding cleft [nucleotide binding]; other site 158878003800 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 158878003801 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 158878003802 translation initiation factor IF-2; Region: IF-2; TIGR00487 158878003803 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 158878003804 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 158878003805 G1 box; other site 158878003806 putative GEF interaction site [polypeptide binding]; other site 158878003807 GTP/Mg2+ binding site [chemical binding]; other site 158878003808 Switch I region; other site 158878003809 G2 box; other site 158878003810 G3 box; other site 158878003811 Switch II region; other site 158878003812 G4 box; other site 158878003813 G5 box; other site 158878003814 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 158878003815 Translation-initiation factor 2; Region: IF-2; pfam11987 158878003816 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 158878003817 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 158878003818 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 158878003819 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 158878003820 RNA binding site [nucleotide binding]; other site 158878003821 active site 158878003822 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 158878003823 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 158878003824 active site 158878003825 Riboflavin kinase; Region: Flavokinase; smart00904 158878003826 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 158878003827 16S/18S rRNA binding site [nucleotide binding]; other site 158878003828 S13e-L30e interaction site [polypeptide binding]; other site 158878003829 25S rRNA binding site [nucleotide binding]; other site 158878003830 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 158878003831 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 158878003832 RNase E interface [polypeptide binding]; other site 158878003833 trimer interface [polypeptide binding]; other site 158878003834 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 158878003835 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 158878003836 RNase E interface [polypeptide binding]; other site 158878003837 trimer interface [polypeptide binding]; other site 158878003838 active site 158878003839 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 158878003840 putative nucleic acid binding region [nucleotide binding]; other site 158878003841 G-X-X-G motif; other site 158878003842 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 158878003843 RNA binding site [nucleotide binding]; other site 158878003844 domain interface; other site 158878003845 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 158878003846 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158878003847 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 158878003848 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 158878003849 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 158878003850 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 158878003851 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158878003852 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 158878003853 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 158878003854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 158878003855 DNA-binding site [nucleotide binding]; DNA binding site 158878003856 UTRA domain; Region: UTRA; pfam07702 158878003857 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 158878003858 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 158878003859 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 158878003860 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 158878003861 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 158878003862 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 158878003863 classical (c) SDRs; Region: SDR_c; cd05233 158878003864 NAD(P) binding site [chemical binding]; other site 158878003865 active site 158878003866 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 158878003867 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 158878003868 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 158878003869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878003870 non-specific DNA binding site [nucleotide binding]; other site 158878003871 salt bridge; other site 158878003872 sequence-specific DNA binding site [nucleotide binding]; other site 158878003873 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 158878003874 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 158878003875 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 158878003876 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 158878003877 putative MPT binding site; other site 158878003878 recombinase A; Provisional; Region: recA; PRK09354 158878003879 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 158878003880 hexamer interface [polypeptide binding]; other site 158878003881 Walker A motif; other site 158878003882 ATP binding site [chemical binding]; other site 158878003883 Walker B motif; other site 158878003884 phosphodiesterase; Provisional; Region: PRK12704 158878003885 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158878003886 Zn2+ binding site [ion binding]; other site 158878003887 Mg2+ binding site [ion binding]; other site 158878003888 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 158878003889 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158878003890 putative active site [active] 158878003891 metal binding site [ion binding]; metal-binding site 158878003892 homodimer binding site [polypeptide binding]; other site 158878003893 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 158878003894 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 158878003895 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 158878003896 dimer interface [polypeptide binding]; other site 158878003897 PYR/PP interface [polypeptide binding]; other site 158878003898 TPP binding site [chemical binding]; other site 158878003899 substrate binding site [chemical binding]; other site 158878003900 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 158878003901 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 158878003902 TPP-binding site [chemical binding]; other site 158878003903 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 158878003904 Uncharacterized conserved protein [Function unknown]; Region: COG0011 158878003905 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 158878003906 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 158878003907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158878003908 FeS/SAM binding site; other site 158878003909 TRAM domain; Region: TRAM; pfam01938 158878003910 Predicted membrane protein [Function unknown]; Region: COG4550 158878003911 Predicted membrane protein [Function unknown]; Region: COG4732 158878003912 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 158878003913 MutS domain I; Region: MutS_I; pfam01624 158878003914 MutS domain II; Region: MutS_II; pfam05188 158878003915 MutS domain III; Region: MutS_III; pfam05192 158878003916 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 158878003917 Walker A/P-loop; other site 158878003918 ATP binding site [chemical binding]; other site 158878003919 Q-loop/lid; other site 158878003920 ABC transporter signature motif; other site 158878003921 Walker B; other site 158878003922 D-loop; other site 158878003923 H-loop/switch region; other site 158878003924 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 158878003925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878003926 ATP binding site [chemical binding]; other site 158878003927 Mg2+ binding site [ion binding]; other site 158878003928 G-X-G motif; other site 158878003929 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 158878003930 ATP binding site [chemical binding]; other site 158878003931 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 158878003932 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 158878003933 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 158878003934 amphipathic channel; other site 158878003935 Asn-Pro-Ala signature motifs; other site 158878003936 glycerol kinase; Provisional; Region: glpK; PRK00047 158878003937 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 158878003938 N- and C-terminal domain interface [polypeptide binding]; other site 158878003939 active site 158878003940 MgATP binding site [chemical binding]; other site 158878003941 catalytic site [active] 158878003942 metal binding site [ion binding]; metal-binding site 158878003943 glycerol binding site [chemical binding]; other site 158878003944 homotetramer interface [polypeptide binding]; other site 158878003945 homodimer interface [polypeptide binding]; other site 158878003946 FBP binding site [chemical binding]; other site 158878003947 protein IIAGlc interface [polypeptide binding]; other site 158878003948 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 158878003949 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 158878003950 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 158878003951 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 158878003952 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 158878003953 bacterial Hfq-like; Region: Hfq; cd01716 158878003954 hexamer interface [polypeptide binding]; other site 158878003955 Sm1 motif; other site 158878003956 RNA binding site [nucleotide binding]; other site 158878003957 Sm2 motif; other site 158878003958 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 158878003959 catalytic residues [active] 158878003960 dimer interface [polypeptide binding]; other site 158878003961 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 158878003962 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 158878003963 HflX GTPase family; Region: HflX; cd01878 158878003964 G1 box; other site 158878003965 GTP/Mg2+ binding site [chemical binding]; other site 158878003966 Switch I region; other site 158878003967 G2 box; other site 158878003968 G3 box; other site 158878003969 Switch II region; other site 158878003970 G4 box; other site 158878003971 G5 box; other site 158878003972 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 158878003973 Aluminium resistance protein; Region: Alum_res; pfam06838 158878003974 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 158878003975 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 158878003976 DNA binding residues [nucleotide binding] 158878003977 putative dimer interface [polypeptide binding]; other site 158878003978 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 158878003979 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 158878003980 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 158878003981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 158878003982 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 158878003983 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158878003984 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158878003985 catalytic residue [active] 158878003986 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 158878003987 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 158878003988 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 158878003989 putative active site [active] 158878003990 catalytic site [active] 158878003991 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 158878003992 putative active site [active] 158878003993 catalytic site [active] 158878003994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158878003995 Walker A/P-loop; other site 158878003996 ATP binding site [chemical binding]; other site 158878003997 ABC transporter; Region: ABC_tran; pfam00005 158878003998 Q-loop/lid; other site 158878003999 ABC transporter signature motif; other site 158878004000 Walker B; other site 158878004001 D-loop; other site 158878004002 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 158878004003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 158878004004 Histidine kinase; Region: HisKA_3; pfam07730 158878004005 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 158878004006 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158878004007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878004008 active site 158878004009 phosphorylation site [posttranslational modification] 158878004010 intermolecular recognition site; other site 158878004011 dimerization interface [polypeptide binding]; other site 158878004012 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158878004013 DNA binding residues [nucleotide binding] 158878004014 dimerization interface [polypeptide binding]; other site 158878004015 Staphylococcal nuclease homologues; Region: SNc; smart00318 158878004016 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 158878004017 Catalytic site; other site 158878004018 AAA domain; Region: AAA_11; pfam13086 158878004019 aspartate kinase; Reviewed; Region: PRK09034 158878004020 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 158878004021 putative catalytic residues [active] 158878004022 putative nucleotide binding site [chemical binding]; other site 158878004023 putative aspartate binding site [chemical binding]; other site 158878004024 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 158878004025 allosteric regulatory residue; other site 158878004026 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 158878004027 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 158878004028 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 158878004029 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 158878004030 threonine synthase; Reviewed; Region: PRK06721 158878004031 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 158878004032 homodimer interface [polypeptide binding]; other site 158878004033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878004034 catalytic residue [active] 158878004035 homoserine kinase; Provisional; Region: PRK01212 158878004036 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 158878004037 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 158878004038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878004039 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 158878004040 active site 158878004041 motif I; other site 158878004042 motif II; other site 158878004043 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 158878004044 lysine transporter; Provisional; Region: PRK10836 158878004045 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 158878004046 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 158878004047 tetramer interface [polypeptide binding]; other site 158878004048 heme binding pocket [chemical binding]; other site 158878004049 NADPH binding site [chemical binding]; other site 158878004050 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 158878004051 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 158878004052 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 158878004053 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 158878004054 active site 158878004055 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 158878004056 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 158878004057 LexA repressor; Validated; Region: PRK00215 158878004058 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158878004059 putative DNA binding site [nucleotide binding]; other site 158878004060 putative Zn2+ binding site [ion binding]; other site 158878004061 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 158878004062 Catalytic site [active] 158878004063 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 158878004064 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 158878004065 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 158878004066 TPP-binding site [chemical binding]; other site 158878004067 dimer interface [polypeptide binding]; other site 158878004068 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 158878004069 PYR/PP interface [polypeptide binding]; other site 158878004070 dimer interface [polypeptide binding]; other site 158878004071 TPP binding site [chemical binding]; other site 158878004072 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158878004073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 158878004074 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 158878004075 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 158878004076 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 158878004077 active site 158878004078 metal binding site [ion binding]; metal-binding site 158878004079 DNA binding site [nucleotide binding] 158878004080 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 158878004081 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 158878004082 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 158878004083 Walker A/P-loop; other site 158878004084 ATP binding site [chemical binding]; other site 158878004085 Q-loop/lid; other site 158878004086 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 158878004087 ABC transporter signature motif; other site 158878004088 Walker B; other site 158878004089 D-loop; other site 158878004090 H-loop/switch region; other site 158878004091 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 158878004092 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 158878004093 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 158878004094 aconitate hydratase; Validated; Region: PRK09277 158878004095 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 158878004096 substrate binding site [chemical binding]; other site 158878004097 ligand binding site [chemical binding]; other site 158878004098 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 158878004099 substrate binding site [chemical binding]; other site 158878004100 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 158878004101 active site 158878004102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 158878004103 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 158878004104 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 158878004105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878004106 ATP binding site [chemical binding]; other site 158878004107 Mg2+ binding site [ion binding]; other site 158878004108 G-X-G motif; other site 158878004109 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 158878004110 anchoring element; other site 158878004111 dimer interface [polypeptide binding]; other site 158878004112 ATP binding site [chemical binding]; other site 158878004113 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 158878004114 active site 158878004115 putative metal-binding site [ion binding]; other site 158878004116 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 158878004117 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 158878004118 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 158878004119 CAP-like domain; other site 158878004120 active site 158878004121 primary dimer interface [polypeptide binding]; other site 158878004122 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158878004123 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 158878004124 amino acid carrier protein; Region: agcS; TIGR00835 158878004125 CAT RNA binding domain; Region: CAT_RBD; smart01061 158878004126 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 158878004127 PRD domain; Region: PRD; pfam00874 158878004128 PRD domain; Region: PRD; pfam00874 158878004129 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 158878004130 Domain of unknown function DUF20; Region: UPF0118; pfam01594 158878004131 Predicted integral membrane protein [Function unknown]; Region: COG0392 158878004132 Uncharacterized conserved protein [Function unknown]; Region: COG2898 158878004133 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 158878004134 methionine sulfoxide reductase A; Provisional; Region: PRK14054 158878004135 Transcriptional regulator [Transcription]; Region: LytR; COG1316 158878004136 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 158878004137 active site 1 [active] 158878004138 dimer interface [polypeptide binding]; other site 158878004139 hexamer interface [polypeptide binding]; other site 158878004140 active site 2 [active] 158878004141 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 158878004142 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 158878004143 active site 158878004144 DNA binding site [nucleotide binding] 158878004145 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 158878004146 prephenate dehydrogenase; Validated; Region: PRK06545 158878004147 prephenate dehydrogenase; Validated; Region: PRK08507 158878004148 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 158878004149 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 158878004150 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 158878004151 putative oligomer interface [polypeptide binding]; other site 158878004152 putative active site [active] 158878004153 metal binding site [ion binding]; metal-binding site 158878004154 anthranilate synthase component I; Provisional; Region: PRK13567 158878004155 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 158878004156 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 158878004157 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 158878004158 Glutamine amidotransferase class-I; Region: GATase; pfam00117 158878004159 glutamine binding [chemical binding]; other site 158878004160 catalytic triad [active] 158878004161 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 158878004162 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 158878004163 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 158878004164 active site 158878004165 ribulose/triose binding site [chemical binding]; other site 158878004166 phosphate binding site [ion binding]; other site 158878004167 substrate (anthranilate) binding pocket [chemical binding]; other site 158878004168 product (indole) binding pocket [chemical binding]; other site 158878004169 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 158878004170 active site 158878004171 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 158878004172 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 158878004173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878004174 catalytic residue [active] 158878004175 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 158878004176 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 158878004177 substrate binding site [chemical binding]; other site 158878004178 active site 158878004179 catalytic residues [active] 158878004180 heterodimer interface [polypeptide binding]; other site 158878004181 FemAB family; Region: FemAB; pfam02388 158878004182 FlxA-like protein; Region: FlxA; pfam14282 158878004183 FemAB family; Region: FemAB; pfam02388 158878004184 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 158878004185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878004186 active site 158878004187 motif I; other site 158878004188 motif II; other site 158878004189 SWIM zinc finger; Region: SWIM; pfam04434 158878004190 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 158878004191 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158878004192 Walker A/P-loop; other site 158878004193 ATP binding site [chemical binding]; other site 158878004194 Q-loop/lid; other site 158878004195 ABC transporter signature motif; other site 158878004196 Walker B; other site 158878004197 D-loop; other site 158878004198 H-loop/switch region; other site 158878004199 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158878004200 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 158878004201 Walker A/P-loop; other site 158878004202 ATP binding site [chemical binding]; other site 158878004203 Q-loop/lid; other site 158878004204 ABC transporter signature motif; other site 158878004205 Walker B; other site 158878004206 D-loop; other site 158878004207 H-loop/switch region; other site 158878004208 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 158878004209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878004210 dimer interface [polypeptide binding]; other site 158878004211 conserved gate region; other site 158878004212 putative PBP binding loops; other site 158878004213 ABC-ATPase subunit interface; other site 158878004214 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 158878004215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878004216 dimer interface [polypeptide binding]; other site 158878004217 conserved gate region; other site 158878004218 putative PBP binding loops; other site 158878004219 ABC-ATPase subunit interface; other site 158878004220 oligoendopeptidase F; Region: pepF; TIGR00181 158878004221 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 158878004222 active site 158878004223 Zn binding site [ion binding]; other site 158878004224 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 158878004225 PhoU domain; Region: PhoU; pfam01895 158878004226 PhoU domain; Region: PhoU; pfam01895 158878004227 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 158878004228 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 158878004229 Walker A/P-loop; other site 158878004230 ATP binding site [chemical binding]; other site 158878004231 Q-loop/lid; other site 158878004232 ABC transporter signature motif; other site 158878004233 Walker B; other site 158878004234 D-loop; other site 158878004235 H-loop/switch region; other site 158878004236 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 158878004237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878004238 dimer interface [polypeptide binding]; other site 158878004239 conserved gate region; other site 158878004240 putative PBP binding loops; other site 158878004241 ABC-ATPase subunit interface; other site 158878004242 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 158878004243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878004244 dimer interface [polypeptide binding]; other site 158878004245 conserved gate region; other site 158878004246 ABC-ATPase subunit interface; other site 158878004247 phosphate binding protein; Region: ptsS_2; TIGR02136 158878004248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 158878004249 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 158878004250 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 158878004251 S1 domain; Region: S1_2; pfam13509 158878004252 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 158878004253 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158878004254 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158878004255 ABC transporter; Region: ABC_tran_2; pfam12848 158878004256 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158878004257 aspartate kinase; Reviewed; Region: PRK06635 158878004258 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 158878004259 putative nucleotide binding site [chemical binding]; other site 158878004260 putative catalytic residues [active] 158878004261 putative Mg ion binding site [ion binding]; other site 158878004262 putative aspartate binding site [chemical binding]; other site 158878004263 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 158878004264 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 158878004265 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 158878004266 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 158878004267 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 158878004268 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 158878004269 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 158878004270 dimer interface [polypeptide binding]; other site 158878004271 active site 158878004272 catalytic residue [active] 158878004273 dihydrodipicolinate reductase; Provisional; Region: PRK00048 158878004274 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 158878004275 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 158878004276 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 158878004277 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 158878004278 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 158878004279 active site 158878004280 trimer interface [polypeptide binding]; other site 158878004281 substrate binding site [chemical binding]; other site 158878004282 CoA binding site [chemical binding]; other site 158878004283 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 158878004284 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 158878004285 metal binding site [ion binding]; metal-binding site 158878004286 dimer interface [polypeptide binding]; other site 158878004287 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 158878004288 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 158878004289 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158878004290 catalytic residue [active] 158878004291 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 158878004292 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 158878004293 active site 158878004294 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158878004295 substrate binding site [chemical binding]; other site 158878004296 catalytic residues [active] 158878004297 dimer interface [polypeptide binding]; other site 158878004298 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 158878004299 DNA-binding site [nucleotide binding]; DNA binding site 158878004300 RNA-binding motif; other site 158878004301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 158878004302 acylphosphatase; Provisional; Region: PRK14431 158878004303 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 158878004304 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 158878004305 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 158878004306 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 158878004307 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 158878004308 metal ion-dependent adhesion site (MIDAS); other site 158878004309 MoxR-like ATPases [General function prediction only]; Region: COG0714 158878004310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878004311 Walker A motif; other site 158878004312 ATP binding site [chemical binding]; other site 158878004313 Walker B motif; other site 158878004314 arginine finger; other site 158878004315 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 158878004316 active site 158878004317 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 158878004318 active site 158878004319 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 158878004320 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 158878004321 E3 interaction surface; other site 158878004322 lipoyl attachment site [posttranslational modification]; other site 158878004323 e3 binding domain; Region: E3_binding; pfam02817 158878004324 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 158878004325 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 158878004326 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 158878004327 TPP-binding site [chemical binding]; other site 158878004328 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 158878004329 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 158878004330 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158878004331 HAMP domain; Region: HAMP; pfam00672 158878004332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158878004333 dimer interface [polypeptide binding]; other site 158878004334 phosphorylation site [posttranslational modification] 158878004335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878004336 ATP binding site [chemical binding]; other site 158878004337 Mg2+ binding site [ion binding]; other site 158878004338 G-X-G motif; other site 158878004339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158878004340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878004341 active site 158878004342 phosphorylation site [posttranslational modification] 158878004343 intermolecular recognition site; other site 158878004344 dimerization interface [polypeptide binding]; other site 158878004345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158878004346 DNA binding site [nucleotide binding] 158878004347 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 158878004348 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 158878004349 active site 158878004350 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 158878004351 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 158878004352 active site 158878004353 homodimer interface [polypeptide binding]; other site 158878004354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878004355 Coenzyme A binding pocket [chemical binding]; other site 158878004356 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 158878004357 C-terminal peptidase (prc); Region: prc; TIGR00225 158878004358 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 158878004359 protein binding site [polypeptide binding]; other site 158878004360 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 158878004361 Catalytic dyad [active] 158878004362 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 158878004363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 158878004364 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 158878004365 HPr interaction site; other site 158878004366 glycerol kinase (GK) interaction site [polypeptide binding]; other site 158878004367 active site 158878004368 phosphorylation site [posttranslational modification] 158878004369 methionine sulfoxide reductase B; Provisional; Region: PRK00222 158878004370 SelR domain; Region: SelR; pfam01641 158878004371 methionine sulfoxide reductase A; Provisional; Region: PRK13014 158878004372 EDD domain protein, DegV family; Region: DegV; TIGR00762 158878004373 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 158878004374 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 158878004375 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 158878004376 folate binding site [chemical binding]; other site 158878004377 NADP+ binding site [chemical binding]; other site 158878004378 thymidylate synthase; Region: thym_sym; TIGR03284 158878004379 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 158878004380 dimerization interface [polypeptide binding]; other site 158878004381 active site 158878004382 Disulphide isomerase; Region: Disulph_isomer; pfam06491 158878004383 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 158878004384 Virulence factor; Region: Virulence_fact; pfam13769 158878004385 HEAT repeats; Region: HEAT_2; pfam13646 158878004386 HEAT repeat; Region: HEAT; pfam02985 158878004387 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 158878004388 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 158878004389 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 158878004390 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 158878004391 RNA/DNA hybrid binding site [nucleotide binding]; other site 158878004392 active site 158878004393 GA module; Region: GA; smart00844 158878004394 GA module; Region: GA; smart00844 158878004395 GA module; Region: GA; smart00844 158878004396 GA module; Region: GA; smart00844 158878004397 GA module; Region: GA; smart00844 158878004398 GA module; Region: GA; smart00844 158878004399 GA module; Region: GA; smart00844 158878004400 GA module; Region: GA; smart00844 158878004401 GA module; Region: GA; smart00844 158878004402 GA module; Region: GA; smart00844 158878004403 GA module; Region: GA; smart00844 158878004404 GA module; Region: GA; smart00844 158878004405 GA module; Region: GA; smart00844 158878004406 GA module; Region: GA; smart00844 158878004407 GA module; Region: GA; smart00844 158878004408 GA module; Region: GA; smart00844 158878004409 GA module; Region: GA; smart00844 158878004410 GA module; Region: GA; smart00844 158878004411 GA module; Region: GA; pfam01468 158878004412 GA module; Region: GA; smart00844 158878004413 GA module; Region: GA; smart00844 158878004414 GA module; Region: GA; smart00844 158878004415 GA module; Region: GA; smart00844 158878004416 GA module; Region: GA; pfam01468 158878004417 GA module; Region: GA; smart00844 158878004418 GA module; Region: GA; smart00844 158878004419 GA module; Region: GA; smart00844 158878004420 GA module; Region: GA; smart00844 158878004421 GA module; Region: GA; smart00844 158878004422 GA module; Region: GA; smart00844 158878004423 GA module; Region: GA; smart00844 158878004424 GA module; Region: GA; smart00844 158878004425 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 158878004426 GA module; Region: GA; pfam01468 158878004427 GA module; Region: GA; smart00844 158878004428 GA module; Region: GA; smart00844 158878004429 GA module; Region: GA; smart00844 158878004430 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 158878004431 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 158878004432 GA module; Region: GA; smart00844 158878004433 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 158878004434 GA module; Region: GA; smart00844 158878004435 GA module; Region: GA; smart00844 158878004436 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 158878004437 GA module; Region: GA; smart00844 158878004438 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 158878004439 GA module; Region: GA; smart00844 158878004440 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 158878004441 GA module; Region: GA; smart00844 158878004442 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 158878004443 GA module; Region: GA; smart00844 158878004444 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 158878004445 Amino acid permease; Region: AA_permease_2; pfam13520 158878004446 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 158878004447 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 158878004448 tetramer interface [polypeptide binding]; other site 158878004449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878004450 catalytic residue [active] 158878004451 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 158878004452 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 158878004453 hexamer interface [polypeptide binding]; other site 158878004454 ligand binding site [chemical binding]; other site 158878004455 putative active site [active] 158878004456 NAD(P) binding site [chemical binding]; other site 158878004457 5'-3' exonuclease; Region: 53EXOc; smart00475 158878004458 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 158878004459 active site 158878004460 metal binding site 1 [ion binding]; metal-binding site 158878004461 putative 5' ssDNA interaction site; other site 158878004462 metal binding site 3; metal-binding site 158878004463 metal binding site 2 [ion binding]; metal-binding site 158878004464 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 158878004465 putative DNA binding site [nucleotide binding]; other site 158878004466 putative metal binding site [ion binding]; other site 158878004467 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 158878004468 Dynamin family; Region: Dynamin_N; pfam00350 158878004469 G1 box; other site 158878004470 GTP/Mg2+ binding site [chemical binding]; other site 158878004471 G2 box; other site 158878004472 Switch I region; other site 158878004473 G3 box; other site 158878004474 Switch II region; other site 158878004475 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 158878004476 G4 box; other site 158878004477 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 158878004478 Dynamin family; Region: Dynamin_N; pfam00350 158878004479 G1 box; other site 158878004480 GTP/Mg2+ binding site [chemical binding]; other site 158878004481 G2 box; other site 158878004482 Switch I region; other site 158878004483 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 158878004484 G3 box; other site 158878004485 Switch II region; other site 158878004486 GTP/Mg2+ binding site [chemical binding]; other site 158878004487 G4 box; other site 158878004488 G5 box; other site 158878004489 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 158878004490 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 158878004491 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 158878004492 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 158878004493 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 158878004494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 158878004495 cell division protein GpsB; Provisional; Region: PRK14127 158878004496 DivIVA domain; Region: DivI1A_domain; TIGR03544 158878004497 hypothetical protein; Provisional; Region: PRK13660 158878004498 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 158878004499 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 158878004500 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 158878004501 Transglycosylase; Region: Transgly; pfam00912 158878004502 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 158878004503 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 158878004504 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 158878004505 minor groove reading motif; other site 158878004506 helix-hairpin-helix signature motif; other site 158878004507 substrate binding pocket [chemical binding]; other site 158878004508 active site 158878004509 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 158878004510 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 158878004511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 158878004512 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 158878004513 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 158878004514 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 158878004515 putative dimer interface [polypeptide binding]; other site 158878004516 putative anticodon binding site; other site 158878004517 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 158878004518 homodimer interface [polypeptide binding]; other site 158878004519 motif 1; other site 158878004520 motif 2; other site 158878004521 active site 158878004522 motif 3; other site 158878004523 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 158878004524 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 158878004525 active site 158878004526 catalytic site [active] 158878004527 substrate binding site [chemical binding]; other site 158878004528 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 158878004529 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 158878004530 Biotin operon repressor [Transcription]; Region: BirA; COG1654 158878004531 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 158878004532 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 158878004533 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 158878004534 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 158878004535 active site 158878004536 NTP binding site [chemical binding]; other site 158878004537 metal binding triad [ion binding]; metal-binding site 158878004538 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 158878004539 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 158878004540 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 158878004541 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 158878004542 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 158878004543 homodimer interface [polypeptide binding]; other site 158878004544 metal binding site [ion binding]; metal-binding site 158878004545 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 158878004546 Predicted membrane protein [Function unknown]; Region: COG4347 158878004547 Uncharacterized conserved protein [Function unknown]; Region: COG5582 158878004548 UPF0302 domain; Region: UPF0302; pfam08864 158878004549 A short protein domain of unknown function; Region: IDEAL; smart00914 158878004550 TPR repeat; Region: TPR_11; pfam13414 158878004551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158878004552 binding surface 158878004553 TPR motif; other site 158878004554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158878004555 TPR motif; other site 158878004556 binding surface 158878004557 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 158878004558 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 158878004559 hinge; other site 158878004560 active site 158878004561 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 158878004562 active site 158878004563 NAD binding site [chemical binding]; other site 158878004564 metal binding site [ion binding]; metal-binding site 158878004565 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 158878004566 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 158878004567 Tetramer interface [polypeptide binding]; other site 158878004568 active site 158878004569 FMN-binding site [chemical binding]; other site 158878004570 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 158878004571 active site 158878004572 multimer interface [polypeptide binding]; other site 158878004573 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 158878004574 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 158878004575 substrate binding pocket [chemical binding]; other site 158878004576 chain length determination region; other site 158878004577 substrate-Mg2+ binding site; other site 158878004578 catalytic residues [active] 158878004579 aspartate-rich region 1; other site 158878004580 active site lid residues [active] 158878004581 aspartate-rich region 2; other site 158878004582 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 158878004583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878004584 S-adenosylmethionine binding site [chemical binding]; other site 158878004585 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 158878004586 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 158878004587 IHF dimer interface [polypeptide binding]; other site 158878004588 IHF - DNA interface [nucleotide binding]; other site 158878004589 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 158878004590 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 158878004591 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 158878004592 GTP-binding protein Der; Reviewed; Region: PRK00093 158878004593 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 158878004594 G1 box; other site 158878004595 GTP/Mg2+ binding site [chemical binding]; other site 158878004596 Switch I region; other site 158878004597 G2 box; other site 158878004598 Switch II region; other site 158878004599 G3 box; other site 158878004600 G4 box; other site 158878004601 G5 box; other site 158878004602 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 158878004603 G1 box; other site 158878004604 GTP/Mg2+ binding site [chemical binding]; other site 158878004605 Switch I region; other site 158878004606 G2 box; other site 158878004607 G3 box; other site 158878004608 Switch II region; other site 158878004609 G4 box; other site 158878004610 G5 box; other site 158878004611 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 158878004612 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 158878004613 RNA binding site [nucleotide binding]; other site 158878004614 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 158878004615 RNA binding site [nucleotide binding]; other site 158878004616 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 158878004617 RNA binding site [nucleotide binding]; other site 158878004618 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 158878004619 RNA binding site [nucleotide binding]; other site 158878004620 cytidylate kinase; Provisional; Region: cmk; PRK00023 158878004621 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 158878004622 CMP-binding site; other site 158878004623 The sites determining sugar specificity; other site 158878004624 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 158878004625 active site 158878004626 homotetramer interface [polypeptide binding]; other site 158878004627 homodimer interface [polypeptide binding]; other site 158878004628 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 158878004629 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 158878004630 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158878004631 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 158878004632 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 158878004633 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158878004634 ATP binding site [chemical binding]; other site 158878004635 putative Mg++ binding site [ion binding]; other site 158878004636 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158878004637 nucleotide binding region [chemical binding]; other site 158878004638 ATP-binding site [chemical binding]; other site 158878004639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 158878004640 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 158878004641 Predicted membrane protein [Function unknown]; Region: COG3601 158878004642 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 158878004643 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 158878004644 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 158878004645 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 158878004646 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 158878004647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158878004648 dimerization interface [polypeptide binding]; other site 158878004649 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 158878004650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158878004651 dimer interface [polypeptide binding]; other site 158878004652 phosphorylation site [posttranslational modification] 158878004653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878004654 ATP binding site [chemical binding]; other site 158878004655 Mg2+ binding site [ion binding]; other site 158878004656 G-X-G motif; other site 158878004657 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158878004658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878004659 active site 158878004660 phosphorylation site [posttranslational modification] 158878004661 intermolecular recognition site; other site 158878004662 dimerization interface [polypeptide binding]; other site 158878004663 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158878004664 DNA binding site [nucleotide binding] 158878004665 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 158878004666 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 158878004667 RNA binding surface [nucleotide binding]; other site 158878004668 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 158878004669 active site 158878004670 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 158878004671 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 158878004672 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 158878004673 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 158878004674 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 158878004675 active site 158878004676 Int/Topo IB signature motif; other site 158878004677 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 158878004678 metal binding site 2 [ion binding]; metal-binding site 158878004679 putative DNA binding helix; other site 158878004680 metal binding site 1 [ion binding]; metal-binding site 158878004681 dimer interface [polypeptide binding]; other site 158878004682 structural Zn2+ binding site [ion binding]; other site 158878004683 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 158878004684 dimer interface [polypeptide binding]; other site 158878004685 ADP-ribose binding site [chemical binding]; other site 158878004686 active site 158878004687 nudix motif; other site 158878004688 metal binding site [ion binding]; metal-binding site 158878004689 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158878004690 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158878004691 active site 158878004692 catalytic tetrad [active] 158878004693 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 158878004694 classical (c) SDRs; Region: SDR_c; cd05233 158878004695 NAD(P) binding site [chemical binding]; other site 158878004696 active site 158878004697 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 158878004698 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 158878004699 ribonuclease Z; Region: RNase_Z; TIGR02651 158878004700 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 158878004701 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 158878004702 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 158878004703 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158878004704 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 158878004705 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 158878004706 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 158878004707 Ca binding site [ion binding]; other site 158878004708 active site 158878004709 catalytic site [active] 158878004710 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158878004711 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158878004712 DNA binding site [nucleotide binding] 158878004713 domain linker motif; other site 158878004714 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 158878004715 putative ligand binding site [chemical binding]; other site 158878004716 putative dimerization interface [polypeptide binding]; other site 158878004717 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158878004718 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 158878004719 H+ Antiporter protein; Region: 2A0121; TIGR00900 158878004720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878004721 putative substrate translocation pore; other site 158878004722 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 158878004723 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 158878004724 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 158878004725 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 158878004726 peptidase T-like protein; Region: PepT-like; TIGR01883 158878004727 metal binding site [ion binding]; metal-binding site 158878004728 putative dimer interface [polypeptide binding]; other site 158878004729 Predicted membrane protein [Function unknown]; Region: COG4129 158878004730 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 158878004731 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 158878004732 Disulphide isomerase; Region: Disulph_isomer; pfam06491 158878004733 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 158878004734 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 158878004735 E3 interaction surface; other site 158878004736 lipoyl attachment site [posttranslational modification]; other site 158878004737 e3 binding domain; Region: E3_binding; pfam02817 158878004738 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 158878004739 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 158878004740 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 158878004741 alpha subunit interface [polypeptide binding]; other site 158878004742 TPP binding site [chemical binding]; other site 158878004743 heterodimer interface [polypeptide binding]; other site 158878004744 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158878004745 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 158878004746 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 158878004747 tetramer interface [polypeptide binding]; other site 158878004748 TPP-binding site [chemical binding]; other site 158878004749 heterodimer interface [polypeptide binding]; other site 158878004750 phosphorylation loop region [posttranslational modification] 158878004751 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 158878004752 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 158878004753 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158878004754 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 158878004755 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 158878004756 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 158878004757 Walker A/P-loop; other site 158878004758 ATP binding site [chemical binding]; other site 158878004759 Q-loop/lid; other site 158878004760 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 158878004761 ABC transporter signature motif; other site 158878004762 Walker B; other site 158878004763 D-loop; other site 158878004764 H-loop/switch region; other site 158878004765 arginine repressor; Provisional; Region: PRK04280 158878004766 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 158878004767 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 158878004768 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 158878004769 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 158878004770 substrate binding pocket [chemical binding]; other site 158878004771 chain length determination region; other site 158878004772 substrate-Mg2+ binding site; other site 158878004773 catalytic residues [active] 158878004774 aspartate-rich region 1; other site 158878004775 active site lid residues [active] 158878004776 aspartate-rich region 2; other site 158878004777 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 158878004778 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 158878004779 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 158878004780 generic binding surface II; other site 158878004781 generic binding surface I; other site 158878004782 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 158878004783 putative RNA binding site [nucleotide binding]; other site 158878004784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 158878004785 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 158878004786 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 158878004787 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 158878004788 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 158878004789 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 158878004790 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 158878004791 carboxyltransferase (CT) interaction site; other site 158878004792 biotinylation site [posttranslational modification]; other site 158878004793 elongation factor P; Validated; Region: PRK00529 158878004794 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 158878004795 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 158878004796 RNA binding site [nucleotide binding]; other site 158878004797 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 158878004798 RNA binding site [nucleotide binding]; other site 158878004799 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 158878004800 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 158878004801 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 158878004802 active site 158878004803 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 158878004804 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 158878004805 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 158878004806 active site residue [active] 158878004807 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 158878004808 tetramer interface [polypeptide binding]; other site 158878004809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878004810 catalytic residue [active] 158878004811 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 158878004812 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 158878004813 tetramer interface [polypeptide binding]; other site 158878004814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878004815 catalytic residue [active] 158878004816 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 158878004817 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 158878004818 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 158878004819 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 158878004820 ADP binding site [chemical binding]; other site 158878004821 magnesium binding site [ion binding]; other site 158878004822 putative shikimate binding site; other site 158878004823 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 158878004824 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 158878004825 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 158878004826 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 158878004827 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 158878004828 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 158878004829 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 158878004830 Type II/IV secretion system protein; Region: T2SE; pfam00437 158878004831 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 158878004832 Walker A motif; other site 158878004833 ATP binding site [chemical binding]; other site 158878004834 Walker B motif; other site 158878004835 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158878004836 Uncharacterized conserved protein [Function unknown]; Region: COG0011 158878004837 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 158878004838 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 158878004839 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 158878004840 Rhomboid family; Region: Rhomboid; pfam01694 158878004841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158878004842 binding surface 158878004843 TPR motif; other site 158878004844 Tetratricopeptide repeat; Region: TPR_16; pfam13432 158878004845 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 158878004846 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 158878004847 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 158878004848 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 158878004849 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 158878004850 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 158878004851 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 158878004852 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 158878004853 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 158878004854 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 158878004855 metal binding site 2 [ion binding]; metal-binding site 158878004856 putative DNA binding helix; other site 158878004857 metal binding site 1 [ion binding]; metal-binding site 158878004858 dimer interface [polypeptide binding]; other site 158878004859 structural Zn2+ binding site [ion binding]; other site 158878004860 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 158878004861 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158878004862 ABC-ATPase subunit interface; other site 158878004863 dimer interface [polypeptide binding]; other site 158878004864 putative PBP binding regions; other site 158878004865 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 158878004866 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 158878004867 endonuclease IV; Provisional; Region: PRK01060 158878004868 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 158878004869 AP (apurinic/apyrimidinic) site pocket; other site 158878004870 DNA interaction; other site 158878004871 Metal-binding active site; metal-binding site 158878004872 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 158878004873 DEAD-like helicases superfamily; Region: DEXDc; smart00487 158878004874 ATP binding site [chemical binding]; other site 158878004875 putative Mg++ binding site [ion binding]; other site 158878004876 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158878004877 nucleotide binding region [chemical binding]; other site 158878004878 ATP-binding site [chemical binding]; other site 158878004879 Uncharacterized conserved protein [Function unknown]; Region: COG0327 158878004880 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 158878004881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 158878004882 Uncharacterized conserved protein [Function unknown]; Region: COG0327 158878004883 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 158878004884 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 158878004885 Family of unknown function (DUF633); Region: DUF633; pfam04816 158878004886 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 158878004887 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 158878004888 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 158878004889 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 158878004890 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 158878004891 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 158878004892 DNA binding residues [nucleotide binding] 158878004893 DNA primase, catalytic core; Region: dnaG; TIGR01391 158878004894 CHC2 zinc finger; Region: zf-CHC2; pfam01807 158878004895 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 158878004896 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 158878004897 active site 158878004898 metal binding site [ion binding]; metal-binding site 158878004899 interdomain interaction site; other site 158878004900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 158878004901 HTH domain; Region: HTH_11; pfam08279 158878004902 FOG: CBS domain [General function prediction only]; Region: COG0517 158878004903 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 158878004904 glycyl-tRNA synthetase; Provisional; Region: PRK04173 158878004905 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 158878004906 motif 1; other site 158878004907 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 158878004908 active site 158878004909 motif 2; other site 158878004910 motif 3; other site 158878004911 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 158878004912 anticodon binding site; other site 158878004913 DNA repair protein RecO; Region: reco; TIGR00613 158878004914 Recombination protein O N terminal; Region: RecO_N; pfam11967 158878004915 Recombination protein O C terminal; Region: RecO_C; pfam02565 158878004916 GTPase Era; Reviewed; Region: era; PRK00089 158878004917 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 158878004918 G1 box; other site 158878004919 GTP/Mg2+ binding site [chemical binding]; other site 158878004920 Switch I region; other site 158878004921 G2 box; other site 158878004922 Switch II region; other site 158878004923 G3 box; other site 158878004924 G4 box; other site 158878004925 G5 box; other site 158878004926 KH domain; Region: KH_2; pfam07650 158878004927 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 158878004928 active site 158878004929 catalytic motif [active] 158878004930 Zn binding site [ion binding]; other site 158878004931 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 158878004932 metal-binding heat shock protein; Provisional; Region: PRK00016 158878004933 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 158878004934 PhoH-like protein; Region: PhoH; pfam02562 158878004935 hypothetical protein; Provisional; Region: PRK13665 158878004936 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 158878004937 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 158878004938 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 158878004939 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 158878004940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158878004941 FeS/SAM binding site; other site 158878004942 TRAM domain; Region: TRAM; cl01282 158878004943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 158878004944 RNA methyltransferase, RsmE family; Region: TIGR00046 158878004945 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 158878004946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878004947 S-adenosylmethionine binding site [chemical binding]; other site 158878004948 chaperone protein DnaJ; Provisional; Region: PRK14280 158878004949 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 158878004950 HSP70 interaction site [polypeptide binding]; other site 158878004951 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 158878004952 substrate binding site [polypeptide binding]; other site 158878004953 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 158878004954 Zn binding sites [ion binding]; other site 158878004955 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 158878004956 dimer interface [polypeptide binding]; other site 158878004957 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 158878004958 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 158878004959 nucleotide binding site [chemical binding]; other site 158878004960 NEF interaction site [polypeptide binding]; other site 158878004961 SBD interface [polypeptide binding]; other site 158878004962 heat shock protein GrpE; Provisional; Region: PRK14140 158878004963 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 158878004964 dimer interface [polypeptide binding]; other site 158878004965 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 158878004966 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 158878004967 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 158878004968 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 158878004969 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 158878004970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158878004971 FeS/SAM binding site; other site 158878004972 HemN C-terminal domain; Region: HemN_C; pfam06969 158878004973 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 158878004974 GTP-binding protein LepA; Provisional; Region: PRK05433 158878004975 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 158878004976 G1 box; other site 158878004977 putative GEF interaction site [polypeptide binding]; other site 158878004978 GTP/Mg2+ binding site [chemical binding]; other site 158878004979 Switch I region; other site 158878004980 G2 box; other site 158878004981 G3 box; other site 158878004982 Switch II region; other site 158878004983 G4 box; other site 158878004984 G5 box; other site 158878004985 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 158878004986 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 158878004987 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 158878004988 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 158878004989 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 158878004990 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 158878004991 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 158878004992 Competence protein; Region: Competence; pfam03772 158878004993 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 158878004994 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158878004995 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 158878004996 catalytic motif [active] 158878004997 Zn binding site [ion binding]; other site 158878004998 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 158878004999 Helix-hairpin-helix motif; Region: HHH; pfam00633 158878005000 Methyltransferase domain; Region: Methyltransf_31; pfam13847 158878005001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878005002 S-adenosylmethionine binding site [chemical binding]; other site 158878005003 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 158878005004 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158878005005 Zn2+ binding site [ion binding]; other site 158878005006 Mg2+ binding site [ion binding]; other site 158878005007 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 158878005008 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 158878005009 active site 158878005010 (T/H)XGH motif; other site 158878005011 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 158878005012 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 158878005013 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 158878005014 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 158878005015 shikimate binding site; other site 158878005016 NAD(P) binding site [chemical binding]; other site 158878005017 GTPase YqeH; Provisional; Region: PRK13796 158878005018 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 158878005019 GTP/Mg2+ binding site [chemical binding]; other site 158878005020 G4 box; other site 158878005021 G5 box; other site 158878005022 G1 box; other site 158878005023 Switch I region; other site 158878005024 G2 box; other site 158878005025 G3 box; other site 158878005026 Switch II region; other site 158878005027 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 158878005028 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878005029 active site 158878005030 motif I; other site 158878005031 motif II; other site 158878005032 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 158878005033 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 158878005034 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878005035 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 158878005036 Fic family protein [Function unknown]; Region: COG3177 158878005037 Fic/DOC family; Region: Fic; pfam02661 158878005038 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 158878005039 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 158878005040 putative active site [active] 158878005041 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 158878005042 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 158878005043 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158878005044 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 158878005045 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 158878005046 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 158878005047 carboxyltransferase (CT) interaction site; other site 158878005048 biotinylation site [posttranslational modification]; other site 158878005049 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 158878005050 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 158878005051 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 158878005052 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 158878005053 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 158878005054 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 158878005055 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 158878005056 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 158878005057 Sugar specificity; other site 158878005058 Pyrimidine base specificity; other site 158878005059 ATP-binding site [chemical binding]; other site 158878005060 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 158878005061 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 158878005062 Peptidase family U32; Region: Peptidase_U32; pfam01136 158878005063 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 158878005064 Peptidase family U32; Region: Peptidase_U32; pfam01136 158878005065 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 158878005066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878005067 S-adenosylmethionine binding site [chemical binding]; other site 158878005068 hypothetical protein; Provisional; Region: PRK13678 158878005069 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 158878005070 hypothetical protein; Provisional; Region: PRK05473 158878005071 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 158878005072 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 158878005073 motif 1; other site 158878005074 active site 158878005075 motif 2; other site 158878005076 motif 3; other site 158878005077 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 158878005078 DHHA1 domain; Region: DHHA1; pfam02272 158878005079 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 158878005080 AAA domain; Region: AAA_30; pfam13604 158878005081 Family description; Region: UvrD_C_2; pfam13538 158878005082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158878005083 binding surface 158878005084 TPR motif; other site 158878005085 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 158878005086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158878005087 binding surface 158878005088 TPR motif; other site 158878005089 TPR repeat; Region: TPR_11; pfam13414 158878005090 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 158878005091 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 158878005092 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 158878005093 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 158878005094 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158878005095 catalytic residue [active] 158878005096 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 158878005097 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 158878005098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 158878005099 Predicted transcriptional regulator [Transcription]; Region: COG1959 158878005100 Transcriptional regulator; Region: Rrf2; pfam02082 158878005101 recombination factor protein RarA; Reviewed; Region: PRK13342 158878005102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878005103 Walker A motif; other site 158878005104 ATP binding site [chemical binding]; other site 158878005105 Walker B motif; other site 158878005106 arginine finger; other site 158878005107 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 158878005108 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 158878005109 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 158878005110 putative ATP binding site [chemical binding]; other site 158878005111 putative substrate interface [chemical binding]; other site 158878005112 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 158878005113 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 158878005114 dimer interface [polypeptide binding]; other site 158878005115 anticodon binding site; other site 158878005116 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 158878005117 homodimer interface [polypeptide binding]; other site 158878005118 motif 1; other site 158878005119 active site 158878005120 motif 2; other site 158878005121 GAD domain; Region: GAD; pfam02938 158878005122 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 158878005123 motif 3; other site 158878005124 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 158878005125 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 158878005126 dimer interface [polypeptide binding]; other site 158878005127 motif 1; other site 158878005128 active site 158878005129 motif 2; other site 158878005130 motif 3; other site 158878005131 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 158878005132 anticodon binding site; other site 158878005133 Bacterial SH3 domain homologues; Region: SH3b; smart00287 158878005134 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 158878005135 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 158878005136 active site 158878005137 metal binding site [ion binding]; metal-binding site 158878005138 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 158878005139 putative active site [active] 158878005140 dimerization interface [polypeptide binding]; other site 158878005141 putative tRNAtyr binding site [nucleotide binding]; other site 158878005142 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 158878005143 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158878005144 Zn2+ binding site [ion binding]; other site 158878005145 Mg2+ binding site [ion binding]; other site 158878005146 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 158878005147 synthetase active site [active] 158878005148 NTP binding site [chemical binding]; other site 158878005149 metal binding site [ion binding]; metal-binding site 158878005150 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 158878005151 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 158878005152 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158878005153 active site 158878005154 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 158878005155 DHH family; Region: DHH; pfam01368 158878005156 DHHA1 domain; Region: DHHA1; pfam02272 158878005157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 158878005158 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 158878005159 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 158878005160 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 158878005161 Protein export membrane protein; Region: SecD_SecF; pfam02355 158878005162 Preprotein translocase subunit; Region: YajC; pfam02699 158878005163 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 158878005164 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 158878005165 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 158878005166 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 158878005167 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 158878005168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878005169 Walker A motif; other site 158878005170 ATP binding site [chemical binding]; other site 158878005171 Walker B motif; other site 158878005172 arginine finger; other site 158878005173 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 158878005174 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 158878005175 RuvA N terminal domain; Region: RuvA_N; pfam01330 158878005176 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 158878005177 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 158878005178 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 158878005179 GTPase CgtA; Reviewed; Region: obgE; PRK12297 158878005180 GTP1/OBG; Region: GTP1_OBG; pfam01018 158878005181 Obg GTPase; Region: Obg; cd01898 158878005182 G1 box; other site 158878005183 GTP/Mg2+ binding site [chemical binding]; other site 158878005184 Switch I region; other site 158878005185 G2 box; other site 158878005186 G3 box; other site 158878005187 Switch II region; other site 158878005188 G4 box; other site 158878005189 G5 box; other site 158878005190 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 158878005191 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 158878005192 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 158878005193 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 158878005194 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 158878005195 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 158878005196 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 158878005197 rod shape-determining protein MreC; Region: MreC; pfam04085 158878005198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878005199 S-adenosylmethionine binding site [chemical binding]; other site 158878005200 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 158878005201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878005202 S-adenosylmethionine binding site [chemical binding]; other site 158878005203 aminoglycoside resistance protein; Provisional; Region: PRK13746 158878005204 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 158878005205 active site 158878005206 NTP binding site [chemical binding]; other site 158878005207 metal binding triad [ion binding]; metal-binding site 158878005208 antibiotic binding site [chemical binding]; other site 158878005209 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 158878005210 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 158878005211 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 158878005212 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 158878005213 Int/Topo IB signature motif; other site 158878005214 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 158878005215 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 158878005216 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 158878005217 Int/Topo IB signature motif; other site 158878005218 hypothetical protein; Reviewed; Region: PRK00024 158878005219 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 158878005220 MPN+ (JAMM) motif; other site 158878005221 Zinc-binding site [ion binding]; other site 158878005222 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 158878005223 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 158878005224 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 158878005225 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 158878005226 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 158878005227 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 158878005228 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 158878005229 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158878005230 active site 158878005231 HIGH motif; other site 158878005232 nucleotide binding site [chemical binding]; other site 158878005233 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 158878005234 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 158878005235 active site 158878005236 KMSKS motif; other site 158878005237 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 158878005238 tRNA binding surface [nucleotide binding]; other site 158878005239 anticodon binding site; other site 158878005240 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 158878005241 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 158878005242 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 158878005243 Putative ammonia monooxygenase; Region: AmoA; pfam05145 158878005244 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 158878005245 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 158878005246 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 158878005247 inhibitor-cofactor binding pocket; inhibition site 158878005248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878005249 catalytic residue [active] 158878005250 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 158878005251 dimer interface [polypeptide binding]; other site 158878005252 active site 158878005253 Schiff base residues; other site 158878005254 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 158878005255 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 158878005256 active site 158878005257 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 158878005258 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 158878005259 domain interfaces; other site 158878005260 active site 158878005261 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 158878005262 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 158878005263 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 158878005264 tRNA; other site 158878005265 putative tRNA binding site [nucleotide binding]; other site 158878005266 putative NADP binding site [chemical binding]; other site 158878005267 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 158878005268 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 158878005269 G1 box; other site 158878005270 GTP/Mg2+ binding site [chemical binding]; other site 158878005271 Switch I region; other site 158878005272 G2 box; other site 158878005273 G3 box; other site 158878005274 Switch II region; other site 158878005275 G4 box; other site 158878005276 G5 box; other site 158878005277 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 158878005278 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 158878005279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878005280 Walker A motif; other site 158878005281 ATP binding site [chemical binding]; other site 158878005282 Walker B motif; other site 158878005283 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 158878005284 trigger factor; Provisional; Region: tig; PRK01490 158878005285 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 158878005286 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 158878005287 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 158878005288 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 158878005289 23S rRNA binding site [nucleotide binding]; other site 158878005290 L21 binding site [polypeptide binding]; other site 158878005291 L13 binding site [polypeptide binding]; other site 158878005292 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 158878005293 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 158878005294 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 158878005295 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 158878005296 lysine transporter; Provisional; Region: PRK10836 158878005297 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 158878005298 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 158878005299 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 158878005300 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 158878005301 active site 158878005302 dimer interface [polypeptide binding]; other site 158878005303 motif 1; other site 158878005304 motif 2; other site 158878005305 motif 3; other site 158878005306 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 158878005307 anticodon binding site; other site 158878005308 primosomal protein DnaI; Reviewed; Region: PRK08939 158878005309 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 158878005310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878005311 Walker A motif; other site 158878005312 ATP binding site [chemical binding]; other site 158878005313 Walker B motif; other site 158878005314 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 158878005315 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 158878005316 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 158878005317 ATP cone domain; Region: ATP-cone; pfam03477 158878005318 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 158878005319 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 158878005320 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 158878005321 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 158878005322 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 158878005323 CoA-binding site [chemical binding]; other site 158878005324 ATP-binding [chemical binding]; other site 158878005325 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 158878005326 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 158878005327 DNA binding site [nucleotide binding] 158878005328 catalytic residue [active] 158878005329 H2TH interface [polypeptide binding]; other site 158878005330 putative catalytic residues [active] 158878005331 turnover-facilitating residue; other site 158878005332 intercalation triad [nucleotide binding]; other site 158878005333 8OG recognition residue [nucleotide binding]; other site 158878005334 putative reading head residues; other site 158878005335 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 158878005336 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 158878005337 DNA polymerase I; Provisional; Region: PRK05755 158878005338 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 158878005339 active site 158878005340 metal binding site 1 [ion binding]; metal-binding site 158878005341 putative 5' ssDNA interaction site; other site 158878005342 metal binding site 3; metal-binding site 158878005343 metal binding site 2 [ion binding]; metal-binding site 158878005344 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 158878005345 putative DNA binding site [nucleotide binding]; other site 158878005346 putative metal binding site [ion binding]; other site 158878005347 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 158878005348 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 158878005349 active site 158878005350 DNA binding site [nucleotide binding] 158878005351 catalytic site [active] 158878005352 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 158878005353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158878005354 dimer interface [polypeptide binding]; other site 158878005355 phosphorylation site [posttranslational modification] 158878005356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878005357 ATP binding site [chemical binding]; other site 158878005358 Mg2+ binding site [ion binding]; other site 158878005359 G-X-G motif; other site 158878005360 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158878005361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878005362 active site 158878005363 phosphorylation site [posttranslational modification] 158878005364 intermolecular recognition site; other site 158878005365 dimerization interface [polypeptide binding]; other site 158878005366 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158878005367 DNA binding site [nucleotide binding] 158878005368 isocitrate dehydrogenase; Reviewed; Region: PRK07006 158878005369 isocitrate dehydrogenase; Validated; Region: PRK07362 158878005370 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 158878005371 dimer interface [polypeptide binding]; other site 158878005372 Citrate synthase; Region: Citrate_synt; pfam00285 158878005373 active site 158878005374 citrylCoA binding site [chemical binding]; other site 158878005375 oxalacetate/citrate binding site [chemical binding]; other site 158878005376 coenzyme A binding site [chemical binding]; other site 158878005377 catalytic triad [active] 158878005378 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 158878005379 pyruvate kinase; Provisional; Region: PRK06354 158878005380 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 158878005381 domain interfaces; other site 158878005382 active site 158878005383 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 158878005384 6-phosphofructokinase; Provisional; Region: PRK03202 158878005385 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 158878005386 dimerization interface [polypeptide binding]; other site 158878005387 allosteric effector site; other site 158878005388 active site 158878005389 ADP/pyrophosphate binding site [chemical binding]; other site 158878005390 fructose-1,6-bisphosphate binding site; other site 158878005391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 158878005392 Transposase; Region: DDE_Tnp_ISL3; pfam01610 158878005393 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 158878005394 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 158878005395 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 158878005396 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 158878005397 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 158878005398 Malic enzyme, N-terminal domain; Region: malic; pfam00390 158878005399 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 158878005400 putative NAD(P) binding site [chemical binding]; other site 158878005401 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 158878005402 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 158878005403 active site 158878005404 PHP Thumb interface [polypeptide binding]; other site 158878005405 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 158878005406 generic binding surface I; other site 158878005407 generic binding surface II; other site 158878005408 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 158878005409 DHH family; Region: DHH; pfam01368 158878005410 DHHA1 domain; Region: DHHA1; pfam02272 158878005411 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 158878005412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 158878005413 DNA-binding site [nucleotide binding]; DNA binding site 158878005414 DRTGG domain; Region: DRTGG; pfam07085 158878005415 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 158878005416 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 158878005417 active site 2 [active] 158878005418 active site 1 [active] 158878005419 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 158878005420 Ligand Binding Site [chemical binding]; other site 158878005421 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 158878005422 metal-dependent hydrolase; Provisional; Region: PRK00685 158878005423 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 158878005424 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 158878005425 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 158878005426 active site 158878005427 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 158878005428 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 158878005429 hexamer interface [polypeptide binding]; other site 158878005430 ligand binding site [chemical binding]; other site 158878005431 putative active site [active] 158878005432 NAD(P) binding site [chemical binding]; other site 158878005433 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 158878005434 Ligand Binding Site [chemical binding]; other site 158878005435 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 158878005436 propionate/acetate kinase; Provisional; Region: PRK12379 158878005437 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 158878005438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878005439 S-adenosylmethionine binding site [chemical binding]; other site 158878005440 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 158878005441 dimer interface [polypeptide binding]; other site 158878005442 catalytic triad [active] 158878005443 peroxidatic and resolving cysteines [active] 158878005444 hypothetical protein; Provisional; Region: PRK10621 158878005445 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 158878005446 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 158878005447 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 158878005448 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 158878005449 Ligand Binding Site [chemical binding]; other site 158878005450 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 158878005451 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 158878005452 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158878005453 catalytic residue [active] 158878005454 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 158878005455 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 158878005456 GAF domain; Region: GAF_2; pfam13185 158878005457 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 158878005458 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 158878005459 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 158878005460 RNA binding surface [nucleotide binding]; other site 158878005461 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 158878005462 Transposase; Region: DDE_Tnp_ISL3; pfam01610 158878005463 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 158878005464 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 158878005465 active site 158878005466 catalytic site [active] 158878005467 OsmC-like protein; Region: OsmC; cl00767 158878005468 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 158878005469 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158878005470 catalytic residue [active] 158878005471 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 158878005472 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 158878005473 ligand binding site [chemical binding]; other site 158878005474 NAD binding site [chemical binding]; other site 158878005475 dimerization interface [polypeptide binding]; other site 158878005476 catalytic site [active] 158878005477 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 158878005478 putative L-serine binding site [chemical binding]; other site 158878005479 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 158878005480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878005481 motif II; other site 158878005482 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 158878005483 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 158878005484 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 158878005485 active site turn [active] 158878005486 phosphorylation site [posttranslational modification] 158878005487 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 158878005488 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 158878005489 putative acyl-acceptor binding pocket; other site 158878005490 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 158878005491 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 158878005492 protein binding site [polypeptide binding]; other site 158878005493 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 158878005494 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 158878005495 active site 158878005496 HIGH motif; other site 158878005497 dimer interface [polypeptide binding]; other site 158878005498 KMSKS motif; other site 158878005499 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 158878005500 RNA binding surface [nucleotide binding]; other site 158878005501 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 158878005502 Transglycosylase; Region: Transgly; pfam00912 158878005503 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 158878005504 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 158878005505 NEAr Transporter domain; Region: NEAT; smart00725 158878005506 NEAr Transporter domain; Region: NEAT; smart00725 158878005507 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 158878005508 heme-binding site [chemical binding]; other site 158878005509 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 158878005510 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 158878005511 Potassium binding sites [ion binding]; other site 158878005512 Cesium cation binding sites [ion binding]; other site 158878005513 acetyl-CoA synthetase; Provisional; Region: PRK04319 158878005514 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 158878005515 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 158878005516 active site 158878005517 acyl-activating enzyme (AAE) consensus motif; other site 158878005518 putative CoA binding site [chemical binding]; other site 158878005519 AMP binding site [chemical binding]; other site 158878005520 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 158878005521 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 158878005522 active site 158878005523 Zn binding site [ion binding]; other site 158878005524 catabolite control protein A; Region: ccpA; TIGR01481 158878005525 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158878005526 DNA binding site [nucleotide binding] 158878005527 domain linker motif; other site 158878005528 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 158878005529 dimerization interface [polypeptide binding]; other site 158878005530 effector binding site; other site 158878005531 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 158878005532 Chorismate mutase type II; Region: CM_2; cl00693 158878005533 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 158878005534 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 158878005535 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 158878005536 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 158878005537 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 158878005538 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 158878005539 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 158878005540 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 158878005541 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 158878005542 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 158878005543 putative tRNA-binding site [nucleotide binding]; other site 158878005544 hypothetical protein; Provisional; Region: PRK13668 158878005545 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 158878005546 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 158878005547 catalytic residues [active] 158878005548 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 158878005549 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 158878005550 oligomer interface [polypeptide binding]; other site 158878005551 active site 158878005552 metal binding site [ion binding]; metal-binding site 158878005553 Predicted small secreted protein [Function unknown]; Region: COG5584 158878005554 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 158878005555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878005556 S-adenosylmethionine binding site [chemical binding]; other site 158878005557 Phosphotransferase enzyme family; Region: APH; pfam01636 158878005558 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 158878005559 active site 158878005560 substrate binding site [chemical binding]; other site 158878005561 ATP binding site [chemical binding]; other site 158878005562 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 158878005563 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 158878005564 homodimer interface [polypeptide binding]; other site 158878005565 substrate-cofactor binding pocket; other site 158878005566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878005567 catalytic residue [active] 158878005568 dipeptidase PepV; Reviewed; Region: PRK07318 158878005569 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 158878005570 active site 158878005571 metal binding site [ion binding]; metal-binding site 158878005572 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 158878005573 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 158878005574 RNA binding surface [nucleotide binding]; other site 158878005575 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 158878005576 active site 158878005577 uracil binding [chemical binding]; other site 158878005578 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 158878005579 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 158878005580 HI0933-like protein; Region: HI0933_like; pfam03486 158878005581 Predicted flavoproteins [General function prediction only]; Region: COG2081 158878005582 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 158878005583 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 158878005584 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 158878005585 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005586 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005587 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005588 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005589 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005590 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005591 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005592 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005593 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005594 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005595 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005596 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005597 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005598 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005599 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878005600 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 158878005601 active site residue [active] 158878005602 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 158878005603 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 158878005604 HIGH motif; other site 158878005605 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 158878005606 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 158878005607 active site 158878005608 KMSKS motif; other site 158878005609 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 158878005610 tRNA binding surface [nucleotide binding]; other site 158878005611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878005612 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158878005613 putative substrate translocation pore; other site 158878005614 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 158878005615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878005616 S-adenosylmethionine binding site [chemical binding]; other site 158878005617 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 158878005618 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 158878005619 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 158878005620 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 158878005621 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 158878005622 homopentamer interface [polypeptide binding]; other site 158878005623 active site 158878005624 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 158878005625 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 158878005626 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 158878005627 dimerization interface [polypeptide binding]; other site 158878005628 active site 158878005629 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 158878005630 Lumazine binding domain; Region: Lum_binding; pfam00677 158878005631 Lumazine binding domain; Region: Lum_binding; pfam00677 158878005632 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 158878005633 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 158878005634 catalytic motif [active] 158878005635 Zn binding site [ion binding]; other site 158878005636 RibD C-terminal domain; Region: RibD_C; cl17279 158878005637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 158878005638 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 158878005639 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158878005640 dimerization interface [polypeptide binding]; other site 158878005641 putative DNA binding site [nucleotide binding]; other site 158878005642 putative Zn2+ binding site [ion binding]; other site 158878005643 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 158878005644 arsenical pump membrane protein; Provisional; Region: PRK15445 158878005645 transmembrane helices; other site 158878005646 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 158878005647 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 158878005648 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 158878005649 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 158878005650 DNA binding residues [nucleotide binding] 158878005651 CAAX protease self-immunity; Region: Abi; pfam02517 158878005652 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 158878005653 active site 158878005654 intersubunit interactions; other site 158878005655 catalytic residue [active] 158878005656 camphor resistance protein CrcB; Provisional; Region: PRK14201 158878005657 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 158878005658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 158878005659 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 158878005660 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 158878005661 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158878005662 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158878005663 active site 158878005664 catalytic tetrad [active] 158878005665 S-adenosylmethionine synthetase; Validated; Region: PRK05250 158878005666 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 158878005667 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 158878005668 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 158878005669 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 158878005670 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 158878005671 active site 158878005672 substrate-binding site [chemical binding]; other site 158878005673 metal-binding site [ion binding] 158878005674 ATP binding site [chemical binding]; other site 158878005675 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 158878005676 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 158878005677 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 158878005678 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 158878005679 nudix motif; other site 158878005680 Haemolytic domain; Region: Haemolytic; pfam01809 158878005681 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 158878005682 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 158878005683 metal binding site [ion binding]; metal-binding site 158878005684 substrate binding pocket [chemical binding]; other site 158878005685 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 158878005686 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 158878005687 acyl-activating enzyme (AAE) consensus motif; other site 158878005688 putative AMP binding site [chemical binding]; other site 158878005689 putative active site [active] 158878005690 putative CoA binding site [chemical binding]; other site 158878005691 Excalibur calcium-binding domain; Region: Excalibur; smart00894 158878005692 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 158878005693 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 158878005694 Integrase core domain; Region: rve; pfam00665 158878005695 DDE domain; Region: DDE_Tnp_IS240; pfam13610 158878005696 Integrase core domain; Region: rve_3; pfam13683 158878005697 putative transposase OrfB; Reviewed; Region: PHA02517 158878005698 Winged helix-turn helix; Region: HTH_29; pfam13551 158878005699 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 158878005700 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 158878005701 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 158878005702 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 158878005703 HsdM N-terminal domain; Region: HsdM_N; pfam12161 158878005704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878005705 S-adenosylmethionine binding site [chemical binding]; other site 158878005706 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 158878005707 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 158878005708 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 158878005709 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 158878005710 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 158878005711 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 158878005712 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 158878005713 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 158878005714 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 158878005715 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 158878005716 beta-channel forming cytolysin; Region: hlyII; TIGR01002 158878005717 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 158878005718 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 158878005719 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 158878005720 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 158878005721 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 158878005722 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 158878005723 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878005724 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 158878005725 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878005726 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878005727 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 158878005728 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 158878005729 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878005730 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 158878005731 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878005732 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 158878005733 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878005734 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 158878005735 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 158878005736 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 158878005737 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158878005738 ferrochelatase; Provisional; Region: PRK12435 158878005739 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 158878005740 C-terminal domain interface [polypeptide binding]; other site 158878005741 active site 158878005742 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 158878005743 active site 158878005744 N-terminal domain interface [polypeptide binding]; other site 158878005745 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 158878005746 substrate binding site [chemical binding]; other site 158878005747 active site 158878005748 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 158878005749 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 158878005750 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 158878005751 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158878005752 Walker A/P-loop; other site 158878005753 ATP binding site [chemical binding]; other site 158878005754 Q-loop/lid; other site 158878005755 ABC transporter signature motif; other site 158878005756 Walker B; other site 158878005757 D-loop; other site 158878005758 H-loop/switch region; other site 158878005759 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 158878005760 HIT family signature motif; other site 158878005761 catalytic residue [active] 158878005762 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 158878005763 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 158878005764 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 158878005765 SurA N-terminal domain; Region: SurA_N_3; cl07813 158878005766 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 158878005767 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 158878005768 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 158878005769 generic binding surface II; other site 158878005770 generic binding surface I; other site 158878005771 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158878005772 Zn2+ binding site [ion binding]; other site 158878005773 Mg2+ binding site [ion binding]; other site 158878005774 Uncharacterized conserved protein [Function unknown]; Region: COG4717 158878005775 P-loop containing region of AAA domain; Region: AAA_29; cl17516 158878005776 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 158878005777 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 158878005778 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 158878005779 active site 158878005780 metal binding site [ion binding]; metal-binding site 158878005781 DNA binding site [nucleotide binding] 158878005782 hypothetical protein; Provisional; Region: PRK13676 158878005783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 158878005784 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158878005785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878005786 non-specific DNA binding site [nucleotide binding]; other site 158878005787 salt bridge; other site 158878005788 sequence-specific DNA binding site [nucleotide binding]; other site 158878005789 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158878005790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878005791 active site 158878005792 phosphorylation site [posttranslational modification] 158878005793 intermolecular recognition site; other site 158878005794 dimerization interface [polypeptide binding]; other site 158878005795 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158878005796 DNA binding residues [nucleotide binding] 158878005797 dimerization interface [polypeptide binding]; other site 158878005798 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 158878005799 GAF domain; Region: GAF_3; pfam13492 158878005800 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 158878005801 Histidine kinase; Region: HisKA_3; pfam07730 158878005802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878005803 ATP binding site [chemical binding]; other site 158878005804 Mg2+ binding site [ion binding]; other site 158878005805 G-X-G motif; other site 158878005806 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 158878005807 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 158878005808 active site 158878005809 fumarate hydratase; Reviewed; Region: fumC; PRK00485 158878005810 Class II fumarases; Region: Fumarase_classII; cd01362 158878005811 active site 158878005812 tetramer interface [polypeptide binding]; other site 158878005813 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 158878005814 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 158878005815 active site 158878005816 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 158878005817 epoxyqueuosine reductase; Region: TIGR00276 158878005818 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 158878005819 HEAT repeats; Region: HEAT_2; pfam13646 158878005820 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 158878005821 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 158878005822 Walker A/P-loop; other site 158878005823 ATP binding site [chemical binding]; other site 158878005824 Q-loop/lid; other site 158878005825 ABC transporter signature motif; other site 158878005826 Walker B; other site 158878005827 D-loop; other site 158878005828 H-loop/switch region; other site 158878005829 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158878005830 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158878005831 substrate binding pocket [chemical binding]; other site 158878005832 membrane-bound complex binding site; other site 158878005833 hinge residues; other site 158878005834 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 158878005835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878005836 dimer interface [polypeptide binding]; other site 158878005837 conserved gate region; other site 158878005838 putative PBP binding loops; other site 158878005839 ABC-ATPase subunit interface; other site 158878005840 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 158878005841 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 158878005842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 158878005843 Transposase; Region: DDE_Tnp_ISL3; pfam01610 158878005844 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 158878005845 metal binding site 2 [ion binding]; metal-binding site 158878005846 putative DNA binding helix; other site 158878005847 metal binding site 1 [ion binding]; metal-binding site 158878005848 dimer interface [polypeptide binding]; other site 158878005849 structural Zn2+ binding site [ion binding]; other site 158878005850 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 158878005851 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 158878005852 putative ligand binding site [chemical binding]; other site 158878005853 NAD binding site [chemical binding]; other site 158878005854 catalytic site [active] 158878005855 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 158878005856 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 158878005857 catalytic triad [active] 158878005858 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 158878005859 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 158878005860 inhibitor-cofactor binding pocket; inhibition site 158878005861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878005862 catalytic residue [active] 158878005863 Predicted membrane protein [Function unknown]; Region: COG4129 158878005864 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 158878005865 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 158878005866 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 158878005867 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 158878005868 Walker A/P-loop; other site 158878005869 ATP binding site [chemical binding]; other site 158878005870 Q-loop/lid; other site 158878005871 ABC transporter signature motif; other site 158878005872 Walker B; other site 158878005873 D-loop; other site 158878005874 H-loop/switch region; other site 158878005875 hypothetical protein; Provisional; Region: PRK13662 158878005876 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 158878005877 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 158878005878 minor groove reading motif; other site 158878005879 helix-hairpin-helix signature motif; other site 158878005880 substrate binding pocket [chemical binding]; other site 158878005881 active site 158878005882 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 158878005883 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 158878005884 DNA binding and oxoG recognition site [nucleotide binding] 158878005885 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 158878005886 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 158878005887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158878005888 Walker A/P-loop; other site 158878005889 ATP binding site [chemical binding]; other site 158878005890 Q-loop/lid; other site 158878005891 ABC transporter signature motif; other site 158878005892 Walker B; other site 158878005893 H-loop/switch region; other site 158878005894 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 158878005895 recombination regulator RecX; Provisional; Region: recX; PRK14135 158878005896 glycosyltransferase; Provisional; Region: PRK13481 158878005897 Transglycosylase; Region: Transgly; pfam00912 158878005898 intracellular protease, PfpI family; Region: PfpI; TIGR01382 158878005899 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 158878005900 proposed catalytic triad [active] 158878005901 conserved cys residue [active] 158878005902 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 158878005903 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158878005904 FeS/SAM binding site; other site 158878005905 YfkB-like domain; Region: YfkB; pfam08756 158878005906 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 158878005907 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 158878005908 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 158878005909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 158878005910 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 158878005911 Low molecular weight phosphatase family; Region: LMWPc; cd00115 158878005912 active site 158878005913 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 158878005914 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158878005915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878005916 active site 158878005917 phosphorylation site [posttranslational modification] 158878005918 intermolecular recognition site; other site 158878005919 dimerization interface [polypeptide binding]; other site 158878005920 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158878005921 DNA binding residues [nucleotide binding] 158878005922 dimerization interface [polypeptide binding]; other site 158878005923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 158878005924 Histidine kinase; Region: HisKA_3; pfam07730 158878005925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878005926 ATP binding site [chemical binding]; other site 158878005927 Mg2+ binding site [ion binding]; other site 158878005928 G-X-G motif; other site 158878005929 Predicted membrane protein [Function unknown]; Region: COG4758 158878005930 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 158878005931 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 158878005932 active site 158878005933 Predicted membrane protein [Function unknown]; Region: COG4129 158878005934 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 158878005935 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 158878005936 catalytic triad [active] 158878005937 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 158878005938 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 158878005939 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 158878005940 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 158878005941 Ferritin-like domain; Region: Ferritin; pfam00210 158878005942 ferroxidase diiron center [ion binding]; other site 158878005943 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 158878005944 active site 158878005945 catalytic site [active] 158878005946 substrate binding site [chemical binding]; other site 158878005947 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 158878005948 active site 158878005949 DNA polymerase IV; Validated; Region: PRK02406 158878005950 DNA binding site [nucleotide binding] 158878005951 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 158878005952 TRAM domain; Region: TRAM; cl01282 158878005953 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 158878005954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878005955 S-adenosylmethionine binding site [chemical binding]; other site 158878005956 putative lipid kinase; Reviewed; Region: PRK13337 158878005957 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 158878005958 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 158878005959 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 158878005960 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 158878005961 GatB domain; Region: GatB_Yqey; pfam02637 158878005962 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 158878005963 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 158878005964 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 158878005965 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 158878005966 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 158878005967 Na binding site [ion binding]; other site 158878005968 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 158878005969 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 158878005970 putative dimer interface [polypeptide binding]; other site 158878005971 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 158878005972 putative dimer interface [polypeptide binding]; other site 158878005973 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 158878005974 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 158878005975 nucleotide binding pocket [chemical binding]; other site 158878005976 K-X-D-G motif; other site 158878005977 catalytic site [active] 158878005978 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 158878005979 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 158878005980 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 158878005981 Dimer interface [polypeptide binding]; other site 158878005982 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 158878005983 Part of AAA domain; Region: AAA_19; pfam13245 158878005984 Family description; Region: UvrD_C_2; pfam13538 158878005985 PcrB family; Region: PcrB; pfam01884 158878005986 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 158878005987 substrate binding site [chemical binding]; other site 158878005988 putative active site [active] 158878005989 dimer interface [polypeptide binding]; other site 158878005990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 158878005991 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 158878005992 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 158878005993 tetramer interface [polypeptide binding]; other site 158878005994 active site 158878005995 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 158878005996 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 158878005997 Staphostatin A; Region: Staphostatin_A; pfam09022 158878005998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 158878005999 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 158878006000 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 158878006001 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 158878006002 homodimer interface [polypeptide binding]; other site 158878006003 NAD binding pocket [chemical binding]; other site 158878006004 ATP binding pocket [chemical binding]; other site 158878006005 Mg binding site [ion binding]; other site 158878006006 active-site loop [active] 158878006007 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 158878006008 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 158878006009 active site 158878006010 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 158878006011 active site 158878006012 dimer interface [polypeptide binding]; other site 158878006013 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 158878006014 Prephenate dehydratase; Region: PDT; pfam00800 158878006015 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 158878006016 putative L-Phe binding site [chemical binding]; other site 158878006017 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 158878006018 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 158878006019 transmembrane helices; other site 158878006020 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 158878006021 Isochorismatase family; Region: Isochorismatase; pfam00857 158878006022 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 158878006023 catalytic triad [active] 158878006024 conserved cis-peptide bond; other site 158878006025 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 158878006026 DHH family; Region: DHH; pfam01368 158878006027 DHHA2 domain; Region: DHHA2; pfam02833 158878006028 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 158878006029 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 158878006030 NAD(P) binding site [chemical binding]; other site 158878006031 catalytic residues [active] 158878006032 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 158878006033 YolD-like protein; Region: YolD; pfam08863 158878006034 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 158878006035 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 158878006036 active site 158878006037 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 158878006038 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 158878006039 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 158878006040 Bacterial PH domain; Region: DUF304; cl01348 158878006041 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 158878006042 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 158878006043 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158878006044 Walker A/P-loop; other site 158878006045 ATP binding site [chemical binding]; other site 158878006046 Q-loop/lid; other site 158878006047 ABC transporter signature motif; other site 158878006048 Walker B; other site 158878006049 D-loop; other site 158878006050 H-loop/switch region; other site 158878006051 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 158878006052 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 158878006053 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158878006054 Walker A/P-loop; other site 158878006055 ATP binding site [chemical binding]; other site 158878006056 Q-loop/lid; other site 158878006057 ABC transporter signature motif; other site 158878006058 Walker B; other site 158878006059 D-loop; other site 158878006060 H-loop/switch region; other site 158878006061 Predicted transcriptional regulators [Transcription]; Region: COG1725 158878006062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158878006063 DNA-binding site [nucleotide binding]; DNA binding site 158878006064 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 158878006065 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158878006066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878006067 homodimer interface [polypeptide binding]; other site 158878006068 catalytic residue [active] 158878006069 Bacteriophage phi Sa 3mu 158878006070 MAP domain; Region: MAP; pfam03642 158878006071 MAP domain; Region: MAP; pfam03642 158878006072 MAP domain; Region: MAP; pfam03642 158878006073 MAP domain; Region: MAP; pfam03642 158878006074 MAP domain; Region: MAP; pfam03642 158878006075 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 158878006076 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 158878006077 truncated amidase 158878006078 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 158878006079 CHAP domain; Region: CHAP; pfam05257 158878006080 Small integral membrane protein [Function unknown]; Region: COG5546 158878006081 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 158878006082 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878006083 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 158878006084 Ligand-gated ion channel; Region: Lig_chan; pfam00060 158878006085 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 158878006086 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 158878006087 Phage tail protein; Region: Sipho_tail; cl17486 158878006088 Phage tail protein; Region: Sipho_tail; cl17486 158878006089 Phage-related minor tail protein [Function unknown]; Region: COG5280 158878006090 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 158878006091 Phage-related protein [Function unknown]; Region: COG5412 158878006092 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 158878006093 Peptidase family M23; Region: Peptidase_M23; pfam01551 158878006094 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 158878006095 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 158878006096 N-acetyl-D-glucosamine binding site [chemical binding]; other site 158878006097 catalytic residue [active] 158878006098 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 158878006099 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 158878006100 Translocation protein Sec62; Region: Sec62; cl02170 158878006101 Phage capsid family; Region: Phage_capsid; pfam05065 158878006102 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 158878006103 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 158878006104 oligomer interface [polypeptide binding]; other site 158878006105 active site residues [active] 158878006106 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 158878006107 Phage-related protein [Function unknown]; Region: COG4695; cl01923 158878006108 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 158878006109 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 158878006110 HNH endonuclease; Region: HNH; pfam01844 158878006111 active site 158878006112 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 158878006113 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 158878006114 Transcriptional activator RinB; Region: RinB; pfam06116 158878006115 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 158878006116 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 158878006117 trimer interface [polypeptide binding]; other site 158878006118 active site 158878006119 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 158878006120 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 158878006121 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 158878006122 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 158878006123 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 158878006124 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 158878006125 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 158878006126 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 158878006127 dimer interface [polypeptide binding]; other site 158878006128 ssDNA binding site [nucleotide binding]; other site 158878006129 tetramer (dimer of dimers) interface [polypeptide binding]; other site 158878006130 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 158878006131 RecT family; Region: RecT; pfam03837 158878006132 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 158878006133 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 158878006134 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 158878006135 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 158878006136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 158878006137 Phage anti-repressor protein [Transcription]; Region: COG3561 158878006138 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 158878006139 Protein of unknown function (DUF739); Region: DUF739; pfam05339 158878006140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878006141 non-specific DNA binding site [nucleotide binding]; other site 158878006142 salt bridge; other site 158878006143 sequence-specific DNA binding site [nucleotide binding]; other site 158878006144 Predicted transcriptional regulator [Transcription]; Region: COG2932 158878006145 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 158878006146 Catalytic site [active] 158878006147 HIRAN domain; Region: HIRAN; pfam08797 158878006148 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 158878006149 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 158878006150 Int/Topo IB signature motif; other site 158878006151 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 158878006152 putative catalytic site [active] 158878006153 phosphate binding site [ion binding]; other site 158878006154 metal binding site A [ion binding]; metal-binding site 158878006155 metal binding site C [ion binding]; metal-binding site 158878006156 metal binding site B [ion binding]; metal-binding site 158878006157 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 158878006158 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 158878006159 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 158878006160 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 158878006161 metal binding site [ion binding]; metal-binding site 158878006162 dimer interface [polypeptide binding]; other site 158878006163 Cation transport protein; Region: TrkH; cl17365 158878006164 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 158878006165 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 158878006166 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878006167 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 158878006168 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878006169 superantigen-like protein; Reviewed; Region: PRK13350 158878006170 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 158878006171 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 158878006172 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 158878006173 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 158878006174 hydrolase, hydrolyzing O-glycosyl compounds; Region: PLN02219; cl14104 158878006175 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 158878006176 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 158878006177 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 158878006178 DNA binding domain, excisionase family; Region: excise; TIGR01764 158878006179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878006180 non-specific DNA binding site [nucleotide binding]; other site 158878006181 salt bridge; other site 158878006182 sequence-specific DNA binding site [nucleotide binding]; other site 158878006183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878006184 non-specific DNA binding site [nucleotide binding]; other site 158878006185 salt bridge; other site 158878006186 sequence-specific DNA binding site [nucleotide binding]; other site 158878006187 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 158878006188 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 158878006189 Int/Topo IB signature motif; other site 158878006190 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 158878006191 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 158878006192 ring oligomerisation interface [polypeptide binding]; other site 158878006193 ATP/Mg binding site [chemical binding]; other site 158878006194 stacking interactions; other site 158878006195 hinge regions; other site 158878006196 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 158878006197 oligomerisation interface [polypeptide binding]; other site 158878006198 mobile loop; other site 158878006199 roof hairpin; other site 158878006200 CAAX protease self-immunity; Region: Abi; pfam02517 158878006201 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 158878006202 dimer interface [polypeptide binding]; other site 158878006203 FMN binding site [chemical binding]; other site 158878006204 Predicted amidohydrolase [General function prediction only]; Region: COG0388 158878006205 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 158878006206 putative active site [active] 158878006207 catalytic triad [active] 158878006208 putative dimer interface [polypeptide binding]; other site 158878006209 delta-hemolysin; Provisional; Region: PRK14752 158878006210 Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription]; Region: AgrB; COG4512 158878006211 Staphylococcal AgrD protein; Region: AgrD; pfam05931 158878006212 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 158878006213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878006214 Mg2+ binding site [ion binding]; other site 158878006215 G-X-G motif; other site 158878006216 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 158878006217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878006218 active site 158878006219 phosphorylation site [posttranslational modification] 158878006220 intermolecular recognition site; other site 158878006221 dimerization interface [polypeptide binding]; other site 158878006222 LytTr DNA-binding domain; Region: LytTR; pfam04397 158878006223 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158878006224 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 158878006225 putative substrate binding site [chemical binding]; other site 158878006226 putative ATP binding site [chemical binding]; other site 158878006227 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 158878006228 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 158878006229 substrate binding [chemical binding]; other site 158878006230 active site 158878006231 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 158878006232 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158878006233 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158878006234 DNA binding site [nucleotide binding] 158878006235 domain linker motif; other site 158878006236 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 158878006237 dimerization interface [polypeptide binding]; other site 158878006238 ligand binding site [chemical binding]; other site 158878006239 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 158878006240 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 158878006241 CPxP motif; other site 158878006242 Predicted transporter component [General function prediction only]; Region: COG2391 158878006243 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 158878006244 Sulphur transport; Region: Sulf_transp; pfam04143 158878006245 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 158878006246 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 158878006247 CoA binding domain; Region: CoA_binding; pfam02629 158878006248 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 158878006249 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158878006250 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158878006251 ABC transporter; Region: ABC_tran_2; pfam12848 158878006252 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158878006253 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 158878006254 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 158878006255 Walker A/P-loop; other site 158878006256 ATP binding site [chemical binding]; other site 158878006257 Q-loop/lid; other site 158878006258 ABC transporter signature motif; other site 158878006259 Walker B; other site 158878006260 D-loop; other site 158878006261 H-loop/switch region; other site 158878006262 UGMP family protein; Validated; Region: PRK09604 158878006263 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 158878006264 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 158878006265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878006266 Coenzyme A binding pocket [chemical binding]; other site 158878006267 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 158878006268 Glycoprotease family; Region: Peptidase_M22; pfam00814 158878006269 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 158878006270 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 158878006271 6-phosphogluconate dehydratase; Region: edd; TIGR01196 158878006272 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 158878006273 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 158878006274 PYR/PP interface [polypeptide binding]; other site 158878006275 dimer interface [polypeptide binding]; other site 158878006276 TPP binding site [chemical binding]; other site 158878006277 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 158878006278 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 158878006279 TPP-binding site [chemical binding]; other site 158878006280 dimer interface [polypeptide binding]; other site 158878006281 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 158878006282 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 158878006283 ketol-acid reductoisomerase; Provisional; Region: PRK05479 158878006284 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 158878006285 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 158878006286 2-isopropylmalate synthase; Validated; Region: PRK00915 158878006287 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 158878006288 active site 158878006289 catalytic residues [active] 158878006290 metal binding site [ion binding]; metal-binding site 158878006291 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 158878006292 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 158878006293 tartrate dehydrogenase; Region: TTC; TIGR02089 158878006294 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 158878006295 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 158878006296 substrate binding site [chemical binding]; other site 158878006297 ligand binding site [chemical binding]; other site 158878006298 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 158878006299 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 158878006300 substrate binding site [chemical binding]; other site 158878006301 threonine dehydratase; Validated; Region: PRK08639 158878006302 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 158878006303 tetramer interface [polypeptide binding]; other site 158878006304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878006305 catalytic residue [active] 158878006306 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 158878006307 putative Ile/Val binding site [chemical binding]; other site 158878006308 hypothetical protein; Provisional; Region: PRK04351 158878006309 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 158878006310 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 158878006311 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 158878006312 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 158878006313 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 158878006314 RNA binding site [nucleotide binding]; other site 158878006315 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 158878006316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 158878006317 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 158878006318 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 158878006319 DNA binding residues [nucleotide binding] 158878006320 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 158878006321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878006322 ATP binding site [chemical binding]; other site 158878006323 Mg2+ binding site [ion binding]; other site 158878006324 G-X-G motif; other site 158878006325 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 158878006326 anti sigma factor interaction site; other site 158878006327 regulatory phosphorylation site [posttranslational modification]; other site 158878006328 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 158878006329 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 158878006330 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 158878006331 PemK-like protein; Region: PemK; pfam02452 158878006332 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 158878006333 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 158878006334 active site 158878006335 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158878006336 dimer interface [polypeptide binding]; other site 158878006337 substrate binding site [chemical binding]; other site 158878006338 catalytic residues [active] 158878006339 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 158878006340 Uncharacterized conserved protein [Function unknown]; Region: COG3402 158878006341 Predicted membrane protein [Function unknown]; Region: COG3428 158878006342 Bacterial PH domain; Region: DUF304; pfam03703 158878006343 Bacterial PH domain; Region: DUF304; pfam03703 158878006344 Bacterial PH domain; Region: DUF304; cl01348 158878006345 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 158878006346 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 158878006347 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 158878006348 Soluble P-type ATPase [General function prediction only]; Region: COG4087 158878006349 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 158878006350 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 158878006351 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 158878006352 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 158878006353 Ligand Binding Site [chemical binding]; other site 158878006354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158878006355 dimer interface [polypeptide binding]; other site 158878006356 phosphorylation site [posttranslational modification] 158878006357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878006358 ATP binding site [chemical binding]; other site 158878006359 Mg2+ binding site [ion binding]; other site 158878006360 G-X-G motif; other site 158878006361 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158878006362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878006363 active site 158878006364 phosphorylation site [posttranslational modification] 158878006365 intermolecular recognition site; other site 158878006366 dimerization interface [polypeptide binding]; other site 158878006367 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158878006368 DNA binding site [nucleotide binding] 158878006369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 158878006370 Transposase; Region: DDE_Tnp_ISL3; pfam01610 158878006371 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 158878006372 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 158878006373 ATP binding site [chemical binding]; other site 158878006374 Mg++ binding site [ion binding]; other site 158878006375 motif III; other site 158878006376 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158878006377 nucleotide binding region [chemical binding]; other site 158878006378 ATP-binding site [chemical binding]; other site 158878006379 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 158878006380 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 158878006381 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 158878006382 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 158878006383 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 158878006384 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 158878006385 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 158878006386 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 158878006387 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 158878006388 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 158878006389 putative homodimer interface [polypeptide binding]; other site 158878006390 putative homotetramer interface [polypeptide binding]; other site 158878006391 allosteric switch controlling residues; other site 158878006392 putative metal binding site [ion binding]; other site 158878006393 putative homodimer-homodimer interface [polypeptide binding]; other site 158878006394 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 158878006395 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 158878006396 putative active site [active] 158878006397 catalytic site [active] 158878006398 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 158878006399 putative active site [active] 158878006400 catalytic site [active] 158878006401 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 158878006402 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158878006403 Zn2+ binding site [ion binding]; other site 158878006404 Mg2+ binding site [ion binding]; other site 158878006405 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 158878006406 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 158878006407 thiamine phosphate binding site [chemical binding]; other site 158878006408 active site 158878006409 pyrophosphate binding site [ion binding]; other site 158878006410 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 158878006411 substrate binding site [chemical binding]; other site 158878006412 multimerization interface [polypeptide binding]; other site 158878006413 ATP binding site [chemical binding]; other site 158878006414 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 158878006415 dimer interface [polypeptide binding]; other site 158878006416 substrate binding site [chemical binding]; other site 158878006417 ATP binding site [chemical binding]; other site 158878006418 thiaminase II; Region: salvage_TenA; TIGR04306 158878006419 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 158878006420 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 158878006421 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 158878006422 dimer interface [polypeptide binding]; other site 158878006423 ssDNA binding site [nucleotide binding]; other site 158878006424 tetramer (dimer of dimers) interface [polypeptide binding]; other site 158878006425 YwpF-like protein; Region: YwpF; pfam14183 158878006426 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 158878006427 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 158878006428 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 158878006429 hinge; other site 158878006430 active site 158878006431 Predicted membrane protein [Function unknown]; Region: COG4836 158878006432 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 158878006433 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 158878006434 gamma subunit interface [polypeptide binding]; other site 158878006435 epsilon subunit interface [polypeptide binding]; other site 158878006436 LBP interface [polypeptide binding]; other site 158878006437 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 158878006438 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 158878006439 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 158878006440 alpha subunit interaction interface [polypeptide binding]; other site 158878006441 Walker A motif; other site 158878006442 ATP binding site [chemical binding]; other site 158878006443 Walker B motif; other site 158878006444 inhibitor binding site; inhibition site 158878006445 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 158878006446 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 158878006447 core domain interface [polypeptide binding]; other site 158878006448 delta subunit interface [polypeptide binding]; other site 158878006449 epsilon subunit interface [polypeptide binding]; other site 158878006450 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 158878006451 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 158878006452 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 158878006453 beta subunit interaction interface [polypeptide binding]; other site 158878006454 Walker A motif; other site 158878006455 ATP binding site [chemical binding]; other site 158878006456 Walker B motif; other site 158878006457 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 158878006458 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 158878006459 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 158878006460 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 158878006461 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 158878006462 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 158878006463 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 158878006464 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 158878006465 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 158878006466 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 158878006467 active site 158878006468 homodimer interface [polypeptide binding]; other site 158878006469 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158878006470 active site 158878006471 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 158878006472 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 158878006473 dimer interface [polypeptide binding]; other site 158878006474 active site 158878006475 glycine-pyridoxal phosphate binding site [chemical binding]; other site 158878006476 folate binding site [chemical binding]; other site 158878006477 hypothetical protein; Provisional; Region: PRK13690 158878006478 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 158878006479 Low molecular weight phosphatase family; Region: LMWPc; cd00115 158878006480 active site 158878006481 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 158878006482 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 158878006483 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 158878006484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878006485 S-adenosylmethionine binding site [chemical binding]; other site 158878006486 peptide chain release factor 1; Validated; Region: prfA; PRK00591 158878006487 This domain is found in peptide chain release factors; Region: PCRF; smart00937 158878006488 RF-1 domain; Region: RF-1; pfam00472 158878006489 thymidine kinase; Provisional; Region: PRK04296 158878006490 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 158878006491 transcription termination factor Rho; Provisional; Region: rho; PRK09376 158878006492 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 158878006493 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 158878006494 RNA binding site [nucleotide binding]; other site 158878006495 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 158878006496 multimer interface [polypeptide binding]; other site 158878006497 Walker A motif; other site 158878006498 ATP binding site [chemical binding]; other site 158878006499 Walker B motif; other site 158878006500 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 158878006501 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 158878006502 NAD binding site [chemical binding]; other site 158878006503 catalytic residues [active] 158878006504 Predicted transcriptional regulators [Transcription]; Region: COG1733 158878006505 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 158878006506 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 158878006507 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 158878006508 hinge; other site 158878006509 active site 158878006510 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 158878006511 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 158878006512 intersubunit interface [polypeptide binding]; other site 158878006513 active site 158878006514 zinc binding site [ion binding]; other site 158878006515 Na+ binding site [ion binding]; other site 158878006516 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 158878006517 CTP synthetase; Validated; Region: pyrG; PRK05380 158878006518 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 158878006519 Catalytic site [active] 158878006520 active site 158878006521 UTP binding site [chemical binding]; other site 158878006522 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 158878006523 active site 158878006524 putative oxyanion hole; other site 158878006525 catalytic triad [active] 158878006526 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 158878006527 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878006528 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 158878006529 Coenzyme A binding pocket [chemical binding]; other site 158878006530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158878006531 Coenzyme A binding pocket [chemical binding]; other site 158878006532 pantothenate kinase; Provisional; Region: PRK13317 158878006533 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 158878006534 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 158878006535 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 158878006536 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 158878006537 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 158878006538 metal binding site [ion binding]; metal-binding site 158878006539 S-ribosylhomocysteinase; Provisional; Region: PRK02260 158878006540 Predicted membrane protein [Function unknown]; Region: COG4270 158878006541 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 158878006542 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 158878006543 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 158878006544 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 158878006545 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 158878006546 intersubunit interface [polypeptide binding]; other site 158878006547 active site 158878006548 catalytic residue [active] 158878006549 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 158878006550 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 158878006551 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 158878006552 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 158878006553 dimerization interface [polypeptide binding]; other site 158878006554 DPS ferroxidase diiron center [ion binding]; other site 158878006555 ion pore; other site 158878006556 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 158878006557 EVE domain; Region: EVE; cl00728 158878006558 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 158878006559 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 158878006560 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 158878006561 NADH(P)-binding; Region: NAD_binding_10; pfam13460 158878006562 NAD(P) binding site [chemical binding]; other site 158878006563 putative active site [active] 158878006564 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158878006565 dimerization interface [polypeptide binding]; other site 158878006566 putative DNA binding site [nucleotide binding]; other site 158878006567 putative Zn2+ binding site [ion binding]; other site 158878006568 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 158878006569 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 158878006570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 158878006571 Cytoadherence-linked asexual protein; Region: CLAG; pfam03805 158878006572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 158878006573 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 158878006574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878006575 active site 158878006576 motif I; other site 158878006577 motif II; other site 158878006578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878006579 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 158878006580 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158878006581 Walker A/P-loop; other site 158878006582 ATP binding site [chemical binding]; other site 158878006583 Q-loop/lid; other site 158878006584 ABC transporter signature motif; other site 158878006585 Walker B; other site 158878006586 D-loop; other site 158878006587 H-loop/switch region; other site 158878006588 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 158878006589 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 158878006590 glutaminase active site [active] 158878006591 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 158878006592 dimer interface [polypeptide binding]; other site 158878006593 active site 158878006594 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 158878006595 dimer interface [polypeptide binding]; other site 158878006596 active site 158878006597 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 158878006598 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 158878006599 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 158878006600 active site 158878006601 P-loop; other site 158878006602 phosphorylation site [posttranslational modification] 158878006603 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 158878006604 HTH domain; Region: HTH_11; pfam08279 158878006605 Mga helix-turn-helix domain; Region: Mga; pfam05043 158878006606 PRD domain; Region: PRD; pfam00874 158878006607 PRD domain; Region: PRD; pfam00874 158878006608 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 158878006609 active site 158878006610 P-loop; other site 158878006611 phosphorylation site [posttranslational modification] 158878006612 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 158878006613 active site 158878006614 phosphorylation site [posttranslational modification] 158878006615 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158878006616 active site 158878006617 phosphorylation site [posttranslational modification] 158878006618 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 158878006619 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 158878006620 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 158878006621 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 158878006622 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 158878006623 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878006624 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878006625 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878006626 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878006627 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878006628 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878006629 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 158878006630 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 158878006631 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 158878006632 active site 158878006633 substrate binding site [chemical binding]; other site 158878006634 metal binding site [ion binding]; metal-binding site 158878006635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 158878006636 YbbR-like protein; Region: YbbR; pfam07949 158878006637 TIGR00159 family protein; Region: TIGR00159 158878006638 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 158878006639 Arginase family; Region: Arginase; cd09989 158878006640 active site 158878006641 Mn binding site [ion binding]; other site 158878006642 oligomer interface [polypeptide binding]; other site 158878006643 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 158878006644 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 158878006645 Walker A motif; other site 158878006646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878006647 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158878006648 putative substrate translocation pore; other site 158878006649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878006650 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 158878006651 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 158878006652 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 158878006653 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 158878006654 substrate binding site; other site 158878006655 dimerization interface; other site 158878006656 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 158878006657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 158878006658 Nucleoside recognition; Region: Gate; pfam07670 158878006659 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 158878006660 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158878006661 ABC-ATPase subunit interface; other site 158878006662 dimer interface [polypeptide binding]; other site 158878006663 putative PBP binding regions; other site 158878006664 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 158878006665 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158878006666 ABC-ATPase subunit interface; other site 158878006667 dimer interface [polypeptide binding]; other site 158878006668 putative PBP binding regions; other site 158878006669 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 158878006670 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 158878006671 siderophore binding site; other site 158878006672 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 158878006673 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 158878006674 dimer interface [polypeptide binding]; other site 158878006675 active site 158878006676 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158878006677 substrate binding site [chemical binding]; other site 158878006678 catalytic residue [active] 158878006679 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 158878006680 IucA / IucC family; Region: IucA_IucC; pfam04183 158878006681 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 158878006682 H+ Antiporter protein; Region: 2A0121; TIGR00900 158878006683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878006684 putative substrate translocation pore; other site 158878006685 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 158878006686 IucA / IucC family; Region: IucA_IucC; pfam04183 158878006687 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 158878006688 Asp23 family; Region: Asp23; pfam03780 158878006689 Small integral membrane protein [Function unknown]; Region: COG5547 158878006690 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 158878006691 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 158878006692 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 158878006693 putative NAD(P) binding site [chemical binding]; other site 158878006694 dimer interface [polypeptide binding]; other site 158878006695 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 158878006696 Prostaglandin dehydrogenases; Region: PGDH; cd05288 158878006697 NAD(P) binding site [chemical binding]; other site 158878006698 substrate binding site [chemical binding]; other site 158878006699 dimer interface [polypeptide binding]; other site 158878006700 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 158878006701 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 158878006702 beta-galactosidase; Region: BGL; TIGR03356 158878006703 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 158878006704 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 158878006705 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 158878006706 active site 158878006707 P-loop; other site 158878006708 phosphorylation site [posttranslational modification] 158878006709 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 158878006710 methionine cluster; other site 158878006711 active site 158878006712 phosphorylation site [posttranslational modification] 158878006713 metal binding site [ion binding]; metal-binding site 158878006714 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 158878006715 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 158878006716 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 158878006717 putative substrate binding site [chemical binding]; other site 158878006718 putative ATP binding site [chemical binding]; other site 158878006719 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 158878006720 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 158878006721 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 158878006722 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 158878006723 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 158878006724 NAD-dependent deacetylase; Provisional; Region: PRK00481 158878006725 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 158878006726 NAD+ binding site [chemical binding]; other site 158878006727 substrate binding site [chemical binding]; other site 158878006728 putative Zn binding site [ion binding]; other site 158878006729 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158878006730 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158878006731 active site 158878006732 catalytic tetrad [active] 158878006733 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 158878006734 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 158878006735 DNA binding residues [nucleotide binding] 158878006736 putative dimer interface [polypeptide binding]; other site 158878006737 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 158878006738 substrate binding site [chemical binding]; other site 158878006739 catalytic residues [active] 158878006740 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 158878006741 Peptidase family M23; Region: Peptidase_M23; pfam01551 158878006742 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 158878006743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 158878006744 active site 158878006745 motif I; other site 158878006746 motif II; other site 158878006747 MAP domain; Region: MAP; pfam03642 158878006748 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 158878006749 acetolactate synthase; Reviewed; Region: PRK08617 158878006750 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 158878006751 PYR/PP interface [polypeptide binding]; other site 158878006752 dimer interface [polypeptide binding]; other site 158878006753 TPP binding site [chemical binding]; other site 158878006754 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 158878006755 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 158878006756 TPP-binding site [chemical binding]; other site 158878006757 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 158878006758 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 158878006759 putative active site [active] 158878006760 putative NTP binding site [chemical binding]; other site 158878006761 putative nucleic acid binding site [nucleotide binding]; other site 158878006762 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 158878006763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 158878006764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 158878006765 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 158878006766 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 158878006767 23S rRNA interface [nucleotide binding]; other site 158878006768 L3 interface [polypeptide binding]; other site 158878006769 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 158878006770 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 158878006771 dimerization interface 3.5A [polypeptide binding]; other site 158878006772 active site 158878006773 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 158878006774 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 158878006775 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158878006776 Walker A/P-loop; other site 158878006777 ATP binding site [chemical binding]; other site 158878006778 Q-loop/lid; other site 158878006779 ABC transporter signature motif; other site 158878006780 Walker B; other site 158878006781 D-loop; other site 158878006782 H-loop/switch region; other site 158878006783 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 158878006784 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158878006785 Walker A/P-loop; other site 158878006786 ATP binding site [chemical binding]; other site 158878006787 Q-loop/lid; other site 158878006788 ABC transporter signature motif; other site 158878006789 Walker B; other site 158878006790 D-loop; other site 158878006791 H-loop/switch region; other site 158878006792 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 158878006793 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 158878006794 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 158878006795 alphaNTD homodimer interface [polypeptide binding]; other site 158878006796 alphaNTD - beta interaction site [polypeptide binding]; other site 158878006797 alphaNTD - beta' interaction site [polypeptide binding]; other site 158878006798 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 158878006799 30S ribosomal protein S11; Validated; Region: PRK05309 158878006800 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 158878006801 30S ribosomal protein S13; Region: bact_S13; TIGR03631 158878006802 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 158878006803 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 158878006804 rRNA binding site [nucleotide binding]; other site 158878006805 predicted 30S ribosome binding site; other site 158878006806 adenylate kinase; Reviewed; Region: adk; PRK00279 158878006807 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 158878006808 AMP-binding site [chemical binding]; other site 158878006809 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 158878006810 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 158878006811 SecY translocase; Region: SecY; pfam00344 158878006812 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 158878006813 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 158878006814 23S rRNA binding site [nucleotide binding]; other site 158878006815 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 158878006816 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 158878006817 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 158878006818 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 158878006819 5S rRNA interface [nucleotide binding]; other site 158878006820 L27 interface [polypeptide binding]; other site 158878006821 23S rRNA interface [nucleotide binding]; other site 158878006822 L5 interface [polypeptide binding]; other site 158878006823 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 158878006824 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 158878006825 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 158878006826 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 158878006827 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 158878006828 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 158878006829 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 158878006830 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 158878006831 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 158878006832 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 158878006833 RNA binding site [nucleotide binding]; other site 158878006834 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 158878006835 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 158878006836 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 158878006837 23S rRNA interface [nucleotide binding]; other site 158878006838 putative translocon interaction site; other site 158878006839 signal recognition particle (SRP54) interaction site; other site 158878006840 L23 interface [polypeptide binding]; other site 158878006841 trigger factor interaction site; other site 158878006842 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 158878006843 23S rRNA interface [nucleotide binding]; other site 158878006844 5S rRNA interface [nucleotide binding]; other site 158878006845 putative antibiotic binding site [chemical binding]; other site 158878006846 L25 interface [polypeptide binding]; other site 158878006847 L27 interface [polypeptide binding]; other site 158878006848 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 158878006849 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 158878006850 G-X-X-G motif; other site 158878006851 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 158878006852 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 158878006853 putative translocon binding site; other site 158878006854 protein-rRNA interface [nucleotide binding]; other site 158878006855 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 158878006856 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 158878006857 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 158878006858 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 158878006859 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 158878006860 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 158878006861 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 158878006862 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 158878006863 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 158878006864 DNA topoisomerase III; Provisional; Region: PRK07726 158878006865 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 158878006866 active site 158878006867 putative interdomain interaction site [polypeptide binding]; other site 158878006868 putative metal-binding site [ion binding]; other site 158878006869 putative nucleotide binding site [chemical binding]; other site 158878006870 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 158878006871 domain I; other site 158878006872 DNA binding groove [nucleotide binding] 158878006873 phosphate binding site [ion binding]; other site 158878006874 domain II; other site 158878006875 domain III; other site 158878006876 nucleotide binding site [chemical binding]; other site 158878006877 catalytic site [active] 158878006878 domain IV; other site 158878006879 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 158878006880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878006881 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 158878006882 Coenzyme A binding pocket [chemical binding]; other site 158878006883 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 158878006884 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 158878006885 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 158878006886 Predicted permeases [General function prediction only]; Region: COG0679 158878006887 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 158878006888 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 158878006889 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 158878006890 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 158878006891 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 158878006892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878006893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158878006894 putative substrate translocation pore; other site 158878006895 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 158878006896 Transcriptional regulators [Transcription]; Region: MarR; COG1846 158878006897 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 158878006898 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158878006899 FeS/SAM binding site; other site 158878006900 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 158878006901 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 158878006902 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 158878006903 GTP binding site; other site 158878006904 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 158878006905 MoaE interaction surface [polypeptide binding]; other site 158878006906 MoeB interaction surface [polypeptide binding]; other site 158878006907 thiocarboxylated glycine; other site 158878006908 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 158878006909 MoaE homodimer interface [polypeptide binding]; other site 158878006910 MoaD interaction [polypeptide binding]; other site 158878006911 active site residues [active] 158878006912 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 158878006913 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 158878006914 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 158878006915 dimer interface [polypeptide binding]; other site 158878006916 putative functional site; other site 158878006917 putative MPT binding site; other site 158878006918 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 158878006919 trimer interface [polypeptide binding]; other site 158878006920 dimer interface [polypeptide binding]; other site 158878006921 putative active site [active] 158878006922 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 158878006923 MPT binding site; other site 158878006924 trimer interface [polypeptide binding]; other site 158878006925 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 158878006926 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 158878006927 ATP binding site [chemical binding]; other site 158878006928 substrate interface [chemical binding]; other site 158878006929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158878006930 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 158878006931 Walker A/P-loop; other site 158878006932 ATP binding site [chemical binding]; other site 158878006933 Q-loop/lid; other site 158878006934 ABC transporter signature motif; other site 158878006935 Walker B; other site 158878006936 D-loop; other site 158878006937 H-loop/switch region; other site 158878006938 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 158878006939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878006940 dimer interface [polypeptide binding]; other site 158878006941 conserved gate region; other site 158878006942 putative PBP binding loops; other site 158878006943 ABC-ATPase subunit interface; other site 158878006944 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 158878006945 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158878006946 substrate binding pocket [chemical binding]; other site 158878006947 membrane-bound complex binding site; other site 158878006948 hinge residues; other site 158878006949 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 158878006950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878006951 Coenzyme A binding pocket [chemical binding]; other site 158878006952 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 158878006953 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 158878006954 active site 158878006955 dimerization interface [polypeptide binding]; other site 158878006956 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 158878006957 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 158878006958 intersubunit interface [polypeptide binding]; other site 158878006959 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 158878006960 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 158878006961 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 158878006962 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 158878006963 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 158878006964 alpha-gamma subunit interface [polypeptide binding]; other site 158878006965 beta-gamma subunit interface [polypeptide binding]; other site 158878006966 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 158878006967 gamma-beta subunit interface [polypeptide binding]; other site 158878006968 alpha-beta subunit interface [polypeptide binding]; other site 158878006969 urease subunit alpha; Reviewed; Region: ureC; PRK13207 158878006970 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 158878006971 subunit interactions [polypeptide binding]; other site 158878006972 active site 158878006973 flap region; other site 158878006974 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 158878006975 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 158878006976 dimer interface [polypeptide binding]; other site 158878006977 catalytic residues [active] 158878006978 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 158878006979 UreF; Region: UreF; pfam01730 158878006980 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 158878006981 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 158878006982 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 158878006983 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 158878006984 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 158878006985 Transcriptional regulators [Transcription]; Region: MarR; COG1846 158878006986 Helix-turn-helix domain; Region: HTH_18; pfam12833 158878006987 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158878006988 Surface antigen [General function prediction only]; Region: COG3942 158878006989 CHAP domain; Region: CHAP; pfam05257 158878006990 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 158878006991 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 158878006992 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 158878006993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 158878006994 Surface antigen [General function prediction only]; Region: COG3942 158878006995 CHAP domain; Region: CHAP; pfam05257 158878006996 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 158878006997 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 158878006998 putative ligand binding site [chemical binding]; other site 158878006999 putative NAD binding site [chemical binding]; other site 158878007000 catalytic site [active] 158878007001 hypothetical protein; Provisional; Region: PRK06753 158878007002 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 158878007003 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 158878007004 Lysozyme subfamily 2; Region: LYZ2; smart00047 158878007005 Uncharacterized conserved protein [Function unknown]; Region: COG2427 158878007006 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 158878007007 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 158878007008 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 158878007009 4Fe-4S binding domain; Region: Fer4; pfam00037 158878007010 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 158878007011 [4Fe-4S] binding site [ion binding]; other site 158878007012 molybdopterin cofactor binding site; other site 158878007013 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 158878007014 molybdopterin cofactor binding site; other site 158878007015 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 158878007016 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 158878007017 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 158878007018 active site 158878007019 Predicted transcriptional regulator [Transcription]; Region: COG2378 158878007020 HTH domain; Region: HTH_11; pfam08279 158878007021 CAAX protease self-immunity; Region: Abi; pfam02517 158878007022 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158878007023 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 158878007024 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 158878007025 putative active site [active] 158878007026 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 158878007027 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 158878007028 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878007029 active site 158878007030 motif I; other site 158878007031 motif II; other site 158878007032 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 158878007033 Sodium Bile acid symporter family; Region: SBF; pfam01758 158878007034 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 158878007035 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 158878007036 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 158878007037 active site turn [active] 158878007038 phosphorylation site [posttranslational modification] 158878007039 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158878007040 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 158878007041 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 158878007042 putative active site [active] 158878007043 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 158878007044 putative hydrophobic ligand binding site [chemical binding]; other site 158878007045 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 158878007046 oxidoreductase; Provisional; Region: PRK07985 158878007047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158878007048 NAD(P) binding site [chemical binding]; other site 158878007049 active site 158878007050 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 158878007051 amidohydrolase; Region: amidohydrolases; TIGR01891 158878007052 metal binding site [ion binding]; metal-binding site 158878007053 dimer interface [polypeptide binding]; other site 158878007054 imidazolonepropionase; Validated; Region: PRK09356 158878007055 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 158878007056 active site 158878007057 urocanate hydratase; Provisional; Region: PRK05414 158878007058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 158878007059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 158878007060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 158878007061 dimerization interface [polypeptide binding]; other site 158878007062 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 158878007063 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 158878007064 putative active site [active] 158878007065 putative Mg binding site [ion binding]; other site 158878007066 formimidoylglutamase; Provisional; Region: PRK13775 158878007067 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 158878007068 putative active site [active] 158878007069 putative metal binding site [ion binding]; other site 158878007070 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 158878007071 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 158878007072 tetramer (dimer of dimers) interface [polypeptide binding]; other site 158878007073 active site 158878007074 dimer interface [polypeptide binding]; other site 158878007075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 158878007076 MOSC domain; Region: MOSC; pfam03473 158878007077 3-alpha domain; Region: 3-alpha; pfam03475 158878007078 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 158878007079 active site 158878007080 catalytic residues [active] 158878007081 Uncharacterized conserved protein [Function unknown]; Region: COG1742 158878007082 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 158878007083 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 158878007084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158878007085 Walker A/P-loop; other site 158878007086 ATP binding site [chemical binding]; other site 158878007087 Q-loop/lid; other site 158878007088 ABC transporter signature motif; other site 158878007089 Walker B; other site 158878007090 D-loop; other site 158878007091 H-loop/switch region; other site 158878007092 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 158878007093 Predicted membrane protein [Function unknown]; Region: COG3152 158878007094 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 158878007095 active site 158878007096 DNA binding site [nucleotide binding] 158878007097 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 158878007098 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 158878007099 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 158878007100 homotetramer interface [polypeptide binding]; other site 158878007101 FMN binding site [chemical binding]; other site 158878007102 homodimer contacts [polypeptide binding]; other site 158878007103 putative active site [active] 158878007104 putative substrate binding site [chemical binding]; other site 158878007105 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 158878007106 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 158878007107 oligomer interface [polypeptide binding]; other site 158878007108 metal binding site [ion binding]; metal-binding site 158878007109 metal binding site [ion binding]; metal-binding site 158878007110 putative Cl binding site [ion binding]; other site 158878007111 aspartate ring; other site 158878007112 basic sphincter; other site 158878007113 hydrophobic gate; other site 158878007114 periplasmic entrance; other site 158878007115 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 158878007116 active site 158878007117 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 158878007118 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 158878007119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878007120 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 158878007121 putative substrate translocation pore; other site 158878007122 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 158878007123 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 158878007124 HlyD family secretion protein; Region: HlyD_3; pfam13437 158878007125 lipoyl-biotinyl attachment site [posttranslational modification]; other site 158878007126 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 158878007127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878007128 putative substrate translocation pore; other site 158878007129 Predicted membrane protein [Function unknown]; Region: COG4640 158878007130 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 158878007131 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 158878007132 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158878007133 putative Zn2+ binding site [ion binding]; other site 158878007134 putative DNA binding site [nucleotide binding]; other site 158878007135 Uncharacterized conserved protein [Function unknown]; Region: COG1434 158878007136 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 158878007137 putative active site [active] 158878007138 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158878007139 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158878007140 Walker A/P-loop; other site 158878007141 ATP binding site [chemical binding]; other site 158878007142 Q-loop/lid; other site 158878007143 ABC transporter signature motif; other site 158878007144 Walker B; other site 158878007145 D-loop; other site 158878007146 H-loop/switch region; other site 158878007147 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 158878007148 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 158878007149 FtsX-like permease family; Region: FtsX; pfam02687 158878007150 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158878007151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878007152 active site 158878007153 phosphorylation site [posttranslational modification] 158878007154 intermolecular recognition site; other site 158878007155 dimerization interface [polypeptide binding]; other site 158878007156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158878007157 DNA binding site [nucleotide binding] 158878007158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158878007159 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158878007160 dimerization interface [polypeptide binding]; other site 158878007161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158878007162 dimer interface [polypeptide binding]; other site 158878007163 phosphorylation site [posttranslational modification] 158878007164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878007165 ATP binding site [chemical binding]; other site 158878007166 Mg2+ binding site [ion binding]; other site 158878007167 G-X-G motif; other site 158878007168 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 158878007169 LytTr DNA-binding domain; Region: LytTR; smart00850 158878007170 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 158878007171 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 158878007172 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 158878007173 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 158878007174 L-lactate permease; Region: Lactate_perm; cl00701 158878007175 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 158878007176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878007177 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158878007178 Coenzyme A binding pocket [chemical binding]; other site 158878007179 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 158878007180 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 158878007181 NAD(P) binding site [chemical binding]; other site 158878007182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878007183 Coenzyme A binding pocket [chemical binding]; other site 158878007184 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 158878007185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158878007186 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158878007187 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 158878007188 Predicted membrane protein [Function unknown]; Region: COG1511 158878007189 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 158878007190 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 158878007191 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 158878007192 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 158878007193 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 158878007194 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 158878007195 Cl binding site [ion binding]; other site 158878007196 oligomer interface [polypeptide binding]; other site 158878007197 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 158878007198 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 158878007199 active site turn [active] 158878007200 phosphorylation site [posttranslational modification] 158878007201 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 158878007202 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 158878007203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 158878007204 Transposase; Region: DDE_Tnp_ISL3; pfam01610 158878007205 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158878007206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158878007207 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 158878007208 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 158878007209 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 158878007210 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 158878007211 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 158878007212 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 158878007213 MarR family; Region: MarR_2; pfam12802 158878007214 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 158878007215 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 158878007216 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 158878007217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878007218 putative substrate translocation pore; other site 158878007219 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 158878007220 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 158878007221 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 158878007222 DNA binding residues [nucleotide binding] 158878007223 dimer interface [polypeptide binding]; other site 158878007224 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 158878007225 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158878007226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878007227 active site 158878007228 phosphorylation site [posttranslational modification] 158878007229 intermolecular recognition site; other site 158878007230 dimerization interface [polypeptide binding]; other site 158878007231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158878007232 DNA binding residues [nucleotide binding] 158878007233 dimerization interface [polypeptide binding]; other site 158878007234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 158878007235 Histidine kinase; Region: HisKA_3; pfam07730 158878007236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878007237 ATP binding site [chemical binding]; other site 158878007238 Mg2+ binding site [ion binding]; other site 158878007239 G-X-G motif; other site 158878007240 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 158878007241 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 158878007242 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 158878007243 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 158878007244 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 158878007245 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 158878007246 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 158878007247 [4Fe-4S] binding site [ion binding]; other site 158878007248 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 158878007249 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 158878007250 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 158878007251 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 158878007252 molybdopterin cofactor binding site; other site 158878007253 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 158878007254 active site 158878007255 SAM binding site [chemical binding]; other site 158878007256 homodimer interface [polypeptide binding]; other site 158878007257 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 158878007258 [2Fe-2S] cluster binding site [ion binding]; other site 158878007259 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 158878007260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158878007261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158878007262 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 158878007263 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 158878007264 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 158878007265 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 158878007266 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 158878007267 putative active site [active] 158878007268 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 158878007269 active site 158878007270 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158878007271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878007272 Coenzyme A binding pocket [chemical binding]; other site 158878007273 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 158878007274 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 158878007275 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 158878007276 putative hydrophobic ligand binding site [chemical binding]; other site 158878007277 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 158878007278 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 158878007279 intersubunit interface [polypeptide binding]; other site 158878007280 YodA lipocalin-like domain; Region: YodA; pfam09223 158878007281 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 158878007282 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 158878007283 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 158878007284 Thioredoxin; Region: Thioredoxin_4; cl17273 158878007285 FemAB family; Region: FemAB; pfam02388 158878007286 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 158878007287 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 158878007288 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 158878007289 Walker A/P-loop; other site 158878007290 ATP binding site [chemical binding]; other site 158878007291 Q-loop/lid; other site 158878007292 ABC transporter signature motif; other site 158878007293 Walker B; other site 158878007294 D-loop; other site 158878007295 H-loop/switch region; other site 158878007296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 158878007297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878007298 putative PBP binding loops; other site 158878007299 dimer interface [polypeptide binding]; other site 158878007300 ABC-ATPase subunit interface; other site 158878007301 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158878007302 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158878007303 substrate binding pocket [chemical binding]; other site 158878007304 membrane-bound complex binding site; other site 158878007305 hinge residues; other site 158878007306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878007307 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158878007308 putative substrate translocation pore; other site 158878007309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878007310 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 158878007311 catalytic core [active] 158878007312 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 158878007313 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 158878007314 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 158878007315 B domain; Region: B; pfam02216 158878007316 B domain; Region: B; pfam02216 158878007317 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 158878007318 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 158878007319 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 158878007320 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 158878007321 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 158878007322 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 158878007323 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 158878007324 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158878007325 catalytic residue [active] 158878007326 biotin synthase; Validated; Region: PRK06256 158878007327 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158878007328 FeS/SAM binding site; other site 158878007329 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 158878007330 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 158878007331 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 158878007332 inhibitor-cofactor binding pocket; inhibition site 158878007333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878007334 catalytic residue [active] 158878007335 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 158878007336 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 158878007337 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 158878007338 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 158878007339 Walker A/P-loop; other site 158878007340 ATP binding site [chemical binding]; other site 158878007341 Q-loop/lid; other site 158878007342 ABC transporter signature motif; other site 158878007343 Walker B; other site 158878007344 D-loop; other site 158878007345 H-loop/switch region; other site 158878007346 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 158878007347 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 158878007348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158878007349 Walker A/P-loop; other site 158878007350 ATP binding site [chemical binding]; other site 158878007351 Q-loop/lid; other site 158878007352 ABC transporter signature motif; other site 158878007353 Walker B; other site 158878007354 D-loop; other site 158878007355 H-loop/switch region; other site 158878007356 Predicted membrane protein [Function unknown]; Region: COG2246 158878007357 GtrA-like protein; Region: GtrA; pfam04138 158878007358 glycerate kinase; Region: TIGR00045 158878007359 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 158878007360 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 158878007361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878007362 putative substrate translocation pore; other site 158878007363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 158878007364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 158878007365 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 158878007366 putative phosphoesterase; Region: acc_ester; TIGR03729 158878007367 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 158878007368 Spore germination protein; Region: Spore_permease; cl17796 158878007369 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 158878007370 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 158878007371 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 158878007372 Beta-lactamase; Region: Beta-lactamase; pfam00144 158878007373 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 158878007374 extended (e) SDRs; Region: SDR_e; cd08946 158878007375 NAD(P) binding site [chemical binding]; other site 158878007376 active site 158878007377 substrate binding site [chemical binding]; other site 158878007378 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 158878007379 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 158878007380 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 158878007381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878007382 putative substrate translocation pore; other site 158878007383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878007384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878007385 dimer interface [polypeptide binding]; other site 158878007386 conserved gate region; other site 158878007387 ABC-ATPase subunit interface; other site 158878007388 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 158878007389 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 158878007390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878007391 dimer interface [polypeptide binding]; other site 158878007392 conserved gate region; other site 158878007393 putative PBP binding loops; other site 158878007394 ABC-ATPase subunit interface; other site 158878007395 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 158878007396 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 158878007397 Walker A/P-loop; other site 158878007398 ATP binding site [chemical binding]; other site 158878007399 Q-loop/lid; other site 158878007400 ABC transporter signature motif; other site 158878007401 Walker B; other site 158878007402 D-loop; other site 158878007403 H-loop/switch region; other site 158878007404 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 158878007405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 158878007406 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 158878007407 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 158878007408 amino acid transporter; Region: 2A0306; TIGR00909 158878007409 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 158878007410 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 158878007411 substrate binding pocket [chemical binding]; other site 158878007412 catalytic triad [active] 158878007413 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 158878007414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878007415 putative substrate translocation pore; other site 158878007416 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 158878007417 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 158878007418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158878007419 Walker A/P-loop; other site 158878007420 ATP binding site [chemical binding]; other site 158878007421 Q-loop/lid; other site 158878007422 ABC transporter signature motif; other site 158878007423 Walker B; other site 158878007424 D-loop; other site 158878007425 H-loop/switch region; other site 158878007426 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 158878007427 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 158878007428 oligomer interface [polypeptide binding]; other site 158878007429 active site 158878007430 metal binding site [ion binding]; metal-binding site 158878007431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 158878007432 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 158878007433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 158878007434 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 158878007435 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 158878007436 active site 158878007437 FMN binding site [chemical binding]; other site 158878007438 substrate binding site [chemical binding]; other site 158878007439 3Fe-4S cluster binding site [ion binding]; other site 158878007440 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 158878007441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878007442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158878007443 putative substrate translocation pore; other site 158878007444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 158878007445 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158878007446 Walker A/P-loop; other site 158878007447 ATP binding site [chemical binding]; other site 158878007448 Q-loop/lid; other site 158878007449 ABC transporter signature motif; other site 158878007450 Walker B; other site 158878007451 D-loop; other site 158878007452 H-loop/switch region; other site 158878007453 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158878007454 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 158878007455 Walker A/P-loop; other site 158878007456 ATP binding site [chemical binding]; other site 158878007457 Q-loop/lid; other site 158878007458 ABC transporter signature motif; other site 158878007459 Walker B; other site 158878007460 D-loop; other site 158878007461 H-loop/switch region; other site 158878007462 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 158878007463 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 158878007464 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 158878007465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878007466 dimer interface [polypeptide binding]; other site 158878007467 conserved gate region; other site 158878007468 ABC-ATPase subunit interface; other site 158878007469 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 158878007470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158878007471 dimer interface [polypeptide binding]; other site 158878007472 conserved gate region; other site 158878007473 putative PBP binding loops; other site 158878007474 ABC-ATPase subunit interface; other site 158878007475 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 158878007476 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 158878007477 substrate binding site [chemical binding]; other site 158878007478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 158878007479 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 158878007480 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 158878007481 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 158878007482 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 158878007483 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 158878007484 short chain dehydrogenase; Validated; Region: PRK08589 158878007485 classical (c) SDRs; Region: SDR_c; cd05233 158878007486 NAD(P) binding site [chemical binding]; other site 158878007487 active site 158878007488 AbgT putative transporter family; Region: ABG_transport; pfam03806 158878007489 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 158878007490 Uncharacterized conserved protein [Function unknown]; Region: COG2128 158878007491 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 158878007492 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 158878007493 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 158878007494 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 158878007495 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 158878007496 classical (c) SDRs; Region: SDR_c; cd05233 158878007497 NAD(P) binding site [chemical binding]; other site 158878007498 active site 158878007499 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 158878007500 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878007501 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878007502 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878007503 Protein of unknown function, DUF576; Region: DUF576; pfam04507 158878007504 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158878007505 nucleotide binding region [chemical binding]; other site 158878007506 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 158878007507 ATP-binding site [chemical binding]; other site 158878007508 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 158878007509 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 158878007510 PLD-like domain; Region: PLDc_2; pfam13091 158878007511 putative homodimer interface [polypeptide binding]; other site 158878007512 putative active site [active] 158878007513 catalytic site [active] 158878007514 DEAD-like helicases superfamily; Region: DEXDc; smart00487 158878007515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158878007516 ATP binding site [chemical binding]; other site 158878007517 putative Mg++ binding site [ion binding]; other site 158878007518 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 158878007519 active site 158878007520 8-oxo-dGMP binding site [chemical binding]; other site 158878007521 nudix motif; other site 158878007522 metal binding site [ion binding]; metal-binding site 158878007523 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 158878007524 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 158878007525 active site 158878007526 substrate binding site [chemical binding]; other site 158878007527 metal binding site [ion binding]; metal-binding site 158878007528 H+ Antiporter protein; Region: 2A0121; TIGR00900 158878007529 G5 domain; Region: G5; pfam07501 158878007530 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 158878007531 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 158878007532 legume lectins; Region: lectin_L-type; cl14058 158878007533 homotetramer interaction site [polypeptide binding]; other site 158878007534 carbohydrate binding site [chemical binding]; other site 158878007535 metal binding site [ion binding]; metal-binding site 158878007536 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 158878007537 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 158878007538 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 158878007539 Transcriptional regulators [Transcription]; Region: MarR; COG1846 158878007540 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 158878007541 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 158878007542 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 158878007543 active site 158878007544 tetramer interface; other site 158878007545 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 158878007546 Transposase; Region: DDE_Tnp_ISL3; pfam01610 158878007547 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 158878007548 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 158878007549 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 158878007550 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 158878007551 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 158878007552 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 158878007553 GntP family permease; Region: GntP_permease; pfam02447 158878007554 fructuronate transporter; Provisional; Region: PRK10034; cl15264 158878007555 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 158878007556 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 158878007557 N- and C-terminal domain interface [polypeptide binding]; other site 158878007558 active site 158878007559 catalytic site [active] 158878007560 metal binding site [ion binding]; metal-binding site 158878007561 carbohydrate binding site [chemical binding]; other site 158878007562 ATP binding site [chemical binding]; other site 158878007563 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158878007564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158878007565 DNA-binding site [nucleotide binding]; DNA binding site 158878007566 FCD domain; Region: FCD; pfam07729 158878007567 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 158878007568 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 158878007569 DNA binding residues [nucleotide binding] 158878007570 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 158878007571 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 158878007572 synthetase active site [active] 158878007573 NTP binding site [chemical binding]; other site 158878007574 metal binding site [ion binding]; metal-binding site 158878007575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 158878007576 Predicted membrane protein [Function unknown]; Region: COG1289 158878007577 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 158878007578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878007579 D-galactonate transporter; Region: 2A0114; TIGR00893 158878007580 putative substrate translocation pore; other site 158878007581 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 158878007582 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 158878007583 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 158878007584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158878007585 Walker A/P-loop; other site 158878007586 ATP binding site [chemical binding]; other site 158878007587 Q-loop/lid; other site 158878007588 ABC transporter signature motif; other site 158878007589 Walker B; other site 158878007590 D-loop; other site 158878007591 H-loop/switch region; other site 158878007592 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 158878007593 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 158878007594 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 158878007595 Uncharacterized membrane protein [Function unknown]; Region: COG3949 158878007596 Predicted esterase [General function prediction only]; Region: COG0400 158878007597 putative hydrolase; Provisional; Region: PRK11460 158878007598 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 158878007599 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158878007600 Zn binding site [ion binding]; other site 158878007601 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 158878007602 Zn binding site [ion binding]; other site 158878007603 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 158878007604 MarR family; Region: MarR; pfam01047 158878007605 Predicted acetyltransferase [General function prediction only]; Region: COG2388 158878007606 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 158878007607 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 158878007608 putative metal binding site [ion binding]; other site 158878007609 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 158878007610 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 158878007611 dimer interface [polypeptide binding]; other site 158878007612 FMN binding site [chemical binding]; other site 158878007613 D-lactate dehydrogenase; Provisional; Region: PRK12480 158878007614 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 158878007615 homodimer interface [polypeptide binding]; other site 158878007616 ligand binding site [chemical binding]; other site 158878007617 NAD binding site [chemical binding]; other site 158878007618 catalytic site [active] 158878007619 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 158878007620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158878007621 active site 158878007622 motif I; other site 158878007623 motif II; other site 158878007624 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158878007625 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 158878007626 Walker A/P-loop; other site 158878007627 ATP binding site [chemical binding]; other site 158878007628 Q-loop/lid; other site 158878007629 ABC transporter signature motif; other site 158878007630 Walker B; other site 158878007631 D-loop; other site 158878007632 H-loop/switch region; other site 158878007633 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 158878007634 active site 158878007635 catalytic site [active] 158878007636 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 158878007637 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878007638 Coenzyme A binding pocket [chemical binding]; other site 158878007639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158878007640 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 158878007641 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 158878007642 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 158878007643 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 158878007644 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 158878007645 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 158878007646 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 158878007647 EamA-like transporter family; Region: EamA; pfam00892 158878007648 EamA-like transporter family; Region: EamA; pfam00892 158878007649 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 158878007650 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 158878007651 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 158878007652 catalytic residues [active] 158878007653 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 158878007654 active site 158878007655 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 158878007656 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 158878007657 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 158878007658 active site turn [active] 158878007659 phosphorylation site [posttranslational modification] 158878007660 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 158878007661 HPr interaction site; other site 158878007662 glycerol kinase (GK) interaction site [polypeptide binding]; other site 158878007663 active site 158878007664 phosphorylation site [posttranslational modification] 158878007665 pyruvate oxidase; Provisional; Region: PRK08611 158878007666 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 158878007667 PYR/PP interface [polypeptide binding]; other site 158878007668 tetramer interface [polypeptide binding]; other site 158878007669 dimer interface [polypeptide binding]; other site 158878007670 TPP binding site [chemical binding]; other site 158878007671 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 158878007672 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 158878007673 TPP-binding site [chemical binding]; other site 158878007674 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 158878007675 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 158878007676 Transcriptional regulator [Transcription]; Region: LysR; COG0583 158878007677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 158878007678 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 158878007679 putative dimerization interface [polypeptide binding]; other site 158878007680 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 158878007681 Surface antigen [General function prediction only]; Region: COG3942 158878007682 CHAP domain; Region: CHAP; pfam05257 158878007683 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 158878007684 homodimer interface [polypeptide binding]; other site 158878007685 catalytic residues [active] 158878007686 NAD binding site [chemical binding]; other site 158878007687 substrate binding pocket [chemical binding]; other site 158878007688 flexible flap; other site 158878007689 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 158878007690 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 158878007691 dimer interface [polypeptide binding]; other site 158878007692 active site 158878007693 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 158878007694 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 158878007695 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 158878007696 DNA binding site [nucleotide binding] 158878007697 active site 158878007698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878007699 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 158878007700 Walker A motif; other site 158878007701 ATP binding site [chemical binding]; other site 158878007702 Walker B motif; other site 158878007703 arginine finger; other site 158878007704 UvrB/uvrC motif; Region: UVR; pfam02151 158878007705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158878007706 Walker A motif; other site 158878007707 ATP binding site [chemical binding]; other site 158878007708 Walker B motif; other site 158878007709 arginine finger; other site 158878007710 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 158878007711 Virus attachment protein p12 family; Region: P12; pfam12669 158878007712 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 158878007713 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 158878007714 G1 box; other site 158878007715 GTP/Mg2+ binding site [chemical binding]; other site 158878007716 Switch I region; other site 158878007717 G2 box; other site 158878007718 G3 box; other site 158878007719 Switch II region; other site 158878007720 G4 box; other site 158878007721 G5 box; other site 158878007722 Nucleoside recognition; Region: Gate; pfam07670 158878007723 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 158878007724 Nucleoside recognition; Region: Gate; pfam07670 158878007725 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 158878007726 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 158878007727 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 158878007728 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158878007729 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 158878007730 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 158878007731 Glutamate binding site [chemical binding]; other site 158878007732 homodimer interface [polypeptide binding]; other site 158878007733 NAD binding site [chemical binding]; other site 158878007734 catalytic residues [active] 158878007735 maltose O-acetyltransferase; Provisional; Region: PRK10092 158878007736 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 158878007737 active site 158878007738 substrate binding site [chemical binding]; other site 158878007739 trimer interface [polypeptide binding]; other site 158878007740 CoA binding site [chemical binding]; other site 158878007741 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 158878007742 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158878007743 metal-binding site [ion binding] 158878007744 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 158878007745 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158878007746 metal-binding site [ion binding] 158878007747 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 158878007748 Soluble P-type ATPase [General function prediction only]; Region: COG4087 158878007749 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 158878007750 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158878007751 metal-binding site [ion binding] 158878007752 D-lactate dehydrogenase; Validated; Region: PRK08605 158878007753 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 158878007754 homodimer interface [polypeptide binding]; other site 158878007755 ligand binding site [chemical binding]; other site 158878007756 NAD binding site [chemical binding]; other site 158878007757 catalytic site [active] 158878007758 transaminase; Reviewed; Region: PRK08068 158878007759 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158878007760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878007761 homodimer interface [polypeptide binding]; other site 158878007762 catalytic residue [active] 158878007763 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 158878007764 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158878007765 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 158878007766 active site lid residues [active] 158878007767 substrate binding pocket [chemical binding]; other site 158878007768 catalytic residues [active] 158878007769 substrate-Mg2+ binding site; other site 158878007770 aspartate-rich region 1; other site 158878007771 aspartate-rich region 2; other site 158878007772 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 158878007773 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 158878007774 active site 158878007775 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 158878007776 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158878007777 Surface antigen [General function prediction only]; Region: COG3942 158878007778 CHAP domain; Region: CHAP; pfam05257 158878007779 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 158878007780 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 158878007781 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 158878007782 catalytic triad [active] 158878007783 catalytic triad [active] 158878007784 oxyanion hole [active] 158878007785 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878007786 Coenzyme A binding pocket [chemical binding]; other site 158878007787 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 158878007788 N-acetyl-D-glucosamine binding site [chemical binding]; other site 158878007789 catalytic residue [active] 158878007790 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 158878007791 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 158878007792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158878007793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158878007794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 158878007795 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 158878007796 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 158878007797 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158878007798 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 158878007799 NmrA-like family; Region: NmrA; pfam05368 158878007800 NADP binding site [chemical binding]; other site 158878007801 active site 158878007802 regulatory binding site [polypeptide binding]; other site 158878007803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 158878007804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158878007805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158878007806 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 158878007807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158878007808 NAD(P) binding site [chemical binding]; other site 158878007809 active site 158878007810 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 158878007811 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 158878007812 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 158878007813 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 158878007814 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 158878007815 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 158878007816 Nucleoside recognition; Region: Gate; pfam07670 158878007817 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 158878007818 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 158878007819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 158878007820 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 158878007821 Phosphotransferase enzyme family; Region: APH; pfam01636 158878007822 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 158878007823 active site 158878007824 ATP binding site [chemical binding]; other site 158878007825 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 158878007826 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 158878007827 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 158878007828 quinone interaction residues [chemical binding]; other site 158878007829 active site 158878007830 catalytic residues [active] 158878007831 FMN binding site [chemical binding]; other site 158878007832 substrate binding site [chemical binding]; other site 158878007833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 158878007834 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 158878007835 dimer interface [polypeptide binding]; other site 158878007836 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158878007837 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158878007838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158878007839 Predicted acyl esterases [General function prediction only]; Region: COG2936 158878007840 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 158878007841 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 158878007842 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 158878007843 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 158878007844 tetramerization interface [polypeptide binding]; other site 158878007845 active site 158878007846 pantoate--beta-alanine ligase; Region: panC; TIGR00018 158878007847 Pantoate-beta-alanine ligase; Region: PanC; cd00560 158878007848 active site 158878007849 ATP-binding site [chemical binding]; other site 158878007850 pantoate-binding site; other site 158878007851 HXXH motif; other site 158878007852 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 158878007853 active site 158878007854 oligomerization interface [polypeptide binding]; other site 158878007855 metal binding site [ion binding]; metal-binding site 158878007856 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 158878007857 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 158878007858 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 158878007859 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 158878007860 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 158878007861 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 158878007862 tetramer (dimer of dimers) interface [polypeptide binding]; other site 158878007863 NAD binding site [chemical binding]; other site 158878007864 dimer interface [polypeptide binding]; other site 158878007865 substrate binding site [chemical binding]; other site 158878007866 amino acid transporter; Region: 2A0306; TIGR00909 158878007867 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 158878007868 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 158878007869 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 158878007870 inhibitor-cofactor binding pocket; inhibition site 158878007871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878007872 catalytic residue [active] 158878007873 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 158878007874 catalytic residue [active] 158878007875 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 158878007876 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 158878007877 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 158878007878 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 158878007879 acyl-activating enzyme (AAE) consensus motif; other site 158878007880 AMP binding site [chemical binding]; other site 158878007881 active site 158878007882 CoA binding site [chemical binding]; other site 158878007883 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 158878007884 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 158878007885 choline dehydrogenase; Validated; Region: PRK02106 158878007886 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 158878007887 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 158878007888 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 158878007889 tetramerization interface [polypeptide binding]; other site 158878007890 NAD(P) binding site [chemical binding]; other site 158878007891 catalytic residues [active] 158878007892 Predicted transcriptional regulators [Transcription]; Region: COG1510 158878007893 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 158878007894 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 158878007895 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158878007896 FeS/SAM binding site; other site 158878007897 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 158878007898 Class III ribonucleotide reductase; Region: RNR_III; cd01675 158878007899 effector binding site; other site 158878007900 active site 158878007901 Zn binding site [ion binding]; other site 158878007902 glycine loop; other site 158878007903 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 158878007904 Citrate transporter; Region: CitMHS; pfam03600 158878007905 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 158878007906 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 158878007907 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 158878007908 Flavodoxin; Region: Flavodoxin_1; pfam00258 158878007909 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 158878007910 FAD binding pocket [chemical binding]; other site 158878007911 FAD binding motif [chemical binding]; other site 158878007912 catalytic residues [active] 158878007913 NAD binding pocket [chemical binding]; other site 158878007914 phosphate binding motif [ion binding]; other site 158878007915 beta-alpha-beta structure motif; other site 158878007916 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 158878007917 catalytic residues [active] 158878007918 dimer interface [polypeptide binding]; other site 158878007919 FtsX-like permease family; Region: FtsX; pfam02687 158878007920 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158878007921 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158878007922 Walker A/P-loop; other site 158878007923 ATP binding site [chemical binding]; other site 158878007924 Q-loop/lid; other site 158878007925 ABC transporter signature motif; other site 158878007926 Walker B; other site 158878007927 D-loop; other site 158878007928 H-loop/switch region; other site 158878007929 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158878007930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158878007931 ATP binding site [chemical binding]; other site 158878007932 Mg2+ binding site [ion binding]; other site 158878007933 G-X-G motif; other site 158878007934 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158878007935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158878007936 active site 158878007937 phosphorylation site [posttranslational modification] 158878007938 intermolecular recognition site; other site 158878007939 dimerization interface [polypeptide binding]; other site 158878007940 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158878007941 DNA binding site [nucleotide binding] 158878007942 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 158878007943 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 158878007944 dimer interface [polypeptide binding]; other site 158878007945 active site 158878007946 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 158878007947 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 158878007948 MarR family; Region: MarR_2; pfam12802 158878007949 Predicted esterase [General function prediction only]; Region: COG0627 158878007950 S-formylglutathione hydrolase; Region: PLN02442 158878007951 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 158878007952 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 158878007953 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158878007954 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158878007955 ligand binding site [chemical binding]; other site 158878007956 flexible hinge region; other site 158878007957 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 158878007958 carbamate kinase; Reviewed; Region: PRK12686 158878007959 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 158878007960 putative substrate binding site [chemical binding]; other site 158878007961 nucleotide binding site [chemical binding]; other site 158878007962 nucleotide binding site [chemical binding]; other site 158878007963 homodimer interface [polypeptide binding]; other site 158878007964 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 158878007965 ornithine carbamoyltransferase; Validated; Region: PRK02102 158878007966 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 158878007967 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 158878007968 arginine deiminase; Provisional; Region: PRK01388 158878007969 Arginine repressor [Transcription]; Region: ArgR; COG1438 158878007970 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 158878007971 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 158878007972 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 158878007973 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 158878007974 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 158878007975 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 158878007976 active site 158878007977 Zn binding site [ion binding]; other site 158878007978 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 158878007979 HTH domain; Region: HTH_11; pfam08279 158878007980 PRD domain; Region: PRD; pfam00874 158878007981 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 158878007982 active site 158878007983 P-loop; other site 158878007984 phosphorylation site [posttranslational modification] 158878007985 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158878007986 active site 158878007987 phosphorylation site [posttranslational modification] 158878007988 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 158878007989 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 158878007990 active site 158878007991 P-loop; other site 158878007992 phosphorylation site [posttranslational modification] 158878007993 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 158878007994 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158878007995 active site 158878007996 phosphorylation site [posttranslational modification] 158878007997 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 158878007998 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 158878007999 Predicted membrane protein [Function unknown]; Region: COG1511 158878008000 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 158878008001 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 158878008002 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 158878008003 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 158878008004 CHAP domain; Region: CHAP; pfam05257 158878008005 Isochorismatase family; Region: Isochorismatase; pfam00857 158878008006 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 158878008007 catalytic triad [active] 158878008008 conserved cis-peptide bond; other site 158878008009 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 158878008010 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 158878008011 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 158878008012 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 158878008013 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 158878008014 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 158878008015 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 158878008016 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 158878008017 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 158878008018 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 158878008019 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 158878008020 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 158878008021 SecY translocase; Region: SecY; pfam00344 158878008022 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 158878008023 legume lectins; Region: lectin_L-type; cd01951 158878008024 homotetramer interaction site [polypeptide binding]; other site 158878008025 carbohydrate binding site [chemical binding]; other site 158878008026 metal binding site [ion binding]; metal-binding site 158878008027 Putative Ig domain; Region: He_PIG; pfam05345 158878008028 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 158878008029 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 158878008030 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 158878008031 methionine sulfoxide reductase A; Provisional; Region: PRK05528 158878008032 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 158878008033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878008034 Coenzyme A binding pocket [chemical binding]; other site 158878008035 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 158878008036 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 158878008037 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 158878008038 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 158878008039 Chain length determinant protein; Region: Wzz; cl15801 158878008040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158878008041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158878008042 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 158878008043 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 158878008044 DXD motif; other site 158878008045 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 158878008046 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 158878008047 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 158878008048 Acyltransferase family; Region: Acyl_transf_3; pfam01757 158878008049 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 158878008050 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 158878008051 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 158878008052 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 158878008053 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 158878008054 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 158878008055 metal binding site [ion binding]; metal-binding site 158878008056 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 158878008057 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 158878008058 substrate binding site [chemical binding]; other site 158878008059 glutamase interaction surface [polypeptide binding]; other site 158878008060 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 158878008061 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 158878008062 catalytic residues [active] 158878008063 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 158878008064 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 158878008065 putative active site [active] 158878008066 oxyanion strand; other site 158878008067 catalytic triad [active] 158878008068 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 158878008069 putative active site pocket [active] 158878008070 4-fold oligomerization interface [polypeptide binding]; other site 158878008071 metal binding residues [ion binding]; metal-binding site 158878008072 3-fold/trimer interface [polypeptide binding]; other site 158878008073 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 158878008074 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158878008075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158878008076 homodimer interface [polypeptide binding]; other site 158878008077 catalytic residue [active] 158878008078 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 158878008079 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 158878008080 NAD binding site [chemical binding]; other site 158878008081 dimerization interface [polypeptide binding]; other site 158878008082 product binding site; other site 158878008083 substrate binding site [chemical binding]; other site 158878008084 zinc binding site [ion binding]; other site 158878008085 catalytic residues [active] 158878008086 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 158878008087 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 158878008088 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 158878008089 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 158878008090 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 158878008091 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 158878008092 putative active site [active] 158878008093 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 158878008094 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 158878008095 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158878008096 Walker A/P-loop; other site 158878008097 ATP binding site [chemical binding]; other site 158878008098 ABC transporter; Region: ABC_tran; pfam00005 158878008099 Q-loop/lid; other site 158878008100 ABC transporter signature motif; other site 158878008101 Walker B; other site 158878008102 D-loop; other site 158878008103 H-loop/switch region; other site 158878008104 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 158878008105 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 158878008106 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158878008107 Walker A/P-loop; other site 158878008108 ATP binding site [chemical binding]; other site 158878008109 Q-loop/lid; other site 158878008110 ABC transporter signature motif; other site 158878008111 Walker B; other site 158878008112 D-loop; other site 158878008113 H-loop/switch region; other site 158878008114 hypothetical protein; Provisional; Region: PRK13661 158878008115 Uncharacterized conserved protein [Function unknown]; Region: COG1912 158878008116 Uncharacterized conserved protein [Function unknown]; Region: COG2353 158878008117 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 158878008118 Strictosidine synthase; Region: Str_synth; pfam03088 158878008119 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 158878008120 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 158878008121 active site residue [active] 158878008122 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 158878008123 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 158878008124 putative substrate binding pocket [chemical binding]; other site 158878008125 AC domain interface; other site 158878008126 catalytic triad [active] 158878008127 AB domain interface; other site 158878008128 interchain disulfide; other site 158878008129 Predicted transcriptional regulators [Transcription]; Region: COG1695 158878008130 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 158878008131 DinB superfamily; Region: DinB_2; pfam12867 158878008132 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 158878008133 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 158878008134 transmembrane helices; other site 158878008135 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 158878008136 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 158878008137 Predicted permeases [General function prediction only]; Region: RarD; COG2962 158878008138 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 158878008139 hypothetical protein; Provisional; Region: PRK07758 158878008140 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 158878008141 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 158878008142 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 158878008143 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158878008144 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158878008145 Walker A/P-loop; other site 158878008146 ATP binding site [chemical binding]; other site 158878008147 Q-loop/lid; other site 158878008148 ABC transporter signature motif; other site 158878008149 Walker B; other site 158878008150 D-loop; other site 158878008151 H-loop/switch region; other site 158878008152 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 158878008153 FtsX-like permease family; Region: FtsX; pfam02687 158878008154 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 158878008155 DNA-binding site [nucleotide binding]; DNA binding site 158878008156 RNA-binding motif; other site 158878008157 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158878008158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878008159 non-specific DNA binding site [nucleotide binding]; other site 158878008160 salt bridge; other site 158878008161 sequence-specific DNA binding site [nucleotide binding]; other site 158878008162 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 158878008163 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 158878008164 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 158878008165 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 158878008166 ParB-like nuclease domain; Region: ParBc; pfam02195 158878008167 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 158878008168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158878008169 S-adenosylmethionine binding site [chemical binding]; other site 158878008170 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 158878008171 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 158878008172 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 158878008173 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 158878008174 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 158878008175 trmE is a tRNA modification GTPase; Region: trmE; cd04164 158878008176 G1 box; other site 158878008177 GTP/Mg2+ binding site [chemical binding]; other site 158878008178 Switch I region; other site 158878008179 G2 box; other site 158878008180 Switch II region; other site 158878008181 G3 box; other site 158878008182 G4 box; other site 158878008183 G5 box; other site 158878008184 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 158878008185 ribonuclease P; Reviewed; Region: rnpA; PRK00499 158878008186 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 158878008187 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 158878008188 MobA/MobL family; Region: MobA_MobL; pfam03389 158878008189 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158878008190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158878008191 non-specific DNA binding site [nucleotide binding]; other site 158878008192 salt bridge; other site 158878008193 sequence-specific DNA binding site [nucleotide binding]; other site 158878008194 TM2 domain; Region: TM2; pfam05154 158878008195 DMAP1-binding Domain; Region: DMAP_binding; pfam06464 158878008196 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 158878008197 DNA-binding interface [nucleotide binding]; DNA binding site 158878008198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 158878008199 Integrase core domain; Region: rve; pfam00665 158878008200 multiple promoter invertase; Provisional; Region: mpi; PRK13413 158878008201 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 158878008202 catalytic residues [active] 158878008203 catalytic nucleophile [active] 158878008204 Presynaptic Site I dimer interface [polypeptide binding]; other site 158878008205 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 158878008206 Synaptic Flat tetramer interface [polypeptide binding]; other site 158878008207 Synaptic Site I dimer interface [polypeptide binding]; other site 158878008208 DNA binding site [nucleotide binding] 158878008209 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 158878008210 DNA-binding interface [nucleotide binding]; DNA binding site 158878008211 YolD-like protein; Region: YolD; pfam08863 158878008212 Predicted membrane protein [Function unknown]; Region: COG4640 158878008213 Predicted membrane protein [Function unknown]; Region: COG4640 158878008214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 158878008215 Integrase core domain; Region: rve; pfam00665 158878008216 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 158878008217 Integrase core domain; Region: rve; pfam00665 158878008218 Transposase, Mutator family; Region: Transposase_mut; pfam00872 158878008219 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 158878008220 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 158878008221 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 158878008222 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 158878008223 Phosphotransferase enzyme family; Region: APH; pfam01636 158878008224 active site 158878008225 ATP binding site [chemical binding]; other site 158878008226 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 158878008227 substrate binding site [chemical binding]; other site 158878008228 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158878008229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158878008230 Coenzyme A binding pocket [chemical binding]; other site 158878008231 Transposase, Mutator family; Region: Transposase_mut; pfam00872 158878008232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 158878008233 Integrase core domain; Region: rve; pfam00665 158878008234 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 158878008235 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 158878008236 catalytic residues [active] 158878008237 catalytic nucleophile [active] 158878008238 Presynaptic Site I dimer interface [polypeptide binding]; other site 158878008239 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 158878008240 Synaptic Flat tetramer interface [polypeptide binding]; other site 158878008241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158878008242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158878008243 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 158878008244 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158878008245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158878008246 putative substrate translocation pore; other site 158878008247 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196