-- dump date 20140620_074536 -- class Genbank::CDS -- table cds_note -- id note NP_373239.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. NP_373240.1 binds the polymerase to DNA and acts as a sliding clamp NP_373242.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA NP_373246.2 catalyzes the degradation of histidine to urocanate and ammmonia NP_373247.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_373248.1 hypothetical protein, similar to amino acid permease NP_373250.1 hypothetical protein, similar to homoserine-o-acetyltransferase NP_373253.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk NP_373255.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis NP_373261.1 hypothetical protein, similar to 5'-nucleotidase NP_373262.1 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA NP_373276.2 glycerophosphoryldiester phosphodiesterase homologue NP_373281.1 xylose repressor homologue NP_373293.1 truncated hypothetical protein, similar to DNA repair protein NP_373302.1 (fragment) NP_373304.2 hypothetical protein, similar to transposase NP_373306.1 hypothetical protein, similar to kdp operon transcriptional regulatory protein NP_373307.1 hypothetical protein, similar to kdp operon sensor protein NP_373308.2 potassium-transporting ATPase A chain homologue; catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions NP_373310.1 potassium-transporting ATPase B chain homologue; one of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions NP_373311.1 potassium-transporting ATPase C chain homologue NP_373318.1 hypothetical protein, similar to serine/threonine protein kinase NP_373325.1 hypothetical protein, similar to homo sapiens CGI-44 protein, PRO1975 protein NP_373330.1 hypothetical protein, similar to DNA helicase NP_373338.1 Uncharacterized HTH-type transcriptional regulator SA0097. NP_373339.1 hypothetical protein, similar to aminoacylase NP_373340.1 hypothetical protein, similar to transmembrane efflux pump protein NP_373343.1 SA0102; in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever NP_373345.1 HTH-type transcriptional regulator norG. NP_373347.1 L-lactate permease homologue NP_373349.1 staphylococcal accessory regulator A homologue NP_373353.1 hypothetical protein, similar to cysteine synthase NP_373354.1 hypothetical protein, similar to ornithine cyclodeaminase NP_373356.1 hypothetical protein, similar to multi-drug resistance efflux pump NP_373357.1 hypothetical protein, similar to rhizobactin siderophore biosynthesisprotein RhsC NP_373358.1 hypothetical protein, similar to rhizobactin siderophore biosynthesisprotein RhsF NP_373359.1 hypothetical protein, similar to various aldolase NP_373360.1 hypothetical protein, similar to diaminopimelate decarboxylase NP_373365.1 hypothetical protein, similar to UDP-glucose 4-epimerase (gale-1) NP_373366.1 hypothetical protein, similar to glycosyltransferase TuaA NP_373367.1 hypothetical protein, similar to Eps(Exopolysaccharide)G NP_373368.1 hypothetical protein, similar to capsular polysaccharide synthesis protein 14H NP_373369.1 hypothetical protein, similar to capsular polysaccharide synthesis protein 14L NP_373372.1 hypothetical protein, similar to trehalose operon transcriptional repressor NP_373373.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate NP_373374.1 hypothetical protein, similar to tetracyclin resistance protein NP_373375.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate NP_373376.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose NP_373377.1 hypothetical protein, similar to phosphonates transport permease NP_373378.1 hypothetical protein, similar to phosphonates transport permease NP_373379.1 Phosphonates import ATP-binding protein phnC NP_373380.1 hypothetical protein, similar to alkylphosphonate ABC tranporter NP_373382.1 hypothetical protein, similar to lactococcal phosphatase homologue NP_373384.1 hypothetical protein, similar to DNA-binding protein NP_373402.1 iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source NP_373404.1 aldehyde dehydrogenase homologue NP_373405.1 hypothetical protein, similar to cation-efflux system membrane protein CzcD NP_373408.1 hypothetical protein, similar to alpha-helical coiled-coil protein SrpF NP_373409.1 hypothetical protein, similar to nitrate transporter NP_373410.1 hypothetical protein, similar to membrane lipoprotein SrpL NP_373411.1 hypothetical protein, similar to probable permease of ABC transporter NP_373412.1 hypothetical protein, similar to acyl-CoA dehydrogenase NP_373414.1 Catalyzes the reversible two-electron oxidation of formate to carbon dioxide. It allows the assimilation of carbon dioxide and provides energy for growth through oxidative phosphorylation coupled to the reduction of oxygen, nitrate, sulphate or fumarate NP_373415.1 hypothetical protein, similar to integral membrane protein LmrP NP_373416.1 hypothetical protein, similar to surfactin synthetase NP_373419.1 Acetylglutamate kinase NP_373420.1 arginine biosynthesis bifunctional protein homologue; bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate NP_373421.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate NP_373423.1 hypothetical protein, similar to branched-chain amino acid transport system carrier protein NP_373424.1 hypothetical protein, similar to isochorismatase NP_373425.1 hypothetical protein, similar to indole-3-pyruvate decarboxylas NP_373426.1 PTS enzyme II (EC 2.7.1.69), glucose-specific, factor IIA homologue NP_373428.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway NP_373429.1 PTS system EIIBC component SA0186 [Includes: Phosphotransferase enzyme IIB component NP_373430.1 hypothetical protein, similar to transcription regulator NP_373435.1 hypothetical protein, similar to ABC transporter ATP-binding protein NP_373436.1 hypothetical protein, similar to Enterococcus faecalis plasmid pPD1 bacI NP_373440.1 hypothetical protein, similar to ABC transporter ATP-binding protein NP_373443.1 truncated hypothetical protein, similar to oligopeptide ABC transporter permease NP_373444.1 hypothetical protein, similar to dipeptide transporter protein dppC NP_373446.1 hypothetical protein, similar to gamma-glutamyltranspeptidase precursor NP_373448.1 SA0204; FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds NP_373449.1 hypothetical protein, similar to lysostaphin precursor NP_373451.1 hypothetical protein, similar to maltose/maltodextrin-binding protein NP_373452.1 maltose/maltodextrin transport permease homologue NP_373453.1 maltose/maltodextrin transport permease homologu NP_373454.1 hypothetical protein, similar to NADH-dependent dehydrogenase NP_373455.1 hypothetical protein, similar to NADH-dependent dehydrogenase NP_373458.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate NP_373459.1 Uncharacterized response regulatory protein SA0215. NP_373460.1 Uncharacterized sensor-like histidine kinase SA0216 NP_373461.1 hypothetical protein, similar to periplasmic-iron-binding protein BitC NP_373464.1 hypothetical protein, similar to glycerophosphodiester phosphodiesterase NP_373467.1 acetyl-CoA acetyltransferase homologue NP_373468.1 hypothetical protein, similar to 3-hydroxyacyl-CoA dehydrogenase NP_373469.1 hypothetical protein, similar to glutaryl-CoA dehydrogenase NP_373470.1 hypothetical protein, similar to acid-CoA ligase NP_373473.1 hypothetical protein, similar to nickel ABC transporter nickel-binding protein NP_373476.1 hypothetical protein, similar to flavohemoprotein NP_373478.1 PTS enzyme (EC 2.7.1.69), maltose- and glucose-specific, factor II homologue NP_373479.1 hypothetical protein, similar to inosine-uridine preferring nucleoside hydrolase NP_373480.1 hypothetical protein, similar to BglG antiterminator family NP_373481.1 hypothetical protein, similar to PTS fructose-specific enzyme IIBC component NP_373482.1 hypothetical protein, similar to PTS, galactitol-specific IIB component NP_373486.1 sorbitol dehydrogenase homologue NP_373487.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1; 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers NP_373488.1 hypothetical protein, similar to xylitol dehydrogenase NP_373489.1 hypothetical protein, similar to teichoic acid biosynthesis protein B NP_373490.1 hypothetical protein, similar to teichoic acid biosynthesis protein F NP_373491.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers NP_373492.1 hypotheticl protein, similar to D-xylulose reductase NP_373493.1 hypothetical protein, similar to teichoic acid biosynthesis protein B NP_373494.1 hypothetical protein, similar to beta-glycosyltransferase NP_373495.1 involved in peptidoglycan cross-linking NP_373498.1 negatively regulates murein hydrolase activity NP_373499.1 in conjunction with LrgA this protein inhibits the expression or activity of extracellular murein hydrolases NP_373500.1 hypothetical protein, similar to transcription regulator GntR family NP_373501.1 hypothetical protein, similar to PTS beta-glucoside-specific enzyme II, ABC component NP_373505.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source NP_373506.1 ribose uptake protein rbsU. NP_373507.1 hypothetical protein, similar to rbs operon repressor RbsR NP_373509.1 hypothetical protein, similar to proton antiporter efflux pump NP_373510.1 hypothetical protein, similar to penicillin amidase (EC 3.5.1.11) V NP_373516.1 hypothetical protein, similar to secretory antigen precursor SsaA NP_373518.1 Protein esaA. NP_373522.1 Protein essC. NP_373539.1 hypothetical protein, similar to formate transporter NirC NP_373540.1 hypothetical protein, similar to branched-chain amino acid uptake carrier NP_373541.1 hypothetical protein, similar to outer membrane protein precursor NP_373543.1 hypothetical protein, similar to ABC transporter ATP-binding protein NP_373544.1 hypothetical protein, similar to regulatory protein PfoR NP_373545.1 hypothetical protein, similar to carbohydrate kinase, PfkB family NP_373549.1 hypothetical protein, similar to sodium-coupled permease NP_373550.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid NP_373551.1 hypothetical protein, similar to glucokinase NP_373553.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate NP_373557.1 hypothetical protein, similar to trimethylamine dehydrogenase (EC 1.5.99.7) NP_373558.1 hypothetical protein, similar to alkanal monooxygenase alpha chain NP_373559.1 hypothetical protein, similar to glycine cleavage system H protein NP_373562.1 hypothetical protein, similar to lipoate-protein ligase NP_373563.1 hypothetical protein, similar to dihydroflavonol-4-reductase NP_373564.1 hypothetical protein, similar to transport protein SgaT; membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr NP_373566.1 hypothetical protein, similar to PTS fructose-specific enzyme IIBC component NP_373567.1 hypothetical protein, similar to transcription antiterminator BglG family NP_373568.1 hypothetical protein, similar to transcription regulator NP_373574.1 hypothetical protein, similar to NADH-dependent FMN reductase NP_373576.1 hypothetical protein, similar to ribosomal-protein-serine N-acetyltransferase NP_373583.1 hypothetical protein, similar to transcriptional repressor NP_373585.1 hypothetical protein, similar to ABC transporter ATP-binding protein NP_373587.1 hypothetical protein, similar to low temperature requirement A protein NP_373588.1 acetyl-CoA C-acetyltransferase homologue NP_373590.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine NP_373591.1 catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions NP_373592.1 hypothetical protein, similar to cystathionine beta-lyase NP_373593.1 hypothetical protein, similar to cystathionine gamma-synthase NP_373594.1 hypothetical protein, similar to transcription terminator NP_373597.1 hypothetical protein, similar to GTP-binding protein; translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 NP_373599.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 NP_373601.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit NP_373602.1 hypothetical protein, similar to hypothetical protein virulence plasmid pXO1-38 NP_373604.1 hypothetical protein, similar to exotoxin 2 NP_373610.1 truncated hypothetical protein, similar to phosphoglycerate mutase; Gpm3p NP_373616.1 NADPH-dependent oxidoreductase NP_373617.1 hypothetical protein, similar to proton/sodium-glutamate symport protein NP_373622.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine NP_373625.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway NP_373632.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_373633.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_373634.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_373635.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_373636.1 SSL5, SET3, SET10; bind P-selectin glycoprotein ligand-1 and inhibit P-selectin-mediated neutrophil rolling along the endothelium; these proteins share structural homology to known superantigens but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_373637.1 SSL7, SET1; blocks IgA-FcR interactions and inhibits complement, leading to increased survival of a sensitive bacterium in blood NP_373638.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_373639.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_373640.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_373644.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_373663.1 Catalyzes the transfer of electrons from NADH to ubiquinone NP_373668.1 hypothetical protein, similar to carboxylesterase NP_373669.1 hypothetical protein, similar to sodium-dependent transporter NP_373670.1 cysteine synthase homologue NP_373672.1 Methionine import ATP-binding protein metN 1 NP_373673.1 hypothetical protein, similar to ABC transporter permease NP_373674.1 hypothetical protein, similar to lactococcal lipoprotein NP_373675.1 N-acetylmuramoyl-L-alanine amidase sle1 precursor NP_373683.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate NP_373686.1 hypothetical protein, similar to trehalose operon transcriptional repressor NP_373690.1 involved in a recombinational process of DNA repair, independent of the recBC complex NP_373691.1 hypothetical protein, similar to lysine decarboxylase NP_373692.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) NP_373695.1 hypothetical protein, similar to signal peptidase II homologue NP_373696.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA NP_373700.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content NP_373703.1 dimethyladenosine transferase(16S rRNA dimethylase) homologue; catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin NP_373704.1 VEG protein homologue NP_373705.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis NP_373706.1 pur operon repressor homologue NP_373707.1 translation initiation inhibitor homologue NP_373708.2 stage V sporulation protein G homologue; stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus NP_373709.1 UDP-N-acetylglucosamine pyrophosphorylase homologue; forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis NP_373710.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP NP_373711.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response NP_373712.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation NP_373714.1 hypothetical protein, similar to low temperature requirement B protein NP_373717.1 hypothetical protein, similar to cell-division initiation protein NP_373718.1 hypothetical protein, similar to polyribonucleotide nucleotidyltransferase NP_373720.1 hypoxanthine-guanine phosphoribosyltransferase homologue NP_373721.1 (ATP-dependent Zn metallopeptidase) NP_373722.1 heat-shock protein HSP33 homologue; becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers NP_373723.1 cysteine synthase (o-acetylserine sulfhydrylase) homologue NP_373727.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 NP_373728.1 hypothetical protein, similar to transcription regulator GntR family NP_373729.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate NP_373730.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate NP_373732.1 transcription repressor of class III stress genes homologue NP_373734.1 ATP:guanido phosphotransferase SA0482 NP_373736.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents NP_373738.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation NP_373739.1 Serine acetyltransferase homologue NP_373740.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA NP_373742.1 trmH family tRNA/rRNA methyltransferase NP_373745.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force NP_373748.1 binds directly to 23S ribosomal RNA NP_373749.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA NP_373750.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit NP_373751.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors NP_373753.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme NP_373754.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter NP_373755.1 in Bacillus subtilis this non-essential protein associates with the ribosome NP_373756.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance NP_373757.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit NP_373758.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene NP_373759.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu NP_373760.1 hypothetical protein, similar to N-acyl-L-amino acid amidohydrolase NP_373761.2 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine NP_373762.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress NP_373763.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate NP_373764.1 Uncharacterized epimerase/dehydratase SA0511. NP_373765.1 branched-chain amino acid aminotroansferase homologue; catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids NP_373767.1 hypothetical protein, similar to deoxypurine kinase NP_373768.1 hypothetical protein, similar to deoxypurine kinase NP_373769.1 hypothetical protein, similar to Cu binding protein (Mn oxidation NP_373775.1 hypothetical protein, similar to poly (glycerol-phosphate) alpha-glucosyltransferase (teichoic acid biosynthesis) NP_373776.1 hypothetical protein, similar to poly (glycerol-phosphate) alpha-glucosyltransferase (teichoic acid biosynthesis) NP_373777.1 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis NP_373781.1 3-hexulose-6-phosphate synthase NP_373783.1 hypothetical protein, similar to indigoidine systhesis protein NP_373784.1 proline/betaine transporter homologue NP_373786.1 long chain fatty acid-CoA ligase vraA NP_373791.1 hypothetical protein, similar to phosphomethylpyrimidine kinase, thiD homologue NP_373792.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine NP_373795.1 hypothetical protein, similar to cationic amino acid transporter NP_373799.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta NP_373805.1 mercuric reductase homologue NP_373811.1 hypothetical protein, similar to oxidoreductase, ion channel NP_373816.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs NP_373818.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase NP_373819.1 hypothetical protein, similar to endonuclease III NP_373820.1 hypothetical protein, similar to iron-binding protein NP_373821.1 hypothetical protein, similar to iron(III) ABC transporter permease NP_373822.1 hypothetical protein, similar to L-2-haloalkanoic acid dehalogenase NP_373823.1 hypothetical protein similar to 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase NP_373826.1 hypothetical protein, similar to esterase/lipase NP_373831.1 hypothetical protein, similar to FimE recombinase NP_373832.1 SA0578; subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_373833.1 hypothetical protein, similar to Na+/H+ antiporter; subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_373834.1 hypothetical protein, similar to Na+/H+ antiporter; subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_373835.1 SA0581; subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; in S. meliloti it is known to be involved specifically with K+ transport NP_373836.1 hypothetical protein, similar to Na+/H+ antiporter; subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport NP_373837.1 hypothetical protein, similar to Na+/H+ antiporter; subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_373838.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_373841.1 lipoprotein, Streptococcal adhesin PsaA homologue NP_373843.1 hypothetical protein, similar to ABC transporter ATP-binding protein NP_373844.1 hypothetical protein, similar to iron dependent repressor NP_373847.1 with TagG is involved in the export of teichoic acids NP_373855.1 hypothetical protein, similar to pyrimidine nucleoside transporter NP_373860.1 hypothetical protein, similar to dihydroxyacetone kinase; with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase NP_373865.1 hypothetical protein, similar to lipase LipA NP_373869.1 hypothetical protein, similar to two-component response regulator NP_373870.1 hypothetical protein, similar to two-component sensor histidine kinas NP_373874.1 hypothetical protein, similar to low-affinity inorganic phosphate transporter NP_373875.1 secretory antigen SsaA homologue NP_373877.1 hypothetical protein, similar to AraC/XylS family transcriptional regulator NP_373882.1 hypothetical protein, similar to LysR family transcriptional regulator NP_373883.1 hypothetical protein, similar to sugar efflux transpoter NP_373893.1 bacitracin resistance protein ( undecaprenol kinase) homologue; BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell NP_373894.1 hypothetical protein, similar to ABC transporter required for expression of cytochrome bd NP_373895.1 hypothetical protein, similar to ABC transporter required for expression of cytochrome bd NP_373896.1 HTH-type transcriptional regulator mgrA. NP_373897.1 hypothetical protein, similar to cobalamin synthesis related protein NP_373898.1 hypothetical protein, similar to aryl-alcohol dehydrogenase NP_373901.1 hypothetical protein, similar to deoxyribodipyrimidine photolyase NP_373907.1 hypothetical protein, similar to transcription regulation protein NP_373908.1 hypothetical protein, similar to transcription repressor of fructose operon NP_373912.1 hypothetical protein, similar to hemolysin homologue NP_373913.1 hypothetical protein, similar to plant-metabolite dehydrogenases NP_373914.1 hypothetical protein, similar to CsbB stress response protein NP_373920.1 coenzyme PQQ synthesis homologue NP_373921.1 6-pyruvoyl tetrahydrobipterin synthase homologue NP_373923.1 similar to anthranilate synthase component II NP_373924.1 similar to para-aminobenzoate synthase component I NP_373925.1 hypothetical protein, similar to para-aminobenzoate synthase component I NP_373927.1 hypothetical protein, similar to urea amidolyase NP_373929.1 Glycerol phosphate lipoteichoic acid synthase NP_373930.1 hypothetical protein, similar to ABC transporter ATP-binding protein NP_373932.1 hypothetical protein, similar to choline transport ATP-binding protein NP_373933.1 hypothetical protein, similar to choline transporter NP_373934.1 Histidinol-phosphate aminotransferase; catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis NP_373936.1 hypothetical protein, similar to multidrug resistance protein NP_373937.1 hypothetical protein, similar to di-tripepride ABC transporter NP_373938.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis NP_373940.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF NP_373941.1 Catalyzes the rate-limiting step in dNTP synthesis NP_373942.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE NP_373943.1 hypothetical protein, similar to ferrichrome ABC transporter permease NP_373944.1 hypothetical protein, similar to ferrichrome ABC transporter permease NP_373945.1 hypothetical protein, similar to ferrichrome ABC transporter ATP-binding protein NP_373946.1 lipoprotein, similar to ferrichrome ABC transporter NP_373948.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis NP_373952.1 hypothetical protein, similar to glycerate kinase NP_373953.1 catalyzes the release of the N-terminal amino acid from a tripeptide NP_373960.1 hypothetical protein, similar to comF operon protein 1 NP_373961.1 hypothetical protein, similar to comF operon protein 3 NP_373963.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins NP_373964.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 NP_373968.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion NP_373969.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate NP_373970.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system NP_373971.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein NP_373972.1 acetyltransferase SA0717 NP_373978.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates NP_373979.1 hypothetical protein, similar to cell-division inhibitor NP_373983.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway NP_373984.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate NP_373985.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate NP_373986.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_373989.1 carboxyesterase precursor homologue NP_373991.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation NP_373998.1 hypothetical protein, similar to staphylocoagulase precursor NP_374000.1 hypothetical protein, similar to extracellular matrix and plasma binding NP_374010.1 hypothetical protein, similar to phosphoglycerate mutase NP_374012.1 hypothetical protein, similar to lactococcal prophage ps3 protein 05 NP_374014.1 Organic hydroperoxide resistance protein-like. NP_374015.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis NP_374017.1 hypothetical protein, similar to thioredoxin NP_374018.1 hypothetical protein, similar to arsenate reductase NP_374019.1 glycine cleavage system protein H homologue; part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor NP_374029.1 hypothetical protein, similar to thioredoxin NP_374030.1 SA0769 NP_374035.1 SA0774 NP_374037.1 aminotransferase NifS homologue NP_374038.1 hypothetical protein, similar to nitrogen fixation protein NifU NP_374041.1 hypothetical protein, similar to hemolysin NP_374042.1 hypothetical protein, similar to 2-nitropropane dioxygenase NP_374046.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group NP_374051.1 Protein nagD homolog. NP_374052.1 hypothetical protein, similar to glycerate dehydrogenase NP_374054.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid NP_374056.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid NP_374058.1 hypothetical protein, similar to nitrogen fixation protein NifU NP_374060.1 hypothetical protein, similar to NADH dehydrogenase NP_374063.1 NADH dehydrogenase-like protein SA0802 NP_374068.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_374069.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_374070.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_374071.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone NP_374072.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_374073.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in the case of S. meliloti it was proved to be involved specifically with K+ transport NP_374074.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_374076.1 peptidyl-prolyl cis-trans isomerase homologue NP_374077.1 hypothetical protein, similar to polyribonucleotide nucleotidyltransferase NP_374078.1 hypothetical protein, similar to NADH-dependent flavin oxidoreductase NP_374082.1 catalyzes the formation of arginine from (N-L-arginino)succinate NP_374083.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming NP_374084.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family NP_374088.1 hypothetical protein, similar to ATP-dependent nuclease subunit B NP_374089.1 hypothetical protein, similar to ATP-dependent nuclease subunit A NP_374090.1 hypothetical protein, similar to 5-oxo-1,2,5-tricarboxilic-3-penten acid decarboxylase NP_374092.1 NADPH-dependent; catalyzes the reduction of coenzyme A disulfide NP_374096.1 O-acetyltransferase SA0834 NP_374097.1 ClpB chaperone homologue NP_374098.1 hypothetical protein, similar to transcription regulator LysR family NP_374099.1 hypothetical protein, similar to 2-isopropylmalate synthase NP_374103.1 hypothetical protein, similar to cell surface protein Map-w NP_374105.1 FabH, 3-oxoacyl-(acyl-carrier protein) synthase homologue; FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs NP_374109.1 hypothetical protein, similar to oligopeptide transport system permease OppC NP_374110.1 oligopeptide transport system ATP-binding protein OppD homologue NP_374111.1 oligopeptide transport system ATP-binding protein OppF homologue NP_374112.1 hypothetical protein, similar to peptide binding protein OppA NP_374113.1 hypothetical protein, similar to oligopeptide ABC transporter oligopeptide-binding protein NP_374114.1 oligopeptide ABC transporter ATP-binding protein homologue NP_374115.1 oligopeptide transport system ATP-binding protein AppF homologue NP_374117.1 Hypothetical protein, similar to oligopeptide transport system permease OppC NP_374118.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_374119.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress NP_374120.1 Adapter protein mecA; enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence NP_374121.1 hypothetical protein, similar to transcription factor NP_374122.1 thimet oligopeptidase homologue NP_374128.1 catalyzes the phosphorylation of NAD to NADP NP_374130.1 hypothetical protein, similar to Mg2+ transporter NP_374131.1 Na+/H+ antiporter homologue NP_374132.1 Catalyzes a key regulatory step in fatty acid biosynthesis NP_374134.1 hypothetical protein, similar to Na+/H+-dependent alanine carrier protein NP_374136.1 similar to 2'-5' RNA ligase NP_374137.1 Probable glycolipid permease ltaA (Lipoteichoic acid protein A). NP_374138.1 Processive diacylglycerol glucosyltransferase; processive; catalyzes the formation of mono-, di- and tri-glucosyldiacylglycerol by the progressive transfer of glucosyl residues to diacylglycerol; involved in the formation of membrane glycolipids NP_374139.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine NP_374141.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein NP_374142.1 toxic anion resistance protein homologue NP_374144.1 hypothetical protein, similar to Na+-transporting ATP synthase NP_374145.1 hypothetical protein, similar to nucleotidase NP_374146.1 hypothetical protein, similar to competence transcription factor NP_374148.1 lipoate-protein ligase homolog NP_374152.1 hypothetical protein, similar to lactococcin 972 NP_374153.1 hypothetical protein, similar to lactococcin 972 immunity factor NP_374158.1 hypothetical protein, similar to ferrichrome ABC transporter NP_374161.1 hypothetical protein, similar to 1,4-dihydroxy-2-naphthodate octaprenyltransferase; catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate NP_374162.1 hypothetical protein, similar to menaquinone-specific isochorismate synthase NP_374164.1 hypothetical protein, similar to prolyl aminopeptidase NP_374165.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA NP_374169.1 HisC homolog NP_374177.1 Probable quinol oxidase subunit 4 NP_374180.1 Probable quinol oxidase subunit 2 precursor NP_374181.1 hypothetical protein, similar to chitinase B NP_374182.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate NP_374183.1 hypothetical protein, similar to phosphoribosylaminoimidazole carboxylase PurE NP_374184.1 phosphoribosylaminoimidazole carboxylase carbon dioxide-fixation chain PurK homolog; With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway NP_374185.1 phosphoribosylaminoimidazolesuccinocarboxamide synthetase homolog; catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase NP_374187.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis NP_374188.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis NP_374189.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway NP_374190.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis NP_374192.1 involved in de novo purine biosynthesis NP_374193.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis NP_374195.1 hypothetical protein, similar to cation ABC transporter NP_374205.1 cytochrome D ubiquinol oxidase subunit 1 homolog NP_374206.1 cytochrome D ubiquinol oxidase subunit II homolog NP_374210.1 formylmethionine deformylase homolog; cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_374214.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide NP_374217.1 spermidine/putrescine ABC transporter, ATP-binding protein homolog NP_374219.1 spermidine/putrescine ABC transporter homolog NP_374220.1 spermidine/putrescine-binding protein precursor homolog NP_374223.1 Probable manganese transport protein mntH. NP_374225.1 myo-inositol-1(or 4)-monophosphatase homolog NP_374227.1 GTP-binding elongation factor homolog NP_374230.1 depletion of this protein in Bacillus subtilis results in defects in cell morphology; crystal structure of Staphylococcus protein shows homodimer; ligand binding protein NP_374232.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate NP_374233.1 hypothetical protein, similar to heme synthase NP_374234.1 cytochrome caa3 oxidase (assembly factor) homolog; converts protoheme IX and farnesyl diphosphate to heme O NP_374238.1 hypothetical protein, similar to glycerophosphoryl diester phosphodiesterase NP_374242.1 phosphopantetheine adenyltransferase homolog; Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA NP_374245.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not NP_374250.1 hypothetical protein, similar to ferrichrome ABC transporter NP_374251.1 hypothetical protein, similar to ferrichrome ABC transporter NP_374253.2 iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source NP_374254.1 hypothetical protein, similar to rRNA methylase NP_374255.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily NP_374256.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily NP_374257.1 Ribonuclease HIII; An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids NP_374261.1 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange NP_374263.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision NP_374265.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol NP_374266.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase NP_374267.1 converts L-glutamate to D-glutamate, a component of peptidoglycan NP_374268.1 hydrolyzes non-standard nucleotides such as xanthine and inosine NP_374271.1 hypothetical protein, similar to fibrinogen-binding protein NP_374272.1 FLIPr; secreted protein that blocks the formyl peptide receptor-like 1 (FPRL1) found in neutrophils, monocytes, B cells, and NK cells; inhibits the binding of chemoattractants (such as formylated peptides) to FPRL1, which initiates the phagocyte mobilization towards the infection site NP_374274.1 Fibrinogen-binding protein precursor. NP_374275.1 hypothetical protein, similar to fibrinogen-binding protein NP_374282.1 hypothetical protein, similar to exotoxin 1; these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_374283.1 hypothetical protein, similar to exotoxin 4; these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_374284.1 hypothetical protein, similar to exotoxin 3; these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation NP_374285.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation NP_374286.1 Carbamate kinase 1; catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP NP_374294.1 MraZ; UPF0040; crystal structure shows similarity to AbrB NP_374298.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan NP_374299.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation NP_374300.1 cell division protein, FtsQ homolog NP_374302.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function NP_374307.1 hypothetical protein, similar to cell-division protein NP_374308.1 hypothetical protein, similar to cell-divisio initiation protein NP_374309.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme NP_374312.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis NP_374314.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity NP_374316.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis NP_374317.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis NP_374318.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers NP_374319.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity NP_374320.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase NP_374321.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate NP_374324.1 hypothetical protein, similar to fibrinogen binding protein NP_374325.1 guanylate kinase homolog; Essential for recycling GMP and indirectly, cGMP NP_374326.1 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits NP_374327.1 pantothenate metabolism flavoprotein homolog NP_374331.1 Peptide deformylase-like (Polypeptide deformylase-like); cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_374333.1 hypothetical protein, similar to RNA-binding Sun protein NP_374334.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance NP_374338.1 ribulose-5-phosphate 3-epimerase homolog NP_374340.1 required for 70S ribosome assembly NP_374343.1 catalyzes branch migration in Holliday junction intermediates NP_374344.1 negative regulator of genes involved in fatty acid and phospholipid biosynthesis for gram positive bacteria NP_374345.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY NP_374348.1 carries the fatty acid chain in fatty acid biosynthesis NP_374349.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity NP_374353.1 signal recognition particle homolog NP_374354.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity NP_374355.1 Essential for efficient processing of 16S rRNA NP_374356.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA NP_374357.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site NP_374359.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) NP_374360.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids NP_374361.1 catalyzes the interconversion of succinyl-CoA and succinate NP_374362.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle NP_374365.1 hypothetical protein, similar to DNA processing Smf protein NP_374366.1 DNA topoisomerase I topA homolog; catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity NP_374367.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine NP_374368.1 site-specific recombinase XerC homolog NP_374369.1 heat shock protein involved in degradation of misfolded proteins NP_374370.1 heat shock protein involved in degradation of misfolded proteins NP_374371.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor NP_374372.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit NP_374373.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu NP_374374.1 Catalyzes the phosphorylation of UMP to UDP NP_374375.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs NP_374376.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate NP_374379.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) NP_374380.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity NP_374381.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins NP_374382.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination NP_374384.1 hypothetical protein, similar to ribosomal protein L7AE family NP_374385.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex NP_374386.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock NP_374387.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs NP_374389.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence NP_374392.1 sporulation-related protein SpoIIIE homolog NP_374393.1 hypothetical protein, similar to transcription regulator GntR family NP_374394.1 hypothetical protein, similar to processing proteinase homolog NP_374395.1 hypothetical protein, similar to precessing proteinase NP_374396.1 hypothetical protein, similar to 3-oxoacyl- acyl-carrier protein reductase homolog ymfI NP_374401.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs NP_374402.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP NP_374405.1 hypothetical protein, similar to 2-oxoacid ferredoxin oxidoreductase, alpha subunit NP_374406.1 hypothetical protein, similar to 2-oxoacid ferredoxin oxidoreductase, beta subunit; catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin NP_374408.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) NP_374411.1 This protein performs the mismatch recognition step during the DNA repair process NP_374412.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex NP_374416.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP NP_374418.1 hypothetical protein, similar to lysophospholipase NP_374419.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity NP_374420.1 hypothetical protein, similar to host factor-1 NP_374422.1 hypothetical protein, similar to GTP-binding protein proteinase modulator homolog ynbA NP_374423.1 hypothetical protein, similar to aluminum resistance protein NP_374432.1 cardiolipin synthetase homolog NP_374433.1 ABC transporter (ATP-binding protein) homolog NP_374434.1 hypothetical protein, similar to ABC transporter integral membrane protein NP_374435.1 hypothetical protein, similar to two-component sensor histidine kinase NP_374436.1 hypothetical protein, similar to two-component response regulator NP_374441.1 aspartate kinase homolog; catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive NP_374442.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine NP_374443.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine NP_374444.1 homoserine kinase homolog; catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate NP_374449.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_374450.1 30S ribosomal protein S14 homolog; located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif NP_374451.1 GMP reductase NP_374453.1 Represses a number of genes involved in the response to DNA damage NP_374459.1 hypothetical protein, similar to exonuclease SbcD NP_374460.1 hypothetical protein, similar to exonuclease SbcC NP_374461.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock NP_374463.1 Catalyzes the conversion of citrate to isocitrate NP_374467.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_374468.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_374474.1 peptide methionine sulfoxide reductase homolog; this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress NP_374477.1 hypothetical protein, similar to DNA-damage repair protein NP_374478.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate NP_374479.1 hypothetical protein, similar to glucanase NP_374480.1 hypothetical protein, similar to anthranilate synthase component I; with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine NP_374482.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate NP_374483.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water NP_374484.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis NP_374485.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate NP_374486.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis NP_374497.1 hypothetical protein, similar to oligoendopeptidase NP_374498.1 hypothetical protein, similar to negative regulator PhoU NP_374499.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation NP_374500.1 hypothetical protein, similar to phosphate ABC transporter NP_374501.1 hypothetical protein, similar to phosphate ABC transporter NP_374505.1 ABC transporter (ATP-binding protein) homolog NP_374506.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. NP_374508.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis NP_374509.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis NP_374512.1 Alanine racemase 2 NP_374517.1 catalyzes the hydrolysis of acylphosphate NP_374518.1 hypothetical protein, similar to 5-bromo-4-chloroindolyl phosphate hydrolysis protein xpaC NP_374519.1 TelA-like protein SA1238. NP_374522.1 hypothetical protein, similar to nitric-oxide reductase NP_374524.1 ABC transporter homolog NP_374525.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA NP_374526.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide NP_374532.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis NP_374537.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress NP_374538.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress NP_374541.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived NP_374547.1 hypothetical protein, similar to cell wall enzyme EbsB NP_374548.1 hypothetical protein, similar to streptococcal adhesin emb NP_374549.1 hypothetical protein, similar to streptococcal adhesin emb NP_374551.1 hypothetical protein, similar to amino acid pearmease NP_374552.1 threonine deaminase IlvA homolog; catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic NP_374554.1 hypothetical protein, similar to 5'-3' exonuclease NP_374563.1 recombination protein U homolog; functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC NP_374567.1 hypothetical protein, similar to chromosome replication initiation protein dnaD NP_374568.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_374570.1 hypothetical protein, similar to bifunctional biotin ligase/biotin operon repressor NP_374571.1 CCA-adding enzyme; catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity NP_374572.1 hypothetical protein, similar to lipopolysaccharide biosynthesis-related pr homolog NP_374578.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis NP_374579.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis NP_374580.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis NP_374583.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate NP_374585.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone NP_374586.1 hypothetical protein, similar to component A of hexaprenyl diphosphate synthase NP_374588.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate NP_374589.1 GTP-binding protein engA; EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains NP_374590.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins NP_374592.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP NP_374594.1 hypothetical protein, similar to thioredoxin reductase homolog NP_374612.1 ferric uptake regulator homolog NP_374616.1 hypothetical protein, similar to oxidoreductase NP_374617.1 Pyrroline-5-carboxylate reductase NP_374619.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate NP_374620.1 transcription regulator AraC/XylS family homolog NP_374624.1 hypothetical protein, similar to export protein SpcT protein NP_374625.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate NP_374626.1 hypothetical protein, similar to tripeptidase NP_374634.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes NP_374635.1 geranyltranstransferase homolog NP_374636.1 Exodeoxyribonuclease 7 small subunit; catalyzes the bidirectional exonucleolytic cleavage of DNA NP_374637.1 Exodeoxyribonuclease 7 large subunit; bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides NP_374638.1 N utilization substance protein B homolog (Protein nusB); Regulates rRNA biosynthesis by transcriptional antitermination NP_374640.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism NP_374642.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA NP_374648.1 glycine dehydrogenase (decarboxylating) subunit 2 homolog; acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein NP_374649.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein NP_374650.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein NP_374651.1 Shikimate kinase NP_374652.1 hypothetical protein, similar to ComYC protein NP_374654.1 hypothetical protein, similar to competence protein NP_374656.1 hypothetical protein, similar to DNA transport machinery protein comGB NP_374657.1 hypothetical protein, similar to late competence protein comGA NP_374664.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_374667.1 ferric uptake regulator homolog NP_374668.1 hypothetical protein, similar to ABC transporter NP_374669.1 hypothetical protein, similar to ABC transporter ATP-binding protein NP_374670.1 Probable endonuclease 4; Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues NP_374671.1 hypothetical protein, similar to ATP-dependent RNA helicase NP_374674.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium NP_374678.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_374679.1 DNA repair protein recO (Recombination protein O). NP_374680.1 GTP-binding protain Era homolog; Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome NP_374682.1 hypothetical protein, similar to diacylglycerol kinase NP_374684.1 phosphate starvation-induced protein phoH homolog NP_374688.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA NP_374690.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase NP_374691.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype NP_374692.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion NP_374693.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria NP_374694.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor NP_374696.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III NP_374698.1 binds to the ribosome on the universally-conserved alpha-sarcin loop NP_374699.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase NP_374700.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA NP_374701.1 hypothetical protein, similar to ComEC late competence protein 3 (comE operon) NP_374703.1 hypothetical protein, similar to late competence operon required for DNA binding and uptake comEA NP_374710.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis NP_374714.1 enterotoxin homolog NP_374715.1 hypothetical protein, similar to enterotoxin A precursor NP_374719.1 acetyl-CoA carboxylase (biotin carboxylase subunit), accC homolog NP_374720.1 hypothetical protein, similar to acetyl-CoA carboxylase (biotin carboxyl carrier subunit), accB homolog NP_374723.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus NP_374724.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor NP_374725.1 hypothetical protein, similar to protease NP_374726.1 hypothetical protein, similar to protease NP_374727.1 hypothetical protein, similar to caffeoyl-CoA O-methyltransferase NP_374729.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function NP_374731.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_374732.1 hypothetical protein, similar to deoxyribonuclease NP_374734.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs NP_374735.1 iron-sulfur cofactor synthesis protein homolog NP_374743.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes NP_374744.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG NP_374746.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine NP_374748.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis NP_374749.1 hypothetical protein, similar to single-strand DNA-specific exonuclease NP_374750.1 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF NP_374752.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) NP_374753.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step NP_374754.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration NP_374755.1 plays an essential role in ATP-dependent branch migration of the Holliday junction NP_374756.1 ACT domain-containing protein pheB. NP_374757.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication NP_374758.1 involved in the peptidyltransferase reaction during translation NP_374761.1 hypothetical protein, similar to cell shape determinant mreD NP_374762.1 hypothetical protein, similar to cell shape determinant mreC; in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall NP_374765.1 hypothetical protein, similar to transporter PAB2175 from Pyrococcus abyssi NP_374772.1 truncated hypothetical protein, similar to DNA repair protein NP_374773.1 hypothetical protein, similar to type IV prepilin peptidase NP_374775.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain NP_374779.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway NP_374780.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate NP_374782.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis NP_374784.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins NP_374785.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential NP_374786.1 binds and unfolds substrates as part of the ClpXP protease NP_374787.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer NP_374790.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit NP_374792.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits NP_374794.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) NP_374795.1 Primosomal protein that may act to load helicase DnaC during DNA replication NP_374799.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis NP_374800.1 hypothetical protein, similar to formamidopyrimidine-DNA glycosylase NP_374805.1 Converts isocitrate to alpha ketoglutarate NP_374806.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate NP_374809.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis NP_374810.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein NP_374811.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits NP_374812.1 malate dehydrogenase homolog NP_374817.1 catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins NP_374818.1 Xaa-Pro dipeptidase homolog NP_374821.1 acetate kinase homolog; AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA NP_374823.1 Probable thiol peroxidase; antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein NP_374825.1 Probable thiamine biosynthesis protein thiI; Required for the synthesis of the thiazole moiety NP_374826.1 hypothetical protein, similar to iron-sulfur cofactor synthesis protein nifZ NP_374827.1 Septation ring formation regulator ezrA; acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation NP_374829.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination NP_374831.1 hypothetical protein, similar to glycerophosphoryl diester phosphodiesterase NP_374833.1 hypothetical protein, similar to soluble hydrogenase 42 kD subunit NP_374834.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate NP_374837.1 hypothetical protein, similar to acylglycerol-3-phosphate O-acyltransfera homolog NP_374838.1 hypothetical protein, similar to serine proteinase Do, heat-shock protein htrA NP_374842.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate NP_374843.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA NP_374844.1 acetoin dehydrogenase homolog NP_374847.1 chorismate mutase homolog; catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate NP_374848.1 hypothetical protein, similar to smooth muscle caldesmon NP_374849.1 hypothetical protein, similar to general stress protein homolog NP_374850.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis NP_374851.1 DNA translocase stage III sporulation prot homolog NP_374852.1 phenylalanyl-tRNA synthetase (beta subunit) homolog NP_374854.1 thioredoxin homolog NP_374855.1 endo-1,4-beta-glucanase homolog NP_374858.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine NP_374861.1 Xaa-His dipeptidase homolog; divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases NP_374863.1 hypothetical protein, similar to 16S pseudouridylate synthase NP_374864.1 spore cortex protein homolog NP_374866.1 hypothetical protein, similar to FmtB protein NP_374868.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase NP_374869.1 multidrug resistance protein homolog NP_374873.1 lysophospholipase homolog NP_374874.1 proline dehydrohenase homolog NP_374875.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not NP_374877.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine NP_374880.1 arsenical resistance operon repressor homolog NP_374881.1 aesenical pump membrane protein homolog NP_374888.1 hypothetical protein, similar to transaldolase; similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity NP_374890.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling NP_374895.1 plant metabolite dehydrogenase homolog NP_374897.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase NP_374898.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP NP_374906.1 hypothetical protein, similar to latent nuclear antigen [Kaposi's sarcoma-associated herpesvirus] NP_374913.1 transposase homolog for IS232 [Insertion sequence IS1181] NP_374915.1 type I restriction enzyme EcoR124II M PROTEIN homolog [Pathogenicity island SaPIn3] NP_374939.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX NP_374940.1 ferrochelatase homolog; protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic NP_374941.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III NP_374943.1 hypothetical protein, similar to ABC transporter ecsB NP_374944.1 ABC transporter ecsA homolog NP_374948.1 peptidyl-prolyl cis/trans isomerase homolog NP_374949.1 catalyzes the exonucleic cleavage of mRNA yielding nucleioside 5'-phosphates NP_374955.1 two-component response regulator homolog NP_374956.1 two-component sensor histidine kinase homolog NP_374958.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle NP_374965.1 hypothetical protein, similar to glutamine-binding periplasmic protein NP_374966.1 hypothetical protein, similar to regulatory protein (pfoS/R) NP_374968.1 transcription regulator Fur family homolog NP_374969.1 hypothetical protein, similar to D-3-phosphoglycerate dehydrogenase NP_374971.1 converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate NP_374973.1 ABC transporter (ATP-binding protein) homolog NP_374975.1 hypothetical protein, similar to A/G-specific adenine glycosylase NP_374977.1 hypothetical protein, similar to teichoic acid transport protein tagG NP_374978.1 hypothetical protein, similar to teichoic acid translocation ATP-binding protein tagH NP_374980.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities NP_374981.1 Monofunctional glycosyltransferase; monofunctional; catalyzes the elongation of glycan strands in cell wall biosynthesis NP_374988.1 Low molecular weight protein-tyrosine-phosphatase ptpA NP_374990.1 hypothetical protein, similar to transporter NP_374995.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn NP_374998.1 hypothetical protein, similar to cobyric acid synthase CobQ NP_374999.1 hypothetical protein, similar to UDP-N-acetylmuramyl tripeptide synthetase homolog NP_375000.1 Ferritin NP_375001.1 hypothetical protein, similar to DNA polymerase III, alpha chain PolC type NP_375002.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function NP_375004.1 RNA methyltransferase homolog NP_375005.1 similar to YegS from E. coli NP_375006.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_375007.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_375008.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain NP_375013.1 PcrB-like protein; GGGP synthase; member of prenyltransferases that transfer isoprenoid groups to nonisoprenoid acceptors; functions in form GGGP from glycerol-1-phosphate (G-1-P) and geranylgeranyl pyrophosphate (GGPP); important in lipid metabolism and especially important as the ether linkages in archaea are different than those in bacteria; GGGP synthase lies at the branch point for membrane lipid biosynthesis; cytosolic; T acidophilum protein acts as a homodimer while M thermoautotrophicum protein has been reported to function as a pentamer NP_375015.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide NP_375019.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers NP_375020.1 nicotinate phosphoribosyltransferase homolog; catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate NP_375021.1 nitric-oxide synthase homolog NP_375022.1 hypothetical protein, similar to chorismate mutase/prephenate dehydratase (pheA) NP_375023.1 Sodium-dependent dicarboxylate transporter sdcS (Na(+)/dicarboxylate symporter). NP_375025.1 pyrazinamidase/nicotinamidase homolog NP_375026.1 catalyzes the hydrolysis of pyrophosphate to phosphate NP_375038.1 hypothetical protein, similar to ABC transporter, ATP-binding protein NP_375040.1 hypothetical protein, similar to ABC transporter, ATP-binding protein NP_375041.1 hypothetical protein, similar to transcription regulator, GntR family NP_375043.1 hypothetical protein, similar to aspartate transaminase NP_375050.1 secreted protein that specifically inhibits the activation of neutrophils and monocytes by binding to the formylated peptide receptor and the C5a receptor; blocks neutrophil migration towards the infection site and hinders the establishment of the initial defense against the infection NP_375055.1 holin homolog NP_375073.1 hypothetical protein, similar to scaffolding protein NP_375106.1 repressor homolog NP_375113.1 Uncharacterized leukocidin-like protein 1 precursor. NP_375114.1 Uncharacterized leukocidin-like protein 2 precursor. NP_375115.1 Probable succinyl-diaminopimelate desuccinylase; dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica NP_375116.1 hypothetical protein, similar to Na+-transporting ATP synthase NP_375119.1 hypothetical protein, similar to beta-lactamase NP_375121.1 hypothetical protein, similar to bacteriophage terminase small subunit NP_375134.1 hypothetical protein, similar to transcription regulator NP_375136.1 hypothetical protein, similar to integrase NP_375137.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth NP_375138.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring NP_375140.1 hypothetical protein, similar to SdrH NP_375143.1 Lyses erythrocytes and other mammalian cells NP_375148.1 hypothetical protein, similar to fructokinase NP_375154.1 modulates transcription in response to the NADH/NAD(+) redox state NP_375156.1 hypothetical protein, similar to DNA mismatch repair protein MutS NP_375157.1 Probable O-sialoglycoprotein endopeptidase; in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity NP_375158.1 hypothetical protein, similar to ribosomal-protein-alanine N-acetyltransfer NP_375159.1 hypothetical protein, similar to glycoprotein endopeptidase NP_375161.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis NP_375163.1 hypothetical protein, similar to acetolactate synthase small subunit; with IlvI catalyzes the formation of 2-acetolactate from pyruvate, this subunit subunit is required for full activity and valine sensitivity; also known as acetolactate synthase small NP_375164.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis NP_375165.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis NP_375166.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis NP_375167.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate NP_375168.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D NP_375169.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic NP_375172.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation; induced by heat shock, salt stress, oxidative stress, glucose limitation, oxygen limitation and entry into stationary phase NP_375173.1 binds to sigma-B preventing the formation of an RNA polymerase holoenzyme NP_375179.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids NP_375183.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex NP_375184.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions NP_375185.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions NP_375189.1 Probable DEAD-box ATP-dependent RNA helicase SA1885. NP_375191.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli NP_375192.1 hypothetical protein, similar to rod shape determining protein RodA NP_375196.1 Cardiolipin synthetase NP_375199.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate NP_375200.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP NP_375201.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine NP_375202.1 thiaminase-2 NP_375203.1 hypothetical protein, similar to SceD precursor NP_375204.1 hypothetical protein, similar to single strand DNA binding protein NP_375206.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP NP_375207.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_375209.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane NP_375210.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit NP_375211.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit NP_375212.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit NP_375213.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex NP_375214.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit B is part of the membrane proton channel NP_375215.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 NP_375216.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 NP_375219.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate NP_375220.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate NP_375222.1 Low molecular weight protein-tyrosine-phosphatase ptpB NP_375224.1 hypothetical protein, similar to protoporphyrinogen oxidase (hemK) NP_375225.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 NP_375226.1 catalyzes the formation of thymidine 5'-phosphate from thymidine NP_375227.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_375228.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes NP_375229.1 aldehyde dehydrogenase SA1924 NP_375231.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_375232.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; induced by anaerobic conditions in Bacillus subtilis NP_375234.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer NP_375235.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling NP_375236.1 hypothetical protein, similar to spermine/spermidine acetyltransferase blt NP_375237.1 Type II pantothenate kinase; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type II pantothenate kinases are not regulated by feedback inhibition by coenzyme A NP_375240.1 similar to amidase (HmrA) NP_375241.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 NP_375243.2 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway NP_375244.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate NP_375245.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate NP_375250.1 hypothetical protein, similar to mannnose-6 phospate isomelase pmi NP_375253.1 cation-efflux system membrane protein homolog NP_375262.1 hypothetical protein, similar to transposase for IS232 NP_375264.1 hypothetical protein, similar to transposase for IS232 NP_375265.1 hypothetical protein, similar to transposase for IS232 NP_375267.1 ; hypothetical protein, similar to transposase for IS232 NP_375268.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source NP_375271.1 hypothetical protein, similar to transcription antiterminator BglG family NP_375275.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate NP_375279.1 hypothetical protein, similar to ATP-binding Mrp-like protein NP_375280.1 hypothetical protein, similar to multidrug resistance protein NP_375282.1 hypothetical protein, similar to multidrug transporter NP_375283.1 hypothetical protein, similar to hemolysin III NP_375284.1 Probable uridylyltransferase SA1974 NP_375288.1 hypothetical protein, similar to ferrichrome ABC transporter (permease) NP_375289.1 hypothetical protein, similar to ferrichrome ABC transporter (permease) NP_375290.1 hypothetical protein, similar toferrichrome ABC transporter (binding prote) NP_375293.1 hypothetical protein, similar to transporter NP_375298.1 glycine betaine transporter opuD homolog NP_375299.1 Zinc-type alcohol dehydrogenase-like protein SA1988. NP_375300.1 hypothetical protein, similar to quinone oxidoreductase NP_375302.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside NP_375305.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources NP_375306.1 catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP NP_375307.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate NP_375308.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization NP_375310.1 Modulates the activities of several enzymes which are inactive in their acetylated form NP_375313.1 hypothetical protein, similar to oxidoreductase, aldo/keto reductase NP_375314.1 hypothetical protein, similar to transcription regulator MerR family NP_375318.1 hypothetical protein, similar to MHC class II analog NP_375319.1 hypothetical protein, similar to alpha-acetolactate decarboxylase NP_375320.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase NP_375322.1 hypothetical protein, similar to RNA-directed DNA polymerase from retron EC86 NP_375325.1 truncated IS232 IstB protein homolog NP_375326.1 SAS076 NP_375327.1 hypothetical protein, similar to transposase for IS232 NP_375328.1 truncated IS232 IstA protein homolog NP_375330.1 forms a direct contact with the tRNA during translation NP_375331.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit NP_375332.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability NP_375334.1 Cobalt import ATP-binding protein cbiO 1; with CbiNQ forms the ABC transporter for cobalt import; Staphylococcus has two adjacent copies of this gene NP_375335.1 Cobalt import ATP-binding protein cbiO 2; with CbiNQ forms the ABC transporter for cobalt import; Staphylococcus has two adjacent copies of this gene NP_375336.1 is a component of the macrolide binding site in the peptidyl transferase center NP_375337.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme NP_375338.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 NP_375339.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA NP_375340.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif NP_375341.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 NP_375342.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP NP_375343.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_375344.1 late assembly protein NP_375345.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 NP_375346.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance NP_375347.1 binds 5S rRNA along with protein L5 and L25 NP_375348.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance NP_375349.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit NP_375350.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif NP_375351.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 NP_375352.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel NP_375353.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase NP_375354.1 primary binding protein; helps mediate assembly; involved in translation fidelity NP_375355.1 one of the stabilizing components for the large ribosomal subunit NP_375356.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e NP_375357.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation NP_375358.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center NP_375359.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA NP_375360.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation NP_375361.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel NP_375362.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA NP_375363.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin NP_375364.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex NP_375367.1 decatenates replicating daughter chromosomes NP_375369.1 glucose uptake protein homolog NP_375374.1 hypothetical protein, similar to acriflavin resistance protein NP_375378.1 Uncharacterized HTH-type transcriptional regulator SA2060. NP_375382.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis NP_375387.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis NP_375393.1 FdhD-like protein; involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth NP_375395.1 hypothetical protein, similar to biotin biosynthesis protein NP_375396.1 hypothetical protein, similar to inosine-adenosine-guanosine-nucleoside hydrolase; IAG-nucleoside hydrolase NP_375397.1 hypothetical protein, similar to ferrichrome ABC transporter fhuD precursor NP_375398.1 hypothetical protein, similar to butyryl-CoA dehydrogenase NP_375400.1 hypothetical protein, similar to urea transporter NP_375401.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter NP_375402.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Staphylococcus saprophyticus plays a role in bladder invasiveness and may induce the formation of kidney and bladder stones due to the alkalization of urine NP_375403.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits NP_375404.1 involved in the assembly of the urease metallocenter; possible nickel donor NP_375408.1 staphylococcal accessory regulator A homolog NP_375411.1 hypothetical protein, similar to transcription regulator NP_375412.1 secretory antigen precursor SsaA homolog NP_375414.1 hypothetical protein, similar to Na+/H+ antiporter NP_375415.1 hypothetical protein, similar to D-octopine dehydrogenase NP_375417.1 hypothetical protein, similar to secretory antigen precursor SsaA NP_375418.1 2-hydroxyacid dehydrogenase SA2098; Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor NP_375419.1 hypothetical protein, similar to monooxygenase NP_375420.1 hypothetical protein, similar to autolysin E NP_375422.1 formate dehydrogenase homolog NP_375423.1 hypothetical protein, similar to lyt divergon expression attenuator LytR NP_375424.1 hypothetical protein, similar to suppressor protein suhB NP_375426.1 hypothetical protein, similar to protein of pXO2-46 NP_375428.1 hypothetical protein, similar to transcription regulator, RpiR family NP_375429.1 hypothetical protein, similar to transport protein NP_375433.1 hypothetical protein, similar to phosphoglycolate phosphatase NP_375434.1 hypothetical protein, similar to sodium-dependent transporter NP_375437.1 hypothetical protein, similar to transcriptional regulator NP_375439.1 hypothetical protein, similar to Na+/H+ antiporter NP_375441.1 hypothetical protein, similar to dehydrogenase NP_375442.1 hypothetical protein, similar to amino acid amidohydrolase NP_375443.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway NP_375444.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism NP_375445.1 hypothetical protein, similar to transcription regulator LysR family NP_375446.1 catalyzes resistance to fosfomycin by the addition of a thiol cofactor NP_375447.1 Formimidoylglutamase; catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate NP_375449.1 Ribose-5-phosphate isomerase A; catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway NP_375451.1 hypothetical protein, similar to aldose 1-epimerase NP_375454.1 hypothetical protein, similar to ABC transporter (ATP-binding protein) NP_375457.1 3-methyladenine DNA glycosylase NP_375458.1 hypothetical protein, similar to sodium/glutamate symporter NP_375459.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate NP_375460.1 hypothetical protein, similar to divalent cation transport NP_375463.1 hypothetical protein, similar to esterase NP_375465.1 hypothetical protein, similar to multidrug resistance protein NP_375467.1 hypothetical protein, similar to transcriptional regulator (TetR/AcrR family) NP_375471.1 hypothetical protein, similar to membrane protein NP_375472.1 hemin import ATP-binding protein hrtA NP_375474.1 hypothetical protein, similar to two component response regulator NP_375475.1 hypothetical protein, similar to two component histidine kinase sensor NP_375478.1 Probable malate:quinone oxidoreductase 1; malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate NP_375479.1 L-lactate permease lctP homolog NP_375481.1 Uncharacterized lipoprotein SA2158 precursor. NP_375482.1 hypothetical protein, similar to transcription repressor of sporulation, septation and degradation paiA NP_375484.1 hypothetical protein, similar to attachment to host cells and virulence NP_375485.1 hypothetical protein, similar to thioredoxin reductase NP_375487.1 hypothetical protein, similar to phage infection protein precursor NP_375488.1 hypothetical protein, similar to transcriptional regulator tetR-family NP_375489.1 hypothetical protein, similar to cationic transporter NP_375492.1 hypothetical protein, similar to transcription regulatory protein NP_375493.1 hypothetical protein, similar to general stress protein 26 NP_375497.1 HTH-type transcriptional regulator sarZ (Staphylococcal accessory regulator Z). NP_375498.1 hypothetical protein, similar to small heat shock protein NP_375501.1 hypothetical protein, similar to transcriptional regulator NP_375502.1 hypothetical protein, similar to response regulators of two-component regulatory NP_375503.1 hypothetical protein, similar to two component sensor histidine kinase NP_375506.1 hypothetical protein, similar to nitrate reductase delta chain NP_375512.1 hypothetical protein, similar to NirR NP_375514.1 hypothetical protein, similar to NirC NP_375517.1 hypothetical protein, similar to Zn-binding lipoprotein adcA NP_375523.1 hypothetical protein, similar to ABC transporter, ATP binding subunit NP_375524.1 hypothetical protein, similar to ABC transporter, permease NP_375525.1 hypothetical protein, similar to ABC transporter, periplasmic amino acid-binding protein NP_375526.1 hypothetical protein, similar to multidrug resistance protein NP_375527.1 phosphoglycerate mutase, pgm homolog; 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate NP_375533.1 hypothetical protein, similar to BioX protein NP_375534.1 catalyzes the formation of pimeloyl-CoA from pimelate and coenzyme A NP_375535.1 hypothetical protein, similar to 8-amino-7-oxononanoate synthase NP_375536.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine NP_375539.1 hypothetical protein, similar to ABC transporter, ATP-binding protein NP_375540.1 hypothetical protein, similar to lipoprotein inner membrane ABC-transporter NP_375545.1 hypothetical protein, similar to bicyclomycin resistance protein TcaB NP_375546.1 hypothetical protein, similar to transcriptional activator NP_375549.1 truncated hypothetical protein, similar to D-serine/D-alanine/glycine transporter NP_375550.1 truncated-SA NP_375551.1 hypothetical protein, similar to NA(+)/H(+) exchanger NP_375553.1 Protein flp (FmtA-like protein). NP_375554.1 hypothetical protein, similar to glucose epimerase NP_375555.1 hypothetical protein, similar to 2-dehydropantoate 2-reductase; ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis NP_375556.1 hypothetical protein, similar to integral membrane efflux protein NP_375562.1 hypothetical protein, similar to amino acid transporter NP_375563.1 hypothetical protein, similar to para-nitrobenzyl esterase chain A NP_375564.1 hypothetical protein, similar to chloramphenicol resistance protein NP_375566.1 hypothetical protein, similar to ABC transporter (ATP-binding protein NP_375567.1 hypothetical protein, similar to endo-1,4-beta-glucanase NP_375571.1 hypothetical protein, similar to glutamate synthase (ferredoxin) NP_375574.1 hypothetical protein, similar to antibiotic resistance protein NP_375582.1 hypothetical protein, similar to diaminopimelate epimerase NP_375584.1 hypothetical protein, similar to glucose 1-dehydrogenase NP_375585.1 hypothetical protein, similar to efflux pump NP_375590.1 Uncharacterized oxidoreductase SA2266 NP_375602.1 hypothetical protein, similar to mutator protein mutT NP_375603.1 Phosphoglucomutase NP_375609.1 surface protein SA2285 precursor. NP_375610.1 staphylococcal accessory regulator A homolog NP_375611.1 staphylococcal accessory regulator A homolog NP_375614.1 fibronectin-binding protein homolog NP_375615.1 fibronectin-binding protein homolog NP_375620.1 hypothetical protein, similar to transcriptional regulator, MerR family NP_375621.1 hypothetical protein, similar to GTP-pyrophosphokinase NP_375624.1 hypothetical protein, similar to glucarate transporter NP_375625.1 hypothetical protein, similar to alkaline phosphatase NP_375626.1 hypothetical protein, similar to ABC transporter NP_375627.1 hypothetical protein, similar to membrane spanning protein NP_375631.1 hypothetical protein, similar to ABC transporter (binding protein) NP_375632.1 hypothetical protein, similar to transcription regulator MarR family NP_375635.1 NAD(P)H nitroreductase SA2311 NP_375636.1 catalyzes the formation of pyruvate from lactate NP_375638.1 hypothetical protein, similar to ABC transporter (ATP-binding protein) NP_375641.1 hypothetical protein, similar to N-acetyltransferase NP_375642.1 hypothetical protein, similar to L-serine dehydratase NP_375643.1 hypothetical protein, similar to beta-subunit of L-serine dehydratas NP_375644.1 hypothetical protein, similar to regulatory protein pfoR NP_375648.1 hypothetical protein, similar to thioredoxin NP_375651.1 hypothetical protein, similar to pyruvate oxidase; catalyzes the formation of acetyl phosphate from pyruvate NP_375654.1 hypothetical protein, similar to transcription regulator NP_375656.1 hypothetical protein, similar to secretory antigen precursor SsaA NP_375662.1 ferrous iron transport protein B homolog NP_375664.1 hypothetical protein, similar to antibiotic transport-associated protein NP_375665.1 hypothetical protein, similar to transcriptional regulator tetR-family NP_375666.1 catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate NP_375667.1 acetyltransferase SA2342 NP_375670.1 hypothetical protein, similar to mercuric ion-binding protein NP_375671.1 hypothetical protein, similar to D-specific D-2-hydroxyacid dehydrogenase ddh homolog; catalyzes the formation of pyruvate from lactate NP_375672.1 hypothetical protein, similar to aspartate aminotransferase NP_375676.1 4,4'-diaponeurosporene oxidase NP_375678.1 Staphylococcal secretory antigen ssaA1 precursor. NP_375679.1 O-acetyltransferase oatA NP_375682.1 hypothetical protein, similar to regulatory protein (pfoS/R) NP_375683.1 hypothetical protein, similar to transcriptional regulator (TetR/AcrR family) NP_375690.1 HTH-type transcriptional regulator SA2364. NP_375691.1 hypothetical protein, similar to short chain oxidoreductase NP_375694.1 hypothetical protein, similar to cobalamin synthesis related protein CobW NP_375695.1 hypothetical protein, similar to ferrous iron transporter protein B NP_375701.1 hypothetical protein, similar to dihydroorotate dehydrogenase; catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors NP_375705.1 hypothetical protein, similar to transcriptional regulator tetR-family NP_375708.1 truncated hypothetical protein, similar to glutamyl-endopeptidase NP_375715.1 truncated hypothetical protein, similar to metalloproteinase mpr precursor NP_375716.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) NP_375717.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine NP_375718.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate NP_375719.1 hypothetical protein, similar to 2-dehydropantoate 2-reductase; catalyzes the formation of 2-dehydropantoate from (R)-pantoate NP_375720.1 hypothetical protein, similar to alpha-acetolactate decarboxylase NP_375722.1 hypothetical protein, similar to amino acid transporter NP_375723.1 hypothetical protein, similar to pyridoxal-phosphate dependent aminotransferase; catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate NP_375725.1 fructose-bisphosphate aldolase homolog; catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis NP_375726.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate NP_375731.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine NP_375735.1 hypothetical protein, similar to anaerobic ribonucleotide reductase activator protein NP_375736.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates NP_375737.1 hypothetical protein, similar to magnesium citrate secondary transporter NP_375738.1 hypothetical protein, similar to uroporphyrin-III C-methyltransferase; catalyzes the formation of siroheme from precorrin-2 NP_375740.1 hypothetical protein, similar to glutathione peroxidase NP_375741.1 hypothetical protein, similar to ABC transporter (permease) NP_375742.1 hypothetical protein, similar to ABC transporter (ATP-binding protein) NP_375743.1 hypothetical protein, similar to two-component sensor histidine kinase NP_375744.1 hypothetical protein, similar to two-component response regulator NP_375747.1 hypothetical protein, similar to transcriptional regulator NP_375748.1 hypothetical protein, similar to tributyrin esterase NP_375750.1 hypothetical protein, similar to transcription regulator Crp/Fnr family protein NP_375751.2 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP NP_375753.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway NP_375754.1 catalyzes the degradation of arginine to citruline and ammonia NP_375755.1 hypothetical protein, similar to arginine repressor NP_375759.1 hypothetical protein, similar to transcription antiterminator BglG family NP_375760.1 fructose phosphotransferase system enzyme fruA homolog NP_375762.1 hypothetical protein, similar to phage infection protein NP_375763.1 hypothetical protein, similar to autolysin precursor NP_375764.1 hypothetical protein, similar to N-Carbamoylsarcosine Amidohydrolase NP_375767.1 hypothetical protein, similar to lipopolysaccharide biosynthesis protein NP_375768.1 preprotein translocase secA homolog; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins NP_375772.1 hypothetical protein, similar to preprotein translocase secY; forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_375773.1 Serine-rich adhesin for platelets precursor (Staphylococcus aureus surface protein A). NP_375779.1 hypothetical protein, similar to peptide methionine sulfoxide reductase; this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; a fusion protein of this enzyme with MsrB provides protection against oxidative stress in Neisseria gonorrhoeae NP_375785.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein NP_375791.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis NP_375792.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase NP_375793.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-hosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide NP_375794.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide NP_375795.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis NP_375796.1 hypothetical protein, similar to histidinol-phosphate transaminase NP_375797.1 Histidinol dehydrogenase; catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer NP_375798.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ NP_375799.1 ATP phosphoribosyltransferase regulatory subunit; May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine NP_375803.1 ABC transporter ATP-binding protein SA2476 NP_375809.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline NP_375813.1 2-oxoglutarate/malate translocator homolog NP_375814.1 hypothetical protein, similar to rarD protein NP_375816.1 hypothetical protein, similar to high-affinity nickel-transport protein NP_375817.1 hypothetical protein, similar to N-hydroxyarylamine O-acetyltransferase NP_375819.1 hypothetical protein, similar to ABC transporter NP_375820.1 hypothetical protein, similar to ABC transporter (permease) NP_375827.1 hypothetical protein, similar to DNA-binding protein Spo0J-like homolog NP_375828.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA NP_375829.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs NP_375830.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE NP_375831.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates NP_375832.1 in Escherichia coli transcription of this gene is enhanced by polyamines NP_395537.1 putative replication initiation protein Rep [Staphylococcus aureus] NP_395545.1 hypothetical protein, similar to MarR family NP_395548.1 (REGULATORY PROTEIN BLAI) NP_395549.1 Staphylococcus aureus transposon Tn552. NP_395550.1 probable transposase - Staphylococcus aureus transposon Tn552 NP_395551.1 Staphylococcus aureus plasmid pSK1. NP_395552.1 Staphylococcus aureus plasmid pI258 resistance operon repressor - Staphylococcus aureus plasmid pI258 NP_395554.1 catalyzes the reduction of arsenate to arsenite; also can dephosphorylate tyrosine phosphorylated proteins, aryl phosphates, and acyl phosphates NP_395558.1 hypothetical protein, similar to ABC transporter, ATP-binding protein NP_395559.1 (plasmid recombination) [Plasmid pT181] NP_395560.1 (plasmid recombination) [Plasmid pT181] NP_395561.1 (plasmid recombination) [Plasmid pT181] NP_395567.1 hypothetical proetin