-- dump date   	20140620_074535
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
158879000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
158879000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
158879000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879000004	Walker A motif; other site
158879000005	ATP binding site [chemical binding]; other site
158879000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
158879000007	Walker B motif; other site
158879000008	arginine finger; other site
158879000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
158879000010	DnaA box-binding interface [nucleotide binding]; other site
158879000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
158879000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
158879000013	putative DNA binding surface [nucleotide binding]; other site
158879000014	dimer interface [polypeptide binding]; other site
158879000015	beta-clamp/clamp loader binding surface; other site
158879000016	beta-clamp/translesion DNA polymerase binding surface; other site
158879000017	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
158879000018	recF protein; Region: recf; TIGR00611
158879000019	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
158879000020	Walker A/P-loop; other site
158879000021	ATP binding site [chemical binding]; other site
158879000022	Q-loop/lid; other site
158879000023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
158879000024	ABC transporter signature motif; other site
158879000025	Walker B; other site
158879000026	D-loop; other site
158879000027	H-loop/switch region; other site
158879000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
158879000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879000030	Mg2+ binding site [ion binding]; other site
158879000031	G-X-G motif; other site
158879000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
158879000033	anchoring element; other site
158879000034	dimer interface [polypeptide binding]; other site
158879000035	ATP binding site [chemical binding]; other site
158879000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
158879000037	active site
158879000038	putative metal-binding site [ion binding]; other site
158879000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
158879000040	DNA gyrase subunit A; Validated; Region: PRK05560
158879000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
158879000042	CAP-like domain; other site
158879000043	active site
158879000044	primary dimer interface [polypeptide binding]; other site
158879000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
158879000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
158879000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
158879000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
158879000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
158879000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
158879000051	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
158879000052	putative substrate binding site [chemical binding]; other site
158879000053	putative ATP binding site [chemical binding]; other site
158879000054	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
158879000055	active sites [active]
158879000056	tetramer interface [polypeptide binding]; other site
158879000057	seryl-tRNA synthetase; Provisional; Region: PRK05431
158879000058	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
158879000059	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
158879000060	dimer interface [polypeptide binding]; other site
158879000061	active site
158879000062	motif 1; other site
158879000063	motif 2; other site
158879000064	motif 3; other site
158879000065	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
158879000066	Predicted membrane protein [Function unknown]; Region: COG4392
158879000067	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
158879000068	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
158879000069	Predicted membrane protein [Function unknown]; Region: COG4241
158879000070	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
158879000071	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
158879000072	DHH family; Region: DHH; pfam01368
158879000073	DHHA1 domain; Region: DHHA1; pfam02272
158879000074	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
158879000075	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
158879000076	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
158879000077	replicative DNA helicase; Region: DnaB; TIGR00665
158879000078	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
158879000079	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
158879000080	Walker A motif; other site
158879000081	ATP binding site [chemical binding]; other site
158879000082	Walker B motif; other site
158879000083	DNA binding loops [nucleotide binding]
158879000084	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
158879000085	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
158879000086	GDP-binding site [chemical binding]; other site
158879000087	ACT binding site; other site
158879000088	IMP binding site; other site
158879000089	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
158879000090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879000091	active site
158879000092	phosphorylation site [posttranslational modification]
158879000093	intermolecular recognition site; other site
158879000094	dimerization interface [polypeptide binding]; other site
158879000095	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
158879000096	DNA binding site [nucleotide binding]
158879000097	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
158879000098	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
158879000099	dimerization interface [polypeptide binding]; other site
158879000100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
158879000101	putative active site [active]
158879000102	heme pocket [chemical binding]; other site
158879000103	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
158879000104	dimer interface [polypeptide binding]; other site
158879000105	phosphorylation site [posttranslational modification]
158879000106	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879000107	ATP binding site [chemical binding]; other site
158879000108	Mg2+ binding site [ion binding]; other site
158879000109	G-X-G motif; other site
158879000110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
158879000111	YycH protein; Region: YycH; pfam07435
158879000112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853
158879000113	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
158879000114	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
158879000115	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
158879000116	putative active site [active]
158879000117	putative metal binding site [ion binding]; other site
158879000118	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
158879000119	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
158879000120	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
158879000121	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
158879000122	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
158879000123	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
158879000124	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
158879000125	Integrase core domain; Region: rve; pfam00665
158879000126	Replication protein; Region: Rep_1; cl02412
158879000127	Plasmid rolling circle replication initiator protein and truncated derivatives [DNA replication, recombination, and repair]; Region: COG5655
158879000128	similar to hypothetical protein
158879000129	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
158879000130	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
158879000131	dimer interface [polypeptide binding]; other site
158879000132	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
158879000133	ligand binding site [chemical binding]; other site
158879000134	Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cd05397
158879000135	metal binding triad [ion binding]; metal-binding site
158879000136	KNTase C-terminal domain; Region: KNTase_C; pfam07827
158879000137	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
158879000138	Integrase core domain; Region: rve; pfam00665
158879000139	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
158879000140	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
158879000141	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
158879000142	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
158879000143	putative active site [active]
158879000144	catalytic site [active]
158879000145	putative metal binding site [ion binding]; other site
158879000146	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
158879000147	putative active site [active]
158879000148	putative catalytic site [active]
158879000149	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
158879000150	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
158879000151	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
158879000152	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
158879000153	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
158879000154	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
158879000155	Predicted transcriptional regulator [Transcription]; Region: COG3682
158879000156	MarR family; Region: MarR_2; pfam12802
158879000157	Transcriptional regulators [Transcription]; Region: MarR; COG1846
158879000158	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
158879000159	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
158879000160	nucleotide binding site [chemical binding]; other site
158879000161	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
158879000162	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
158879000163	active site residue [active]
158879000164	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
158879000165	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
158879000166	active site residue [active]
158879000167	SirA_RHOD_Pry_redox.    SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420
158879000168	CPxP  motif; other site
158879000169	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
158879000170	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
158879000171	putative homodimer interface [polypeptide binding]; other site
158879000172	putative homotetramer interface [polypeptide binding]; other site
158879000173	putative metal binding site [ion binding]; other site
158879000174	putative homodimer-homodimer interface [polypeptide binding]; other site
158879000175	putative allosteric switch controlling residues; other site
158879000176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879000177	S-adenosylmethionine binding site [chemical binding]; other site
158879000178	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
158879000179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879000180	S-adenosylmethionine binding site [chemical binding]; other site
158879000181	aminoglycoside resistance protein; Provisional; Region: PRK13746
158879000182	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
158879000183	active site
158879000184	NTP binding site [chemical binding]; other site
158879000185	metal binding triad [ion binding]; metal-binding site
158879000186	antibiotic binding site [chemical binding]; other site
158879000187	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
158879000188	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
158879000189	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
158879000190	Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195
158879000191	Int/Topo IB signature motif; other site
158879000192	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
158879000193	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
158879000194	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
158879000195	Int/Topo IB signature motif; other site
158879000196	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
158879000197	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
158879000198	MPN+ (JAMM) motif; other site
158879000199	Zinc-binding site [ion binding]; other site
158879000200	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4333
158879000201	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
158879000202	Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106
158879000203	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
158879000204	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
158879000205	catalytic residues [active]
158879000206	catalytic nucleophile [active]
158879000207	Presynaptic Site I dimer interface [polypeptide binding]; other site
158879000208	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
158879000209	Synaptic Flat tetramer interface [polypeptide binding]; other site
158879000210	Synaptic Site I dimer interface [polypeptide binding]; other site
158879000211	DNA binding site [nucleotide binding]
158879000212	Recombinase; Region: Recombinase; pfam07508
158879000213	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
158879000214	Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262
158879000215	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
158879000216	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
158879000217	catalytic residues [active]
158879000218	catalytic nucleophile [active]
158879000219	Recombinase; Region: Recombinase; pfam07508
158879000220	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
158879000221	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
158879000222	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
158879000223	Integrase core domain; Region: rve; pfam00665
158879000224	Integrase core domain; Region: rve_3; cl15866
158879000225	HTH-like domain; Region: HTH_21; pfam13276
158879000226	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
158879000227	Homeodomain-like domain; Region: HTH_23; cl17451
158879000228	Predicted membrane protein [Function unknown]; Region: COG1288
158879000229	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
158879000230	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879000231	active site
158879000232	phosphorylation site [posttranslational modification]
158879000233	intermolecular recognition site; other site
158879000234	dimerization interface [polypeptide binding]; other site
158879000235	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
158879000236	DNA binding site [nucleotide binding]
158879000237	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
158879000238	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
158879000239	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
158879000240	Ligand Binding Site [chemical binding]; other site
158879000241	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
158879000242	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
158879000243	dimer interface [polypeptide binding]; other site
158879000244	phosphorylation site [posttranslational modification]
158879000245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879000246	ATP binding site [chemical binding]; other site
158879000247	Mg2+ binding site [ion binding]; other site
158879000248	G-X-G motif; other site
158879000249	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060
158879000250	High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216
158879000251	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
158879000252	Soluble P-type ATPase [General function prediction only]; Region: COG4087
158879000253	K+-transporting ATPase, c chain; Region: KdpC; cl00944
158879000254	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
158879000255	Protein kinase domain; Region: Pkinase; pfam00069
158879000256	Catalytic domain of Protein Kinases; Region: PKc; cd00180
158879000257	active site
158879000258	ATP binding site [chemical binding]; other site
158879000259	substrate binding site [chemical binding]; other site
158879000260	activation loop (A-loop); other site
158879000261	sporadically distributed protein, TIGR04141 family; Region: TIGR04141
158879000262	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
158879000263	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
158879000264	phosphate binding site [ion binding]; other site
158879000265	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
158879000266	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
158879000267	putative homodimer interface [polypeptide binding]; other site
158879000268	putative homotetramer interface [polypeptide binding]; other site
158879000269	putative metal binding site [ion binding]; other site
158879000270	putative homodimer-homodimer interface [polypeptide binding]; other site
158879000271	putative allosteric switch controlling residues; other site
158879000272	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
158879000273	active site residue [active]
158879000274	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
158879000275	CPxP  motif; other site
158879000276	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
158879000277	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
158879000278	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
158879000279	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
158879000280	active site residue [active]
158879000281	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
158879000282	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
158879000283	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
158879000284	FMN binding site [chemical binding]; other site
158879000285	active site
158879000286	catalytic residues [active]
158879000287	substrate binding site [chemical binding]; other site
158879000288	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
158879000289	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
158879000290	Part of AAA domain; Region: AAA_19; pfam13245
158879000291	AAA domain; Region: AAA_12; pfam13087
158879000292	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
158879000293	active site
158879000294	catalytic site [active]
158879000295	putative metal binding site [ion binding]; other site
158879000296	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879000297	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879000298	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879000299	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879000300	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879000301	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
158879000302	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
158879000303	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
158879000304	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
158879000305	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
158879000306	metal binding site [ion binding]; metal-binding site
158879000307	dimer interface [polypeptide binding]; other site
158879000308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879000309	Major Facilitator Superfamily; Region: MFS_1; pfam07690
158879000310	putative substrate translocation pore; other site
158879000311	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879000312	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
158879000313	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
158879000314	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
158879000315	PhoU domain; Region: PhoU; pfam01895
158879000316	Myosin-crossreactive antigen [Function unknown]; Region: COG4716
158879000317	EamA-like transporter family; Region: EamA; pfam00892
158879000318	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
158879000319	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
158879000320	DNA-binding site [nucleotide binding]; DNA binding site
158879000321	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
158879000322	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879000323	homodimer interface [polypeptide binding]; other site
158879000324	catalytic residue [active]
158879000325	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
158879000326	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
158879000327	L-lactate permease; Region: Lactate_perm; cl00701
158879000328	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
158879000329	B domain; Region: B; pfam02216
158879000330	B domain; Region: B; pfam02216
158879000331	B domain; Region: B; pfam02216
158879000332	B domain; Region: B; pfam02216
158879000333	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
158879000334	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
158879000335	Transcriptional regulators [Transcription]; Region: MarR; COG1846
158879000336	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
158879000337	Transcriptional regulators [Transcription]; Region: MarR; COG1846
158879000338	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
158879000339	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
158879000340	ABC-ATPase subunit  interface; other site
158879000341	dimer interface [polypeptide binding]; other site
158879000342	putative PBP binding regions; other site
158879000343	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
158879000344	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
158879000345	ABC-ATPase subunit  interface; other site
158879000346	dimer interface [polypeptide binding]; other site
158879000347	putative PBP binding regions; other site
158879000348	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
158879000349	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
158879000350	siderophore binding site; other site
158879000351	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
158879000352	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
158879000353	dimer interface [polypeptide binding]; other site
158879000354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879000355	catalytic residue [active]
158879000356	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
158879000357	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
158879000358	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
158879000359	IucA / IucC family; Region: IucA_IucC; pfam04183
158879000360	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
158879000361	drug efflux system protein MdtG; Provisional; Region: PRK09874
158879000362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879000363	putative substrate translocation pore; other site
158879000364	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
158879000365	IucA / IucC family; Region: IucA_IucC; pfam04183
158879000366	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
158879000367	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
158879000368	IucA / IucC family; Region: IucA_IucC; pfam04183
158879000369	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
158879000370	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
158879000371	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
158879000372	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
158879000373	dimer interface [polypeptide binding]; other site
158879000374	active site
158879000375	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
158879000376	catalytic residues [active]
158879000377	substrate binding site [chemical binding]; other site
158879000378	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
158879000379	ParB-like nuclease domain; Region: ParBc; pfam02195
158879000380	acetoin reductase; Validated; Region: PRK08643
158879000381	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
158879000382	NAD binding site [chemical binding]; other site
158879000383	homotetramer interface [polypeptide binding]; other site
158879000384	homodimer interface [polypeptide binding]; other site
158879000385	active site
158879000386	substrate binding site [chemical binding]; other site
158879000387	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
158879000388	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
158879000389	NAD(P) binding site [chemical binding]; other site
158879000390	active site
158879000391	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
158879000392	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
158879000393	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
158879000394	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
158879000395	putative ADP-binding pocket [chemical binding]; other site
158879000396	O-Antigen Polymerase; Region: Wzy_C; cl04850
158879000397	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
158879000398	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
158879000399	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
158879000400	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
158879000401	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
158879000402	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
158879000403	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
158879000404	DNA-binding site [nucleotide binding]; DNA binding site
158879000405	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
158879000406	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
158879000407	Major Facilitator Superfamily; Region: MFS_1; pfam07690
158879000408	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
158879000409	intersubunit interface [polypeptide binding]; other site
158879000410	active site
158879000411	catalytic residue [active]
158879000412	phosphopentomutase; Provisional; Region: PRK05362
158879000413	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
158879000414	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
158879000415	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879000416	dimer interface [polypeptide binding]; other site
158879000417	conserved gate region; other site
158879000418	putative PBP binding loops; other site
158879000419	ABC-ATPase subunit interface; other site
158879000420	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
158879000421	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879000422	dimer interface [polypeptide binding]; other site
158879000423	conserved gate region; other site
158879000424	ABC-ATPase subunit interface; other site
158879000425	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
158879000426	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
158879000427	Walker A/P-loop; other site
158879000428	ATP binding site [chemical binding]; other site
158879000429	Q-loop/lid; other site
158879000430	ABC transporter signature motif; other site
158879000431	Walker B; other site
158879000432	D-loop; other site
158879000433	H-loop/switch region; other site
158879000434	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
158879000435	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
158879000436	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
158879000437	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
158879000438	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
158879000439	active site
158879000440	metal binding site [ion binding]; metal-binding site
158879000441	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
158879000442	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
158879000443	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
158879000444	non-specific DNA binding site [nucleotide binding]; other site
158879000445	salt bridge; other site
158879000446	sequence-specific DNA binding site [nucleotide binding]; other site
158879000447	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
158879000448	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
158879000449	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
158879000450	putative catalytic cysteine [active]
158879000451	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
158879000452	putative active site [active]
158879000453	metal binding site [ion binding]; metal-binding site
158879000454	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
158879000455	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
158879000456	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
158879000457	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
158879000458	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
158879000459	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
158879000460	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
158879000461	NAD(P) binding site [chemical binding]; other site
158879000462	homodimer interface [polypeptide binding]; other site
158879000463	substrate binding site [chemical binding]; other site
158879000464	active site
158879000465	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
158879000466	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
158879000467	NAD(P) binding site [chemical binding]; other site
158879000468	homodimer interface [polypeptide binding]; other site
158879000469	substrate binding site [chemical binding]; other site
158879000470	active site
158879000471	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
158879000472	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
158879000473	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
158879000474	putative NAD(P) binding site [chemical binding]; other site
158879000475	active site
158879000476	putative substrate binding site [chemical binding]; other site
158879000477	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
158879000478	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
158879000479	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
158879000480	active site
158879000481	homodimer interface [polypeptide binding]; other site
158879000482	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
158879000483	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
158879000484	trimer interface [polypeptide binding]; other site
158879000485	active site
158879000486	substrate binding site [chemical binding]; other site
158879000487	CoA binding site [chemical binding]; other site
158879000488	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
158879000489	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
158879000490	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
158879000491	O-Antigen ligase; Region: Wzy_C; pfam04932
158879000492	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
158879000493	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
158879000494	Bacterial sugar transferase; Region: Bac_transf; pfam02397
158879000495	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
158879000496	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
158879000497	putative NAD(P) binding site [chemical binding]; other site
158879000498	active site
158879000499	putative substrate binding site [chemical binding]; other site
158879000500	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
158879000501	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
158879000502	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
158879000503	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
158879000504	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
158879000505	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
158879000506	active site
158879000507	homodimer interface [polypeptide binding]; other site
158879000508	heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313
158879000509	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
158879000510	Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117
158879000511	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
158879000512	NAD(P) binding site [chemical binding]; other site
158879000513	catalytic residues [active]
158879000514	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
158879000515	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
158879000516	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
158879000517	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
158879000518	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
158879000519	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
158879000520	Walker A/P-loop; other site
158879000521	ATP binding site [chemical binding]; other site
158879000522	Q-loop/lid; other site
158879000523	ABC transporter signature motif; other site
158879000524	Walker B; other site
158879000525	D-loop; other site
158879000526	H-loop/switch region; other site
158879000527	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
158879000528	NMT1-like family; Region: NMT1_2; pfam13379
158879000529	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
158879000530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
158879000531	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
158879000532	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
158879000533	active site
158879000534	Uncharacterized conserved protein [Function unknown]; Region: COG5609
158879000535	formate dehydrogenase; Provisional; Region: PRK07574
158879000536	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
158879000537	dimerization interface [polypeptide binding]; other site
158879000538	ligand binding site [chemical binding]; other site
158879000539	NAD binding site [chemical binding]; other site
158879000540	catalytic site [active]
158879000541	putative transporter; Provisional; Region: PRK10054
158879000542	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
158879000543	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
158879000544	acyl-activating enzyme (AAE) consensus motif; other site
158879000545	AMP binding site [chemical binding]; other site
158879000546	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
158879000547	Condensation domain; Region: Condensation; pfam00668
158879000548	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
158879000549	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
158879000550	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
158879000551	acyl-activating enzyme (AAE) consensus motif; other site
158879000552	AMP binding site [chemical binding]; other site
158879000553	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
158879000554	thioester reductase domain; Region: Thioester-redct; TIGR01746
158879000555	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
158879000556	NAD(P) binding site [chemical binding]; other site
158879000557	active site
158879000558	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
158879000559	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
158879000560	Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477
158879000561	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
158879000562	nucleotide binding site [chemical binding]; other site
158879000563	N-acetyl-L-glutamate binding site [chemical binding]; other site
158879000564	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
158879000565	heterotetramer interface [polypeptide binding]; other site
158879000566	active site pocket [active]
158879000567	cleavage site
158879000568	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
158879000569	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
158879000570	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
158879000571	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
158879000572	inhibitor-cofactor binding pocket; inhibition site
158879000573	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879000574	catalytic residue [active]
158879000575	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
158879000576	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
158879000577	Isochorismatase family; Region: Isochorismatase; pfam00857
158879000578	catalytic triad [active]
158879000579	conserved cis-peptide bond; other site
158879000580	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
158879000581	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
158879000582	dimer interface [polypeptide binding]; other site
158879000583	PYR/PP interface [polypeptide binding]; other site
158879000584	TPP binding site [chemical binding]; other site
158879000585	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
158879000586	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
158879000587	TPP-binding site [chemical binding]; other site
158879000588	dimer interface [polypeptide binding]; other site
158879000589	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
158879000590	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
158879000591	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
158879000592	active site turn [active]
158879000593	phosphorylation site [posttranslational modification]
158879000594	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
158879000595	HPr interaction site; other site
158879000596	glycerol kinase (GK) interaction site [polypeptide binding]; other site
158879000597	active site
158879000598	phosphorylation site [posttranslational modification]
158879000599	Uncharacterized conserved protein [Function unknown]; Region: COG3589
158879000600	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
158879000601	Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103
158879000602	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
158879000603	putative active site [active]
158879000604	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
158879000605	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
158879000606	active site turn [active]
158879000607	phosphorylation site [posttranslational modification]
158879000608	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
158879000609	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
158879000610	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
158879000611	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
158879000612	putative active site [active]
158879000613	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
158879000614	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
158879000615	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
158879000616	ATP binding site [chemical binding]; other site
158879000617	putative Mg++ binding site [ion binding]; other site
158879000618	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
158879000619	HlyD family secretion protein; Region: HlyD_3; pfam13437
158879000620	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
158879000621	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
158879000622	Walker A/P-loop; other site
158879000623	ATP binding site [chemical binding]; other site
158879000624	Q-loop/lid; other site
158879000625	ABC transporter signature motif; other site
158879000626	Walker B; other site
158879000627	D-loop; other site
158879000628	H-loop/switch region; other site
158879000629	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
158879000630	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
158879000631	FtsX-like permease family; Region: FtsX; pfam02687
158879000632	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
158879000633	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
158879000634	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
158879000635	Walker A/P-loop; other site
158879000636	ATP binding site [chemical binding]; other site
158879000637	Q-loop/lid; other site
158879000638	ABC transporter signature motif; other site
158879000639	Walker B; other site
158879000640	D-loop; other site
158879000641	H-loop/switch region; other site
158879000642	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
158879000643	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
158879000644	Walker A/P-loop; other site
158879000645	ATP binding site [chemical binding]; other site
158879000646	Q-loop/lid; other site
158879000647	ABC transporter signature motif; other site
158879000648	Walker B; other site
158879000649	D-loop; other site
158879000650	H-loop/switch region; other site
158879000651	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
158879000652	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
158879000653	Walker A/P-loop; other site
158879000654	ATP binding site [chemical binding]; other site
158879000655	Q-loop/lid; other site
158879000656	ABC transporter signature motif; other site
158879000657	Walker B; other site
158879000658	D-loop; other site
158879000659	H-loop/switch region; other site
158879000660	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
158879000661	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879000662	dimer interface [polypeptide binding]; other site
158879000663	conserved gate region; other site
158879000664	putative PBP binding loops; other site
158879000665	ABC-ATPase subunit interface; other site
158879000666	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
158879000667	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879000668	dimer interface [polypeptide binding]; other site
158879000669	conserved gate region; other site
158879000670	ABC-ATPase subunit interface; other site
158879000671	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
158879000672	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
158879000673	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
158879000674	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
158879000675	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
158879000676	Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742
158879000677	azoreductase; Reviewed; Region: PRK00170
158879000678	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
158879000679	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
158879000680	Peptidase family M23; Region: Peptidase_M23; pfam01551
158879000681	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
158879000682	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
158879000683	Walker A/P-loop; other site
158879000684	ATP binding site [chemical binding]; other site
158879000685	Q-loop/lid; other site
158879000686	ABC transporter signature motif; other site
158879000687	Walker B; other site
158879000688	D-loop; other site
158879000689	H-loop/switch region; other site
158879000690	TOBE domain; Region: TOBE; pfam03459
158879000691	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
158879000692	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
158879000693	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879000694	dimer interface [polypeptide binding]; other site
158879000695	conserved gate region; other site
158879000696	ABC-ATPase subunit interface; other site
158879000697	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
158879000698	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879000699	dimer interface [polypeptide binding]; other site
158879000700	conserved gate region; other site
158879000701	putative PBP binding loops; other site
158879000702	ABC-ATPase subunit interface; other site
158879000703	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
158879000704	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
158879000705	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
158879000706	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
158879000707	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
158879000708	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
158879000709	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
158879000710	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
158879000711	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
158879000712	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
158879000713	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879000714	putative substrate translocation pore; other site
158879000715	Response regulator receiver domain; Region: Response_reg; pfam00072
158879000716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879000717	active site
158879000718	phosphorylation site [posttranslational modification]
158879000719	intermolecular recognition site; other site
158879000720	dimerization interface [polypeptide binding]; other site
158879000721	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
158879000722	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
158879000723	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
158879000724	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
158879000725	Histidine kinase; Region: His_kinase; pfam06580
158879000726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879000727	ATP binding site [chemical binding]; other site
158879000728	Mg2+ binding site [ion binding]; other site
158879000729	G-X-G motif; other site
158879000730	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
158879000731	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
158879000732	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
158879000733	Pyruvate formate lyase 1; Region: PFL1; cd01678
158879000734	coenzyme A binding site [chemical binding]; other site
158879000735	active site
158879000736	catalytic residues [active]
158879000737	glycine loop; other site
158879000738	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
158879000739	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
158879000740	FeS/SAM binding site; other site
158879000741	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
158879000742	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
158879000743	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
158879000744	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
158879000745	putative active site [active]
158879000746	catalytic site [active]
158879000747	putative metal binding site [ion binding]; other site
158879000748	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
158879000749	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
158879000750	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
158879000751	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
158879000752	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
158879000753	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
158879000754	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
158879000755	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
158879000756	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
158879000757	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
158879000758	dimer interface [polypeptide binding]; other site
158879000759	active site
158879000760	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
158879000761	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
158879000762	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
158879000763	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
158879000764	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
158879000765	substrate binding site [chemical binding]; other site
158879000766	oxyanion hole (OAH) forming residues; other site
158879000767	trimer interface [polypeptide binding]; other site
158879000768	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
158879000769	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
158879000770	active site
158879000771	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
158879000772	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
158879000773	acyl-activating enzyme (AAE) consensus motif; other site
158879000774	AMP binding site [chemical binding]; other site
158879000775	active site
158879000776	CoA binding site [chemical binding]; other site
158879000777	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
158879000778	Coenzyme A transferase; Region: CoA_trans; smart00882
158879000779	Coenzyme A transferase; Region: CoA_trans; cl17247
158879000780	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
158879000781	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
158879000782	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
158879000783	Uncharacterized conserved protein [Function unknown]; Region: COG3189
158879000784	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
158879000785	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
158879000786	heme-binding site [chemical binding]; other site
158879000787	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
158879000788	FAD binding pocket [chemical binding]; other site
158879000789	FAD binding motif [chemical binding]; other site
158879000790	phosphate binding motif [ion binding]; other site
158879000791	beta-alpha-beta structure motif; other site
158879000792	NAD binding pocket [chemical binding]; other site
158879000793	Heme binding  pocket [chemical binding]; other site
158879000794	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
158879000795	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
158879000796	tetramer (dimer of dimers) interface [polypeptide binding]; other site
158879000797	NAD binding site [chemical binding]; other site
158879000798	dimer interface [polypeptide binding]; other site
158879000799	substrate binding site [chemical binding]; other site
158879000800	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
158879000801	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
158879000802	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
158879000803	active site turn [active]
158879000804	phosphorylation site [posttranslational modification]
158879000805	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
158879000806	active site
158879000807	tetramer interface [polypeptide binding]; other site
158879000808	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
158879000809	Mga helix-turn-helix domain; Region: Mga; pfam05043
158879000810	PRD domain; Region: PRD; pfam00874
158879000811	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
158879000812	active site
158879000813	P-loop; other site
158879000814	phosphorylation site [posttranslational modification]
158879000815	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
158879000816	active site
158879000817	phosphorylation site [posttranslational modification]
158879000818	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
158879000819	active site
158879000820	phosphorylation site [posttranslational modification]
158879000821	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
158879000822	active site
158879000823	P-loop; other site
158879000824	phosphorylation site [posttranslational modification]
158879000825	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
158879000826	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
158879000827	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
158879000828	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
158879000829	putative NAD(P) binding site [chemical binding]; other site
158879000830	catalytic Zn binding site [ion binding]; other site
158879000831	structural Zn binding site [ion binding]; other site
158879000832	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
158879000833	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
158879000834	putative NAD(P) binding site [chemical binding]; other site
158879000835	catalytic Zn binding site [ion binding]; other site
158879000836	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
158879000837	substrate binding site; other site
158879000838	dimer interface; other site
158879000839	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
158879000840	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
158879000841	putative NAD(P) binding site [chemical binding]; other site
158879000842	putative catalytic Zn binding site [ion binding]; other site
158879000843	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
158879000844	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
158879000845	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
158879000846	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
158879000847	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
158879000848	substrate binding site; other site
158879000849	dimer interface; other site
158879000850	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
158879000851	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
158879000852	putative NAD(P) binding site [chemical binding]; other site
158879000853	putative catalytic Zn binding site [ion binding]; other site
158879000854	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
158879000855	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
158879000856	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
158879000857	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
158879000858	active site
158879000859	cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276
158879000860	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
158879000861	Hemerythrin-like domain; Region: Hr-like; cd12108
158879000862	Fe binding site [ion binding]; other site
158879000863	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
158879000864	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
158879000865	Histidine kinase; Region: His_kinase; pfam06580
158879000866	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879000867	Mg2+ binding site [ion binding]; other site
158879000868	G-X-G motif; other site
158879000869	two-component response regulator; Provisional; Region: PRK14084
158879000870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879000871	active site
158879000872	phosphorylation site [posttranslational modification]
158879000873	intermolecular recognition site; other site
158879000874	dimerization interface [polypeptide binding]; other site
158879000875	LytTr DNA-binding domain; Region: LytTR; pfam04397
158879000876	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
158879000877	antiholin-like protein LrgB; Provisional; Region: PRK04288
158879000878	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
158879000879	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
158879000880	DNA-binding site [nucleotide binding]; DNA binding site
158879000881	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
158879000882	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
158879000883	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
158879000884	HPr interaction site; other site
158879000885	glycerol kinase (GK) interaction site [polypeptide binding]; other site
158879000886	active site
158879000887	phosphorylation site [posttranslational modification]
158879000888	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
158879000889	beta-galactosidase; Region: BGL; TIGR03356
158879000890	Methyltransferase domain; Region: Methyltransf_31; pfam13847
158879000891	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879000892	S-adenosylmethionine binding site [chemical binding]; other site
158879000893	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
158879000894	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
158879000895	substrate binding site [chemical binding]; other site
158879000896	dimer interface [polypeptide binding]; other site
158879000897	ATP binding site [chemical binding]; other site
158879000898	D-ribose pyranase; Provisional; Region: PRK11797
158879000899	Sugar transport protein; Region: Sugar_transport; pfam06800
158879000900	Transcriptional regulators [Transcription]; Region: PurR; COG1609
158879000901	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
158879000902	DNA binding site [nucleotide binding]
158879000903	domain linker motif; other site
158879000904	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
158879000905	dimerization interface [polypeptide binding]; other site
158879000906	ligand binding site [chemical binding]; other site
158879000907	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879000908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879000909	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
158879000910	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
158879000911	active site
158879000912	Surface antigen [General function prediction only]; Region: COG3942
158879000913	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
158879000914	Peptidase family M23; Region: Peptidase_M23; pfam01551
158879000915	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
158879000916	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
158879000917	Walker A/P-loop; other site
158879000918	ATP binding site [chemical binding]; other site
158879000919	Q-loop/lid; other site
158879000920	ABC transporter signature motif; other site
158879000921	Walker B; other site
158879000922	D-loop; other site
158879000923	H-loop/switch region; other site
158879000924	Surface antigen [General function prediction only]; Region: COG3942
158879000925	CHAP domain; Region: CHAP; pfam05257
158879000926	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
158879000927	Predicted membrane protein [Function unknown]; Region: COG1511
158879000928	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
158879000929	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
158879000930	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
158879000931	Uncharacterized small protein [Function unknown]; Region: COG5417
158879000932	Predicted membrane protein [Function unknown]; Region: COG4499
158879000933	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
158879000934	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
158879000935	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
158879000936	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
158879000937	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
158879000938	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
158879000939	Uncharacterized conserved protein [Function unknown]; Region: COG5444
158879000940	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
158879000941	Protein of unknown function, DUF600; Region: DUF600; cl04640
158879000942	Protein of unknown function, DUF600; Region: DUF600; cl04640
158879000943	Protein of unknown function, DUF600; Region: DUF600; cl04640
158879000944	Protein of unknown function, DUF600; Region: DUF600; cl04640
158879000945	Protein of unknown function, DUF600; Region: DUF600; cl04640
158879000946	Protein of unknown function, DUF600; Region: DUF600; cl04640
158879000947	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
158879000948	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
158879000949	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
158879000950	5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533
158879000951	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
158879000952	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
158879000953	FtsX-like permease family; Region: FtsX; pfam02687
158879000954	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
158879000955	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
158879000956	Walker A/P-loop; other site
158879000957	ATP binding site [chemical binding]; other site
158879000958	Q-loop/lid; other site
158879000959	ABC transporter signature motif; other site
158879000960	Walker B; other site
158879000961	D-loop; other site
158879000962	H-loop/switch region; other site
158879000963	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
158879000964	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
158879000965	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
158879000966	non-specific DNA binding site [nucleotide binding]; other site
158879000967	salt bridge; other site
158879000968	sequence-specific DNA binding site [nucleotide binding]; other site
158879000969	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
158879000970	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
158879000971	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
158879000972	ATP binding site [chemical binding]; other site
158879000973	substrate binding site [chemical binding]; other site
158879000974	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
158879000975	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
158879000976	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
158879000977	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
158879000978	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
158879000979	putative transporter; Provisional; Region: PRK10484
158879000980	Na binding site [ion binding]; other site
158879000981	N-acetylneuraminate lyase; Provisional; Region: PRK04147
158879000982	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
158879000983	inhibitor site; inhibition site
158879000984	active site
158879000985	dimer interface [polypeptide binding]; other site
158879000986	catalytic residue [active]
158879000987	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
158879000988	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
158879000989	nucleotide binding site [chemical binding]; other site
158879000990	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
158879000991	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
158879000992	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
158879000993	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
158879000994	putative active site [active]
158879000995	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
158879000996	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
158879000997	putative active site cavity [active]
158879000998	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
158879000999	Nucleoside recognition; Region: Gate; pfam07670
158879001000	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
158879001001	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
158879001002	PGAP1-like protein; Region: PGAP1; pfam07819
158879001003	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
158879001004	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
158879001005	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
158879001006	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
158879001007	putative active site [active]
158879001008	putative FMN binding site [chemical binding]; other site
158879001009	putative substrate binding site [chemical binding]; other site
158879001010	putative catalytic residue [active]
158879001011	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
158879001012	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
158879001013	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
158879001014	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
158879001015	lipoyl attachment site [posttranslational modification]; other site
158879001016	Replication protein C N-terminal domain; Region: RP-C; pfam03428
158879001017	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
158879001018	putative ADP-ribose binding site [chemical binding]; other site
158879001019	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
158879001020	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
158879001021	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
158879001022	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
158879001023	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
158879001024	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
158879001025	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
158879001026	NADP binding site [chemical binding]; other site
158879001027	putative substrate binding site [chemical binding]; other site
158879001028	active site
158879001029	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
158879001030	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
158879001031	active site
158879001032	P-loop; other site
158879001033	phosphorylation site [posttranslational modification]
158879001034	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
158879001035	active site
158879001036	phosphorylation site [posttranslational modification]
158879001037	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
158879001038	HTH domain; Region: HTH_11; pfam08279
158879001039	HTH domain; Region: HTH_11; pfam08279
158879001040	PRD domain; Region: PRD; pfam00874
158879001041	PRD domain; Region: PRD; pfam00874
158879001042	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
158879001043	active site
158879001044	P-loop; other site
158879001045	phosphorylation site [posttranslational modification]
158879001046	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
158879001047	active site
158879001048	phosphorylation site [posttranslational modification]
158879001049	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
158879001050	MarR family; Region: MarR_2; pfam12802
158879001051	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
158879001052	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
158879001053	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815
158879001054	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
158879001055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879001056	putative substrate translocation pore; other site
158879001057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879001058	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
158879001059	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
158879001060	Zn binding site [ion binding]; other site
158879001061	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
158879001062	Zn binding site [ion binding]; other site
158879001063	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
158879001064	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
158879001065	Predicted flavoprotein [General function prediction only]; Region: COG0431
158879001066	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
158879001067	Predicted membrane protein [Function unknown]; Region: COG2855
158879001068	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
158879001069	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
158879001070	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
158879001071	Imelysin; Region: Peptidase_M75; pfam09375
158879001072	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
158879001073	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
158879001074	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
158879001075	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
158879001076	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
158879001077	Phage envelope protein [General function prediction only]; Region: COG5562
158879001078	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
158879001079	non-specific DNA binding site [nucleotide binding]; other site
158879001080	salt bridge; other site
158879001081	sequence-specific DNA binding site [nucleotide binding]; other site
158879001082	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
158879001083	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
158879001084	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
158879001085	Walker A/P-loop; other site
158879001086	ATP binding site [chemical binding]; other site
158879001087	Q-loop/lid; other site
158879001088	ABC transporter signature motif; other site
158879001089	Walker B; other site
158879001090	D-loop; other site
158879001091	H-loop/switch region; other site
158879001092	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
158879001093	Predicted membrane protein [Function unknown]; Region: COG4292
158879001094	putative acyltransferase; Provisional; Region: PRK05790
158879001095	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
158879001096	dimer interface [polypeptide binding]; other site
158879001097	active site
158879001098	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
158879001099	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
158879001100	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371
158879001101	THF binding site; other site
158879001102	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
158879001103	substrate binding site [chemical binding]; other site
158879001104	THF binding site; other site
158879001105	zinc-binding site [ion binding]; other site
158879001106	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
158879001107	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
158879001108	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
158879001109	FAD binding site [chemical binding]; other site
158879001110	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
158879001111	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
158879001112	homodimer interface [polypeptide binding]; other site
158879001113	substrate-cofactor binding pocket; other site
158879001114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879001115	catalytic residue [active]
158879001116	cystathionine gamma-synthase; Reviewed; Region: PRK08247
158879001117	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
158879001118	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
158879001119	catalytic residue [active]
158879001120	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
158879001121	ParB-like nuclease domain; Region: ParB; smart00470
158879001122	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
158879001123	Mechanosensitive ion channel; Region: MS_channel; pfam00924
158879001124	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481
158879001125	GTP-binding protein YchF; Reviewed; Region: PRK09601
158879001126	YchF GTPase; Region: YchF; cd01900
158879001127	G1 box; other site
158879001128	GTP/Mg2+ binding site [chemical binding]; other site
158879001129	Switch I region; other site
158879001130	G2 box; other site
158879001131	Switch II region; other site
158879001132	G3 box; other site
158879001133	G4 box; other site
158879001134	G5 box; other site
158879001135	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
158879001136	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
158879001137	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
158879001138	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
158879001139	dimer interface [polypeptide binding]; other site
158879001140	ssDNA binding site [nucleotide binding]; other site
158879001141	tetramer (dimer of dimers) interface [polypeptide binding]; other site
158879001142	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
158879001143	Abi-like protein; Region: Abi_2; pfam07751
158879001144	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
158879001145	DNA binding site [nucleotide binding]
158879001146	active site
158879001147	Int/Topo IB signature motif; other site
158879001148	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879001149	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
158879001150	Predicted membrane protein [Function unknown]; Region: COG3212
158879001151	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
158879001152	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
158879001153	non-specific DNA binding site [nucleotide binding]; other site
158879001154	salt bridge; other site
158879001155	sequence-specific DNA binding site [nucleotide binding]; other site
158879001156	Predicted membrane protein [Function unknown]; Region: COG2261
158879001157	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
158879001158	catalytic core [active]
158879001159	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
158879001160	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
158879001161	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
158879001162	catalytic residue [active]
158879001163	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
158879001164	catalytic residues [active]
158879001165	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
158879001166	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
158879001167	peroxiredoxin; Region: AhpC; TIGR03137
158879001168	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
158879001169	dimer interface [polypeptide binding]; other site
158879001170	decamer (pentamer of dimers) interface [polypeptide binding]; other site
158879001171	catalytic triad [active]
158879001172	peroxidatic and resolving cysteines [active]
158879001173	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
158879001174	dimer interface [polypeptide binding]; other site
158879001175	FMN binding site [chemical binding]; other site
158879001176	NADPH bind site [chemical binding]; other site
158879001177	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
158879001178	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
158879001179	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
158879001180	Transposase; Region: DDE_Tnp_ISL3; pfam01610
158879001181	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
158879001182	active site
158879001183	xanthine permease; Region: pbuX; TIGR03173
158879001184	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
158879001185	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
158879001186	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
158879001187	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
158879001188	active site
158879001189	GMP synthase; Reviewed; Region: guaA; PRK00074
158879001190	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
158879001191	AMP/PPi binding site [chemical binding]; other site
158879001192	candidate oxyanion hole; other site
158879001193	catalytic triad [active]
158879001194	potential glutamine specificity residues [chemical binding]; other site
158879001195	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
158879001196	ATP Binding subdomain [chemical binding]; other site
158879001197	Ligand Binding sites [chemical binding]; other site
158879001198	Dimerization subdomain; other site
158879001199	Pathogenicity island SaPIn2
158879001200	PemK-like protein; Region: PemK; pfam02452
158879001201	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
158879001202	Transposase; Region: HTH_Tnp_1; cl17663
158879001203	Predicted membrane protein [Function unknown]; Region: COG3759
158879001204	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
158879001205	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
158879001206	NADP binding site [chemical binding]; other site
158879001207	superantigen-like protein; Reviewed; Region: PRK13037
158879001208	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
158879001209	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879001210	superantigen-like protein; Reviewed; Region: PRK13041
158879001211	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
158879001212	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879001213	superantigen-like protein; Reviewed; Region: PRK13335
158879001214	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
158879001215	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879001216	superantigen-like protein; Reviewed; Region: PRK13042
158879001217	Mucin-like glycoprotein; Region: Mucin; pfam01456
158879001218	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
158879001219	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879001220	superantigen-like protein 5; Reviewed; Region: PRK13035
158879001221	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
158879001222	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879001223	superantigen-like protein 7; Reviewed; Region: PRK13346
158879001224	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
158879001225	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879001226	superantigen-like protein; Reviewed; Region: PRK13039
158879001227	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
158879001228	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879001229	superantigen-like protein; Reviewed; Region: PRK13345
158879001230	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
158879001231	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879001232	superantigen-like protein 5; Reviewed; Region: PRK13035
158879001233	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
158879001234	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879001235	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
158879001236	HsdM N-terminal domain; Region: HsdM_N; pfam12161
158879001237	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879001238	S-adenosylmethionine binding site [chemical binding]; other site
158879001239	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
158879001240	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
158879001241	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
158879001242	superantigen-like protein; Reviewed; Region: PRK13036
158879001243	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
158879001244	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879001245	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879001246	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879001247	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879001248	Protein of unknown function, DUF576; Region: DUF576; cl04553
158879001249	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879001250	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879001251	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879001252	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879001253	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879001254	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879001255	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
158879001256	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
158879001257	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
158879001258	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
158879001259	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
158879001260	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
158879001261	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
158879001262	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
158879001263	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
158879001264	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
158879001265	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
158879001266	active site
158879001267	Esterase/lipase [General function prediction only]; Region: COG1647
158879001268	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
158879001269	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
158879001270	Na2 binding site [ion binding]; other site
158879001271	putative substrate binding site 1 [chemical binding]; other site
158879001272	Na binding site 1 [ion binding]; other site
158879001273	putative substrate binding site 2 [chemical binding]; other site
158879001274	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
158879001275	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
158879001276	dimer interface [polypeptide binding]; other site
158879001277	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879001278	catalytic residue [active]
158879001279	cystathionine beta-lyase; Provisional; Region: PRK07671
158879001280	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
158879001281	homodimer interface [polypeptide binding]; other site
158879001282	substrate-cofactor binding pocket; other site
158879001283	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879001284	catalytic residue [active]
158879001285	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
158879001286	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
158879001287	Walker A/P-loop; other site
158879001288	ATP binding site [chemical binding]; other site
158879001289	Q-loop/lid; other site
158879001290	ABC transporter signature motif; other site
158879001291	Walker B; other site
158879001292	D-loop; other site
158879001293	H-loop/switch region; other site
158879001294	NIL domain; Region: NIL; pfam09383
158879001295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879001296	dimer interface [polypeptide binding]; other site
158879001297	conserved gate region; other site
158879001298	ABC-ATPase subunit interface; other site
158879001299	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
158879001300	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
158879001301	LysM domain; Region: LysM; pfam01476
158879001302	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
158879001303	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
158879001304	Surface antigen [General function prediction only]; Region: COG3942
158879001305	CHAP domain; Region: CHAP; pfam05257
158879001306	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
158879001307	nudix motif; other site
158879001308	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879001309	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
158879001310	Coenzyme A binding pocket [chemical binding]; other site
158879001311	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
158879001312	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
158879001313	Transcriptional regulator [Transcription]; Region: LysR; COG0583
158879001314	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
158879001315	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
158879001316	dimerization interface [polypeptide binding]; other site
158879001317	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
158879001318	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
158879001319	active site
158879001320	dimer interface [polypeptide binding]; other site
158879001321	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
158879001322	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
158879001323	active site
158879001324	FMN binding site [chemical binding]; other site
158879001325	substrate binding site [chemical binding]; other site
158879001326	3Fe-4S cluster binding site [ion binding]; other site
158879001327	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
158879001328	domain interface; other site
158879001329	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
158879001330	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
158879001331	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
158879001332	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
158879001333	active site turn [active]
158879001334	phosphorylation site [posttranslational modification]
158879001335	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
158879001336	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
158879001337	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
158879001338	Ca binding site [ion binding]; other site
158879001339	active site
158879001340	catalytic site [active]
158879001341	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
158879001342	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
158879001343	DNA-binding site [nucleotide binding]; DNA binding site
158879001344	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
158879001345	UTRA domain; Region: UTRA; pfam07702
158879001346	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
158879001347	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879001348	Coenzyme A binding pocket [chemical binding]; other site
158879001349	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
158879001350	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879001351	Walker A motif; other site
158879001352	ATP binding site [chemical binding]; other site
158879001353	Walker B motif; other site
158879001354	arginine finger; other site
158879001355	hypothetical protein; Validated; Region: PRK00153
158879001356	recombination protein RecR; Reviewed; Region: recR; PRK00076
158879001357	RecR protein; Region: RecR; pfam02132
158879001358	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
158879001359	putative active site [active]
158879001360	putative metal-binding site [ion binding]; other site
158879001361	tetramer interface [polypeptide binding]; other site
158879001362	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
158879001363	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
158879001364	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
158879001365	catalytic residue [active]
158879001366	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
158879001367	thymidylate kinase; Validated; Region: tmk; PRK00698
158879001368	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
158879001369	TMP-binding site; other site
158879001370	ATP-binding site [chemical binding]; other site
158879001371	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870
158879001372	DNA polymerase III subunit delta'; Validated; Region: PRK08058
158879001373	DNA polymerase III subunit delta'; Validated; Region: PRK08485
158879001374	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
158879001375	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467
158879001376	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
158879001377	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879001378	S-adenosylmethionine binding site [chemical binding]; other site
158879001379	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
158879001380	GIY-YIG motif/motif A; other site
158879001381	putative active site [active]
158879001382	putative metal binding site [ion binding]; other site
158879001383	Predicted methyltransferases [General function prediction only]; Region: COG0313
158879001384	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
158879001385	putative SAM binding site [chemical binding]; other site
158879001386	putative homodimer interface [polypeptide binding]; other site
158879001387	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
158879001388	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
158879001389	active site
158879001390	HIGH motif; other site
158879001391	KMSKS motif; other site
158879001392	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
158879001393	tRNA binding surface [nucleotide binding]; other site
158879001394	anticodon binding site; other site
158879001395	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
158879001396	dimer interface [polypeptide binding]; other site
158879001397	putative tRNA-binding site [nucleotide binding]; other site
158879001398	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
158879001399	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
158879001400	active site
158879001401	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
158879001402	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
158879001403	putative active site [active]
158879001404	putative metal binding site [ion binding]; other site
158879001405	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
158879001406	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
158879001407	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879001408	S-adenosylmethionine binding site [chemical binding]; other site
158879001409	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
158879001410	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
158879001411	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
158879001412	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
158879001413	pur operon repressor; Provisional; Region: PRK09213
158879001414	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
158879001415	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
158879001416	active site
158879001417	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
158879001418	homotrimer interaction site [polypeptide binding]; other site
158879001419	putative active site [active]
158879001420	regulatory protein SpoVG; Reviewed; Region: PRK13259
158879001421	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
158879001422	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
158879001423	Substrate binding site; other site
158879001424	Mg++ binding site; other site
158879001425	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
158879001426	active site
158879001427	substrate binding site [chemical binding]; other site
158879001428	CoA binding site [chemical binding]; other site
158879001429	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
158879001430	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
158879001431	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
158879001432	active site
158879001433	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
158879001434	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
158879001435	5S rRNA interface [nucleotide binding]; other site
158879001436	CTC domain interface [polypeptide binding]; other site
158879001437	L16 interface [polypeptide binding]; other site
158879001438	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
158879001439	putative active site [active]
158879001440	catalytic residue [active]
158879001441	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
158879001442	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
158879001443	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
158879001444	ATP binding site [chemical binding]; other site
158879001445	putative Mg++ binding site [ion binding]; other site
158879001446	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
158879001447	nucleotide binding region [chemical binding]; other site
158879001448	ATP-binding site [chemical binding]; other site
158879001449	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
158879001450	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
158879001451	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
158879001452	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
158879001453	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
158879001454	putative SAM binding site [chemical binding]; other site
158879001455	putative homodimer interface [polypeptide binding]; other site
158879001456	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
158879001457	homodimer interface [polypeptide binding]; other site
158879001458	metal binding site [ion binding]; metal-binding site
158879001459	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
158879001460	RNA binding surface [nucleotide binding]; other site
158879001461	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
158879001462	Septum formation initiator; Region: DivIC; pfam04977
158879001463	hypothetical protein; Provisional; Region: PRK08582
158879001464	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
158879001465	RNA binding site [nucleotide binding]; other site
158879001466	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
158879001467	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
158879001468	Ligand Binding Site [chemical binding]; other site
158879001469	TilS substrate C-terminal domain; Region: TilS_C; smart00977
158879001470	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
158879001471	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
158879001472	active site
158879001473	FtsH Extracellular; Region: FtsH_ext; pfam06480
158879001474	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
158879001475	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879001476	Walker A motif; other site
158879001477	ATP binding site [chemical binding]; other site
158879001478	Walker B motif; other site
158879001479	arginine finger; other site
158879001480	Peptidase family M41; Region: Peptidase_M41; pfam01434
158879001481	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
158879001482	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
158879001483	dimerization interface [polypeptide binding]; other site
158879001484	domain crossover interface; other site
158879001485	redox-dependent activation switch; other site
158879001486	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
158879001487	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
158879001488	dimer interface [polypeptide binding]; other site
158879001489	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879001490	catalytic residue [active]
158879001491	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
158879001492	dihydropteroate synthase; Region: DHPS; TIGR01496
158879001493	substrate binding pocket [chemical binding]; other site
158879001494	dimer interface [polypeptide binding]; other site
158879001495	inhibitor binding site; inhibition site
158879001496	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
158879001497	homooctamer interface [polypeptide binding]; other site
158879001498	active site
158879001499	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
158879001500	catalytic center binding site [active]
158879001501	ATP binding site [chemical binding]; other site
158879001502	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
158879001503	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
158879001504	dimer interface [polypeptide binding]; other site
158879001505	putative anticodon binding site; other site
158879001506	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
158879001507	motif 1; other site
158879001508	active site
158879001509	motif 2; other site
158879001510	motif 3; other site
158879001511	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
158879001512	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
158879001513	DNA-binding site [nucleotide binding]; DNA binding site
158879001514	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
158879001515	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879001516	homodimer interface [polypeptide binding]; other site
158879001517	catalytic residue [active]
158879001518	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
158879001519	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
158879001520	active site
158879001521	multimer interface [polypeptide binding]; other site
158879001522	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
158879001523	predicted active site [active]
158879001524	catalytic triad [active]
158879001525	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
158879001526	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
158879001527	Nucleoside recognition; Region: Gate; pfam07670
158879001528	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
158879001529	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
158879001530	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
158879001531	UvrB/uvrC motif; Region: UVR; pfam02151
158879001532	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
158879001533	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
158879001534	ADP binding site [chemical binding]; other site
158879001535	phosphagen binding site; other site
158879001536	substrate specificity loop; other site
158879001537	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
158879001538	Clp amino terminal domain; Region: Clp_N; pfam02861
158879001539	Clp amino terminal domain; Region: Clp_N; pfam02861
158879001540	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879001541	Walker A motif; other site
158879001542	ATP binding site [chemical binding]; other site
158879001543	Walker B motif; other site
158879001544	arginine finger; other site
158879001545	UvrB/uvrC motif; Region: UVR; pfam02151
158879001546	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879001547	Walker A motif; other site
158879001548	ATP binding site [chemical binding]; other site
158879001549	Walker B motif; other site
158879001550	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
158879001551	DNA repair protein RadA; Provisional; Region: PRK11823
158879001552	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
158879001553	Walker A motif/ATP binding site; other site
158879001554	ATP binding site [chemical binding]; other site
158879001555	Walker B motif; other site
158879001556	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
158879001557	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
158879001558	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
158879001559	putative active site [active]
158879001560	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
158879001561	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
158879001562	active site
158879001563	HIGH motif; other site
158879001564	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
158879001565	active site
158879001566	KMSKS motif; other site
158879001567	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
158879001568	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
158879001569	trimer interface [polypeptide binding]; other site
158879001570	active site
158879001571	substrate binding site [chemical binding]; other site
158879001572	CoA binding site [chemical binding]; other site
158879001573	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
158879001574	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
158879001575	active site
158879001576	HIGH motif; other site
158879001577	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
158879001578	KMSKS motif; other site
158879001579	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
158879001580	tRNA binding surface [nucleotide binding]; other site
158879001581	anticodon binding site; other site
158879001582	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
158879001583	active site
158879001584	dimerization interface [polypeptide binding]; other site
158879001585	metal binding site [ion binding]; metal-binding site
158879001586	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
158879001587	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
158879001588	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
158879001589	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
158879001590	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
158879001591	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
158879001592	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
158879001593	DNA binding residues [nucleotide binding]
158879001594	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
158879001595	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
158879001596	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
158879001597	putative homodimer interface [polypeptide binding]; other site
158879001598	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
158879001599	heterodimer interface [polypeptide binding]; other site
158879001600	homodimer interface [polypeptide binding]; other site
158879001601	similar to hypothetical protein
158879001602	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
158879001603	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
158879001604	23S rRNA interface [nucleotide binding]; other site
158879001605	L7/L12 interface [polypeptide binding]; other site
158879001606	putative thiostrepton binding site; other site
158879001607	L25 interface [polypeptide binding]; other site
158879001608	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
158879001609	mRNA/rRNA interface [nucleotide binding]; other site
158879001610	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
158879001611	23S rRNA interface [nucleotide binding]; other site
158879001612	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
158879001613	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
158879001614	peripheral dimer interface [polypeptide binding]; other site
158879001615	core dimer interface [polypeptide binding]; other site
158879001616	L10 interface [polypeptide binding]; other site
158879001617	L11 interface [polypeptide binding]; other site
158879001618	putative EF-Tu interaction site [polypeptide binding]; other site
158879001619	putative EF-G interaction site [polypeptide binding]; other site
158879001620	Methyltransferase domain; Region: Methyltransf_31; pfam13847
158879001621	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879001622	S-adenosylmethionine binding site [chemical binding]; other site
158879001623	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
158879001624	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
158879001625	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
158879001626	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
158879001627	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
158879001628	RPB10 interaction site [polypeptide binding]; other site
158879001629	RPB1 interaction site [polypeptide binding]; other site
158879001630	RPB11 interaction site [polypeptide binding]; other site
158879001631	RPB3 interaction site [polypeptide binding]; other site
158879001632	RPB12 interaction site [polypeptide binding]; other site
158879001633	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
158879001634	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
158879001635	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
158879001636	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
158879001637	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
158879001638	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
158879001639	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
158879001640	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
158879001641	G-loop; other site
158879001642	DNA binding site [nucleotide binding]
158879001643	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600
158879001644	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
158879001645	S17 interaction site [polypeptide binding]; other site
158879001646	S8 interaction site; other site
158879001647	16S rRNA interaction site [nucleotide binding]; other site
158879001648	streptomycin interaction site [chemical binding]; other site
158879001649	23S rRNA interaction site [nucleotide binding]; other site
158879001650	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
158879001651	30S ribosomal protein S7; Validated; Region: PRK05302
158879001652	elongation factor G; Reviewed; Region: PRK00007
158879001653	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
158879001654	G1 box; other site
158879001655	putative GEF interaction site [polypeptide binding]; other site
158879001656	GTP/Mg2+ binding site [chemical binding]; other site
158879001657	Switch I region; other site
158879001658	G2 box; other site
158879001659	G3 box; other site
158879001660	Switch II region; other site
158879001661	G4 box; other site
158879001662	G5 box; other site
158879001663	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
158879001664	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
158879001665	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
158879001666	elongation factor Tu; Reviewed; Region: PRK00049
158879001667	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
158879001668	G1 box; other site
158879001669	GEF interaction site [polypeptide binding]; other site
158879001670	GTP/Mg2+ binding site [chemical binding]; other site
158879001671	Switch I region; other site
158879001672	G2 box; other site
158879001673	G3 box; other site
158879001674	Switch II region; other site
158879001675	G4 box; other site
158879001676	G5 box; other site
158879001677	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
158879001678	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
158879001679	Antibiotic Binding Site [chemical binding]; other site
158879001680	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
158879001681	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
158879001682	metal binding site [ion binding]; metal-binding site
158879001683	dimer interface [polypeptide binding]; other site
158879001684	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
158879001685	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
158879001686	substrate-cofactor binding pocket; other site
158879001687	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879001688	catalytic residue [active]
158879001689	chaperone protein HchA; Provisional; Region: PRK04155
158879001690	Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148
158879001691	dimer interface [polypeptide binding]; other site
158879001692	metal binding site [ion binding]; metal-binding site
158879001693	potential oxyanion hole; other site
158879001694	potential catalytic triad [active]
158879001695	conserved cys residue [active]
158879001696	ribulokinase; Provisional; Region: PRK04123
158879001697	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
158879001698	N- and C-terminal domain interface [polypeptide binding]; other site
158879001699	active site
158879001700	MgATP binding site [chemical binding]; other site
158879001701	catalytic site [active]
158879001702	metal binding site [ion binding]; metal-binding site
158879001703	carbohydrate binding site [chemical binding]; other site
158879001704	homodimer interface [polypeptide binding]; other site
158879001705	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
158879001706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
158879001707	NAD(P) binding site [chemical binding]; other site
158879001708	active site
158879001709	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
158879001710	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
158879001711	homodimer interface [polypeptide binding]; other site
158879001712	substrate-cofactor binding pocket; other site
158879001713	catalytic residue [active]
158879001714	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
158879001715	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879001716	motif II; other site
158879001717	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
158879001718	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
158879001719	Substrate-binding site [chemical binding]; other site
158879001720	Substrate specificity [chemical binding]; other site
158879001721	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
158879001722	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
158879001723	Substrate-binding site [chemical binding]; other site
158879001724	Substrate specificity [chemical binding]; other site
158879001725	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
158879001726	nucleoside/Zn binding site; other site
158879001727	dimer interface [polypeptide binding]; other site
158879001728	catalytic motif [active]
158879001729	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879001730	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
158879001731	active site
158879001732	motif I; other site
158879001733	motif II; other site
158879001734	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879001735	Predicted flavoprotein [General function prediction only]; Region: COG0431
158879001736	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
158879001737	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
158879001738	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
158879001739	Cna protein B-type domain; Region: Cna_B; pfam05738
158879001740	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
158879001741	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
158879001742	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
158879001743	Cna protein B-type domain; Region: Cna_B; pfam05738
158879001744	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
158879001745	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
158879001746	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
158879001747	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
158879001748	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
158879001749	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
158879001750	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
158879001751	Cna protein B-type domain; Region: Cna_B; pfam05738
158879001752	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
158879001753	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
158879001754	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
158879001755	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
158879001756	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
158879001757	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
158879001758	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
158879001759	putative GTP cyclohydrolase; Provisional; Region: PRK13674
158879001760	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
158879001761	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
158879001762	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
158879001763	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
158879001764	active site
158879001765	trimer interface [polypeptide binding]; other site
158879001766	allosteric site; other site
158879001767	active site lid [active]
158879001768	hexamer (dimer of trimers) interface [polypeptide binding]; other site
158879001769	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
158879001770	active site
158879001771	dimer interface [polypeptide binding]; other site
158879001772	magnesium binding site [ion binding]; other site
158879001773	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
158879001774	tetramer interface [polypeptide binding]; other site
158879001775	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
158879001776	active site
158879001777	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
158879001778	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879001779	motif II; other site
158879001780	proline/glycine betaine transporter; Provisional; Region: PRK10642
158879001781	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879001782	putative substrate translocation pore; other site
158879001783	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
158879001784	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
158879001785	acyl-activating enzyme (AAE) consensus motif; other site
158879001786	AMP binding site [chemical binding]; other site
158879001787	active site
158879001788	CoA binding site [chemical binding]; other site
158879001789	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
158879001790	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
158879001791	dimer interface [polypeptide binding]; other site
158879001792	active site
158879001793	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
158879001794	dimer interface [polypeptide binding]; other site
158879001795	substrate binding site [chemical binding]; other site
158879001796	ATP binding site [chemical binding]; other site
158879001797	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
158879001798	ligand binding site [chemical binding]; other site
158879001799	active site
158879001800	UGI interface [polypeptide binding]; other site
158879001801	catalytic site [active]
158879001802	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
158879001803	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
158879001804	Uncharacterized conserved protein [Function unknown]; Region: COG3610
158879001805	Uncharacterized conserved protein [Function unknown]; Region: COG2966
158879001806	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
158879001807	putative heme peroxidase; Provisional; Region: PRK12276
158879001808	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
158879001809	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
158879001810	mevalonate kinase; Region: mevalon_kin; TIGR00549
158879001811	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
158879001812	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
158879001813	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
158879001814	diphosphomevalonate decarboxylase; Region: PLN02407
158879001815	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
158879001816	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
158879001817	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
158879001818	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
158879001819	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
158879001820	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
158879001821	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
158879001822	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
158879001823	Predicted transcriptional regulator [Transcription]; Region: COG1959
158879001824	Transcriptional regulator; Region: Rrf2; pfam02082
158879001825	LXG domain of WXG superfamily; Region: LXG; pfam04740
158879001826	Protein of unknown function (DUF443); Region: DUF443; pfam04276
158879001827	Protein of unknown function (DUF443); Region: DUF443; pfam04276
158879001828	Protein of unknown function (DUF443); Region: DUF443; pfam04276
158879001829	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
158879001830	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
158879001831	active site
158879001832	catalytic tetrad [active]
158879001833	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
158879001834	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
158879001835	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
158879001836	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879001837	Coenzyme A binding pocket [chemical binding]; other site
158879001838	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
158879001839	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
158879001840	Zn2+ binding site [ion binding]; other site
158879001841	Mg2+ binding site [ion binding]; other site
158879001842	YwhD family; Region: YwhD; pfam08741
158879001843	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
158879001844	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
158879001845	NAD binding site [chemical binding]; other site
158879001846	substrate binding site [chemical binding]; other site
158879001847	catalytic Zn binding site [ion binding]; other site
158879001848	tetramer interface [polypeptide binding]; other site
158879001849	structural Zn binding site [ion binding]; other site
158879001850	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
158879001851	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
158879001852	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
158879001853	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
158879001854	active site
158879001855	HIGH motif; other site
158879001856	KMSK motif region; other site
158879001857	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
158879001858	tRNA binding surface [nucleotide binding]; other site
158879001859	anticodon binding site; other site
158879001860	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
158879001861	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
158879001862	minor groove reading motif; other site
158879001863	helix-hairpin-helix signature motif; other site
158879001864	substrate binding pocket [chemical binding]; other site
158879001865	active site
158879001866	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
158879001867	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
158879001868	putative binding site residues; other site
158879001869	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
158879001870	ABC-ATPase subunit  interface; other site
158879001871	dimer interface [polypeptide binding]; other site
158879001872	putative PBP binding regions; other site
158879001873	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
158879001874	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879001875	motif II; other site
158879001876	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
158879001877	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
158879001878	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
158879001879	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
158879001880	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
158879001881	Transcriptional regulators [Transcription]; Region: MarR; COG1846
158879001882	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
158879001883	Protein of unknown function, DUF606; Region: DUF606; pfam04657
158879001884	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
158879001885	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
158879001886	active site
158879001887	DNA binding site [nucleotide binding]
158879001888	Int/Topo IB signature motif; other site
158879001889	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646
158879001890	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
158879001891	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
158879001892	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574
158879001893	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660
158879001894	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
158879001895	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
158879001896	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
158879001897	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657
158879001898	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
158879001899	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
158879001900	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
158879001901	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
158879001902	Transposase; Region: DDE_Tnp_ISL3; pfam01610
158879001903	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
158879001904	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
158879001905	metal binding site [ion binding]; metal-binding site
158879001906	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
158879001907	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
158879001908	ABC-ATPase subunit  interface; other site
158879001909	dimer interface [polypeptide binding]; other site
158879001910	putative PBP binding regions; other site
158879001911	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
158879001912	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
158879001913	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
158879001914	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
158879001915	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
158879001916	FeoA domain; Region: FeoA; pfam04023
158879001917	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
158879001918	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
158879001919	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
158879001920	teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546
158879001921	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
158879001922	Walker A/P-loop; other site
158879001923	ATP binding site [chemical binding]; other site
158879001924	Q-loop/lid; other site
158879001925	ABC transporter signature motif; other site
158879001926	Walker B; other site
158879001927	D-loop; other site
158879001928	H-loop/switch region; other site
158879001929	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
158879001930	ABC-2 type transporter; Region: ABC2_membrane; cl17235
158879001931	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
158879001932	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
158879001933	active site
158879001934	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
158879001935	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
158879001936	active site
158879001937	nucleotide binding site [chemical binding]; other site
158879001938	HIGH motif; other site
158879001939	KMSKS motif; other site
158879001940	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
158879001941	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
158879001942	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
158879001943	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
158879001944	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
158879001945	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
158879001946	Walker A/P-loop; other site
158879001947	ATP binding site [chemical binding]; other site
158879001948	Q-loop/lid; other site
158879001949	ABC transporter signature motif; other site
158879001950	Walker B; other site
158879001951	D-loop; other site
158879001952	H-loop/switch region; other site
158879001953	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
158879001954	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
158879001955	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
158879001956	Uncharacterized conserved protein [Function unknown]; Region: COG1284
158879001957	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
158879001958	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
158879001959	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
158879001960	Walker A/P-loop; other site
158879001961	ATP binding site [chemical binding]; other site
158879001962	Q-loop/lid; other site
158879001963	ABC transporter signature motif; other site
158879001964	Walker B; other site
158879001965	D-loop; other site
158879001966	H-loop/switch region; other site
158879001967	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
158879001968	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
158879001969	ABC-ATPase subunit  interface; other site
158879001970	dimer interface [polypeptide binding]; other site
158879001971	putative PBP binding regions; other site
158879001972	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
158879001973	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
158879001974	ABC-ATPase subunit  interface; other site
158879001975	dimer interface [polypeptide binding]; other site
158879001976	putative PBP binding regions; other site
158879001977	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
158879001978	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
158879001979	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
158879001980	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
158879001981	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
158879001982	Uncharacterized membrane protein [Function unknown]; Region: COG3949
158879001983	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
158879001984	Na binding site [ion binding]; other site
158879001985	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
158879001986	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
158879001987	substrate binding pocket [chemical binding]; other site
158879001988	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
158879001989	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
158879001990	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879001991	Coenzyme A binding pocket [chemical binding]; other site
158879001992	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
158879001993	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
158879001994	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
158879001995	NAD(P) binding site [chemical binding]; other site
158879001996	active site
158879001997	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
158879001998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879001999	active site
158879002000	phosphorylation site [posttranslational modification]
158879002001	intermolecular recognition site; other site
158879002002	dimerization interface [polypeptide binding]; other site
158879002003	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
158879002004	DNA binding site [nucleotide binding]
158879002005	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
158879002006	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
158879002007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879002008	ATP binding site [chemical binding]; other site
158879002009	Mg2+ binding site [ion binding]; other site
158879002010	G-X-G motif; other site
158879002011	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
158879002012	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
158879002013	Walker A/P-loop; other site
158879002014	ATP binding site [chemical binding]; other site
158879002015	Q-loop/lid; other site
158879002016	ABC transporter signature motif; other site
158879002017	Walker B; other site
158879002018	D-loop; other site
158879002019	H-loop/switch region; other site
158879002020	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
158879002021	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
158879002022	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
158879002023	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
158879002024	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
158879002025	Surface antigen [General function prediction only]; Region: COG3942
158879002026	CHAP domain; Region: CHAP; pfam05257
158879002027	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
158879002028	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
158879002029	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
158879002030	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
158879002031	hypothetical protein; Provisional; Region: PRK12378
158879002032	Uncharacterized conserved protein [Function unknown]; Region: COG3542
158879002033	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
158879002034	Transcriptional regulator [Transcription]; Region: LysR; COG0583
158879002035	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
158879002036	dimerization interface [polypeptide binding]; other site
158879002037	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879002038	sugar efflux transporter; Region: 2A0120; TIGR00899
158879002039	putative substrate translocation pore; other site
158879002040	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
158879002041	Serine incorporator (Serinc); Region: Serinc; pfam03348
158879002042	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879002043	Coenzyme A binding pocket [chemical binding]; other site
158879002044	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
158879002045	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
158879002046	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
158879002047	hypothetical protein; Validated; Region: PRK00124
158879002048	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
158879002049	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
158879002050	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
158879002051	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
158879002052	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
158879002053	Walker A/P-loop; other site
158879002054	ATP binding site [chemical binding]; other site
158879002055	Q-loop/lid; other site
158879002056	ABC transporter signature motif; other site
158879002057	Walker B; other site
158879002058	D-loop; other site
158879002059	H-loop/switch region; other site
158879002060	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
158879002061	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
158879002062	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
158879002063	Walker A/P-loop; other site
158879002064	ATP binding site [chemical binding]; other site
158879002065	Q-loop/lid; other site
158879002066	ABC transporter signature motif; other site
158879002067	Walker B; other site
158879002068	D-loop; other site
158879002069	H-loop/switch region; other site
158879002070	Transcriptional regulators [Transcription]; Region: MarR; COG1846
158879002071	MarR family; Region: MarR; pfam01047
158879002072	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
158879002073	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
158879002074	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
158879002075	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
158879002076	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
158879002077	active site
158879002078	catalytic tetrad [active]
158879002079	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
158879002080	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
158879002081	transmembrane helices; other site
158879002082	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
158879002083	DNA photolyase; Region: DNA_photolyase; pfam00875
158879002084	Predicted membrane protein [Function unknown]; Region: COG4330
158879002085	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
158879002086	trimer interface [polypeptide binding]; other site
158879002087	putative Zn binding site [ion binding]; other site
158879002088	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
158879002089	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879002090	putative substrate translocation pore; other site
158879002091	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
158879002092	putative deacylase active site [active]
158879002093	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
158879002094	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
158879002095	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
158879002096	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
158879002097	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
158879002098	putative substrate binding site [chemical binding]; other site
158879002099	putative ATP binding site [chemical binding]; other site
158879002100	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
158879002101	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
158879002102	active site
158879002103	phosphorylation site [posttranslational modification]
158879002104	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
158879002105	active site
158879002106	P-loop; other site
158879002107	phosphorylation site [posttranslational modification]
158879002108	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
158879002109	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
158879002110	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
158879002111	active site
158879002112	dimer interface [polypeptide binding]; other site
158879002113	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
158879002114	Domain of unknown function DUF21; Region: DUF21; pfam01595
158879002115	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
158879002116	Transporter associated domain; Region: CorC_HlyC; pfam03471
158879002117	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
158879002118	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
158879002119	active site
158879002120	catalytic tetrad [active]
158879002121	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
158879002122	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
158879002123	Ligand binding site; other site
158879002124	Putative Catalytic site; other site
158879002125	DXD motif; other site
158879002126	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
158879002127	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
158879002128	dimer interface [polypeptide binding]; other site
158879002129	phosphorylation site [posttranslational modification]
158879002130	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879002131	ATP binding site [chemical binding]; other site
158879002132	Mg2+ binding site [ion binding]; other site
158879002133	G-X-G motif; other site
158879002134	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
158879002135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879002136	active site
158879002137	phosphorylation site [posttranslational modification]
158879002138	intermolecular recognition site; other site
158879002139	dimerization interface [polypeptide binding]; other site
158879002140	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
158879002141	DNA binding site [nucleotide binding]
158879002142	Electron transfer DM13; Region: DM13; pfam10517
158879002143	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
158879002144	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
158879002145	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
158879002146	active site
158879002147	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
158879002148	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
158879002149	Ligand Binding Site [chemical binding]; other site
158879002150	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
158879002151	Glutamine amidotransferase class-I; Region: GATase; pfam00117
158879002152	glutamine binding [chemical binding]; other site
158879002153	catalytic triad [active]
158879002154	aminodeoxychorismate synthase; Provisional; Region: PRK07508
158879002155	chorismate binding enzyme; Region: Chorismate_bind; cl10555
158879002156	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
158879002157	substrate-cofactor binding pocket; other site
158879002158	Aminotransferase class IV; Region: Aminotran_4; pfam01063
158879002159	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879002160	catalytic residue [active]
158879002161	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
158879002162	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
158879002163	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
158879002164	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
158879002165	Sulfatase; Region: Sulfatase; pfam00884
158879002166	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
158879002167	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
158879002168	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
158879002169	ABC transporter; Region: ABC_tran_2; pfam12848
158879002170	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
158879002171	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
158879002172	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
158879002173	ATP binding site [chemical binding]; other site
158879002174	putative Mg++ binding site [ion binding]; other site
158879002175	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
158879002176	nucleotide binding region [chemical binding]; other site
158879002177	ATP-binding site [chemical binding]; other site
158879002178	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
158879002179	HRDC domain; Region: HRDC; pfam00570
158879002180	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
158879002181	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
158879002182	Walker A/P-loop; other site
158879002183	ATP binding site [chemical binding]; other site
158879002184	Q-loop/lid; other site
158879002185	ABC transporter signature motif; other site
158879002186	Walker B; other site
158879002187	D-loop; other site
158879002188	H-loop/switch region; other site
158879002189	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
158879002190	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879002191	dimer interface [polypeptide binding]; other site
158879002192	conserved gate region; other site
158879002193	ABC-ATPase subunit interface; other site
158879002194	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
158879002195	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
158879002196	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
158879002197	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
158879002198	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879002199	homodimer interface [polypeptide binding]; other site
158879002200	catalytic residue [active]
158879002201	5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502
158879002202	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
158879002203	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
158879002204	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
158879002205	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879002206	putative substrate translocation pore; other site
158879002207	POT family; Region: PTR2; cl17359
158879002208	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
158879002209	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
158879002210	Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780
158879002211	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
158879002212	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
158879002213	Class I ribonucleotide reductase; Region: RNR_I; cd01679
158879002214	active site
158879002215	dimer interface [polypeptide binding]; other site
158879002216	catalytic residues [active]
158879002217	effector binding site; other site
158879002218	R2 peptide binding site; other site
158879002219	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
158879002220	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
158879002221	dimer interface [polypeptide binding]; other site
158879002222	putative radical transfer pathway; other site
158879002223	diiron center [ion binding]; other site
158879002224	tyrosyl radical; other site
158879002225	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
158879002226	ABC-ATPase subunit  interface; other site
158879002227	dimer interface [polypeptide binding]; other site
158879002228	putative PBP binding regions; other site
158879002229	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
158879002230	ABC-ATPase subunit  interface; other site
158879002231	dimer interface [polypeptide binding]; other site
158879002232	putative PBP binding regions; other site
158879002233	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
158879002234	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
158879002235	Walker A/P-loop; other site
158879002236	ATP binding site [chemical binding]; other site
158879002237	Q-loop/lid; other site
158879002238	ABC transporter signature motif; other site
158879002239	Walker B; other site
158879002240	D-loop; other site
158879002241	H-loop/switch region; other site
158879002242	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
158879002243	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
158879002244	putative ligand binding residues [chemical binding]; other site
158879002245	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
158879002246	CHY zinc finger; Region: zf-CHY; pfam05495
158879002247	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906
158879002248	FAD binding domain; Region: FAD_binding_4; pfam01565
158879002249	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
158879002250	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
158879002251	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
158879002252	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
158879002253	peptidase T; Region: peptidase-T; TIGR01882
158879002254	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
158879002255	metal binding site [ion binding]; metal-binding site
158879002256	dimer interface [polypeptide binding]; other site
158879002257	Uncharacterized conserved protein [Function unknown]; Region: COG3610
158879002258	Uncharacterized conserved protein [Function unknown]; Region: COG2966
158879002259	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
158879002260	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
158879002261	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
158879002262	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
158879002263	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
158879002264	metal binding site [ion binding]; metal-binding site
158879002265	active site
158879002266	I-site; other site
158879002267	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
158879002268	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
158879002269	Mg++ binding site [ion binding]; other site
158879002270	putative catalytic motif [active]
158879002271	substrate binding site [chemical binding]; other site
158879002272	Uncharacterized conserved protein [Function unknown]; Region: COG1739
158879002273	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
158879002274	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
158879002275	EDD domain protein, DegV family; Region: DegV; TIGR00762
158879002276	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
158879002277	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
158879002278	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
158879002279	putative Mg++ binding site [ion binding]; other site
158879002280	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
158879002281	nucleotide binding region [chemical binding]; other site
158879002282	ATP-binding site [chemical binding]; other site
158879002283	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
158879002284	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
158879002285	active site
158879002286	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
158879002287	30S subunit binding site; other site
158879002288	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
158879002289	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
158879002290	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
158879002291	nucleotide binding region [chemical binding]; other site
158879002292	ATP-binding site [chemical binding]; other site
158879002293	SEC-C motif; Region: SEC-C; pfam02810
158879002294	peptide chain release factor 2; Provisional; Region: PRK06746
158879002295	This domain is found in peptide chain release factors; Region: PCRF; smart00937
158879002296	RF-1 domain; Region: RF-1; pfam00472
158879002297	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
158879002298	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
158879002299	Surface antigen [General function prediction only]; Region: COG3942
158879002300	CHAP domain; Region: CHAP; pfam05257
158879002301	HD domain; Region: HD_3; cl17350
158879002302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897
158879002303	excinuclease ABC subunit B; Provisional; Region: PRK05298
158879002304	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
158879002305	ATP binding site [chemical binding]; other site
158879002306	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
158879002307	nucleotide binding region [chemical binding]; other site
158879002308	ATP-binding site [chemical binding]; other site
158879002309	Ultra-violet resistance protein B; Region: UvrB; pfam12344
158879002310	UvrB/uvrC motif; Region: UVR; pfam02151
158879002311	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
158879002312	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
158879002313	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
158879002314	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
158879002315	HPr kinase/phosphorylase; Provisional; Region: PRK05428
158879002316	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
158879002317	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
158879002318	Hpr binding site; other site
158879002319	active site
158879002320	homohexamer subunit interaction site [polypeptide binding]; other site
158879002321	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
158879002322	putative acyl transferase; Provisional; Region: PRK10191
158879002323	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
158879002324	trimer interface [polypeptide binding]; other site
158879002325	active site
158879002326	substrate binding site [chemical binding]; other site
158879002327	CoA binding site [chemical binding]; other site
158879002328	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
158879002329	binding surface
158879002330	TPR motif; other site
158879002331	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
158879002332	TPR motif; other site
158879002333	binding surface
158879002334	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
158879002335	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
158879002336	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
158879002337	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
158879002338	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
158879002339	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
158879002340	phosphate binding site [ion binding]; other site
158879002341	dimer interface [polypeptide binding]; other site
158879002342	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
158879002343	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
158879002344	Clp protease; Region: CLP_protease; pfam00574
158879002345	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
158879002346	oligomer interface [polypeptide binding]; other site
158879002347	active site residues [active]
158879002348	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
158879002349	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
158879002350	NAD(P) binding site [chemical binding]; other site
158879002351	active site
158879002352	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
158879002353	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
158879002354	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
158879002355	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
158879002356	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
158879002357	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
158879002358	Phosphoglycerate kinase; Region: PGK; pfam00162
158879002359	substrate binding site [chemical binding]; other site
158879002360	hinge regions; other site
158879002361	ADP binding site [chemical binding]; other site
158879002362	catalytic site [active]
158879002363	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
158879002364	triosephosphate isomerase; Provisional; Region: PRK14565
158879002365	substrate binding site [chemical binding]; other site
158879002366	dimer interface [polypeptide binding]; other site
158879002367	catalytic triad [active]
158879002368	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
158879002369	phosphoglyceromutase; Provisional; Region: PRK05434
158879002370	enolase; Provisional; Region: eno; PRK00077
158879002371	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
158879002372	dimer interface [polypeptide binding]; other site
158879002373	metal binding site [ion binding]; metal-binding site
158879002374	substrate binding pocket [chemical binding]; other site
158879002375	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
158879002376	Esterase/lipase [General function prediction only]; Region: COG1647
158879002377	ribonuclease R; Region: RNase_R; TIGR02063
158879002378	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
158879002379	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
158879002380	RNB domain; Region: RNB; pfam00773
158879002381	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
158879002382	RNA binding site [nucleotide binding]; other site
158879002383	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
158879002384	SmpB-tmRNA interface; other site
158879002385	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879002386	Coenzyme A binding pocket [chemical binding]; other site
158879002387	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
158879002388	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
158879002389	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
158879002390	Staphylococcal nuclease homologues; Region: SNc; smart00318
158879002391	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
158879002392	Catalytic site; other site
158879002393	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
158879002394	DNA-binding site [nucleotide binding]; DNA binding site
158879002395	RNA-binding motif; other site
158879002396	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
158879002397	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
158879002398	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
158879002399	catalytic core [active]
158879002400	Lysine efflux permease [General function prediction only]; Region: COG1279
158879002401	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
158879002402	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
158879002403	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
158879002404	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
158879002405	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
158879002406	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
158879002407	active site
158879002408	catalytic residue [active]
158879002409	dimer interface [polypeptide binding]; other site
158879002410	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
158879002411	putative FMN binding site [chemical binding]; other site
158879002412	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
158879002413	catalytic residues [active]
158879002414	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
158879002415	ArsC family; Region: ArsC; pfam03960
158879002416	putative ArsC-like catalytic residues; other site
158879002417	putative TRX-like catalytic residues [active]
158879002418	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
158879002419	lipoyl attachment site [posttranslational modification]; other site
158879002420	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
158879002421	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
158879002422	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
158879002423	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
158879002424	Int/Topo IB signature motif; other site
158879002425	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
158879002426	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
158879002427	Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195
158879002428	Int/Topo IB signature motif; other site
158879002429	aminoglycoside resistance protein; Provisional; Region: PRK13746
158879002430	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
158879002431	active site
158879002432	NTP binding site [chemical binding]; other site
158879002433	metal binding triad [ion binding]; metal-binding site
158879002434	antibiotic binding site [chemical binding]; other site
158879002435	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
158879002436	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
158879002437	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879002438	S-adenosylmethionine binding site [chemical binding]; other site
158879002439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879002440	S-adenosylmethionine binding site [chemical binding]; other site
158879002441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
158879002442	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
158879002443	putative active site [active]
158879002444	putative metal binding site [ion binding]; other site
158879002445	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
158879002446	catalytic residues [active]
158879002447	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
158879002448	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
158879002449	Walker A/P-loop; other site
158879002450	ATP binding site [chemical binding]; other site
158879002451	Q-loop/lid; other site
158879002452	ABC transporter signature motif; other site
158879002453	Walker B; other site
158879002454	D-loop; other site
158879002455	H-loop/switch region; other site
158879002456	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
158879002457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879002458	dimer interface [polypeptide binding]; other site
158879002459	conserved gate region; other site
158879002460	ABC-ATPase subunit interface; other site
158879002461	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
158879002462	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
158879002463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
158879002464	Predicted membrane protein [Function unknown]; Region: COG2035
158879002465	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
158879002466	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
158879002467	Walker A/P-loop; other site
158879002468	ATP binding site [chemical binding]; other site
158879002469	Q-loop/lid; other site
158879002470	ABC transporter signature motif; other site
158879002471	Walker B; other site
158879002472	D-loop; other site
158879002473	H-loop/switch region; other site
158879002474	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
158879002475	FeS assembly protein SufD; Region: sufD; TIGR01981
158879002476	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
158879002477	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
158879002478	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
158879002479	catalytic residue [active]
158879002480	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
158879002481	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
158879002482	trimerization site [polypeptide binding]; other site
158879002483	active site
158879002484	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
158879002485	FeS assembly protein SufB; Region: sufB; TIGR01980
158879002486	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
158879002487	Domain of unknown function DUF21; Region: DUF21; pfam01595
158879002488	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
158879002489	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
158879002490	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
158879002491	FMN binding site [chemical binding]; other site
158879002492	substrate binding site [chemical binding]; other site
158879002493	putative catalytic residue [active]
158879002494	Uncharacterized conserved protein [Function unknown]; Region: COG1801
158879002495	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
158879002496	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
158879002497	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
158879002498	active site
158879002499	metal binding site [ion binding]; metal-binding site
158879002500	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
158879002501	lipoyl synthase; Provisional; Region: PRK05481
158879002502	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
158879002503	FeS/SAM binding site; other site
158879002504	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
158879002505	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
158879002506	Transposase; Region: DDE_Tnp_ISL3; pfam01610
158879002507	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
158879002508	Uncharacterized conserved protein [Function unknown]; Region: COG2445
158879002509	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
158879002510	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879002511	active site
158879002512	motif I; other site
158879002513	motif II; other site
158879002514	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879002515	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
158879002516	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
158879002517	dimerization interface [polypeptide binding]; other site
158879002518	ligand binding site [chemical binding]; other site
158879002519	NADP binding site [chemical binding]; other site
158879002520	catalytic site [active]
158879002521	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
158879002522	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
158879002523	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
158879002524	acyl-activating enzyme (AAE) consensus motif; other site
158879002525	AMP binding site [chemical binding]; other site
158879002526	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
158879002527	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
158879002528	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
158879002529	DltD N-terminal region; Region: DltD_N; pfam04915
158879002530	DltD central region; Region: DltD_M; pfam04918
158879002531	DltD C-terminal region; Region: DltD_C; pfam04914
158879002532	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
158879002533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
158879002534	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
158879002535	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
158879002536	hypothetical protein; Provisional; Region: PRK13669
158879002537	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
158879002538	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
158879002539	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
158879002540	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
158879002541	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
158879002542	interface (dimer of trimers) [polypeptide binding]; other site
158879002543	Substrate-binding/catalytic site; other site
158879002544	Zn-binding sites [ion binding]; other site
158879002545	Predicted permease [General function prediction only]; Region: COG2056
158879002546	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
158879002547	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
158879002548	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
158879002549	CoenzymeA binding site [chemical binding]; other site
158879002550	subunit interaction site [polypeptide binding]; other site
158879002551	PHB binding site; other site
158879002552	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
158879002553	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
158879002554	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587
158879002555	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
158879002556	Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942
158879002557	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
158879002558	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
158879002559	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
158879002560	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
158879002561	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
158879002562	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
158879002563	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
158879002564	Kinase associated protein B; Region: KapB; pfam08810
158879002565	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
158879002566	active site
158879002567	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
158879002568	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
158879002569	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
158879002570	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
158879002571	putative active site [active]
158879002572	putative FMN binding site [chemical binding]; other site
158879002573	putative substrate binding site [chemical binding]; other site
158879002574	putative catalytic residue [active]
158879002575	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
158879002576	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
158879002577	inhibitor-cofactor binding pocket; inhibition site
158879002578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879002579	catalytic residue [active]
158879002580	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
158879002581	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
158879002582	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
158879002583	NAD(P) binding site [chemical binding]; other site
158879002584	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
158879002585	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
158879002586	active site
158879002587	catalytic site [active]
158879002588	metal binding site [ion binding]; metal-binding site
158879002589	argininosuccinate lyase; Provisional; Region: PRK00855
158879002590	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
158879002591	active sites [active]
158879002592	tetramer interface [polypeptide binding]; other site
158879002593	argininosuccinate synthase; Provisional; Region: PRK13820
158879002594	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
158879002595	ANP binding site [chemical binding]; other site
158879002596	Substrate Binding Site II [chemical binding]; other site
158879002597	Substrate Binding Site I [chemical binding]; other site
158879002598	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
158879002599	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
158879002600	active site
158879002601	dimer interface [polypeptide binding]; other site
158879002602	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
158879002603	dimer interface [polypeptide binding]; other site
158879002604	active site
158879002605	Uncharacterized conserved protein [Function unknown]; Region: COG0398
158879002606	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
158879002607	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
158879002608	Catalytic site [active]
158879002609	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
158879002610	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
158879002611	Catalytic site [active]
158879002612	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
158879002613	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
158879002614	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
158879002615	Part of AAA domain; Region: AAA_19; pfam13245
158879002616	Family description; Region: UvrD_C_2; pfam13538
158879002617	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
158879002618	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
158879002619	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
158879002620	hypothetical protein; Provisional; Region: PRK13673
158879002621	coenzyme A disulfide reductase; Provisional; Region: PRK13512
158879002622	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
158879002623	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
158879002624	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
158879002625	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
158879002626	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879002627	active site
158879002628	motif I; other site
158879002629	motif II; other site
158879002630	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879002631	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
158879002632	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
158879002633	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
158879002634	catalytic triad [active]
158879002635	catalytic triad [active]
158879002636	oxyanion hole [active]
158879002637	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
158879002638	Clp amino terminal domain; Region: Clp_N; pfam02861
158879002639	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879002640	Walker A motif; other site
158879002641	ATP binding site [chemical binding]; other site
158879002642	Walker B motif; other site
158879002643	arginine finger; other site
158879002644	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
158879002645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879002646	Walker A motif; other site
158879002647	ATP binding site [chemical binding]; other site
158879002648	Walker B motif; other site
158879002649	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
158879002650	Transcriptional regulator [Transcription]; Region: LysR; COG0583
158879002651	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
158879002652	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
158879002653	dimerization interface [polypeptide binding]; other site
158879002654	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
158879002655	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
158879002656	active site
158879002657	catalytic residues [active]
158879002658	metal binding site [ion binding]; metal-binding site
158879002659	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
158879002660	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
158879002661	substrate binding site [chemical binding]; other site
158879002662	MAP domain; Region: MAP; pfam03642
158879002663	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
158879002664	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
158879002665	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
158879002666	dimer interface [polypeptide binding]; other site
158879002667	active site
158879002668	CoA binding pocket [chemical binding]; other site
158879002669	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
158879002670	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
158879002671	dimer interface [polypeptide binding]; other site
158879002672	active site
158879002673	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
158879002674	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
158879002675	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879002676	dimer interface [polypeptide binding]; other site
158879002677	conserved gate region; other site
158879002678	putative PBP binding loops; other site
158879002679	ABC-ATPase subunit interface; other site
158879002680	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
158879002681	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879002682	dimer interface [polypeptide binding]; other site
158879002683	conserved gate region; other site
158879002684	putative PBP binding loops; other site
158879002685	ABC-ATPase subunit interface; other site
158879002686	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
158879002687	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
158879002688	Walker A/P-loop; other site
158879002689	ATP binding site [chemical binding]; other site
158879002690	Q-loop/lid; other site
158879002691	ABC transporter signature motif; other site
158879002692	Walker B; other site
158879002693	D-loop; other site
158879002694	H-loop/switch region; other site
158879002695	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
158879002696	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
158879002697	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
158879002698	Walker A/P-loop; other site
158879002699	ATP binding site [chemical binding]; other site
158879002700	Q-loop/lid; other site
158879002701	ABC transporter signature motif; other site
158879002702	Walker B; other site
158879002703	D-loop; other site
158879002704	H-loop/switch region; other site
158879002705	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
158879002706	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
158879002707	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
158879002708	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
158879002709	peptide binding site [polypeptide binding]; other site
158879002710	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
158879002711	The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510
158879002712	peptide binding site [polypeptide binding]; other site
158879002713	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
158879002714	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
158879002715	Walker A/P-loop; other site
158879002716	ATP binding site [chemical binding]; other site
158879002717	Q-loop/lid; other site
158879002718	ABC transporter signature motif; other site
158879002719	Walker B; other site
158879002720	D-loop; other site
158879002721	H-loop/switch region; other site
158879002722	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
158879002723	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
158879002724	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
158879002725	Walker A/P-loop; other site
158879002726	ATP binding site [chemical binding]; other site
158879002727	Q-loop/lid; other site
158879002728	ABC transporter signature motif; other site
158879002729	Walker B; other site
158879002730	D-loop; other site
158879002731	H-loop/switch region; other site
158879002732	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
158879002733	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
158879002734	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879002735	dimer interface [polypeptide binding]; other site
158879002736	conserved gate region; other site
158879002737	putative PBP binding loops; other site
158879002738	ABC-ATPase subunit interface; other site
158879002739	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
158879002740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879002741	dimer interface [polypeptide binding]; other site
158879002742	conserved gate region; other site
158879002743	putative PBP binding loops; other site
158879002744	ABC-ATPase subunit interface; other site
158879002745	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
158879002746	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
158879002747	active site
158879002748	HIGH motif; other site
158879002749	dimer interface [polypeptide binding]; other site
158879002750	KMSKS motif; other site
158879002751	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
158879002752	ArsC family; Region: ArsC; pfam03960
158879002753	putative catalytic residues [active]
158879002754	thiol/disulfide switch; other site
158879002755	adaptor protein; Provisional; Region: PRK02315
158879002756	Competence protein CoiA-like family, contains a predicted nuclease    domain [General function prediction only]; Region: CoiA; COG4469
158879002757	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
158879002758	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
158879002759	active site
158879002760	Zn binding site [ion binding]; other site
158879002761	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
158879002762	Thioredoxin; Region: Thioredoxin_5; pfam13743
158879002763	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
158879002764	apolar tunnel; other site
158879002765	heme binding site [chemical binding]; other site
158879002766	dimerization interface [polypeptide binding]; other site
158879002767	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
158879002768	putative active site [active]
158879002769	putative metal binding residues [ion binding]; other site
158879002770	signature motif; other site
158879002771	putative triphosphate binding site [ion binding]; other site
158879002772	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
158879002773	synthetase active site [active]
158879002774	NTP binding site [chemical binding]; other site
158879002775	metal binding site [ion binding]; metal-binding site
158879002776	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
158879002777	ATP-NAD kinase; Region: NAD_kinase; pfam01513
158879002778	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
158879002779	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
158879002780	active site
158879002781	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
158879002782	MgtE intracellular N domain; Region: MgtE_N; smart00924
158879002783	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
158879002784	Divalent cation transporter; Region: MgtE; pfam01769
158879002785	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
158879002786	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
158879002787	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
158879002788	TrkA-N domain; Region: TrkA_N; pfam02254
158879002789	TrkA-C domain; Region: TrkA_C; pfam02080
158879002790	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
158879002791	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
158879002792	NAD binding site [chemical binding]; other site
158879002793	homotetramer interface [polypeptide binding]; other site
158879002794	homodimer interface [polypeptide binding]; other site
158879002795	substrate binding site [chemical binding]; other site
158879002796	active site
158879002797	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
158879002798	Domain of unknown function DUF20; Region: UPF0118; pfam01594
158879002799	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
158879002800	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
158879002801	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
158879002802	Putative esterase; Region: Esterase; pfam00756
158879002803	hypothetical protein; Provisional; Region: PRK13679
158879002804	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
158879002805	Major Facilitator Superfamily; Region: MFS_1; pfam07690
158879002806	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879002807	putative substrate translocation pore; other site
158879002808	diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
158879002809	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
158879002810	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
158879002811	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
158879002812	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
158879002813	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
158879002814	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
158879002815	YueH-like protein; Region: YueH; pfam14166
158879002816	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
158879002817	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
158879002818	G1 box; other site
158879002819	putative GEF interaction site [polypeptide binding]; other site
158879002820	GTP/Mg2+ binding site [chemical binding]; other site
158879002821	Switch I region; other site
158879002822	G2 box; other site
158879002823	G3 box; other site
158879002824	Switch II region; other site
158879002825	G4 box; other site
158879002826	G5 box; other site
158879002827	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
158879002828	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
158879002829	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
158879002830	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
158879002831	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
158879002832	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
158879002833	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
158879002834	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
158879002835	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
158879002836	active site
158879002837	metal binding site [ion binding]; metal-binding site
158879002838	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
158879002839	Genetic competence transcription factor [Transcription]; Region: ComK; COG4903
158879002840	IDEAL domain; Region: IDEAL; pfam08858
158879002841	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
158879002842	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
158879002843	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
158879002844	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
158879002845	CAAX protease self-immunity; Region: Abi; pfam02517
158879002846	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891
158879002847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
158879002848	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
158879002849	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
158879002850	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
158879002851	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
158879002852	Walker A/P-loop; other site
158879002853	ATP binding site [chemical binding]; other site
158879002854	Q-loop/lid; other site
158879002855	ABC transporter signature motif; other site
158879002856	Walker B; other site
158879002857	D-loop; other site
158879002858	H-loop/switch region; other site
158879002859	Predicted membrane protein [Function unknown]; Region: COG2259
158879002860	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
158879002861	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
158879002862	siderophore binding site; other site
158879002863	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
158879002864	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879002865	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
158879002866	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
158879002867	Coenzyme A binding pocket [chemical binding]; other site
158879002868	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
158879002869	UbiA prenyltransferase family; Region: UbiA; pfam01040
158879002870	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
158879002871	isochorismate synthases; Region: isochor_syn; TIGR00543
158879002872	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
158879002873	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
158879002874	dimer interface [polypeptide binding]; other site
158879002875	tetramer interface [polypeptide binding]; other site
158879002876	PYR/PP interface [polypeptide binding]; other site
158879002877	TPP binding site [chemical binding]; other site
158879002878	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
158879002879	TPP-binding site; other site
158879002880	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
158879002881	PGAP1-like protein; Region: PGAP1; pfam07819
158879002882	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
158879002883	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
158879002884	substrate binding site [chemical binding]; other site
158879002885	oxyanion hole (OAH) forming residues; other site
158879002886	trimer interface [polypeptide binding]; other site
158879002887	Staphostatin B; Region: Staphostatin_B; pfam09023
158879002888	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
158879002889	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
158879002890	aminotransferase A; Validated; Region: PRK07683
158879002891	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
158879002892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879002893	homodimer interface [polypeptide binding]; other site
158879002894	catalytic residue [active]
158879002895	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
158879002896	Acyltransferase family; Region: Acyl_transf_3; pfam01757
158879002897	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
158879002898	MarR family; Region: MarR; pfam01047
158879002899	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
158879002900	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
158879002901	amidase catalytic site [active]
158879002902	Zn binding residues [ion binding]; other site
158879002903	substrate binding site [chemical binding]; other site
158879002904	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
158879002905	Lysozyme subfamily 2; Region: LYZ2; smart00047
158879002906	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879002907	Coenzyme A binding pocket [chemical binding]; other site
158879002908	Protein of unknown function (DUF2538); Region: DUF2538; pfam10804
158879002909	Transcriptional regulator [Transcription]; Region: LytR; COG1316
158879002910	Beta-lactamase; Region: Beta-lactamase; pfam00144
158879002911	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
158879002912	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
158879002913	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
158879002914	Subunit I/III interface [polypeptide binding]; other site
158879002915	Subunit III/IV interface [polypeptide binding]; other site
158879002916	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
158879002917	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
158879002918	D-pathway; other site
158879002919	Putative ubiquinol binding site [chemical binding]; other site
158879002920	Low-spin heme (heme b) binding site [chemical binding]; other site
158879002921	Putative water exit pathway; other site
158879002922	Binuclear center (heme o3/CuB) [ion binding]; other site
158879002923	K-pathway; other site
158879002924	Putative proton exit pathway; other site
158879002925	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
158879002926	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
158879002927	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
158879002928	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
158879002929	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175
158879002930	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
158879002931	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
158879002932	homodimer interface [polypeptide binding]; other site
158879002933	NADP binding site [chemical binding]; other site
158879002934	substrate binding site [chemical binding]; other site
158879002935	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
158879002936	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
158879002937	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
158879002938	NAD binding site [chemical binding]; other site
158879002939	ATP-grasp domain; Region: ATP-grasp; pfam02222
158879002940	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
158879002941	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
158879002942	ATP binding site [chemical binding]; other site
158879002943	active site
158879002944	substrate binding site [chemical binding]; other site
158879002945	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828
158879002946	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
158879002947	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
158879002948	putative active site [active]
158879002949	catalytic triad [active]
158879002950	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
158879002951	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
158879002952	dimerization interface [polypeptide binding]; other site
158879002953	ATP binding site [chemical binding]; other site
158879002954	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
158879002955	dimerization interface [polypeptide binding]; other site
158879002956	ATP binding site [chemical binding]; other site
158879002957	amidophosphoribosyltransferase; Provisional; Region: PRK07272
158879002958	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
158879002959	active site
158879002960	tetramer interface [polypeptide binding]; other site
158879002961	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
158879002962	active site
158879002963	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
158879002964	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
158879002965	dimerization interface [polypeptide binding]; other site
158879002966	putative ATP binding site [chemical binding]; other site
158879002967	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
158879002968	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
158879002969	active site
158879002970	substrate binding site [chemical binding]; other site
158879002971	cosubstrate binding site; other site
158879002972	catalytic site [active]
158879002973	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
158879002974	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
158879002975	purine monophosphate binding site [chemical binding]; other site
158879002976	dimer interface [polypeptide binding]; other site
158879002977	putative catalytic residues [active]
158879002978	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
158879002979	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
158879002980	phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790
158879002981	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
158879002982	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
158879002983	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
158879002984	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
158879002985	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
158879002986	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
158879002987	Walker A/P-loop; other site
158879002988	ATP binding site [chemical binding]; other site
158879002989	Q-loop/lid; other site
158879002990	ABC transporter signature motif; other site
158879002991	Walker B; other site
158879002992	D-loop; other site
158879002993	H-loop/switch region; other site
158879002994	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
158879002995	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
158879002996	Walker A/P-loop; other site
158879002997	ATP binding site [chemical binding]; other site
158879002998	Q-loop/lid; other site
158879002999	ABC transporter signature motif; other site
158879003000	Walker B; other site
158879003001	D-loop; other site
158879003002	H-loop/switch region; other site
158879003003	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
158879003004	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
158879003005	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
158879003006	putative RNA binding site [nucleotide binding]; other site
158879003007	Methyltransferase domain; Region: Methyltransf_26; pfam13659
158879003008	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
158879003009	dimerization domain swap beta strand [polypeptide binding]; other site
158879003010	regulatory protein interface [polypeptide binding]; other site
158879003011	active site
158879003012	regulatory phosphorylation site [posttranslational modification]; other site
158879003013	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
158879003014	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
158879003015	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
158879003016	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
158879003017	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
158879003018	catalytic residues [active]
158879003019	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
158879003020	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
158879003021	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
158879003022	TrkA-N domain; Region: TrkA_N; pfam02254
158879003023	TrkA-C domain; Region: TrkA_C; pfam02080
158879003024	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
158879003025	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
158879003026	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
158879003027	hypothetical protein; Provisional; Region: PRK13667
158879003028	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
158879003029	active site
158879003030	catalytic residues [active]
158879003031	metal binding site [ion binding]; metal-binding site
158879003032	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
158879003033	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
158879003034	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
158879003035	TPP-binding site [chemical binding]; other site
158879003036	tetramer interface [polypeptide binding]; other site
158879003037	heterodimer interface [polypeptide binding]; other site
158879003038	phosphorylation loop region [posttranslational modification]
158879003039	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
158879003040	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
158879003041	alpha subunit interface [polypeptide binding]; other site
158879003042	TPP binding site [chemical binding]; other site
158879003043	heterodimer interface [polypeptide binding]; other site
158879003044	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
158879003045	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
158879003046	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
158879003047	E3 interaction surface; other site
158879003048	lipoyl attachment site [posttranslational modification]; other site
158879003049	e3 binding domain; Region: E3_binding; pfam02817
158879003050	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
158879003051	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
158879003052	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
158879003053	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
158879003054	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
158879003055	hypothetical protein; Provisional; Region: PRK04387
158879003056	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
158879003057	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
158879003058	non-specific DNA binding site [nucleotide binding]; other site
158879003059	salt bridge; other site
158879003060	sequence-specific DNA binding site [nucleotide binding]; other site
158879003061	Cupin domain; Region: Cupin_2; pfam07883
158879003062	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
158879003063	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
158879003064	Walker A/P-loop; other site
158879003065	ATP binding site [chemical binding]; other site
158879003066	Q-loop/lid; other site
158879003067	ABC transporter signature motif; other site
158879003068	Walker B; other site
158879003069	D-loop; other site
158879003070	H-loop/switch region; other site
158879003071	TOBE domain; Region: TOBE_2; pfam08402
158879003072	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879003073	putative PBP binding loops; other site
158879003074	dimer interface [polypeptide binding]; other site
158879003075	ABC-ATPase subunit interface; other site
158879003076	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
158879003077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879003078	dimer interface [polypeptide binding]; other site
158879003079	conserved gate region; other site
158879003080	putative PBP binding loops; other site
158879003081	ABC-ATPase subunit interface; other site
158879003082	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
158879003083	Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955
158879003084	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
158879003085	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
158879003086	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
158879003087	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
158879003088	manganese transport protein MntH; Reviewed; Region: PRK00701
158879003089	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
158879003090	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
158879003091	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
158879003092	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
158879003093	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
158879003094	active site
158879003095	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
158879003096	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
158879003097	G1 box; other site
158879003098	putative GEF interaction site [polypeptide binding]; other site
158879003099	GTP/Mg2+ binding site [chemical binding]; other site
158879003100	Switch I region; other site
158879003101	G2 box; other site
158879003102	G3 box; other site
158879003103	Switch II region; other site
158879003104	G4 box; other site
158879003105	G5 box; other site
158879003106	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
158879003107	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
158879003108	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
158879003109	hypothetical protein; Provisional; Region: PRK13666
158879003110	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
158879003111	pyruvate carboxylase; Reviewed; Region: PRK12999
158879003112	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
158879003113	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
158879003114	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
158879003115	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
158879003116	active site
158879003117	catalytic residues [active]
158879003118	metal binding site [ion binding]; metal-binding site
158879003119	homodimer binding site [polypeptide binding]; other site
158879003120	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
158879003121	carboxyltransferase (CT) interaction site; other site
158879003122	biotinylation site [posttranslational modification]; other site
158879003123	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
158879003124	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
158879003125	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
158879003126	UbiA prenyltransferase family; Region: UbiA; pfam01040
158879003127	Predicted membrane protein [Function unknown]; Region: COG2322
158879003128	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
158879003129	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
158879003130	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
158879003131	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
158879003132	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
158879003133	putative active site [active]
158879003134	catalytic site [active]
158879003135	putative metal binding site [ion binding]; other site
158879003136	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471
158879003137	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
158879003138	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879003139	S-adenosylmethionine binding site [chemical binding]; other site
158879003140	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
158879003141	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
158879003142	active site
158879003143	(T/H)XGH motif; other site
158879003144	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
158879003145	hypothetical protein; Provisional; Region: PRK13670
158879003146	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
158879003147	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
158879003148	heme uptake protein IsdB; Region: IsdB; TIGR03657
158879003149	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
158879003150	NEAr Transporter domain; Region: NEAT; smart00725
158879003151	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
158879003152	heme-binding site [chemical binding]; other site
158879003153	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
158879003154	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
158879003155	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
158879003156	heme-binding site [chemical binding]; other site
158879003157	heme uptake protein IsdC; Region: IsdC; TIGR03656
158879003158	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
158879003159	heme-binding site [chemical binding]; other site
158879003160	sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068
158879003161	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
158879003162	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
158879003163	intersubunit interface [polypeptide binding]; other site
158879003164	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
158879003165	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
158879003166	ABC-ATPase subunit  interface; other site
158879003167	dimer interface [polypeptide binding]; other site
158879003168	putative PBP binding regions; other site
158879003169	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
158879003170	active site
158879003171	catalytic site [active]
158879003172	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312
158879003173	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
158879003174	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
158879003175	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
158879003176	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
158879003177	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
158879003178	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
158879003179	dimer interface [polypeptide binding]; other site
158879003180	motif 1; other site
158879003181	active site
158879003182	motif 2; other site
158879003183	motif 3; other site
158879003184	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
158879003185	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
158879003186	putative tRNA-binding site [nucleotide binding]; other site
158879003187	B3/4 domain; Region: B3_4; pfam03483
158879003188	tRNA synthetase B5 domain; Region: B5; smart00874
158879003189	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
158879003190	dimer interface [polypeptide binding]; other site
158879003191	motif 1; other site
158879003192	motif 3; other site
158879003193	motif 2; other site
158879003194	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
158879003195	ribonuclease HIII; Provisional; Region: PRK00996
158879003196	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
158879003197	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
158879003198	RNA/DNA hybrid binding site [nucleotide binding]; other site
158879003199	active site
158879003200	Cell division protein ZapA; Region: ZapA; cl01146
158879003201	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
158879003202	Colicin V production protein; Region: Colicin_V; pfam02674
158879003203	hypothetical protein; Provisional; Region: PRK08609
158879003204	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
158879003205	active site
158879003206	primer binding site [nucleotide binding]; other site
158879003207	NTP  binding site [chemical binding]; other site
158879003208	metal binding triad [ion binding]; metal-binding site
158879003209	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
158879003210	active site
158879003211	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
158879003212	MutS domain III; Region: MutS_III; pfam05192
158879003213	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
158879003214	Walker A/P-loop; other site
158879003215	ATP binding site [chemical binding]; other site
158879003216	Q-loop/lid; other site
158879003217	ABC transporter signature motif; other site
158879003218	Walker B; other site
158879003219	D-loop; other site
158879003220	H-loop/switch region; other site
158879003221	Smr domain; Region: Smr; pfam01713
158879003222	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
158879003223	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
158879003224	catalytic residues [active]
158879003225	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
158879003226	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
158879003227	GIY-YIG motif/motif A; other site
158879003228	active site
158879003229	catalytic site [active]
158879003230	putative DNA binding site [nucleotide binding]; other site
158879003231	metal binding site [ion binding]; metal-binding site
158879003232	UvrB/uvrC motif; Region: UVR; pfam02151
158879003233	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
158879003234	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
158879003235	putative Iron-sulfur protein interface [polypeptide binding]; other site
158879003236	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
158879003237	proximal heme binding site [chemical binding]; other site
158879003238	distal heme binding site [chemical binding]; other site
158879003239	putative dimer interface [polypeptide binding]; other site
158879003240	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
158879003241	L-aspartate oxidase; Provisional; Region: PRK06175
158879003242	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
158879003243	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
158879003244	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
158879003245	glutamate racemase; Provisional; Region: PRK00865
158879003246	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
158879003247	active site
158879003248	dimerization interface [polypeptide binding]; other site
158879003249	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
158879003250	active site
158879003251	metal binding site [ion binding]; metal-binding site
158879003252	homotetramer interface [polypeptide binding]; other site
158879003253	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
158879003254	formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033
158879003255	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
158879003256	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
158879003257	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
158879003258	Transposase; Region: DDE_Tnp_ISL3; pfam01610
158879003259	beta-channel forming cytolysin; Region: hlyII; TIGR01002
158879003260	superantigen-like protein; Reviewed; Region: PRK13350
158879003261	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879003262	superantigen-like protein; Reviewed; Region: PRK13349
158879003263	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879003264	superantigen-like protein; Reviewed; Region: PRK13043
158879003265	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879003266	ornithine carbamoyltransferase; Provisional; Region: PRK04284
158879003267	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
158879003268	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
158879003269	carbamate kinase; Reviewed; Region: PRK12686
158879003270	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
158879003271	putative substrate binding site [chemical binding]; other site
158879003272	nucleotide binding site [chemical binding]; other site
158879003273	nucleotide binding site [chemical binding]; other site
158879003274	homodimer interface [polypeptide binding]; other site
158879003275	Predicted membrane protein [Function unknown]; Region: COG1288
158879003276	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
158879003277	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
158879003278	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
158879003279	gating phenylalanine in ion channel; other site
158879003280	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
158879003281	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879003282	motif II; other site
158879003283	hypothetical protein; Provisional; Region: PRK13688
158879003284	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
158879003285	Coenzyme A binding pocket [chemical binding]; other site
158879003286	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
158879003287	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
158879003288	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
158879003289	MraZ protein; Region: MraZ; pfam02381
158879003290	MraZ protein; Region: MraZ; pfam02381
158879003291	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
158879003292	MraW methylase family; Region: Methyltransf_5; pfam01795
158879003293	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
158879003294	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
158879003295	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
158879003296	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
158879003297	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
158879003298	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
158879003299	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
158879003300	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
158879003301	Mg++ binding site [ion binding]; other site
158879003302	putative catalytic motif [active]
158879003303	putative substrate binding site [chemical binding]; other site
158879003304	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
158879003305	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
158879003306	NAD binding site [chemical binding]; other site
158879003307	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
158879003308	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
158879003309	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
158879003310	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
158879003311	Cell division protein FtsQ; Region: FtsQ; pfam03799
158879003312	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
158879003313	Cell division protein FtsA; Region: FtsA; smart00842
158879003314	Cell division protein FtsA; Region: FtsA; pfam14450
158879003315	cell division protein FtsZ; Validated; Region: PRK09330
158879003316	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
158879003317	nucleotide binding site [chemical binding]; other site
158879003318	SulA interaction site; other site
158879003319	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
158879003320	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
158879003321	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
158879003322	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
158879003323	catalytic residue [active]
158879003324	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
158879003325	YGGT family; Region: YGGT; pfam02325
158879003326	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
158879003327	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
158879003328	RNA binding surface [nucleotide binding]; other site
158879003329	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
158879003330	DivIVA domain; Region: DivI1A_domain; TIGR03544
158879003331	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
158879003332	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
158879003333	HIGH motif; other site
158879003334	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
158879003335	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
158879003336	active site
158879003337	KMSKS motif; other site
158879003338	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
158879003339	tRNA binding surface [nucleotide binding]; other site
158879003340	anticodon binding site; other site
158879003341	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
158879003342	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
158879003343	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
158879003344	active site
158879003345	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
158879003346	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
158879003347	lipoprotein signal peptidase; Provisional; Region: PRK14787
158879003348	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
158879003349	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
158879003350	RNA binding surface [nucleotide binding]; other site
158879003351	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
158879003352	active site
158879003353	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
158879003354	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
158879003355	uracil transporter; Provisional; Region: PRK10720
158879003356	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
158879003357	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
158879003358	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
158879003359	dihydroorotase; Validated; Region: pyrC; PRK09357
158879003360	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
158879003361	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
158879003362	active site
158879003363	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
158879003364	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
158879003365	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
158879003366	catalytic site [active]
158879003367	subunit interface [polypeptide binding]; other site
158879003368	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
158879003369	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
158879003370	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
158879003371	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
158879003372	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
158879003373	ATP-grasp domain; Region: ATP-grasp_4; cl17255
158879003374	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
158879003375	IMP binding site; other site
158879003376	dimer interface [polypeptide binding]; other site
158879003377	interdomain contacts; other site
158879003378	partial ornithine binding site; other site
158879003379	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
158879003380	active site
158879003381	dimer interface [polypeptide binding]; other site
158879003382	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
158879003383	active site
158879003384	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
158879003385	dimer interface [polypeptide binding]; other site
158879003386	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
158879003387	Domain of unknown function (DUF814); Region: DUF814; pfam05670
158879003388	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
158879003389	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
158879003390	catalytic site [active]
158879003391	G-X2-G-X-G-K; other site
158879003392	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
158879003393	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
158879003394	Flavoprotein; Region: Flavoprotein; pfam02441
158879003395	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
158879003396	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
158879003397	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
158879003398	ATP binding site [chemical binding]; other site
158879003399	putative Mg++ binding site [ion binding]; other site
158879003400	helicase superfamily c-terminal domain; Region: HELICc; smart00490
158879003401	nucleotide binding region [chemical binding]; other site
158879003402	ATP-binding site [chemical binding]; other site
158879003403	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
158879003404	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
158879003405	active site
158879003406	catalytic residues [active]
158879003407	metal binding site [ion binding]; metal-binding site
158879003408	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
158879003409	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
158879003410	putative active site [active]
158879003411	substrate binding site [chemical binding]; other site
158879003412	putative cosubstrate binding site; other site
158879003413	catalytic site [active]
158879003414	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
158879003415	substrate binding site [chemical binding]; other site
158879003416	16S rRNA methyltransferase B; Provisional; Region: PRK14902
158879003417	NusB family; Region: NusB; pfam01029
158879003418	putative RNA binding site [nucleotide binding]; other site
158879003419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879003420	S-adenosylmethionine binding site [chemical binding]; other site
158879003421	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
158879003422	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
158879003423	FeS/SAM binding site; other site
158879003424	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
158879003425	Protein phosphatase 2C; Region: PP2C; pfam00481
158879003426	active site
158879003427	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
158879003428	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
158879003429	active site
158879003430	ATP binding site [chemical binding]; other site
158879003431	substrate binding site [chemical binding]; other site
158879003432	activation loop (A-loop); other site
158879003433	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
158879003434	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
158879003435	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
158879003436	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
158879003437	Predicted GTPases [General function prediction only]; Region: COG1162
158879003438	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
158879003439	RNA binding site [nucleotide binding]; other site
158879003440	homodimer interface [polypeptide binding]; other site
158879003441	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
158879003442	GTPase/Zn-binding domain interface [polypeptide binding]; other site
158879003443	GTP/Mg2+ binding site [chemical binding]; other site
158879003444	G4 box; other site
158879003445	G5 box; other site
158879003446	G1 box; other site
158879003447	Switch I region; other site
158879003448	G2 box; other site
158879003449	G3 box; other site
158879003450	Switch II region; other site
158879003451	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
158879003452	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
158879003453	substrate binding site [chemical binding]; other site
158879003454	hexamer interface [polypeptide binding]; other site
158879003455	metal binding site [ion binding]; metal-binding site
158879003456	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
158879003457	Thiamine pyrophosphokinase; Region: TPK; cd07995
158879003458	active site
158879003459	dimerization interface [polypeptide binding]; other site
158879003460	thiamine binding site [chemical binding]; other site
158879003461	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
158879003462	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
158879003463	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
158879003464	DAK2 domain; Region: Dak2; pfam02734
158879003465	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
158879003466	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
158879003467	generic binding surface II; other site
158879003468	ssDNA binding site; other site
158879003469	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
158879003470	ATP binding site [chemical binding]; other site
158879003471	putative Mg++ binding site [ion binding]; other site
158879003472	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
158879003473	nucleotide binding region [chemical binding]; other site
158879003474	ATP-binding site [chemical binding]; other site
158879003475	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
158879003476	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
158879003477	active site 2 [active]
158879003478	active site 1 [active]
158879003479	putative phosphate acyltransferase; Provisional; Region: PRK05331
158879003480	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
158879003481	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
158879003482	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
158879003483	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
158879003484	NAD(P) binding site [chemical binding]; other site
158879003485	homotetramer interface [polypeptide binding]; other site
158879003486	homodimer interface [polypeptide binding]; other site
158879003487	active site
158879003488	acyl carrier protein; Provisional; Region: acpP; PRK00982
158879003489	ribonuclease III; Reviewed; Region: rnc; PRK00102
158879003490	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
158879003491	dimerization interface [polypeptide binding]; other site
158879003492	active site
158879003493	metal binding site [ion binding]; metal-binding site
158879003494	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
158879003495	dsRNA binding site [nucleotide binding]; other site
158879003496	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
158879003497	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
158879003498	Walker A/P-loop; other site
158879003499	ATP binding site [chemical binding]; other site
158879003500	Q-loop/lid; other site
158879003501	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
158879003502	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
158879003503	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
158879003504	ABC transporter signature motif; other site
158879003505	Walker B; other site
158879003506	D-loop; other site
158879003507	H-loop/switch region; other site
158879003508	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
158879003509	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
158879003510	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
158879003511	P loop; other site
158879003512	GTP binding site [chemical binding]; other site
158879003513	putative DNA-binding protein; Validated; Region: PRK00118
158879003514	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
158879003515	signal recognition particle protein; Provisional; Region: PRK10867
158879003516	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
158879003517	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
158879003518	P loop; other site
158879003519	GTP binding site [chemical binding]; other site
158879003520	Signal peptide binding domain; Region: SRP_SPB; pfam02978
158879003521	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
158879003522	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
158879003523	RimM N-terminal domain; Region: RimM; pfam01782
158879003524	PRC-barrel domain; Region: PRC; pfam05239
158879003525	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
158879003526	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
158879003527	Predicted membrane protein [Function unknown]; Region: COG4485
158879003528	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
158879003529	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
158879003530	GTP/Mg2+ binding site [chemical binding]; other site
158879003531	G4 box; other site
158879003532	G5 box; other site
158879003533	G1 box; other site
158879003534	Switch I region; other site
158879003535	G2 box; other site
158879003536	G3 box; other site
158879003537	Switch II region; other site
158879003538	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
158879003539	RNA/DNA hybrid binding site [nucleotide binding]; other site
158879003540	active site
158879003541	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
158879003542	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
158879003543	CoA-ligase; Region: Ligase_CoA; pfam00549
158879003544	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
158879003545	CoA binding domain; Region: CoA_binding; pfam02629
158879003546	CoA-ligase; Region: Ligase_CoA; pfam00549
158879003547	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
158879003548	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
158879003549	CHAP domain; Region: CHAP; pfam05257
158879003550	FemAB family; Region: FemAB; pfam02388
158879003551	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
158879003552	DNA protecting protein DprA; Region: dprA; TIGR00732
158879003553	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
158879003554	DNA topoisomerase I; Validated; Region: PRK05582
158879003555	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
158879003556	active site
158879003557	interdomain interaction site; other site
158879003558	putative metal-binding site [ion binding]; other site
158879003559	nucleotide binding site [chemical binding]; other site
158879003560	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
158879003561	domain I; other site
158879003562	DNA binding groove [nucleotide binding]
158879003563	phosphate binding site [ion binding]; other site
158879003564	domain II; other site
158879003565	domain III; other site
158879003566	nucleotide binding site [chemical binding]; other site
158879003567	catalytic site [active]
158879003568	domain IV; other site
158879003569	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
158879003570	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
158879003571	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
158879003572	Glucose inhibited division protein A; Region: GIDA; pfam01134
158879003573	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
158879003574	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
158879003575	active site
158879003576	DNA binding site [nucleotide binding]
158879003577	Int/Topo IB signature motif; other site
158879003578	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
158879003579	active site
158879003580	HslU subunit interaction site [polypeptide binding]; other site
158879003581	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
158879003582	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879003583	Walker A motif; other site
158879003584	ATP binding site [chemical binding]; other site
158879003585	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
158879003586	Walker B motif; other site
158879003587	arginine finger; other site
158879003588	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
158879003589	transcriptional repressor CodY; Validated; Region: PRK04158
158879003590	CodY GAF-like domain; Region: CodY; pfam06018
158879003591	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
158879003592	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
158879003593	rRNA interaction site [nucleotide binding]; other site
158879003594	S8 interaction site; other site
158879003595	putative laminin-1 binding site; other site
158879003596	elongation factor Ts; Provisional; Region: tsf; PRK09377
158879003597	UBA/TS-N domain; Region: UBA; pfam00627
158879003598	Elongation factor TS; Region: EF_TS; pfam00889
158879003599	Elongation factor TS; Region: EF_TS; pfam00889
158879003600	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
158879003601	putative nucleotide binding site [chemical binding]; other site
158879003602	uridine monophosphate binding site [chemical binding]; other site
158879003603	homohexameric interface [polypeptide binding]; other site
158879003604	ribosome recycling factor; Reviewed; Region: frr; PRK00083
158879003605	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
158879003606	hinge region; other site
158879003607	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
158879003608	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
158879003609	catalytic residue [active]
158879003610	putative FPP diphosphate  binding site; other site
158879003611	putative FPP binding hydrophobic cleft; other site
158879003612	dimer interface [polypeptide binding]; other site
158879003613	putative IPP diphosphate binding site; other site
158879003614	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
158879003615	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
158879003616	RIP metalloprotease RseP; Region: TIGR00054
158879003617	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
158879003618	active site
158879003619	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
158879003620	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
158879003621	protein binding site [polypeptide binding]; other site
158879003622	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
158879003623	putative substrate binding region [chemical binding]; other site
158879003624	prolyl-tRNA synthetase; Provisional; Region: PRK09194
158879003625	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
158879003626	dimer interface [polypeptide binding]; other site
158879003627	motif 1; other site
158879003628	active site
158879003629	motif 2; other site
158879003630	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
158879003631	putative deacylase active site [active]
158879003632	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
158879003633	active site
158879003634	motif 3; other site
158879003635	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
158879003636	anticodon binding site; other site
158879003637	DNA polymerase III PolC; Validated; Region: polC; PRK00448
158879003638	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
158879003639	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
158879003640	generic binding surface II; other site
158879003641	generic binding surface I; other site
158879003642	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
158879003643	active site
158879003644	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
158879003645	active site
158879003646	catalytic site [active]
158879003647	substrate binding site [chemical binding]; other site
158879003648	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
158879003649	ribosome maturation protein RimP; Reviewed; Region: PRK00092
158879003650	Sm and related proteins; Region: Sm_like; cl00259
158879003651	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
158879003652	putative oligomer interface [polypeptide binding]; other site
158879003653	putative RNA binding site [nucleotide binding]; other site
158879003654	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
158879003655	NusA N-terminal domain; Region: NusA_N; pfam08529
158879003656	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
158879003657	RNA binding site [nucleotide binding]; other site
158879003658	homodimer interface [polypeptide binding]; other site
158879003659	NusA-like KH domain; Region: KH_5; pfam13184
158879003660	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
158879003661	G-X-X-G motif; other site
158879003662	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
158879003663	putative RNA binding cleft [nucleotide binding]; other site
158879003664	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
158879003665	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
158879003666	translation initiation factor IF-2; Region: IF-2; TIGR00487
158879003667	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
158879003668	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
158879003669	G1 box; other site
158879003670	putative GEF interaction site [polypeptide binding]; other site
158879003671	GTP/Mg2+ binding site [chemical binding]; other site
158879003672	Switch I region; other site
158879003673	G2 box; other site
158879003674	G3 box; other site
158879003675	Switch II region; other site
158879003676	G4 box; other site
158879003677	G5 box; other site
158879003678	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
158879003679	Translation-initiation factor 2; Region: IF-2; pfam11987
158879003680	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
158879003681	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
158879003682	tRNA pseudouridine synthase B; Provisional; Region: PRK14123
158879003683	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
158879003684	RNA binding site [nucleotide binding]; other site
158879003685	active site
158879003686	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
158879003687	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
158879003688	active site
158879003689	Riboflavin kinase; Region: Flavokinase; smart00904
158879003690	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
158879003691	16S/18S rRNA binding site [nucleotide binding]; other site
158879003692	S13e-L30e interaction site [polypeptide binding]; other site
158879003693	25S rRNA binding site [nucleotide binding]; other site
158879003694	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
158879003695	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
158879003696	RNase E interface [polypeptide binding]; other site
158879003697	trimer interface [polypeptide binding]; other site
158879003698	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
158879003699	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
158879003700	RNase E interface [polypeptide binding]; other site
158879003701	trimer interface [polypeptide binding]; other site
158879003702	active site
158879003703	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
158879003704	putative nucleic acid binding region [nucleotide binding]; other site
158879003705	G-X-X-G motif; other site
158879003706	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
158879003707	RNA binding site [nucleotide binding]; other site
158879003708	domain interface; other site
158879003709	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
158879003710	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
158879003711	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
158879003712	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
158879003713	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
158879003714	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
158879003715	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
158879003716	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
158879003717	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
158879003718	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
158879003719	DNA-binding site [nucleotide binding]; DNA binding site
158879003720	UTRA domain; Region: UTRA; pfam07702
158879003721	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
158879003722	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
158879003723	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
158879003724	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
158879003725	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
158879003726	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
158879003727	classical (c) SDRs; Region: SDR_c; cd05233
158879003728	NAD(P) binding site [chemical binding]; other site
158879003729	active site
158879003730	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
158879003731	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
158879003732	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
158879003733	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
158879003734	non-specific DNA binding site [nucleotide binding]; other site
158879003735	salt bridge; other site
158879003736	sequence-specific DNA binding site [nucleotide binding]; other site
158879003737	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
158879003738	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
158879003739	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
158879003740	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
158879003741	putative MPT binding site; other site
158879003742	recombinase A; Provisional; Region: recA; PRK09354
158879003743	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
158879003744	hexamer interface [polypeptide binding]; other site
158879003745	Walker A motif; other site
158879003746	ATP binding site [chemical binding]; other site
158879003747	Walker B motif; other site
158879003748	phosphodiesterase; Provisional; Region: PRK12704
158879003749	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
158879003750	Zn2+ binding site [ion binding]; other site
158879003751	Mg2+ binding site [ion binding]; other site
158879003752	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
158879003753	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
158879003754	putative active site [active]
158879003755	metal binding site [ion binding]; metal-binding site
158879003756	homodimer binding site [polypeptide binding]; other site
158879003757	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
158879003758	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
158879003759	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
158879003760	dimer interface [polypeptide binding]; other site
158879003761	PYR/PP interface [polypeptide binding]; other site
158879003762	TPP binding site [chemical binding]; other site
158879003763	substrate binding site [chemical binding]; other site
158879003764	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
158879003765	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
158879003766	TPP-binding site [chemical binding]; other site
158879003767	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
158879003768	Uncharacterized conserved protein [Function unknown]; Region: COG0011
158879003769	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
158879003770	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
158879003771	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
158879003772	FeS/SAM binding site; other site
158879003773	TRAM domain; Region: TRAM; pfam01938
158879003774	Predicted membrane protein [Function unknown]; Region: COG4550
158879003775	Predicted membrane protein [Function unknown]; Region: COG4732
158879003776	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
158879003777	MutS domain I; Region: MutS_I; pfam01624
158879003778	MutS domain II; Region: MutS_II; pfam05188
158879003779	MutS domain III; Region: MutS_III; pfam05192
158879003780	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
158879003781	Walker A/P-loop; other site
158879003782	ATP binding site [chemical binding]; other site
158879003783	Q-loop/lid; other site
158879003784	ABC transporter signature motif; other site
158879003785	Walker B; other site
158879003786	D-loop; other site
158879003787	H-loop/switch region; other site
158879003788	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
158879003789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879003790	ATP binding site [chemical binding]; other site
158879003791	Mg2+ binding site [ion binding]; other site
158879003792	G-X-G motif; other site
158879003793	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
158879003794	ATP binding site [chemical binding]; other site
158879003795	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
158879003796	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309
158879003797	similar to hypothetical protein
158879003798	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
158879003799	amphipathic channel; other site
158879003800	Asn-Pro-Ala signature motifs; other site
158879003801	glycerol kinase; Provisional; Region: glpK; PRK00047
158879003802	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
158879003803	N- and C-terminal domain interface [polypeptide binding]; other site
158879003804	active site
158879003805	MgATP binding site [chemical binding]; other site
158879003806	catalytic site [active]
158879003807	metal binding site [ion binding]; metal-binding site
158879003808	glycerol binding site [chemical binding]; other site
158879003809	homotetramer interface [polypeptide binding]; other site
158879003810	homodimer interface [polypeptide binding]; other site
158879003811	FBP binding site [chemical binding]; other site
158879003812	protein IIAGlc interface [polypeptide binding]; other site
158879003813	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
158879003814	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
158879003815	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
158879003816	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
158879003817	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
158879003818	bacterial Hfq-like; Region: Hfq; cd01716
158879003819	hexamer interface [polypeptide binding]; other site
158879003820	Sm1 motif; other site
158879003821	RNA binding site [nucleotide binding]; other site
158879003822	Sm2 motif; other site
158879003823	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
158879003824	catalytic residues [active]
158879003825	dimer interface [polypeptide binding]; other site
158879003826	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
158879003827	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
158879003828	HflX GTPase family; Region: HflX; cd01878
158879003829	G1 box; other site
158879003830	GTP/Mg2+ binding site [chemical binding]; other site
158879003831	Switch I region; other site
158879003832	G2 box; other site
158879003833	G3 box; other site
158879003834	Switch II region; other site
158879003835	G4 box; other site
158879003836	G5 box; other site
158879003837	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
158879003838	Aluminium resistance protein; Region: Alum_res; pfam06838
158879003839	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
158879003840	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
158879003841	DNA binding residues [nucleotide binding]
158879003842	putative dimer interface [polypeptide binding]; other site
158879003843	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
158879003844	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
158879003845	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
158879003846	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
158879003847	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
158879003848	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
158879003849	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
158879003850	catalytic residue [active]
158879003851	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
158879003852	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
158879003853	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
158879003854	putative active site [active]
158879003855	catalytic site [active]
158879003856	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
158879003857	putative active site [active]
158879003858	catalytic site [active]
158879003859	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
158879003860	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
158879003861	Walker A/P-loop; other site
158879003862	ATP binding site [chemical binding]; other site
158879003863	Q-loop/lid; other site
158879003864	ABC transporter signature motif; other site
158879003865	Walker B; other site
158879003866	D-loop; other site
158879003867	H-loop/switch region; other site
158879003868	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
158879003869	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
158879003870	Histidine kinase; Region: HisKA_3; pfam07730
158879003871	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
158879003872	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
158879003873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879003874	active site
158879003875	phosphorylation site [posttranslational modification]
158879003876	intermolecular recognition site; other site
158879003877	dimerization interface [polypeptide binding]; other site
158879003878	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
158879003879	DNA binding residues [nucleotide binding]
158879003880	dimerization interface [polypeptide binding]; other site
158879003881	Staphylococcal nuclease homologues; Region: SNc; smart00318
158879003882	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
158879003883	Catalytic site; other site
158879003884	AAA domain; Region: AAA_11; pfam13086
158879003885	aspartate kinase; Reviewed; Region: PRK09034
158879003886	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
158879003887	putative catalytic residues [active]
158879003888	putative nucleotide binding site [chemical binding]; other site
158879003889	putative aspartate binding site [chemical binding]; other site
158879003890	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
158879003891	allosteric regulatory residue; other site
158879003892	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
158879003893	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
158879003894	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
158879003895	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
158879003896	threonine synthase; Reviewed; Region: PRK06721
158879003897	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
158879003898	homodimer interface [polypeptide binding]; other site
158879003899	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879003900	catalytic residue [active]
158879003901	homoserine kinase; Provisional; Region: PRK01212
158879003902	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
158879003903	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
158879003904	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879003905	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
158879003906	active site
158879003907	motif I; other site
158879003908	motif II; other site
158879003909	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
158879003910	lysine transporter; Provisional; Region: PRK10836
158879003911	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
158879003912	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
158879003913	tetramer interface [polypeptide binding]; other site
158879003914	heme binding pocket [chemical binding]; other site
158879003915	NADPH binding site [chemical binding]; other site
158879003916	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
158879003917	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
158879003918	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
158879003919	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
158879003920	active site
158879003921	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
158879003922	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
158879003923	LexA repressor; Validated; Region: PRK00215
158879003924	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
158879003925	putative DNA binding site [nucleotide binding]; other site
158879003926	putative Zn2+ binding site [ion binding]; other site
158879003927	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
158879003928	Catalytic site [active]
158879003929	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
158879003930	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
158879003931	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
158879003932	TPP-binding site [chemical binding]; other site
158879003933	dimer interface [polypeptide binding]; other site
158879003934	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
158879003935	PYR/PP interface [polypeptide binding]; other site
158879003936	dimer interface [polypeptide binding]; other site
158879003937	TPP binding site [chemical binding]; other site
158879003938	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
158879003939	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
158879003940	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
158879003941	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
158879003942	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
158879003943	active site
158879003944	metal binding site [ion binding]; metal-binding site
158879003945	DNA binding site [nucleotide binding]
158879003946	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
158879003947	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
158879003948	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
158879003949	Walker A/P-loop; other site
158879003950	ATP binding site [chemical binding]; other site
158879003951	Q-loop/lid; other site
158879003952	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
158879003953	ABC transporter signature motif; other site
158879003954	Walker B; other site
158879003955	D-loop; other site
158879003956	H-loop/switch region; other site
158879003957	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
158879003958	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954
158879003959	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
158879003960	aconitate hydratase; Validated; Region: PRK09277
158879003961	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
158879003962	substrate binding site [chemical binding]; other site
158879003963	ligand binding site [chemical binding]; other site
158879003964	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
158879003965	substrate binding site [chemical binding]; other site
158879003966	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
158879003967	active site
158879003968	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
158879003969	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
158879003970	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
158879003971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879003972	ATP binding site [chemical binding]; other site
158879003973	Mg2+ binding site [ion binding]; other site
158879003974	G-X-G motif; other site
158879003975	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
158879003976	anchoring element; other site
158879003977	dimer interface [polypeptide binding]; other site
158879003978	ATP binding site [chemical binding]; other site
158879003979	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
158879003980	active site
158879003981	putative metal-binding site [ion binding]; other site
158879003982	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
158879003983	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
158879003984	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
158879003985	CAP-like domain; other site
158879003986	active site
158879003987	primary dimer interface [polypeptide binding]; other site
158879003988	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
158879003989	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
158879003990	amino acid carrier protein; Region: agcS; TIGR00835
158879003991	CAT RNA binding domain; Region: CAT_RBD; smart01061
158879003992	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
158879003993	PRD domain; Region: PRD; pfam00874
158879003994	PRD domain; Region: PRD; pfam00874
158879003995	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
158879003996	Domain of unknown function DUF20; Region: UPF0118; pfam01594
158879003997	Predicted integral membrane protein [Function unknown]; Region: COG0392
158879003998	Uncharacterized conserved protein [Function unknown]; Region: COG2898
158879003999	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
158879004000	methionine sulfoxide reductase A; Provisional; Region: PRK14054
158879004001	Transcriptional regulator [Transcription]; Region: LytR; COG1316
158879004002	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
158879004003	active site 1 [active]
158879004004	dimer interface [polypeptide binding]; other site
158879004005	hexamer interface [polypeptide binding]; other site
158879004006	active site 2 [active]
158879004007	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
158879004008	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
158879004009	active site
158879004010	DNA binding site [nucleotide binding]
158879004011	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
158879004012	prephenate dehydrogenase; Validated; Region: PRK06545
158879004013	prephenate dehydrogenase; Validated; Region: PRK08507
158879004014	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
158879004015	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
158879004016	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
158879004017	putative oligomer interface [polypeptide binding]; other site
158879004018	putative active site [active]
158879004019	metal binding site [ion binding]; metal-binding site
158879004020	anthranilate synthase component I; Provisional; Region: PRK13567
158879004021	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
158879004022	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
158879004023	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
158879004024	Glutamine amidotransferase class-I; Region: GATase; pfam00117
158879004025	glutamine binding [chemical binding]; other site
158879004026	catalytic triad [active]
158879004027	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
158879004028	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
158879004029	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
158879004030	active site
158879004031	ribulose/triose binding site [chemical binding]; other site
158879004032	phosphate binding site [ion binding]; other site
158879004033	substrate (anthranilate) binding pocket [chemical binding]; other site
158879004034	product (indole) binding pocket [chemical binding]; other site
158879004035	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
158879004036	active site
158879004037	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
158879004038	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
158879004039	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879004040	catalytic residue [active]
158879004041	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
158879004042	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
158879004043	substrate binding site [chemical binding]; other site
158879004044	active site
158879004045	catalytic residues [active]
158879004046	heterodimer interface [polypeptide binding]; other site
158879004047	FemAB family; Region: FemAB; pfam02388
158879004048	FlxA-like protein; Region: FlxA; pfam14282
158879004049	FemAB family; Region: FemAB; pfam02388
158879004050	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
158879004051	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879004052	active site
158879004053	motif I; other site
158879004054	motif II; other site
158879004055	SWIM zinc finger; Region: SWIM; pfam04434
158879004056	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
158879004057	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
158879004058	Walker A/P-loop; other site
158879004059	ATP binding site [chemical binding]; other site
158879004060	Q-loop/lid; other site
158879004061	ABC transporter signature motif; other site
158879004062	Walker B; other site
158879004063	D-loop; other site
158879004064	H-loop/switch region; other site
158879004065	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
158879004066	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
158879004067	Walker A/P-loop; other site
158879004068	ATP binding site [chemical binding]; other site
158879004069	Q-loop/lid; other site
158879004070	ABC transporter signature motif; other site
158879004071	Walker B; other site
158879004072	D-loop; other site
158879004073	H-loop/switch region; other site
158879004074	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
158879004075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879004076	dimer interface [polypeptide binding]; other site
158879004077	conserved gate region; other site
158879004078	putative PBP binding loops; other site
158879004079	ABC-ATPase subunit interface; other site
158879004080	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
158879004081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879004082	dimer interface [polypeptide binding]; other site
158879004083	conserved gate region; other site
158879004084	putative PBP binding loops; other site
158879004085	ABC-ATPase subunit interface; other site
158879004086	bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726
158879004087	oligoendopeptidase F; Region: pepF; TIGR00181
158879004088	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
158879004089	active site
158879004090	Zn binding site [ion binding]; other site
158879004091	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
158879004092	PhoU domain; Region: PhoU; pfam01895
158879004093	PhoU domain; Region: PhoU; pfam01895
158879004094	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
158879004095	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
158879004096	Walker A/P-loop; other site
158879004097	ATP binding site [chemical binding]; other site
158879004098	Q-loop/lid; other site
158879004099	ABC transporter signature motif; other site
158879004100	Walker B; other site
158879004101	D-loop; other site
158879004102	H-loop/switch region; other site
158879004103	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
158879004104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879004105	dimer interface [polypeptide binding]; other site
158879004106	conserved gate region; other site
158879004107	putative PBP binding loops; other site
158879004108	ABC-ATPase subunit interface; other site
158879004109	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
158879004110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879004111	dimer interface [polypeptide binding]; other site
158879004112	conserved gate region; other site
158879004113	ABC-ATPase subunit interface; other site
158879004114	phosphate binding protein; Region: ptsS_2; TIGR02136
158879004115	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
158879004116	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
158879004117	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
158879004118	S1 domain; Region: S1_2; pfam13509
158879004119	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
158879004120	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
158879004121	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
158879004122	ABC transporter; Region: ABC_tran_2; pfam12848
158879004123	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
158879004124	aspartate kinase; Reviewed; Region: PRK06635
158879004125	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
158879004126	putative nucleotide binding site [chemical binding]; other site
158879004127	putative catalytic residues [active]
158879004128	putative Mg ion binding site [ion binding]; other site
158879004129	putative aspartate binding site [chemical binding]; other site
158879004130	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
158879004131	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
158879004132	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
158879004133	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
158879004134	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
158879004135	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
158879004136	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
158879004137	dimer interface [polypeptide binding]; other site
158879004138	active site
158879004139	catalytic residue [active]
158879004140	dihydrodipicolinate reductase; Provisional; Region: PRK00048
158879004141	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
158879004142	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
158879004143	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
158879004144	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
158879004145	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
158879004146	active site
158879004147	trimer interface [polypeptide binding]; other site
158879004148	substrate binding site [chemical binding]; other site
158879004149	CoA binding site [chemical binding]; other site
158879004150	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
158879004151	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
158879004152	metal binding site [ion binding]; metal-binding site
158879004153	dimer interface [polypeptide binding]; other site
158879004154	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
158879004155	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
158879004156	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
158879004157	catalytic residue [active]
158879004158	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
158879004159	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
158879004160	active site
158879004161	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
158879004162	substrate binding site [chemical binding]; other site
158879004163	catalytic residues [active]
158879004164	dimer interface [polypeptide binding]; other site
158879004165	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
158879004166	DNA-binding site [nucleotide binding]; DNA binding site
158879004167	RNA-binding motif; other site
158879004168	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699
158879004169	acylphosphatase; Provisional; Region: PRK14431
158879004170	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
158879004171	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
158879004172	Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114
158879004173	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
158879004174	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
158879004175	metal ion-dependent adhesion site (MIDAS); other site
158879004176	MoxR-like ATPases [General function prediction only]; Region: COG0714
158879004177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879004178	Walker A motif; other site
158879004179	ATP binding site [chemical binding]; other site
158879004180	Walker B motif; other site
158879004181	arginine finger; other site
158879004182	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
158879004183	active site
158879004184	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
158879004185	active site
158879004186	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
158879004187	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
158879004188	E3 interaction surface; other site
158879004189	lipoyl attachment site [posttranslational modification]; other site
158879004190	e3 binding domain; Region: E3_binding; pfam02817
158879004191	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
158879004192	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
158879004193	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
158879004194	TPP-binding site [chemical binding]; other site
158879004195	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
158879004196	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
158879004197	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
158879004198	HAMP domain; Region: HAMP; pfam00672
158879004199	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
158879004200	dimer interface [polypeptide binding]; other site
158879004201	phosphorylation site [posttranslational modification]
158879004202	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879004203	ATP binding site [chemical binding]; other site
158879004204	Mg2+ binding site [ion binding]; other site
158879004205	G-X-G motif; other site
158879004206	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
158879004207	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
158879004208	DNA binding site [nucleotide binding]
158879004209	Response regulator receiver domain; Region: Response_reg; pfam00072
158879004210	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879004211	active site
158879004212	phosphorylation site [posttranslational modification]
158879004213	intermolecular recognition site; other site
158879004214	dimerization interface [polypeptide binding]; other site
158879004215	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
158879004216	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
158879004217	active site
158879004218	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
158879004219	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
158879004220	active site
158879004221	homodimer interface [polypeptide binding]; other site
158879004222	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879004223	Coenzyme A binding pocket [chemical binding]; other site
158879004224	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
158879004225	C-terminal peptidase (prc); Region: prc; TIGR00225
158879004226	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
158879004227	protein binding site [polypeptide binding]; other site
158879004228	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
158879004229	Catalytic dyad [active]
158879004230	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
158879004231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479
158879004232	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
158879004233	HPr interaction site; other site
158879004234	glycerol kinase (GK) interaction site [polypeptide binding]; other site
158879004235	active site
158879004236	phosphorylation site [posttranslational modification]
158879004237	methionine sulfoxide reductase B; Provisional; Region: PRK00222
158879004238	SelR domain; Region: SelR; pfam01641
158879004239	methionine sulfoxide reductase A; Provisional; Region: PRK13014
158879004240	EDD domain protein, DegV family; Region: DegV; TIGR00762
158879004241	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
158879004242	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
158879004243	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
158879004244	folate binding site [chemical binding]; other site
158879004245	NADP+ binding site [chemical binding]; other site
158879004246	thymidylate synthase; Region: thym_sym; TIGR03284
158879004247	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
158879004248	dimerization interface [polypeptide binding]; other site
158879004249	active site
158879004250	Disulphide isomerase; Region: Disulph_isomer; pfam06491
158879004251	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
158879004252	Virulence factor; Region: Virulence_fact; pfam13769
158879004253	HEAT repeats; Region: HEAT_2; pfam13646
158879004254	HEAT repeat; Region: HEAT; pfam02985
158879004255	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
158879004256	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
158879004257	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
158879004258	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
158879004259	RNA/DNA hybrid binding site [nucleotide binding]; other site
158879004260	active site
158879004261	GA module; Region: GA; smart00844
158879004262	GA module; Region: GA; smart00844
158879004263	GA module; Region: GA; smart00844
158879004264	GA module; Region: GA; smart00844
158879004265	GA module; Region: GA; smart00844
158879004266	GA module; Region: GA; smart00844
158879004267	GA module; Region: GA; smart00844
158879004268	GA module; Region: GA; smart00844
158879004269	GA module; Region: GA; smart00844
158879004270	GA module; Region: GA; smart00844
158879004271	GA module; Region: GA; smart00844
158879004272	GA module; Region: GA; smart00844
158879004273	GA module; Region: GA; smart00844
158879004274	GA module; Region: GA; smart00844
158879004275	GA module; Region: GA; smart00844
158879004276	GA module; Region: GA; smart00844
158879004277	GA module; Region: GA; smart00844
158879004278	GA module; Region: GA; smart00844
158879004279	GA module; Region: GA; pfam01468
158879004280	GA module; Region: GA; smart00844
158879004281	GA module; Region: GA; smart00844
158879004282	GA module; Region: GA; smart00844
158879004283	GA module; Region: GA; smart00844
158879004284	GA module; Region: GA; pfam01468
158879004285	GA module; Region: GA; smart00844
158879004286	GA module; Region: GA; smart00844
158879004287	GA module; Region: GA; smart00844
158879004288	GA module; Region: GA; smart00844
158879004289	GA module; Region: GA; smart00844
158879004290	GA module; Region: GA; smart00844
158879004291	GA module; Region: GA; smart00844
158879004292	GA module; Region: GA; smart00844
158879004293	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
158879004294	GA module; Region: GA; pfam01468
158879004295	GA module; Region: GA; smart00844
158879004296	GA module; Region: GA; smart00844
158879004297	GA module; Region: GA; smart00844
158879004298	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
158879004299	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
158879004300	GA module; Region: GA; smart00844
158879004301	Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554
158879004302	GA module; Region: GA; smart00844
158879004303	GA module; Region: GA; smart00844
158879004304	Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554
158879004305	GA module; Region: GA; smart00844
158879004306	Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554
158879004307	GA module; Region: GA; smart00844
158879004308	Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554
158879004309	GA module; Region: GA; smart00844
158879004310	Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554
158879004311	GA module; Region: GA; smart00844
158879004312	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
158879004313	Amino acid permease; Region: AA_permease_2; pfam13520
158879004314	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
158879004315	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
158879004316	tetramer interface [polypeptide binding]; other site
158879004317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879004318	catalytic residue [active]
158879004319	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
158879004320	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
158879004321	hexamer interface [polypeptide binding]; other site
158879004322	ligand binding site [chemical binding]; other site
158879004323	putative active site [active]
158879004324	NAD(P) binding site [chemical binding]; other site
158879004325	5'-3' exonuclease; Region: 53EXOc; smart00475
158879004326	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
158879004327	active site
158879004328	metal binding site 1 [ion binding]; metal-binding site
158879004329	putative 5' ssDNA interaction site; other site
158879004330	metal binding site 3; metal-binding site
158879004331	metal binding site 2 [ion binding]; metal-binding site
158879004332	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
158879004333	putative DNA binding site [nucleotide binding]; other site
158879004334	putative metal binding site [ion binding]; other site
158879004335	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
158879004336	Dynamin family; Region: Dynamin_N; pfam00350
158879004337	G1 box; other site
158879004338	GTP/Mg2+ binding site [chemical binding]; other site
158879004339	G2 box; other site
158879004340	Switch I region; other site
158879004341	G3 box; other site
158879004342	Switch II region; other site
158879004343	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
158879004344	G4 box; other site
158879004345	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
158879004346	Dynamin family; Region: Dynamin_N; pfam00350
158879004347	G1 box; other site
158879004348	GTP/Mg2+ binding site [chemical binding]; other site
158879004349	G2 box; other site
158879004350	Switch I region; other site
158879004351	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
158879004352	G3 box; other site
158879004353	Switch II region; other site
158879004354	GTP/Mg2+ binding site [chemical binding]; other site
158879004355	G4 box; other site
158879004356	G5 box; other site
158879004357	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
158879004358	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
158879004359	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
158879004360	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
158879004361	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
158879004362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
158879004363	cell division protein GpsB; Provisional; Region: PRK14127
158879004364	DivIVA domain; Region: DivI1A_domain; TIGR03544
158879004365	hypothetical protein; Provisional; Region: PRK13660
158879004366	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
158879004367	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
158879004368	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
158879004369	Transglycosylase; Region: Transgly; pfam00912
158879004370	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
158879004371	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
158879004372	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
158879004373	minor groove reading motif; other site
158879004374	helix-hairpin-helix signature motif; other site
158879004375	substrate binding pocket [chemical binding]; other site
158879004376	active site
158879004377	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
158879004378	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
158879004379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
158879004380	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
158879004381	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
158879004382	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
158879004383	putative dimer interface [polypeptide binding]; other site
158879004384	putative anticodon binding site; other site
158879004385	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
158879004386	homodimer interface [polypeptide binding]; other site
158879004387	motif 1; other site
158879004388	motif 2; other site
158879004389	active site
158879004390	motif 3; other site
158879004391	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
158879004392	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
158879004393	active site
158879004394	catalytic site [active]
158879004395	substrate binding site [chemical binding]; other site
158879004396	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
158879004397	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
158879004398	Biotin operon repressor [Transcription]; Region: BirA; COG1654
158879004399	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
158879004400	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
158879004401	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
158879004402	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
158879004403	active site
158879004404	NTP binding site [chemical binding]; other site
158879004405	metal binding triad [ion binding]; metal-binding site
158879004406	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
158879004407	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
158879004408	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
158879004409	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
158879004410	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
158879004411	homodimer interface [polypeptide binding]; other site
158879004412	metal binding site [ion binding]; metal-binding site
158879004413	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
158879004414	Predicted membrane protein [Function unknown]; Region: COG4347
158879004415	Uncharacterized conserved protein [Function unknown]; Region: COG5582
158879004416	UPF0302 domain; Region: UPF0302; pfam08864
158879004417	A short protein domain of unknown function; Region: IDEAL; smart00914
158879004418	TPR repeat; Region: TPR_11; pfam13414
158879004419	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
158879004420	binding surface
158879004421	TPR motif; other site
158879004422	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
158879004423	TPR motif; other site
158879004424	binding surface
158879004425	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
158879004426	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
158879004427	hinge; other site
158879004428	active site
158879004429	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
158879004430	active site
158879004431	NAD binding site [chemical binding]; other site
158879004432	metal binding site [ion binding]; metal-binding site
158879004433	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
158879004434	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
158879004435	Tetramer interface [polypeptide binding]; other site
158879004436	active site
158879004437	FMN-binding site [chemical binding]; other site
158879004438	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
158879004439	active site
158879004440	multimer interface [polypeptide binding]; other site
158879004441	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
158879004442	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
158879004443	substrate binding pocket [chemical binding]; other site
158879004444	chain length determination region; other site
158879004445	substrate-Mg2+ binding site; other site
158879004446	catalytic residues [active]
158879004447	aspartate-rich region 1; other site
158879004448	active site lid residues [active]
158879004449	aspartate-rich region 2; other site
158879004450	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
158879004451	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879004452	S-adenosylmethionine binding site [chemical binding]; other site
158879004453	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
158879004454	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
158879004455	IHF dimer interface [polypeptide binding]; other site
158879004456	IHF - DNA interface [nucleotide binding]; other site
158879004457	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
158879004458	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
158879004459	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
158879004460	GTP-binding protein Der; Reviewed; Region: PRK00093
158879004461	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
158879004462	G1 box; other site
158879004463	GTP/Mg2+ binding site [chemical binding]; other site
158879004464	Switch I region; other site
158879004465	G2 box; other site
158879004466	Switch II region; other site
158879004467	G3 box; other site
158879004468	G4 box; other site
158879004469	G5 box; other site
158879004470	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
158879004471	G1 box; other site
158879004472	GTP/Mg2+ binding site [chemical binding]; other site
158879004473	Switch I region; other site
158879004474	G2 box; other site
158879004475	G3 box; other site
158879004476	Switch II region; other site
158879004477	G4 box; other site
158879004478	G5 box; other site
158879004479	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
158879004480	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
158879004481	RNA binding site [nucleotide binding]; other site
158879004482	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
158879004483	RNA binding site [nucleotide binding]; other site
158879004484	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
158879004485	RNA binding site [nucleotide binding]; other site
158879004486	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
158879004487	RNA binding site [nucleotide binding]; other site
158879004488	similar to hypothetical protein
158879004489	cytidylate kinase; Provisional; Region: cmk; PRK00023
158879004490	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
158879004491	CMP-binding site; other site
158879004492	The sites determining sugar specificity; other site
158879004493	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
158879004494	active site
158879004495	homotetramer interface [polypeptide binding]; other site
158879004496	homodimer interface [polypeptide binding]; other site
158879004497	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
158879004498	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
158879004499	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
158879004500	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
158879004501	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
158879004502	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
158879004503	ATP binding site [chemical binding]; other site
158879004504	putative Mg++ binding site [ion binding]; other site
158879004505	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
158879004506	nucleotide binding region [chemical binding]; other site
158879004507	ATP-binding site [chemical binding]; other site
158879004508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
158879004509	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
158879004510	Predicted membrane protein [Function unknown]; Region: COG3601
158879004511	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
158879004512	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
158879004513	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
158879004514	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
158879004515	V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496
158879004516	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
158879004517	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
158879004518	dimerization interface [polypeptide binding]; other site
158879004519	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
158879004520	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
158879004521	dimer interface [polypeptide binding]; other site
158879004522	phosphorylation site [posttranslational modification]
158879004523	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879004524	ATP binding site [chemical binding]; other site
158879004525	Mg2+ binding site [ion binding]; other site
158879004526	G-X-G motif; other site
158879004527	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
158879004528	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879004529	active site
158879004530	phosphorylation site [posttranslational modification]
158879004531	intermolecular recognition site; other site
158879004532	dimerization interface [polypeptide binding]; other site
158879004533	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
158879004534	DNA binding site [nucleotide binding]
158879004535	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
158879004536	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
158879004537	RNA binding surface [nucleotide binding]; other site
158879004538	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
158879004539	active site
158879004540	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
158879004541	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
158879004542	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
158879004543	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
158879004544	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
158879004545	active site
158879004546	Int/Topo IB signature motif; other site
158879004547	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
158879004548	metal binding site 2 [ion binding]; metal-binding site
158879004549	putative DNA binding helix; other site
158879004550	metal binding site 1 [ion binding]; metal-binding site
158879004551	dimer interface [polypeptide binding]; other site
158879004552	structural Zn2+ binding site [ion binding]; other site
158879004553	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
158879004554	dimer interface [polypeptide binding]; other site
158879004555	ADP-ribose binding site [chemical binding]; other site
158879004556	active site
158879004557	nudix motif; other site
158879004558	metal binding site [ion binding]; metal-binding site
158879004559	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
158879004560	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
158879004561	active site
158879004562	catalytic tetrad [active]
158879004563	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
158879004564	classical (c) SDRs; Region: SDR_c; cd05233
158879004565	NAD(P) binding site [chemical binding]; other site
158879004566	active site
158879004567	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
158879004568	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
158879004569	ribonuclease Z; Region: RNase_Z; TIGR02651
158879004570	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
158879004571	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
158879004572	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
158879004573	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
158879004574	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
158879004575	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
158879004576	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
158879004577	Ca binding site [ion binding]; other site
158879004578	active site
158879004579	catalytic site [active]
158879004580	Transcriptional regulators [Transcription]; Region: PurR; COG1609
158879004581	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
158879004582	DNA binding site [nucleotide binding]
158879004583	domain linker motif; other site
158879004584	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
158879004585	putative ligand binding site [chemical binding]; other site
158879004586	putative dimerization interface [polypeptide binding]; other site
158879004587	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
158879004588	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
158879004589	H+ Antiporter protein; Region: 2A0121; TIGR00900
158879004590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879004591	putative substrate translocation pore; other site
158879004592	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
158879004593	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
158879004594	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
158879004595	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
158879004596	peptidase T-like protein; Region: PepT-like; TIGR01883
158879004597	metal binding site [ion binding]; metal-binding site
158879004598	putative dimer interface [polypeptide binding]; other site
158879004599	Predicted membrane protein [Function unknown]; Region: COG4129
158879004600	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
158879004601	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
158879004602	Disulphide isomerase; Region: Disulph_isomer; pfam06491
158879004603	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
158879004604	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
158879004605	E3 interaction surface; other site
158879004606	lipoyl attachment site [posttranslational modification]; other site
158879004607	e3 binding domain; Region: E3_binding; pfam02817
158879004608	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
158879004609	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
158879004610	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
158879004611	alpha subunit interface [polypeptide binding]; other site
158879004612	TPP binding site [chemical binding]; other site
158879004613	heterodimer interface [polypeptide binding]; other site
158879004614	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
158879004615	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
158879004616	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
158879004617	tetramer interface [polypeptide binding]; other site
158879004618	TPP-binding site [chemical binding]; other site
158879004619	heterodimer interface [polypeptide binding]; other site
158879004620	phosphorylation loop region [posttranslational modification]
158879004621	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
158879004622	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
158879004623	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
158879004624	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
158879004625	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
158879004626	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
158879004627	Walker A/P-loop; other site
158879004628	ATP binding site [chemical binding]; other site
158879004629	Q-loop/lid; other site
158879004630	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
158879004631	ABC transporter signature motif; other site
158879004632	Walker B; other site
158879004633	D-loop; other site
158879004634	H-loop/switch region; other site
158879004635	arginine repressor; Provisional; Region: PRK04280
158879004636	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
158879004637	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
158879004638	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
158879004639	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
158879004640	substrate binding pocket [chemical binding]; other site
158879004641	chain length determination region; other site
158879004642	substrate-Mg2+ binding site; other site
158879004643	catalytic residues [active]
158879004644	aspartate-rich region 1; other site
158879004645	active site lid residues [active]
158879004646	aspartate-rich region 2; other site
158879004647	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068
158879004648	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
158879004649	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
158879004650	generic binding surface II; other site
158879004651	generic binding surface I; other site
158879004652	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
158879004653	putative RNA binding site [nucleotide binding]; other site
158879004654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
158879004655	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
158879004656	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
158879004657	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
158879004658	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
158879004659	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
158879004660	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
158879004661	carboxyltransferase (CT) interaction site; other site
158879004662	biotinylation site [posttranslational modification]; other site
158879004663	elongation factor P; Validated; Region: PRK00529
158879004664	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
158879004665	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
158879004666	RNA binding site [nucleotide binding]; other site
158879004667	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
158879004668	RNA binding site [nucleotide binding]; other site
158879004669	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
158879004670	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
158879004671	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
158879004672	active site
158879004673	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
158879004674	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
158879004675	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
158879004676	active site residue [active]
158879004677	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
158879004678	tetramer interface [polypeptide binding]; other site
158879004679	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879004680	catalytic residue [active]
158879004681	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
158879004682	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
158879004683	tetramer interface [polypeptide binding]; other site
158879004684	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879004685	catalytic residue [active]
158879004686	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
158879004687	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
158879004688	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
158879004689	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
158879004690	ADP binding site [chemical binding]; other site
158879004691	magnesium binding site [ion binding]; other site
158879004692	putative shikimate binding site; other site
158879004693	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
158879004694	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
158879004695	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
158879004696	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
158879004697	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
158879004698	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
158879004699	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
158879004700	Type II/IV secretion system protein; Region: T2SE; pfam00437
158879004701	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
158879004702	Walker A motif; other site
158879004703	ATP binding site [chemical binding]; other site
158879004704	Walker B motif; other site
158879004705	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
158879004706	Uncharacterized conserved protein [Function unknown]; Region: COG0011
158879004707	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
158879004708	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
158879004709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
158879004710	Rhomboid family; Region: Rhomboid; pfam01694
158879004711	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
158879004712	binding surface
158879004713	TPR motif; other site
158879004714	Tetratricopeptide repeat; Region: TPR_16; pfam13432
158879004715	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
158879004716	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
158879004717	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
158879004718	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
158879004719	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
158879004720	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
158879004721	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
158879004722	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
158879004723	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
158879004724	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
158879004725	metal binding site 2 [ion binding]; metal-binding site
158879004726	putative DNA binding helix; other site
158879004727	metal binding site 1 [ion binding]; metal-binding site
158879004728	dimer interface [polypeptide binding]; other site
158879004729	structural Zn2+ binding site [ion binding]; other site
158879004730	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
158879004731	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
158879004732	ABC-ATPase subunit  interface; other site
158879004733	dimer interface [polypeptide binding]; other site
158879004734	putative PBP binding regions; other site
158879004735	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
158879004736	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
158879004737	endonuclease IV; Provisional; Region: PRK01060
158879004738	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
158879004739	AP (apurinic/apyrimidinic) site pocket; other site
158879004740	DNA interaction; other site
158879004741	Metal-binding active site; metal-binding site
158879004742	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
158879004743	DEAD-like helicases superfamily; Region: DEXDc; smart00487
158879004744	ATP binding site [chemical binding]; other site
158879004745	putative Mg++ binding site [ion binding]; other site
158879004746	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
158879004747	nucleotide binding region [chemical binding]; other site
158879004748	ATP-binding site [chemical binding]; other site
158879004749	Uncharacterized conserved protein [Function unknown]; Region: COG0327
158879004750	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
158879004751	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
158879004752	Uncharacterized conserved protein [Function unknown]; Region: COG0327
158879004753	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
158879004754	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
158879004755	Family of unknown function (DUF633); Region: DUF633; pfam04816
158879004756	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
158879004757	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
158879004758	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
158879004759	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
158879004760	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
158879004761	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
158879004762	DNA binding residues [nucleotide binding]
158879004763	DNA primase, catalytic core; Region: dnaG; TIGR01391
158879004764	CHC2 zinc finger; Region: zf-CHC2; pfam01807
158879004765	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
158879004766	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
158879004767	active site
158879004768	metal binding site [ion binding]; metal-binding site
158879004769	interdomain interaction site; other site
158879004770	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
158879004771	HTH domain; Region: HTH_11; pfam08279
158879004772	FOG: CBS domain [General function prediction only]; Region: COG0517
158879004773	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
158879004774	glycyl-tRNA synthetase; Provisional; Region: PRK04173
158879004775	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
158879004776	motif 1; other site
158879004777	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
158879004778	active site
158879004779	motif 2; other site
158879004780	motif 3; other site
158879004781	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
158879004782	anticodon binding site; other site
158879004783	DNA repair protein RecO; Region: reco; TIGR00613
158879004784	Recombination protein O N terminal; Region: RecO_N; pfam11967
158879004785	Recombination protein O C terminal; Region: RecO_C; pfam02565
158879004786	GTPase Era; Reviewed; Region: era; PRK00089
158879004787	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
158879004788	G1 box; other site
158879004789	GTP/Mg2+ binding site [chemical binding]; other site
158879004790	Switch I region; other site
158879004791	G2 box; other site
158879004792	Switch II region; other site
158879004793	G3 box; other site
158879004794	G4 box; other site
158879004795	G5 box; other site
158879004796	KH domain; Region: KH_2; pfam07650
158879004797	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
158879004798	active site
158879004799	catalytic motif [active]
158879004800	Zn binding site [ion binding]; other site
158879004801	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
158879004802	metal-binding heat shock protein; Provisional; Region: PRK00016
158879004803	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
158879004804	PhoH-like protein; Region: PhoH; pfam02562
158879004805	hypothetical protein; Provisional; Region: PRK13665
158879004806	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
158879004807	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
158879004808	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
158879004809	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
158879004810	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
158879004811	FeS/SAM binding site; other site
158879004812	TRAM domain; Region: TRAM; cl01282
158879004813	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
158879004814	RNA methyltransferase, RsmE family; Region: TIGR00046
158879004815	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
158879004816	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879004817	S-adenosylmethionine binding site [chemical binding]; other site
158879004818	chaperone protein DnaJ; Provisional; Region: PRK14280
158879004819	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
158879004820	HSP70 interaction site [polypeptide binding]; other site
158879004821	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
158879004822	substrate binding site [polypeptide binding]; other site
158879004823	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
158879004824	Zn binding sites [ion binding]; other site
158879004825	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
158879004826	dimer interface [polypeptide binding]; other site
158879004827	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
158879004828	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
158879004829	nucleotide binding site [chemical binding]; other site
158879004830	NEF interaction site [polypeptide binding]; other site
158879004831	SBD interface [polypeptide binding]; other site
158879004832	heat shock protein GrpE; Provisional; Region: PRK14140
158879004833	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
158879004834	dimer interface [polypeptide binding]; other site
158879004835	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
158879004836	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
158879004837	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
158879004838	Tubulin C-terminal domain; Region: Tubulin_C; cl10021
158879004839	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
158879004840	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
158879004841	FeS/SAM binding site; other site
158879004842	HemN C-terminal domain; Region: HemN_C; pfam06969
158879004843	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
158879004844	GTP-binding protein LepA; Provisional; Region: PRK05433
158879004845	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
158879004846	G1 box; other site
158879004847	putative GEF interaction site [polypeptide binding]; other site
158879004848	GTP/Mg2+ binding site [chemical binding]; other site
158879004849	Switch I region; other site
158879004850	G2 box; other site
158879004851	G3 box; other site
158879004852	Switch II region; other site
158879004853	G4 box; other site
158879004854	G5 box; other site
158879004855	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
158879004856	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
158879004857	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
158879004858	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
158879004859	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
158879004860	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
158879004861	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
158879004862	Competence protein; Region: Competence; pfam03772
158879004863	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
158879004864	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
158879004865	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
158879004866	catalytic motif [active]
158879004867	Zn binding site [ion binding]; other site
158879004868	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
158879004869	Helix-hairpin-helix motif; Region: HHH; pfam00633
158879004870	Methyltransferase domain; Region: Methyltransf_31; pfam13847
158879004871	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879004872	S-adenosylmethionine binding site [chemical binding]; other site
158879004873	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
158879004874	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
158879004875	Zn2+ binding site [ion binding]; other site
158879004876	Mg2+ binding site [ion binding]; other site
158879004877	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
158879004878	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
158879004879	active site
158879004880	(T/H)XGH motif; other site
158879004881	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
158879004882	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
158879004883	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
158879004884	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
158879004885	shikimate binding site; other site
158879004886	NAD(P) binding site [chemical binding]; other site
158879004887	GTPase YqeH; Provisional; Region: PRK13796
158879004888	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
158879004889	GTP/Mg2+ binding site [chemical binding]; other site
158879004890	G4 box; other site
158879004891	G5 box; other site
158879004892	G1 box; other site
158879004893	Switch I region; other site
158879004894	G2 box; other site
158879004895	G3 box; other site
158879004896	Switch II region; other site
158879004897	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
158879004898	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879004899	active site
158879004900	motif I; other site
158879004901	motif II; other site
158879004902	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
158879004903	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
158879004904	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879004905	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
158879004906	Fic family protein [Function unknown]; Region: COG3177
158879004907	Fic/DOC family; Region: Fic; pfam02661
158879004908	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
158879004909	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
158879004910	putative active site [active]
158879004911	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
158879004912	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
158879004913	ATP-grasp domain; Region: ATP-grasp_4; cl17255
158879004914	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
158879004915	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
158879004916	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
158879004917	carboxyltransferase (CT) interaction site; other site
158879004918	biotinylation site [posttranslational modification]; other site
158879004919	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
158879004920	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
158879004921	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
158879004922	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
158879004923	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
158879004924	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
158879004925	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
158879004926	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
158879004927	Sugar specificity; other site
158879004928	Pyrimidine base specificity; other site
158879004929	ATP-binding site [chemical binding]; other site
158879004930	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
158879004931	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
158879004932	Peptidase family U32; Region: Peptidase_U32; pfam01136
158879004933	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
158879004934	Peptidase family U32; Region: Peptidase_U32; pfam01136
158879004935	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
158879004936	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879004937	S-adenosylmethionine binding site [chemical binding]; other site
158879004938	hypothetical protein; Provisional; Region: PRK13678
158879004939	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
158879004940	hypothetical protein; Provisional; Region: PRK05473
158879004941	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
158879004942	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
158879004943	motif 1; other site
158879004944	active site
158879004945	motif 2; other site
158879004946	motif 3; other site
158879004947	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
158879004948	DHHA1 domain; Region: DHHA1; pfam02272
158879004949	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
158879004950	AAA domain; Region: AAA_30; pfam13604
158879004951	Family description; Region: UvrD_C_2; pfam13538
158879004952	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
158879004953	binding surface
158879004954	TPR motif; other site
158879004955	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
158879004956	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
158879004957	binding surface
158879004958	TPR motif; other site
158879004959	TPR repeat; Region: TPR_11; pfam13414
158879004960	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
158879004961	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
158879004962	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
158879004963	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
158879004964	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
158879004965	catalytic residue [active]
158879004966	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
158879004967	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
158879004968	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
158879004969	Predicted transcriptional regulator [Transcription]; Region: COG1959
158879004970	Transcriptional regulator; Region: Rrf2; pfam02082
158879004971	recombination factor protein RarA; Reviewed; Region: PRK13342
158879004972	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879004973	Walker A motif; other site
158879004974	ATP binding site [chemical binding]; other site
158879004975	Walker B motif; other site
158879004976	arginine finger; other site
158879004977	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
158879004978	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
158879004979	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
158879004980	putative ATP binding site [chemical binding]; other site
158879004981	putative substrate interface [chemical binding]; other site
158879004982	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
158879004983	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
158879004984	dimer interface [polypeptide binding]; other site
158879004985	anticodon binding site; other site
158879004986	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
158879004987	homodimer interface [polypeptide binding]; other site
158879004988	motif 1; other site
158879004989	active site
158879004990	motif 2; other site
158879004991	GAD domain; Region: GAD; pfam02938
158879004992	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
158879004993	motif 3; other site
158879004994	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
158879004995	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
158879004996	dimer interface [polypeptide binding]; other site
158879004997	motif 1; other site
158879004998	active site
158879004999	motif 2; other site
158879005000	motif 3; other site
158879005001	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
158879005002	anticodon binding site; other site
158879005003	Bacterial SH3 domain homologues; Region: SH3b; smart00287
158879005004	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
158879005005	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
158879005006	active site
158879005007	metal binding site [ion binding]; metal-binding site
158879005008	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
158879005009	putative active site [active]
158879005010	dimerization interface [polypeptide binding]; other site
158879005011	putative tRNAtyr binding site [nucleotide binding]; other site
158879005012	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
158879005013	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
158879005014	Zn2+ binding site [ion binding]; other site
158879005015	Mg2+ binding site [ion binding]; other site
158879005016	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
158879005017	synthetase active site [active]
158879005018	NTP binding site [chemical binding]; other site
158879005019	metal binding site [ion binding]; metal-binding site
158879005020	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
158879005021	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
158879005022	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
158879005023	active site
158879005024	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
158879005025	DHH family; Region: DHH; pfam01368
158879005026	DHHA1 domain; Region: DHHA1; pfam02272
158879005027	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
158879005028	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
158879005029	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
158879005030	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
158879005031	Protein export membrane protein; Region: SecD_SecF; pfam02355
158879005032	Preprotein translocase subunit; Region: YajC; pfam02699
158879005033	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
158879005034	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
158879005035	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
158879005036	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
158879005037	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
158879005038	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879005039	Walker A motif; other site
158879005040	ATP binding site [chemical binding]; other site
158879005041	Walker B motif; other site
158879005042	arginine finger; other site
158879005043	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
158879005044	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
158879005045	RuvA N terminal domain; Region: RuvA_N; pfam01330
158879005046	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
158879005047	ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492
158879005048	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
158879005049	GTPase CgtA; Reviewed; Region: obgE; PRK12297
158879005050	GTP1/OBG; Region: GTP1_OBG; pfam01018
158879005051	Obg GTPase; Region: Obg; cd01898
158879005052	G1 box; other site
158879005053	GTP/Mg2+ binding site [chemical binding]; other site
158879005054	Switch I region; other site
158879005055	G2 box; other site
158879005056	G3 box; other site
158879005057	Switch II region; other site
158879005058	G4 box; other site
158879005059	G5 box; other site
158879005060	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
158879005061	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
158879005062	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
158879005063	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
158879005064	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
158879005065	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
158879005066	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
158879005067	rod shape-determining protein MreC; Region: MreC; pfam04085
158879005068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879005069	S-adenosylmethionine binding site [chemical binding]; other site
158879005070	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
158879005071	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879005072	S-adenosylmethionine binding site [chemical binding]; other site
158879005073	aminoglycoside resistance protein; Provisional; Region: PRK13746
158879005074	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
158879005075	active site
158879005076	NTP binding site [chemical binding]; other site
158879005077	metal binding triad [ion binding]; metal-binding site
158879005078	antibiotic binding site [chemical binding]; other site
158879005079	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
158879005080	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
158879005081	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
158879005082	Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195
158879005083	Int/Topo IB signature motif; other site
158879005084	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
158879005085	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
158879005086	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
158879005087	Int/Topo IB signature motif; other site
158879005088	hypothetical protein; Reviewed; Region: PRK00024
158879005089	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
158879005090	MPN+ (JAMM) motif; other site
158879005091	Zinc-binding site [ion binding]; other site
158879005092	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
158879005093	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
158879005094	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
158879005095	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
158879005096	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
158879005097	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
158879005098	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
158879005099	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
158879005100	active site
158879005101	HIGH motif; other site
158879005102	nucleotide binding site [chemical binding]; other site
158879005103	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
158879005104	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
158879005105	active site
158879005106	KMSKS motif; other site
158879005107	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
158879005108	tRNA binding surface [nucleotide binding]; other site
158879005109	anticodon binding site; other site
158879005110	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
158879005111	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
158879005112	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
158879005113	Putative ammonia monooxygenase; Region: AmoA; pfam05145
158879005114	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
158879005115	similar to hypothetical protein
158879005116	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
158879005117	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
158879005118	inhibitor-cofactor binding pocket; inhibition site
158879005119	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879005120	catalytic residue [active]
158879005121	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
158879005122	dimer interface [polypeptide binding]; other site
158879005123	active site
158879005124	Schiff base residues; other site
158879005125	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
158879005126	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
158879005127	active site
158879005128	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
158879005129	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
158879005130	domain interfaces; other site
158879005131	active site
158879005132	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755
158879005133	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
158879005134	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
158879005135	tRNA; other site
158879005136	putative tRNA binding site [nucleotide binding]; other site
158879005137	putative NADP binding site [chemical binding]; other site
158879005138	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
158879005139	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
158879005140	G1 box; other site
158879005141	GTP/Mg2+ binding site [chemical binding]; other site
158879005142	Switch I region; other site
158879005143	G2 box; other site
158879005144	G3 box; other site
158879005145	Switch II region; other site
158879005146	G4 box; other site
158879005147	G5 box; other site
158879005148	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
158879005149	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
158879005150	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879005151	Walker A motif; other site
158879005152	ATP binding site [chemical binding]; other site
158879005153	Walker B motif; other site
158879005154	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
158879005155	trigger factor; Provisional; Region: tig; PRK01490
158879005156	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
158879005157	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
158879005158	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
158879005159	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
158879005160	23S rRNA binding site [nucleotide binding]; other site
158879005161	L21 binding site [polypeptide binding]; other site
158879005162	L13 binding site [polypeptide binding]; other site
158879005163	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
158879005164	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
158879005165	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
158879005166	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
158879005167	lysine transporter; Provisional; Region: PRK10836
158879005168	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
158879005169	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
158879005170	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
158879005171	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
158879005172	active site
158879005173	dimer interface [polypeptide binding]; other site
158879005174	motif 1; other site
158879005175	motif 2; other site
158879005176	motif 3; other site
158879005177	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
158879005178	anticodon binding site; other site
158879005179	primosomal protein DnaI; Reviewed; Region: PRK08939
158879005180	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
158879005181	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879005182	Walker A motif; other site
158879005183	ATP binding site [chemical binding]; other site
158879005184	Walker B motif; other site
158879005185	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
158879005186	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
158879005187	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
158879005188	ATP cone domain; Region: ATP-cone; pfam03477
158879005189	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
158879005190	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
158879005191	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
158879005192	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
158879005193	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
158879005194	CoA-binding site [chemical binding]; other site
158879005195	ATP-binding [chemical binding]; other site
158879005196	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
158879005197	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
158879005198	DNA binding site [nucleotide binding]
158879005199	catalytic residue [active]
158879005200	H2TH interface [polypeptide binding]; other site
158879005201	putative catalytic residues [active]
158879005202	turnover-facilitating residue; other site
158879005203	intercalation triad [nucleotide binding]; other site
158879005204	8OG recognition residue [nucleotide binding]; other site
158879005205	putative reading head residues; other site
158879005206	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
158879005207	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
158879005208	DNA polymerase I; Provisional; Region: PRK05755
158879005209	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
158879005210	active site
158879005211	metal binding site 1 [ion binding]; metal-binding site
158879005212	putative 5' ssDNA interaction site; other site
158879005213	metal binding site 3; metal-binding site
158879005214	metal binding site 2 [ion binding]; metal-binding site
158879005215	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
158879005216	putative DNA binding site [nucleotide binding]; other site
158879005217	putative metal binding site [ion binding]; other site
158879005218	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
158879005219	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
158879005220	active site
158879005221	DNA binding site [nucleotide binding]
158879005222	catalytic site [active]
158879005223	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
158879005224	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
158879005225	dimer interface [polypeptide binding]; other site
158879005226	phosphorylation site [posttranslational modification]
158879005227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879005228	ATP binding site [chemical binding]; other site
158879005229	Mg2+ binding site [ion binding]; other site
158879005230	G-X-G motif; other site
158879005231	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
158879005232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879005233	active site
158879005234	phosphorylation site [posttranslational modification]
158879005235	intermolecular recognition site; other site
158879005236	dimerization interface [polypeptide binding]; other site
158879005237	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
158879005238	DNA binding site [nucleotide binding]
158879005239	isocitrate dehydrogenase; Reviewed; Region: PRK07006
158879005240	isocitrate dehydrogenase; Validated; Region: PRK07362
158879005241	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
158879005242	dimer interface [polypeptide binding]; other site
158879005243	Citrate synthase; Region: Citrate_synt; pfam00285
158879005244	active site
158879005245	citrylCoA binding site [chemical binding]; other site
158879005246	oxalacetate/citrate binding site [chemical binding]; other site
158879005247	coenzyme A binding site [chemical binding]; other site
158879005248	catalytic triad [active]
158879005249	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
158879005250	pyruvate kinase; Provisional; Region: PRK06354
158879005251	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
158879005252	domain interfaces; other site
158879005253	active site
158879005254	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
158879005255	6-phosphofructokinase; Provisional; Region: PRK03202
158879005256	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
158879005257	dimerization interface [polypeptide binding]; other site
158879005258	allosteric effector site; other site
158879005259	active site
158879005260	ADP/pyrophosphate binding site [chemical binding]; other site
158879005261	fructose-1,6-bisphosphate binding site; other site
158879005262	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
158879005263	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
158879005264	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
158879005265	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
158879005266	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
158879005267	Malic enzyme, N-terminal domain; Region: malic; pfam00390
158879005268	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
158879005269	putative NAD(P) binding site [chemical binding]; other site
158879005270	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
158879005271	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
158879005272	active site
158879005273	PHP Thumb interface [polypeptide binding]; other site
158879005274	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
158879005275	generic binding surface I; other site
158879005276	generic binding surface II; other site
158879005277	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
158879005278	DHH family; Region: DHH; pfam01368
158879005279	DHHA1 domain; Region: DHHA1; pfam02272
158879005280	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
158879005281	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
158879005282	DNA-binding site [nucleotide binding]; DNA binding site
158879005283	DRTGG domain; Region: DRTGG; pfam07085
158879005284	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
158879005285	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
158879005286	active site 2 [active]
158879005287	active site 1 [active]
158879005288	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
158879005289	Ligand Binding Site [chemical binding]; other site
158879005290	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
158879005291	metal-dependent hydrolase; Provisional; Region: PRK00685
158879005292	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
158879005293	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
158879005294	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
158879005295	active site
158879005296	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
158879005297	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
158879005298	hexamer interface [polypeptide binding]; other site
158879005299	ligand binding site [chemical binding]; other site
158879005300	putative active site [active]
158879005301	NAD(P) binding site [chemical binding]; other site
158879005302	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
158879005303	Ligand Binding Site [chemical binding]; other site
158879005304	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
158879005305	propionate/acetate kinase; Provisional; Region: PRK12379
158879005306	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
158879005307	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879005308	S-adenosylmethionine binding site [chemical binding]; other site
158879005309	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
158879005310	dimer interface [polypeptide binding]; other site
158879005311	catalytic triad [active]
158879005312	peroxidatic and resolving cysteines [active]
158879005313	hypothetical protein; Provisional; Region: PRK10621
158879005314	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
158879005315	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
158879005316	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
158879005317	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
158879005318	Ligand Binding Site [chemical binding]; other site
158879005319	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
158879005320	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
158879005321	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
158879005322	catalytic residue [active]
158879005323	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
158879005324	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
158879005325	GAF domain; Region: GAF_2; pfam13185
158879005326	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
158879005327	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
158879005328	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
158879005329	RNA binding surface [nucleotide binding]; other site
158879005330	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
158879005331	Transposase; Region: DDE_Tnp_ISL3; pfam01610
158879005332	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
158879005333	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
158879005334	active site
158879005335	catalytic site [active]
158879005336	OsmC-like protein; Region: OsmC; cl00767
158879005337	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
158879005338	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
158879005339	catalytic residue [active]
158879005340	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
158879005341	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
158879005342	ligand binding site [chemical binding]; other site
158879005343	NAD binding site [chemical binding]; other site
158879005344	dimerization interface [polypeptide binding]; other site
158879005345	catalytic site [active]
158879005346	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
158879005347	putative L-serine binding site [chemical binding]; other site
158879005348	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
158879005349	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879005350	motif II; other site
158879005351	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
158879005352	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
158879005353	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
158879005354	active site turn [active]
158879005355	phosphorylation site [posttranslational modification]
158879005356	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
158879005357	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
158879005358	putative acyl-acceptor binding pocket; other site
158879005359	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
158879005360	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
158879005361	protein binding site [polypeptide binding]; other site
158879005362	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
158879005363	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
158879005364	active site
158879005365	HIGH motif; other site
158879005366	dimer interface [polypeptide binding]; other site
158879005367	KMSKS motif; other site
158879005368	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
158879005369	RNA binding surface [nucleotide binding]; other site
158879005370	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
158879005371	Transglycosylase; Region: Transgly; pfam00912
158879005372	haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658
158879005373	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
158879005374	NEAr Transporter domain; Region: NEAT; smart00725
158879005375	NEAr Transporter domain; Region: NEAT; smart00725
158879005376	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
158879005377	heme-binding site [chemical binding]; other site
158879005378	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
158879005379	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
158879005380	Potassium binding sites [ion binding]; other site
158879005381	Cesium cation binding sites [ion binding]; other site
158879005382	acetyl-CoA synthetase; Provisional; Region: PRK04319
158879005383	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
158879005384	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
158879005385	active site
158879005386	acyl-activating enzyme (AAE) consensus motif; other site
158879005387	putative CoA binding site [chemical binding]; other site
158879005388	AMP binding site [chemical binding]; other site
158879005389	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
158879005390	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
158879005391	active site
158879005392	Zn binding site [ion binding]; other site
158879005393	catabolite control protein A; Region: ccpA; TIGR01481
158879005394	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
158879005395	DNA binding site [nucleotide binding]
158879005396	domain linker motif; other site
158879005397	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
158879005398	dimerization interface [polypeptide binding]; other site
158879005399	effector binding site; other site
158879005400	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
158879005401	Chorismate mutase type II; Region: CM_2; cl00693
158879005402	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
158879005403	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
158879005404	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
158879005405	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
158879005406	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
158879005407	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
158879005408	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
158879005409	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
158879005410	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
158879005411	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
158879005412	putative tRNA-binding site [nucleotide binding]; other site
158879005413	hypothetical protein; Provisional; Region: PRK13668
158879005414	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
158879005415	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
158879005416	catalytic residues [active]
158879005417	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
158879005418	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
158879005419	oligomer interface [polypeptide binding]; other site
158879005420	active site
158879005421	metal binding site [ion binding]; metal-binding site
158879005422	Predicted small secreted protein [Function unknown]; Region: COG5584
158879005423	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
158879005424	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879005425	S-adenosylmethionine binding site [chemical binding]; other site
158879005426	Phosphotransferase enzyme family; Region: APH; pfam01636
158879005427	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
158879005428	active site
158879005429	substrate binding site [chemical binding]; other site
158879005430	ATP binding site [chemical binding]; other site
158879005431	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
158879005432	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
158879005433	homodimer interface [polypeptide binding]; other site
158879005434	substrate-cofactor binding pocket; other site
158879005435	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879005436	catalytic residue [active]
158879005437	dipeptidase PepV; Reviewed; Region: PRK07318
158879005438	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
158879005439	active site
158879005440	metal binding site [ion binding]; metal-binding site
158879005441	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
158879005442	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
158879005443	RNA binding surface [nucleotide binding]; other site
158879005444	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
158879005445	active site
158879005446	uracil binding [chemical binding]; other site
158879005447	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
158879005448	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
158879005449	HI0933-like protein; Region: HI0933_like; pfam03486
158879005450	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
158879005451	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
158879005452	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005453	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005454	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005455	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005456	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005457	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005458	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005459	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005460	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005461	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005462	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005463	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005464	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005465	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005466	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879005467	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
158879005468	active site residue [active]
158879005469	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
158879005470	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
158879005471	HIGH motif; other site
158879005472	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
158879005473	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
158879005474	active site
158879005475	KMSKS motif; other site
158879005476	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
158879005477	tRNA binding surface [nucleotide binding]; other site
158879005478	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879005479	Major Facilitator Superfamily; Region: MFS_1; pfam07690
158879005480	putative substrate translocation pore; other site
158879005481	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
158879005482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879005483	S-adenosylmethionine binding site [chemical binding]; other site
158879005484	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
158879005485	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
158879005486	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
158879005487	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
158879005488	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
158879005489	homopentamer interface [polypeptide binding]; other site
158879005490	active site
158879005491	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
158879005492	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
158879005493	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
158879005494	dimerization interface [polypeptide binding]; other site
158879005495	active site
158879005496	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
158879005497	Lumazine binding domain; Region: Lum_binding; pfam00677
158879005498	Lumazine binding domain; Region: Lum_binding; pfam00677
158879005499	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
158879005500	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
158879005501	catalytic motif [active]
158879005502	Zn binding site [ion binding]; other site
158879005503	RibD C-terminal domain; Region: RibD_C; cl17279
158879005504	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
158879005505	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
158879005506	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
158879005507	dimerization interface [polypeptide binding]; other site
158879005508	putative DNA binding site [nucleotide binding]; other site
158879005509	putative Zn2+ binding site [ion binding]; other site
158879005510	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
158879005511	arsenical pump membrane protein; Provisional; Region: PRK15445
158879005512	transmembrane helices; other site
158879005513	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
158879005514	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
158879005515	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
158879005516	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
158879005517	DNA binding residues [nucleotide binding]
158879005518	CAAX protease self-immunity; Region: Abi; pfam02517
158879005519	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
158879005520	active site
158879005521	intersubunit interactions; other site
158879005522	catalytic residue [active]
158879005523	camphor resistance protein CrcB; Provisional; Region: PRK14201
158879005524	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
158879005525	framshifted transposase
158879005526	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
158879005527	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
158879005528	active site
158879005529	catalytic tetrad [active]
158879005530	S-adenosylmethionine synthetase; Validated; Region: PRK05250
158879005531	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
158879005532	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
158879005533	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
158879005534	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
158879005535	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
158879005536	active site
158879005537	substrate-binding site [chemical binding]; other site
158879005538	metal-binding site [ion binding]
158879005539	ATP binding site [chemical binding]; other site
158879005540	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
158879005541	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
158879005542	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
158879005543	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
158879005544	nudix motif; other site
158879005545	Haemolytic domain; Region: Haemolytic; pfam01809
158879005546	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
158879005547	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
158879005548	metal binding site [ion binding]; metal-binding site
158879005549	substrate binding pocket [chemical binding]; other site
158879005550	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
158879005551	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
158879005552	acyl-activating enzyme (AAE) consensus motif; other site
158879005553	putative AMP binding site [chemical binding]; other site
158879005554	putative active site [active]
158879005555	putative CoA binding site [chemical binding]; other site
158879005556	Excalibur calcium-binding domain; Region: Excalibur; smart00894
158879005557	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
158879005558	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
158879005559	Pathogenicity island SaPIn3
158879005560	frameshifted transposase
158879005561	Winged helix-turn helix; Region: HTH_29; pfam13551
158879005562	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
158879005563	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
158879005564	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
158879005565	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
158879005566	HsdM N-terminal domain; Region: HsdM_N; pfam12161
158879005567	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879005568	S-adenosylmethionine binding site [chemical binding]; other site
158879005569	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
158879005570	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
158879005571	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
158879005572	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
158879005573	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
158879005574	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
158879005575	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
158879005576	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
158879005577	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
158879005578	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
158879005579	beta-channel forming cytolysin; Region: hlyII; TIGR01002
158879005580	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
158879005581	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
158879005582	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
158879005583	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
158879005584	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
158879005585	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
158879005586	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879005587	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
158879005588	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879005589	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879005590	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
158879005591	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
158879005592	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879005593	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
158879005594	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879005595	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
158879005596	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879005597	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
158879005598	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
158879005599	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
158879005600	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
158879005601	ferrochelatase; Provisional; Region: PRK12435
158879005602	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
158879005603	C-terminal domain interface [polypeptide binding]; other site
158879005604	active site
158879005605	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
158879005606	active site
158879005607	N-terminal domain interface [polypeptide binding]; other site
158879005608	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
158879005609	substrate binding site [chemical binding]; other site
158879005610	active site
158879005611	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
158879005612	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
158879005613	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
158879005614	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
158879005615	Walker A/P-loop; other site
158879005616	ATP binding site [chemical binding]; other site
158879005617	Q-loop/lid; other site
158879005618	ABC transporter signature motif; other site
158879005619	Walker B; other site
158879005620	D-loop; other site
158879005621	H-loop/switch region; other site
158879005622	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
158879005623	HIT family signature motif; other site
158879005624	catalytic residue [active]
158879005625	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
158879005626	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
158879005627	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095
158879005628	SurA N-terminal domain; Region: SurA_N_3; cl07813
158879005629	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
158879005630	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
158879005631	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
158879005632	generic binding surface II; other site
158879005633	generic binding surface I; other site
158879005634	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
158879005635	Zn2+ binding site [ion binding]; other site
158879005636	Mg2+ binding site [ion binding]; other site
158879005637	Uncharacterized conserved protein [Function unknown]; Region: COG4717
158879005638	P-loop containing region of AAA domain; Region: AAA_29; cl17516
158879005639	Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273
158879005640	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
158879005641	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
158879005642	active site
158879005643	metal binding site [ion binding]; metal-binding site
158879005644	DNA binding site [nucleotide binding]
158879005645	hypothetical protein; Provisional; Region: PRK13676
158879005646	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
158879005647	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
158879005648	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
158879005649	non-specific DNA binding site [nucleotide binding]; other site
158879005650	salt bridge; other site
158879005651	sequence-specific DNA binding site [nucleotide binding]; other site
158879005652	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
158879005653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879005654	active site
158879005655	phosphorylation site [posttranslational modification]
158879005656	intermolecular recognition site; other site
158879005657	dimerization interface [polypeptide binding]; other site
158879005658	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
158879005659	DNA binding residues [nucleotide binding]
158879005660	dimerization interface [polypeptide binding]; other site
158879005661	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
158879005662	GAF domain; Region: GAF_3; pfam13492
158879005663	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
158879005664	Histidine kinase; Region: HisKA_3; pfam07730
158879005665	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879005666	ATP binding site [chemical binding]; other site
158879005667	Mg2+ binding site [ion binding]; other site
158879005668	G-X-G motif; other site
158879005669	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
158879005670	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
158879005671	active site
158879005672	fumarate hydratase; Reviewed; Region: fumC; PRK00485
158879005673	Class II fumarases; Region: Fumarase_classII; cd01362
158879005674	active site
158879005675	tetramer interface [polypeptide binding]; other site
158879005676	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
158879005677	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
158879005678	active site
158879005679	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
158879005680	epoxyqueuosine reductase; Region: TIGR00276
158879005681	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
158879005682	HEAT repeats; Region: HEAT_2; pfam13646
158879005683	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
158879005684	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
158879005685	Walker A/P-loop; other site
158879005686	ATP binding site [chemical binding]; other site
158879005687	Q-loop/lid; other site
158879005688	ABC transporter signature motif; other site
158879005689	Walker B; other site
158879005690	D-loop; other site
158879005691	H-loop/switch region; other site
158879005692	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
158879005693	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
158879005694	substrate binding pocket [chemical binding]; other site
158879005695	membrane-bound complex binding site; other site
158879005696	hinge residues; other site
158879005697	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
158879005698	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879005699	dimer interface [polypeptide binding]; other site
158879005700	conserved gate region; other site
158879005701	putative PBP binding loops; other site
158879005702	ABC-ATPase subunit interface; other site
158879005703	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
158879005704	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
158879005705	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
158879005706	Transposase; Region: DDE_Tnp_ISL3; pfam01610
158879005707	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
158879005708	metal binding site 2 [ion binding]; metal-binding site
158879005709	putative DNA binding helix; other site
158879005710	metal binding site 1 [ion binding]; metal-binding site
158879005711	dimer interface [polypeptide binding]; other site
158879005712	structural Zn2+ binding site [ion binding]; other site
158879005713	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
158879005714	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
158879005715	putative ligand binding site [chemical binding]; other site
158879005716	NAD binding site [chemical binding]; other site
158879005717	catalytic site [active]
158879005718	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
158879005719	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
158879005720	catalytic triad [active]
158879005721	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
158879005722	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
158879005723	inhibitor-cofactor binding pocket; inhibition site
158879005724	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879005725	catalytic residue [active]
158879005726	Predicted membrane protein [Function unknown]; Region: COG4129
158879005727	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
158879005728	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
158879005729	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
158879005730	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
158879005731	Walker A/P-loop; other site
158879005732	ATP binding site [chemical binding]; other site
158879005733	Q-loop/lid; other site
158879005734	ABC transporter signature motif; other site
158879005735	Walker B; other site
158879005736	D-loop; other site
158879005737	H-loop/switch region; other site
158879005738	hypothetical protein; Provisional; Region: PRK13662
158879005739	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
158879005740	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
158879005741	minor groove reading motif; other site
158879005742	helix-hairpin-helix signature motif; other site
158879005743	substrate binding pocket [chemical binding]; other site
158879005744	active site
158879005745	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
158879005746	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
158879005747	DNA binding and oxoG recognition site [nucleotide binding]
158879005748	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
158879005749	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
158879005750	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
158879005751	Walker A/P-loop; other site
158879005752	ATP binding site [chemical binding]; other site
158879005753	Q-loop/lid; other site
158879005754	ABC transporter signature motif; other site
158879005755	Walker B; other site
158879005756	H-loop/switch region; other site
158879005757	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
158879005758	recombination regulator RecX; Provisional; Region: recX; PRK14135
158879005759	glycosyltransferase; Provisional; Region: PRK13481
158879005760	Transglycosylase; Region: Transgly; pfam00912
158879005761	intracellular protease, PfpI family; Region: PfpI; TIGR01382
158879005762	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
158879005763	proposed catalytic triad [active]
158879005764	conserved cys residue [active]
158879005765	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
158879005766	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
158879005767	FeS/SAM binding site; other site
158879005768	YfkB-like domain; Region: YfkB; pfam08756
158879005769	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
158879005770	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
158879005771	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
158879005772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840
158879005773	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
158879005774	Low molecular weight phosphatase family; Region: LMWPc; cd00115
158879005775	active site
158879005776	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
158879005777	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
158879005778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879005779	active site
158879005780	phosphorylation site [posttranslational modification]
158879005781	intermolecular recognition site; other site
158879005782	dimerization interface [polypeptide binding]; other site
158879005783	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
158879005784	DNA binding residues [nucleotide binding]
158879005785	dimerization interface [polypeptide binding]; other site
158879005786	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
158879005787	Histidine kinase; Region: HisKA_3; pfam07730
158879005788	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879005789	ATP binding site [chemical binding]; other site
158879005790	Mg2+ binding site [ion binding]; other site
158879005791	G-X-G motif; other site
158879005792	Predicted membrane protein [Function unknown]; Region: COG4758
158879005793	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
158879005794	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
158879005795	active site
158879005796	Predicted membrane protein [Function unknown]; Region: COG4129
158879005797	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
158879005798	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
158879005799	catalytic triad [active]
158879005800	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
158879005801	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
158879005802	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
158879005803	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
158879005804	Ferritin-like domain; Region: Ferritin; pfam00210
158879005805	ferroxidase diiron center [ion binding]; other site
158879005806	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
158879005807	active site
158879005808	catalytic site [active]
158879005809	substrate binding site [chemical binding]; other site
158879005810	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
158879005811	active site
158879005812	DNA polymerase IV; Validated; Region: PRK02406
158879005813	DNA binding site [nucleotide binding]
158879005814	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
158879005815	TRAM domain; Region: TRAM; cl01282
158879005816	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
158879005817	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879005818	S-adenosylmethionine binding site [chemical binding]; other site
158879005819	putative lipid kinase; Reviewed; Region: PRK13337
158879005820	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
158879005821	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
158879005822	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
158879005823	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
158879005824	GatB domain; Region: GatB_Yqey; pfam02637
158879005825	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
158879005826	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
158879005827	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
158879005828	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
158879005829	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
158879005830	Na binding site [ion binding]; other site
158879005831	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
158879005832	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
158879005833	putative dimer interface [polypeptide binding]; other site
158879005834	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
158879005835	putative dimer interface [polypeptide binding]; other site
158879005836	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
158879005837	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
158879005838	nucleotide binding pocket [chemical binding]; other site
158879005839	K-X-D-G motif; other site
158879005840	catalytic site [active]
158879005841	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
158879005842	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
158879005843	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
158879005844	Dimer interface [polypeptide binding]; other site
158879005845	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
158879005846	Part of AAA domain; Region: AAA_19; pfam13245
158879005847	Family description; Region: UvrD_C_2; pfam13538
158879005848	PcrB family; Region: PcrB; pfam01884
158879005849	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
158879005850	substrate binding site [chemical binding]; other site
158879005851	putative active site [active]
158879005852	dimer interface [polypeptide binding]; other site
158879005853	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
158879005854	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
158879005855	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
158879005856	tetramer interface [polypeptide binding]; other site
158879005857	active site
158879005858	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
158879005859	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
158879005860	Staphostatin A; Region: Staphostatin_A; pfam09022
158879005861	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
158879005862	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
158879005863	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
158879005864	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
158879005865	homodimer interface [polypeptide binding]; other site
158879005866	NAD binding pocket [chemical binding]; other site
158879005867	ATP binding pocket [chemical binding]; other site
158879005868	Mg binding site [ion binding]; other site
158879005869	active-site loop [active]
158879005870	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
158879005871	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
158879005872	active site
158879005873	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
158879005874	active site
158879005875	dimer interface [polypeptide binding]; other site
158879005876	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
158879005877	Prephenate dehydratase; Region: PDT; pfam00800
158879005878	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
158879005879	putative L-Phe binding site [chemical binding]; other site
158879005880	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
158879005881	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
158879005882	transmembrane helices; other site
158879005883	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
158879005884	Isochorismatase family; Region: Isochorismatase; pfam00857
158879005885	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
158879005886	catalytic triad [active]
158879005887	conserved cis-peptide bond; other site
158879005888	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
158879005889	DHH family; Region: DHH; pfam01368
158879005890	DHHA2 domain; Region: DHHA2; pfam02833
158879005891	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
158879005892	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
158879005893	NAD(P) binding site [chemical binding]; other site
158879005894	catalytic residues [active]
158879005895	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
158879005896	YolD-like protein; Region: YolD; pfam08863
158879005897	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
158879005898	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
158879005899	active site
158879005900	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
158879005901	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
158879005902	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
158879005903	Bacterial PH domain; Region: DUF304; cl01348
158879005904	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
158879005905	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
158879005906	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
158879005907	Walker A/P-loop; other site
158879005908	ATP binding site [chemical binding]; other site
158879005909	Q-loop/lid; other site
158879005910	ABC transporter signature motif; other site
158879005911	Walker B; other site
158879005912	D-loop; other site
158879005913	H-loop/switch region; other site
158879005914	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
158879005915	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
158879005916	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
158879005917	Walker A/P-loop; other site
158879005918	ATP binding site [chemical binding]; other site
158879005919	Q-loop/lid; other site
158879005920	ABC transporter signature motif; other site
158879005921	Walker B; other site
158879005922	D-loop; other site
158879005923	H-loop/switch region; other site
158879005924	Predicted transcriptional regulators [Transcription]; Region: COG1725
158879005925	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
158879005926	DNA-binding site [nucleotide binding]; DNA binding site
158879005927	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
158879005928	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
158879005929	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879005930	homodimer interface [polypeptide binding]; other site
158879005931	catalytic residue [active]
158879005932	MAP domain; Region: MAP; pfam03642
158879005933	MAP domain; Region: MAP; pfam03642
158879005934	MAP domain; Region: MAP; pfam03642
158879005935	MAP domain; Region: MAP; pfam03642
158879005936	MAP domain; Region: MAP; pfam03642
158879005937	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
158879005938	prophage phiN315
158879005939	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
158879005940	chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032
158879005941	Bacterial SH3 domain homologues; Region: SH3b; smart00287
158879005942	Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821
158879005943	CHAP domain; Region: CHAP; pfam05257
158879005944	Small integral membrane protein [Function unknown]; Region: COG5546
158879005945	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
158879005946	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879005947	Zinc finger-containing protein; Region: zf-C4H2; pfam10146
158879005948	Ligand-gated ion channel; Region: Lig_chan; pfam00060
158879005949	phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665
158879005950	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
158879005951	Phage tail protein; Region: Sipho_tail; cl17486
158879005952	Phage tail protein; Region: Sipho_tail; cl17486
158879005953	Phage-related minor tail protein [Function unknown]; Region: COG5280
158879005954	Phage-related protein [Function unknown]; Region: COG5412
158879005955	Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606
158879005956	Peptidase family M23; Region: Peptidase_M23; pfam01551
158879005957	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
158879005958	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
158879005959	N-acetyl-D-glucosamine binding site [chemical binding]; other site
158879005960	catalytic residue [active]
158879005961	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
158879005962	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
158879005963	Translocation protein Sec62; Region: Sec62; cl02170
158879005964	Phage capsid family; Region: Phage_capsid; pfam05065
158879005965	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
158879005966	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
158879005967	oligomer interface [polypeptide binding]; other site
158879005968	active site residues [active]
158879005969	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
158879005970	Phage-related protein [Function unknown]; Region: COG4695; cl01923
158879005971	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
158879005972	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
158879005973	HNH endonuclease; Region: HNH; pfam01844
158879005974	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
158879005975	Protein of unknown function (DUF1514); Region: DUF1514; pfam07438
158879005976	Transcriptional activator RinB; Region: RinB; pfam06116
158879005977	Protein of unknown function (DUF1381); Region: DUF1381; pfam07129
158879005978	dUTPase; Region: dUTPase_2; pfam08761
158879005979	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
158879005980	active site
158879005981	homodimer interface [polypeptide binding]; other site
158879005982	metal binding site [ion binding]; metal-binding site
158879005983	Protein of unknown function (DUF1024); Region: DUF1024; pfam06260
158879005984	Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194
158879005985	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
158879005986	PVL ORF-50-like family; Region: PVL_ORF50; pfam07768
158879005987	Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570
158879005988	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
158879005989	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
158879005990	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
158879005991	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
158879005992	dimer interface [polypeptide binding]; other site
158879005993	ssDNA binding site [nucleotide binding]; other site
158879005994	tetramer (dimer of dimers) interface [polypeptide binding]; other site
158879005995	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
158879005996	Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723
158879005997	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
158879005998	Protein of unknown function (DUF1108); Region: DUF1108; pfam06531
158879005999	Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655
158879006000	Protein of unknown function (DUF1270); Region: DUF1270; pfam06900
158879006001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707
158879006002	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
158879006003	Phage anti-repressor protein [Transcription]; Region: COG3561
158879006004	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645
158879006005	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
158879006006	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
158879006007	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
158879006008	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
158879006009	non-specific DNA binding site [nucleotide binding]; other site
158879006010	salt bridge; other site
158879006011	sequence-specific DNA binding site [nucleotide binding]; other site
158879006012	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
158879006013	non-specific DNA binding site [nucleotide binding]; other site
158879006014	salt bridge; other site
158879006015	sequence-specific DNA binding site [nucleotide binding]; other site
158879006016	Predicted transcriptional regulator [Transcription]; Region: COG2932
158879006017	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
158879006018	Catalytic site [active]
158879006019	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
158879006020	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
158879006021	active site
158879006022	catalytic site [active]
158879006023	substrate binding site [chemical binding]; other site
158879006024	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
158879006025	active site
158879006026	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
158879006027	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
158879006028	Int/Topo IB signature motif; other site
158879006029	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
158879006030	putative catalytic site [active]
158879006031	phosphate binding site [ion binding]; other site
158879006032	metal binding site A [ion binding]; metal-binding site
158879006033	metal binding site C [ion binding]; metal-binding site
158879006034	metal binding site B [ion binding]; metal-binding site
158879006035	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
158879006036	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
158879006037	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
158879006038	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
158879006039	metal binding site [ion binding]; metal-binding site
158879006040	dimer interface [polypeptide binding]; other site
158879006041	Cation transport protein; Region: TrkH; cl17365
158879006042	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
158879006043	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
158879006044	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879006045	Pathogenicity island SaPIn1
158879006046	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
158879006047	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879006048	superantigen-like protein; Reviewed; Region: PRK13350
158879006049	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
158879006050	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
158879006051	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
158879006052	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
158879006053	hydrolase, hydrolyzing O-glycosyl compounds; Region: PLN02219; cl14104
158879006054	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
158879006055	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
158879006056	Protein of unknown function (DUF1474); Region: DUF1474; pfam07342
158879006057	DNA binding domain, excisionase family; Region: excise; TIGR01764
158879006058	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
158879006059	non-specific DNA binding site [nucleotide binding]; other site
158879006060	salt bridge; other site
158879006061	sequence-specific DNA binding site [nucleotide binding]; other site
158879006062	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
158879006063	non-specific DNA binding site [nucleotide binding]; other site
158879006064	salt bridge; other site
158879006065	sequence-specific DNA binding site [nucleotide binding]; other site
158879006066	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
158879006067	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
158879006068	Int/Topo IB signature motif; other site
158879006069	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
158879006070	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
158879006071	ring oligomerisation interface [polypeptide binding]; other site
158879006072	ATP/Mg binding site [chemical binding]; other site
158879006073	stacking interactions; other site
158879006074	hinge regions; other site
158879006075	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
158879006076	oligomerisation interface [polypeptide binding]; other site
158879006077	mobile loop; other site
158879006078	roof hairpin; other site
158879006079	CAAX protease self-immunity; Region: Abi; pfam02517
158879006080	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
158879006081	dimer interface [polypeptide binding]; other site
158879006082	FMN binding site [chemical binding]; other site
158879006083	Predicted amidohydrolase [General function prediction only]; Region: COG0388
158879006084	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
158879006085	putative active site [active]
158879006086	catalytic triad [active]
158879006087	putative dimer interface [polypeptide binding]; other site
158879006088	delta-hemolysin; Provisional; Region: PRK14752
158879006089	Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription]; Region: AgrB; COG4512
158879006090	Staphylococcal AgrD protein; Region: AgrD; pfam05931
158879006091	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
158879006092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879006093	Mg2+ binding site [ion binding]; other site
158879006094	G-X-G motif; other site
158879006095	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
158879006096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879006097	active site
158879006098	phosphorylation site [posttranslational modification]
158879006099	intermolecular recognition site; other site
158879006100	dimerization interface [polypeptide binding]; other site
158879006101	LytTr DNA-binding domain; Region: LytTR; pfam04397
158879006102	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
158879006103	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
158879006104	putative substrate binding site [chemical binding]; other site
158879006105	putative ATP binding site [chemical binding]; other site
158879006106	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
158879006107	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
158879006108	substrate binding [chemical binding]; other site
158879006109	active site
158879006110	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
158879006111	Transcriptional regulators [Transcription]; Region: PurR; COG1609
158879006112	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
158879006113	DNA binding site [nucleotide binding]
158879006114	domain linker motif; other site
158879006115	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
158879006116	dimerization interface [polypeptide binding]; other site
158879006117	ligand binding site [chemical binding]; other site
158879006118	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
158879006119	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
158879006120	CPxP  motif; other site
158879006121	Predicted transporter component [General function prediction only]; Region: COG2391
158879006122	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
158879006123	Sulphur transport; Region: Sulf_transp; pfam04143
158879006124	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
158879006125	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
158879006126	CoA binding domain; Region: CoA_binding; pfam02629
158879006127	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
158879006128	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
158879006129	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
158879006130	ABC transporter; Region: ABC_tran_2; pfam12848
158879006131	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
158879006132	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
158879006133	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
158879006134	Walker A/P-loop; other site
158879006135	ATP binding site [chemical binding]; other site
158879006136	Q-loop/lid; other site
158879006137	ABC transporter signature motif; other site
158879006138	Walker B; other site
158879006139	D-loop; other site
158879006140	H-loop/switch region; other site
158879006141	UGMP family protein; Validated; Region: PRK09604
158879006142	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
158879006143	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
158879006144	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879006145	Coenzyme A binding pocket [chemical binding]; other site
158879006146	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
158879006147	Glycoprotease family; Region: Peptidase_M22; pfam00814
158879006148	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
158879006149	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
158879006150	6-phosphogluconate dehydratase; Region: edd; TIGR01196
158879006151	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
158879006152	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
158879006153	PYR/PP interface [polypeptide binding]; other site
158879006154	dimer interface [polypeptide binding]; other site
158879006155	TPP binding site [chemical binding]; other site
158879006156	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
158879006157	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
158879006158	TPP-binding site [chemical binding]; other site
158879006159	dimer interface [polypeptide binding]; other site
158879006160	acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562
158879006161	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
158879006162	ketol-acid reductoisomerase; Provisional; Region: PRK05479
158879006163	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
158879006164	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
158879006165	2-isopropylmalate synthase; Validated; Region: PRK00915
158879006166	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
158879006167	active site
158879006168	catalytic residues [active]
158879006169	metal binding site [ion binding]; metal-binding site
158879006170	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
158879006171	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
158879006172	tartrate dehydrogenase; Region: TTC; TIGR02089
158879006173	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
158879006174	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
158879006175	substrate binding site [chemical binding]; other site
158879006176	ligand binding site [chemical binding]; other site
158879006177	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
158879006178	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
158879006179	substrate binding site [chemical binding]; other site
158879006180	threonine dehydratase; Validated; Region: PRK08639
158879006181	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
158879006182	tetramer interface [polypeptide binding]; other site
158879006183	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879006184	catalytic residue [active]
158879006185	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
158879006186	putative Ile/Val binding site [chemical binding]; other site
158879006187	hypothetical protein; Provisional; Region: PRK04351
158879006188	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
158879006189	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
158879006190	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
158879006191	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
158879006192	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
158879006193	RNA binding site [nucleotide binding]; other site
158879006194	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
158879006195	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
158879006196	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
158879006197	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
158879006198	DNA binding residues [nucleotide binding]
158879006199	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
158879006200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879006201	ATP binding site [chemical binding]; other site
158879006202	Mg2+ binding site [ion binding]; other site
158879006203	G-X-G motif; other site
158879006204	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
158879006205	anti sigma factor interaction site; other site
158879006206	regulatory phosphorylation site [posttranslational modification]; other site
158879006207	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
158879006208	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
158879006209	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
158879006210	PemK-like protein; Region: PemK; pfam02452
158879006211	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
158879006212	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
158879006213	active site
158879006214	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
158879006215	dimer interface [polypeptide binding]; other site
158879006216	substrate binding site [chemical binding]; other site
158879006217	catalytic residues [active]
158879006218	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
158879006219	Uncharacterized conserved protein [Function unknown]; Region: COG3402
158879006220	Predicted membrane protein [Function unknown]; Region: COG3428
158879006221	Bacterial PH domain; Region: DUF304; pfam03703
158879006222	Bacterial PH domain; Region: DUF304; pfam03703
158879006223	Bacterial PH domain; Region: DUF304; cl01348
158879006224	potassium-transporting ATPase subunit C; Provisional; Region: PRK13998
158879006225	High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216
158879006226	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
158879006227	Soluble P-type ATPase [General function prediction only]; Region: COG4087
158879006228	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060
158879006229	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
158879006230	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
158879006231	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
158879006232	Ligand Binding Site [chemical binding]; other site
158879006233	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
158879006234	dimer interface [polypeptide binding]; other site
158879006235	phosphorylation site [posttranslational modification]
158879006236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879006237	ATP binding site [chemical binding]; other site
158879006238	Mg2+ binding site [ion binding]; other site
158879006239	G-X-G motif; other site
158879006240	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
158879006241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879006242	active site
158879006243	phosphorylation site [posttranslational modification]
158879006244	intermolecular recognition site; other site
158879006245	dimerization interface [polypeptide binding]; other site
158879006246	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
158879006247	DNA binding site [nucleotide binding]
158879006248	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
158879006249	Transposase; Region: DDE_Tnp_ISL3; pfam01610
158879006250	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
158879006251	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
158879006252	ATP binding site [chemical binding]; other site
158879006253	Mg++ binding site [ion binding]; other site
158879006254	motif III; other site
158879006255	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
158879006256	nucleotide binding region [chemical binding]; other site
158879006257	ATP-binding site [chemical binding]; other site
158879006258	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
158879006259	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
158879006260	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
158879006261	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
158879006262	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
158879006263	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
158879006264	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
158879006265	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
158879006266	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
158879006267	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
158879006268	putative homodimer interface [polypeptide binding]; other site
158879006269	putative homotetramer interface [polypeptide binding]; other site
158879006270	allosteric switch controlling residues; other site
158879006271	putative metal binding site [ion binding]; other site
158879006272	putative homodimer-homodimer interface [polypeptide binding]; other site
158879006273	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
158879006274	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
158879006275	putative active site [active]
158879006276	catalytic site [active]
158879006277	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
158879006278	putative active site [active]
158879006279	catalytic site [active]
158879006280	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
158879006281	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
158879006282	Zn2+ binding site [ion binding]; other site
158879006283	Mg2+ binding site [ion binding]; other site
158879006284	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
158879006285	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
158879006286	thiamine phosphate binding site [chemical binding]; other site
158879006287	active site
158879006288	pyrophosphate binding site [ion binding]; other site
158879006289	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
158879006290	substrate binding site [chemical binding]; other site
158879006291	multimerization interface [polypeptide binding]; other site
158879006292	ATP binding site [chemical binding]; other site
158879006293	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
158879006294	dimer interface [polypeptide binding]; other site
158879006295	substrate binding site [chemical binding]; other site
158879006296	ATP binding site [chemical binding]; other site
158879006297	thiaminase II; Region: salvage_TenA; TIGR04306
158879006298	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
158879006299	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
158879006300	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
158879006301	dimer interface [polypeptide binding]; other site
158879006302	ssDNA binding site [nucleotide binding]; other site
158879006303	tetramer (dimer of dimers) interface [polypeptide binding]; other site
158879006304	YwpF-like protein; Region: YwpF; pfam14183
158879006305	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
158879006306	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
158879006307	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
158879006308	hinge; other site
158879006309	active site
158879006310	Predicted membrane protein [Function unknown]; Region: COG4836
158879006311	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735
158879006312	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
158879006313	gamma subunit interface [polypeptide binding]; other site
158879006314	epsilon subunit interface [polypeptide binding]; other site
158879006315	LBP interface [polypeptide binding]; other site
158879006316	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
158879006317	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
158879006318	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
158879006319	alpha subunit interaction interface [polypeptide binding]; other site
158879006320	Walker A motif; other site
158879006321	ATP binding site [chemical binding]; other site
158879006322	Walker B motif; other site
158879006323	inhibitor binding site; inhibition site
158879006324	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
158879006325	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
158879006326	core domain interface [polypeptide binding]; other site
158879006327	delta subunit interface [polypeptide binding]; other site
158879006328	epsilon subunit interface [polypeptide binding]; other site
158879006329	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
158879006330	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
158879006331	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
158879006332	beta subunit interaction interface [polypeptide binding]; other site
158879006333	Walker A motif; other site
158879006334	ATP binding site [chemical binding]; other site
158879006335	Walker B motif; other site
158879006336	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
158879006337	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
158879006338	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
158879006339	F0F1 ATP synthase subunit B; Provisional; Region: PRK13453
158879006340	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
158879006341	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
158879006342	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
158879006343	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
158879006344	Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468
158879006345	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
158879006346	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
158879006347	active site
158879006348	homodimer interface [polypeptide binding]; other site
158879006349	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
158879006350	active site
158879006351	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
158879006352	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
158879006353	dimer interface [polypeptide binding]; other site
158879006354	active site
158879006355	glycine-pyridoxal phosphate binding site [chemical binding]; other site
158879006356	folate binding site [chemical binding]; other site
158879006357	hypothetical protein; Provisional; Region: PRK13690
158879006358	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
158879006359	Low molecular weight phosphatase family; Region: LMWPc; cd00115
158879006360	active site
158879006361	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
158879006362	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
158879006363	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
158879006364	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879006365	S-adenosylmethionine binding site [chemical binding]; other site
158879006366	peptide chain release factor 1; Validated; Region: prfA; PRK00591
158879006367	This domain is found in peptide chain release factors; Region: PCRF; smart00937
158879006368	RF-1 domain; Region: RF-1; pfam00472
158879006369	thymidine kinase; Provisional; Region: PRK04296
158879006370	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
158879006371	transcription termination factor Rho; Provisional; Region: rho; PRK09376
158879006372	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
158879006373	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
158879006374	RNA binding site [nucleotide binding]; other site
158879006375	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
158879006376	multimer interface [polypeptide binding]; other site
158879006377	Walker A motif; other site
158879006378	ATP binding site [chemical binding]; other site
158879006379	Walker B motif; other site
158879006380	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
158879006381	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
158879006382	NAD binding site [chemical binding]; other site
158879006383	catalytic residues [active]
158879006384	Predicted transcriptional regulators [Transcription]; Region: COG1733
158879006385	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
158879006386	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
158879006387	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
158879006388	hinge; other site
158879006389	active site
158879006390	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
158879006391	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
158879006392	intersubunit interface [polypeptide binding]; other site
158879006393	active site
158879006394	zinc binding site [ion binding]; other site
158879006395	Na+ binding site [ion binding]; other site
158879006396	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
158879006397	CTP synthetase; Validated; Region: pyrG; PRK05380
158879006398	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
158879006399	Catalytic site [active]
158879006400	active site
158879006401	UTP binding site [chemical binding]; other site
158879006402	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
158879006403	active site
158879006404	putative oxyanion hole; other site
158879006405	catalytic triad [active]
158879006406	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
158879006407	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879006408	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
158879006409	Coenzyme A binding pocket [chemical binding]; other site
158879006410	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
158879006411	Coenzyme A binding pocket [chemical binding]; other site
158879006412	pantothenate kinase; Provisional; Region: PRK13317
158879006413	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
158879006414	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
158879006415	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
158879006416	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
158879006417	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
158879006418	metal binding site [ion binding]; metal-binding site
158879006419	S-ribosylhomocysteinase; Provisional; Region: PRK02260
158879006420	Predicted membrane protein [Function unknown]; Region: COG4270
158879006421	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
158879006422	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
158879006423	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
158879006424	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
158879006425	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
158879006426	intersubunit interface [polypeptide binding]; other site
158879006427	active site
158879006428	catalytic residue [active]
158879006429	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
158879006430	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
158879006431	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
158879006432	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
158879006433	dimerization interface [polypeptide binding]; other site
158879006434	DPS ferroxidase diiron center [ion binding]; other site
158879006435	ion pore; other site
158879006436	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
158879006437	EVE domain; Region: EVE; cl00728
158879006438	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
158879006439	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
158879006440	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
158879006441	NADH(P)-binding; Region: NAD_binding_10; pfam13460
158879006442	NAD(P) binding site [chemical binding]; other site
158879006443	putative active site [active]
158879006444	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
158879006445	dimerization interface [polypeptide binding]; other site
158879006446	putative DNA binding site [nucleotide binding]; other site
158879006447	putative Zn2+ binding site [ion binding]; other site
158879006448	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
158879006449	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
158879006450	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879006451	S-adenosylmethionine binding site [chemical binding]; other site
158879006452	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
158879006453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879006454	S-adenosylmethionine binding site [chemical binding]; other site
158879006455	aminoglycoside resistance protein; Provisional; Region: PRK13746
158879006456	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
158879006457	active site
158879006458	NTP binding site [chemical binding]; other site
158879006459	metal binding triad [ion binding]; metal-binding site
158879006460	antibiotic binding site [chemical binding]; other site
158879006461	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
158879006462	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
158879006463	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
158879006464	Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195
158879006465	Int/Topo IB signature motif; other site
158879006466	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
158879006467	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
158879006468	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
158879006469	Int/Topo IB signature motif; other site
158879006470	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
158879006471	Cytoadherence-linked asexual protein; Region: CLAG; pfam03805
158879006472	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
158879006473	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
158879006474	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879006475	active site
158879006476	motif I; other site
158879006477	motif II; other site
158879006478	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879006479	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
158879006480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
158879006481	Walker A/P-loop; other site
158879006482	ATP binding site [chemical binding]; other site
158879006483	Q-loop/lid; other site
158879006484	ABC transporter signature motif; other site
158879006485	Walker B; other site
158879006486	D-loop; other site
158879006487	H-loop/switch region; other site
158879006488	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
158879006489	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
158879006490	glutaminase active site [active]
158879006491	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
158879006492	dimer interface [polypeptide binding]; other site
158879006493	active site
158879006494	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
158879006495	dimer interface [polypeptide binding]; other site
158879006496	active site
158879006497	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
158879006498	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
158879006499	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
158879006500	active site
158879006501	P-loop; other site
158879006502	phosphorylation site [posttranslational modification]
158879006503	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
158879006504	HTH domain; Region: HTH_11; pfam08279
158879006505	Mga helix-turn-helix domain; Region: Mga; pfam05043
158879006506	PRD domain; Region: PRD; pfam00874
158879006507	PRD domain; Region: PRD; pfam00874
158879006508	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
158879006509	active site
158879006510	P-loop; other site
158879006511	phosphorylation site [posttranslational modification]
158879006512	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
158879006513	active site
158879006514	phosphorylation site [posttranslational modification]
158879006515	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
158879006516	active site
158879006517	phosphorylation site [posttranslational modification]
158879006518	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
158879006519	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
158879006520	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
158879006521	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
158879006522	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
158879006523	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879006524	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879006525	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879006526	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879006527	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879006528	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879006529	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
158879006530	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
158879006531	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
158879006532	active site
158879006533	substrate binding site [chemical binding]; other site
158879006534	metal binding site [ion binding]; metal-binding site
158879006535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
158879006536	YbbR-like protein; Region: YbbR; pfam07949
158879006537	TIGR00159 family protein; Region: TIGR00159
158879006538	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
158879006539	Arginase family; Region: Arginase; cd09989
158879006540	active site
158879006541	Mn binding site [ion binding]; other site
158879006542	oligomer interface [polypeptide binding]; other site
158879006543	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
158879006544	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
158879006545	Walker A motif; other site
158879006546	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879006547	Major Facilitator Superfamily; Region: MFS_1; pfam07690
158879006548	putative substrate translocation pore; other site
158879006549	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879006550	Major Facilitator Superfamily; Region: MFS_1; pfam07690
158879006551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879006552	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
158879006553	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
158879006554	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
158879006555	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
158879006556	substrate binding site; other site
158879006557	dimerization interface; other site
158879006558	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
158879006559	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
158879006560	Nucleoside recognition; Region: Gate; pfam07670
158879006561	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
158879006562	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
158879006563	ABC-ATPase subunit  interface; other site
158879006564	dimer interface [polypeptide binding]; other site
158879006565	putative PBP binding regions; other site
158879006566	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
158879006567	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
158879006568	ABC-ATPase subunit  interface; other site
158879006569	dimer interface [polypeptide binding]; other site
158879006570	putative PBP binding regions; other site
158879006571	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
158879006572	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
158879006573	siderophore binding site; other site
158879006574	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
158879006575	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
158879006576	dimer interface [polypeptide binding]; other site
158879006577	active site
158879006578	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
158879006579	substrate binding site [chemical binding]; other site
158879006580	catalytic residue [active]
158879006581	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
158879006582	IucA / IucC family; Region: IucA_IucC; pfam04183
158879006583	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
158879006584	H+ Antiporter protein; Region: 2A0121; TIGR00900
158879006585	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879006586	putative substrate translocation pore; other site
158879006587	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
158879006588	IucA / IucC family; Region: IucA_IucC; pfam04183
158879006589	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
158879006590	Asp23 family; Region: Asp23; pfam03780
158879006591	Small integral membrane protein [Function unknown]; Region: COG5547
158879006592	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
158879006593	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
158879006594	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
158879006595	putative NAD(P) binding site [chemical binding]; other site
158879006596	dimer interface [polypeptide binding]; other site
158879006597	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
158879006598	Prostaglandin dehydrogenases; Region: PGDH; cd05288
158879006599	NAD(P) binding site [chemical binding]; other site
158879006600	substrate binding site [chemical binding]; other site
158879006601	dimer interface [polypeptide binding]; other site
158879006602	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
158879006603	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
158879006604	beta-galactosidase; Region: BGL; TIGR03356
158879006605	phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
158879006606	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
158879006607	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
158879006608	active site
158879006609	P-loop; other site
158879006610	phosphorylation site [posttranslational modification]
158879006611	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
158879006612	methionine cluster; other site
158879006613	active site
158879006614	phosphorylation site [posttranslational modification]
158879006615	metal binding site [ion binding]; metal-binding site
158879006616	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
158879006617	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
158879006618	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
158879006619	putative substrate binding site [chemical binding]; other site
158879006620	putative ATP binding site [chemical binding]; other site
158879006621	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
158879006622	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
158879006623	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
158879006624	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
158879006625	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
158879006626	NAD-dependent deacetylase; Provisional; Region: PRK00481
158879006627	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
158879006628	NAD+ binding site [chemical binding]; other site
158879006629	substrate binding site [chemical binding]; other site
158879006630	putative Zn binding site [ion binding]; other site
158879006631	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
158879006632	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
158879006633	active site
158879006634	catalytic tetrad [active]
158879006635	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
158879006636	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
158879006637	DNA binding residues [nucleotide binding]
158879006638	putative dimer interface [polypeptide binding]; other site
158879006639	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
158879006640	substrate binding site [chemical binding]; other site
158879006641	catalytic residues [active]
158879006642	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
158879006643	Peptidase family M23; Region: Peptidase_M23; pfam01551
158879006644	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
158879006645	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
158879006646	active site
158879006647	motif I; other site
158879006648	motif II; other site
158879006649	MAP domain; Region: MAP; pfam03642
158879006650	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
158879006651	acetolactate synthase; Reviewed; Region: PRK08617
158879006652	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
158879006653	PYR/PP interface [polypeptide binding]; other site
158879006654	dimer interface [polypeptide binding]; other site
158879006655	TPP binding site [chemical binding]; other site
158879006656	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
158879006657	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
158879006658	TPP-binding site [chemical binding]; other site
158879006659	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
158879006660	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
158879006661	putative active site [active]
158879006662	putative NTP binding site [chemical binding]; other site
158879006663	putative nucleic acid binding site [nucleotide binding]; other site
158879006664	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
158879006665	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
158879006666	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
158879006667	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
158879006668	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
158879006669	23S rRNA interface [nucleotide binding]; other site
158879006670	L3 interface [polypeptide binding]; other site
158879006671	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
158879006672	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
158879006673	dimerization interface 3.5A [polypeptide binding]; other site
158879006674	active site
158879006675	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
158879006676	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646
158879006677	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
158879006678	Walker A/P-loop; other site
158879006679	ATP binding site [chemical binding]; other site
158879006680	Q-loop/lid; other site
158879006681	ABC transporter signature motif; other site
158879006682	Walker B; other site
158879006683	D-loop; other site
158879006684	H-loop/switch region; other site
158879006685	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648
158879006686	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
158879006687	Walker A/P-loop; other site
158879006688	ATP binding site [chemical binding]; other site
158879006689	Q-loop/lid; other site
158879006690	ABC transporter signature motif; other site
158879006691	Walker B; other site
158879006692	D-loop; other site
158879006693	H-loop/switch region; other site
158879006694	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
158879006695	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
158879006696	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
158879006697	alphaNTD homodimer interface [polypeptide binding]; other site
158879006698	alphaNTD - beta interaction site [polypeptide binding]; other site
158879006699	alphaNTD - beta' interaction site [polypeptide binding]; other site
158879006700	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
158879006701	30S ribosomal protein S11; Validated; Region: PRK05309
158879006702	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
158879006703	30S ribosomal protein S13; Region: bact_S13; TIGR03631
158879006704	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
158879006705	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
158879006706	rRNA binding site [nucleotide binding]; other site
158879006707	predicted 30S ribosome binding site; other site
158879006708	adenylate kinase; Reviewed; Region: adk; PRK00279
158879006709	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
158879006710	AMP-binding site [chemical binding]; other site
158879006711	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
158879006712	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
158879006713	SecY translocase; Region: SecY; pfam00344
158879006714	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
158879006715	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
158879006716	23S rRNA binding site [nucleotide binding]; other site
158879006717	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
158879006718	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
158879006719	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
158879006720	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
158879006721	5S rRNA interface [nucleotide binding]; other site
158879006722	L27 interface [polypeptide binding]; other site
158879006723	23S rRNA interface [nucleotide binding]; other site
158879006724	L5 interface [polypeptide binding]; other site
158879006725	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
158879006726	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
158879006727	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
158879006728	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
158879006729	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
158879006730	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
158879006731	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
158879006732	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
158879006733	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
158879006734	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
158879006735	RNA binding site [nucleotide binding]; other site
158879006736	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
158879006737	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
158879006738	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
158879006739	23S rRNA interface [nucleotide binding]; other site
158879006740	putative translocon interaction site; other site
158879006741	signal recognition particle (SRP54) interaction site; other site
158879006742	L23 interface [polypeptide binding]; other site
158879006743	trigger factor interaction site; other site
158879006744	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
158879006745	23S rRNA interface [nucleotide binding]; other site
158879006746	5S rRNA interface [nucleotide binding]; other site
158879006747	putative antibiotic binding site [chemical binding]; other site
158879006748	L25 interface [polypeptide binding]; other site
158879006749	L27 interface [polypeptide binding]; other site
158879006750	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
158879006751	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
158879006752	G-X-X-G motif; other site
158879006753	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
158879006754	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
158879006755	putative translocon binding site; other site
158879006756	protein-rRNA interface [nucleotide binding]; other site
158879006757	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
158879006758	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
158879006759	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
158879006760	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
158879006761	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
158879006762	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
158879006763	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
158879006764	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
158879006765	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
158879006766	DNA topoisomerase III; Provisional; Region: PRK07726
158879006767	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
158879006768	active site
158879006769	putative interdomain interaction site [polypeptide binding]; other site
158879006770	putative metal-binding site [ion binding]; other site
158879006771	putative nucleotide binding site [chemical binding]; other site
158879006772	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
158879006773	domain I; other site
158879006774	DNA binding groove [nucleotide binding]
158879006775	phosphate binding site [ion binding]; other site
158879006776	domain II; other site
158879006777	domain III; other site
158879006778	nucleotide binding site [chemical binding]; other site
158879006779	catalytic site [active]
158879006780	domain IV; other site
158879006781	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
158879006782	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879006783	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
158879006784	Coenzyme A binding pocket [chemical binding]; other site
158879006785	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
158879006786	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
158879006787	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
158879006788	Predicted permeases [General function prediction only]; Region: COG0679
158879006789	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
158879006790	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
158879006791	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
158879006792	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
158879006793	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
158879006794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879006795	Major Facilitator Superfamily; Region: MFS_1; pfam07690
158879006796	putative substrate translocation pore; other site
158879006797	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
158879006798	Transcriptional regulators [Transcription]; Region: MarR; COG1846
158879006799	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
158879006800	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
158879006801	FeS/SAM binding site; other site
158879006802	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
158879006803	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
158879006804	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
158879006805	GTP binding site; other site
158879006806	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
158879006807	MoaE interaction surface [polypeptide binding]; other site
158879006808	MoeB interaction surface [polypeptide binding]; other site
158879006809	thiocarboxylated glycine; other site
158879006810	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
158879006811	MoaE homodimer interface [polypeptide binding]; other site
158879006812	MoaD interaction [polypeptide binding]; other site
158879006813	active site residues [active]
158879006814	Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763
158879006815	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
158879006816	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
158879006817	dimer interface [polypeptide binding]; other site
158879006818	putative functional site; other site
158879006819	putative MPT binding site; other site
158879006820	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
158879006821	trimer interface [polypeptide binding]; other site
158879006822	dimer interface [polypeptide binding]; other site
158879006823	putative active site [active]
158879006824	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
158879006825	MPT binding site; other site
158879006826	trimer interface [polypeptide binding]; other site
158879006827	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
158879006828	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
158879006829	ATP binding site [chemical binding]; other site
158879006830	substrate interface [chemical binding]; other site
158879006831	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
158879006832	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
158879006833	Walker A/P-loop; other site
158879006834	ATP binding site [chemical binding]; other site
158879006835	Q-loop/lid; other site
158879006836	ABC transporter signature motif; other site
158879006837	Walker B; other site
158879006838	D-loop; other site
158879006839	H-loop/switch region; other site
158879006840	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
158879006841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879006842	dimer interface [polypeptide binding]; other site
158879006843	conserved gate region; other site
158879006844	putative PBP binding loops; other site
158879006845	ABC-ATPase subunit interface; other site
158879006846	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
158879006847	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
158879006848	substrate binding pocket [chemical binding]; other site
158879006849	membrane-bound complex binding site; other site
158879006850	hinge residues; other site
158879006851	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
158879006852	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879006853	Coenzyme A binding pocket [chemical binding]; other site
158879006854	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
158879006855	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
158879006856	active site
158879006857	dimerization interface [polypeptide binding]; other site
158879006858	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
158879006859	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
158879006860	intersubunit interface [polypeptide binding]; other site
158879006861	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
158879006862	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
158879006863	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
158879006864	Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
158879006865	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
158879006866	alpha-gamma subunit interface [polypeptide binding]; other site
158879006867	beta-gamma subunit interface [polypeptide binding]; other site
158879006868	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
158879006869	gamma-beta subunit interface [polypeptide binding]; other site
158879006870	alpha-beta subunit interface [polypeptide binding]; other site
158879006871	urease subunit alpha; Reviewed; Region: ureC; PRK13207
158879006872	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
158879006873	subunit interactions [polypeptide binding]; other site
158879006874	active site
158879006875	flap region; other site
158879006876	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
158879006877	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
158879006878	dimer interface [polypeptide binding]; other site
158879006879	catalytic residues [active]
158879006880	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
158879006881	UreF; Region: UreF; pfam01730
158879006882	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
158879006883	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
158879006884	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
158879006885	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
158879006886	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
158879006887	Transcriptional regulators [Transcription]; Region: MarR; COG1846
158879006888	Helix-turn-helix domain; Region: HTH_18; pfam12833
158879006889	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
158879006890	Surface antigen [General function prediction only]; Region: COG3942
158879006891	CHAP domain; Region: CHAP; pfam05257
158879006892	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
158879006893	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
158879006894	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
158879006895	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
158879006896	Surface antigen [General function prediction only]; Region: COG3942
158879006897	CHAP domain; Region: CHAP; pfam05257
158879006898	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
158879006899	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
158879006900	putative ligand binding site [chemical binding]; other site
158879006901	putative NAD binding site [chemical binding]; other site
158879006902	catalytic site [active]
158879006903	hypothetical protein; Provisional; Region: PRK06753
158879006904	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
158879006905	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
158879006906	Lysozyme subfamily 2; Region: LYZ2; smart00047
158879006907	Uncharacterized conserved protein [Function unknown]; Region: COG2427
158879006908	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
158879006909	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
158879006910	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
158879006911	4Fe-4S binding domain; Region: Fer4; pfam00037
158879006912	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
158879006913	[4Fe-4S] binding site [ion binding]; other site
158879006914	molybdopterin cofactor binding site; other site
158879006915	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
158879006916	molybdopterin cofactor binding site; other site
158879006917	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
158879006918	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
158879006919	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
158879006920	active site
158879006921	Predicted transcriptional regulator [Transcription]; Region: COG2378
158879006922	HTH domain; Region: HTH_11; pfam08279
158879006923	CAAX protease self-immunity; Region: Abi; pfam02517
158879006924	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
158879006925	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
158879006926	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
158879006927	putative active site [active]
158879006928	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
158879006929	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
158879006930	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879006931	active site
158879006932	motif I; other site
158879006933	motif II; other site
158879006934	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
158879006935	Sodium Bile acid symporter family; Region: SBF; pfam01758
158879006936	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
158879006937	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
158879006938	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
158879006939	active site turn [active]
158879006940	phosphorylation site [posttranslational modification]
158879006941	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
158879006942	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
158879006943	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
158879006944	putative active site [active]
158879006945	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
158879006946	putative hydrophobic ligand binding site [chemical binding]; other site
158879006947	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
158879006948	oxidoreductase; Provisional; Region: PRK07985
158879006949	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
158879006950	NAD(P) binding site [chemical binding]; other site
158879006951	active site
158879006952	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
158879006953	amidohydrolase; Region: amidohydrolases; TIGR01891
158879006954	metal binding site [ion binding]; metal-binding site
158879006955	dimer interface [polypeptide binding]; other site
158879006956	imidazolonepropionase; Validated; Region: PRK09356
158879006957	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
158879006958	active site
158879006959	urocanate hydratase; Provisional; Region: PRK05414
158879006960	Transcriptional regulator [Transcription]; Region: LysR; COG0583
158879006961	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
158879006962	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
158879006963	dimerization interface [polypeptide binding]; other site
158879006964	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
158879006965	FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363
158879006966	putative active site [active]
158879006967	putative Mg binding site [ion binding]; other site
158879006968	formimidoylglutamase; Provisional; Region: PRK13775
158879006969	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
158879006970	putative active site [active]
158879006971	putative metal binding site [ion binding]; other site
158879006972	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
158879006973	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
158879006974	tetramer (dimer of dimers) interface [polypeptide binding]; other site
158879006975	active site
158879006976	dimer interface [polypeptide binding]; other site
158879006977	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
158879006978	MOSC domain; Region: MOSC; pfam03473
158879006979	3-alpha domain; Region: 3-alpha; pfam03475
158879006980	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
158879006981	active site
158879006982	catalytic residues [active]
158879006983	Uncharacterized conserved protein [Function unknown]; Region: COG1742
158879006984	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
158879006985	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
158879006986	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
158879006987	Walker A/P-loop; other site
158879006988	ATP binding site [chemical binding]; other site
158879006989	Q-loop/lid; other site
158879006990	ABC transporter signature motif; other site
158879006991	Walker B; other site
158879006992	D-loop; other site
158879006993	H-loop/switch region; other site
158879006994	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
158879006995	Predicted membrane protein [Function unknown]; Region: COG3152
158879006996	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
158879006997	active site
158879006998	DNA binding site [nucleotide binding]
158879006999	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
158879007000	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
158879007001	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
158879007002	homotetramer interface [polypeptide binding]; other site
158879007003	FMN binding site [chemical binding]; other site
158879007004	homodimer contacts [polypeptide binding]; other site
158879007005	putative active site [active]
158879007006	putative substrate binding site [chemical binding]; other site
158879007007	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
158879007008	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
158879007009	oligomer interface [polypeptide binding]; other site
158879007010	metal binding site [ion binding]; metal-binding site
158879007011	metal binding site [ion binding]; metal-binding site
158879007012	putative Cl binding site [ion binding]; other site
158879007013	aspartate ring; other site
158879007014	basic sphincter; other site
158879007015	hydrophobic gate; other site
158879007016	periplasmic entrance; other site
158879007017	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
158879007018	active site
158879007019	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
158879007020	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
158879007021	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879007022	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
158879007023	putative substrate translocation pore; other site
158879007024	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
158879007025	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
158879007026	HlyD family secretion protein; Region: HlyD_3; pfam13437
158879007027	lipoyl-biotinyl attachment site [posttranslational modification]; other site
158879007028	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
158879007029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879007030	putative substrate translocation pore; other site
158879007031	Predicted membrane protein [Function unknown]; Region: COG4640
158879007032	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
158879007033	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
158879007034	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
158879007035	putative Zn2+ binding site [ion binding]; other site
158879007036	putative DNA binding site [nucleotide binding]; other site
158879007037	Uncharacterized conserved protein [Function unknown]; Region: COG1434
158879007038	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
158879007039	putative active site [active]
158879007040	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
158879007041	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
158879007042	Walker A/P-loop; other site
158879007043	ATP binding site [chemical binding]; other site
158879007044	Q-loop/lid; other site
158879007045	ABC transporter signature motif; other site
158879007046	Walker B; other site
158879007047	D-loop; other site
158879007048	H-loop/switch region; other site
158879007049	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
158879007050	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
158879007051	FtsX-like permease family; Region: FtsX; pfam02687
158879007052	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
158879007053	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879007054	active site
158879007055	phosphorylation site [posttranslational modification]
158879007056	intermolecular recognition site; other site
158879007057	dimerization interface [polypeptide binding]; other site
158879007058	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
158879007059	DNA binding site [nucleotide binding]
158879007060	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
158879007061	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
158879007062	dimerization interface [polypeptide binding]; other site
158879007063	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
158879007064	dimer interface [polypeptide binding]; other site
158879007065	phosphorylation site [posttranslational modification]
158879007066	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879007067	ATP binding site [chemical binding]; other site
158879007068	Mg2+ binding site [ion binding]; other site
158879007069	G-X-G motif; other site
158879007070	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
158879007071	LytTr DNA-binding domain; Region: LytTR; smart00850
158879007072	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
158879007073	Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039
158879007074	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
158879007075	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
158879007076	L-lactate permease; Region: Lactate_perm; cl00701
158879007077	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
158879007078	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879007079	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
158879007080	Coenzyme A binding pocket [chemical binding]; other site
158879007081	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
158879007082	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
158879007083	NAD(P) binding site [chemical binding]; other site
158879007084	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879007085	Coenzyme A binding pocket [chemical binding]; other site
158879007086	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
158879007087	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
158879007088	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
158879007089	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
158879007090	Predicted membrane protein [Function unknown]; Region: COG1511
158879007091	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
158879007092	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
158879007093	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
158879007094	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
158879007095	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
158879007096	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
158879007097	Cl binding site [ion binding]; other site
158879007098	oligomer interface [polypeptide binding]; other site
158879007099	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
158879007100	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
158879007101	active site turn [active]
158879007102	phosphorylation site [posttranslational modification]
158879007103	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
158879007104	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
158879007105	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
158879007106	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
158879007107	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
158879007108	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
158879007109	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
158879007110	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
158879007111	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
158879007112	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
158879007113	MarR family; Region: MarR_2; pfam12802
158879007114	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
158879007115	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
158879007116	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
158879007117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879007118	putative substrate translocation pore; other site
158879007119	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504
158879007120	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
158879007121	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
158879007122	DNA binding residues [nucleotide binding]
158879007123	dimer interface [polypeptide binding]; other site
158879007124	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
158879007125	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
158879007126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879007127	active site
158879007128	phosphorylation site [posttranslational modification]
158879007129	intermolecular recognition site; other site
158879007130	dimerization interface [polypeptide binding]; other site
158879007131	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
158879007132	DNA binding residues [nucleotide binding]
158879007133	dimerization interface [polypeptide binding]; other site
158879007134	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
158879007135	Histidine kinase; Region: HisKA_3; pfam07730
158879007136	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879007137	ATP binding site [chemical binding]; other site
158879007138	Mg2+ binding site [ion binding]; other site
158879007139	G-X-G motif; other site
158879007140	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
158879007141	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
158879007142	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
158879007143	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
158879007144	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
158879007145	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
158879007146	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
158879007147	[4Fe-4S] binding site [ion binding]; other site
158879007148	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
158879007149	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
158879007150	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
158879007151	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
158879007152	molybdopterin cofactor binding site; other site
158879007153	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
158879007154	active site
158879007155	SAM binding site [chemical binding]; other site
158879007156	homodimer interface [polypeptide binding]; other site
158879007157	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
158879007158	[2Fe-2S] cluster binding site [ion binding]; other site
158879007159	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
158879007160	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
158879007161	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
158879007162	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
158879007163	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
158879007164	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
158879007165	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
158879007166	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
158879007167	putative active site [active]
158879007168	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
158879007169	active site
158879007170	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
158879007171	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879007172	Coenzyme A binding pocket [chemical binding]; other site
158879007173	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
158879007174	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
158879007175	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
158879007176	putative hydrophobic ligand binding site [chemical binding]; other site
158879007177	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
158879007178	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
158879007179	intersubunit interface [polypeptide binding]; other site
158879007180	YodA lipocalin-like domain; Region: YodA; pfam09223
158879007181	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
158879007182	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
158879007183	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
158879007184	Thioredoxin; Region: Thioredoxin_4; cl17273
158879007185	FemAB family; Region: FemAB; pfam02388
158879007186	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
158879007187	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
158879007188	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
158879007189	Walker A/P-loop; other site
158879007190	ATP binding site [chemical binding]; other site
158879007191	Q-loop/lid; other site
158879007192	ABC transporter signature motif; other site
158879007193	Walker B; other site
158879007194	D-loop; other site
158879007195	H-loop/switch region; other site
158879007196	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
158879007197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879007198	putative PBP binding loops; other site
158879007199	dimer interface [polypeptide binding]; other site
158879007200	ABC-ATPase subunit interface; other site
158879007201	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
158879007202	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
158879007203	substrate binding pocket [chemical binding]; other site
158879007204	membrane-bound complex binding site; other site
158879007205	hinge residues; other site
158879007206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879007207	Major Facilitator Superfamily; Region: MFS_1; pfam07690
158879007208	putative substrate translocation pore; other site
158879007209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879007210	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
158879007211	catalytic core [active]
158879007212	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
158879007213	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
158879007214	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
158879007215	B domain; Region: B; pfam02216
158879007216	B domain; Region: B; pfam02216
158879007217	C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621
158879007218	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
158879007219	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
158879007220	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
158879007221	Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424
158879007222	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
158879007223	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
158879007224	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
158879007225	catalytic residue [active]
158879007226	biotin synthase; Validated; Region: PRK06256
158879007227	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
158879007228	FeS/SAM binding site; other site
158879007229	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
158879007230	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
158879007231	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
158879007232	inhibitor-cofactor binding pocket; inhibition site
158879007233	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879007234	catalytic residue [active]
158879007235	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
158879007236	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
158879007237	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
158879007238	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
158879007239	Walker A/P-loop; other site
158879007240	ATP binding site [chemical binding]; other site
158879007241	Q-loop/lid; other site
158879007242	ABC transporter signature motif; other site
158879007243	Walker B; other site
158879007244	D-loop; other site
158879007245	H-loop/switch region; other site
158879007246	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
158879007247	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
158879007248	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
158879007249	Walker A/P-loop; other site
158879007250	ATP binding site [chemical binding]; other site
158879007251	Q-loop/lid; other site
158879007252	ABC transporter signature motif; other site
158879007253	Walker B; other site
158879007254	D-loop; other site
158879007255	H-loop/switch region; other site
158879007256	Predicted membrane protein [Function unknown]; Region: COG2246
158879007257	GtrA-like protein; Region: GtrA; pfam04138
158879007258	glycerate kinase; Region: TIGR00045
158879007259	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
158879007260	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
158879007261	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879007262	putative substrate translocation pore; other site
158879007263	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
158879007264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990
158879007265	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
158879007266	putative phosphoesterase; Region: acc_ester; TIGR03729
158879007267	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
158879007268	Spore germination protein; Region: Spore_permease; cl17796
158879007269	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
158879007270	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
158879007271	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
158879007272	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
158879007273	Beta-lactamase; Region: Beta-lactamase; pfam00144
158879007274	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
158879007275	extended (e) SDRs; Region: SDR_e; cd08946
158879007276	NAD(P) binding site [chemical binding]; other site
158879007277	active site
158879007278	substrate binding site [chemical binding]; other site
158879007279	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
158879007280	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
158879007281	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
158879007282	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879007283	putative substrate translocation pore; other site
158879007284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879007285	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879007286	dimer interface [polypeptide binding]; other site
158879007287	conserved gate region; other site
158879007288	ABC-ATPase subunit interface; other site
158879007289	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
158879007290	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
158879007291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879007292	dimer interface [polypeptide binding]; other site
158879007293	conserved gate region; other site
158879007294	putative PBP binding loops; other site
158879007295	ABC-ATPase subunit interface; other site
158879007296	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
158879007297	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
158879007298	Walker A/P-loop; other site
158879007299	ATP binding site [chemical binding]; other site
158879007300	Q-loop/lid; other site
158879007301	ABC transporter signature motif; other site
158879007302	Walker B; other site
158879007303	D-loop; other site
158879007304	H-loop/switch region; other site
158879007305	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
158879007306	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
158879007307	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
158879007308	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
158879007309	amino acid transporter; Region: 2A0306; TIGR00909
158879007310	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
158879007311	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
158879007312	substrate binding pocket [chemical binding]; other site
158879007313	catalytic triad [active]
158879007314	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
158879007315	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879007316	putative substrate translocation pore; other site
158879007317	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
158879007318	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
158879007319	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
158879007320	Walker A/P-loop; other site
158879007321	ATP binding site [chemical binding]; other site
158879007322	Q-loop/lid; other site
158879007323	ABC transporter signature motif; other site
158879007324	Walker B; other site
158879007325	D-loop; other site
158879007326	H-loop/switch region; other site
158879007327	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
158879007328	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
158879007329	oligomer interface [polypeptide binding]; other site
158879007330	active site
158879007331	metal binding site [ion binding]; metal-binding site
158879007332	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115
158879007333	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
158879007334	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
158879007335	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
158879007336	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
158879007337	active site
158879007338	FMN binding site [chemical binding]; other site
158879007339	substrate binding site [chemical binding]; other site
158879007340	3Fe-4S cluster binding site [ion binding]; other site
158879007341	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
158879007342	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879007343	Major Facilitator Superfamily; Region: MFS_1; pfam07690
158879007344	putative substrate translocation pore; other site
158879007345	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
158879007346	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
158879007347	Walker A/P-loop; other site
158879007348	ATP binding site [chemical binding]; other site
158879007349	Q-loop/lid; other site
158879007350	ABC transporter signature motif; other site
158879007351	Walker B; other site
158879007352	D-loop; other site
158879007353	H-loop/switch region; other site
158879007354	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
158879007355	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
158879007356	Walker A/P-loop; other site
158879007357	ATP binding site [chemical binding]; other site
158879007358	Q-loop/lid; other site
158879007359	ABC transporter signature motif; other site
158879007360	Walker B; other site
158879007361	D-loop; other site
158879007362	H-loop/switch region; other site
158879007363	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
158879007364	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
158879007365	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
158879007366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879007367	dimer interface [polypeptide binding]; other site
158879007368	conserved gate region; other site
158879007369	ABC-ATPase subunit interface; other site
158879007370	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
158879007371	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
158879007372	dimer interface [polypeptide binding]; other site
158879007373	conserved gate region; other site
158879007374	putative PBP binding loops; other site
158879007375	ABC-ATPase subunit interface; other site
158879007376	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
158879007377	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
158879007378	substrate binding site [chemical binding]; other site
158879007379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408
158879007380	Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100
158879007381	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
158879007382	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
158879007383	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
158879007384	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
158879007385	short chain dehydrogenase; Validated; Region: PRK08589
158879007386	classical (c) SDRs; Region: SDR_c; cd05233
158879007387	NAD(P) binding site [chemical binding]; other site
158879007388	active site
158879007389	AbgT putative transporter family; Region: ABG_transport; pfam03806
158879007390	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
158879007391	Uncharacterized conserved protein [Function unknown]; Region: COG2128
158879007392	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
158879007393	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
158879007394	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
158879007395	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
158879007396	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
158879007397	classical (c) SDRs; Region: SDR_c; cd05233
158879007398	NAD(P) binding site [chemical binding]; other site
158879007399	active site
158879007400	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
158879007401	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879007402	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879007403	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879007404	Protein of unknown function, DUF576; Region: DUF576; pfam04507
158879007405	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
158879007406	nucleotide binding region [chemical binding]; other site
158879007407	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
158879007408	ATP-binding site [chemical binding]; other site
158879007409	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
158879007410	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
158879007411	PLD-like domain; Region: PLDc_2; pfam13091
158879007412	putative homodimer interface [polypeptide binding]; other site
158879007413	putative active site [active]
158879007414	catalytic site [active]
158879007415	DEAD-like helicases superfamily; Region: DEXDc; smart00487
158879007416	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
158879007417	ATP binding site [chemical binding]; other site
158879007418	putative Mg++ binding site [ion binding]; other site
158879007419	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
158879007420	active site
158879007421	8-oxo-dGMP binding site [chemical binding]; other site
158879007422	nudix motif; other site
158879007423	metal binding site [ion binding]; metal-binding site
158879007424	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
158879007425	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
158879007426	active site
158879007427	substrate binding site [chemical binding]; other site
158879007428	metal binding site [ion binding]; metal-binding site
158879007429	H+ Antiporter protein; Region: 2A0121; TIGR00900
158879007430	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
158879007431	legume lectins; Region: lectin_L-type; cl14058
158879007432	homotetramer interaction site [polypeptide binding]; other site
158879007433	carbohydrate binding site [chemical binding]; other site
158879007434	metal binding site [ion binding]; metal-binding site
158879007435	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
158879007436	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
158879007437	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
158879007438	Transcriptional regulators [Transcription]; Region: MarR; COG1846
158879007439	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
158879007440	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
158879007441	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
158879007442	active site
158879007443	tetramer interface; other site
158879007444	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
158879007445	Transposase; Region: DDE_Tnp_ISL3; pfam01610
158879007446	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
158879007447	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
158879007448	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
158879007449	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
158879007450	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
158879007451	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
158879007452	GntP family permease; Region: GntP_permease; pfam02447
158879007453	fructuronate transporter; Provisional; Region: PRK10034; cl15264
158879007454	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
158879007455	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
158879007456	N- and C-terminal domain interface [polypeptide binding]; other site
158879007457	active site
158879007458	catalytic site [active]
158879007459	metal binding site [ion binding]; metal-binding site
158879007460	carbohydrate binding site [chemical binding]; other site
158879007461	ATP binding site [chemical binding]; other site
158879007462	Transcriptional regulators [Transcription]; Region: GntR; COG1802
158879007463	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
158879007464	DNA-binding site [nucleotide binding]; DNA binding site
158879007465	FCD domain; Region: FCD; pfam07729
158879007466	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
158879007467	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
158879007468	DNA binding residues [nucleotide binding]
158879007469	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
158879007470	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
158879007471	synthetase active site [active]
158879007472	NTP binding site [chemical binding]; other site
158879007473	metal binding site [ion binding]; metal-binding site
158879007474	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
158879007475	Predicted membrane protein [Function unknown]; Region: COG1289
158879007476	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
158879007477	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
158879007478	D-galactonate transporter; Region: 2A0114; TIGR00893
158879007479	putative substrate translocation pore; other site
158879007480	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
158879007481	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
158879007482	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
158879007483	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
158879007484	Walker A/P-loop; other site
158879007485	ATP binding site [chemical binding]; other site
158879007486	Q-loop/lid; other site
158879007487	ABC transporter signature motif; other site
158879007488	Walker B; other site
158879007489	D-loop; other site
158879007490	H-loop/switch region; other site
158879007491	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
158879007492	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
158879007493	Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855
158879007494	Uncharacterized membrane protein [Function unknown]; Region: COG3949
158879007495	Predicted esterase [General function prediction only]; Region: COG0400
158879007496	putative hydrolase; Provisional; Region: PRK11460
158879007497	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
158879007498	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
158879007499	Zn binding site [ion binding]; other site
158879007500	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
158879007501	Zn binding site [ion binding]; other site
158879007502	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
158879007503	MarR family; Region: MarR; pfam01047
158879007504	Predicted acetyltransferase [General function prediction only]; Region: COG2388
158879007505	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
158879007506	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
158879007507	putative metal binding site [ion binding]; other site
158879007508	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
158879007509	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
158879007510	dimer interface [polypeptide binding]; other site
158879007511	FMN binding site [chemical binding]; other site
158879007512	D-lactate dehydrogenase; Provisional; Region: PRK12480
158879007513	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
158879007514	homodimer interface [polypeptide binding]; other site
158879007515	ligand binding site [chemical binding]; other site
158879007516	NAD binding site [chemical binding]; other site
158879007517	catalytic site [active]
158879007518	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
158879007519	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
158879007520	active site
158879007521	motif I; other site
158879007522	motif II; other site
158879007523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
158879007524	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
158879007525	Walker A/P-loop; other site
158879007526	ATP binding site [chemical binding]; other site
158879007527	Q-loop/lid; other site
158879007528	ABC transporter signature motif; other site
158879007529	Walker B; other site
158879007530	D-loop; other site
158879007531	H-loop/switch region; other site
158879007532	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
158879007533	active site
158879007534	catalytic site [active]
158879007535	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
158879007536	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879007537	Coenzyme A binding pocket [chemical binding]; other site
158879007538	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
158879007539	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
158879007540	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
158879007541	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
158879007542	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
158879007543	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
158879007544	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
158879007545	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
158879007546	EamA-like transporter family; Region: EamA; pfam00892
158879007547	EamA-like transporter family; Region: EamA; pfam00892
158879007548	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
158879007549	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
158879007550	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
158879007551	catalytic residues [active]
158879007552	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
158879007553	active site
158879007554	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
158879007555	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
158879007556	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
158879007557	active site turn [active]
158879007558	phosphorylation site [posttranslational modification]
158879007559	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
158879007560	HPr interaction site; other site
158879007561	glycerol kinase (GK) interaction site [polypeptide binding]; other site
158879007562	active site
158879007563	phosphorylation site [posttranslational modification]
158879007564	pyruvate oxidase; Provisional; Region: PRK08611
158879007565	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
158879007566	PYR/PP interface [polypeptide binding]; other site
158879007567	tetramer interface [polypeptide binding]; other site
158879007568	dimer interface [polypeptide binding]; other site
158879007569	TPP binding site [chemical binding]; other site
158879007570	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
158879007571	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
158879007572	TPP-binding site [chemical binding]; other site
158879007573	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
158879007574	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
158879007575	Transcriptional regulator [Transcription]; Region: LysR; COG0583
158879007576	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
158879007577	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
158879007578	putative dimerization interface [polypeptide binding]; other site
158879007579	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
158879007580	Surface antigen [General function prediction only]; Region: COG3942
158879007581	CHAP domain; Region: CHAP; pfam05257
158879007582	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
158879007583	homodimer interface [polypeptide binding]; other site
158879007584	catalytic residues [active]
158879007585	NAD binding site [chemical binding]; other site
158879007586	substrate binding pocket [chemical binding]; other site
158879007587	flexible flap; other site
158879007588	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
158879007589	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
158879007590	dimer interface [polypeptide binding]; other site
158879007591	active site
158879007592	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
158879007593	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
158879007594	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
158879007595	DNA binding site [nucleotide binding]
158879007596	active site
158879007597	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879007598	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
158879007599	Walker A motif; other site
158879007600	ATP binding site [chemical binding]; other site
158879007601	Walker B motif; other site
158879007602	arginine finger; other site
158879007603	UvrB/uvrC motif; Region: UVR; pfam02151
158879007604	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
158879007605	Walker A motif; other site
158879007606	ATP binding site [chemical binding]; other site
158879007607	Walker B motif; other site
158879007608	arginine finger; other site
158879007609	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
158879007610	Virus attachment protein p12 family; Region: P12; pfam12669
158879007611	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
158879007612	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
158879007613	G1 box; other site
158879007614	GTP/Mg2+ binding site [chemical binding]; other site
158879007615	Switch I region; other site
158879007616	G2 box; other site
158879007617	G3 box; other site
158879007618	Switch II region; other site
158879007619	G4 box; other site
158879007620	G5 box; other site
158879007621	Nucleoside recognition; Region: Gate; pfam07670
158879007622	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
158879007623	Nucleoside recognition; Region: Gate; pfam07670
158879007624	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
158879007625	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
158879007626	methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080
158879007627	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
158879007628	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
158879007629	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
158879007630	Glutamate binding site [chemical binding]; other site
158879007631	homodimer interface [polypeptide binding]; other site
158879007632	NAD binding site [chemical binding]; other site
158879007633	catalytic residues [active]
158879007634	maltose O-acetyltransferase; Provisional; Region: PRK10092
158879007635	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
158879007636	active site
158879007637	substrate binding site [chemical binding]; other site
158879007638	trimer interface [polypeptide binding]; other site
158879007639	CoA binding site [chemical binding]; other site
158879007640	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
158879007641	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
158879007642	metal-binding site [ion binding]
158879007643	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
158879007644	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
158879007645	metal-binding site [ion binding]
158879007646	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
158879007647	Soluble P-type ATPase [General function prediction only]; Region: COG4087
158879007648	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
158879007649	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
158879007650	metal-binding site [ion binding]
158879007651	D-lactate dehydrogenase; Validated; Region: PRK08605
158879007652	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
158879007653	homodimer interface [polypeptide binding]; other site
158879007654	ligand binding site [chemical binding]; other site
158879007655	NAD binding site [chemical binding]; other site
158879007656	catalytic site [active]
158879007657	transaminase; Reviewed; Region: PRK08068
158879007658	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
158879007659	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879007660	homodimer interface [polypeptide binding]; other site
158879007661	catalytic residue [active]
158879007662	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
158879007663	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
158879007664	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
158879007665	active site lid residues [active]
158879007666	substrate binding pocket [chemical binding]; other site
158879007667	catalytic residues [active]
158879007668	substrate-Mg2+ binding site; other site
158879007669	aspartate-rich region 1; other site
158879007670	aspartate-rich region 2; other site
158879007671	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
158879007672	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
158879007673	active site
158879007674	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
158879007675	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
158879007676	Surface antigen [General function prediction only]; Region: COG3942
158879007677	CHAP domain; Region: CHAP; pfam05257
158879007678	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
158879007679	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
158879007680	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
158879007681	catalytic triad [active]
158879007682	catalytic triad [active]
158879007683	oxyanion hole [active]
158879007684	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879007685	Coenzyme A binding pocket [chemical binding]; other site
158879007686	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
158879007687	N-acetyl-D-glucosamine binding site [chemical binding]; other site
158879007688	catalytic residue [active]
158879007689	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
158879007690	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
158879007691	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
158879007692	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
158879007693	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
158879007694	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
158879007695	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
158879007696	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
158879007697	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
158879007698	NmrA-like family; Region: NmrA; pfam05368
158879007699	NADP binding site [chemical binding]; other site
158879007700	active site
158879007701	regulatory binding site [polypeptide binding]; other site
158879007702	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367
158879007703	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
158879007704	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
158879007705	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
158879007706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
158879007707	NAD(P) binding site [chemical binding]; other site
158879007708	active site
158879007709	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
158879007710	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
158879007711	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
158879007712	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
158879007713	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
158879007714	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
158879007715	Nucleoside recognition; Region: Gate; pfam07670
158879007716	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
158879007717	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
158879007718	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495
158879007719	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
158879007720	Phosphotransferase enzyme family; Region: APH; pfam01636
158879007721	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
158879007722	active site
158879007723	ATP binding site [chemical binding]; other site
158879007724	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
158879007725	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
158879007726	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
158879007727	quinone interaction residues [chemical binding]; other site
158879007728	active site
158879007729	catalytic residues [active]
158879007730	FMN binding site [chemical binding]; other site
158879007731	substrate binding site [chemical binding]; other site
158879007732	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
158879007733	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
158879007734	dimer interface [polypeptide binding]; other site
158879007735	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
158879007736	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
158879007737	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
158879007738	Predicted acyl esterases [General function prediction only]; Region: COG2936
158879007739	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
158879007740	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
158879007741	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879007742	S-adenosylmethionine binding site [chemical binding]; other site
158879007743	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
158879007744	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879007745	S-adenosylmethionine binding site [chemical binding]; other site
158879007746	aminoglycoside resistance protein; Provisional; Region: PRK13746
158879007747	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
158879007748	active site
158879007749	NTP binding site [chemical binding]; other site
158879007750	metal binding triad [ion binding]; metal-binding site
158879007751	antibiotic binding site [chemical binding]; other site
158879007752	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
158879007753	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
158879007754	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
158879007755	Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195
158879007756	Int/Topo IB signature motif; other site
158879007757	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
158879007758	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
158879007759	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
158879007760	Int/Topo IB signature motif; other site
158879007761	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
158879007762	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
158879007763	tetramerization interface [polypeptide binding]; other site
158879007764	active site
158879007765	pantoate--beta-alanine ligase; Region: panC; TIGR00018
158879007766	Pantoate-beta-alanine ligase; Region: PanC; cd00560
158879007767	active site
158879007768	ATP-binding site [chemical binding]; other site
158879007769	pantoate-binding site; other site
158879007770	HXXH motif; other site
158879007771	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
158879007772	oligomerization interface [polypeptide binding]; other site
158879007773	active site
158879007774	metal binding site [ion binding]; metal-binding site
158879007775	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
158879007776	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
158879007777	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
158879007778	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
158879007779	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
158879007780	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
158879007781	tetramer (dimer of dimers) interface [polypeptide binding]; other site
158879007782	NAD binding site [chemical binding]; other site
158879007783	dimer interface [polypeptide binding]; other site
158879007784	substrate binding site [chemical binding]; other site
158879007785	amino acid transporter; Region: 2A0306; TIGR00909
158879007786	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
158879007787	4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
158879007788	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
158879007789	inhibitor-cofactor binding pocket; inhibition site
158879007790	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879007791	catalytic residue [active]
158879007792	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
158879007793	catalytic residue [active]
158879007794	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
158879007795	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
158879007796	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
158879007797	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
158879007798	acyl-activating enzyme (AAE) consensus motif; other site
158879007799	AMP binding site [chemical binding]; other site
158879007800	active site
158879007801	CoA binding site [chemical binding]; other site
158879007802	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
158879007803	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
158879007804	choline dehydrogenase; Validated; Region: PRK02106
158879007805	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
158879007806	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
158879007807	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
158879007808	tetramerization interface [polypeptide binding]; other site
158879007809	NAD(P) binding site [chemical binding]; other site
158879007810	catalytic residues [active]
158879007811	Predicted transcriptional regulators [Transcription]; Region: COG1510
158879007812	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
158879007813	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
158879007814	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
158879007815	FeS/SAM binding site; other site
158879007816	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
158879007817	Class III ribonucleotide reductase; Region: RNR_III; cd01675
158879007818	effector binding site; other site
158879007819	active site
158879007820	Zn binding site [ion binding]; other site
158879007821	glycine loop; other site
158879007822	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
158879007823	Citrate transporter; Region: CitMHS; pfam03600
158879007824	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
158879007825	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
158879007826	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
158879007827	Flavodoxin; Region: Flavodoxin_1; pfam00258
158879007828	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
158879007829	FAD binding pocket [chemical binding]; other site
158879007830	FAD binding motif [chemical binding]; other site
158879007831	catalytic residues [active]
158879007832	NAD binding pocket [chemical binding]; other site
158879007833	phosphate binding motif [ion binding]; other site
158879007834	beta-alpha-beta structure motif; other site
158879007835	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
158879007836	catalytic residues [active]
158879007837	dimer interface [polypeptide binding]; other site
158879007838	FtsX-like permease family; Region: FtsX; pfam02687
158879007839	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
158879007840	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
158879007841	Walker A/P-loop; other site
158879007842	ATP binding site [chemical binding]; other site
158879007843	Q-loop/lid; other site
158879007844	ABC transporter signature motif; other site
158879007845	Walker B; other site
158879007846	D-loop; other site
158879007847	H-loop/switch region; other site
158879007848	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
158879007849	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
158879007850	ATP binding site [chemical binding]; other site
158879007851	Mg2+ binding site [ion binding]; other site
158879007852	G-X-G motif; other site
158879007853	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
158879007854	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
158879007855	active site
158879007856	phosphorylation site [posttranslational modification]
158879007857	intermolecular recognition site; other site
158879007858	dimerization interface [polypeptide binding]; other site
158879007859	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
158879007860	DNA binding site [nucleotide binding]
158879007861	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
158879007862	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
158879007863	dimer interface [polypeptide binding]; other site
158879007864	active site
158879007865	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
158879007866	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
158879007867	MarR family; Region: MarR_2; pfam12802
158879007868	Predicted esterase [General function prediction only]; Region: COG0627
158879007869	S-formylglutathione hydrolase; Region: PLN02442
158879007870	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
158879007871	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
158879007872	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
158879007873	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
158879007874	ligand binding site [chemical binding]; other site
158879007875	flexible hinge region; other site
158879007876	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
158879007877	carbamate kinase; Reviewed; Region: PRK12686
158879007878	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
158879007879	putative substrate binding site [chemical binding]; other site
158879007880	nucleotide binding site [chemical binding]; other site
158879007881	nucleotide binding site [chemical binding]; other site
158879007882	homodimer interface [polypeptide binding]; other site
158879007883	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
158879007884	ornithine carbamoyltransferase; Validated; Region: PRK02102
158879007885	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
158879007886	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
158879007887	arginine deiminase; Provisional; Region: PRK01388
158879007888	Arginine repressor [Transcription]; Region: ArgR; COG1438
158879007889	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
158879007890	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
158879007891	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
158879007892	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
158879007893	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
158879007894	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
158879007895	active site
158879007896	Zn binding site [ion binding]; other site
158879007897	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
158879007898	HTH domain; Region: HTH_11; pfam08279
158879007899	PRD domain; Region: PRD; pfam00874
158879007900	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
158879007901	active site
158879007902	P-loop; other site
158879007903	phosphorylation site [posttranslational modification]
158879007904	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
158879007905	active site
158879007906	phosphorylation site [posttranslational modification]
158879007907	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
158879007908	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
158879007909	active site
158879007910	P-loop; other site
158879007911	phosphorylation site [posttranslational modification]
158879007912	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
158879007913	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
158879007914	active site
158879007915	phosphorylation site [posttranslational modification]
158879007916	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
158879007917	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
158879007918	Predicted membrane protein [Function unknown]; Region: COG1511
158879007919	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
158879007920	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
158879007921	N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581
158879007922	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
158879007923	CHAP domain; Region: CHAP; pfam05257
158879007924	Isochorismatase family; Region: Isochorismatase; pfam00857
158879007925	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
158879007926	catalytic triad [active]
158879007927	conserved cis-peptide bond; other site
158879007928	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
158879007929	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
158879007930	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
158879007931	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
158879007932	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
158879007933	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
158879007934	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
158879007935	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
158879007936	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
158879007937	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
158879007938	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
158879007939	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
158879007940	SecY translocase; Region: SecY; pfam00344
158879007941	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
158879007942	legume lectins; Region: lectin_L-type; cd01951
158879007943	homotetramer interaction site [polypeptide binding]; other site
158879007944	carbohydrate binding site [chemical binding]; other site
158879007945	metal binding site [ion binding]; metal-binding site
158879007946	Putative Ig domain; Region: He_PIG; pfam05345
158879007947	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
158879007948	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
158879007949	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
158879007950	methionine sulfoxide reductase A; Provisional; Region: PRK05528
158879007951	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
158879007952	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
158879007953	Coenzyme A binding pocket [chemical binding]; other site
158879007954	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
158879007955	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
158879007956	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
158879007957	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
158879007958	Chain length determinant protein; Region: Wzz; cl15801
158879007959	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
158879007960	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
158879007961	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
158879007962	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
158879007963	DXD motif; other site
158879007964	intracellular adhesion protein D; Region: PIA_icaD; TIGR03932
158879007965	intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933
158879007966	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
158879007967	Acyltransferase family; Region: Acyl_transf_3; pfam01757
158879007968	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
158879007969	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
158879007970	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
158879007971	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
158879007972	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
158879007973	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
158879007974	metal binding site [ion binding]; metal-binding site
158879007975	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
158879007976	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
158879007977	substrate binding site [chemical binding]; other site
158879007978	glutamase interaction surface [polypeptide binding]; other site
158879007979	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
158879007980	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
158879007981	catalytic residues [active]
158879007982	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
158879007983	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
158879007984	putative active site [active]
158879007985	oxyanion strand; other site
158879007986	catalytic triad [active]
158879007987	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
158879007988	putative active site pocket [active]
158879007989	4-fold oligomerization interface [polypeptide binding]; other site
158879007990	metal binding residues [ion binding]; metal-binding site
158879007991	3-fold/trimer interface [polypeptide binding]; other site
158879007992	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
158879007993	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
158879007994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
158879007995	homodimer interface [polypeptide binding]; other site
158879007996	catalytic residue [active]
158879007997	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
158879007998	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
158879007999	NAD binding site [chemical binding]; other site
158879008000	dimerization interface [polypeptide binding]; other site
158879008001	product binding site; other site
158879008002	substrate binding site [chemical binding]; other site
158879008003	zinc binding site [ion binding]; other site
158879008004	catalytic residues [active]
158879008005	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584
158879008006	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
158879008007	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294
158879008008	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
158879008009	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
158879008010	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
158879008011	putative active site [active]
158879008012	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
158879008013	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
158879008014	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
158879008015	Walker A/P-loop; other site
158879008016	ATP binding site [chemical binding]; other site
158879008017	ABC transporter; Region: ABC_tran; pfam00005
158879008018	Q-loop/lid; other site
158879008019	ABC transporter signature motif; other site
158879008020	Walker B; other site
158879008021	D-loop; other site
158879008022	H-loop/switch region; other site
158879008023	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
158879008024	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
158879008025	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
158879008026	Walker A/P-loop; other site
158879008027	ATP binding site [chemical binding]; other site
158879008028	Q-loop/lid; other site
158879008029	ABC transporter signature motif; other site
158879008030	Walker B; other site
158879008031	D-loop; other site
158879008032	H-loop/switch region; other site
158879008033	hypothetical protein; Provisional; Region: PRK13661
158879008034	Uncharacterized conserved protein [Function unknown]; Region: COG1912
158879008035	Uncharacterized conserved protein [Function unknown]; Region: COG2353
158879008036	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
158879008037	Strictosidine synthase; Region: Str_synth; pfam03088
158879008038	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
158879008039	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
158879008040	active site residue [active]
158879008041	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
158879008042	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
158879008043	putative substrate binding pocket [chemical binding]; other site
158879008044	AC domain interface; other site
158879008045	catalytic triad [active]
158879008046	AB domain interface; other site
158879008047	interchain disulfide; other site
158879008048	hypothetical protein; Validated; Region: PRK07668
158879008049	Predicted transcriptional regulators [Transcription]; Region: COG1695
158879008050	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
158879008051	DinB superfamily; Region: DinB_2; pfam12867
158879008052	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
158879008053	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
158879008054	transmembrane helices; other site
158879008055	Predicted permeases [General function prediction only]; Region: RarD; COG2962
158879008056	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
158879008057	hypothetical protein; Provisional; Region: PRK07758
158879008058	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
158879008059	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
158879008060	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
158879008061	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
158879008062	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
158879008063	Walker A/P-loop; other site
158879008064	ATP binding site [chemical binding]; other site
158879008065	Q-loop/lid; other site
158879008066	ABC transporter signature motif; other site
158879008067	Walker B; other site
158879008068	D-loop; other site
158879008069	H-loop/switch region; other site
158879008070	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
158879008071	FtsX-like permease family; Region: FtsX; pfam02687
158879008072	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
158879008073	DNA-binding site [nucleotide binding]; DNA binding site
158879008074	RNA-binding motif; other site
158879008075	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
158879008076	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
158879008077	non-specific DNA binding site [nucleotide binding]; other site
158879008078	salt bridge; other site
158879008079	sequence-specific DNA binding site [nucleotide binding]; other site
158879008080	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
158879008081	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
158879008082	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
158879008083	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
158879008084	ParB-like nuclease domain; Region: ParBc; pfam02195
158879008085	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
158879008086	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
158879008087	S-adenosylmethionine binding site [chemical binding]; other site
158879008088	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
158879008089	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
158879008090	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
158879008091	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
158879008092	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
158879008093	trmE is a tRNA modification GTPase; Region: trmE; cd04164
158879008094	G1 box; other site
158879008095	GTP/Mg2+ binding site [chemical binding]; other site
158879008096	Switch I region; other site
158879008097	G2 box; other site
158879008098	Switch II region; other site
158879008099	G3 box; other site
158879008100	G4 box; other site
158879008101	G5 box; other site
158879008102	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
158879008103	ribonuclease P; Reviewed; Region: rnpA; PRK00499
158879008104	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
158879008105	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
158879008106	Plasmid rolling circle replication initiator protein and truncated derivatives [DNA replication, recombination, and repair]; Region: COG5655
158879008107	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
158879008108	Cadmium resistance transporter; Region: Cad; pfam03596
158879008109	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
158879008110	putative DNA binding site [nucleotide binding]; other site
158879008111	putative Zn2+ binding site [ion binding]; other site
158879008112	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
158879008113	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
158879008114	NADP binding site [chemical binding]; other site
158879008115	dimer interface [polypeptide binding]; other site
158879008116	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
158879008117	MarR family; Region: MarR_2; pfam12802
158879008118	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
158879008119	beta-lactamase TEM; Provisional; Region: PRK15442
158879008120	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
158879008121	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
158879008122	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
158879008123	Predicted transcriptional regulator [Transcription]; Region: COG3682
158879008124	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
158879008125	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
158879008126	catalytic residues [active]
158879008127	catalytic nucleophile [active]
158879008128	Presynaptic Site I dimer interface [polypeptide binding]; other site
158879008129	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
158879008130	Synaptic Flat tetramer interface [polypeptide binding]; other site
158879008131	Synaptic Site I dimer interface [polypeptide binding]; other site
158879008132	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
158879008133	DNA-binding interface [nucleotide binding]; DNA binding site
158879008134	Helix-turn-helix domain; Region: HTH_28; pfam13518
158879008135	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
158879008136	Integrase core domain; Region: rve; pfam00665
158879008137	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
158879008138	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
158879008139	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
158879008140	Presynaptic Site I dimer interface [polypeptide binding]; other site
158879008141	catalytic residues [active]
158879008142	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
158879008143	Synaptic Flat tetramer interface [polypeptide binding]; other site
158879008144	Synaptic Site I dimer interface [polypeptide binding]; other site
158879008145	DNA binding site [nucleotide binding]
158879008146	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
158879008147	DNA-binding interface [nucleotide binding]; DNA binding site
158879008148	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
158879008149	dimerization interface [polypeptide binding]; other site
158879008150	putative DNA binding site [nucleotide binding]; other site
158879008151	putative Zn2+ binding site [ion binding]; other site
158879008152	arsenical pump membrane protein; Provisional; Region: PRK15445
158879008153	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
158879008154	transmembrane helices; other site
158879008155	Low molecular weight phosphatase family; Region: LMWPc; cd00115
158879008156	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
158879008157	active site
158879008158	bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653
158879008159	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
158879008160	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
158879008161	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
158879008162	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
158879008163	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
158879008164	Walker A/P-loop; other site
158879008165	ATP binding site [chemical binding]; other site
158879008166	Q-loop/lid; other site
158879008167	ABC transporter signature motif; other site
158879008168	Walker B; other site
158879008169	D-loop; other site
158879008170	H-loop/switch region; other site
158879008171	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
158879008172	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
158879008173	Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527
158879008174	Initiator Replication protein; Region: Rep_3; pfam01051
158879008175	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
158879008176	non-specific DNA binding site [nucleotide binding]; other site
158879008177	salt bridge; other site
158879008178	sequence-specific DNA binding site [nucleotide binding]; other site