-- dump date 20140620_074609 -- class Genbank::misc_feature -- table misc_feature_note -- id note 93061000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 93061000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 93061000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061000004 Walker A motif; other site 93061000005 ATP binding site [chemical binding]; other site 93061000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 93061000007 Walker B motif; other site 93061000008 arginine finger; other site 93061000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 93061000010 DnaA box-binding interface [nucleotide binding]; other site 93061000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 93061000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 93061000013 putative DNA binding surface [nucleotide binding]; other site 93061000014 dimer interface [polypeptide binding]; other site 93061000015 beta-clamp/clamp loader binding surface; other site 93061000016 beta-clamp/translesion DNA polymerase binding surface; other site 93061000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 93061000018 recF protein; Region: recf; TIGR00611 93061000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 93061000020 Walker A/P-loop; other site 93061000021 ATP binding site [chemical binding]; other site 93061000022 Q-loop/lid; other site 93061000023 ABC transporter signature motif; other site 93061000024 Walker B; other site 93061000025 D-loop; other site 93061000026 H-loop/switch region; other site 93061000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 93061000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061000029 ATP binding site [chemical binding]; other site 93061000030 Mg2+ binding site [ion binding]; other site 93061000031 G-X-G motif; other site 93061000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 93061000033 anchoring element; other site 93061000034 dimer interface [polypeptide binding]; other site 93061000035 ATP binding site [chemical binding]; other site 93061000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 93061000037 active site 93061000038 putative metal-binding site [ion binding]; other site 93061000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 93061000040 DNA gyrase subunit A; Validated; Region: PRK05560 93061000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 93061000042 CAP-like domain; other site 93061000043 active site 93061000044 primary dimer interface [polypeptide binding]; other site 93061000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93061000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93061000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93061000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93061000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93061000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93061000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 93061000052 putative substrate binding site [chemical binding]; other site 93061000053 putative ATP binding site [chemical binding]; other site 93061000054 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 93061000055 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 93061000056 active sites [active] 93061000057 tetramer interface [polypeptide binding]; other site 93061000058 seryl-tRNA synthetase; Provisional; Region: PRK05431 93061000059 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 93061000060 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 93061000061 dimer interface [polypeptide binding]; other site 93061000062 active site 93061000063 motif 1; other site 93061000064 motif 2; other site 93061000065 motif 3; other site 93061000066 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 93061000067 Predicted membrane protein [Function unknown]; Region: COG4392 93061000068 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 93061000069 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 93061000070 Predicted membrane protein [Function unknown]; Region: COG4241 93061000071 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 93061000072 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 93061000073 DHH family; Region: DHH; pfam01368 93061000074 DHHA1 domain; Region: DHHA1; pfam02272 93061000075 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 93061000076 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 93061000077 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 93061000078 replicative DNA helicase; Region: DnaB; TIGR00665 93061000079 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 93061000080 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 93061000081 Walker A motif; other site 93061000082 ATP binding site [chemical binding]; other site 93061000083 Walker B motif; other site 93061000084 DNA binding loops [nucleotide binding] 93061000085 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 93061000086 GDP-binding site [chemical binding]; other site 93061000087 ACT binding site; other site 93061000088 IMP binding site; other site 93061000089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 93061000090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061000091 active site 93061000092 phosphorylation site [posttranslational modification] 93061000093 intermolecular recognition site; other site 93061000094 dimerization interface [polypeptide binding]; other site 93061000095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93061000096 DNA binding site [nucleotide binding] 93061000097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 93061000098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 93061000099 dimerization interface [polypeptide binding]; other site 93061000100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 93061000101 putative active site [active] 93061000102 heme pocket [chemical binding]; other site 93061000103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 93061000104 dimer interface [polypeptide binding]; other site 93061000105 phosphorylation site [posttranslational modification] 93061000106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061000107 ATP binding site [chemical binding]; other site 93061000108 Mg2+ binding site [ion binding]; other site 93061000109 G-X-G motif; other site 93061000110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 93061000111 YycH protein; Region: YycH; pfam07435 93061000112 YycH protein; Region: YycI; cl02015 93061000113 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 93061000114 BDLF3; Provisional; Region: PHA03255 93061000115 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 93061000116 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 93061000117 putative active site [active] 93061000118 putative metal binding site [ion binding]; other site 93061000119 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 93061000120 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 93061000121 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 93061000122 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 93061000123 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 93061000124 phosphate binding site [ion binding]; other site 93061000125 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 93061000126 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 93061000127 putative homodimer interface [polypeptide binding]; other site 93061000128 putative homotetramer interface [polypeptide binding]; other site 93061000129 putative metal binding site [ion binding]; other site 93061000130 putative homodimer-homodimer interface [polypeptide binding]; other site 93061000131 putative allosteric switch controlling residues; other site 93061000132 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 93061000133 active site residue [active] 93061000134 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 93061000135 CPxP motif; other site 93061000136 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 93061000137 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 93061000138 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 93061000139 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 93061000140 active site residue [active] 93061000141 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 93061000142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 93061000143 Universal stress protein UspA and related nucleotide-binding proteins [Signal transduction mechanisms]; Region: UspA; COG0589 93061000144 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 93061000145 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 93061000146 FMN binding site [chemical binding]; other site 93061000147 active site 93061000148 catalytic residues [active] 93061000149 substrate binding site [chemical binding]; other site 93061000150 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 93061000151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061000152 H+ Antiporter protein; Region: 2A0121; TIGR00900 93061000153 putative substrate translocation pore; other site 93061000154 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 93061000155 Transcriptional regulator [Transcription]; Region: LysR; COG0583 93061000156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 93061000157 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 93061000158 dimerization interface [polypeptide binding]; other site 93061000159 Transcriptional regulator [Transcription]; Region: LysR; COG0583 93061000160 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 93061000161 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 93061000162 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 93061000163 Part of AAA domain; Region: AAA_19; pfam13245 93061000164 AAA domain; Region: AAA_12; pfam13087 93061000165 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 93061000166 active site 93061000167 catalytic site [active] 93061000168 putative metal binding site [ion binding]; other site 93061000169 Protein of unknown function, DUF576; Region: DUF576; pfam04507 93061000170 Protein of unknown function, DUF576; Region: DUF576; pfam04507 93061000171 Protein of unknown function, DUF576; Region: DUF576; pfam04507 93061000172 Protein of unknown function, DUF576; Region: DUF576; pfam04507 93061000173 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 93061000174 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 93061000175 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 93061000176 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 93061000177 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 93061000178 metal binding site [ion binding]; metal-binding site 93061000179 dimer interface [polypeptide binding]; other site 93061000180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061000181 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061000182 putative substrate translocation pore; other site 93061000183 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 93061000184 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 93061000185 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 93061000186 PhoU domain; Region: PhoU; pfam01895 93061000187 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 93061000188 myosin-cross-reactive antigen; Provisional; Region: PRK13977 93061000189 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 93061000190 EamA-like transporter family; Region: EamA; pfam00892 93061000191 EamA-like transporter family; Region: EamA; pfam00892 93061000192 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 93061000193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 93061000194 DNA-binding site [nucleotide binding]; DNA binding site 93061000195 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93061000196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061000197 homodimer interface [polypeptide binding]; other site 93061000198 catalytic residue [active] 93061000199 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 93061000200 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 93061000201 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 93061000202 B domain; Region: B; pfam02216 93061000203 B domain; Region: B; pfam02216 93061000204 B domain; Region: B; pfam02216 93061000205 B domain; Region: B; pfam02216 93061000206 B domain; Region: B; pfam02216 93061000207 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93061000208 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 93061000209 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061000210 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 93061000211 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061000212 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 93061000213 ABC-ATPase subunit interface; other site 93061000214 dimer interface [polypeptide binding]; other site 93061000215 putative PBP binding regions; other site 93061000216 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 93061000217 ABC-ATPase subunit interface; other site 93061000218 dimer interface [polypeptide binding]; other site 93061000219 putative PBP binding regions; other site 93061000220 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 93061000221 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 93061000222 siderophore binding site; other site 93061000223 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 93061000224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061000225 catalytic residue [active] 93061000226 dimer interface [polypeptide binding]; other site 93061000227 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 93061000228 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 93061000229 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 93061000230 IucA / IucC family; Region: IucA_IucC; pfam04183 93061000231 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 93061000232 drug efflux system protein MdtG; Provisional; Region: PRK09874 93061000233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061000234 putative substrate translocation pore; other site 93061000235 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 93061000236 IucA / IucC family; Region: IucA_IucC; pfam04183 93061000237 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 93061000238 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 93061000239 IucA / IucC family; Region: IucA_IucC; pfam04183 93061000240 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 93061000241 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 93061000242 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 93061000243 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 93061000244 dimer interface [polypeptide binding]; other site 93061000245 active site 93061000246 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 93061000247 catalytic residues [active] 93061000248 substrate binding site [chemical binding]; other site 93061000249 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 93061000250 ParB-like nuclease domain; Region: ParBc; pfam02195 93061000251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061000252 acetoin reductase; Validated; Region: PRK08643 93061000253 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 93061000254 NAD binding site [chemical binding]; other site 93061000255 homotetramer interface [polypeptide binding]; other site 93061000256 homodimer interface [polypeptide binding]; other site 93061000257 active site 93061000258 substrate binding site [chemical binding]; other site 93061000259 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93061000260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93061000261 NAD(P) binding site [chemical binding]; other site 93061000262 active site 93061000263 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 93061000264 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 93061000265 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 93061000266 putative ADP-binding pocket [chemical binding]; other site 93061000267 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 93061000268 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 93061000269 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 93061000270 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 93061000271 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 93061000272 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 93061000273 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 93061000274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 93061000275 DNA-binding site [nucleotide binding]; DNA binding site 93061000276 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 93061000277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061000278 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061000279 putative substrate translocation pore; other site 93061000280 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 93061000281 intersubunit interface [polypeptide binding]; other site 93061000282 active site 93061000283 catalytic residue [active] 93061000284 phosphopentomutase; Region: deoB; TIGR01696 93061000285 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 93061000286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061000287 dimer interface [polypeptide binding]; other site 93061000288 conserved gate region; other site 93061000289 putative PBP binding loops; other site 93061000290 ABC-ATPase subunit interface; other site 93061000291 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 93061000292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061000293 dimer interface [polypeptide binding]; other site 93061000294 conserved gate region; other site 93061000295 putative PBP binding loops; other site 93061000296 ABC-ATPase subunit interface; other site 93061000297 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 93061000298 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 93061000299 Walker A/P-loop; other site 93061000300 ATP binding site [chemical binding]; other site 93061000301 Q-loop/lid; other site 93061000302 ABC transporter signature motif; other site 93061000303 Walker B; other site 93061000304 D-loop; other site 93061000305 H-loop/switch region; other site 93061000306 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 93061000307 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 93061000308 substrate binding pocket [chemical binding]; other site 93061000309 membrane-bound complex binding site; other site 93061000310 hinge residues; other site 93061000311 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 93061000312 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 93061000313 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 93061000314 active site 93061000315 metal binding site [ion binding]; metal-binding site 93061000316 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 93061000317 Replication initiation factor; Region: Rep_trans; pfam02486 93061000318 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 93061000319 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 93061000320 putative catalytic cysteine [active] 93061000321 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 93061000322 putative active site [active] 93061000323 metal binding site [ion binding]; metal-binding site 93061000324 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 93061000325 Chain length determinant protein; Region: Wzz; pfam02706 93061000326 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 93061000327 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 93061000328 AAA domain; Region: AAA_31; pfam13614 93061000329 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 93061000330 PHP domain; Region: PHP; pfam02811 93061000331 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 93061000332 CoA binding domain; Region: CoA_binding; cl17356 93061000333 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 93061000334 NAD(P) binding site [chemical binding]; other site 93061000335 homodimer interface [polypeptide binding]; other site 93061000336 substrate binding site [chemical binding]; other site 93061000337 active site 93061000338 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 93061000339 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 93061000340 NAD(P) binding site [chemical binding]; other site 93061000341 homodimer interface [polypeptide binding]; other site 93061000342 substrate binding site [chemical binding]; other site 93061000343 active site 93061000344 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 93061000345 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 93061000346 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 93061000347 putative NAD(P) binding site [chemical binding]; other site 93061000348 active site 93061000349 putative substrate binding site [chemical binding]; other site 93061000350 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 93061000351 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 93061000352 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 93061000353 active site 93061000354 homodimer interface [polypeptide binding]; other site 93061000355 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 93061000356 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 93061000357 trimer interface [polypeptide binding]; other site 93061000358 active site 93061000359 substrate binding site [chemical binding]; other site 93061000360 CoA binding site [chemical binding]; other site 93061000361 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 93061000362 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 93061000363 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 93061000364 O-Antigen ligase; Region: Wzy_C; pfam04932 93061000365 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 93061000366 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 93061000367 Bacterial sugar transferase; Region: Bac_transf; pfam02397 93061000368 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 93061000369 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 93061000370 putative NAD(P) binding site [chemical binding]; other site 93061000371 active site 93061000372 putative substrate binding site [chemical binding]; other site 93061000373 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 93061000374 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 93061000375 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 93061000376 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 93061000377 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 93061000378 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 93061000379 active site 93061000380 homodimer interface [polypeptide binding]; other site 93061000381 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 93061000382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 93061000383 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 93061000384 NAD(P) binding site [chemical binding]; other site 93061000385 catalytic residues [active] 93061000386 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 93061000387 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 93061000388 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 93061000389 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 93061000390 Walker A/P-loop; other site 93061000391 ATP binding site [chemical binding]; other site 93061000392 Q-loop/lid; other site 93061000393 ABC transporter signature motif; other site 93061000394 Walker B; other site 93061000395 D-loop; other site 93061000396 H-loop/switch region; other site 93061000397 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 93061000398 NMT1-like family; Region: NMT1_2; cl17432 93061000399 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 93061000400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061000401 dimer interface [polypeptide binding]; other site 93061000402 conserved gate region; other site 93061000403 putative PBP binding loops; other site 93061000404 ABC-ATPase subunit interface; other site 93061000405 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 93061000406 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 93061000407 active site 93061000408 Uncharacterized conserved protein [Function unknown]; Region: COG5609 93061000409 formate dehydrogenase; Provisional; Region: PRK07574 93061000410 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 93061000411 dimerization interface [polypeptide binding]; other site 93061000412 ligand binding site [chemical binding]; other site 93061000413 NAD binding site [chemical binding]; other site 93061000414 catalytic site [active] 93061000415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061000416 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061000417 putative substrate translocation pore; other site 93061000418 Condensation domain; Region: Condensation; cl19241 93061000419 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 93061000420 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 93061000421 acyl-activating enzyme (AAE) consensus motif; other site 93061000422 AMP binding site [chemical binding]; other site 93061000423 active site 93061000424 CoA binding site [chemical binding]; other site 93061000425 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 93061000426 Condensation domain; Region: Condensation; pfam00668 93061000427 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 93061000428 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 93061000429 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 93061000430 acyl-activating enzyme (AAE) consensus motif; other site 93061000431 AMP binding site [chemical binding]; other site 93061000432 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 93061000433 thioester reductase domain; Region: Thioester-redct; TIGR01746 93061000434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93061000435 NAD(P) binding site [chemical binding]; other site 93061000436 active site 93061000437 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 93061000438 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 93061000439 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 93061000440 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 93061000441 nucleotide binding site [chemical binding]; other site 93061000442 N-acetyl-L-glutamate binding site [chemical binding]; other site 93061000443 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 93061000444 heterotetramer interface [polypeptide binding]; other site 93061000445 active site pocket [active] 93061000446 cleavage site 93061000447 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 93061000448 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 93061000449 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 93061000450 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 93061000451 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 93061000452 inhibitor-cofactor binding pocket; inhibition site 93061000453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061000454 catalytic residue [active] 93061000455 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 93061000456 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 93061000457 catalytic triad [active] 93061000458 conserved cis-peptide bond; other site 93061000459 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 93061000460 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 93061000461 dimer interface [polypeptide binding]; other site 93061000462 PYR/PP interface [polypeptide binding]; other site 93061000463 TPP binding site [chemical binding]; other site 93061000464 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 93061000465 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 93061000466 TPP-binding site [chemical binding]; other site 93061000467 dimer interface [polypeptide binding]; other site 93061000468 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 93061000469 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 93061000470 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 93061000471 active site turn [active] 93061000472 phosphorylation site [posttranslational modification] 93061000473 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 93061000474 HPr interaction site; other site 93061000475 glycerol kinase (GK) interaction site [polypeptide binding]; other site 93061000476 active site 93061000477 phosphorylation site [posttranslational modification] 93061000478 Uncharacterized conserved protein [Function unknown]; Region: COG3589 93061000479 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 93061000480 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 93061000481 putative active site [active] 93061000482 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 93061000483 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 93061000484 active site turn [active] 93061000485 phosphorylation site [posttranslational modification] 93061000486 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 93061000487 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 93061000488 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 93061000489 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 93061000490 putative active site [active] 93061000491 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 93061000492 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 93061000493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93061000494 ATP binding site [chemical binding]; other site 93061000495 putative Mg++ binding site [ion binding]; other site 93061000496 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 93061000497 RES domain; Region: RES; pfam08808 93061000498 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 93061000499 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 93061000500 Walker A/P-loop; other site 93061000501 ATP binding site [chemical binding]; other site 93061000502 Q-loop/lid; other site 93061000503 ABC transporter signature motif; other site 93061000504 Walker B; other site 93061000505 D-loop; other site 93061000506 H-loop/switch region; other site 93061000507 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 93061000508 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 93061000509 Walker A/P-loop; other site 93061000510 ATP binding site [chemical binding]; other site 93061000511 Q-loop/lid; other site 93061000512 ABC transporter signature motif; other site 93061000513 Walker B; other site 93061000514 D-loop; other site 93061000515 H-loop/switch region; other site 93061000516 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 93061000517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061000518 dimer interface [polypeptide binding]; other site 93061000519 conserved gate region; other site 93061000520 putative PBP binding loops; other site 93061000521 ABC-ATPase subunit interface; other site 93061000522 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 93061000523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061000524 dimer interface [polypeptide binding]; other site 93061000525 conserved gate region; other site 93061000526 putative PBP binding loops; other site 93061000527 ABC-ATPase subunit interface; other site 93061000528 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 93061000529 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 93061000530 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 93061000531 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 93061000532 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742 93061000533 azoreductase; Reviewed; Region: PRK00170 93061000534 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 93061000535 Peptidase family M23; Region: Peptidase_M23; pfam01551 93061000536 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 93061000537 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 93061000538 Walker A/P-loop; other site 93061000539 ATP binding site [chemical binding]; other site 93061000540 Q-loop/lid; other site 93061000541 ABC transporter signature motif; other site 93061000542 Walker B; other site 93061000543 D-loop; other site 93061000544 H-loop/switch region; other site 93061000545 TOBE domain; Region: TOBE; pfam03459 93061000546 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 93061000547 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 93061000548 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 93061000549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061000550 dimer interface [polypeptide binding]; other site 93061000551 conserved gate region; other site 93061000552 putative PBP binding loops; other site 93061000553 ABC-ATPase subunit interface; other site 93061000554 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 93061000555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061000556 dimer interface [polypeptide binding]; other site 93061000557 conserved gate region; other site 93061000558 putative PBP binding loops; other site 93061000559 ABC-ATPase subunit interface; other site 93061000560 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 93061000561 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 93061000562 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 93061000563 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 93061000564 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 93061000565 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 93061000566 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 93061000567 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 93061000568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 93061000569 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 93061000570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061000571 putative substrate translocation pore; other site 93061000572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061000573 active site 93061000574 phosphorylation site [posttranslational modification] 93061000575 intermolecular recognition site; other site 93061000576 dimerization interface [polypeptide binding]; other site 93061000577 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 93061000578 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 93061000579 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 93061000580 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 93061000581 Histidine kinase; Region: His_kinase; pfam06580 93061000582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061000583 ATP binding site [chemical binding]; other site 93061000584 Mg2+ binding site [ion binding]; other site 93061000585 G-X-G motif; other site 93061000586 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 93061000587 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 93061000588 Pyruvate formate lyase 1; Region: PFL1; cd01678 93061000589 coenzyme A binding site [chemical binding]; other site 93061000590 active site 93061000591 catalytic residues [active] 93061000592 glycine loop; other site 93061000593 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 93061000594 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93061000595 FeS/SAM binding site; other site 93061000596 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 93061000597 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 93061000598 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 93061000599 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 93061000600 putative active site [active] 93061000601 catalytic site [active] 93061000602 putative metal binding site [ion binding]; other site 93061000603 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 93061000604 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 93061000605 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 93061000606 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 93061000607 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 93061000608 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 93061000609 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 93061000610 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 93061000611 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 93061000612 dimer interface [polypeptide binding]; other site 93061000613 active site 93061000614 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 93061000615 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 93061000616 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 93061000617 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 93061000618 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 93061000619 substrate binding site [chemical binding]; other site 93061000620 oxyanion hole (OAH) forming residues; other site 93061000621 trimer interface [polypeptide binding]; other site 93061000622 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 93061000623 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 93061000624 active site 93061000625 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 93061000626 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 93061000627 acyl-activating enzyme (AAE) consensus motif; other site 93061000628 AMP binding site [chemical binding]; other site 93061000629 active site 93061000630 CoA binding site [chemical binding]; other site 93061000631 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 93061000632 Coenzyme A transferase; Region: CoA_trans; smart00882 93061000633 Coenzyme A transferase; Region: CoA_trans; cl17247 93061000634 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 93061000635 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 93061000636 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 93061000637 Uncharacterized conserved protein [Function unknown]; Region: COG3189 93061000638 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 93061000639 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 93061000640 heme-binding site [chemical binding]; other site 93061000641 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 93061000642 FAD binding pocket [chemical binding]; other site 93061000643 FAD binding motif [chemical binding]; other site 93061000644 phosphate binding motif [ion binding]; other site 93061000645 beta-alpha-beta structure motif; other site 93061000646 NAD binding pocket [chemical binding]; other site 93061000647 Heme binding pocket [chemical binding]; other site 93061000648 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 93061000649 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 93061000650 dimer interface [polypeptide binding]; other site 93061000651 tetramer (dimer of dimers) interface [polypeptide binding]; other site 93061000652 NAD binding site [chemical binding]; other site 93061000653 substrate binding site [chemical binding]; other site 93061000654 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 93061000655 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 93061000656 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 93061000657 active site turn [active] 93061000658 phosphorylation site [posttranslational modification] 93061000659 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 93061000660 active site 93061000661 tetramer interface [polypeptide binding]; other site 93061000662 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 93061000663 Mga helix-turn-helix domain; Region: Mga; pfam05043 93061000664 PRD domain; Region: PRD; pfam00874 93061000665 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 93061000666 active site 93061000667 P-loop; other site 93061000668 phosphorylation site [posttranslational modification] 93061000669 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 93061000670 active site 93061000671 phosphorylation site [posttranslational modification] 93061000672 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 93061000673 active site 93061000674 phosphorylation site [posttranslational modification] 93061000675 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 93061000676 active site 93061000677 P-loop; other site 93061000678 phosphorylation site [posttranslational modification] 93061000679 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 93061000680 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 93061000681 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 93061000682 putative NAD(P) binding site [chemical binding]; other site 93061000683 catalytic Zn binding site [ion binding]; other site 93061000684 structural Zn binding site [ion binding]; other site 93061000685 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 93061000686 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 93061000687 putative NAD(P) binding site [chemical binding]; other site 93061000688 catalytic Zn binding site [ion binding]; other site 93061000689 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 93061000690 substrate binding site; other site 93061000691 dimer interface; other site 93061000692 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 93061000693 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 93061000694 NAD(P) binding site [chemical binding]; other site 93061000695 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 93061000696 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 93061000697 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 93061000698 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 93061000699 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 93061000700 substrate binding site; other site 93061000701 dimer interface; other site 93061000702 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 93061000703 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 93061000704 putative NAD(P) binding site [chemical binding]; other site 93061000705 putative catalytic Zn binding site [ion binding]; other site 93061000706 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 93061000707 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 93061000708 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 93061000709 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 93061000710 active site 93061000711 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 93061000712 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 93061000713 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 93061000714 Fe binding site [ion binding]; other site 93061000715 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 93061000716 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 93061000717 GAF domain; Region: GAF; pfam01590 93061000718 Histidine kinase; Region: His_kinase; pfam06580 93061000719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061000720 ATP binding site [chemical binding]; other site 93061000721 Mg2+ binding site [ion binding]; other site 93061000722 G-X-G motif; other site 93061000723 two-component response regulator; Provisional; Region: PRK14084 93061000724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061000725 active site 93061000726 phosphorylation site [posttranslational modification] 93061000727 intermolecular recognition site; other site 93061000728 dimerization interface [polypeptide binding]; other site 93061000729 LytTr DNA-binding domain; Region: LytTR; pfam04397 93061000730 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 93061000731 antiholin-like protein LrgB; Provisional; Region: PRK04288 93061000732 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 93061000733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 93061000734 DNA-binding site [nucleotide binding]; DNA binding site 93061000735 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 93061000736 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 93061000737 active site turn [active] 93061000738 phosphorylation site [posttranslational modification] 93061000739 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 93061000740 HPr interaction site; other site 93061000741 glycerol kinase (GK) interaction site [polypeptide binding]; other site 93061000742 active site 93061000743 phosphorylation site [posttranslational modification] 93061000744 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 93061000745 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 93061000746 Methyltransferase domain; Region: Methyltransf_31; pfam13847 93061000747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061000748 S-adenosylmethionine binding site [chemical binding]; other site 93061000749 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 93061000750 substrate binding site [chemical binding]; other site 93061000751 dimer interface [polypeptide binding]; other site 93061000752 ATP binding site [chemical binding]; other site 93061000753 D-ribose pyranase; Provisional; Region: PRK11797 93061000754 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 93061000755 Sugar transport protein; Region: Sugar_transport; pfam06800 93061000756 Transcriptional regulators [Transcription]; Region: PurR; COG1609 93061000757 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 93061000758 DNA binding site [nucleotide binding] 93061000759 domain linker motif; other site 93061000760 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 93061000761 dimerization interface [polypeptide binding]; other site 93061000762 ligand binding site [chemical binding]; other site 93061000763 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061000764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061000765 putative substrate translocation pore; other site 93061000766 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 93061000767 active site 93061000768 Surface antigen [General function prediction only]; Region: COG3942 93061000769 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 93061000770 Peptidase family M23; Region: Peptidase_M23; pfam01551 93061000771 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 93061000772 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 93061000773 Walker A/P-loop; other site 93061000774 ATP binding site [chemical binding]; other site 93061000775 Q-loop/lid; other site 93061000776 ABC transporter signature motif; other site 93061000777 Walker B; other site 93061000778 D-loop; other site 93061000779 H-loop/switch region; other site 93061000780 Surface antigen [General function prediction only]; Region: COG3942 93061000781 CHAP domain; Region: CHAP; pfam05257 93061000782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 93061000783 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 93061000784 Predicted membrane protein [Function unknown]; Region: COG1511 93061000785 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 93061000786 heterodimer interface [polypeptide binding]; other site 93061000787 ABC-2 type transporter; Region: ABC2_membrane; cl17235 93061000788 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 93061000789 Uncharacterized small protein [Function unknown]; Region: COG5417 93061000790 Predicted membrane protein [Function unknown]; Region: COG4499 93061000791 TolA protein; Region: tolA_full; TIGR02794 93061000792 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 93061000793 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 93061000794 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 93061000795 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 93061000796 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 93061000797 Uncharacterized conserved protein [Function unknown]; Region: COG5444 93061000798 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 93061000799 Protein of unknown function, DUF600; Region: DUF600; cl04640 93061000800 conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741 93061000801 Protein of unknown function, DUF600; Region: DUF600; cl04640 93061000802 Protein of unknown function, DUF600; Region: DUF600; pfam04634 93061000803 Protein of unknown function, DUF600; Region: DUF600; cl04640 93061000804 conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741 93061000805 Domain of unknown function with cystatin-like fold (DUF4467); Region: DUF4467; pfam14729 93061000806 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 93061000807 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 93061000808 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 93061000809 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 93061000810 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 93061000811 FtsX-like permease family; Region: FtsX; pfam02687 93061000812 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 93061000813 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 93061000814 Walker A/P-loop; other site 93061000815 ATP binding site [chemical binding]; other site 93061000816 Q-loop/lid; other site 93061000817 ABC transporter signature motif; other site 93061000818 Walker B; other site 93061000819 D-loop; other site 93061000820 H-loop/switch region; other site 93061000821 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 93061000822 putative kinase; Provisional; Region: PRK09954 93061000823 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93061000824 non-specific DNA binding site [nucleotide binding]; other site 93061000825 salt bridge; other site 93061000826 sequence-specific DNA binding site [nucleotide binding]; other site 93061000827 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 93061000828 substrate binding site [chemical binding]; other site 93061000829 ATP binding site [chemical binding]; other site 93061000830 Uncharacterized enzyme involved in pigment biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IndA; COG2313 93061000831 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 93061000832 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 93061000833 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 93061000834 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 93061000835 Na binding site [ion binding]; other site 93061000836 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 93061000837 inhibitor site; inhibition site 93061000838 active site 93061000839 dimer interface [polypeptide binding]; other site 93061000840 catalytic residue [active] 93061000841 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 93061000842 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 93061000843 nucleotide binding site [chemical binding]; other site 93061000844 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 93061000845 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 93061000846 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 93061000847 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 93061000848 putative active site [active] 93061000849 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 93061000850 putative active site cavity [active] 93061000851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 93061000852 Nucleoside recognition; Region: Gate; pfam07670 93061000853 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 93061000854 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 93061000855 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 93061000856 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 93061000857 putative active site [active] 93061000858 putative FMN binding site [chemical binding]; other site 93061000859 putative substrate binding site [chemical binding]; other site 93061000860 putative catalytic residue [active] 93061000861 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 93061000862 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 93061000863 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 93061000864 lipoyl attachment site [posttranslational modification]; other site 93061000865 Replication protein C N-terminal domain; Region: RP-C; pfam03428 93061000866 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 93061000867 putative ADP-ribose binding site [chemical binding]; other site 93061000868 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 93061000869 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 93061000870 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 93061000871 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 93061000872 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93061000873 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 93061000874 NADP binding site [chemical binding]; other site 93061000875 putative substrate binding site [chemical binding]; other site 93061000876 active site 93061000877 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 93061000878 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 93061000879 active site 93061000880 P-loop; other site 93061000881 phosphorylation site [posttranslational modification] 93061000882 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 93061000883 active site 93061000884 phosphorylation site [posttranslational modification] 93061000885 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 93061000886 HTH domain; Region: HTH_11; pfam08279 93061000887 Mga helix-turn-helix domain; Region: Mga; pfam05043 93061000888 HTH domain; Region: HTH_11; pfam08279 93061000889 PRD domain; Region: PRD; pfam00874 93061000890 PRD domain; Region: PRD; pfam00874 93061000891 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 93061000892 active site 93061000893 P-loop; other site 93061000894 phosphorylation site [posttranslational modification] 93061000895 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 93061000896 active site 93061000897 phosphorylation site [posttranslational modification] 93061000898 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061000899 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 93061000900 putative DNA binding site [nucleotide binding]; other site 93061000901 putative Zn2+ binding site [ion binding]; other site 93061000902 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 93061000903 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 93061000904 MepB protein; Region: MepB; cl01985 93061000905 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 93061000906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061000907 putative substrate translocation pore; other site 93061000908 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 93061000909 Zn binding site [ion binding]; other site 93061000910 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 93061000911 Zn binding site [ion binding]; other site 93061000912 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 93061000913 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 93061000914 Predicted flavoprotein [General function prediction only]; Region: COG0431 93061000915 Predicted membrane protein [Function unknown]; Region: COG2855 93061000916 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 93061000917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 93061000918 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 93061000919 Imelysin; Region: Peptidase_M75; pfam09375 93061000920 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 93061000921 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 93061000922 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 93061000923 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 93061000924 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 93061000925 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93061000926 non-specific DNA binding site [nucleotide binding]; other site 93061000927 salt bridge; other site 93061000928 sequence-specific DNA binding site [nucleotide binding]; other site 93061000929 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 93061000930 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 93061000931 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 93061000932 Walker A/P-loop; other site 93061000933 ATP binding site [chemical binding]; other site 93061000934 Q-loop/lid; other site 93061000935 ABC transporter signature motif; other site 93061000936 Walker B; other site 93061000937 D-loop; other site 93061000938 H-loop/switch region; other site 93061000939 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 93061000940 Predicted membrane protein [Function unknown]; Region: COG4292 93061000941 putative acyltransferase; Provisional; Region: PRK05790 93061000942 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 93061000943 dimer interface [polypeptide binding]; other site 93061000944 active site 93061000945 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 93061000946 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 93061000947 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 93061000948 THF binding site; other site 93061000949 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 93061000950 substrate binding site [chemical binding]; other site 93061000951 THF binding site; other site 93061000952 zinc-binding site [ion binding]; other site 93061000953 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 93061000954 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 93061000955 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 93061000956 FAD binding site [chemical binding]; other site 93061000957 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 93061000958 homodimer interface [polypeptide binding]; other site 93061000959 substrate-cofactor binding pocket; other site 93061000960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061000961 catalytic residue [active] 93061000962 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 93061000963 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93061000964 catalytic residue [active] 93061000965 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 93061000966 ParB-like nuclease domain; Region: ParB; smart00470 93061000967 KorB domain; Region: KorB; pfam08535 93061000968 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 93061000969 Mechanosensitive ion channel; Region: MS_channel; pfam00924 93061000970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 93061000971 GTP-binding protein YchF; Reviewed; Region: PRK09601 93061000972 YchF GTPase; Region: YchF; cd01900 93061000973 G1 box; other site 93061000974 GTP/Mg2+ binding site [chemical binding]; other site 93061000975 Switch I region; other site 93061000976 G2 box; other site 93061000977 Switch II region; other site 93061000978 G3 box; other site 93061000979 G4 box; other site 93061000980 G5 box; other site 93061000981 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 93061000982 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 93061000983 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 93061000984 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 93061000985 dimer interface [polypeptide binding]; other site 93061000986 ssDNA binding site [nucleotide binding]; other site 93061000987 tetramer (dimer of dimers) interface [polypeptide binding]; other site 93061000988 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 93061000989 Abi-like protein; Region: Abi_2; pfam07751 93061000990 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 93061000991 DNA binding site [nucleotide binding] 93061000992 active site 93061000993 Int/Topo IB signature motif; other site 93061000994 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 93061000995 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061000996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 93061000997 Predicted membrane protein [Function unknown]; Region: COG3212 93061000998 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 93061000999 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93061001000 non-specific DNA binding site [nucleotide binding]; other site 93061001001 salt bridge; other site 93061001002 sequence-specific DNA binding site [nucleotide binding]; other site 93061001003 Predicted membrane protein [Function unknown]; Region: COG2261 93061001004 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 93061001005 catalytic core [active] 93061001006 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 93061001007 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 93061001008 catalytic residue [active] 93061001009 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 93061001010 catalytic residues [active] 93061001011 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 93061001012 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93061001013 peroxiredoxin; Region: AhpC; TIGR03137 93061001014 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 93061001015 dimer interface [polypeptide binding]; other site 93061001016 decamer (pentamer of dimers) interface [polypeptide binding]; other site 93061001017 catalytic triad [active] 93061001018 peroxidatic and resolving cysteines [active] 93061001019 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 93061001020 dimer interface [polypeptide binding]; other site 93061001021 FMN binding site [chemical binding]; other site 93061001022 NADPH bind site [chemical binding]; other site 93061001023 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 93061001024 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 93061001025 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93061001026 active site 93061001027 Sulfate transporter family; Region: Sulfate_transp; cl19250 93061001028 xanthine permease; Region: pbuX; TIGR03173 93061001029 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 93061001030 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 93061001031 active site 93061001032 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 93061001033 GMP synthase; Reviewed; Region: guaA; PRK00074 93061001034 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 93061001035 AMP/PPi binding site [chemical binding]; other site 93061001036 candidate oxyanion hole; other site 93061001037 catalytic triad [active] 93061001038 potential glutamine specificity residues [chemical binding]; other site 93061001039 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 93061001040 ATP Binding subdomain [chemical binding]; other site 93061001041 Ligand Binding sites [chemical binding]; other site 93061001042 Dimerization subdomain; other site 93061001043 PemK-like protein; Region: PemK; pfam02452 93061001044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 93061001045 Transposase; Region: HTH_Tnp_1; cl17663 93061001046 Predicted membrane protein [Function unknown]; Region: COG3759 93061001047 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 93061001048 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 93061001049 NADP binding site [chemical binding]; other site 93061001050 superantigen-like protein; Reviewed; Region: PRK13037 93061001051 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 93061001052 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061001053 superantigen-like protein; Reviewed; Region: PRK13041 93061001054 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 93061001055 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061001056 superantigen-like protein; Reviewed; Region: PRK13335 93061001057 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 93061001058 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061001059 superantigen-like protein; Reviewed; Region: PRK13042 93061001060 Mucin-like glycoprotein; Region: Mucin; pfam01456 93061001061 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 93061001062 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061001063 superantigen-like protein 5; Reviewed; Region: PRK13035 93061001064 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 93061001065 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061001066 superantigen-like protein; Reviewed; Region: PRK13040 93061001067 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 93061001068 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061001069 superantigen-like protein 7; Reviewed; Region: PRK13346 93061001070 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 93061001071 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061001072 superantigen-like protein; Reviewed; Region: PRK13039 93061001073 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 93061001074 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061001075 superantigen-like protein; Reviewed; Region: PRK13345 93061001076 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 93061001077 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061001078 superantigen-like protein; Reviewed; Region: PRK13038 93061001079 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 93061001080 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061001081 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 93061001082 HsdM N-terminal domain; Region: HsdM_N; pfam12161 93061001083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061001084 S-adenosylmethionine binding site [chemical binding]; other site 93061001085 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 93061001086 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 93061001087 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 93061001088 superantigen-like protein; Reviewed; Region: PRK13036 93061001089 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 93061001090 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061001091 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 93061001092 Protein of unknown function, DUF576; Region: DUF576; pfam04507 93061001093 Protein of unknown function, DUF576; Region: DUF576; pfam04507 93061001094 Protein of unknown function, DUF576; Region: DUF576; pfam04507 93061001095 Domain of unknown function (DUF3498); Region: DUF3498; pfam12004 93061001096 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 93061001097 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 93061001098 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 93061001099 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 93061001100 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 93061001101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 93061001102 Uncharacterized conserved protein [Function unknown]; Region: COG5609 93061001103 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 93061001104 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 93061001105 active site 93061001106 Esterase/lipase [General function prediction only]; Region: COG1647 93061001107 Putative lysophospholipase; Region: Hydrolase_4; cl19140 93061001108 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 93061001109 Na2 binding site [ion binding]; other site 93061001110 putative substrate binding site 1 [chemical binding]; other site 93061001111 Na binding site 1 [ion binding]; other site 93061001112 putative substrate binding site 2 [chemical binding]; other site 93061001113 cysteine synthase; Region: PLN02565 93061001114 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 93061001115 dimer interface [polypeptide binding]; other site 93061001116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061001117 catalytic residue [active] 93061001118 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 93061001119 homodimer interface [polypeptide binding]; other site 93061001120 substrate-cofactor binding pocket; other site 93061001121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061001122 catalytic residue [active] 93061001123 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 93061001124 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 93061001125 Walker A/P-loop; other site 93061001126 ATP binding site [chemical binding]; other site 93061001127 Q-loop/lid; other site 93061001128 ABC transporter signature motif; other site 93061001129 Walker B; other site 93061001130 D-loop; other site 93061001131 H-loop/switch region; other site 93061001132 NIL domain; Region: NIL; pfam09383 93061001133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061001134 dimer interface [polypeptide binding]; other site 93061001135 conserved gate region; other site 93061001136 ABC-ATPase subunit interface; other site 93061001137 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 93061001138 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93061001139 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 93061001140 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93061001141 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93061001142 Surface antigen [General function prediction only]; Region: COG3942 93061001143 CHAP domain; Region: CHAP; pfam05257 93061001144 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 93061001145 nudix motif; other site 93061001146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061001147 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 93061001148 Coenzyme A binding pocket [chemical binding]; other site 93061001149 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 93061001150 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 93061001151 Transcriptional regulator [Transcription]; Region: LysR; COG0583 93061001152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 93061001153 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 93061001154 dimerization interface [polypeptide binding]; other site 93061001155 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 93061001156 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 93061001157 active site 93061001158 dimer interface [polypeptide binding]; other site 93061001159 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 93061001160 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 93061001161 active site 93061001162 FMN binding site [chemical binding]; other site 93061001163 substrate binding site [chemical binding]; other site 93061001164 3Fe-4S cluster binding site [ion binding]; other site 93061001165 Glutamate synthase domain 3 [Amino acid transport and metabolism]; Region: GltB; COG0070 93061001166 domain_subunit interface; other site 93061001167 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 93061001168 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 93061001169 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 93061001170 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93061001171 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 93061001172 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 93061001173 active site turn [active] 93061001174 phosphorylation site [posttranslational modification] 93061001175 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 93061001176 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 93061001177 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 93061001178 Ca binding site [ion binding]; other site 93061001179 active site 93061001180 catalytic site [active] 93061001181 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 93061001182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 93061001183 DNA-binding site [nucleotide binding]; DNA binding site 93061001184 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 93061001185 UTRA domain; Region: UTRA; pfam07702 93061001186 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 93061001187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061001188 Coenzyme A binding pocket [chemical binding]; other site 93061001189 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 93061001190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061001191 Walker A motif; other site 93061001192 ATP binding site [chemical binding]; other site 93061001193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 93061001194 Walker B motif; other site 93061001195 arginine finger; other site 93061001196 hypothetical protein; Validated; Region: PRK00153 93061001197 recombination protein RecR; Reviewed; Region: recR; PRK00076 93061001198 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 93061001199 RecR protein; Region: RecR; pfam02132 93061001200 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 93061001201 putative active site [active] 93061001202 putative metal-binding site [ion binding]; other site 93061001203 tetramer interface [polypeptide binding]; other site 93061001204 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 93061001205 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 93061001206 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93061001207 catalytic residue [active] 93061001208 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 93061001209 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 93061001210 thymidylate kinase; Validated; Region: tmk; PRK00698 93061001211 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 93061001212 TMP-binding site; other site 93061001213 ATP-binding site [chemical binding]; other site 93061001214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 93061001215 DNA polymerase III subunit delta'; Validated; Region: PRK08485 93061001216 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 93061001217 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 93061001218 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 93061001219 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 93061001220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061001221 S-adenosylmethionine binding site [chemical binding]; other site 93061001222 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 93061001223 GIY-YIG motif/motif A; other site 93061001224 putative active site [active] 93061001225 putative metal binding site [ion binding]; other site 93061001226 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 93061001227 putative SAM binding site [chemical binding]; other site 93061001228 putative homodimer interface [polypeptide binding]; other site 93061001229 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 93061001230 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 93061001231 active site 93061001232 HIGH motif; other site 93061001233 KMSKS motif; other site 93061001234 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 93061001235 tRNA binding surface [nucleotide binding]; other site 93061001236 anticodon binding site; other site 93061001237 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 93061001238 dimer interface [polypeptide binding]; other site 93061001239 putative tRNA-binding site [nucleotide binding]; other site 93061001240 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 93061001241 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 93061001242 active site 93061001243 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 93061001244 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 93061001245 putative active site [active] 93061001246 putative metal binding site [ion binding]; other site 93061001247 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 93061001248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061001249 S-adenosylmethionine binding site [chemical binding]; other site 93061001250 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 93061001251 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 93061001252 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 93061001253 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 93061001254 pur operon repressor; Provisional; Region: PRK09213 93061001255 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 93061001256 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93061001257 active site 93061001258 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 93061001259 homotrimer interaction site [polypeptide binding]; other site 93061001260 putative active site [active] 93061001261 regulatory protein SpoVG; Reviewed; Region: PRK13259 93061001262 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 93061001263 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 93061001264 Substrate binding site; other site 93061001265 Mg++ binding site; other site 93061001266 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 93061001267 active site 93061001268 substrate binding site [chemical binding]; other site 93061001269 CoA binding site [chemical binding]; other site 93061001270 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 93061001271 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 93061001272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93061001273 active site 93061001274 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 93061001275 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 93061001276 5S rRNA interface [nucleotide binding]; other site 93061001277 CTC domain interface [polypeptide binding]; other site 93061001278 L16 interface [polypeptide binding]; other site 93061001279 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 93061001280 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 93061001281 putative active site [active] 93061001282 catalytic residue [active] 93061001283 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 93061001284 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 93061001285 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 93061001286 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93061001287 ATP binding site [chemical binding]; other site 93061001288 putative Mg++ binding site [ion binding]; other site 93061001289 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93061001290 nucleotide binding region [chemical binding]; other site 93061001291 ATP-binding site [chemical binding]; other site 93061001292 TRCF domain; Region: TRCF; pfam03461 93061001293 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 93061001294 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 93061001295 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 93061001296 putative SAM binding site [chemical binding]; other site 93061001297 putative homodimer interface [polypeptide binding]; other site 93061001298 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 93061001299 homodimer interface [polypeptide binding]; other site 93061001300 metal binding site [ion binding]; metal-binding site 93061001301 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93061001302 RNA binding surface [nucleotide binding]; other site 93061001303 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 93061001304 hypothetical protein; Provisional; Region: PRK08582 93061001305 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 93061001306 RNA binding site [nucleotide binding]; other site 93061001307 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 93061001308 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 93061001309 Ligand Binding Site [chemical binding]; other site 93061001310 TilS substrate C-terminal domain; Region: TilS_C; smart00977 93061001311 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93061001312 active site 93061001313 FtsH Extracellular; Region: FtsH_ext; pfam06480 93061001314 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 93061001315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061001316 Walker A motif; other site 93061001317 ATP binding site [chemical binding]; other site 93061001318 Walker B motif; other site 93061001319 arginine finger; other site 93061001320 Peptidase family M41; Region: Peptidase_M41; pfam01434 93061001321 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 93061001322 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 93061001323 dimerization interface [polypeptide binding]; other site 93061001324 domain crossover interface; other site 93061001325 redox-dependent activation switch; other site 93061001326 cysteine synthase; Region: PLN02565 93061001327 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 93061001328 dimer interface [polypeptide binding]; other site 93061001329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061001330 catalytic residue [active] 93061001331 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 93061001332 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 93061001333 substrate binding pocket [chemical binding]; other site 93061001334 dimer interface [polypeptide binding]; other site 93061001335 inhibitor binding site; inhibition site 93061001336 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 93061001337 homooctamer interface [polypeptide binding]; other site 93061001338 active site 93061001339 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 93061001340 catalytic center binding site [active] 93061001341 ATP binding site [chemical binding]; other site 93061001342 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 93061001343 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 93061001344 dimer interface [polypeptide binding]; other site 93061001345 putative anticodon binding site; other site 93061001346 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 93061001347 motif 1; other site 93061001348 active site 93061001349 motif 2; other site 93061001350 motif 3; other site 93061001351 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 93061001352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 93061001353 DNA-binding site [nucleotide binding]; DNA binding site 93061001354 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93061001355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061001356 homodimer interface [polypeptide binding]; other site 93061001357 catalytic residue [active] 93061001358 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 93061001359 active site 93061001360 multimer interface [polypeptide binding]; other site 93061001361 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 93061001362 predicted active site [active] 93061001363 catalytic triad [active] 93061001364 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 93061001365 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 93061001366 Nucleoside recognition; Region: Gate; pfam07670 93061001367 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 93061001368 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 93061001369 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 93061001370 UvrB/uvrC motif; Region: UVR; pfam02151 93061001371 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 93061001372 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 93061001373 ADP binding site [chemical binding]; other site 93061001374 phosphagen binding site; other site 93061001375 substrate specificity loop; other site 93061001376 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 93061001377 Clp amino terminal domain; Region: Clp_N; pfam02861 93061001378 Clp amino terminal domain; Region: Clp_N; pfam02861 93061001379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061001380 Walker A motif; other site 93061001381 ATP binding site [chemical binding]; other site 93061001382 Walker B motif; other site 93061001383 arginine finger; other site 93061001384 PCI domain; Region: PCI; cl02111 93061001385 UvrB/uvrC motif; Region: UVR; pfam02151 93061001386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061001387 Walker A motif; other site 93061001388 ATP binding site [chemical binding]; other site 93061001389 Walker B motif; other site 93061001390 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 93061001391 DNA repair protein RadA; Provisional; Region: PRK11823 93061001392 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 93061001393 Walker A motif/ATP binding site; other site 93061001394 ATP binding site [chemical binding]; other site 93061001395 Walker B motif; other site 93061001396 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 93061001397 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 93061001398 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 93061001399 putative active site [active] 93061001400 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 93061001401 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 93061001402 active site 93061001403 HIGH motif; other site 93061001404 KMSKS motif; other site 93061001405 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 93061001406 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 93061001407 trimer interface [polypeptide binding]; other site 93061001408 active site 93061001409 substrate binding site [chemical binding]; other site 93061001410 CoA binding site [chemical binding]; other site 93061001411 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 93061001412 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 93061001413 active site 93061001414 HIGH motif; other site 93061001415 KMSKS motif; other site 93061001416 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 93061001417 tRNA binding surface [nucleotide binding]; other site 93061001418 anticodon binding site; other site 93061001419 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 93061001420 dimerization interface [polypeptide binding]; other site 93061001421 active site 93061001422 metal binding site [ion binding]; metal-binding site 93061001423 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 93061001424 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 93061001425 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 93061001426 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 93061001427 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 93061001428 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 93061001429 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 93061001430 DNA binding residues [nucleotide binding] 93061001431 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 93061001432 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 93061001433 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 93061001434 putative homodimer interface [polypeptide binding]; other site 93061001435 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 93061001436 heterodimer interface [polypeptide binding]; other site 93061001437 homodimer interface [polypeptide binding]; other site 93061001438 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 93061001439 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 93061001440 23S rRNA interface [nucleotide binding]; other site 93061001441 L7/L12 interface [polypeptide binding]; other site 93061001442 putative thiostrepton binding site; other site 93061001443 L25 interface [polypeptide binding]; other site 93061001444 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 93061001445 mRNA/rRNA interface [nucleotide binding]; other site 93061001446 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 93061001447 23S rRNA interface [nucleotide binding]; other site 93061001448 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 93061001449 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 93061001450 peripheral dimer interface [polypeptide binding]; other site 93061001451 core dimer interface [polypeptide binding]; other site 93061001452 L10 interface [polypeptide binding]; other site 93061001453 L11 interface [polypeptide binding]; other site 93061001454 putative EF-Tu interaction site [polypeptide binding]; other site 93061001455 putative EF-G interaction site [polypeptide binding]; other site 93061001456 Methyltransferase domain; Region: Methyltransf_31; pfam13847 93061001457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061001458 S-adenosylmethionine binding site [chemical binding]; other site 93061001459 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 93061001460 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 93061001461 RPB12 interaction site [polypeptide binding]; other site 93061001462 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 93061001463 RPB1 interaction site [polypeptide binding]; other site 93061001464 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 93061001465 RPB10 interaction site [polypeptide binding]; other site 93061001466 RPB11 interaction site [polypeptide binding]; other site 93061001467 RPB3 interaction site [polypeptide binding]; other site 93061001468 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 93061001469 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 93061001470 beta and beta' interface [polypeptide binding]; other site 93061001471 beta' and sigma factor interface [polypeptide binding]; other site 93061001472 Zn-binding [ion binding]; other site 93061001473 active site region [active] 93061001474 catalytic site [active] 93061001475 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 93061001476 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 93061001477 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 93061001478 G-loop; other site 93061001479 DNA binding site [nucleotide binding] 93061001480 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 93061001481 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 93061001482 S17 interaction site [polypeptide binding]; other site 93061001483 S8 interaction site; other site 93061001484 16S rRNA interaction site [nucleotide binding]; other site 93061001485 streptomycin interaction site [chemical binding]; other site 93061001486 23S rRNA interaction site [nucleotide binding]; other site 93061001487 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 93061001488 30S ribosomal protein S7; Validated; Region: PRK05302 93061001489 elongation factor G; Reviewed; Region: PRK00007 93061001490 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 93061001491 G1 box; other site 93061001492 putative GEF interaction site [polypeptide binding]; other site 93061001493 GTP/Mg2+ binding site [chemical binding]; other site 93061001494 Switch I region; other site 93061001495 G2 box; other site 93061001496 G3 box; other site 93061001497 Switch II region; other site 93061001498 G4 box; other site 93061001499 G5 box; other site 93061001500 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 93061001501 Elongation Factor G, domain II; Region: EFG_II; pfam14492 93061001502 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 93061001503 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 93061001504 elongation factor Tu; Reviewed; Region: PRK00049 93061001505 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 93061001506 G1 box; other site 93061001507 GEF interaction site [polypeptide binding]; other site 93061001508 GTP/Mg2+ binding site [chemical binding]; other site 93061001509 Switch I region; other site 93061001510 G2 box; other site 93061001511 G3 box; other site 93061001512 Switch II region; other site 93061001513 G4 box; other site 93061001514 G5 box; other site 93061001515 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 93061001516 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 93061001517 Antibiotic Binding Site [chemical binding]; other site 93061001518 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 93061001519 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 93061001520 metal binding site [ion binding]; metal-binding site 93061001521 dimer interface [polypeptide binding]; other site 93061001522 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 93061001523 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 93061001524 substrate-cofactor binding pocket; other site 93061001525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061001526 catalytic residue [active] 93061001527 chaperone protein HchA; Provisional; Region: PRK04155 93061001528 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 93061001529 dimer interface [polypeptide binding]; other site 93061001530 metal binding site [ion binding]; metal-binding site 93061001531 potential oxyanion hole; other site 93061001532 potential catalytic triad [active] 93061001533 conserved cys residue [active] 93061001534 ribulokinase; Provisional; Region: PRK04123 93061001535 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 93061001536 N- and C-terminal domain interface [polypeptide binding]; other site 93061001537 active site 93061001538 MgATP binding site [chemical binding]; other site 93061001539 catalytic site [active] 93061001540 metal binding site [ion binding]; metal-binding site 93061001541 carbohydrate binding site [chemical binding]; other site 93061001542 homodimer interface [polypeptide binding]; other site 93061001543 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93061001544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93061001545 NAD(P) binding site [chemical binding]; other site 93061001546 active site 93061001547 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 93061001548 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 93061001549 homodimer interface [polypeptide binding]; other site 93061001550 substrate-cofactor binding pocket; other site 93061001551 catalytic residue [active] 93061001552 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 93061001553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061001554 motif II; other site 93061001555 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 93061001556 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 93061001557 Substrate-binding site [chemical binding]; other site 93061001558 Substrate specificity [chemical binding]; other site 93061001559 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 93061001560 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 93061001561 Substrate-binding site [chemical binding]; other site 93061001562 Substrate specificity [chemical binding]; other site 93061001563 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 93061001564 nucleoside/Zn binding site; other site 93061001565 dimer interface [polypeptide binding]; other site 93061001566 catalytic motif [active] 93061001567 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061001568 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 93061001569 active site 93061001570 motif I; other site 93061001571 motif II; other site 93061001572 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 93061001573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061001574 Predicted flavoprotein [General function prediction only]; Region: COG0431 93061001575 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 93061001576 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 93061001577 Cna protein B-type domain; Region: Cna_B; pfam05738 93061001578 Cna protein B-type domain; Region: Cna_B; pfam05738 93061001579 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 93061001580 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 93061001581 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 93061001582 Cna protein B-type domain; Region: Cna_B; pfam05738 93061001583 Cna protein B-type domain; Region: Cna_B; pfam05738 93061001584 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 93061001585 Cna protein B-type domain; Region: Cna_B; pfam05738 93061001586 Cna protein B-type domain; Region: Cna_B; pfam05738 93061001587 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 93061001588 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 93061001589 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 93061001590 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 93061001591 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 93061001592 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 93061001593 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 93061001594 putative GTP cyclohydrolase; Provisional; Region: PRK13674 93061001595 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 93061001596 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 93061001597 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 93061001598 active site 93061001599 trimer interface [polypeptide binding]; other site 93061001600 allosteric site; other site 93061001601 active site lid [active] 93061001602 hexamer (dimer of trimers) interface [polypeptide binding]; other site 93061001603 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 93061001604 active site 93061001605 dimer interface [polypeptide binding]; other site 93061001606 magnesium binding site [ion binding]; other site 93061001607 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 93061001608 tetramer interface [polypeptide binding]; other site 93061001609 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 93061001610 active site 93061001611 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 93061001612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061001613 motif II; other site 93061001614 proline/glycine betaine transporter; Provisional; Region: PRK10642 93061001615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061001616 putative substrate translocation pore; other site 93061001617 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 93061001618 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 93061001619 acyl-activating enzyme (AAE) consensus motif; other site 93061001620 AMP binding site [chemical binding]; other site 93061001621 active site 93061001622 CoA binding site [chemical binding]; other site 93061001623 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 93061001624 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 93061001625 dimer interface [polypeptide binding]; other site 93061001626 active site 93061001627 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 93061001628 dimer interface [polypeptide binding]; other site 93061001629 substrate binding site [chemical binding]; other site 93061001630 ATP binding site [chemical binding]; other site 93061001631 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 93061001632 ligand binding site [chemical binding]; other site 93061001633 active site 93061001634 UGI interface [polypeptide binding]; other site 93061001635 catalytic site [active] 93061001636 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 93061001637 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 93061001638 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 93061001639 Uncharacterized conserved protein [Function unknown]; Region: COG3610 93061001640 Uncharacterized conserved protein [Function unknown]; Region: COG2966 93061001641 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 93061001642 putative heme peroxidase; Provisional; Region: PRK12276 93061001643 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 93061001644 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 93061001645 mevalonate kinase; Region: mevalon_kin; TIGR00549 93061001646 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 93061001647 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 93061001648 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 93061001649 diphosphomevalonate decarboxylase; Region: PLN02407 93061001650 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 93061001651 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 93061001652 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 93061001653 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 93061001654 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 93061001655 Squalene epoxidase; Region: SE; cl17314 93061001656 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93061001657 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 93061001658 Predicted transcriptional regulator [Transcription]; Region: COG1959 93061001659 Rrf2 family protein; Region: rrf2_super; TIGR00738 93061001660 LXG domain of WXG superfamily; Region: LXG; pfam04740 93061001661 Protein of unknown function (DUF443); Region: DUF443; pfam04276 93061001662 Protein of unknown function (DUF443); Region: DUF443; pfam04276 93061001663 Protein of unknown function (DUF443); Region: DUF443; pfam04276 93061001664 Protein of unknown function (DUF443); Region: DUF443; pfam04276 93061001665 Protein of unknown function (DUF443); Region: DUF443; pfam04276 93061001666 Protein of unknown function (DUF443); Region: DUF443; pfam04276 93061001667 Protein of unknown function (DUF443); Region: DUF443; pfam04276 93061001668 Protein of unknown function (DUF443); Region: DUF443; pfam04276 93061001669 Protein of unknown function (DUF443); Region: DUF443; pfam04276 93061001670 Protein of unknown function (DUF443); Region: DUF443; pfam04276 93061001671 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 93061001672 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 93061001673 active site 93061001674 catalytic tetrad [active] 93061001675 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 93061001676 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 93061001677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061001678 Coenzyme A binding pocket [chemical binding]; other site 93061001679 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 93061001680 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 93061001681 Zn2+ binding site [ion binding]; other site 93061001682 Mg2+ binding site [ion binding]; other site 93061001683 YwhD family; Region: YwhD; pfam08741 93061001684 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 93061001685 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 93061001686 NAD binding site [chemical binding]; other site 93061001687 substrate binding site [chemical binding]; other site 93061001688 catalytic Zn binding site [ion binding]; other site 93061001689 tetramer interface [polypeptide binding]; other site 93061001690 structural Zn binding site [ion binding]; other site 93061001691 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 93061001692 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 93061001693 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 93061001694 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 93061001695 active site 93061001696 HIGH motif; other site 93061001697 KMSK motif region; other site 93061001698 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 93061001699 tRNA binding surface [nucleotide binding]; other site 93061001700 anticodon binding site; other site 93061001701 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 93061001702 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 93061001703 minor groove reading motif; other site 93061001704 helix-hairpin-helix signature motif; other site 93061001705 substrate binding pocket [chemical binding]; other site 93061001706 active site 93061001707 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 93061001708 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 93061001709 putative binding site residues; other site 93061001710 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 93061001711 ABC-ATPase subunit interface; other site 93061001712 dimer interface [polypeptide binding]; other site 93061001713 putative PBP binding regions; other site 93061001714 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 93061001715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061001716 motif II; other site 93061001717 Putative lysophospholipase; Region: Hydrolase_4; cl19140 93061001718 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 93061001719 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 93061001720 Putative lysophospholipase; Region: Hydrolase_4; cl19140 93061001721 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 93061001722 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061001723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 93061001724 Protein of unknown function, DUF606; Region: DUF606; pfam04657 93061001725 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 93061001726 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 93061001727 active site 93061001728 DNA binding site [nucleotide binding] 93061001729 Int/Topo IB signature motif; other site 93061001730 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 93061001731 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 93061001732 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 93061001733 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 93061001734 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 93061001735 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 93061001736 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 93061001737 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 93061001738 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 93061001739 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 93061001740 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 93061001741 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 93061001742 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 93061001743 metal binding site [ion binding]; metal-binding site 93061001744 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 93061001745 ABC-ATPase subunit interface; other site 93061001746 dimer interface [polypeptide binding]; other site 93061001747 putative PBP binding regions; other site 93061001748 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 93061001749 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 93061001750 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 93061001751 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 93061001752 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 93061001753 FeoA domain; Region: FeoA; pfam04023 93061001754 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 93061001755 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 93061001756 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 93061001757 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 93061001758 Walker A/P-loop; other site 93061001759 ATP binding site [chemical binding]; other site 93061001760 Q-loop/lid; other site 93061001761 ABC transporter signature motif; other site 93061001762 Walker B; other site 93061001763 D-loop; other site 93061001764 H-loop/switch region; other site 93061001765 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 93061001766 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 93061001767 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 93061001768 active site 93061001769 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 93061001770 active site 93061001771 nucleotide binding site [chemical binding]; other site 93061001772 HIGH motif; other site 93061001773 KMSKS motif; other site 93061001774 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 93061001775 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 93061001776 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 93061001777 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 93061001778 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93061001779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061001780 Walker A/P-loop; other site 93061001781 ATP binding site [chemical binding]; other site 93061001782 Q-loop/lid; other site 93061001783 ABC transporter signature motif; other site 93061001784 Walker B; other site 93061001785 D-loop; other site 93061001786 H-loop/switch region; other site 93061001787 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 93061001788 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 93061001789 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 93061001790 Uncharacterized conserved protein [Function unknown]; Region: COG1284 93061001791 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 93061001792 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 93061001793 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 93061001794 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 93061001795 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 93061001796 Walker A/P-loop; other site 93061001797 ATP binding site [chemical binding]; other site 93061001798 Q-loop/lid; other site 93061001799 ABC transporter signature motif; other site 93061001800 Walker B; other site 93061001801 D-loop; other site 93061001802 H-loop/switch region; other site 93061001803 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 93061001804 ABC-ATPase subunit interface; other site 93061001805 dimer interface [polypeptide binding]; other site 93061001806 putative PBP binding regions; other site 93061001807 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 93061001808 ABC-ATPase subunit interface; other site 93061001809 dimer interface [polypeptide binding]; other site 93061001810 putative PBP binding regions; other site 93061001811 Dak1 domain; Region: Dak1; cl10557 93061001812 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 93061001813 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 93061001814 Uncharacterized membrane protein [Function unknown]; Region: COG3949 93061001815 Na binding site [ion binding]; other site 93061001816 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 93061001817 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 93061001818 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 93061001819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061001820 Coenzyme A binding pocket [chemical binding]; other site 93061001821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 93061001822 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93061001823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93061001824 NAD(P) binding site [chemical binding]; other site 93061001825 active site 93061001826 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 93061001827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061001828 active site 93061001829 phosphorylation site [posttranslational modification] 93061001830 intermolecular recognition site; other site 93061001831 dimerization interface [polypeptide binding]; other site 93061001832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93061001833 DNA binding site [nucleotide binding] 93061001834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 93061001835 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 93061001836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061001837 ATP binding site [chemical binding]; other site 93061001838 Mg2+ binding site [ion binding]; other site 93061001839 G-X-G motif; other site 93061001840 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 93061001841 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 93061001842 Walker A/P-loop; other site 93061001843 ATP binding site [chemical binding]; other site 93061001844 Q-loop/lid; other site 93061001845 ABC transporter signature motif; other site 93061001846 Walker B; other site 93061001847 D-loop; other site 93061001848 H-loop/switch region; other site 93061001849 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 93061001850 TIGR00153 family protein; Region: TIGR00153 93061001851 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 93061001852 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93061001853 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 93061001854 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93061001855 Surface antigen [General function prediction only]; Region: COG3942 93061001856 CHAP domain; Region: CHAP; pfam05257 93061001857 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 93061001858 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 93061001859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 93061001860 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 93061001861 hypothetical protein; Provisional; Region: PRK12378 93061001862 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 93061001863 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 93061001864 Transcriptional regulator [Transcription]; Region: LysR; COG0583 93061001865 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 93061001866 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 93061001867 dimerization interface [polypeptide binding]; other site 93061001868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061001869 sugar efflux transporter; Region: 2A0120; TIGR00899 93061001870 putative substrate translocation pore; other site 93061001871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 93061001872 Serine incorporator (Serinc); Region: Serinc; pfam03348 93061001873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061001874 Coenzyme A binding pocket [chemical binding]; other site 93061001875 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 93061001876 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 93061001877 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 93061001878 hypothetical protein; Validated; Region: PRK00124 93061001879 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 93061001880 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 93061001881 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 93061001882 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93061001883 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 93061001884 Walker A/P-loop; other site 93061001885 ATP binding site [chemical binding]; other site 93061001886 Q-loop/lid; other site 93061001887 ABC transporter signature motif; other site 93061001888 Walker B; other site 93061001889 D-loop; other site 93061001890 H-loop/switch region; other site 93061001891 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 93061001892 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93061001893 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 93061001894 Walker A/P-loop; other site 93061001895 ATP binding site [chemical binding]; other site 93061001896 Q-loop/lid; other site 93061001897 ABC transporter signature motif; other site 93061001898 Walker B; other site 93061001899 D-loop; other site 93061001900 H-loop/switch region; other site 93061001901 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061001902 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 93061001903 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 93061001904 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 93061001905 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 93061001906 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 93061001907 active site 93061001908 catalytic tetrad [active] 93061001909 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 93061001910 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 93061001911 transmembrane helices; other site 93061001912 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 93061001913 DNA photolyase; Region: DNA_photolyase; pfam00875 93061001914 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 93061001915 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 93061001916 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 93061001917 trimer interface [polypeptide binding]; other site 93061001918 putative Zn binding site [ion binding]; other site 93061001919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061001920 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061001921 putative substrate translocation pore; other site 93061001922 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 93061001923 putative deacylase active site [active] 93061001924 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 93061001925 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 93061001926 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 93061001927 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 93061001928 putative substrate binding site [chemical binding]; other site 93061001929 putative ATP binding site [chemical binding]; other site 93061001930 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 93061001931 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 93061001932 active site 93061001933 phosphorylation site [posttranslational modification] 93061001934 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 93061001935 active site 93061001936 P-loop; other site 93061001937 phosphorylation site [posttranslational modification] 93061001938 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 93061001939 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 93061001940 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 93061001941 active site 93061001942 dimer interface [polypeptide binding]; other site 93061001943 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 93061001944 Domain of unknown function DUF21; Region: DUF21; pfam01595 93061001945 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 93061001946 Transporter associated domain; Region: CorC_HlyC; pfam03471 93061001947 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 93061001948 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 93061001949 active site 93061001950 catalytic tetrad [active] 93061001951 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 93061001952 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 93061001953 Ligand binding site; other site 93061001954 Putative Catalytic site; other site 93061001955 DXD motif; other site 93061001956 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 93061001957 HAMP domain; Region: HAMP; pfam00672 93061001958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 93061001959 dimer interface [polypeptide binding]; other site 93061001960 phosphorylation site [posttranslational modification] 93061001961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061001962 ATP binding site [chemical binding]; other site 93061001963 Mg2+ binding site [ion binding]; other site 93061001964 G-X-G motif; other site 93061001965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 93061001966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061001967 active site 93061001968 phosphorylation site [posttranslational modification] 93061001969 intermolecular recognition site; other site 93061001970 dimerization interface [polypeptide binding]; other site 93061001971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93061001972 DNA binding site [nucleotide binding] 93061001973 Predicted membrane protein [Function unknown]; Region: COG2259 93061001974 Electron transfer DM13; Region: DM13; pfam10517 93061001975 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 93061001976 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 93061001977 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 93061001978 active site 93061001979 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 93061001980 Ligand Binding Site [chemical binding]; other site 93061001981 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 93061001982 Glutamine amidotransferase class-I; Region: GATase; pfam00117 93061001983 glutamine binding [chemical binding]; other site 93061001984 catalytic triad [active] 93061001985 aminodeoxychorismate synthase; Provisional; Region: PRK07508 93061001986 chorismate binding enzyme; Region: Chorismate_bind; cl10555 93061001987 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 93061001988 substrate-cofactor binding pocket; other site 93061001989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061001990 catalytic residue [active] 93061001991 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 93061001992 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 93061001993 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 93061001994 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 93061001995 Sulfatase; Region: Sulfatase; pfam00884 93061001996 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 93061001997 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 93061001998 ABC transporter; Region: ABC_tran_2; pfam12848 93061001999 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 93061002000 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 93061002001 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93061002002 ATP binding site [chemical binding]; other site 93061002003 putative Mg++ binding site [ion binding]; other site 93061002004 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93061002005 nucleotide binding region [chemical binding]; other site 93061002006 ATP-binding site [chemical binding]; other site 93061002007 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 93061002008 HRDC domain; Region: HRDC; pfam00570 93061002009 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 93061002010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061002011 Walker A/P-loop; other site 93061002012 ATP binding site [chemical binding]; other site 93061002013 Q-loop/lid; other site 93061002014 ABC transporter signature motif; other site 93061002015 Walker B; other site 93061002016 D-loop; other site 93061002017 H-loop/switch region; other site 93061002018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061002019 dimer interface [polypeptide binding]; other site 93061002020 conserved gate region; other site 93061002021 putative PBP binding loops; other site 93061002022 ABC-ATPase subunit interface; other site 93061002023 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 93061002024 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 93061002025 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93061002026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061002027 homodimer interface [polypeptide binding]; other site 93061002028 catalytic residue [active] 93061002029 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 93061002030 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 93061002031 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 93061002032 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 93061002033 POT family; Region: PTR2; cl17359 93061002034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061002035 putative substrate translocation pore; other site 93061002036 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 93061002037 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 93061002038 EamA-like transporter family; Region: EamA; pfam00892 93061002039 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 93061002040 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 93061002041 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 93061002042 Class I ribonucleotide reductase; Region: RNR_I; cd01679 93061002043 active site 93061002044 dimer interface [polypeptide binding]; other site 93061002045 catalytic residues [active] 93061002046 effector binding site; other site 93061002047 R2 peptide binding site; other site 93061002048 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 93061002049 dimer interface [polypeptide binding]; other site 93061002050 putative radical transfer pathway; other site 93061002051 diiron center [ion binding]; other site 93061002052 tyrosyl radical; other site 93061002053 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 93061002054 ABC-ATPase subunit interface; other site 93061002055 dimer interface [polypeptide binding]; other site 93061002056 putative PBP binding regions; other site 93061002057 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 93061002058 ABC-ATPase subunit interface; other site 93061002059 dimer interface [polypeptide binding]; other site 93061002060 putative PBP binding regions; other site 93061002061 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 93061002062 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 93061002063 Walker A/P-loop; other site 93061002064 ATP binding site [chemical binding]; other site 93061002065 Q-loop/lid; other site 93061002066 ABC transporter signature motif; other site 93061002067 Walker B; other site 93061002068 D-loop; other site 93061002069 H-loop/switch region; other site 93061002070 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 93061002071 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 93061002072 putative ligand binding residues [chemical binding]; other site 93061002073 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 93061002074 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 93061002075 FAD binding domain; Region: FAD_binding_4; pfam01565 93061002076 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 93061002077 GrpB protein; Region: GrpB; pfam04229 93061002078 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 93061002079 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 93061002080 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 93061002081 peptidase T-like protein; Region: PepT-like; TIGR01883 93061002082 metal binding site [ion binding]; metal-binding site 93061002083 dimer interface [polypeptide binding]; other site 93061002084 Uncharacterized conserved protein [Function unknown]; Region: COG3610 93061002085 Uncharacterized conserved protein [Function unknown]; Region: COG2966 93061002086 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 93061002087 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 93061002088 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 93061002089 metal binding site [ion binding]; metal-binding site 93061002090 active site 93061002091 I-site; other site 93061002092 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 93061002093 Mg++ binding site [ion binding]; other site 93061002094 putative catalytic motif [active] 93061002095 substrate binding site [chemical binding]; other site 93061002096 Uncharacterized conserved protein [Function unknown]; Region: COG1739 93061002097 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 93061002098 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 93061002099 Uncharacterized protein, DegV family COG1307; Region: DegV; cl19360 93061002100 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 93061002101 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93061002102 ATP binding site [chemical binding]; other site 93061002103 putative Mg++ binding site [ion binding]; other site 93061002104 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93061002105 nucleotide binding region [chemical binding]; other site 93061002106 ATP-binding site [chemical binding]; other site 93061002107 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 93061002108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93061002109 active site 93061002110 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 93061002111 30S subunit binding site; other site 93061002112 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 93061002113 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 93061002114 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 93061002115 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93061002116 nucleotide binding region [chemical binding]; other site 93061002117 ATP-binding site [chemical binding]; other site 93061002118 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 93061002119 SEC-C motif; Region: SEC-C; pfam02810 93061002120 This domain is found in peptide chain release factors; Region: PCRF; smart00937 93061002121 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 93061002122 RF-1 domain; Region: RF-1; pfam00472 93061002123 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 93061002124 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93061002125 Surface antigen [General function prediction only]; Region: COG3942 93061002126 CHAP domain; Region: CHAP; pfam05257 93061002127 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 93061002128 Zn2+ binding site [ion binding]; other site 93061002129 Mg2+ binding site [ion binding]; other site 93061002130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 93061002131 excinuclease ABC subunit B; Provisional; Region: PRK05298 93061002132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93061002133 ATP binding site [chemical binding]; other site 93061002134 Transposase domain (DUF772); Region: DUF772; pfam05598 93061002135 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 93061002136 DDE superfamily endonuclease; Region: DDE_Tnp_4; cl17710 93061002137 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 93061002138 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93061002139 nucleotide binding region [chemical binding]; other site 93061002140 ATP-binding site [chemical binding]; other site 93061002141 Ultra-violet resistance protein B; Region: UvrB; pfam12344 93061002142 UvrB/uvrC motif; Region: UVR; pfam02151 93061002143 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 93061002144 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 93061002145 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 93061002146 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 93061002147 HPr kinase/phosphorylase; Provisional; Region: PRK05428 93061002148 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 93061002149 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 93061002150 Hpr binding site; other site 93061002151 active site 93061002152 homohexamer subunit interaction site [polypeptide binding]; other site 93061002153 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 93061002154 putative acyl transferase; Provisional; Region: PRK10191 93061002155 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 93061002156 putative trimer interface [polypeptide binding]; other site 93061002157 putative CoA binding site [chemical binding]; other site 93061002158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93061002159 binding surface 93061002160 TPR motif; other site 93061002161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93061002162 TPR motif; other site 93061002163 binding surface 93061002164 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 93061002165 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 93061002166 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93061002167 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 93061002168 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 93061002169 phosphate binding site [ion binding]; other site 93061002170 dimer interface [polypeptide binding]; other site 93061002171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 93061002172 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 93061002173 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 93061002174 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 93061002175 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 93061002176 oligomer interface [polypeptide binding]; other site 93061002177 active site residues [active] 93061002178 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 93061002179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93061002180 NAD(P) binding site [chemical binding]; other site 93061002181 active site 93061002182 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 93061002183 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 93061002184 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 93061002185 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 93061002186 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 93061002187 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 93061002188 substrate binding site [chemical binding]; other site 93061002189 hinge regions; other site 93061002190 ADP binding site [chemical binding]; other site 93061002191 catalytic site [active] 93061002192 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 93061002193 substrate binding site [chemical binding]; other site 93061002194 dimer interface [polypeptide binding]; other site 93061002195 catalytic triad [active] 93061002196 phosphoglyceromutase; Provisional; Region: PRK05434 93061002197 enolase; Provisional; Region: eno; PRK00077 93061002198 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 93061002199 dimer interface [polypeptide binding]; other site 93061002200 metal binding site [ion binding]; metal-binding site 93061002201 substrate binding pocket [chemical binding]; other site 93061002202 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 93061002203 Esterase/lipase [General function prediction only]; Region: COG1647 93061002204 Baculovirus DNA helicase; Region: Baculo_helicase; pfam04735 93061002205 ribonuclease R; Region: RNase_R; TIGR02063 93061002206 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 93061002207 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 93061002208 RNB domain; Region: RNB; pfam00773 93061002209 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 93061002210 RNA binding site [nucleotide binding]; other site 93061002211 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 93061002212 SmpB-tmRNA interface; other site 93061002213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061002214 Coenzyme A binding pocket [chemical binding]; other site 93061002215 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 93061002216 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 93061002217 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 93061002218 Staphylococcal nuclease homologues; Region: SNc; smart00318 93061002219 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 93061002220 Catalytic site; other site 93061002221 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 93061002222 DNA-binding site [nucleotide binding]; DNA binding site 93061002223 RNA-binding motif; other site 93061002224 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 93061002225 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 93061002226 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 93061002227 catalytic core [active] 93061002228 Lysine efflux permease [General function prediction only]; Region: COG1279 93061002229 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 93061002230 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 93061002231 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 93061002232 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 93061002233 active site 93061002234 catalytic residue [active] 93061002235 dimer interface [polypeptide binding]; other site 93061002236 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 93061002237 FMN binding site [chemical binding]; other site 93061002238 dimer interface [polypeptide binding]; other site 93061002239 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 93061002240 catalytic residues [active] 93061002241 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 93061002242 putative ArsC-like catalytic residues; other site 93061002243 putative TRX-like catalytic residues [active] 93061002244 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 93061002245 lipoyl attachment site [posttranslational modification]; other site 93061002246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 93061002247 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 93061002248 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 93061002249 putative active site [active] 93061002250 putative metal binding site [ion binding]; other site 93061002251 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 93061002252 catalytic residues [active] 93061002253 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 93061002254 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 93061002255 Walker A/P-loop; other site 93061002256 ATP binding site [chemical binding]; other site 93061002257 Q-loop/lid; other site 93061002258 ABC transporter signature motif; other site 93061002259 Walker B; other site 93061002260 D-loop; other site 93061002261 H-loop/switch region; other site 93061002262 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 93061002263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061002264 dimer interface [polypeptide binding]; other site 93061002265 conserved gate region; other site 93061002266 putative PBP binding loops; other site 93061002267 ABC-ATPase subunit interface; other site 93061002268 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 93061002269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 93061002270 Predicted membrane protein [Function unknown]; Region: COG2035 93061002271 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 93061002272 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 93061002273 Walker A/P-loop; other site 93061002274 ATP binding site [chemical binding]; other site 93061002275 Q-loop/lid; other site 93061002276 ABC transporter signature motif; other site 93061002277 Walker B; other site 93061002278 D-loop; other site 93061002279 H-loop/switch region; other site 93061002280 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 93061002281 FeS assembly protein SufD; Region: sufD; TIGR01981 93061002282 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 93061002283 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93061002284 catalytic residue [active] 93061002285 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 93061002286 trimerization site [polypeptide binding]; other site 93061002287 active site 93061002288 FeS assembly protein SufB; Region: sufB; TIGR01980 93061002289 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 93061002290 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 93061002291 Domain of unknown function DUF21; Region: DUF21; pfam01595 93061002292 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 93061002293 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 93061002294 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 93061002295 FMN binding site [chemical binding]; other site 93061002296 substrate binding site [chemical binding]; other site 93061002297 putative catalytic residue [active] 93061002298 Uncharacterized conserved protein [Function unknown]; Region: COG1801 93061002299 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 93061002300 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 93061002301 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 93061002302 active site 93061002303 metal binding site [ion binding]; metal-binding site 93061002304 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 93061002305 lipoyl synthase; Provisional; Region: PRK05481 93061002306 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93061002307 FeS/SAM binding site; other site 93061002308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 93061002309 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 93061002310 Uncharacterized conserved protein [Function unknown]; Region: COG2445 93061002311 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 93061002312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061002313 active site 93061002314 motif I; other site 93061002315 motif II; other site 93061002316 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 93061002317 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 93061002318 dimerization interface [polypeptide binding]; other site 93061002319 ligand binding site [chemical binding]; other site 93061002320 NADP binding site [chemical binding]; other site 93061002321 catalytic site [active] 93061002322 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 93061002323 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 93061002324 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 93061002325 acyl-activating enzyme (AAE) consensus motif; other site 93061002326 AMP binding site [chemical binding]; other site 93061002327 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 93061002328 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 93061002329 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 93061002330 DltD N-terminal region; Region: DltD_N; pfam04915 93061002331 DltD central region; Region: DltD_M; pfam04918 93061002332 DltD C-terminal region; Region: DltD_C; pfam04914 93061002333 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 93061002334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 93061002335 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 93061002336 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93061002337 hypothetical protein; Provisional; Region: PRK13669 93061002338 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 93061002339 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 93061002340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93061002341 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 93061002342 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 93061002343 interface (dimer of trimers) [polypeptide binding]; other site 93061002344 Substrate-binding/catalytic site; other site 93061002345 Zn-binding sites [ion binding]; other site 93061002346 Predicted permease [General function prediction only]; Region: COG2056 93061002347 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 93061002348 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 93061002349 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 93061002350 CoenzymeA binding site [chemical binding]; other site 93061002351 subunit interaction site [polypeptide binding]; other site 93061002352 PHB binding site; other site 93061002353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 93061002354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 93061002355 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 93061002356 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 93061002357 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 93061002358 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 93061002359 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 93061002360 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 93061002361 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 93061002362 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 93061002363 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 93061002364 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 93061002365 Kinase associated protein B; Region: KapB; pfam08810 93061002366 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 93061002367 active site 93061002368 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 93061002369 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 93061002370 RNA binding site [nucleotide binding]; other site 93061002371 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 93061002372 putative active site [active] 93061002373 putative FMN binding site [chemical binding]; other site 93061002374 putative substrate binding site [chemical binding]; other site 93061002375 putative catalytic residue [active] 93061002376 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 93061002377 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 93061002378 inhibitor-cofactor binding pocket; inhibition site 93061002379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061002380 catalytic residue [active] 93061002381 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 93061002382 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 93061002383 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 93061002384 NAD(P) binding site [chemical binding]; other site 93061002385 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 93061002386 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 93061002387 active site 93061002388 catalytic site [active] 93061002389 metal binding site [ion binding]; metal-binding site 93061002390 argininosuccinate lyase; Provisional; Region: PRK00855 93061002391 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 93061002392 active sites [active] 93061002393 tetramer interface [polypeptide binding]; other site 93061002394 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 93061002395 ANP binding site [chemical binding]; other site 93061002396 Substrate Binding Site II [chemical binding]; other site 93061002397 Substrate Binding Site I [chemical binding]; other site 93061002398 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 93061002399 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 93061002400 active site 93061002401 dimer interface [polypeptide binding]; other site 93061002402 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 93061002403 dimer interface [polypeptide binding]; other site 93061002404 active site 93061002405 Uncharacterized conserved protein [Function unknown]; Region: COG0398 93061002406 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 93061002407 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 93061002408 Catalytic site [active] 93061002409 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 93061002410 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 93061002411 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 93061002412 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 93061002413 Catalytic site [active] 93061002414 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 93061002415 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 93061002416 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 93061002417 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 93061002418 Part of AAA domain; Region: AAA_19; pfam13245 93061002419 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 93061002420 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 93061002421 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 93061002422 hypothetical protein; Provisional; Region: PRK13673 93061002423 coenzyme A disulfide reductase; Provisional; Region: PRK13512 93061002424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 93061002425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93061002426 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 93061002427 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 93061002428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061002429 active site 93061002430 motif I; other site 93061002431 motif II; other site 93061002432 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 93061002433 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 93061002434 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 93061002435 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 93061002436 catalytic triad [active] 93061002437 catalytic triad [active] 93061002438 oxyanion hole [active] 93061002439 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 93061002440 Clp amino terminal domain; Region: Clp_N; pfam02861 93061002441 Clp amino terminal domain; Region: Clp_N; pfam02861 93061002442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061002443 Walker A motif; other site 93061002444 ATP binding site [chemical binding]; other site 93061002445 Walker B motif; other site 93061002446 arginine finger; other site 93061002447 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 93061002448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061002449 Walker A motif; other site 93061002450 ATP binding site [chemical binding]; other site 93061002451 Walker B motif; other site 93061002452 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 93061002453 Transcriptional regulator [Transcription]; Region: LysR; COG0583 93061002454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 93061002455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 93061002456 dimerization interface [polypeptide binding]; other site 93061002457 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 93061002458 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 93061002459 active site 93061002460 catalytic residues [active] 93061002461 metal binding site [ion binding]; metal-binding site 93061002462 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 93061002463 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 93061002464 substrate binding site [chemical binding]; other site 93061002465 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 93061002466 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 93061002467 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 93061002468 dimer interface [polypeptide binding]; other site 93061002469 active site 93061002470 CoA binding pocket [chemical binding]; other site 93061002471 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 93061002472 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 93061002473 dimer interface [polypeptide binding]; other site 93061002474 active site 93061002475 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 93061002476 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 93061002477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061002478 dimer interface [polypeptide binding]; other site 93061002479 conserved gate region; other site 93061002480 putative PBP binding loops; other site 93061002481 ABC-ATPase subunit interface; other site 93061002482 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 93061002483 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 93061002484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061002485 dimer interface [polypeptide binding]; other site 93061002486 conserved gate region; other site 93061002487 putative PBP binding loops; other site 93061002488 ABC-ATPase subunit interface; other site 93061002489 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 93061002490 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 93061002491 Walker A/P-loop; other site 93061002492 ATP binding site [chemical binding]; other site 93061002493 Q-loop/lid; other site 93061002494 ABC transporter signature motif; other site 93061002495 Walker B; other site 93061002496 D-loop; other site 93061002497 H-loop/switch region; other site 93061002498 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 93061002499 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 93061002500 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 93061002501 Walker A/P-loop; other site 93061002502 ATP binding site [chemical binding]; other site 93061002503 Q-loop/lid; other site 93061002504 ABC transporter signature motif; other site 93061002505 Walker B; other site 93061002506 D-loop; other site 93061002507 H-loop/switch region; other site 93061002508 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 93061002509 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 93061002510 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 93061002511 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 93061002512 peptide binding site [polypeptide binding]; other site 93061002513 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 93061002514 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 93061002515 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 93061002516 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 93061002517 Walker A/P-loop; other site 93061002518 ATP binding site [chemical binding]; other site 93061002519 Q-loop/lid; other site 93061002520 ABC transporter signature motif; other site 93061002521 Walker B; other site 93061002522 D-loop; other site 93061002523 H-loop/switch region; other site 93061002524 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 93061002525 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 93061002526 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 93061002527 Walker A/P-loop; other site 93061002528 ATP binding site [chemical binding]; other site 93061002529 Q-loop/lid; other site 93061002530 ABC transporter signature motif; other site 93061002531 Walker B; other site 93061002532 D-loop; other site 93061002533 H-loop/switch region; other site 93061002534 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 93061002535 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 93061002536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061002537 dimer interface [polypeptide binding]; other site 93061002538 conserved gate region; other site 93061002539 putative PBP binding loops; other site 93061002540 ABC-ATPase subunit interface; other site 93061002541 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 93061002542 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 93061002543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061002544 dimer interface [polypeptide binding]; other site 93061002545 conserved gate region; other site 93061002546 putative PBP binding loops; other site 93061002547 ABC-ATPase subunit interface; other site 93061002548 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 93061002549 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 93061002550 active site 93061002551 HIGH motif; other site 93061002552 dimer interface [polypeptide binding]; other site 93061002553 KMSKS motif; other site 93061002554 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 93061002555 putative catalytic residues [active] 93061002556 thiol/disulfide switch; other site 93061002557 adaptor protein; Provisional; Region: PRK02315 93061002558 Competence protein CoiA-like family; Region: CoiA; cl11541 93061002559 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 93061002560 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 93061002561 active site 93061002562 Zn binding site [ion binding]; other site 93061002563 Thioredoxin; Region: Thioredoxin_5; pfam13743 93061002564 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 93061002565 apolar tunnel; other site 93061002566 heme binding site [chemical binding]; other site 93061002567 dimerization interface [polypeptide binding]; other site 93061002568 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 93061002569 putative active site [active] 93061002570 putative metal binding residues [ion binding]; other site 93061002571 signature motif; other site 93061002572 putative triphosphate binding site [ion binding]; other site 93061002573 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 93061002574 synthetase active site [active] 93061002575 NTP binding site [chemical binding]; other site 93061002576 metal binding site [ion binding]; metal-binding site 93061002577 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 93061002578 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 93061002579 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 93061002580 active site 93061002581 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 93061002582 MgtE intracellular N domain; Region: MgtE_N; pfam03448 93061002583 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 93061002584 Divalent cation transporter; Region: MgtE; pfam01769 93061002585 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 93061002586 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 93061002587 TrkA-N domain; Region: TrkA_N; pfam02254 93061002588 TrkA-C domain; Region: TrkA_C; pfam02080 93061002589 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 93061002590 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 93061002591 NAD binding site [chemical binding]; other site 93061002592 homotetramer interface [polypeptide binding]; other site 93061002593 homodimer interface [polypeptide binding]; other site 93061002594 substrate binding site [chemical binding]; other site 93061002595 active site 93061002596 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 93061002597 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 93061002598 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 93061002599 Putative esterase; Region: Esterase; pfam00756 93061002600 hypothetical protein; Provisional; Region: PRK13679 93061002601 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 93061002602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061002603 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061002604 putative substrate translocation pore; other site 93061002605 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 93061002606 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 93061002607 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 93061002608 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 93061002609 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 93061002610 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 93061002611 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 93061002612 YueH-like protein; Region: YueH; pfam14166 93061002613 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 93061002614 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 93061002615 G1 box; other site 93061002616 putative GEF interaction site [polypeptide binding]; other site 93061002617 GTP/Mg2+ binding site [chemical binding]; other site 93061002618 Switch I region; other site 93061002619 G2 box; other site 93061002620 G3 box; other site 93061002621 Switch II region; other site 93061002622 G4 box; other site 93061002623 G5 box; other site 93061002624 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 93061002625 Elongation Factor G, domain II; Region: EFG_II; pfam14492 93061002626 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 93061002627 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 93061002628 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 93061002629 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 93061002630 protein binding site [polypeptide binding]; other site 93061002631 Cation transport protein; Region: TrkH; cl17365 93061002632 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 93061002633 Cation transport protein; Region: TrkH; cl17365 93061002634 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 93061002635 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 93061002636 active site 93061002637 metal binding site [ion binding]; metal-binding site 93061002638 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 93061002639 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 93061002640 IDEAL domain; Region: IDEAL; pfam08858 93061002641 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 93061002642 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 93061002643 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 93061002644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 93061002645 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 93061002646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 93061002647 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 93061002648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 93061002649 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061002650 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 93061002651 Walker A/P-loop; other site 93061002652 ATP binding site [chemical binding]; other site 93061002653 Q-loop/lid; other site 93061002654 ABC transporter signature motif; other site 93061002655 Walker B; other site 93061002656 D-loop; other site 93061002657 H-loop/switch region; other site 93061002658 Predicted membrane protein [Function unknown]; Region: COG2259 93061002659 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 93061002660 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 93061002661 siderophore binding site; other site 93061002662 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 93061002663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061002664 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 93061002665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 93061002666 Coenzyme A binding pocket [chemical binding]; other site 93061002667 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 93061002668 putative active site [active] 93061002669 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 93061002670 isochorismate synthases; Region: isochor_syn; TIGR00543 93061002671 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 93061002672 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 93061002673 dimer interface [polypeptide binding]; other site 93061002674 tetramer interface [polypeptide binding]; other site 93061002675 PYR/PP interface [polypeptide binding]; other site 93061002676 TPP binding site [chemical binding]; other site 93061002677 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 93061002678 TPP-binding site; other site 93061002679 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 93061002680 Putative lysophospholipase; Region: Hydrolase_4; cl19140 93061002681 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 93061002682 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 93061002683 substrate binding site [chemical binding]; other site 93061002684 oxyanion hole (OAH) forming residues; other site 93061002685 trimer interface [polypeptide binding]; other site 93061002686 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 93061002687 Staphostatin B; Region: Staphostatin_B; pfam09023 93061002688 Staphopain proregion; Region: Staphopain_pro; pfam14731 93061002689 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 93061002690 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 93061002691 aminotransferase A; Validated; Region: PRK07683 93061002692 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93061002693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061002694 homodimer interface [polypeptide binding]; other site 93061002695 catalytic residue [active] 93061002696 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 93061002697 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061002698 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 93061002699 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 93061002700 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 93061002701 amidase catalytic site [active] 93061002702 Zn binding residues [ion binding]; other site 93061002703 substrate binding site [chemical binding]; other site 93061002704 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 93061002705 Lysozyme subfamily 2; Region: LYZ2; smart00047 93061002706 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 93061002707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061002708 Coenzyme A binding pocket [chemical binding]; other site 93061002709 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 93061002710 Transcriptional regulator [Transcription]; Region: LytR; COG1316 93061002711 Beta-lactamase; Region: Beta-lactamase; pfam00144 93061002712 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 93061002713 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 93061002714 Subunit I/III interface [polypeptide binding]; other site 93061002715 Subunit III/IV interface [polypeptide binding]; other site 93061002716 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 93061002717 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 93061002718 D-pathway; other site 93061002719 Putative ubiquinol binding site [chemical binding]; other site 93061002720 Low-spin heme (heme b) binding site [chemical binding]; other site 93061002721 Putative water exit pathway; other site 93061002722 Binuclear center (heme o3/CuB) [ion binding]; other site 93061002723 K-pathway; other site 93061002724 Putative proton exit pathway; other site 93061002725 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 93061002726 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 93061002727 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 93061002728 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 93061002729 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 93061002730 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 93061002731 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 93061002732 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 93061002733 homodimer interface [polypeptide binding]; other site 93061002734 NADP binding site [chemical binding]; other site 93061002735 substrate binding site [chemical binding]; other site 93061002736 AIR carboxylase; Region: AIRC; cl00310 93061002737 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 93061002738 ATP-grasp domain; Region: ATP-grasp_4; cl17255 93061002739 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 93061002740 ATP binding site [chemical binding]; other site 93061002741 active site 93061002742 substrate binding site [chemical binding]; other site 93061002743 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 93061002744 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 93061002745 putative active site [active] 93061002746 catalytic triad [active] 93061002747 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 93061002748 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 93061002749 dimerization interface [polypeptide binding]; other site 93061002750 ATP binding site [chemical binding]; other site 93061002751 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 93061002752 dimerization interface [polypeptide binding]; other site 93061002753 ATP binding site [chemical binding]; other site 93061002754 amidophosphoribosyltransferase; Provisional; Region: PRK07272 93061002755 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 93061002756 active site 93061002757 tetramer interface [polypeptide binding]; other site 93061002758 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93061002759 active site 93061002760 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 93061002761 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 93061002762 dimerization interface [polypeptide binding]; other site 93061002763 putative ATP binding site [chemical binding]; other site 93061002764 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 93061002765 active site 93061002766 substrate binding site [chemical binding]; other site 93061002767 cosubstrate binding site; other site 93061002768 catalytic site [active] 93061002769 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 93061002770 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 93061002771 purine monophosphate binding site [chemical binding]; other site 93061002772 dimer interface [polypeptide binding]; other site 93061002773 putative catalytic residues [active] 93061002774 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 93061002775 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 93061002776 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 93061002777 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 93061002778 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 93061002779 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 93061002780 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 93061002781 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 93061002782 Walker A/P-loop; other site 93061002783 ATP binding site [chemical binding]; other site 93061002784 Q-loop/lid; other site 93061002785 ABC transporter signature motif; other site 93061002786 Walker B; other site 93061002787 D-loop; other site 93061002788 H-loop/switch region; other site 93061002789 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 93061002790 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 93061002791 Walker A/P-loop; other site 93061002792 ATP binding site [chemical binding]; other site 93061002793 Q-loop/lid; other site 93061002794 ABC transporter signature motif; other site 93061002795 Walker B; other site 93061002796 D-loop; other site 93061002797 H-loop/switch region; other site 93061002798 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 93061002799 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 93061002800 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 93061002801 putative RNA binding site [nucleotide binding]; other site 93061002802 Methyltransferase domain; Region: Methyltransf_26; pfam13659 93061002803 Domain of unknown function (DUF697); Region: DUF697; cl12064 93061002804 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 93061002805 dimerization domain swap beta strand [polypeptide binding]; other site 93061002806 regulatory protein interface [polypeptide binding]; other site 93061002807 active site 93061002808 regulatory phosphorylation site [posttranslational modification]; other site 93061002809 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 93061002810 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 93061002811 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 93061002812 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 93061002813 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 93061002814 catalytic residues [active] 93061002815 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 93061002816 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 93061002817 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 93061002818 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 93061002819 TrkA-N domain; Region: TrkA_N; pfam02254 93061002820 TrkA-C domain; Region: TrkA_C; pfam02080 93061002821 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 93061002822 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 93061002823 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 93061002824 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 93061002825 hypothetical protein; Provisional; Region: PRK13667 93061002826 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 93061002827 active site 93061002828 catalytic residues [active] 93061002829 metal binding site [ion binding]; metal-binding site 93061002830 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 93061002831 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 93061002832 TPP-binding site [chemical binding]; other site 93061002833 tetramer interface [polypeptide binding]; other site 93061002834 heterodimer interface [polypeptide binding]; other site 93061002835 phosphorylation loop region [posttranslational modification] 93061002836 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 93061002837 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 93061002838 alpha subunit interface [polypeptide binding]; other site 93061002839 TPP binding site [chemical binding]; other site 93061002840 heterodimer interface [polypeptide binding]; other site 93061002841 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 93061002842 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 93061002843 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 93061002844 E3 interaction surface; other site 93061002845 lipoyl attachment site [posttranslational modification]; other site 93061002846 e3 binding domain; Region: E3_binding; pfam02817 93061002847 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 93061002848 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 93061002849 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 93061002850 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93061002851 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 93061002852 hypothetical protein; Provisional; Region: PRK04387 93061002853 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 93061002854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93061002855 non-specific DNA binding site [nucleotide binding]; other site 93061002856 salt bridge; other site 93061002857 sequence-specific DNA binding site [nucleotide binding]; other site 93061002858 Cupin domain; Region: Cupin_2; pfam07883 93061002859 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 93061002860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061002861 Walker A/P-loop; other site 93061002862 ATP binding site [chemical binding]; other site 93061002863 Q-loop/lid; other site 93061002864 ABC transporter signature motif; other site 93061002865 Walker B; other site 93061002866 D-loop; other site 93061002867 H-loop/switch region; other site 93061002868 TOBE domain; Region: TOBE_2; pfam08402 93061002869 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 93061002870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061002871 dimer interface [polypeptide binding]; other site 93061002872 conserved gate region; other site 93061002873 putative PBP binding loops; other site 93061002874 ABC-ATPase subunit interface; other site 93061002875 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 93061002876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061002877 dimer interface [polypeptide binding]; other site 93061002878 conserved gate region; other site 93061002879 putative PBP binding loops; other site 93061002880 ABC-ATPase subunit interface; other site 93061002881 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 93061002882 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 93061002883 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 93061002884 manganese transport protein MntH; Reviewed; Region: PRK00701 93061002885 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 93061002886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 93061002887 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 93061002888 active site 93061002889 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 93061002890 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 93061002891 G1 box; other site 93061002892 putative GEF interaction site [polypeptide binding]; other site 93061002893 GTP/Mg2+ binding site [chemical binding]; other site 93061002894 Switch I region; other site 93061002895 G2 box; other site 93061002896 G3 box; other site 93061002897 Switch II region; other site 93061002898 G4 box; other site 93061002899 G5 box; other site 93061002900 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 93061002901 Elongation Factor G, domain II; Region: EFG_II; pfam14492 93061002902 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 93061002903 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 93061002904 hypothetical protein; Provisional; Region: PRK13666 93061002905 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 93061002906 pyruvate carboxylase; Reviewed; Region: PRK12999 93061002907 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 93061002908 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 93061002909 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 93061002910 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 93061002911 active site 93061002912 catalytic residues [active] 93061002913 metal binding site [ion binding]; metal-binding site 93061002914 homodimer binding site [polypeptide binding]; other site 93061002915 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 93061002916 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 93061002917 carboxyltransferase (CT) interaction site; other site 93061002918 biotinylation site [posttranslational modification]; other site 93061002919 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 93061002920 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 93061002921 putative active site [active] 93061002922 Predicted membrane protein [Function unknown]; Region: COG2322 93061002923 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 93061002924 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 93061002925 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 93061002926 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 93061002927 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 93061002928 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 93061002929 putative active site [active] 93061002930 catalytic site [active] 93061002931 putative metal binding site [ion binding]; other site 93061002932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 93061002933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061002934 S-adenosylmethionine binding site [chemical binding]; other site 93061002935 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 93061002936 active site 93061002937 (T/H)XGH motif; other site 93061002938 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 93061002939 hypothetical protein; Provisional; Region: PRK13670 93061002940 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 93061002941 heme uptake protein IsdB; Region: IsdB; TIGR03657 93061002942 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 93061002943 NEAr Transporter domain; Region: NEAT; smart00725 93061002944 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 93061002945 heme-binding site [chemical binding]; other site 93061002946 Protein of unknown function (DUF1675); Region: DUF1675; pfam07897 93061002947 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 93061002948 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 93061002949 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 93061002950 heme-binding site [chemical binding]; other site 93061002951 heme uptake protein IsdC; Region: IsdC; TIGR03656 93061002952 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 93061002953 heme-binding site [chemical binding]; other site 93061002954 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 93061002955 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 93061002956 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 93061002957 intersubunit interface [polypeptide binding]; other site 93061002958 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 93061002959 ABC-ATPase subunit interface; other site 93061002960 dimer interface [polypeptide binding]; other site 93061002961 putative PBP binding regions; other site 93061002962 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 93061002963 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 93061002964 active site 93061002965 catalytic site [active] 93061002966 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 93061002967 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 93061002968 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 93061002969 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 93061002970 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 93061002971 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 93061002972 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 93061002973 dimer interface [polypeptide binding]; other site 93061002974 motif 1; other site 93061002975 active site 93061002976 motif 2; other site 93061002977 motif 3; other site 93061002978 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 93061002979 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 93061002980 putative tRNA-binding site [nucleotide binding]; other site 93061002981 B3/4 domain; Region: B3_4; pfam03483 93061002982 tRNA synthetase B5 domain; Region: B5; smart00874 93061002983 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 93061002984 dimer interface [polypeptide binding]; other site 93061002985 motif 1; other site 93061002986 motif 3; other site 93061002987 motif 2; other site 93061002988 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 93061002989 ribonuclease HIII; Provisional; Region: PRK00996 93061002990 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 93061002991 Bacterial type 2 ribonuclease, HII and HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 93061002992 RNA/DNA hybrid binding site [nucleotide binding]; other site 93061002993 active site 93061002994 Cell division protein ZapA; Region: ZapA; cl01146 93061002995 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 93061002996 hypothetical protein; Provisional; Region: PRK08609 93061002997 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 93061002998 active site 93061002999 primer binding site [nucleotide binding]; other site 93061003000 NTP binding site [chemical binding]; other site 93061003001 metal binding triad [ion binding]; metal-binding site 93061003002 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 93061003003 active site 93061003004 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 93061003005 MutS domain III; Region: MutS_III; pfam05192 93061003006 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 93061003007 Walker A/P-loop; other site 93061003008 ATP binding site [chemical binding]; other site 93061003009 Q-loop/lid; other site 93061003010 ABC transporter signature motif; other site 93061003011 Walker B; other site 93061003012 D-loop; other site 93061003013 H-loop/switch region; other site 93061003014 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 93061003015 Smr domain; Region: Smr; pfam01713 93061003016 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 93061003017 catalytic residues [active] 93061003018 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 93061003019 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 93061003020 GIY-YIG motif/motif A; other site 93061003021 active site 93061003022 catalytic site [active] 93061003023 putative DNA binding site [nucleotide binding]; other site 93061003024 metal binding site [ion binding]; metal-binding site 93061003025 UvrB/uvrC motif; Region: UVR; pfam02151 93061003026 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 93061003027 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 93061003028 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 93061003029 putative Iron-sulfur protein interface [polypeptide binding]; other site 93061003030 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 93061003031 proximal heme binding site [chemical binding]; other site 93061003032 distal heme binding site [chemical binding]; other site 93061003033 putative dimer interface [polypeptide binding]; other site 93061003034 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 93061003035 L-aspartate oxidase; Provisional; Region: PRK06175 93061003036 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 93061003037 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 93061003038 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 93061003039 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 93061003040 glutamate racemase; Provisional; Region: PRK00865 93061003041 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 93061003042 active site 93061003043 dimerization interface [polypeptide binding]; other site 93061003044 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 93061003045 active site 93061003046 metal binding site [ion binding]; metal-binding site 93061003047 homotetramer interface [polypeptide binding]; other site 93061003048 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 93061003049 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 93061003050 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 93061003051 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 93061003052 beta-channel forming cytolysin; Region: hlyII; TIGR01002 93061003053 superantigen-like protein; Reviewed; Region: PRK13350 93061003054 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061003055 superantigen-like protein; Reviewed; Region: PRK13349 93061003056 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061003057 superantigen-like protein; Reviewed; Region: PRK13043 93061003058 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061003059 ornithine carbamoyltransferase; Provisional; Region: PRK04284 93061003060 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 93061003061 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 93061003062 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 93061003063 putative substrate binding site [chemical binding]; other site 93061003064 nucleotide binding site [chemical binding]; other site 93061003065 nucleotide binding site [chemical binding]; other site 93061003066 homodimer interface [polypeptide binding]; other site 93061003067 Predicted membrane protein [Function unknown]; Region: COG1288 93061003068 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 93061003069 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 93061003070 gating phenylalanine in ion channel; other site 93061003071 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 93061003072 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 93061003073 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 93061003074 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 93061003075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061003076 motif II; other site 93061003077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061003078 Coenzyme A binding pocket [chemical binding]; other site 93061003079 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 93061003080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 93061003081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 93061003082 MraZ protein; Region: MraZ; pfam02381 93061003083 MraZ protein; Region: MraZ; pfam02381 93061003084 MraW methylase family; Region: Methyltransf_5; pfam01795 93061003085 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 93061003086 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 93061003087 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 93061003088 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 93061003089 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 93061003090 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 93061003091 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 93061003092 Mg++ binding site [ion binding]; other site 93061003093 putative catalytic motif [active] 93061003094 putative substrate binding site [chemical binding]; other site 93061003095 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 93061003096 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 93061003097 NAD binding site [chemical binding]; other site 93061003098 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 93061003099 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 93061003100 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 93061003101 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 93061003102 Cell division protein FtsQ; Region: FtsQ; pfam03799 93061003103 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 93061003104 Cell division protein FtsA; Region: FtsA; smart00842 93061003105 Cell division protein FtsA; Region: FtsA; pfam14450 93061003106 cell division protein FtsZ; Validated; Region: PRK09330 93061003107 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 93061003108 nucleotide binding site [chemical binding]; other site 93061003109 SulA interaction site; other site 93061003110 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 93061003111 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 93061003112 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 93061003113 catalytic residue [active] 93061003114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 93061003115 Predicted integral membrane protein [Function unknown]; Region: COG0762 93061003116 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 93061003117 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93061003118 RNA binding surface [nucleotide binding]; other site 93061003119 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 93061003120 DivIVA protein; Region: DivIVA; pfam05103 93061003121 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 93061003122 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 93061003123 active site 93061003124 HIGH motif; other site 93061003125 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 93061003126 KMSKS motif; other site 93061003127 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 93061003128 tRNA binding surface [nucleotide binding]; other site 93061003129 anticodon binding site; other site 93061003130 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 93061003131 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 93061003132 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 93061003133 active site 93061003134 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 93061003135 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 93061003136 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93061003137 RNA binding surface [nucleotide binding]; other site 93061003138 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 93061003139 active site 93061003140 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93061003141 active site 93061003142 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 93061003143 Sulfate transporter family; Region: Sulfate_transp; cl19250 93061003144 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 93061003145 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 93061003146 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 93061003147 dihydroorotase; Validated; Region: pyrC; PRK09357 93061003148 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 93061003149 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 93061003150 active site 93061003151 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 93061003152 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 93061003153 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 93061003154 catalytic site [active] 93061003155 subunit interface [polypeptide binding]; other site 93061003156 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 93061003157 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 93061003158 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 93061003159 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 93061003160 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 93061003161 ATP-grasp domain; Region: ATP-grasp_4; cl17255 93061003162 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 93061003163 IMP binding site; other site 93061003164 dimer interface [polypeptide binding]; other site 93061003165 interdomain contacts; other site 93061003166 partial ornithine binding site; other site 93061003167 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 93061003168 active site 93061003169 dimer interface [polypeptide binding]; other site 93061003170 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93061003171 active site 93061003172 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 93061003173 dimer interface [polypeptide binding]; other site 93061003174 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 93061003175 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 93061003176 Domain of unknown function (DUF814); Region: DUF814; pfam05670 93061003177 Guanylate kinase; Region: Guanylate_kin; pfam00625 93061003178 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 93061003179 catalytic site [active] 93061003180 G-X2-G-X-G-K; other site 93061003181 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 93061003182 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 93061003183 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 93061003184 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 93061003185 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 93061003186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93061003187 ATP binding site [chemical binding]; other site 93061003188 putative Mg++ binding site [ion binding]; other site 93061003189 helicase superfamily c-terminal domain; Region: HELICc; smart00490 93061003190 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 93061003191 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 93061003192 active site 93061003193 catalytic residues [active] 93061003194 metal binding site [ion binding]; metal-binding site 93061003195 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 93061003196 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 93061003197 putative active site [active] 93061003198 substrate binding site [chemical binding]; other site 93061003199 putative cosubstrate binding site; other site 93061003200 catalytic site [active] 93061003201 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 93061003202 substrate binding site [chemical binding]; other site 93061003203 16S rRNA methyltransferase B; Provisional; Region: PRK14902 93061003204 NusB family; Region: NusB; pfam01029 93061003205 putative RNA binding site [nucleotide binding]; other site 93061003206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061003207 S-adenosylmethionine binding site [chemical binding]; other site 93061003208 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 93061003209 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 93061003210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93061003211 FeS/SAM binding site; other site 93061003212 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 93061003213 active site 93061003214 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 93061003215 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 93061003216 active site 93061003217 ATP binding site [chemical binding]; other site 93061003218 substrate binding site [chemical binding]; other site 93061003219 activation loop (A-loop); other site 93061003220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 93061003221 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 93061003222 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 93061003223 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 93061003224 Predicted GTPases [General function prediction only]; Region: COG1162 93061003225 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 93061003226 RNA binding site [nucleotide binding]; other site 93061003227 homodimer interface [polypeptide binding]; other site 93061003228 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 93061003229 GTPase/Zn-binding domain interface [polypeptide binding]; other site 93061003230 GTP/Mg2+ binding site [chemical binding]; other site 93061003231 G4 box; other site 93061003232 G5 box; other site 93061003233 G1 box; other site 93061003234 Switch I region; other site 93061003235 G2 box; other site 93061003236 G3 box; other site 93061003237 Switch II region; other site 93061003238 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 93061003239 substrate binding site [chemical binding]; other site 93061003240 hexamer interface [polypeptide binding]; other site 93061003241 metal binding site [ion binding]; metal-binding site 93061003242 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 93061003243 Thiamine pyrophosphokinase; Region: TPK; cd07995 93061003244 active site 93061003245 dimerization interface [polypeptide binding]; other site 93061003246 thiamine binding site [chemical binding]; other site 93061003247 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 93061003248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 93061003249 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 93061003250 DAK2 domain; Region: Dak2; pfam02734 93061003251 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 93061003252 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 93061003253 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 93061003254 generic binding surface II; other site 93061003255 ssDNA binding site; other site 93061003256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93061003257 ATP binding site [chemical binding]; other site 93061003258 putative Mg++ binding site [ion binding]; other site 93061003259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93061003260 nucleotide binding region [chemical binding]; other site 93061003261 ATP-binding site [chemical binding]; other site 93061003262 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 93061003263 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 93061003264 active site 2 [active] 93061003265 active site 1 [active] 93061003266 putative phosphate acyltransferase; Provisional; Region: PRK05331 93061003267 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 93061003268 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 93061003269 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 93061003270 NAD(P) binding site [chemical binding]; other site 93061003271 homotetramer interface [polypeptide binding]; other site 93061003272 homodimer interface [polypeptide binding]; other site 93061003273 active site 93061003274 acyl carrier protein; Provisional; Region: acpP; PRK00982 93061003275 ribonuclease III; Reviewed; Region: rnc; PRK00102 93061003276 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 93061003277 dimerization interface [polypeptide binding]; other site 93061003278 active site 93061003279 metal binding site [ion binding]; metal-binding site 93061003280 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 93061003281 dsRNA binding site [nucleotide binding]; other site 93061003282 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 93061003283 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 93061003284 Walker A/P-loop; other site 93061003285 ATP binding site [chemical binding]; other site 93061003286 Q-loop/lid; other site 93061003287 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 93061003288 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 93061003289 ABC transporter signature motif; other site 93061003290 Walker B; other site 93061003291 D-loop; other site 93061003292 H-loop/switch region; other site 93061003293 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 93061003294 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 93061003295 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 93061003296 P loop; other site 93061003297 GTP binding site [chemical binding]; other site 93061003298 putative DNA-binding protein; Validated; Region: PRK00118 93061003299 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 93061003300 signal recognition particle protein; Provisional; Region: PRK10867 93061003301 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 93061003302 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 93061003303 P loop; other site 93061003304 GTP binding site [chemical binding]; other site 93061003305 Signal peptide binding domain; Region: SRP_SPB; pfam02978 93061003306 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 93061003307 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 93061003308 RimM N-terminal domain; Region: RimM; pfam01782 93061003309 PRC-barrel domain; Region: PRC; pfam05239 93061003310 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 93061003311 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 93061003312 Predicted membrane protein [Function unknown]; Region: COG4485 93061003313 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 93061003314 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 93061003315 GTP/Mg2+ binding site [chemical binding]; other site 93061003316 G4 box; other site 93061003317 G5 box; other site 93061003318 G1 box; other site 93061003319 Switch I region; other site 93061003320 G2 box; other site 93061003321 G3 box; other site 93061003322 Switch II region; other site 93061003323 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 93061003324 RNA/DNA hybrid binding site [nucleotide binding]; other site 93061003325 active site 93061003326 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 93061003327 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 93061003328 CoA-ligase; Region: Ligase_CoA; pfam00549 93061003329 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 93061003330 CoA binding domain; Region: CoA_binding; pfam02629 93061003331 CoA-ligase; Region: Ligase_CoA; pfam00549 93061003332 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 93061003333 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93061003334 CHAP domain; Region: CHAP; pfam05257 93061003335 FemAB family; Region: FemAB; pfam02388 93061003336 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 93061003337 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 93061003338 DNA topoisomerase I; Validated; Region: PRK05582 93061003339 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 93061003340 active site 93061003341 interdomain interaction site; other site 93061003342 putative metal-binding site [ion binding]; other site 93061003343 nucleotide binding site [chemical binding]; other site 93061003344 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 93061003345 domain I; other site 93061003346 DNA binding groove [nucleotide binding] 93061003347 phosphate binding site [ion binding]; other site 93061003348 domain II; other site 93061003349 domain III; other site 93061003350 nucleotide binding site [chemical binding]; other site 93061003351 catalytic site [active] 93061003352 domain IV; other site 93061003353 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 93061003354 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 93061003355 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 93061003356 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 93061003357 Glucose inhibited division protein A; Region: GIDA; pfam01134 93061003358 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 93061003359 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 93061003360 active site 93061003361 DNA binding site [nucleotide binding] 93061003362 Int/Topo IB signature motif; other site 93061003363 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 93061003364 active site 93061003365 HslU subunit interaction site [polypeptide binding]; other site 93061003366 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 93061003367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061003368 Walker A motif; other site 93061003369 ATP binding site [chemical binding]; other site 93061003370 Walker B motif; other site 93061003371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061003372 Walker B motif; other site 93061003373 arginine finger; other site 93061003374 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 93061003375 transcriptional repressor CodY; Validated; Region: PRK04158 93061003376 CodY GAF-like domain; Region: CodY; pfam06018 93061003377 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 93061003378 elongation factor Ts; Provisional; Region: tsf; PRK09377 93061003379 UBA/TS-N domain; Region: UBA; pfam00627 93061003380 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 93061003381 putative nucleotide binding site [chemical binding]; other site 93061003382 uridine monophosphate binding site [chemical binding]; other site 93061003383 homohexameric interface [polypeptide binding]; other site 93061003384 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 93061003385 hinge region; other site 93061003386 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 93061003387 active site 93061003388 dimer interface [polypeptide binding]; other site 93061003389 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 93061003390 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 93061003391 RIP metalloprotease RseP; Region: TIGR00054 93061003392 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 93061003393 protein binding site [polypeptide binding]; other site 93061003394 putative substrate binding region [chemical binding]; other site 93061003395 prolyl-tRNA synthetase; Provisional; Region: PRK09194 93061003396 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 93061003397 dimer interface [polypeptide binding]; other site 93061003398 motif 1; other site 93061003399 active site 93061003400 motif 2; other site 93061003401 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 93061003402 putative deacylase active site [active] 93061003403 motif 3; other site 93061003404 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 93061003405 anticodon binding site; other site 93061003406 DNA polymerase III PolC; Validated; Region: polC; PRK00448 93061003407 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 93061003408 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 93061003409 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 93061003410 generic binding surface II; other site 93061003411 generic binding surface I; other site 93061003412 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 93061003413 active site 93061003414 putative PHP Thumb interface [polypeptide binding]; other site 93061003415 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 93061003416 active site 93061003417 catalytic site [active] 93061003418 substrate binding site [chemical binding]; other site 93061003419 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 93061003420 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 93061003421 Sm and related proteins; Region: Sm_like; cl00259 93061003422 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 93061003423 putative oligomer interface [polypeptide binding]; other site 93061003424 putative RNA binding site [nucleotide binding]; other site 93061003425 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 93061003426 NusA N-terminal domain; Region: NusA_N; pfam08529 93061003427 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 93061003428 RNA binding site [nucleotide binding]; other site 93061003429 homodimer interface [polypeptide binding]; other site 93061003430 NusA-like KH domain; Region: KH_5; pfam13184 93061003431 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 93061003432 G-X-X-G motif; other site 93061003433 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 93061003434 putative RNA binding cleft [nucleotide binding]; other site 93061003435 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 93061003436 translation initiation factor IF-2; Validated; Region: infB; PRK05306 93061003437 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 93061003438 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 93061003439 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 93061003440 G1 box; other site 93061003441 putative GEF interaction site [polypeptide binding]; other site 93061003442 GTP/Mg2+ binding site [chemical binding]; other site 93061003443 Switch I region; other site 93061003444 G2 box; other site 93061003445 G3 box; other site 93061003446 Switch II region; other site 93061003447 G4 box; other site 93061003448 G5 box; other site 93061003449 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 93061003450 Translation-initiation factor 2; Region: IF-2; pfam11987 93061003451 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 93061003452 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 93061003453 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 93061003454 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 93061003455 RNA binding site [nucleotide binding]; other site 93061003456 active site 93061003457 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 93061003458 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 93061003459 active site 93061003460 Riboflavin kinase; Region: Flavokinase; smart00904 93061003461 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 93061003462 16S/18S rRNA binding site [nucleotide binding]; other site 93061003463 S13e-L30e interaction site [polypeptide binding]; other site 93061003464 25S rRNA binding site [nucleotide binding]; other site 93061003465 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 93061003466 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 93061003467 RNase E interface [polypeptide binding]; other site 93061003468 trimer interface [polypeptide binding]; other site 93061003469 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 93061003470 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 93061003471 RNase E interface [polypeptide binding]; other site 93061003472 trimer interface [polypeptide binding]; other site 93061003473 active site 93061003474 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 93061003475 putative nucleic acid binding region [nucleotide binding]; other site 93061003476 G-X-X-G motif; other site 93061003477 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 93061003478 RNA binding site [nucleotide binding]; other site 93061003479 domain interface; other site 93061003480 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 93061003481 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 93061003482 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 93061003483 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 93061003484 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 93061003485 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 93061003486 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 93061003487 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 93061003488 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 93061003489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 93061003490 DNA-binding site [nucleotide binding]; DNA binding site 93061003491 UTRA domain; Region: UTRA; pfam07702 93061003492 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 93061003493 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 93061003494 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 93061003495 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 93061003496 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 93061003497 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 93061003498 classical (c) SDRs; Region: SDR_c; cd05233 93061003499 NAD(P) binding site [chemical binding]; other site 93061003500 active site 93061003501 ACT domain; Region: ACT; pfam01842 93061003502 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 93061003503 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 93061003504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93061003505 non-specific DNA binding site [nucleotide binding]; other site 93061003506 salt bridge; other site 93061003507 sequence-specific DNA binding site [nucleotide binding]; other site 93061003508 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 93061003509 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 93061003510 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 93061003511 putative MPT binding site; other site 93061003512 recombinase A; Provisional; Region: recA; PRK09354 93061003513 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 93061003514 hexamer interface [polypeptide binding]; other site 93061003515 Walker A motif; other site 93061003516 ATP binding site [chemical binding]; other site 93061003517 Walker B motif; other site 93061003518 ribonuclease Y; Region: RNase_Y; TIGR03319 93061003519 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 93061003520 She9 / Mdm33 family; Region: She9_MDM33; pfam05546 93061003521 KH domain; Region: KH_1; pfam00013 93061003522 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 93061003523 Zn2+ binding site [ion binding]; other site 93061003524 Mg2+ binding site [ion binding]; other site 93061003525 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 93061003526 putative active site [active] 93061003527 metal binding site [ion binding]; metal-binding site 93061003528 homodimer binding site [polypeptide binding]; other site 93061003529 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 93061003530 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 93061003531 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 93061003532 dimer interface [polypeptide binding]; other site 93061003533 PYR/PP interface [polypeptide binding]; other site 93061003534 TPP binding site [chemical binding]; other site 93061003535 substrate binding site [chemical binding]; other site 93061003536 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 93061003537 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 93061003538 TPP-binding site [chemical binding]; other site 93061003539 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 93061003540 Uncharacterized conserved protein [Function unknown]; Region: COG0011 93061003541 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 93061003542 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 93061003543 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93061003544 FeS/SAM binding site; other site 93061003545 TRAM domain; Region: TRAM; pfam01938 93061003546 Predicted membrane protein [Function unknown]; Region: COG4550 93061003547 Predicted membrane protein [Function unknown]; Region: COG4732 93061003548 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 93061003549 MutS domain I; Region: MutS_I; pfam01624 93061003550 MutS domain II; Region: MutS_II; pfam05188 93061003551 MutS domain III; Region: MutS_III; pfam05192 93061003552 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 93061003553 Walker A/P-loop; other site 93061003554 ATP binding site [chemical binding]; other site 93061003555 Q-loop/lid; other site 93061003556 ABC transporter signature motif; other site 93061003557 Walker B; other site 93061003558 D-loop; other site 93061003559 H-loop/switch region; other site 93061003560 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 93061003561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061003562 ATP binding site [chemical binding]; other site 93061003563 Mg2+ binding site [ion binding]; other site 93061003564 G-X-G motif; other site 93061003565 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 93061003566 ATP binding site [chemical binding]; other site 93061003567 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 93061003568 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 93061003569 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 93061003570 amphipathic channel; other site 93061003571 Asn-Pro-Ala signature motifs; other site 93061003572 glycerol kinase; Provisional; Region: glpK; PRK00047 93061003573 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 93061003574 N- and C-terminal domain interface [polypeptide binding]; other site 93061003575 active site 93061003576 MgATP binding site [chemical binding]; other site 93061003577 catalytic site [active] 93061003578 metal binding site [ion binding]; metal-binding site 93061003579 glycerol binding site [chemical binding]; other site 93061003580 homotetramer interface [polypeptide binding]; other site 93061003581 homodimer interface [polypeptide binding]; other site 93061003582 FBP binding site [chemical binding]; other site 93061003583 protein IIAGlc interface [polypeptide binding]; other site 93061003584 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 93061003585 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 93061003586 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 93061003587 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 93061003588 PGAP1-like protein; Region: PGAP1; pfam07819 93061003589 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 93061003590 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 93061003591 bacterial Hfq-like; Region: Hfq; cd01716 93061003592 hexamer interface [polypeptide binding]; other site 93061003593 Sm1 motif; other site 93061003594 RNA binding site [nucleotide binding]; other site 93061003595 Sm2 motif; other site 93061003596 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 93061003597 catalytic residues [active] 93061003598 dimer interface [polypeptide binding]; other site 93061003599 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 93061003600 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 93061003601 HflX GTPase family; Region: HflX; cd01878 93061003602 G1 box; other site 93061003603 GTP/Mg2+ binding site [chemical binding]; other site 93061003604 Switch I region; other site 93061003605 G2 box; other site 93061003606 G3 box; other site 93061003607 Switch II region; other site 93061003608 G4 box; other site 93061003609 G5 box; other site 93061003610 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 93061003611 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 93061003612 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 93061003613 DNA binding residues [nucleotide binding] 93061003614 putative dimer interface [polypeptide binding]; other site 93061003615 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 93061003616 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 93061003617 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 93061003618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 93061003619 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 93061003620 Pathogenicity factor; Region: AvrE; pfam11725 93061003621 Putative toxin 64; Region: Toxin_64; pfam15542 93061003622 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 93061003623 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 93061003624 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93061003625 catalytic residue [active] 93061003626 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 93061003627 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 93061003628 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 93061003629 putative active site [active] 93061003630 catalytic site [active] 93061003631 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 93061003632 putative active site [active] 93061003633 catalytic site [active] 93061003634 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 93061003635 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 93061003636 Walker A/P-loop; other site 93061003637 ATP binding site [chemical binding]; other site 93061003638 Q-loop/lid; other site 93061003639 ABC transporter signature motif; other site 93061003640 Walker B; other site 93061003641 D-loop; other site 93061003642 H-loop/switch region; other site 93061003643 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 93061003644 Acyltransferase family; Region: Acyl_transf_3; cl19154 93061003645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 93061003646 Histidine kinase; Region: HisKA_3; pfam07730 93061003647 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 93061003648 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 93061003649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061003650 active site 93061003651 phosphorylation site [posttranslational modification] 93061003652 intermolecular recognition site; other site 93061003653 dimerization interface [polypeptide binding]; other site 93061003654 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 93061003655 DNA binding residues [nucleotide binding] 93061003656 dimerization interface [polypeptide binding]; other site 93061003657 Staphylococcal nuclease homologues; Region: SNc; smart00318 93061003658 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 93061003659 Catalytic site; other site 93061003660 AAA domain; Region: AAA_11; pfam13086 93061003661 aspartate kinase; Reviewed; Region: PRK09034 93061003662 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 93061003663 putative catalytic residues [active] 93061003664 putative nucleotide binding site [chemical binding]; other site 93061003665 putative aspartate binding site [chemical binding]; other site 93061003666 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 93061003667 allosteric regulatory residue; other site 93061003668 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 93061003669 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 93061003670 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 93061003671 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 93061003672 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 93061003673 homodimer interface [polypeptide binding]; other site 93061003674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061003675 catalytic residue [active] 93061003676 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 93061003677 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 93061003678 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 93061003679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061003680 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 93061003681 active site 93061003682 motif I; other site 93061003683 motif II; other site 93061003684 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 93061003685 lysine transporter; Provisional; Region: PRK10836 93061003686 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 93061003687 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 93061003688 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 93061003689 tetramer interface [polypeptide binding]; other site 93061003690 heme binding pocket [chemical binding]; other site 93061003691 NADPH binding site [chemical binding]; other site 93061003692 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 93061003693 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 93061003694 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 93061003695 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 93061003696 active site 93061003697 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 93061003698 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 93061003699 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 93061003700 LexA repressor; Validated; Region: PRK00215 93061003701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 93061003702 putative DNA binding site [nucleotide binding]; other site 93061003703 putative Zn2+ binding site [ion binding]; other site 93061003704 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 93061003705 Catalytic site [active] 93061003706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 93061003707 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 93061003708 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 93061003709 TPP-binding site [chemical binding]; other site 93061003710 dimer interface [polypeptide binding]; other site 93061003711 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 93061003712 PYR/PP interface [polypeptide binding]; other site 93061003713 dimer interface [polypeptide binding]; other site 93061003714 TPP binding site [chemical binding]; other site 93061003715 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 93061003716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 93061003717 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 93061003718 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 93061003719 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 93061003720 active site 93061003721 metal binding site [ion binding]; metal-binding site 93061003722 DNA binding site [nucleotide binding] 93061003723 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 93061003724 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 93061003725 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 93061003726 aconitate hydratase; Validated; Region: PRK09277 93061003727 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 93061003728 substrate binding site [chemical binding]; other site 93061003729 ligand binding site [chemical binding]; other site 93061003730 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 93061003731 substrate binding site [chemical binding]; other site 93061003732 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 93061003733 active site 93061003734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 93061003735 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 93061003736 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 93061003737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061003738 ATP binding site [chemical binding]; other site 93061003739 Mg2+ binding site [ion binding]; other site 93061003740 G-X-G motif; other site 93061003741 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 93061003742 anchoring element; other site 93061003743 dimer interface [polypeptide binding]; other site 93061003744 ATP binding site [chemical binding]; other site 93061003745 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 93061003746 active site 93061003747 metal binding site [ion binding]; metal-binding site 93061003748 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 93061003749 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 93061003750 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 93061003751 CAP-like domain; other site 93061003752 active site 93061003753 primary dimer interface [polypeptide binding]; other site 93061003754 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93061003755 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 93061003756 CAT RNA binding domain; Region: CAT_RBD; cl03904 93061003757 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 93061003758 PRD domain; Region: PRD; pfam00874 93061003759 PRD domain; Region: PRD; pfam00874 93061003760 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 93061003761 Predicted integral membrane protein [Function unknown]; Region: COG0392 93061003762 Uncharacterized conserved protein [Function unknown]; Region: COG2898 93061003763 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 93061003764 methionine sulfoxide reductase A; Provisional; Region: PRK14054 93061003765 Transcriptional regulator [Transcription]; Region: LytR; COG1316 93061003766 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 93061003767 active site 1 [active] 93061003768 dimer interface [polypeptide binding]; other site 93061003769 hexamer interface [polypeptide binding]; other site 93061003770 active site 2 [active] 93061003771 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 93061003772 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 93061003773 active site 93061003774 DNA binding site [nucleotide binding] 93061003775 prephenate dehydrogenase; Validated; Region: PRK06545 93061003776 prephenate dehydrogenase; Validated; Region: PRK08507 93061003777 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 93061003778 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 93061003779 putative oligomer interface [polypeptide binding]; other site 93061003780 putative active site [active] 93061003781 metal binding site [ion binding]; metal-binding site 93061003782 anthranilate synthase component I; Provisional; Region: PRK13567 93061003783 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 93061003784 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 93061003785 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 93061003786 Glutamine amidotransferase class-I; Region: GATase; pfam00117 93061003787 glutamine binding [chemical binding]; other site 93061003788 catalytic triad [active] 93061003789 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 93061003790 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 93061003791 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 93061003792 active site 93061003793 ribulose/triose binding site [chemical binding]; other site 93061003794 phosphate binding site [ion binding]; other site 93061003795 substrate (anthranilate) binding pocket [chemical binding]; other site 93061003796 product (indole) binding pocket [chemical binding]; other site 93061003797 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 93061003798 active site 93061003799 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 93061003800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061003801 catalytic residue [active] 93061003802 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 93061003803 substrate binding site [chemical binding]; other site 93061003804 active site 93061003805 catalytic residues [active] 93061003806 heterodimer interface [polypeptide binding]; other site 93061003807 FemAB family; Region: FemAB; pfam02388 93061003808 FemAB family; Region: FemAB; pfam02388 93061003809 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 93061003810 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061003811 active site 93061003812 motif I; other site 93061003813 motif II; other site 93061003814 SWIM zinc finger; Region: SWIM; pfam04434 93061003815 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 93061003816 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 93061003817 Walker A/P-loop; other site 93061003818 ATP binding site [chemical binding]; other site 93061003819 Q-loop/lid; other site 93061003820 ABC transporter signature motif; other site 93061003821 Walker B; other site 93061003822 D-loop; other site 93061003823 H-loop/switch region; other site 93061003824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061003825 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 93061003826 Walker A/P-loop; other site 93061003827 ATP binding site [chemical binding]; other site 93061003828 Q-loop/lid; other site 93061003829 ABC transporter signature motif; other site 93061003830 Walker B; other site 93061003831 D-loop; other site 93061003832 H-loop/switch region; other site 93061003833 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 93061003834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061003835 dimer interface [polypeptide binding]; other site 93061003836 conserved gate region; other site 93061003837 putative PBP binding loops; other site 93061003838 ABC-ATPase subunit interface; other site 93061003839 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 93061003840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061003841 dimer interface [polypeptide binding]; other site 93061003842 conserved gate region; other site 93061003843 putative PBP binding loops; other site 93061003844 ABC-ATPase subunit interface; other site 93061003845 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 93061003846 oligoendopeptidase F; Region: pepF; TIGR00181 93061003847 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 93061003848 active site 93061003849 Zn binding site [ion binding]; other site 93061003850 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 93061003851 PhoU domain; Region: PhoU; pfam01895 93061003852 PhoU domain; Region: PhoU; pfam01895 93061003853 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 93061003854 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 93061003855 Walker A/P-loop; other site 93061003856 ATP binding site [chemical binding]; other site 93061003857 Q-loop/lid; other site 93061003858 ABC transporter signature motif; other site 93061003859 Walker B; other site 93061003860 D-loop; other site 93061003861 H-loop/switch region; other site 93061003862 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 93061003863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061003864 dimer interface [polypeptide binding]; other site 93061003865 conserved gate region; other site 93061003866 putative PBP binding loops; other site 93061003867 ABC-ATPase subunit interface; other site 93061003868 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 93061003869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061003870 dimer interface [polypeptide binding]; other site 93061003871 conserved gate region; other site 93061003872 putative PBP binding loops; other site 93061003873 ABC-ATPase subunit interface; other site 93061003874 phosphate binding protein; Region: ptsS_2; TIGR02136 93061003875 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 93061003876 S1 domain; Region: S1_2; pfam13509 93061003877 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 93061003878 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 93061003879 ABC transporter; Region: ABC_tran_2; pfam12848 93061003880 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 93061003881 aspartate kinase; Reviewed; Region: PRK06635 93061003882 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 93061003883 putative nucleotide binding site [chemical binding]; other site 93061003884 putative catalytic residues [active] 93061003885 putative Mg ion binding site [ion binding]; other site 93061003886 putative aspartate binding site [chemical binding]; other site 93061003887 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 93061003888 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 93061003889 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 93061003890 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 93061003891 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 93061003892 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 93061003893 dimer interface [polypeptide binding]; other site 93061003894 active site 93061003895 catalytic residue [active] 93061003896 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 93061003897 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 93061003898 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 93061003899 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 93061003900 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 93061003901 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 93061003902 trimer interface [polypeptide binding]; other site 93061003903 active site 93061003904 substrate binding site [chemical binding]; other site 93061003905 CoA binding site [chemical binding]; other site 93061003906 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 93061003907 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 93061003908 metal binding site [ion binding]; metal-binding site 93061003909 dimer interface [polypeptide binding]; other site 93061003910 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 93061003911 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 93061003912 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 93061003913 catalytic residue [active] 93061003914 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 93061003915 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 93061003916 active site 93061003917 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 93061003918 substrate binding site [chemical binding]; other site 93061003919 catalytic residues [active] 93061003920 dimer interface [polypeptide binding]; other site 93061003921 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 93061003922 DNA-binding site [nucleotide binding]; DNA binding site 93061003923 RNA-binding motif; other site 93061003924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 93061003925 acylphosphatase; Provisional; Region: PRK14431 93061003926 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 93061003927 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 93061003928 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 93061003929 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 93061003930 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 93061003931 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 93061003932 metal ion-dependent adhesion site (MIDAS); other site 93061003933 MoxR-like ATPases [General function prediction only]; Region: COG0714 93061003934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061003935 Walker A motif; other site 93061003936 ATP binding site [chemical binding]; other site 93061003937 Walker B motif; other site 93061003938 arginine finger; other site 93061003939 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 93061003940 active site 93061003941 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 93061003942 active site 93061003943 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 93061003944 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 93061003945 E3 interaction surface; other site 93061003946 lipoyl attachment site [posttranslational modification]; other site 93061003947 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 93061003948 G4 box; other site 93061003949 e3 binding domain; Region: E3_binding; pfam02817 93061003950 G5 box; other site 93061003951 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 93061003952 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 93061003953 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 93061003954 TPP-binding site [chemical binding]; other site 93061003955 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 93061003956 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 93061003957 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 93061003958 HAMP domain; Region: HAMP; pfam00672 93061003959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 93061003960 dimer interface [polypeptide binding]; other site 93061003961 phosphorylation site [posttranslational modification] 93061003962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061003963 ATP binding site [chemical binding]; other site 93061003964 Mg2+ binding site [ion binding]; other site 93061003965 G-X-G motif; other site 93061003966 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 93061003967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061003968 active site 93061003969 phosphorylation site [posttranslational modification] 93061003970 intermolecular recognition site; other site 93061003971 dimerization interface [polypeptide binding]; other site 93061003972 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93061003973 DNA binding site [nucleotide binding] 93061003974 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 93061003975 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 93061003976 active site 93061003977 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 93061003978 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 93061003979 active site 93061003980 homodimer interface [polypeptide binding]; other site 93061003981 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 93061003982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061003983 Coenzyme A binding pocket [chemical binding]; other site 93061003984 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 93061003985 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 93061003986 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 93061003987 protein binding site [polypeptide binding]; other site 93061003988 Catalytic dyad [active] 93061003989 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 93061003990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 93061003991 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 93061003992 HPr interaction site; other site 93061003993 glycerol kinase (GK) interaction site [polypeptide binding]; other site 93061003994 active site 93061003995 phosphorylation site [posttranslational modification] 93061003996 methionine sulfoxide reductase B; Provisional; Region: PRK00222 93061003997 methionine sulfoxide reductase A; Provisional; Region: PRK13014 93061003998 EDD domain protein, DegV family; Region: DegV; TIGR00762 93061003999 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 93061004000 folate binding site [chemical binding]; other site 93061004001 NADP+ binding site [chemical binding]; other site 93061004002 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 93061004003 dimerization interface [polypeptide binding]; other site 93061004004 active site 93061004005 Disulphide isomerase; Region: Disulph_isomer; pfam06491 93061004006 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 93061004007 Virulence factor; Region: Virulence_fact; pfam13769 93061004008 HEAT repeats; Region: HEAT_2; pfam13646 93061004009 HEAT repeat; Region: HEAT; pfam02985 93061004010 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 93061004011 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 93061004012 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 93061004013 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 93061004014 RNA/DNA hybrid binding site [nucleotide binding]; other site 93061004015 active site 93061004016 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 93061004017 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 93061004018 Predicted membrane protein [Function unknown]; Region: COG1511 93061004019 GA module; Region: GA; smart00844 93061004020 GA module; Region: GA; smart00844 93061004021 GA module; Region: GA; smart00844 93061004022 GA module; Region: GA; smart00844 93061004023 GA module; Region: GA; smart00844 93061004024 GA module; Region: GA; smart00844 93061004025 GA module; Region: GA; smart00844 93061004026 GA module; Region: GA; smart00844 93061004027 GA module; Region: GA; smart00844 93061004028 GA module; Region: GA; smart00844 93061004029 GA module; Region: GA; smart00844 93061004030 GA module; Region: GA; smart00844 93061004031 GA module; Region: GA; smart00844 93061004032 GA module; Region: GA; smart00844 93061004033 GA module; Region: GA; smart00844 93061004034 GA module; Region: GA; smart00844 93061004035 GA module; Region: GA; smart00844 93061004036 GA module; Region: GA; smart00844 93061004037 GA module; Region: GA; smart00844 93061004038 GA module; Region: GA; smart00844 93061004039 GA module; Region: GA; smart00844 93061004040 GA module; Region: GA; smart00844 93061004041 GA module; Region: GA; smart00844 93061004042 GA module; Region: GA; pfam01468 93061004043 GA module; Region: GA; smart00844 93061004044 GA module; Region: GA; smart00844 93061004045 GA module; Region: GA; smart00844 93061004046 GA module; Region: GA; smart00844 93061004047 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 93061004048 GA module; Region: GA; smart00844 93061004049 GA module; Region: GA; smart00844 93061004050 GA module; Region: GA; smart00844 93061004051 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 93061004052 GA module; Region: GA; smart00844 93061004053 GA module; Region: GA; smart00844 93061004054 GA module; Region: GA; smart00844 93061004055 GA module; Region: GA; smart00844 93061004056 GA module; Region: GA; smart00844 93061004057 GA module; Region: GA; smart00844 93061004058 GA module; Region: GA; smart00844 93061004059 GA module; Region: GA; smart00844 93061004060 GA module; Region: GA; smart00844 93061004061 GA module; Region: GA; smart00844 93061004062 GA module; Region: GA; smart00844 93061004063 GA module; Region: GA; smart00844 93061004064 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061004065 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061004066 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061004067 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061004068 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061004069 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061004070 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061004071 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061004072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061004073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061004074 putative substrate translocation pore; other site 93061004075 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 93061004076 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 93061004077 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 93061004078 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 93061004079 tetramer interface [polypeptide binding]; other site 93061004080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061004081 catalytic residue [active] 93061004082 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 93061004083 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 93061004084 hexamer interface [polypeptide binding]; other site 93061004085 ligand binding site [chemical binding]; other site 93061004086 putative active site [active] 93061004087 NAD(P) binding site [chemical binding]; other site 93061004088 5'-3' exonuclease; Region: 53EXOc; smart00475 93061004089 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 93061004090 active site 93061004091 metal binding site 1 [ion binding]; metal-binding site 93061004092 putative 5' ssDNA interaction site; other site 93061004093 metal binding site 3; metal-binding site 93061004094 metal binding site 2 [ion binding]; metal-binding site 93061004095 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 93061004096 putative DNA binding site [nucleotide binding]; other site 93061004097 putative metal binding site [ion binding]; other site 93061004098 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 93061004099 G1 box; other site 93061004100 GTP/Mg2+ binding site [chemical binding]; other site 93061004101 G2 box; other site 93061004102 Switch I region; other site 93061004103 G3 box; other site 93061004104 Switch II region; other site 93061004105 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 93061004106 G4 box; other site 93061004107 Dynamin family; Region: Dynamin_N; pfam00350 93061004108 G1 box; other site 93061004109 GTP/Mg2+ binding site [chemical binding]; other site 93061004110 G2 box; other site 93061004111 Switch I region; other site 93061004112 G3 box; other site 93061004113 Switch II region; other site 93061004114 G4 box; other site 93061004115 G5 box; other site 93061004116 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 93061004117 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 93061004118 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 93061004119 Cobalt transport protein component CbiN; Region: CbiN; cl00842 93061004120 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 93061004121 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 93061004122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 93061004123 cell division protein GpsB; Provisional; Region: PRK14127; cl19517 93061004124 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 93061004125 hypothetical protein; Provisional; Region: PRK13660 93061004126 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 93061004127 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 93061004128 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 93061004129 Transglycosylase; Region: Transgly; pfam00912 93061004130 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 93061004131 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 93061004132 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 93061004133 minor groove reading motif; other site 93061004134 helix-hairpin-helix signature motif; other site 93061004135 substrate binding pocket [chemical binding]; other site 93061004136 active site 93061004137 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 93061004138 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 93061004139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 93061004140 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 93061004141 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 93061004142 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 93061004143 putative dimer interface [polypeptide binding]; other site 93061004144 putative anticodon binding site; other site 93061004145 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 93061004146 homodimer interface [polypeptide binding]; other site 93061004147 motif 1; other site 93061004148 motif 2; other site 93061004149 active site 93061004150 motif 3; other site 93061004151 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 93061004152 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 93061004153 active site 93061004154 catalytic site [active] 93061004155 substrate binding site [chemical binding]; other site 93061004156 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 93061004157 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 93061004158 Biotin operon repressor [Transcription]; Region: BirA; COG1654 93061004159 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 93061004160 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 93061004161 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 93061004162 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 93061004163 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 93061004164 active site 93061004165 NTP binding site [chemical binding]; other site 93061004166 metal binding triad [ion binding]; metal-binding site 93061004167 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 93061004168 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 93061004169 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 93061004170 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 93061004171 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 93061004172 homodimer interface [polypeptide binding]; other site 93061004173 metal binding site [ion binding]; metal-binding site 93061004174 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 93061004175 Predicted membrane protein [Function unknown]; Region: COG4347 93061004176 Uncharacterized conserved protein [Function unknown]; Region: COG5582 93061004177 UPF0302 domain; Region: UPF0302; pfam08864 93061004178 IDEAL domain; Region: IDEAL; pfam08858 93061004179 TPR repeat; Region: TPR_11; pfam13414 93061004180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93061004181 binding surface 93061004182 TPR motif; other site 93061004183 Tetratricopeptide repeat; Region: TPR_12; pfam13424 93061004184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93061004185 TPR motif; other site 93061004186 binding surface 93061004187 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 93061004188 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 93061004189 hinge; other site 93061004190 active site 93061004191 Dehydroquinate synthase-like which includes dehydroquinate synthase, 2-deoxy-scyllo-inosose synthase, and 2-epi-5-epi-valiolone synthase; Region: DHQ-like; cd08169 93061004192 active site 93061004193 dimer interface [polypeptide binding]; other site 93061004194 metal binding site [ion binding]; metal-binding site 93061004195 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 93061004196 Tetramer interface [polypeptide binding]; other site 93061004197 active site 93061004198 FMN-binding site [chemical binding]; other site 93061004199 Nucleoside diphosphate kinase; Region: NDK; pfam00334 93061004200 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 93061004201 active site 93061004202 multimer interface [polypeptide binding]; other site 93061004203 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 93061004204 substrate binding pocket [chemical binding]; other site 93061004205 chain length determination region; other site 93061004206 substrate-Mg2+ binding site; other site 93061004207 catalytic residues [active] 93061004208 aspartate-rich region 1; other site 93061004209 active site lid residues [active] 93061004210 aspartate-rich region 2; other site 93061004211 Methyltransferase domain; Region: Methyltransf_31; pfam13847 93061004212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061004213 S-adenosylmethionine binding site [chemical binding]; other site 93061004214 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 93061004215 histone-like DNA-binding protein HU; Region: HU; cd13831 93061004216 dimer interface [polypeptide binding]; other site 93061004217 DNA binding site [nucleotide binding] 93061004218 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 93061004219 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 93061004220 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 93061004221 GTP-binding protein Der; Reviewed; Region: PRK00093 93061004222 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 93061004223 G1 box; other site 93061004224 GTP/Mg2+ binding site [chemical binding]; other site 93061004225 Switch I region; other site 93061004226 G2 box; other site 93061004227 Switch II region; other site 93061004228 G3 box; other site 93061004229 G4 box; other site 93061004230 G5 box; other site 93061004231 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 93061004232 G1 box; other site 93061004233 GTP/Mg2+ binding site [chemical binding]; other site 93061004234 Switch I region; other site 93061004235 G2 box; other site 93061004236 G3 box; other site 93061004237 Switch II region; other site 93061004238 G4 box; other site 93061004239 G5 box; other site 93061004240 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 93061004241 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 93061004242 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 93061004243 RNA binding site [nucleotide binding]; other site 93061004244 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 93061004245 RNA binding site [nucleotide binding]; other site 93061004246 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 93061004247 RNA binding site [nucleotide binding]; other site 93061004248 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 93061004249 RNA binding site [nucleotide binding]; other site 93061004250 cytidylate kinase; Provisional; Region: cmk; PRK00023 93061004251 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 93061004252 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 93061004253 active site 93061004254 CMP-binding site; other site 93061004255 The sites determining sugar specificity; other site 93061004256 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 93061004257 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 93061004258 active site 93061004259 homotetramer interface [polypeptide binding]; other site 93061004260 homodimer interface [polypeptide binding]; other site 93061004261 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 93061004262 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 93061004263 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93061004264 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93061004265 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 93061004266 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93061004267 ATP binding site [chemical binding]; other site 93061004268 putative Mg++ binding site [ion binding]; other site 93061004269 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93061004270 nucleotide binding region [chemical binding]; other site 93061004271 ATP-binding site [chemical binding]; other site 93061004272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 93061004273 Helix-turn-helix domain; Region: HTH_40; pfam14493 93061004274 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 93061004275 Predicted membrane protein [Function unknown]; Region: COG3601 93061004276 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 93061004277 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 93061004278 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 93061004279 Predicted integral membrane protein [Function unknown]; Region: COG5617 93061004280 CHAP domain; Region: CHAP; pfam05257 93061004281 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 93061004282 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 93061004283 active site 93061004284 metal binding site [ion binding]; metal-binding site 93061004285 Bacterial SH3 domain homologues; Region: SH3b; smart00287 93061004286 holin, SPP1 family; Region: holin_SPP1; TIGR01592 93061004287 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 93061004288 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 93061004289 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 93061004290 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 93061004291 hypothetical protein; Provisional; Region: PRK05926 93061004292 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 93061004293 Phage tail protein; Region: Sipho_tail; pfam05709 93061004294 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 93061004295 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 93061004296 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 93061004297 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 93061004298 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 93061004299 Peptidase family M23; Region: Peptidase_M23; pfam01551 93061004300 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 93061004301 N-acetyl-D-glucosamine binding site [chemical binding]; other site 93061004302 catalytic residue [active] 93061004303 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 93061004304 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 93061004305 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 93061004306 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 93061004307 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 93061004308 oligomerization interface [polypeptide binding]; other site 93061004309 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 93061004310 Phage capsid family; Region: Phage_capsid; pfam05065 93061004311 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 93061004312 oligomer interface [polypeptide binding]; other site 93061004313 active site residues [active] 93061004314 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 93061004315 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 93061004316 Phage Terminase; Region: Terminase_1; cl19862 93061004317 Phage terminase, small subunit; Region: Terminase_4; pfam05119 93061004318 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 93061004319 active site 93061004320 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 93061004321 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 93061004322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93061004323 ATP binding site [chemical binding]; other site 93061004324 putative Mg++ binding site [ion binding]; other site 93061004325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93061004326 nucleotide binding region [chemical binding]; other site 93061004327 ATP-binding site [chemical binding]; other site 93061004328 VRR-NUC domain; Region: VRR_NUC; pfam08774 93061004329 Virulence-associated protein E; Region: VirE; pfam05272 93061004330 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 93061004331 Transcriptional activator RinB; Region: RinB; pfam06116 93061004332 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 93061004333 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 93061004334 trimer interface [polypeptide binding]; other site 93061004335 active site 93061004336 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 93061004337 YopX protein; Region: YopX; pfam09643 93061004338 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 93061004339 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 93061004340 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 93061004341 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 93061004342 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 93061004343 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 93061004344 active site 93061004345 DNA binding site [nucleotide binding] 93061004346 catalytic site [active] 93061004347 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 93061004348 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 93061004349 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 93061004350 Homeodomain-like domain; Region: HTH_23; pfam13384 93061004351 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 93061004352 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 93061004353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93061004354 non-specific DNA binding site [nucleotide binding]; other site 93061004355 salt bridge; other site 93061004356 sequence-specific DNA binding site [nucleotide binding]; other site 93061004357 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93061004358 non-specific DNA binding site [nucleotide binding]; other site 93061004359 salt bridge; other site 93061004360 sequence-specific DNA binding site [nucleotide binding]; other site 93061004361 Predicted transcriptional regulator [Transcription]; Region: COG2932 93061004362 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 93061004363 Catalytic site [active] 93061004364 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 93061004365 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 93061004366 active site 93061004367 catalytic site [active] 93061004368 substrate binding site [chemical binding]; other site 93061004369 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 93061004370 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 93061004371 Int/Topo IB signature motif; other site 93061004372 Adhesin lipoprotein; Region: Lipoprotein_7; pfam01540 93061004373 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 93061004374 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 93061004375 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 93061004376 dimerization interface [polypeptide binding]; other site 93061004377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 93061004378 dimer interface [polypeptide binding]; other site 93061004379 phosphorylation site [posttranslational modification] 93061004380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061004381 ATP binding site [chemical binding]; other site 93061004382 Mg2+ binding site [ion binding]; other site 93061004383 G-X-G motif; other site 93061004384 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 93061004385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061004386 active site 93061004387 phosphorylation site [posttranslational modification] 93061004388 intermolecular recognition site; other site 93061004389 dimerization interface [polypeptide binding]; other site 93061004390 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93061004391 DNA binding site [nucleotide binding] 93061004392 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 93061004393 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93061004394 RNA binding surface [nucleotide binding]; other site 93061004395 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 93061004396 active site 93061004397 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 93061004398 ScpA/B protein; Region: ScpA_ScpB; cl00598 93061004399 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 93061004400 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 93061004401 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 93061004402 active site 93061004403 Int/Topo IB signature motif; other site 93061004404 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 93061004405 metal binding site 2 [ion binding]; metal-binding site 93061004406 putative DNA binding helix; other site 93061004407 metal binding site 1 [ion binding]; metal-binding site 93061004408 dimer interface [polypeptide binding]; other site 93061004409 structural Zn2+ binding site [ion binding]; other site 93061004410 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 93061004411 dimer interface [polypeptide binding]; other site 93061004412 ADP-ribose binding site [chemical binding]; other site 93061004413 active site 93061004414 nudix motif; other site 93061004415 metal binding site [ion binding]; metal-binding site 93061004416 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 93061004417 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 93061004418 active site 93061004419 catalytic tetrad [active] 93061004420 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 93061004421 classical (c) SDRs; Region: SDR_c; cd05233 93061004422 NAD(P) binding site [chemical binding]; other site 93061004423 active site 93061004424 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 93061004425 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 93061004426 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 93061004427 ribonuclease Z; Region: RNase_Z; TIGR02651 93061004428 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 93061004429 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 93061004430 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 93061004431 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 93061004432 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 93061004433 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 93061004434 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 93061004435 Ca binding site [ion binding]; other site 93061004436 active site 93061004437 catalytic site [active] 93061004438 Transcriptional regulators [Transcription]; Region: PurR; COG1609 93061004439 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 93061004440 DNA binding site [nucleotide binding] 93061004441 domain linker motif; other site 93061004442 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 93061004443 putative ligand binding site [chemical binding]; other site 93061004444 putative dimerization interface [polypeptide binding]; other site 93061004445 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 93061004446 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 93061004447 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 93061004448 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 93061004449 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 93061004450 peptidase T-like protein; Region: PepT-like; TIGR01883 93061004451 metal binding site [ion binding]; metal-binding site 93061004452 putative dimer interface [polypeptide binding]; other site 93061004453 Predicted membrane protein [Function unknown]; Region: COG4129 93061004454 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 93061004455 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 93061004456 Disulphide isomerase; Region: Disulph_isomer; pfam06491 93061004457 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 93061004458 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 93061004459 E3 interaction surface; other site 93061004460 lipoyl attachment site [posttranslational modification]; other site 93061004461 e3 binding domain; Region: E3_binding; pfam02817 93061004462 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 93061004463 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 93061004464 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 93061004465 alpha subunit interface [polypeptide binding]; other site 93061004466 TPP binding site [chemical binding]; other site 93061004467 heterodimer interface [polypeptide binding]; other site 93061004468 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 93061004469 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 93061004470 tetramer interface [polypeptide binding]; other site 93061004471 TPP-binding site [chemical binding]; other site 93061004472 heterodimer interface [polypeptide binding]; other site 93061004473 phosphorylation loop region [posttranslational modification] 93061004474 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 93061004475 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 93061004476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93061004477 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 93061004478 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 93061004479 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 93061004480 Walker A/P-loop; other site 93061004481 ATP binding site [chemical binding]; other site 93061004482 Q-loop/lid; other site 93061004483 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 93061004484 ABC transporter signature motif; other site 93061004485 Walker B; other site 93061004486 D-loop; other site 93061004487 H-loop/switch region; other site 93061004488 arginine repressor; Provisional; Region: PRK04280 93061004489 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 93061004490 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 93061004491 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 93061004492 substrate binding pocket [chemical binding]; other site 93061004493 chain length determination region; other site 93061004494 substrate-Mg2+ binding site; other site 93061004495 catalytic residues [active] 93061004496 aspartate-rich region 1; other site 93061004497 active site lid residues [active] 93061004498 aspartate-rich region 2; other site 93061004499 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 93061004500 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 93061004501 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 93061004502 generic binding surface II; other site 93061004503 generic binding surface I; other site 93061004504 Nucleoporin complex subunit 54; Region: Nup54; pfam13874 93061004505 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 93061004506 putative RNA binding site [nucleotide binding]; other site 93061004507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 93061004508 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 93061004509 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 93061004510 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 93061004511 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 93061004512 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 93061004513 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 93061004514 carboxyltransferase (CT) interaction site; other site 93061004515 biotinylation site [posttranslational modification]; other site 93061004516 elongation factor P; Validated; Region: PRK00529 93061004517 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 93061004518 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 93061004519 RNA binding site [nucleotide binding]; other site 93061004520 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 93061004521 RNA binding site [nucleotide binding]; other site 93061004522 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 93061004523 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 93061004524 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 93061004525 active site 93061004526 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 93061004527 Nucleopolyhedrovirus protein of unknown function (DUF912); Region: DUF912; pfam06024 93061004528 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 93061004529 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 93061004530 active site residue [active] 93061004531 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 93061004532 tetramer interface [polypeptide binding]; other site 93061004533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061004534 catalytic residue [active] 93061004535 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 93061004536 tetramer interface [polypeptide binding]; other site 93061004537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061004538 catalytic residue [active] 93061004539 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 93061004540 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 93061004541 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 93061004542 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 93061004543 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 93061004544 ADP binding site [chemical binding]; other site 93061004545 magnesium binding site [ion binding]; other site 93061004546 putative shikimate binding site; other site 93061004547 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 93061004548 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 93061004549 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 93061004550 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 93061004551 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 93061004552 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 93061004553 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 93061004554 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 93061004555 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 93061004556 Walker A motif; other site 93061004557 ATP binding site [chemical binding]; other site 93061004558 Walker B motif; other site 93061004559 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 93061004560 Uncharacterized conserved protein [Function unknown]; Region: COG0011 93061004561 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 93061004562 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 93061004563 nucleotide binding site [chemical binding]; other site 93061004564 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 93061004565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 93061004566 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 93061004567 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 93061004568 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 93061004569 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 93061004570 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 93061004571 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 93061004572 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 93061004573 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 93061004574 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 93061004575 metal binding site 2 [ion binding]; metal-binding site 93061004576 putative DNA binding helix; other site 93061004577 metal binding site 1 [ion binding]; metal-binding site 93061004578 dimer interface [polypeptide binding]; other site 93061004579 structural Zn2+ binding site [ion binding]; other site 93061004580 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 93061004581 ABC-ATPase subunit interface; other site 93061004582 dimer interface [polypeptide binding]; other site 93061004583 putative PBP binding regions; other site 93061004584 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 93061004585 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 93061004586 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 93061004587 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 93061004588 AP (apurinic/apyrimidinic) site pocket; other site 93061004589 DNA interaction; other site 93061004590 Metal-binding active site; metal-binding site 93061004591 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 93061004592 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 93061004593 ATP binding site [chemical binding]; other site 93061004594 putative Mg++ binding site [ion binding]; other site 93061004595 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93061004596 nucleotide binding region [chemical binding]; other site 93061004597 ATP-binding site [chemical binding]; other site 93061004598 Uncharacterized conserved protein [Function unknown]; Region: COG0327 93061004599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 93061004600 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 93061004601 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 93061004602 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 93061004603 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 93061004604 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 93061004605 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 93061004606 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 93061004607 DNA binding residues [nucleotide binding] 93061004608 DNA primase, catalytic core; Region: dnaG; TIGR01391 93061004609 CHC2 zinc finger; Region: zf-CHC2; pfam01807 93061004610 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 93061004611 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 93061004612 active site 93061004613 metal binding site [ion binding]; metal-binding site 93061004614 interdomain interaction site; other site 93061004615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 93061004616 HTH domain; Region: HTH_11; cl17392 93061004617 FOG: CBS domain [General function prediction only]; Region: COG0517 93061004618 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 93061004619 glycyl-tRNA synthetase; Provisional; Region: PRK04173 93061004620 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 93061004621 dimer interface [polypeptide binding]; other site 93061004622 motif 1; other site 93061004623 active site 93061004624 motif 2; other site 93061004625 motif 3; other site 93061004626 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 93061004627 anticodon binding site; other site 93061004628 DNA repair protein RecO; Region: reco; TIGR00613 93061004629 Recombination protein O N terminal; Region: RecO_N; pfam11967 93061004630 Recombination protein O C terminal; Region: RecO_C; pfam02565 93061004631 GTPase Era; Reviewed; Region: era; PRK00089 93061004632 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 93061004633 G1 box; other site 93061004634 GTP/Mg2+ binding site [chemical binding]; other site 93061004635 Switch I region; other site 93061004636 G2 box; other site 93061004637 Switch II region; other site 93061004638 G3 box; other site 93061004639 G4 box; other site 93061004640 G5 box; other site 93061004641 KH domain; Region: KH_2; pfam07650 93061004642 cytidine deaminase, homotetrameric; Region: cyt_deam_tetra; TIGR01354 93061004643 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 93061004644 active site 93061004645 catalytic motif [active] 93061004646 Zn binding site [ion binding]; other site 93061004647 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 93061004648 trimer interface [polypeptide binding]; other site 93061004649 putative active site [active] 93061004650 Zn binding site [ion binding]; other site 93061004651 metal-binding heat shock protein; Provisional; Region: PRK00016 93061004652 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 93061004653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93061004654 ATP binding site [chemical binding]; other site 93061004655 putative Mg++ binding site [ion binding]; other site 93061004656 DNA translocase FtsK; Provisional; Region: PRK10263 93061004657 hypothetical protein; Provisional; Region: PRK13665 93061004658 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 93061004659 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 93061004660 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 93061004661 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 93061004662 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93061004663 FeS/SAM binding site; other site 93061004664 TRAM domain; Region: TRAM; cl01282 93061004665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 93061004666 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 93061004667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061004668 S-adenosylmethionine binding site [chemical binding]; other site 93061004669 chaperone protein DnaJ; Provisional; Region: PRK14280 93061004670 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 93061004671 HSP70 interaction site [polypeptide binding]; other site 93061004672 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 93061004673 substrate binding site [polypeptide binding]; other site 93061004674 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 93061004675 Zn binding sites [ion binding]; other site 93061004676 dimer interface [polypeptide binding]; other site 93061004677 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 93061004678 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 93061004679 nucleotide binding site [chemical binding]; other site 93061004680 NEF interaction site [polypeptide binding]; other site 93061004681 SBD interface [polypeptide binding]; other site 93061004682 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 93061004683 dimer interface [polypeptide binding]; other site 93061004684 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 93061004685 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 93061004686 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 93061004687 HrcA protein C terminal domain; Region: HrcA; pfam01628 93061004688 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 93061004689 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93061004690 FeS/SAM binding site; other site 93061004691 HemN C-terminal domain; Region: HemN_C; pfam06969 93061004692 GTP-binding protein LepA; Provisional; Region: PRK05433 93061004693 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 93061004694 G1 box; other site 93061004695 putative GEF interaction site [polypeptide binding]; other site 93061004696 GTP/Mg2+ binding site [chemical binding]; other site 93061004697 Switch I region; other site 93061004698 G2 box; other site 93061004699 G3 box; other site 93061004700 Switch II region; other site 93061004701 G4 box; other site 93061004702 G5 box; other site 93061004703 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 93061004704 Elongation Factor G, domain II; Region: EFG_II; pfam14492 93061004705 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 93061004706 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 93061004707 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 93061004708 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 93061004709 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 93061004710 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 93061004711 Competence protein; Region: Competence; pfam03772 93061004712 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 93061004713 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 93061004714 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 93061004715 catalytic motif [active] 93061004716 Zn binding site [ion binding]; other site 93061004717 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 93061004718 SLBB domain; Region: SLBB; pfam10531 93061004719 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 93061004720 Methyltransferase domain; Region: Methyltransf_31; pfam13847 93061004721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061004722 S-adenosylmethionine binding site [chemical binding]; other site 93061004723 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 93061004724 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 93061004725 Zn2+ binding site [ion binding]; other site 93061004726 Mg2+ binding site [ion binding]; other site 93061004727 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 93061004728 active site 93061004729 (T/H)XGH motif; other site 93061004730 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 93061004731 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 93061004732 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 93061004733 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 93061004734 shikimate binding site; other site 93061004735 NAD(P) binding site [chemical binding]; other site 93061004736 GTPase YqeH; Provisional; Region: PRK13796 93061004737 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 93061004738 GTP/Mg2+ binding site [chemical binding]; other site 93061004739 G4 box; other site 93061004740 G5 box; other site 93061004741 G1 box; other site 93061004742 Switch I region; other site 93061004743 G2 box; other site 93061004744 G3 box; other site 93061004745 Switch II region; other site 93061004746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061004747 active site 93061004748 motif I; other site 93061004749 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 93061004750 motif II; other site 93061004751 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 93061004752 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 93061004753 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 93061004754 Fic family protein [Function unknown]; Region: COG3177 93061004755 Fic/DOC family; Region: Fic; pfam02661 93061004756 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 93061004757 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 93061004758 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 93061004759 putative active site [active] 93061004760 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 93061004761 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 93061004762 ATP-grasp domain; Region: ATP-grasp_4; cl17255 93061004763 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 93061004764 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 93061004765 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 93061004766 carboxyltransferase (CT) interaction site; other site 93061004767 biotinylation site [posttranslational modification]; other site 93061004768 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 93061004769 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 93061004770 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 93061004771 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 93061004772 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 93061004773 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 93061004774 ATP-binding site [chemical binding]; other site 93061004775 Sugar specificity; other site 93061004776 Pyrimidine base specificity; other site 93061004777 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 93061004778 putative protease; Provisional; Region: PRK15452 93061004779 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 93061004780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061004781 S-adenosylmethionine binding site [chemical binding]; other site 93061004782 hypothetical protein; Provisional; Region: PRK13678 93061004783 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 93061004784 hypothetical protein; Provisional; Region: PRK05473 93061004785 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 93061004786 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 93061004787 motif 1; other site 93061004788 active site 93061004789 motif 2; other site 93061004790 motif 3; other site 93061004791 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 93061004792 DHHA1 domain; Region: DHHA1; pfam02272 93061004793 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 93061004794 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 93061004795 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 93061004796 AAA domain; Region: AAA_30; pfam13604 93061004797 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 93061004798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93061004799 binding surface 93061004800 TPR motif; other site 93061004801 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 93061004802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93061004803 binding surface 93061004804 TPR motif; other site 93061004805 TPR repeat; Region: TPR_11; pfam13414 93061004806 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 93061004807 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93061004808 catalytic residue [active] 93061004809 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 93061004810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 93061004811 recombination factor protein RarA; Reviewed; Region: PRK13342 93061004812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061004813 Walker A motif; other site 93061004814 ATP binding site [chemical binding]; other site 93061004815 Walker B motif; other site 93061004816 arginine finger; other site 93061004817 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 93061004818 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 93061004819 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 93061004820 putative ATP binding site [chemical binding]; other site 93061004821 putative substrate interface [chemical binding]; other site 93061004822 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 93061004823 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 93061004824 dimer interface [polypeptide binding]; other site 93061004825 anticodon binding site; other site 93061004826 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 93061004827 homodimer interface [polypeptide binding]; other site 93061004828 motif 1; other site 93061004829 active site 93061004830 motif 2; other site 93061004831 GAD domain; Region: GAD; pfam02938 93061004832 motif 3; other site 93061004833 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 93061004834 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 93061004835 dimer interface [polypeptide binding]; other site 93061004836 motif 1; other site 93061004837 active site 93061004838 motif 2; other site 93061004839 motif 3; other site 93061004840 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cd00738 93061004841 anticodon binding site; other site 93061004842 Bacterial SH3 domain homologues; Region: SH3b; smart00287 93061004843 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 93061004844 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 93061004845 active site 93061004846 metal binding site [ion binding]; metal-binding site 93061004847 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 93061004848 putative active site [active] 93061004849 dimerization interface [polypeptide binding]; other site 93061004850 putative tRNAtyr binding site [nucleotide binding]; other site 93061004851 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 93061004852 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 93061004853 Zn2+ binding site [ion binding]; other site 93061004854 Mg2+ binding site [ion binding]; other site 93061004855 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 93061004856 synthetase active site [active] 93061004857 NTP binding site [chemical binding]; other site 93061004858 metal binding site [ion binding]; metal-binding site 93061004859 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 93061004860 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 93061004861 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93061004862 active site 93061004863 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 93061004864 DHH family; Region: DHH; pfam01368 93061004865 DHHA1 domain; Region: DHHA1; pfam02272 93061004866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 93061004867 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 93061004868 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 93061004869 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 93061004870 Protein export membrane protein; Region: SecD_SecF; pfam02355 93061004871 Preprotein translocase subunit; Region: YajC; pfam02699 93061004872 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 93061004873 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 93061004874 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 93061004875 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 93061004876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061004877 Walker A motif; other site 93061004878 ATP binding site [chemical binding]; other site 93061004879 Walker B motif; other site 93061004880 arginine finger; other site 93061004881 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 93061004882 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 93061004883 RuvA N terminal domain; Region: RuvA_N; pfam01330 93061004884 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 93061004885 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 93061004886 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 93061004887 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 93061004888 GTPase CgtA; Reviewed; Region: obgE; PRK12297 93061004889 GTP1/OBG; Region: GTP1_OBG; pfam01018 93061004890 Obg GTPase; Region: Obg; cd01898 93061004891 G1 box; other site 93061004892 GTP/Mg2+ binding site [chemical binding]; other site 93061004893 Switch I region; other site 93061004894 G2 box; other site 93061004895 G3 box; other site 93061004896 Switch II region; other site 93061004897 G4 box; other site 93061004898 G5 box; other site 93061004899 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 93061004900 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 93061004901 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 93061004902 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 93061004903 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 93061004904 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 93061004905 hypothetical protein; Reviewed; Region: PRK00024 93061004906 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 93061004907 MPN+ (JAMM) motif; other site 93061004908 Zinc-binding site [ion binding]; other site 93061004909 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 93061004910 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 93061004911 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 93061004912 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 93061004913 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 93061004914 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 93061004915 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 93061004916 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 93061004917 active site 93061004918 HIGH motif; other site 93061004919 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 93061004920 KMSKS motif; other site 93061004921 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 93061004922 tRNA binding surface [nucleotide binding]; other site 93061004923 anticodon binding site; other site 93061004924 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 93061004925 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 93061004926 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 93061004927 Putative ammonia monooxygenase; Region: AmoA; pfam05145 93061004928 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 93061004929 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 93061004930 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 93061004931 inhibitor-cofactor binding pocket; inhibition site 93061004932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061004933 catalytic residue [active] 93061004934 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 93061004935 dimer interface [polypeptide binding]; other site 93061004936 active site 93061004937 Schiff base residues; other site 93061004938 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 93061004939 active site 93061004940 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 93061004941 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 93061004942 domain interfaces; other site 93061004943 active site 93061004944 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 93061004945 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 93061004946 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 93061004947 tRNA; other site 93061004948 putative tRNA binding site [nucleotide binding]; other site 93061004949 putative NADP binding site [chemical binding]; other site 93061004950 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 93061004951 Predicted GTPase [General function prediction only]; Region: COG0218 93061004952 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 93061004953 G1 box; other site 93061004954 GTP/Mg2+ binding site [chemical binding]; other site 93061004955 Switch I region; other site 93061004956 G2 box; other site 93061004957 G3 box; other site 93061004958 Switch II region; other site 93061004959 G4 box; other site 93061004960 G5 box; other site 93061004961 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 93061004962 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 93061004963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061004964 Walker A motif; other site 93061004965 ATP binding site [chemical binding]; other site 93061004966 Walker B motif; other site 93061004967 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 93061004968 trigger factor; Provisional; Region: tig; PRK01490 93061004969 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 93061004970 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 93061004971 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 93061004972 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 93061004973 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 93061004974 23S rRNA binding site [nucleotide binding]; other site 93061004975 L21 binding site [polypeptide binding]; other site 93061004976 L13 binding site [polypeptide binding]; other site 93061004977 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 93061004978 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 93061004979 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 93061004980 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 93061004981 lysine transporter; Provisional; Region: PRK10836 93061004982 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 93061004983 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 93061004984 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 93061004985 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 93061004986 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 93061004987 active site 93061004988 dimer interface [polypeptide binding]; other site 93061004989 motif 1; other site 93061004990 motif 2; other site 93061004991 motif 3; other site 93061004992 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 93061004993 anticodon binding site; other site 93061004994 primosomal protein DnaI; Reviewed; Region: PRK08939 93061004995 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 93061004996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061004997 Walker A motif; other site 93061004998 ATP binding site [chemical binding]; other site 93061004999 Walker B motif; other site 93061005000 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 93061005001 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 93061005002 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 93061005003 ATP cone domain; Region: ATP-cone; pfam03477 93061005004 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 93061005005 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 93061005006 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 93061005007 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 93061005008 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 93061005009 CoA-binding site [chemical binding]; other site 93061005010 ATP-binding [chemical binding]; other site 93061005011 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 93061005012 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 93061005013 DNA binding site [nucleotide binding] 93061005014 catalytic residue [active] 93061005015 H2TH interface [polypeptide binding]; other site 93061005016 putative catalytic residues [active] 93061005017 turnover-facilitating residue; other site 93061005018 intercalation triad [nucleotide binding]; other site 93061005019 8OG recognition residue [nucleotide binding]; other site 93061005020 putative reading head residues; other site 93061005021 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 93061005022 DNA polymerase I; Provisional; Region: PRK05755 93061005023 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 93061005024 active site 93061005025 metal binding site 1 [ion binding]; metal-binding site 93061005026 putative 5' ssDNA interaction site; other site 93061005027 metal binding site 3; metal-binding site 93061005028 metal binding site 2 [ion binding]; metal-binding site 93061005029 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 93061005030 putative DNA binding site [nucleotide binding]; other site 93061005031 putative metal binding site [ion binding]; other site 93061005032 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 93061005033 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 93061005034 active site 93061005035 DNA binding site [nucleotide binding] 93061005036 catalytic site [active] 93061005037 HAMP domain; Region: HAMP; pfam00672 93061005038 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 93061005039 PAS domain; Region: PAS_8; pfam13188 93061005040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 93061005041 dimer interface [polypeptide binding]; other site 93061005042 phosphorylation site [posttranslational modification] 93061005043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061005044 ATP binding site [chemical binding]; other site 93061005045 Mg2+ binding site [ion binding]; other site 93061005046 G-X-G motif; other site 93061005047 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 93061005048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061005049 active site 93061005050 phosphorylation site [posttranslational modification] 93061005051 intermolecular recognition site; other site 93061005052 dimerization interface [polypeptide binding]; other site 93061005053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93061005054 DNA binding site [nucleotide binding] 93061005055 isocitrate dehydrogenase; Reviewed; Region: PRK07006 93061005056 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 93061005057 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 93061005058 oxalacetate binding site [chemical binding]; other site 93061005059 citrylCoA binding site [chemical binding]; other site 93061005060 coenzyme A binding site [chemical binding]; other site 93061005061 catalytic triad [active] 93061005062 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 93061005063 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 93061005064 pyruvate kinase; Provisional; Region: PRK06354 93061005065 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 93061005066 domain interfaces; other site 93061005067 active site 93061005068 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 93061005069 6-phosphofructokinase; Provisional; Region: PRK03202 93061005070 dimerization interface [polypeptide binding]; other site 93061005071 allosteric effector site; other site 93061005072 active site 93061005073 ADP/pyrophosphate binding site [chemical binding]; other site 93061005074 fructose-1,6-bisphosphate binding site; other site 93061005075 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 93061005076 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 93061005077 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 93061005078 Malic enzyme, N-terminal domain; Region: malic; pfam00390 93061005079 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 93061005080 putative NAD(P) binding site [chemical binding]; other site 93061005081 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 93061005082 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 93061005083 active site 93061005084 PHP Thumb interface [polypeptide binding]; other site 93061005085 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 93061005086 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 93061005087 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 93061005088 generic binding surface I; other site 93061005089 generic binding surface II; other site 93061005090 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 93061005091 DHH family; Region: DHH; pfam01368 93061005092 DHHA1 domain; Region: DHHA1; pfam02272 93061005093 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 93061005094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 93061005095 DNA-binding site [nucleotide binding]; DNA binding site 93061005096 DRTGG domain; Region: DRTGG; pfam07085 93061005097 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 93061005098 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 93061005099 active site 2 [active] 93061005100 active site 1 [active] 93061005101 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 93061005102 Ligand Binding Site [chemical binding]; other site 93061005103 metal-dependent hydrolase; Provisional; Region: PRK00685 93061005104 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 93061005105 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 93061005106 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 93061005107 active site 93061005108 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 93061005109 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 93061005110 hexamer interface [polypeptide binding]; other site 93061005111 ligand binding site [chemical binding]; other site 93061005112 putative active site [active] 93061005113 NAD(P) binding site [chemical binding]; other site 93061005114 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 93061005115 Ligand Binding Site [chemical binding]; other site 93061005116 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 93061005117 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 93061005118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061005119 S-adenosylmethionine binding site [chemical binding]; other site 93061005120 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 93061005121 dimer interface [polypeptide binding]; other site 93061005122 catalytic triad [active] 93061005123 peroxidatic and resolving cysteines [active] 93061005124 hypothetical protein; Provisional; Region: PRK10621 93061005125 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 93061005126 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 93061005127 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 93061005128 Ligand Binding Site [chemical binding]; other site 93061005129 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 93061005130 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93061005131 catalytic residue [active] 93061005132 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 93061005133 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 93061005134 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 93061005135 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 93061005136 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93061005137 RNA binding surface [nucleotide binding]; other site 93061005138 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 93061005139 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 93061005140 active site 93061005141 catalytic site [active] 93061005142 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 93061005143 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 93061005144 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93061005145 catalytic residue [active] 93061005146 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 93061005147 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 93061005148 ligand binding site [chemical binding]; other site 93061005149 NAD binding site [chemical binding]; other site 93061005150 dimerization interface [polypeptide binding]; other site 93061005151 catalytic site [active] 93061005152 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 93061005153 putative L-serine binding site [chemical binding]; other site 93061005154 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 93061005155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061005156 motif II; other site 93061005157 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 93061005158 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 93061005159 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 93061005160 active site turn [active] 93061005161 phosphorylation site [posttranslational modification] 93061005162 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 93061005163 putative acyl-acceptor binding pocket; other site 93061005164 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 93061005165 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 93061005166 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 93061005167 protein binding site [polypeptide binding]; other site 93061005168 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 93061005169 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 93061005170 active site 93061005171 HIGH motif; other site 93061005172 dimer interface [polypeptide binding]; other site 93061005173 KMSKS motif; other site 93061005174 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93061005175 RNA binding surface [nucleotide binding]; other site 93061005176 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 93061005177 Transglycosylase; Region: Transgly; pfam00912 93061005178 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 93061005179 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 93061005180 NEAr Transporter domain; Region: NEAT; smart00725 93061005181 NEAr Transporter domain; Region: NEAT; smart00725 93061005182 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 93061005183 heme-binding site [chemical binding]; other site 93061005184 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 93061005185 Potassium binding sites [ion binding]; other site 93061005186 Cesium cation binding sites [ion binding]; other site 93061005187 acetyl-CoA synthetase; Provisional; Region: PRK04319 93061005188 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 93061005189 acyl-activating enzyme (AAE) consensus motif; other site 93061005190 AMP binding site [chemical binding]; other site 93061005191 active site 93061005192 CoA binding site [chemical binding]; other site 93061005193 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 93061005194 active site 93061005195 Zn binding site [ion binding]; other site 93061005196 catabolite control protein A; Region: ccpA; TIGR01481 93061005197 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 93061005198 DNA binding site [nucleotide binding] 93061005199 domain linker motif; other site 93061005200 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 93061005201 dimerization interface [polypeptide binding]; other site 93061005202 effector binding site; other site 93061005203 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 93061005204 Chorismate mutase type II; Region: CM_2; cl00693 93061005205 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 93061005206 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 93061005207 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 93061005208 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 93061005209 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 93061005210 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 93061005211 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 93061005212 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 93061005213 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 93061005214 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 93061005215 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 93061005216 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 93061005217 putative tRNA-binding site [nucleotide binding]; other site 93061005218 hypothetical protein; Provisional; Region: PRK13668 93061005219 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 93061005220 catalytic residues [active] 93061005221 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 93061005222 oligomer interface [polypeptide binding]; other site 93061005223 active site 93061005224 metal binding site [ion binding]; metal-binding site 93061005225 Predicted small secreted protein [Function unknown]; Region: COG5584 93061005226 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 93061005227 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 93061005228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061005229 S-adenosylmethionine binding site [chemical binding]; other site 93061005230 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 93061005231 Phosphotransferase enzyme family; Region: APH; pfam01636 93061005232 active site 93061005233 ATP binding site [chemical binding]; other site 93061005234 substrate binding site [chemical binding]; other site 93061005235 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 93061005236 homodimer interface [polypeptide binding]; other site 93061005237 substrate-cofactor binding pocket; other site 93061005238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061005239 catalytic residue [active] 93061005240 dipeptidase PepV; Reviewed; Region: PRK07318 93061005241 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 93061005242 active site 93061005243 metal binding site [ion binding]; metal-binding site 93061005244 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 93061005245 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93061005246 RNA binding surface [nucleotide binding]; other site 93061005247 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 93061005248 active site 93061005249 uracil binding [chemical binding]; other site 93061005250 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 93061005251 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 93061005252 HI0933-like protein; Region: HI0933_like; pfam03486 93061005253 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 93061005254 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 93061005255 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 93061005256 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 93061005257 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005258 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005259 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005260 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005261 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005262 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005263 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005264 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005265 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005266 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005267 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005268 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005269 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005270 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005271 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005272 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005273 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061005274 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 93061005275 active site residue [active] 93061005276 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 93061005277 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 93061005278 active site 93061005279 HIGH motif; other site 93061005280 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 93061005281 KMSKS motif; other site 93061005282 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 93061005283 tRNA binding surface [nucleotide binding]; other site 93061005284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061005285 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061005286 putative substrate translocation pore; other site 93061005287 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 93061005288 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 93061005289 Methyltransferase domain; Region: Methyltransf_31; pfam13847 93061005290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061005291 S-adenosylmethionine binding site [chemical binding]; other site 93061005292 MarR family; Region: MarR_2; cl17246 93061005293 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061005294 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 93061005295 Putative lysophospholipase; Region: Hydrolase_4; cl19140 93061005296 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 93061005297 Proline dehydrogenase; Region: Pro_dh; pfam01619 93061005298 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 93061005299 homopentamer interface [polypeptide binding]; other site 93061005300 active site 93061005301 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 93061005302 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 93061005303 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 93061005304 dimerization interface [polypeptide binding]; other site 93061005305 active site 93061005306 Riboflavin synthase alpha chain [Coenzyme metabolism]; Region: RibC; COG0307 93061005307 Lumazine binding domain; Region: Lum_binding; pfam00677 93061005308 Lumazine binding domain; Region: Lum_binding; pfam00677 93061005309 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 93061005310 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 93061005311 catalytic motif [active] 93061005312 Zn binding site [ion binding]; other site 93061005313 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 93061005314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 93061005315 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 93061005316 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 93061005317 dimerization interface [polypeptide binding]; other site 93061005318 putative DNA binding site [nucleotide binding]; other site 93061005319 putative Zn2+ binding site [ion binding]; other site 93061005320 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 93061005321 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 93061005322 transmembrane helices; other site 93061005323 Low molecular weight phosphatase family; Region: LMWPc; cd00115 93061005324 active site 93061005325 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 93061005326 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 93061005327 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 93061005328 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 93061005329 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 93061005330 CAAX protease self-immunity; Region: Abi; pfam02517 93061005331 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 93061005332 active site 93061005333 intersubunit interactions; other site 93061005334 catalytic residue [active] 93061005335 camphor resistance protein CrcB; Provisional; Region: PRK14201 93061005336 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 93061005337 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 93061005338 active site 93061005339 catalytic tetrad [active] 93061005340 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 93061005341 S-adenosylmethionine synthetase; Validated; Region: PRK05250 93061005342 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 93061005343 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 93061005344 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 93061005345 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 93061005346 active site 93061005347 substrate-binding site [chemical binding]; other site 93061005348 metal-binding site [ion binding] 93061005349 ATP binding site [chemical binding]; other site 93061005350 Transposase IS200 like; Region: Y1_Tnp; pfam01797 93061005351 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 93061005352 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 93061005353 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 93061005354 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 93061005355 nudix motif; other site 93061005356 Haemolytic domain; Region: Haemolytic; pfam01809 93061005357 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 93061005358 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 93061005359 metal binding site [ion binding]; metal-binding site 93061005360 substrate binding pocket [chemical binding]; other site 93061005361 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 93061005362 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 93061005363 acyl-activating enzyme (AAE) consensus motif; other site 93061005364 putative AMP binding site [chemical binding]; other site 93061005365 putative active site [active] 93061005366 putative CoA binding site [chemical binding]; other site 93061005367 Excalibur calcium-binding domain; Region: Excalibur; smart00894 93061005368 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 93061005369 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 93061005370 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 93061005371 Domain of unknown function (DUF955); Region: DUF955; pfam06114 93061005372 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 93061005373 Transposase; Region: HTH_Tnp_1; cl17663 93061005374 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 93061005375 AAA ATPase domain; Region: AAA_16; pfam13191 93061005376 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 93061005377 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 93061005378 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 93061005379 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 93061005380 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 93061005381 HsdM N-terminal domain; Region: HsdM_N; pfam12161 93061005382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061005383 S-adenosylmethionine binding site [chemical binding]; other site 93061005384 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 93061005385 Trypsin; Region: Trypsin; pfam00089 93061005386 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 93061005387 Trypsin; Region: Trypsin; pfam00089 93061005388 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 93061005389 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 93061005390 Trypsin; Region: Trypsin; pfam00089 93061005391 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 93061005392 Trypsin; Region: Trypsin; pfam00089 93061005393 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 93061005394 Trypsin; Region: Trypsin; pfam00089 93061005395 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 93061005396 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 93061005397 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 93061005398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061005399 Walker A/P-loop; other site 93061005400 ATP binding site [chemical binding]; other site 93061005401 Q-loop/lid; other site 93061005402 ABC transporter signature motif; other site 93061005403 Walker B; other site 93061005404 D-loop; other site 93061005405 H-loop/switch region; other site 93061005406 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 93061005407 Subtilase family; Region: Peptidase_S8; pfam00082 93061005408 active site 93061005409 catalytic triad [active] 93061005410 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 93061005411 Flavoprotein; Region: Flavoprotein; pfam02441 93061005412 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 93061005413 active site 93061005414 zinc binding site [ion binding]; other site 93061005415 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 93061005416 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 93061005417 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 93061005418 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 93061005419 beta-channel forming cytolysin; Region: hlyII; TIGR01002 93061005420 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 93061005421 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 93061005422 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 93061005423 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 93061005424 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 93061005425 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 93061005426 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93061005427 ferrochelatase; Provisional; Region: PRK12435 93061005428 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 93061005429 C-terminal domain interface [polypeptide binding]; other site 93061005430 active site 93061005431 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 93061005432 active site 93061005433 N-terminal domain interface [polypeptide binding]; other site 93061005434 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 93061005435 substrate binding site [chemical binding]; other site 93061005436 active site 93061005437 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 93061005438 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 93061005439 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 93061005440 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 93061005441 Walker A/P-loop; other site 93061005442 ATP binding site [chemical binding]; other site 93061005443 Q-loop/lid; other site 93061005444 ABC transporter signature motif; other site 93061005445 Walker B; other site 93061005446 D-loop; other site 93061005447 H-loop/switch region; other site 93061005448 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 93061005449 HIT family signature motif; other site 93061005450 catalytic residue [active] 93061005451 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 93061005452 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 93061005453 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 93061005454 SurA N-terminal domain; Region: SurA_N_3; cl07813 93061005455 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 93061005456 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 93061005457 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 93061005458 generic binding surface II; other site 93061005459 generic binding surface I; other site 93061005460 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 93061005461 Zn2+ binding site [ion binding]; other site 93061005462 Mg2+ binding site [ion binding]; other site 93061005463 Uncharacterized conserved protein [Function unknown]; Region: COG4717 93061005464 AAA domain; Region: AAA_23; pfam13476 93061005465 Walker A/P-loop; other site 93061005466 ATP binding site [chemical binding]; other site 93061005467 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 93061005468 Peptidase family M48; Region: Peptidase_M48; cl12018 93061005469 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 93061005470 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 93061005471 active site 93061005472 metal binding site [ion binding]; metal-binding site 93061005473 DNA binding site [nucleotide binding] 93061005474 hypothetical protein; Provisional; Region: PRK13676 93061005475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 93061005476 Protein of unknown function (DUF445); Region: DUF445; pfam04286 93061005477 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 93061005478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93061005479 non-specific DNA binding site [nucleotide binding]; other site 93061005480 salt bridge; other site 93061005481 sequence-specific DNA binding site [nucleotide binding]; other site 93061005482 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 93061005483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061005484 active site 93061005485 phosphorylation site [posttranslational modification] 93061005486 intermolecular recognition site; other site 93061005487 dimerization interface [polypeptide binding]; other site 93061005488 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 93061005489 DNA binding residues [nucleotide binding] 93061005490 dimerization interface [polypeptide binding]; other site 93061005491 GAF domain; Region: GAF_2; pfam13185 93061005492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 93061005493 Histidine kinase; Region: HisKA_3; pfam07730 93061005494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061005495 ATP binding site [chemical binding]; other site 93061005496 Mg2+ binding site [ion binding]; other site 93061005497 G-X-G motif; other site 93061005498 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 93061005499 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 93061005500 active site 93061005501 fumarate hydratase; Reviewed; Region: fumC; PRK00485 93061005502 Class II fumarases; Region: Fumarase_classII; cd01362 93061005503 active site 93061005504 tetramer interface [polypeptide binding]; other site 93061005505 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 93061005506 active site 93061005507 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 93061005508 epoxyqueuosine reductase; Region: TIGR00276 93061005509 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 93061005510 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 93061005511 HEAT repeats; Region: HEAT_2; pfam13646 93061005512 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 93061005513 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 93061005514 Walker A/P-loop; other site 93061005515 ATP binding site [chemical binding]; other site 93061005516 Q-loop/lid; other site 93061005517 ABC transporter signature motif; other site 93061005518 Walker B; other site 93061005519 D-loop; other site 93061005520 H-loop/switch region; other site 93061005521 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 93061005522 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 93061005523 substrate binding pocket [chemical binding]; other site 93061005524 membrane-bound complex binding site; other site 93061005525 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 93061005526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061005527 dimer interface [polypeptide binding]; other site 93061005528 conserved gate region; other site 93061005529 putative PBP binding loops; other site 93061005530 ABC-ATPase subunit interface; other site 93061005531 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 93061005532 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 93061005533 metal binding site 2 [ion binding]; metal-binding site 93061005534 putative DNA binding helix; other site 93061005535 metal binding site 1 [ion binding]; metal-binding site 93061005536 dimer interface [polypeptide binding]; other site 93061005537 structural Zn2+ binding site [ion binding]; other site 93061005538 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 93061005539 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 93061005540 putative ligand binding site [chemical binding]; other site 93061005541 NAD binding site [chemical binding]; other site 93061005542 catalytic site [active] 93061005543 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 93061005544 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 93061005545 catalytic triad [active] 93061005546 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 93061005547 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 93061005548 inhibitor-cofactor binding pocket; inhibition site 93061005549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061005550 catalytic residue [active] 93061005551 Predicted membrane protein [Function unknown]; Region: COG4129 93061005552 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 93061005553 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 93061005554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93061005555 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 93061005556 Walker A/P-loop; other site 93061005557 ATP binding site [chemical binding]; other site 93061005558 Q-loop/lid; other site 93061005559 ABC transporter signature motif; other site 93061005560 Walker B; other site 93061005561 D-loop; other site 93061005562 H-loop/switch region; other site 93061005563 hypothetical protein; Provisional; Region: PRK13662 93061005564 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 93061005565 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 93061005566 minor groove reading motif; other site 93061005567 helix-hairpin-helix signature motif; other site 93061005568 substrate binding pocket [chemical binding]; other site 93061005569 active site 93061005570 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 93061005571 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 93061005572 DNA binding and oxoG recognition site [nucleotide binding] 93061005573 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 93061005574 ABC-2 type transporter; Region: ABC2_membrane; cl17235 93061005575 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 93061005576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061005577 Walker A/P-loop; other site 93061005578 ATP binding site [chemical binding]; other site 93061005579 Q-loop/lid; other site 93061005580 ABC transporter signature motif; other site 93061005581 Walker B; other site 93061005582 H-loop/switch region; other site 93061005583 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 93061005584 recombination regulator RecX; Provisional; Region: recX; PRK14135 93061005585 glycosyltransferase; Provisional; Region: PRK13481 93061005586 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 93061005587 intracellular protease, PfpI family; Region: PfpI; TIGR01382 93061005588 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 93061005589 proposed catalytic triad [active] 93061005590 conserved cys residue [active] 93061005591 CHAP domain; Region: CHAP; pfam05257 93061005592 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 93061005593 amidase catalytic site [active] 93061005594 Zn binding residues [ion binding]; other site 93061005595 substrate binding site [chemical binding]; other site 93061005596 Bacterial SH3 domain; Region: SH3_5; pfam08460 93061005597 holin, phage phi LC3 family; Region: holin_phiLC3; TIGR01598 93061005598 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 93061005599 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 93061005600 CHAP domain; Region: CHAP; pfam05257 93061005601 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 93061005602 Lysozyme subfamily 2; Region: LYZ2; smart00047 93061005603 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 93061005604 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 93061005605 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 93061005606 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 93061005607 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 93061005608 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 93061005609 active site 93061005610 catalytic triad [active] 93061005611 oxyanion hole [active] 93061005612 Phage tail protein; Region: Sipho_tail; pfam05709 93061005613 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 93061005614 membrane protein P6; Region: PHA01399 93061005615 membrane protein P6; Region: PHA01399 93061005616 putative minor structural protein; Region: PHA01351 93061005617 Phage protein; Region: DUF3647; pfam12363 93061005618 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 93061005619 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 93061005620 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 93061005621 Phage capsid family; Region: Phage_capsid; pfam05065 93061005622 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 93061005623 phage putative head morphogenesis protein, SPP1 gp7 family; Region: phageSPP1_gp7; TIGR01641 93061005624 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 93061005625 phage terminase, large subunit, PBSX family; Region: phage_term_2; TIGR01547 93061005626 Terminase small subunit; Region: Terminase_2; pfam03592 93061005627 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 93061005628 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 93061005629 Transcriptional activator RinB; Region: RinB; pfam06116 93061005630 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 93061005631 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 93061005632 trimer interface [polypeptide binding]; other site 93061005633 active site 93061005634 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 93061005635 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 93061005636 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 93061005637 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 93061005638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93061005639 non-specific DNA binding site [nucleotide binding]; other site 93061005640 salt bridge; other site 93061005641 sequence-specific DNA binding site [nucleotide binding]; other site 93061005642 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 93061005643 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 93061005644 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 93061005645 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 93061005646 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 93061005647 Walker A motif; other site 93061005648 ATP binding site [chemical binding]; other site 93061005649 Walker B motif; other site 93061005650 DNA binding loops [nucleotide binding] 93061005651 N-terminal phage replisome organizer (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 93061005652 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 93061005653 Protein of unknown function (DUF968); Region: DUF968; pfam06147 93061005654 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 93061005655 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 93061005656 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 93061005657 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 93061005658 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 93061005659 BRO family, N-terminal domain; Region: Bro-N; smart01040 93061005660 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 93061005661 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93061005662 non-specific DNA binding site [nucleotide binding]; other site 93061005663 salt bridge; other site 93061005664 sequence-specific DNA binding site [nucleotide binding]; other site 93061005665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93061005666 non-specific DNA binding site [nucleotide binding]; other site 93061005667 salt bridge; other site 93061005668 sequence-specific DNA binding site [nucleotide binding]; other site 93061005669 Predicted transcriptional regulator [Transcription]; Region: COG2932 93061005670 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 93061005671 Catalytic site [active] 93061005672 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322 93061005673 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 93061005674 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 93061005675 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 93061005676 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 93061005677 active site 93061005678 DNA binding site [nucleotide binding] 93061005679 Int/Topo IB signature motif; other site 93061005680 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 93061005681 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93061005682 FeS/SAM binding site; other site 93061005683 YfkB-like domain; Region: YfkB; pfam08756 93061005684 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 93061005685 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 93061005686 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 93061005687 Low molecular weight phosphatase family; Region: LMWPc; cd00115 93061005688 active site 93061005689 YtxH-like protein; Region: YtxH; pfam12732 93061005690 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 93061005691 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 93061005692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061005693 active site 93061005694 phosphorylation site [posttranslational modification] 93061005695 intermolecular recognition site; other site 93061005696 dimerization interface [polypeptide binding]; other site 93061005697 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 93061005698 DNA binding residues [nucleotide binding] 93061005699 dimerization interface [polypeptide binding]; other site 93061005700 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 93061005701 Histidine kinase; Region: HisKA_3; pfam07730 93061005702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061005703 ATP binding site [chemical binding]; other site 93061005704 Mg2+ binding site [ion binding]; other site 93061005705 G-X-G motif; other site 93061005706 Predicted membrane protein [Function unknown]; Region: COG4758 93061005707 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 93061005708 active site 93061005709 Predicted membrane protein [Function unknown]; Region: COG4129 93061005710 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 93061005711 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 93061005712 catalytic triad [active] 93061005713 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 93061005714 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 93061005715 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 93061005716 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 93061005717 Ferritin-like domain; Region: Ferritin; pfam00210 93061005718 ferroxidase diiron center [ion binding]; other site 93061005719 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 93061005720 active site 93061005721 catalytic site [active] 93061005722 substrate binding site [chemical binding]; other site 93061005723 DNA polymerase IV; Validated; Region: PRK02406 93061005724 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 93061005725 active site 93061005726 DNA binding site [nucleotide binding] 93061005727 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 93061005728 TRAM domain; Region: TRAM; cl01282 93061005729 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 93061005730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061005731 S-adenosylmethionine binding site [chemical binding]; other site 93061005732 putative lipid kinase; Reviewed; Region: PRK13337 93061005733 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 93061005734 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 93061005735 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 93061005736 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 93061005737 GatB domain; Region: GatB_Yqey; pfam02637 93061005738 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 93061005739 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 93061005740 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 93061005741 Na binding site [ion binding]; other site 93061005742 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 93061005743 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 93061005744 putative dimer interface [polypeptide binding]; other site 93061005745 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 93061005746 putative dimer interface [polypeptide binding]; other site 93061005747 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 93061005748 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 93061005749 nucleotide binding pocket [chemical binding]; other site 93061005750 K-X-D-G motif; other site 93061005751 catalytic site [active] 93061005752 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 93061005753 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 93061005754 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 93061005755 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 93061005756 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 93061005757 Dimer interface [polypeptide binding]; other site 93061005758 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 93061005759 Part of AAA domain; Region: AAA_19; pfam13245 93061005760 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 93061005761 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 93061005762 substrate binding site [chemical binding]; other site 93061005763 putative active site [active] 93061005764 dimer interface [polypeptide binding]; other site 93061005765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 93061005766 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 93061005767 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 93061005768 tetramer interface [polypeptide binding]; other site 93061005769 active site 93061005770 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 93061005771 Staphopain proregion; Region: Staphopain_pro; pfam14731 93061005772 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 93061005773 Staphostatin A; Region: Staphostatin_A; pfam09022 93061005774 NETI protein; Region: NETI; pfam14044 93061005775 hypothetical protein; Provisional; Region: PRK04164 93061005776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 93061005777 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 93061005778 homodimer interface [polypeptide binding]; other site 93061005779 NAD binding pocket [chemical binding]; other site 93061005780 ATP binding pocket [chemical binding]; other site 93061005781 Mg binding site [ion binding]; other site 93061005782 active-site loop [active] 93061005783 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 93061005784 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 93061005785 active site 93061005786 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 93061005787 active site 93061005788 dimer interface [polypeptide binding]; other site 93061005789 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 93061005790 Prephenate dehydratase; Region: PDT; pfam00800 93061005791 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 93061005792 putative L-Phe binding site [chemical binding]; other site 93061005793 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 93061005794 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 93061005795 transmembrane helices; other site 93061005796 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 93061005797 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 93061005798 catalytic triad [active] 93061005799 conserved cis-peptide bond; other site 93061005800 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 93061005801 DHH family; Region: DHH; pfam01368 93061005802 DHHA2 domain; Region: DHHA2; pfam02833 93061005803 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 93061005804 NAD(P) binding site [chemical binding]; other site 93061005805 catalytic residues [active] 93061005806 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 93061005807 YolD-like protein; Region: YolD; pfam08863 93061005808 Predicted choloylglycine hydrolase [General function prediction only]; Region: COG4927 93061005809 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 93061005810 active site 93061005811 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 93061005812 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 93061005813 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 93061005814 Bacterial PH domain; Region: bPH_2; cl01348 93061005815 Thioredoxin; Region: Thioredoxin_9; pfam14595 93061005816 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 93061005817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061005818 Walker A/P-loop; other site 93061005819 ATP binding site [chemical binding]; other site 93061005820 Q-loop/lid; other site 93061005821 ABC transporter signature motif; other site 93061005822 Walker B; other site 93061005823 D-loop; other site 93061005824 H-loop/switch region; other site 93061005825 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 93061005826 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 93061005827 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 93061005828 Walker A/P-loop; other site 93061005829 ATP binding site [chemical binding]; other site 93061005830 Q-loop/lid; other site 93061005831 ABC transporter signature motif; other site 93061005832 Walker B; other site 93061005833 D-loop; other site 93061005834 H-loop/switch region; other site 93061005835 Predicted transcriptional regulators [Transcription]; Region: COG1725 93061005836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 93061005837 DNA-binding site [nucleotide binding]; DNA binding site 93061005838 hypothetical protein; Provisional; Region: PRK08637 93061005839 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93061005840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061005841 homodimer interface [polypeptide binding]; other site 93061005842 catalytic residue [active] 93061005843 MAP domain; Region: MAP; pfam03642 93061005844 superantigen-like protein 7; Reviewed; Region: PRK13346 93061005845 MAP domain; Region: MAP; pfam03642 93061005846 MAP domain; Region: MAP; pfam03642 93061005847 MAP domain; Region: MAP; pfam03642 93061005848 MAP domain; Region: MAP; pfam03642 93061005849 MAP domain; Region: MAP; pfam03642 93061005850 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 93061005851 chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032 93061005852 Bacterial SH3 domain homologues; Region: SH3b; smart00287 93061005853 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 93061005854 CHAP domain; Region: CHAP; pfam05257 93061005855 Small integral membrane protein [Function unknown]; Region: COG5546 93061005856 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 93061005857 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 93061005858 TolA protein; Region: tolA_full; TIGR02794 93061005859 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 93061005860 Phage tail protein; Region: Sipho_tail; cl17486 93061005861 Phage tail protein; Region: Sipho_tail; cl17486 93061005862 Phage-related minor tail protein [Function unknown]; Region: COG5280 93061005863 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 93061005864 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 93061005865 Domain of unknown function DUF20; Region: UPF0118; cl00465 93061005866 Phage-related protein [Function unknown]; Region: COG5412 93061005867 Peptidase family M23; Region: Peptidase_M23; pfam01551 93061005868 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 93061005869 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 93061005870 N-acetyl-D-glucosamine binding site [chemical binding]; other site 93061005871 catalytic residue [active] 93061005872 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 93061005873 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 93061005874 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 93061005875 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 93061005876 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 93061005877 oligomerization interface [polypeptide binding]; other site 93061005878 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 93061005879 glideosome-associated protein 45; Provisional; Region: PTZ00423 93061005880 Phage capsid family; Region: Phage_capsid; pfam05065 93061005881 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 93061005882 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 93061005883 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 93061005884 Phage Terminase; Region: Terminase_1; pfam03354 93061005885 Phage terminase, small subunit; Region: Terminase_4; pfam05119 93061005886 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 93061005887 active site 93061005888 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 93061005889 putative metal binding site [ion binding]; other site 93061005890 Transcriptional activator RinB; Region: RinB; pfam06116 93061005891 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 93061005892 dUTPase; Region: dUTPase_2; pfam08761 93061005893 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 93061005894 active site 93061005895 homodimer interface [polypeptide binding]; other site 93061005896 metal binding site [ion binding]; metal-binding site 93061005897 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 93061005898 YopX protein; Region: YopX; pfam09643 93061005899 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 93061005900 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 93061005901 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 93061005902 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 93061005903 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 93061005904 hypothetical protein; Validated; Region: PRK08116 93061005905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061005906 Walker A motif; other site 93061005907 ATP binding site [chemical binding]; other site 93061005908 Walker B motif; other site 93061005909 Helix-turn-helix domain; Region: HTH_36; pfam13730 93061005910 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 93061005911 Protein of unknown function (DUF968); Region: DUF968; pfam06147 93061005912 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 93061005913 Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656 93061005914 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 93061005915 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 93061005916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 93061005917 Protein of unknown function (DUF739); Region: DUF739; pfam05339 93061005918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93061005919 non-specific DNA binding site [nucleotide binding]; other site 93061005920 salt bridge; other site 93061005921 sequence-specific DNA binding site [nucleotide binding]; other site 93061005922 Predicted transcriptional regulator [Transcription]; Region: COG2932 93061005923 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 93061005924 Catalytic site [active] 93061005925 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 93061005926 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 93061005927 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 93061005928 Int/Topo IB signature motif; other site 93061005929 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 93061005930 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 93061005931 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 93061005932 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 93061005933 metal binding site [ion binding]; metal-binding site 93061005934 dimer interface [polypeptide binding]; other site 93061005935 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 93061005936 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 93061005937 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 93061005938 putative ligand binding residues [chemical binding]; other site 93061005939 Cation transport protein; Region: TrkH; cl17365 93061005940 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 93061005941 Cation transport protein; Region: TrkH; cl17365 93061005942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061005943 Coenzyme A binding pocket [chemical binding]; other site 93061005944 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 93061005945 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 93061005946 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 93061005947 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 93061005948 ring oligomerisation interface [polypeptide binding]; other site 93061005949 ATP/Mg binding site [chemical binding]; other site 93061005950 stacking interactions; other site 93061005951 hinge regions; other site 93061005952 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 93061005953 oligomerisation interface [polypeptide binding]; other site 93061005954 mobile loop; other site 93061005955 roof hairpin; other site 93061005956 CAAX protease self-immunity; Region: Abi; pfam02517 93061005957 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 93061005958 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 93061005959 dimer interface [polypeptide binding]; other site 93061005960 FMN binding site [chemical binding]; other site 93061005961 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 93061005962 putative active site [active] 93061005963 catalytic triad [active] 93061005964 putative dimer interface [polypeptide binding]; other site 93061005965 delta-hemolysin; Provisional; Region: PRK14752 93061005966 Accessory gene regulator B; Region: AgrB; smart00793 93061005967 Staphylococcal AgrD protein; Region: AgrD; pfam05931 93061005968 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 93061005969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061005970 Mg2+ binding site [ion binding]; other site 93061005971 G-X-G motif; other site 93061005972 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 93061005973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061005974 active site 93061005975 phosphorylation site [posttranslational modification] 93061005976 intermolecular recognition site; other site 93061005977 dimerization interface [polypeptide binding]; other site 93061005978 LytTr DNA-binding domain; Region: LytTR; pfam04397 93061005979 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 93061005980 putative substrate binding site [chemical binding]; other site 93061005981 putative ATP binding site [chemical binding]; other site 93061005982 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 93061005983 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 93061005984 substrate binding [chemical binding]; other site 93061005985 active site 93061005986 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 93061005987 Transcriptional regulators [Transcription]; Region: PurR; COG1609 93061005988 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 93061005989 DNA binding site [nucleotide binding] 93061005990 domain linker motif; other site 93061005991 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 93061005992 dimerization interface [polypeptide binding]; other site 93061005993 ligand binding site [chemical binding]; other site 93061005994 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 93061005995 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 93061005996 CPxP motif; other site 93061005997 Predicted transporter component [General function prediction only]; Region: COG2391 93061005998 Sulphur transport; Region: Sulf_transp; cl19477 93061005999 Sulphur transport; Region: Sulf_transp; cl19477 93061006000 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 93061006001 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 93061006002 CoA binding domain; Region: CoA_binding; pfam02629 93061006003 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 93061006004 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 93061006005 ABC transporter; Region: ABC_tran_2; pfam12848 93061006006 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 93061006007 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 93061006008 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 93061006009 Walker A/P-loop; other site 93061006010 ATP binding site [chemical binding]; other site 93061006011 Q-loop/lid; other site 93061006012 ABC transporter signature motif; other site 93061006013 Walker B; other site 93061006014 D-loop; other site 93061006015 H-loop/switch region; other site 93061006016 UGMP family protein; Validated; Region: PRK09604 93061006017 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 93061006018 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 93061006019 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 93061006020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061006021 Coenzyme A binding pocket [chemical binding]; other site 93061006022 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 93061006023 Glycoprotease family; Region: Peptidase_M22; pfam00814 93061006024 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 93061006025 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 93061006026 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 93061006027 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 93061006028 PYR/PP interface [polypeptide binding]; other site 93061006029 dimer interface [polypeptide binding]; other site 93061006030 TPP binding site [chemical binding]; other site 93061006031 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 93061006032 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 93061006033 TPP-binding site [chemical binding]; other site 93061006034 dimer interface [polypeptide binding]; other site 93061006035 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 93061006036 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 93061006037 ketol-acid reductoisomerase; Provisional; Region: PRK05479 93061006038 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 93061006039 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 93061006040 2-isopropylmalate synthase; Validated; Region: PRK00915 93061006041 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 93061006042 active site 93061006043 catalytic residues [active] 93061006044 metal binding site [ion binding]; metal-binding site 93061006045 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502 93061006046 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 93061006047 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 93061006048 substrate binding site [chemical binding]; other site 93061006049 ligand binding site [chemical binding]; other site 93061006050 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 93061006051 substrate binding site [chemical binding]; other site 93061006052 threonine dehydratase; Validated; Region: PRK08639 93061006053 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 93061006054 tetramer interface [polypeptide binding]; other site 93061006055 catalytic residue [active] 93061006056 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 93061006057 putative Ile/Val binding site [chemical binding]; other site 93061006058 hypothetical protein; Provisional; Region: PRK04351 93061006059 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 93061006060 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 93061006061 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 93061006062 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 93061006063 Death-like domain of SPT6; Region: DLD; pfam14878 93061006064 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 93061006065 RNA binding site [nucleotide binding]; other site 93061006066 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 93061006067 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 93061006068 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 93061006069 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 93061006070 DNA binding residues [nucleotide binding] 93061006071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061006072 ATP binding site [chemical binding]; other site 93061006073 Mg2+ binding site [ion binding]; other site 93061006074 G-X-G motif; other site 93061006075 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 93061006076 anti sigma factor interaction site; other site 93061006077 regulatory phosphorylation site [posttranslational modification]; other site 93061006078 PemK-like protein; Region: PemK; pfam02452 93061006079 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 93061006080 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 93061006081 active site 93061006082 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 93061006083 dimer interface [polypeptide binding]; other site 93061006084 substrate binding site [chemical binding]; other site 93061006085 catalytic residues [active] 93061006086 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 93061006087 Uncharacterized conserved protein [Function unknown]; Region: COG3402 93061006088 Predicted membrane protein [Function unknown]; Region: COG3428 93061006089 Bacterial PH domain; Region: bPH_2; pfam03703 93061006090 Bacterial PH domain; Region: bPH_2; pfam03703 93061006091 Bacterial PH domain; Region: bPH_2; cl01348 93061006092 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 93061006093 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 93061006094 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 93061006095 Soluble P-type ATPase [General function prediction only]; Region: COG4087 93061006096 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 93061006097 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 93061006098 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 93061006099 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 93061006100 Ligand Binding Site [chemical binding]; other site 93061006101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061006102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 93061006103 dimer interface [polypeptide binding]; other site 93061006104 phosphorylation site [posttranslational modification] 93061006105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061006106 ATP binding site [chemical binding]; other site 93061006107 Mg2+ binding site [ion binding]; other site 93061006108 G-X-G motif; other site 93061006109 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 93061006110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061006111 active site 93061006112 phosphorylation site [posttranslational modification] 93061006113 intermolecular recognition site; other site 93061006114 dimerization interface [polypeptide binding]; other site 93061006115 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93061006116 DNA binding site [nucleotide binding] 93061006117 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 93061006118 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 93061006119 ATP binding site [chemical binding]; other site 93061006120 Mg++ binding site [ion binding]; other site 93061006121 motif III; other site 93061006122 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93061006123 nucleotide binding region [chemical binding]; other site 93061006124 ATP-binding site [chemical binding]; other site 93061006125 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 93061006126 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 93061006127 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 93061006128 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 93061006129 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 93061006130 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 93061006131 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 93061006132 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 93061006133 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 93061006134 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 93061006135 putative homodimer interface [polypeptide binding]; other site 93061006136 putative homotetramer interface [polypeptide binding]; other site 93061006137 allosteric switch controlling residues; other site 93061006138 putative metal binding site [ion binding]; other site 93061006139 putative homodimer-homodimer interface [polypeptide binding]; other site 93061006140 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 93061006141 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 93061006142 putative active site [active] 93061006143 catalytic site [active] 93061006144 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 93061006145 putative active site [active] 93061006146 catalytic site [active] 93061006147 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 93061006148 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 93061006149 Zn2+ binding site [ion binding]; other site 93061006150 Mg2+ binding site [ion binding]; other site 93061006151 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 93061006152 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 93061006153 thiamine phosphate binding site [chemical binding]; other site 93061006154 active site 93061006155 pyrophosphate binding site [ion binding]; other site 93061006156 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 93061006157 substrate binding site [chemical binding]; other site 93061006158 multimerization interface [polypeptide binding]; other site 93061006159 ATP binding site [chemical binding]; other site 93061006160 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 93061006161 dimer interface [polypeptide binding]; other site 93061006162 substrate binding site [chemical binding]; other site 93061006163 ATP binding site [chemical binding]; other site 93061006164 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 93061006165 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 93061006166 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 93061006167 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 93061006168 dimer interface [polypeptide binding]; other site 93061006169 ssDNA binding site [nucleotide binding]; other site 93061006170 tetramer (dimer of dimers) interface [polypeptide binding]; other site 93061006171 YwpF-like protein; Region: YwpF; pfam14183 93061006172 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 93061006173 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 93061006174 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 93061006175 hinge; other site 93061006176 active site 93061006177 Predicted membrane protein [Function unknown]; Region: COG4836 93061006178 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 93061006179 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 93061006180 gamma subunit interface [polypeptide binding]; other site 93061006181 epsilon subunit interface [polypeptide binding]; other site 93061006182 LBP interface [polypeptide binding]; other site 93061006183 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 93061006184 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 93061006185 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 93061006186 alpha subunit interaction interface [polypeptide binding]; other site 93061006187 Walker A motif; other site 93061006188 ATP binding site [chemical binding]; other site 93061006189 Walker B motif; other site 93061006190 inhibitor binding site; inhibition site 93061006191 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 93061006192 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 93061006193 core domain interface [polypeptide binding]; other site 93061006194 delta subunit interface [polypeptide binding]; other site 93061006195 epsilon subunit interface [polypeptide binding]; other site 93061006196 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 93061006197 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 93061006198 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 93061006199 beta subunit interaction interface [polypeptide binding]; other site 93061006200 Walker A motif; other site 93061006201 ATP binding site [chemical binding]; other site 93061006202 Walker B motif; other site 93061006203 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 93061006204 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 93061006205 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 93061006206 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 93061006207 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 93061006208 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 93061006209 ATP synthase I chain; Region: ATP_synt_I; pfam03899 93061006210 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 93061006211 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 93061006212 active site 93061006213 homodimer interface [polypeptide binding]; other site 93061006214 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93061006215 active site 93061006216 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 93061006217 dimer interface [polypeptide binding]; other site 93061006218 active site 93061006219 glycine-pyridoxal phosphate binding site [chemical binding]; other site 93061006220 folate binding site [chemical binding]; other site 93061006221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4475 93061006222 Low molecular weight phosphatase family; Region: LMWPc; cd00115 93061006223 active site 93061006224 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 93061006225 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 93061006226 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 93061006227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061006228 S-adenosylmethionine binding site [chemical binding]; other site 93061006229 peptide chain release factor 1; Validated; Region: prfA; PRK00591 93061006230 This domain is found in peptide chain release factors; Region: PCRF; smart00937 93061006231 RF-1 domain; Region: RF-1; pfam00472 93061006232 thymidine kinase; Provisional; Region: PRK04296 93061006233 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 93061006234 transcription termination factor Rho; Provisional; Region: rho; PRK09376 93061006235 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 93061006236 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 93061006237 RNA binding site [nucleotide binding]; other site 93061006238 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 93061006239 Walker A motif; other site 93061006240 ATP binding site [chemical binding]; other site 93061006241 Walker B motif; other site 93061006242 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 93061006243 NAD binding site [chemical binding]; other site 93061006244 catalytic residues [active] 93061006245 Predicted transcriptional regulators [Transcription]; Region: COG1733 93061006246 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 93061006247 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 93061006248 hinge; other site 93061006249 active site 93061006250 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 93061006251 intersubunit interface [polypeptide binding]; other site 93061006252 active site 93061006253 zinc binding site [ion binding]; other site 93061006254 Na+ binding site [ion binding]; other site 93061006255 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 93061006256 CTP synthetase; Validated; Region: pyrG; PRK05380 93061006257 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 93061006258 Catalytic site [active] 93061006259 active site 93061006260 UTP binding site [chemical binding]; other site 93061006261 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 93061006262 active site 93061006263 putative oxyanion hole; other site 93061006264 catalytic triad [active] 93061006265 DNA-directed RNA polymerase, delta subunit [Transcription]; Region: RpoE; COG3343 93061006266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061006267 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 93061006268 Coenzyme A binding pocket [chemical binding]; other site 93061006269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061006270 Coenzyme A binding pocket [chemical binding]; other site 93061006271 pantothenate kinase; Provisional; Region: PRK13317 93061006272 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 93061006273 ATP-grasp domain; Region: ATP-grasp_4; cl17255 93061006274 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 93061006275 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 93061006276 metal binding site [ion binding]; metal-binding site 93061006277 S-ribosylhomocysteinase; Provisional; Region: PRK02260 93061006278 Predicted membrane protein [Function unknown]; Region: COG4270 93061006279 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 93061006280 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 93061006281 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 93061006282 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 93061006283 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 93061006284 intersubunit interface [polypeptide binding]; other site 93061006285 active site 93061006286 catalytic residue [active] 93061006287 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 93061006288 Ferritin-like domain; Region: Ferritin; pfam00210 93061006289 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 93061006290 dimerization interface [polypeptide binding]; other site 93061006291 DPS ferroxidase diiron center [ion binding]; other site 93061006292 ion pore; other site 93061006293 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 93061006294 EVE domain; Region: EVE; pfam01878 93061006295 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 93061006296 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 93061006297 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 93061006298 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 93061006299 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 93061006300 NAD(P) binding site [chemical binding]; other site 93061006301 putative active site [active] 93061006302 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 93061006303 dimerization interface [polypeptide binding]; other site 93061006304 putative DNA binding site [nucleotide binding]; other site 93061006305 putative Zn2+ binding site [ion binding]; other site 93061006306 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 93061006307 SAP domain; Region: SAP; pfam02037 93061006308 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 93061006309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061006310 active site 93061006311 motif I; other site 93061006312 motif II; other site 93061006313 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 93061006314 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 93061006315 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 93061006316 Walker A/P-loop; other site 93061006317 ATP binding site [chemical binding]; other site 93061006318 Q-loop/lid; other site 93061006319 ABC transporter signature motif; other site 93061006320 Walker B; other site 93061006321 D-loop; other site 93061006322 H-loop/switch region; other site 93061006323 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 93061006324 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 93061006325 glutaminase active site [active] 93061006326 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 93061006327 dimer interface [polypeptide binding]; other site 93061006328 active site 93061006329 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 93061006330 dimer interface [polypeptide binding]; other site 93061006331 active site 93061006332 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 93061006333 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 93061006334 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 93061006335 active site 93061006336 P-loop; other site 93061006337 phosphorylation site [posttranslational modification] 93061006338 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 93061006339 HTH domain; Region: HTH_11; cl17392 93061006340 Mga helix-turn-helix domain; Region: Mga; pfam05043 93061006341 PRD domain; Region: PRD; pfam00874 93061006342 PRD domain; Region: PRD; pfam00874 93061006343 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 93061006344 active site 93061006345 P-loop; other site 93061006346 phosphorylation site [posttranslational modification] 93061006347 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 93061006348 active site 93061006349 phosphorylation site [posttranslational modification] 93061006350 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 93061006351 active site 93061006352 phosphorylation site [posttranslational modification] 93061006353 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 93061006354 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 93061006355 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 93061006356 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 93061006357 Proline-rich; Region: Pro-rich; pfam15240 93061006358 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 93061006359 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006360 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006361 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006362 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006363 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006364 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006365 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006366 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006367 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006368 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006369 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006370 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006371 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006372 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006373 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 93061006374 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 93061006375 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 93061006376 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 93061006377 active site 93061006378 substrate binding site [chemical binding]; other site 93061006379 metal binding site [ion binding]; metal-binding site 93061006380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 93061006381 YbbR-like protein; Region: YbbR; pfam07949 93061006382 YbbR-like protein; Region: YbbR; pfam07949 93061006383 Uncharacterized conserved protein [Function unknown]; Region: COG1624 93061006384 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 93061006385 Arginase family; Region: Arginase; cd09989 93061006386 active site 93061006387 Mn binding site [ion binding]; other site 93061006388 oligomer interface [polypeptide binding]; other site 93061006389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061006390 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061006391 putative substrate translocation pore; other site 93061006392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061006393 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061006394 putative substrate translocation pore; other site 93061006395 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 93061006396 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 93061006397 substrate binding site; other site 93061006398 dimerization interface; other site 93061006399 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 93061006400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 93061006401 Nucleoside recognition; Region: Gate; pfam07670 93061006402 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 93061006403 ABC-ATPase subunit interface; other site 93061006404 dimer interface [polypeptide binding]; other site 93061006405 putative PBP binding regions; other site 93061006406 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 93061006407 ABC-ATPase subunit interface; other site 93061006408 dimer interface [polypeptide binding]; other site 93061006409 putative PBP binding regions; other site 93061006410 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 93061006411 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 93061006412 siderophore binding site; other site 93061006413 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 93061006414 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 93061006415 dimer interface [polypeptide binding]; other site 93061006416 active site 93061006417 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 93061006418 substrate binding site [chemical binding]; other site 93061006419 catalytic residue [active] 93061006420 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 93061006421 IucA / IucC family; Region: IucA_IucC; pfam04183 93061006422 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 93061006423 H+ Antiporter protein; Region: 2A0121; TIGR00900 93061006424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061006425 putative substrate translocation pore; other site 93061006426 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 93061006427 IucA / IucC family; Region: IucA_IucC; pfam04183 93061006428 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 93061006429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 93061006430 Small integral membrane protein [Function unknown]; Region: COG5547 93061006431 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 93061006432 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 93061006433 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 93061006434 putative NAD(P) binding site [chemical binding]; other site 93061006435 dimer interface [polypeptide binding]; other site 93061006436 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 93061006437 Prostaglandin dehydrogenases; Region: PGDH; cd05288 93061006438 NAD(P) binding site [chemical binding]; other site 93061006439 substrate binding site [chemical binding]; other site 93061006440 dimer interface [polypeptide binding]; other site 93061006441 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 93061006442 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 93061006443 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 93061006444 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 93061006445 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 93061006446 active site 93061006447 P-loop; other site 93061006448 phosphorylation site [posttranslational modification] 93061006449 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 93061006450 methionine cluster; other site 93061006451 active site 93061006452 phosphorylation site [posttranslational modification] 93061006453 metal binding site [ion binding]; metal-binding site 93061006454 tagatose 1,6-diphosphate aldolase; Region: lacD; TIGR01232 93061006455 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 93061006456 putative substrate binding site [chemical binding]; other site 93061006457 putative ATP binding site [chemical binding]; other site 93061006458 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 93061006459 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 93061006460 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 93061006461 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 93061006462 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 93061006463 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 93061006464 NAD+ binding site [chemical binding]; other site 93061006465 substrate binding site [chemical binding]; other site 93061006466 putative Zn binding site [ion binding]; other site 93061006467 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 93061006468 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 93061006469 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 93061006470 active site 93061006471 catalytic tetrad [active] 93061006472 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 93061006473 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 93061006474 DNA binding residues [nucleotide binding] 93061006475 putative dimer interface [polypeptide binding]; other site 93061006476 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 93061006477 substrate binding site [chemical binding]; other site 93061006478 catalytic residues [active] 93061006479 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 93061006480 Peptidase family M23; Region: Peptidase_M23; pfam01551 93061006481 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 93061006482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061006483 active site 93061006484 motif I; other site 93061006485 motif II; other site 93061006486 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 93061006487 acetolactate synthase; Reviewed; Region: PRK08617 93061006488 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 93061006489 PYR/PP interface [polypeptide binding]; other site 93061006490 dimer interface [polypeptide binding]; other site 93061006491 TPP binding site [chemical binding]; other site 93061006492 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 93061006493 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 93061006494 TPP-binding site [chemical binding]; other site 93061006495 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 93061006496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061006497 Walker A motif; other site 93061006498 ATP binding site [chemical binding]; other site 93061006499 Walker B motif; other site 93061006500 arginine finger; other site 93061006501 Predicted helicase [General function prediction only]; Region: COG4889 93061006502 Predicted helicase [General function prediction only]; Region: COG4889 93061006503 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 93061006504 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 93061006505 23S rRNA interface [nucleotide binding]; other site 93061006506 L3 interface [polypeptide binding]; other site 93061006507 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 93061006508 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 93061006509 dimerization interface 3.5A [polypeptide binding]; other site 93061006510 active site 93061006511 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 93061006512 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 93061006513 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 93061006514 Walker A/P-loop; other site 93061006515 ATP binding site [chemical binding]; other site 93061006516 Q-loop/lid; other site 93061006517 ABC transporter signature motif; other site 93061006518 Walker B; other site 93061006519 D-loop; other site 93061006520 H-loop/switch region; other site 93061006521 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 93061006522 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 93061006523 Walker A/P-loop; other site 93061006524 ATP binding site [chemical binding]; other site 93061006525 Q-loop/lid; other site 93061006526 ABC transporter signature motif; other site 93061006527 Walker B; other site 93061006528 D-loop; other site 93061006529 H-loop/switch region; other site 93061006530 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 93061006531 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 93061006532 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 93061006533 alphaNTD homodimer interface [polypeptide binding]; other site 93061006534 alphaNTD - beta interaction site [polypeptide binding]; other site 93061006535 alphaNTD - beta' interaction site [polypeptide binding]; other site 93061006536 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 93061006537 30S ribosomal protein S11; Validated; Region: PRK05309 93061006538 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 93061006539 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 93061006540 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 93061006541 rRNA binding site [nucleotide binding]; other site 93061006542 predicted 30S ribosome binding site; other site 93061006543 adenylate kinase; Reviewed; Region: adk; PRK00279 93061006544 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 93061006545 AMP-binding site [chemical binding]; other site 93061006546 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 93061006547 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 93061006548 SecY translocase; Region: SecY; pfam00344 93061006549 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 93061006550 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 93061006551 23S rRNA binding site [nucleotide binding]; other site 93061006552 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 93061006553 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 93061006554 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 93061006555 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 93061006556 5S rRNA interface [nucleotide binding]; other site 93061006557 L27 interface [polypeptide binding]; other site 93061006558 23S rRNA interface [nucleotide binding]; other site 93061006559 L5 interface [polypeptide binding]; other site 93061006560 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 93061006561 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 93061006562 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 93061006563 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 93061006564 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 93061006565 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 93061006566 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 93061006567 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 93061006568 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 93061006569 RNA binding site [nucleotide binding]; other site 93061006570 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 93061006571 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 93061006572 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 93061006573 23S rRNA interface [nucleotide binding]; other site 93061006574 putative translocon interaction site; other site 93061006575 signal recognition particle (SRP54) interaction site; other site 93061006576 L23 interface [polypeptide binding]; other site 93061006577 trigger factor interaction site; other site 93061006578 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 93061006579 23S rRNA interface [nucleotide binding]; other site 93061006580 5S rRNA interface [nucleotide binding]; other site 93061006581 putative antibiotic binding site [chemical binding]; other site 93061006582 L25 interface [polypeptide binding]; other site 93061006583 L27 interface [polypeptide binding]; other site 93061006584 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 93061006585 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 93061006586 G-X-X-G motif; other site 93061006587 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 93061006588 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 93061006589 putative translocon binding site; other site 93061006590 protein-rRNA interface [nucleotide binding]; other site 93061006591 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 93061006592 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 93061006593 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 93061006594 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 93061006595 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 93061006596 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 93061006597 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 93061006598 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 93061006599 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 93061006600 Sulfate transporter family; Region: Sulfate_transp; cl19250 93061006601 DNA topoisomerase III; Provisional; Region: PRK07726 93061006602 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 93061006603 active site 93061006604 putative interdomain interaction site [polypeptide binding]; other site 93061006605 putative metal-binding site [ion binding]; other site 93061006606 putative nucleotide binding site [chemical binding]; other site 93061006607 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 93061006608 domain I; other site 93061006609 DNA binding groove [nucleotide binding] 93061006610 phosphate binding site [ion binding]; other site 93061006611 domain II; other site 93061006612 domain III; other site 93061006613 nucleotide binding site [chemical binding]; other site 93061006614 catalytic site [active] 93061006615 domain IV; other site 93061006616 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 93061006617 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 93061006618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061006619 Coenzyme A binding pocket [chemical binding]; other site 93061006620 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 93061006621 Sugar transport protein; Region: Sugar_transport; pfam06800 93061006622 Predicted permeases [General function prediction only]; Region: COG0679 93061006623 Striatin family; Region: Striatin; pfam08232 93061006624 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 93061006625 MMPL family; Region: MMPL; cl14618 93061006626 MMPL family; Region: MMPL; cl14618 93061006627 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 93061006628 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 93061006629 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061006630 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 93061006631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061006632 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061006633 putative substrate translocation pore; other site 93061006634 MarR family; Region: MarR_2; cl17246 93061006635 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061006636 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 93061006637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93061006638 FeS/SAM binding site; other site 93061006639 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 93061006640 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 93061006641 GTP binding site; other site 93061006642 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 93061006643 MoaE interaction surface [polypeptide binding]; other site 93061006644 MoeB interaction surface [polypeptide binding]; other site 93061006645 thiocarboxylated glycine; other site 93061006646 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 93061006647 MoaE homodimer interface [polypeptide binding]; other site 93061006648 MoaD interaction [polypeptide binding]; other site 93061006649 active site residues [active] 93061006650 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 93061006651 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 93061006652 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 93061006653 dimer interface [polypeptide binding]; other site 93061006654 putative functional site; other site 93061006655 putative MPT binding site; other site 93061006656 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 93061006657 trimer interface [polypeptide binding]; other site 93061006658 dimer interface [polypeptide binding]; other site 93061006659 putative active site [active] 93061006660 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 93061006661 MPT binding site; other site 93061006662 trimer interface [polypeptide binding]; other site 93061006663 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 93061006664 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 93061006665 ATP binding site [chemical binding]; other site 93061006666 substrate interface [chemical binding]; other site 93061006667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061006668 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 93061006669 Walker A/P-loop; other site 93061006670 ATP binding site [chemical binding]; other site 93061006671 Q-loop/lid; other site 93061006672 ABC transporter signature motif; other site 93061006673 Walker B; other site 93061006674 D-loop; other site 93061006675 H-loop/switch region; other site 93061006676 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 93061006677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061006678 dimer interface [polypeptide binding]; other site 93061006679 conserved gate region; other site 93061006680 putative PBP binding loops; other site 93061006681 ABC-ATPase subunit interface; other site 93061006682 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 93061006683 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 93061006684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061006685 Coenzyme A binding pocket [chemical binding]; other site 93061006686 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 93061006687 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 93061006688 active site 93061006689 dimerization interface [polypeptide binding]; other site 93061006690 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 93061006691 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 93061006692 intersubunit interface [polypeptide binding]; other site 93061006693 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 93061006694 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 93061006695 alpha-gamma subunit interface [polypeptide binding]; other site 93061006696 beta-gamma subunit interface [polypeptide binding]; other site 93061006697 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 93061006698 gamma-beta subunit interface [polypeptide binding]; other site 93061006699 alpha-beta subunit interface [polypeptide binding]; other site 93061006700 urease subunit alpha; Reviewed; Region: ureC; PRK13207 93061006701 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 93061006702 subunit interactions [polypeptide binding]; other site 93061006703 active site 93061006704 flap region; other site 93061006705 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 93061006706 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 93061006707 dimer interface [polypeptide binding]; other site 93061006708 catalytic residues [active] 93061006709 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 93061006710 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 93061006711 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 93061006712 MarR family; Region: MarR_2; cl17246 93061006713 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061006714 Bacterial PH domain; Region: bPH_3; pfam14470 93061006715 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 93061006716 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 93061006717 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061006718 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 93061006719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 93061006720 Surface antigen [General function prediction only]; Region: COG3942 93061006721 CHAP domain; Region: CHAP; pfam05257 93061006722 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 93061006723 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 93061006724 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 93061006725 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 93061006726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 93061006727 Surface antigen [General function prediction only]; Region: COG3942 93061006728 CHAP domain; Region: CHAP; pfam05257 93061006729 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 93061006730 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 93061006731 putative ligand binding site [chemical binding]; other site 93061006732 putative NAD binding site [chemical binding]; other site 93061006733 catalytic site [active] 93061006734 hypothetical protein; Provisional; Region: PRK06753 93061006735 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 93061006736 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 93061006737 Lysozyme subfamily 2; Region: LYZ2; smart00047 93061006738 Uncharacterized conserved protein [Function unknown]; Region: COG2427 93061006739 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 93061006740 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 93061006741 catalytic loop [active] 93061006742 iron binding site [ion binding]; other site 93061006743 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 93061006744 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 93061006745 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 93061006746 [4Fe-4S] binding site [ion binding]; other site 93061006747 molybdopterin cofactor binding site; other site 93061006748 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 93061006749 molybdopterin cofactor binding site; other site 93061006750 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 93061006751 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 93061006752 active site 93061006753 Predicted transcriptional regulator [Transcription]; Region: COG2378 93061006754 HTH domain; Region: HTH_11; pfam08279 93061006755 CAAX protease self-immunity; Region: Abi; pfam02517 93061006756 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 93061006757 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 93061006758 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 93061006759 putative active site [active] 93061006760 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 93061006761 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 93061006762 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 93061006763 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061006764 active site 93061006765 motif I; other site 93061006766 motif II; other site 93061006767 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 93061006768 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 93061006769 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 93061006770 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 93061006771 active site turn [active] 93061006772 phosphorylation site [posttranslational modification] 93061006773 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 93061006774 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 93061006775 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 93061006776 putative active site [active] 93061006777 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 93061006778 putative hydrophobic ligand binding site [chemical binding]; other site 93061006779 oxidoreductase; Provisional; Region: PRK07985 93061006780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93061006781 NAD(P) binding site [chemical binding]; other site 93061006782 active site 93061006783 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 93061006784 amidohydrolase; Region: amidohydrolases; TIGR01891 93061006785 metal binding site [ion binding]; metal-binding site 93061006786 dimer interface [polypeptide binding]; other site 93061006787 imidazolonepropionase; Validated; Region: PRK09356 93061006788 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 93061006789 active site 93061006790 urocanate hydratase; Provisional; Region: PRK05414 93061006791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 93061006792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 93061006793 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 93061006794 dimerization interface [polypeptide binding]; other site 93061006795 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 93061006796 putative active site [active] 93061006797 putative Mg binding site [ion binding]; other site 93061006798 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 93061006799 putative active site [active] 93061006800 putative metal binding site [ion binding]; other site 93061006801 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 93061006802 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 93061006803 tetramer (dimer of dimers) interface [polypeptide binding]; other site 93061006804 active site 93061006805 dimer interface [polypeptide binding]; other site 93061006806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 93061006807 MOSC domain; Region: MOSC; pfam03473 93061006808 3-alpha domain; Region: 3-alpha; pfam03475 93061006809 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 93061006810 active site 93061006811 catalytic residues [active] 93061006812 Uncharacterized conserved protein [Function unknown]; Region: COG1742 93061006813 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 93061006814 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 93061006815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061006816 Walker A/P-loop; other site 93061006817 ATP binding site [chemical binding]; other site 93061006818 Q-loop/lid; other site 93061006819 ABC transporter signature motif; other site 93061006820 Walker B; other site 93061006821 D-loop; other site 93061006822 H-loop/switch region; other site 93061006823 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 93061006824 Predicted membrane protein [Function unknown]; Region: COG3152 93061006825 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 93061006826 active site 93061006827 DNA binding site [nucleotide binding] 93061006828 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 93061006829 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 93061006830 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 93061006831 homotetramer interface [polypeptide binding]; other site 93061006832 FMN binding site [chemical binding]; other site 93061006833 homodimer contacts [polypeptide binding]; other site 93061006834 putative active site [active] 93061006835 putative substrate binding site [chemical binding]; other site 93061006836 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 93061006837 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 93061006838 oligomer interface [polypeptide binding]; other site 93061006839 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 93061006840 active site 93061006841 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 93061006842 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 93061006843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061006844 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 93061006845 putative substrate translocation pore; other site 93061006846 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 93061006847 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 93061006848 HlyD family secretion protein; Region: HlyD_3; pfam13437 93061006849 lipoyl-biotinyl attachment site [posttranslational modification]; other site 93061006850 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 93061006851 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 93061006852 Predicted membrane protein [Function unknown]; Region: COG4640 93061006853 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 93061006854 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 93061006855 putative active site [active] 93061006856 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 93061006857 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 93061006858 Walker A/P-loop; other site 93061006859 ATP binding site [chemical binding]; other site 93061006860 Q-loop/lid; other site 93061006861 ABC transporter signature motif; other site 93061006862 Walker B; other site 93061006863 D-loop; other site 93061006864 H-loop/switch region; other site 93061006865 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 93061006866 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 93061006867 FtsX-like permease family; Region: FtsX; pfam02687 93061006868 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 93061006869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061006870 active site 93061006871 phosphorylation site [posttranslational modification] 93061006872 intermolecular recognition site; other site 93061006873 dimerization interface [polypeptide binding]; other site 93061006874 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93061006875 DNA binding site [nucleotide binding] 93061006876 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 93061006877 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 93061006878 dimerization interface [polypeptide binding]; other site 93061006879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 93061006880 dimer interface [polypeptide binding]; other site 93061006881 phosphorylation site [posttranslational modification] 93061006882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061006883 ATP binding site [chemical binding]; other site 93061006884 Mg2+ binding site [ion binding]; other site 93061006885 G-X-G motif; other site 93061006886 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 93061006887 LytTr DNA-binding domain; Region: LytTR; smart00850 93061006888 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 93061006889 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 93061006890 Predicted dehydrogenase [General function prediction only]; Region: COG0579 93061006891 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 93061006892 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 93061006893 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 93061006894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061006895 Coenzyme A binding pocket [chemical binding]; other site 93061006896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 93061006897 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 93061006898 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 93061006899 NAD(P) binding site [chemical binding]; other site 93061006900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061006901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 93061006902 Coenzyme A binding pocket [chemical binding]; other site 93061006903 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 93061006904 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 93061006905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93061006906 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 93061006907 Predicted membrane protein [Function unknown]; Region: COG1511 93061006908 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 93061006909 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 93061006910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 93061006911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 93061006912 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 93061006913 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 93061006914 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 93061006915 Cl binding site [ion binding]; other site 93061006916 oligomer interface [polypeptide binding]; other site 93061006917 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 93061006918 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 93061006919 active site turn [active] 93061006920 phosphorylation site [posttranslational modification] 93061006921 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 93061006922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 93061006923 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 93061006924 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 93061006925 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 93061006926 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 93061006927 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 93061006928 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 93061006929 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061006930 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 93061006931 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 93061006932 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 93061006933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061006934 putative substrate translocation pore; other site 93061006935 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 93061006936 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 93061006937 DNA binding residues [nucleotide binding] 93061006938 dimer interface [polypeptide binding]; other site 93061006939 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 93061006940 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 93061006941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061006942 active site 93061006943 phosphorylation site [posttranslational modification] 93061006944 intermolecular recognition site; other site 93061006945 dimerization interface [polypeptide binding]; other site 93061006946 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 93061006947 DNA binding residues [nucleotide binding] 93061006948 dimerization interface [polypeptide binding]; other site 93061006949 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 93061006950 Domain of unknown function (DUF334); Region: DUF334; pfam03904 93061006951 Histidine kinase; Region: HisKA_3; pfam07730 93061006952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061006953 ATP binding site [chemical binding]; other site 93061006954 Mg2+ binding site [ion binding]; other site 93061006955 G-X-G motif; other site 93061006956 GAF domain; Region: GAF_2; pfam13185 93061006957 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 93061006958 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 93061006959 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 93061006960 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 93061006961 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 93061006962 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 93061006963 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 93061006964 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 93061006965 [4Fe-4S] binding site [ion binding]; other site 93061006966 molybdopterin cofactor binding site [chemical binding]; other site 93061006967 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 93061006968 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 93061006969 molybdopterin cofactor binding site; other site 93061006970 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 93061006971 active site 93061006972 SAM binding site [chemical binding]; other site 93061006973 homodimer interface [polypeptide binding]; other site 93061006974 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 93061006975 [2Fe-2S] cluster binding site [ion binding]; other site 93061006976 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 93061006977 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 93061006978 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93061006979 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 93061006980 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 93061006981 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 93061006982 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 93061006983 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 93061006984 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 93061006985 putative active site [active] 93061006986 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 93061006987 active site 93061006988 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 93061006989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061006990 Coenzyme A binding pocket [chemical binding]; other site 93061006991 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 93061006992 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 93061006993 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 93061006994 putative hydrophobic ligand binding site [chemical binding]; other site 93061006995 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 93061006996 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 93061006997 intersubunit interface [polypeptide binding]; other site 93061006998 YodA lipocalin-like domain; Region: YodA; pfam09223 93061006999 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 93061007000 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 93061007001 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 93061007002 Thioredoxin; Region: Thioredoxin_4; pfam13462 93061007003 Domain of unknown function with cystatin-like fold (DUF4467); Region: DUF4467; pfam14729 93061007004 FemAB family; Region: FemAB; pfam02388 93061007005 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 93061007006 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 93061007007 Walker A/P-loop; other site 93061007008 ATP binding site [chemical binding]; other site 93061007009 Q-loop/lid; other site 93061007010 ABC transporter signature motif; other site 93061007011 Walker B; other site 93061007012 D-loop; other site 93061007013 H-loop/switch region; other site 93061007014 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 93061007015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061007016 dimer interface [polypeptide binding]; other site 93061007017 conserved gate region; other site 93061007018 putative PBP binding loops; other site 93061007019 ABC-ATPase subunit interface; other site 93061007020 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 93061007021 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 93061007022 substrate binding pocket [chemical binding]; other site 93061007023 membrane-bound complex binding site; other site 93061007024 hinge residues; other site 93061007025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061007026 putative substrate translocation pore; other site 93061007027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061007028 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 93061007029 catalytic core [active] 93061007030 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 93061007031 B domain; Region: B; pfam02216 93061007032 B domain; Region: B; pfam02216 93061007033 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 93061007034 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 93061007035 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 93061007036 beta-channel forming cytolysin; Region: hlyII; TIGR01002 93061007037 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 93061007038 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 93061007039 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 93061007040 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93061007041 catalytic residue [active] 93061007042 biotin synthase; Validated; Region: PRK06256 93061007043 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93061007044 FeS/SAM binding site; other site 93061007045 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 93061007046 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 93061007047 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 93061007048 inhibitor-cofactor binding pocket; inhibition site 93061007049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061007050 catalytic residue [active] 93061007051 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 93061007052 AAA domain; Region: AAA_26; pfam13500 93061007053 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 93061007054 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93061007055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061007056 Walker A/P-loop; other site 93061007057 ATP binding site [chemical binding]; other site 93061007058 Q-loop/lid; other site 93061007059 ABC transporter signature motif; other site 93061007060 Walker B; other site 93061007061 D-loop; other site 93061007062 H-loop/switch region; other site 93061007063 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 93061007064 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93061007065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061007066 Walker A/P-loop; other site 93061007067 ATP binding site [chemical binding]; other site 93061007068 Q-loop/lid; other site 93061007069 ABC transporter signature motif; other site 93061007070 Walker B; other site 93061007071 D-loop; other site 93061007072 H-loop/switch region; other site 93061007073 GtrA-like protein; Region: GtrA; pfam04138 93061007074 glycerate kinase; Region: TIGR00045 93061007075 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 93061007076 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 93061007077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061007078 putative substrate translocation pore; other site 93061007079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 93061007080 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 93061007081 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 93061007082 putative phosphoesterase; Region: acc_ester; TIGR03729 93061007083 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 93061007084 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 93061007085 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 93061007086 Amino acid permease; Region: AA_permease_2; pfam13520 93061007087 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 93061007088 Beta-lactamase; Region: Beta-lactamase; pfam00144 93061007089 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93061007090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93061007091 NAD(P) binding site [chemical binding]; other site 93061007092 active site 93061007093 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 93061007094 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 93061007095 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 93061007096 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061007097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061007098 putative substrate translocation pore; other site 93061007099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061007100 dimer interface [polypeptide binding]; other site 93061007101 conserved gate region; other site 93061007102 putative PBP binding loops; other site 93061007103 ABC-ATPase subunit interface; other site 93061007104 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 93061007105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061007106 dimer interface [polypeptide binding]; other site 93061007107 conserved gate region; other site 93061007108 putative PBP binding loops; other site 93061007109 ABC-ATPase subunit interface; other site 93061007110 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 93061007111 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 93061007112 Walker A/P-loop; other site 93061007113 ATP binding site [chemical binding]; other site 93061007114 Q-loop/lid; other site 93061007115 ABC transporter signature motif; other site 93061007116 Walker B; other site 93061007117 D-loop; other site 93061007118 H-loop/switch region; other site 93061007119 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 93061007120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 93061007121 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 93061007122 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 93061007123 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 93061007124 amino acid transporter; Region: 2A0306; TIGR00909 93061007125 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 93061007126 substrate binding pocket [chemical binding]; other site 93061007127 catalytic triad [active] 93061007128 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 93061007129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061007130 putative substrate translocation pore; other site 93061007131 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 93061007132 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 93061007133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061007134 Walker A/P-loop; other site 93061007135 ATP binding site [chemical binding]; other site 93061007136 Q-loop/lid; other site 93061007137 ABC transporter signature motif; other site 93061007138 Walker B; other site 93061007139 D-loop; other site 93061007140 H-loop/switch region; other site 93061007141 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 93061007142 oligomer interface [polypeptide binding]; other site 93061007143 active site 93061007144 metal binding site [ion binding]; metal-binding site 93061007145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 93061007146 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 93061007147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 93061007148 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 93061007149 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 93061007150 active site 93061007151 FMN binding site [chemical binding]; other site 93061007152 substrate binding site [chemical binding]; other site 93061007153 3Fe-4S cluster binding site [ion binding]; other site 93061007154 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 93061007155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061007156 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061007157 putative substrate translocation pore; other site 93061007158 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 93061007159 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 93061007160 Walker A/P-loop; other site 93061007161 ATP binding site [chemical binding]; other site 93061007162 Q-loop/lid; other site 93061007163 ABC transporter signature motif; other site 93061007164 Walker B; other site 93061007165 D-loop; other site 93061007166 H-loop/switch region; other site 93061007167 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 93061007168 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 93061007169 Walker A/P-loop; other site 93061007170 ATP binding site [chemical binding]; other site 93061007171 Q-loop/lid; other site 93061007172 ABC transporter signature motif; other site 93061007173 Walker B; other site 93061007174 D-loop; other site 93061007175 H-loop/switch region; other site 93061007176 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 93061007177 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 93061007178 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 93061007179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061007180 dimer interface [polypeptide binding]; other site 93061007181 conserved gate region; other site 93061007182 putative PBP binding loops; other site 93061007183 ABC-ATPase subunit interface; other site 93061007184 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 93061007185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93061007186 dimer interface [polypeptide binding]; other site 93061007187 conserved gate region; other site 93061007188 putative PBP binding loops; other site 93061007189 ABC-ATPase subunit interface; other site 93061007190 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 93061007191 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 93061007192 substrate binding site [chemical binding]; other site 93061007193 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 93061007194 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 93061007195 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 93061007196 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 93061007197 classical (c) SDRs; Region: SDR_c; cd05233 93061007198 NAD(P) binding site [chemical binding]; other site 93061007199 active site 93061007200 AbgT putative transporter family; Region: ABG_transport; pfam03806 93061007201 Uncharacterized conserved protein [Function unknown]; Region: COG2128 93061007202 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 93061007203 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 93061007204 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 93061007205 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 93061007206 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 93061007207 classical (c) SDRs; Region: SDR_c; cd05233 93061007208 NAD(P) binding site [chemical binding]; other site 93061007209 active site 93061007210 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 93061007211 Protein of unknown function, DUF576; Region: DUF576; pfam04507 93061007212 Protein of unknown function, DUF576; Region: DUF576; pfam04507 93061007213 Protein of unknown function, DUF576; Region: DUF576; pfam04507 93061007214 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 93061007215 PLD-like domain; Region: PLDc_2; pfam13091 93061007216 putative homodimer interface [polypeptide binding]; other site 93061007217 putative active site [active] 93061007218 catalytic site [active] 93061007219 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 93061007220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93061007221 ATP binding site [chemical binding]; other site 93061007222 putative Mg++ binding site [ion binding]; other site 93061007223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93061007224 nucleotide binding region [chemical binding]; other site 93061007225 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 93061007226 ATP-binding site [chemical binding]; other site 93061007227 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 93061007228 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 93061007229 active site 93061007230 8-oxo-dGMP binding site [chemical binding]; other site 93061007231 nudix motif; other site 93061007232 metal binding site [ion binding]; metal-binding site 93061007233 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 93061007234 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 93061007235 active site 93061007236 substrate binding site [chemical binding]; other site 93061007237 metal binding site [ion binding]; metal-binding site 93061007238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061007239 H+ Antiporter protein; Region: 2A0121; TIGR00900 93061007240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061007241 putative substrate translocation pore; other site 93061007242 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 93061007243 legume lectins; Region: lectin_L-type; cl14058 93061007244 homotetramer interaction site [polypeptide binding]; other site 93061007245 carbohydrate binding site [chemical binding]; other site 93061007246 metal binding site [ion binding]; metal-binding site 93061007247 G5 domain; Region: G5; pfam07501 93061007248 G5 domain; Region: G5; pfam07501 93061007249 G5 domain; Region: G5; pfam07501 93061007250 G5 domain; Region: G5; pfam07501 93061007251 G5 domain; Region: G5; pfam07501 93061007252 G5 domain; Region: G5; pfam07501 93061007253 G5 domain; Region: G5; pfam07501 93061007254 G5 domain; Region: G5; pfam07501 93061007255 G5 domain; Region: G5; pfam07501 93061007256 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 93061007257 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 93061007258 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061007259 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 93061007260 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061007261 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 93061007262 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 93061007263 tetramer interface; other site 93061007264 active site 93061007265 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 93061007266 Fibronectin binding repeat; Region: Fn_bind; pfam02986 93061007267 Fibronectin binding repeat; Region: Fn_bind; pfam02986 93061007268 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 93061007269 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 93061007270 Fibronectin binding repeat; Region: Fn_bind; pfam02986 93061007271 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 93061007272 GntP family permease; Region: GntP_permease; pfam02447 93061007273 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 93061007274 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 93061007275 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 93061007276 N- and C-terminal domain interface [polypeptide binding]; other site 93061007277 active site 93061007278 catalytic site [active] 93061007279 metal binding site [ion binding]; metal-binding site 93061007280 carbohydrate binding site [chemical binding]; other site 93061007281 ATP binding site [chemical binding]; other site 93061007282 Transcriptional regulators [Transcription]; Region: GntR; COG1802 93061007283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 93061007284 DNA-binding site [nucleotide binding]; DNA binding site 93061007285 FCD domain; Region: FCD; pfam07729 93061007286 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 93061007287 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 93061007288 DNA binding residues [nucleotide binding] 93061007289 dimer interface [polypeptide binding]; other site 93061007290 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 93061007291 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 93061007292 synthetase active site [active] 93061007293 NTP binding site [chemical binding]; other site 93061007294 metal binding site [ion binding]; metal-binding site 93061007295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 93061007296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061007297 D-galactonate transporter; Region: 2A0114; TIGR00893 93061007298 putative substrate translocation pore; other site 93061007299 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 93061007300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93061007301 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93061007302 putative substrate translocation pore; other site 93061007303 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061007304 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 93061007305 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 93061007306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061007307 Walker A/P-loop; other site 93061007308 ATP binding site [chemical binding]; other site 93061007309 Q-loop/lid; other site 93061007310 ABC transporter signature motif; other site 93061007311 Walker B; other site 93061007312 D-loop; other site 93061007313 H-loop/switch region; other site 93061007314 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 93061007315 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 93061007316 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 93061007317 Predicted esterase [General function prediction only]; Region: COG0400 93061007318 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 93061007319 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 93061007320 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 93061007321 Zn binding site [ion binding]; other site 93061007322 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061007323 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 93061007324 putative Zn2+ binding site [ion binding]; other site 93061007325 putative DNA binding site [nucleotide binding]; other site 93061007326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061007327 Coenzyme A binding pocket [chemical binding]; other site 93061007328 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 93061007329 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 93061007330 putative metal binding site [ion binding]; other site 93061007331 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 93061007332 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 93061007333 dimer interface [polypeptide binding]; other site 93061007334 FMN binding site [chemical binding]; other site 93061007335 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 93061007336 D-lactate dehydrogenase; Validated; Region: PRK08605 93061007337 ligand binding site [chemical binding]; other site 93061007338 NAD binding site [chemical binding]; other site 93061007339 homodimer interface [polypeptide binding]; other site 93061007340 catalytic site [active] 93061007341 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 93061007342 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93061007343 active site 93061007344 motif I; other site 93061007345 motif II; other site 93061007346 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 93061007347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93061007348 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 93061007349 Walker A/P-loop; other site 93061007350 ATP binding site [chemical binding]; other site 93061007351 Q-loop/lid; other site 93061007352 ABC transporter signature motif; other site 93061007353 Walker B; other site 93061007354 D-loop; other site 93061007355 H-loop/switch region; other site 93061007356 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 93061007357 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 93061007358 active site 93061007359 catalytic site [active] 93061007360 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 93061007361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061007362 Coenzyme A binding pocket [chemical binding]; other site 93061007363 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 93061007364 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 93061007365 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 93061007366 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 93061007367 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 93061007368 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 93061007369 EamA-like transporter family; Region: EamA; pfam00892 93061007370 EamA-like transporter family; Region: EamA; pfam00892 93061007371 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 93061007372 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 93061007373 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 93061007374 catalytic residues [active] 93061007375 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 93061007376 active site 93061007377 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 93061007378 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 93061007379 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 93061007380 active site turn [active] 93061007381 phosphorylation site [posttranslational modification] 93061007382 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 93061007383 HPr interaction site; other site 93061007384 glycerol kinase (GK) interaction site [polypeptide binding]; other site 93061007385 active site 93061007386 phosphorylation site [posttranslational modification] 93061007387 pyruvate oxidase; Provisional; Region: PRK08611 93061007388 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 93061007389 PYR/PP interface [polypeptide binding]; other site 93061007390 tetramer interface [polypeptide binding]; other site 93061007391 dimer interface [polypeptide binding]; other site 93061007392 TPP binding site [chemical binding]; other site 93061007393 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 93061007394 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 93061007395 TPP-binding site [chemical binding]; other site 93061007396 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 93061007397 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 93061007398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 93061007399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 93061007400 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 93061007401 putative dimerization interface [polypeptide binding]; other site 93061007402 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 93061007403 Surface antigen [General function prediction only]; Region: COG3942 93061007404 CHAP domain; Region: CHAP; pfam05257 93061007405 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 93061007406 homodimer interface [polypeptide binding]; other site 93061007407 catalytic residues [active] 93061007408 NAD binding site [chemical binding]; other site 93061007409 substrate binding pocket [chemical binding]; other site 93061007410 flexible flap; other site 93061007411 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 93061007412 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 93061007413 dimer interface [polypeptide binding]; other site 93061007414 active site 93061007415 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 93061007416 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 93061007417 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 93061007418 DNA binding site [nucleotide binding] 93061007419 active site 93061007420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061007421 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 93061007422 Walker A motif; other site 93061007423 ATP binding site [chemical binding]; other site 93061007424 Walker B motif; other site 93061007425 arginine finger; other site 93061007426 UvrB/uvrC motif; Region: UVR; pfam02151 93061007427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93061007428 Walker A motif; other site 93061007429 ATP binding site [chemical binding]; other site 93061007430 Walker B motif; other site 93061007431 arginine finger; other site 93061007432 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 93061007433 Virus attachment protein p12 family; Region: P12; pfam12669 93061007434 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 93061007435 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 93061007436 G1 box; other site 93061007437 GTP/Mg2+ binding site [chemical binding]; other site 93061007438 Switch I region; other site 93061007439 G2 box; other site 93061007440 G3 box; other site 93061007441 Switch II region; other site 93061007442 G4 box; other site 93061007443 G5 box; other site 93061007444 Nucleoside recognition; Region: Gate; pfam07670 93061007445 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 93061007446 Nucleoside recognition; Region: Gate; pfam07670 93061007447 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 93061007448 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 93061007449 MMPL family; Region: MMPL; pfam03176 93061007450 MMPL family; Region: MMPL; cl14618 93061007451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 93061007452 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 93061007453 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 93061007454 Glutamate binding site [chemical binding]; other site 93061007455 homodimer interface [polypeptide binding]; other site 93061007456 NAD binding site [chemical binding]; other site 93061007457 catalytic residues [active] 93061007458 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 93061007459 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 93061007460 active site 93061007461 substrate binding site [chemical binding]; other site 93061007462 trimer interface [polypeptide binding]; other site 93061007463 CoA binding site [chemical binding]; other site 93061007464 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 93061007465 metal-binding site [ion binding] 93061007466 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 93061007467 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 93061007468 metal-binding site [ion binding] 93061007469 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 93061007470 Soluble P-type ATPase [General function prediction only]; Region: COG4087 93061007471 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 93061007472 metal-binding site [ion binding] 93061007473 D-lactate dehydrogenase; Validated; Region: PRK08605 93061007474 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 93061007475 homodimer interface [polypeptide binding]; other site 93061007476 ligand binding site [chemical binding]; other site 93061007477 NAD binding site [chemical binding]; other site 93061007478 catalytic site [active] 93061007479 LL-diaminopimelate aminotransferase; Region: DapC_direct; TIGR03540 93061007480 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93061007481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061007482 homodimer interface [polypeptide binding]; other site 93061007483 catalytic residue [active] 93061007484 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 93061007485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93061007486 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 93061007487 active site lid residues [active] 93061007488 substrate binding pocket [chemical binding]; other site 93061007489 catalytic residues [active] 93061007490 substrate-Mg2+ binding site; other site 93061007491 aspartate-rich region 1; other site 93061007492 aspartate-rich region 2; other site 93061007493 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 93061007494 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 93061007495 active site 93061007496 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93061007497 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 93061007498 Argininosuccinate lyase C-terminal; Region: ASL_C2; cl17237 93061007499 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 93061007500 Surface antigen [General function prediction only]; Region: COG3942 93061007501 CHAP domain; Region: CHAP; pfam05257 93061007502 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 93061007503 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 93061007504 catalytic triad [active] 93061007505 catalytic triad [active] 93061007506 oxyanion hole [active] 93061007507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061007508 Coenzyme A binding pocket [chemical binding]; other site 93061007509 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 93061007510 catalytic residue [active] 93061007511 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 93061007512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 93061007513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 93061007514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 93061007515 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 93061007516 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 93061007517 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 93061007518 NADP binding site [chemical binding]; other site 93061007519 active site 93061007520 regulatory binding site [polypeptide binding]; other site 93061007521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 93061007522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 93061007523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 93061007524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93061007525 short chain dehydrogenase; Region: adh_short; pfam00106 93061007526 NAD(P) binding site [chemical binding]; other site 93061007527 active site 93061007528 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 93061007529 Putative lysophospholipase; Region: Hydrolase_4; cl19140 93061007530 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 93061007531 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 93061007532 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 93061007533 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 93061007534 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 93061007535 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 93061007536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 93061007537 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 93061007538 Phosphotransferase enzyme family; Region: APH; pfam01636 93061007539 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 93061007540 active site 93061007541 substrate binding site [chemical binding]; other site 93061007542 ATP binding site [chemical binding]; other site 93061007543 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 93061007544 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 93061007545 quinone interaction residues [chemical binding]; other site 93061007546 active site 93061007547 catalytic residues [active] 93061007548 FMN binding site [chemical binding]; other site 93061007549 substrate binding site [chemical binding]; other site 93061007550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 93061007551 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 93061007552 dimer interface [polypeptide binding]; other site 93061007553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 93061007554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 93061007555 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 93061007556 Predicted acyl esterases [General function prediction only]; Region: COG2936 93061007557 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 93061007558 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 93061007559 tetramerization interface [polypeptide binding]; other site 93061007560 active site 93061007561 Pantoate-beta-alanine ligase; Region: PanC; cd00560 93061007562 active site 93061007563 ATP-binding site [chemical binding]; other site 93061007564 pantoate-binding site; other site 93061007565 HXXH motif; other site 93061007566 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 93061007567 active site 93061007568 oligomerization interface [polypeptide binding]; other site 93061007569 metal binding site [ion binding]; metal-binding site 93061007570 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 93061007571 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 93061007572 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 93061007573 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 93061007574 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 93061007575 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 93061007576 tetramer (dimer of dimers) interface [polypeptide binding]; other site 93061007577 NAD binding site [chemical binding]; other site 93061007578 dimer interface [polypeptide binding]; other site 93061007579 substrate binding site [chemical binding]; other site 93061007580 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 93061007581 amino acid transporter; Region: 2A0306; TIGR00909 93061007582 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 93061007583 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 93061007584 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 93061007585 inhibitor-cofactor binding pocket; inhibition site 93061007586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061007587 catalytic residue [active] 93061007588 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 93061007589 catalytic residue [active] 93061007590 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 93061007591 Predicted dehydrogenase [General function prediction only]; Region: COG0579 93061007592 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 93061007593 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 93061007594 acyl-activating enzyme (AAE) consensus motif; other site 93061007595 AMP binding site [chemical binding]; other site 93061007596 active site 93061007597 CoA binding site [chemical binding]; other site 93061007598 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 93061007599 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 93061007600 choline dehydrogenase; Validated; Region: PRK02106 93061007601 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 93061007602 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 93061007603 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 93061007604 tetramerization interface [polypeptide binding]; other site 93061007605 NAD(P) binding site [chemical binding]; other site 93061007606 catalytic residues [active] 93061007607 Predicted transcriptional regulators [Transcription]; Region: COG1510 93061007608 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 93061007609 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 93061007610 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 93061007611 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93061007612 FeS/SAM binding site; other site 93061007613 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 93061007614 Class III ribonucleotide reductase; Region: RNR_III; cd01675 93061007615 effector binding site; other site 93061007616 active site 93061007617 Zn binding site [ion binding]; other site 93061007618 glycine loop; other site 93061007619 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 93061007620 Citrate transporter; Region: CitMHS; pfam03600 93061007621 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 93061007622 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 93061007623 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 93061007624 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 93061007625 Flavodoxin; Region: Flavodoxin_1; pfam00258 93061007626 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 93061007627 FAD binding pocket [chemical binding]; other site 93061007628 FAD binding motif [chemical binding]; other site 93061007629 catalytic residues [active] 93061007630 NAD binding pocket [chemical binding]; other site 93061007631 phosphate binding motif [ion binding]; other site 93061007632 beta-alpha-beta structure motif; other site 93061007633 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 93061007634 catalytic residues [active] 93061007635 dimer interface [polypeptide binding]; other site 93061007636 FtsX-like permease family; Region: FtsX; pfam02687 93061007637 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 93061007638 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 93061007639 Walker A/P-loop; other site 93061007640 ATP binding site [chemical binding]; other site 93061007641 Q-loop/lid; other site 93061007642 ABC transporter signature motif; other site 93061007643 Walker B; other site 93061007644 D-loop; other site 93061007645 H-loop/switch region; other site 93061007646 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 93061007647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93061007648 ATP binding site [chemical binding]; other site 93061007649 Mg2+ binding site [ion binding]; other site 93061007650 G-X-G motif; other site 93061007651 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 93061007652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93061007653 active site 93061007654 phosphorylation site [posttranslational modification] 93061007655 intermolecular recognition site; other site 93061007656 dimerization interface [polypeptide binding]; other site 93061007657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93061007658 DNA binding site [nucleotide binding] 93061007659 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 93061007660 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 93061007661 dimer interface [polypeptide binding]; other site 93061007662 active site 93061007663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 93061007664 Transcriptional regulators [Transcription]; Region: MarR; COG1846 93061007665 putative Zn2+ binding site [ion binding]; other site 93061007666 putative DNA binding site [nucleotide binding]; other site 93061007667 dimerization interface [polypeptide binding]; other site 93061007668 Predicted esterase [General function prediction only]; Region: COG0627 93061007669 S-formylglutathione hydrolase; Region: PLN02442 93061007670 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 93061007671 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 93061007672 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 93061007673 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 93061007674 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 93061007675 ligand binding site [chemical binding]; other site 93061007676 flexible hinge region; other site 93061007677 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 93061007678 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 93061007679 putative substrate binding site [chemical binding]; other site 93061007680 nucleotide binding site [chemical binding]; other site 93061007681 nucleotide binding site [chemical binding]; other site 93061007682 homodimer interface [polypeptide binding]; other site 93061007683 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 93061007684 ornithine carbamoyltransferase; Validated; Region: PRK02102 93061007685 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 93061007686 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 93061007687 arginine deiminase; Provisional; Region: PRK01388 93061007688 Arginine repressor [Transcription]; Region: ArgR; COG1438 93061007689 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 93061007690 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 93061007691 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 93061007692 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 93061007693 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 93061007694 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 93061007695 active site 93061007696 Zn binding site [ion binding]; other site 93061007697 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 93061007698 HTH domain; Region: HTH_11; pfam08279 93061007699 PRD domain; Region: PRD; pfam00874 93061007700 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 93061007701 active site 93061007702 P-loop; other site 93061007703 phosphorylation site [posttranslational modification] 93061007704 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 93061007705 active site 93061007706 phosphorylation site [posttranslational modification] 93061007707 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 93061007708 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 93061007709 active site 93061007710 P-loop; other site 93061007711 phosphorylation site [posttranslational modification] 93061007712 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 93061007713 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 93061007714 active site 93061007715 phosphorylation site [posttranslational modification] 93061007716 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 93061007717 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 93061007718 Predicted membrane protein [Function unknown]; Region: COG1511 93061007719 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 93061007720 Retro-transposon transporting motif; Region: Nup_retrotrp_bd; pfam10599 93061007721 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 93061007722 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 93061007723 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 93061007724 CHAP domain; Region: CHAP; pfam05257 93061007725 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 93061007726 catalytic triad [active] 93061007727 conserved cis-peptide bond; other site 93061007728 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 93061007729 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 93061007730 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 93061007731 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 93061007732 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 93061007733 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 93061007734 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 93061007735 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93061007736 ATP binding site [chemical binding]; other site 93061007737 putative Mg++ binding site [ion binding]; other site 93061007738 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 93061007739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93061007740 nucleotide binding region [chemical binding]; other site 93061007741 ATP-binding site [chemical binding]; other site 93061007742 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 93061007743 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 93061007744 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 93061007745 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 93061007746 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 93061007747 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 93061007748 SecY translocase; Region: SecY; pfam00344 93061007749 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 93061007750 legume lectins; Region: lectin_L-type; cd01951 93061007751 homotetramer interaction site [polypeptide binding]; other site 93061007752 carbohydrate binding site [chemical binding]; other site 93061007753 metal binding site [ion binding]; metal-binding site 93061007754 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 93061007755 Putative Ig domain; Region: He_PIG; pfam05345 93061007756 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 93061007757 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 93061007758 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 93061007759 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 93061007760 methionine sulfoxide reductase A; Provisional; Region: PRK05528 93061007761 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 93061007762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93061007763 Coenzyme A binding pocket [chemical binding]; other site 93061007764 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 93061007765 PHP domain; Region: PHP; pfam02811 93061007766 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 93061007767 AAA domain; Region: AAA_31; pfam13614 93061007768 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 93061007769 Chain length determinant protein; Region: Wzz; pfam02706 93061007770 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 93061007771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 93061007772 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 93061007773 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 93061007774 DXD motif; other site 93061007775 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 93061007776 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 93061007777 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 93061007778 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 93061007779 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 93061007780 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 93061007781 substrate binding site [chemical binding]; other site 93061007782 glutamase interaction surface [polypeptide binding]; other site 93061007783 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 93061007784 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 93061007785 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 93061007786 metal binding site [ion binding]; metal-binding site 93061007787 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 93061007788 catalytic residues [active] 93061007789 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 93061007790 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 93061007791 putative active site [active] 93061007792 oxyanion strand; other site 93061007793 catalytic triad [active] 93061007794 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 93061007795 putative active site pocket [active] 93061007796 4-fold oligomerization interface [polypeptide binding]; other site 93061007797 metal binding residues [ion binding]; metal-binding site 93061007798 3-fold/trimer interface [polypeptide binding]; other site 93061007799 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 93061007800 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93061007801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93061007802 homodimer interface [polypeptide binding]; other site 93061007803 catalytic residue [active] 93061007804 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 93061007805 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 93061007806 NAD binding site [chemical binding]; other site 93061007807 dimerization interface [polypeptide binding]; other site 93061007808 product binding site; other site 93061007809 substrate binding site [chemical binding]; other site 93061007810 zinc binding site [ion binding]; other site 93061007811 catalytic residues [active] 93061007812 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 93061007813 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 93061007814 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 93061007815 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 93061007816 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 93061007817 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 93061007818 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 93061007819 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 93061007820 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 93061007821 Walker A/P-loop; other site 93061007822 ATP binding site [chemical binding]; other site 93061007823 Q-loop/lid; other site 93061007824 ABC transporter signature motif; other site 93061007825 Walker B; other site 93061007826 D-loop; other site 93061007827 H-loop/switch region; other site 93061007828 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 93061007829 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 93061007830 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 93061007831 Walker A/P-loop; other site 93061007832 ATP binding site [chemical binding]; other site 93061007833 Q-loop/lid; other site 93061007834 ABC transporter signature motif; other site 93061007835 Walker B; other site 93061007836 D-loop; other site 93061007837 H-loop/switch region; other site 93061007838 hypothetical protein; Provisional; Region: PRK13661 93061007839 Uncharacterized conserved protein [Function unknown]; Region: COG1912 93061007840 Uncharacterized conserved protein [Function unknown]; Region: COG2353 93061007841 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 93061007842 Strictosidine synthase; Region: Str_synth; cl19733 93061007843 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 93061007844 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 93061007845 active site residue [active] 93061007846 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 93061007847 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 93061007848 putative substrate binding pocket [chemical binding]; other site 93061007849 AC domain interface; other site 93061007850 catalytic triad [active] 93061007851 AB domain interface; other site 93061007852 interchain disulfide; other site 93061007853 hypothetical protein; Validated; Region: PRK07668 93061007854 Predicted transcriptional regulators [Transcription]; Region: COG1695 93061007855 DinB superfamily; Region: DinB_2; pfam12867 93061007856 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 93061007857 anion transporter; Region: dass; TIGR00785 93061007858 transmembrane helices; other site 93061007859 Predicted permeases [General function prediction only]; Region: RarD; COG2962 93061007860 EamA-like transporter family; Region: EamA; pfam00892 93061007861 hypothetical protein; Provisional; Region: PRK07758 93061007862 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 93061007863 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 93061007864 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 93061007865 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 93061007866 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 93061007867 Walker A/P-loop; other site 93061007868 ATP binding site [chemical binding]; other site 93061007869 Q-loop/lid; other site 93061007870 ABC transporter signature motif; other site 93061007871 Walker B; other site 93061007872 D-loop; other site 93061007873 H-loop/switch region; other site 93061007874 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 93061007875 FtsX-like permease family; Region: FtsX; pfam02687 93061007876 Integrase core domain; Region: rve; pfam00665 93061007877 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 93061007878 Integrase core domain; Region: rve_3; pfam13683 93061007879 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 93061007880 Integrase core domain; Region: rve_3; cl15866 93061007881 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 93061007882 DNA-binding site [nucleotide binding]; DNA binding site 93061007883 RNA-binding motif; other site 93061007884 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 93061007885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93061007886 non-specific DNA binding site [nucleotide binding]; other site 93061007887 salt bridge; other site 93061007888 sequence-specific DNA binding site [nucleotide binding]; other site 93061007889 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 93061007890 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 93061007891 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 93061007892 ParB-like nuclease domain; Region: ParBc; pfam02195 93061007893 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 93061007894 Methyltransferase domain; Region: Methyltransf_31; pfam13847 93061007895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93061007896 S-adenosylmethionine binding site [chemical binding]; other site 93061007897 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 93061007898 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 93061007899 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 93061007900 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 93061007901 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 93061007902 trmE is a tRNA modification GTPase; Region: trmE; cd04164 93061007903 G1 box; other site 93061007904 GTP/Mg2+ binding site [chemical binding]; other site 93061007905 Switch I region; other site 93061007906 G2 box; other site 93061007907 Switch II region; other site 93061007908 G3 box; other site 93061007909 G4 box; other site 93061007910 G5 box; other site 93061007911 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 93061007912 ribonuclease P; Reviewed; Region: rnpA; PRK00499 93061007913 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399