-- dump date 20140620_074643 -- class Genbank::CDS -- table cds_note -- id note YP_001331036.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001331037.1 binds the polymerase to DNA and acts as a sliding clamp YP_001331038.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001331041.1 similar to functionally unknown protein YP_001331042.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_001331043.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001331044.1 similar to branched-chain amino acid transport protein YP_001331045.1 similar to functionally unknown protein YP_001331046.1 similar to homoserine-o-acetyltransferase YP_001331047.1 similar to functionally unknown protein YP_001331048.1 similar to functionally unknown protein YP_001331049.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001331051.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001331054.1 similar to functionally unknown protein YP_001331055.1 similar to functionally unknown protein YP_001331057.1 similar to 5'-nucleotidase family protein YP_001331058.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001331059.1 similar to functionally unknown protein YP_001331060.1 similar to functionally unknown protein YP_001331061.1 similar to functionally unknown protein YP_001331062.1 similar to functionally unknown protein YP_001331064.1 similar to oxidoreductase YP_001331065.1 similar to dihydrouridine synthase YP_001331066.1 similar to functionally unknown protein YP_001331067.1 similar to permiase YP_001331068.1 no similarity YP_001331069.1 similar to functionally unknown protein YP_001331071.1 similar to functionally unknown protein YP_001331072.1 similar to LysR family regulatory protein YP_001331073.1 similar to functionally unknown protein YP_001331074.1 similar to functionally unknown protein YP_001331075.1 similar to functionally unknown protein YP_001331076.1 similar to 1-phosphatidylinositol phosphodiesterase precursor YP_001331077.1 similar to functionally unknown protein YP_001331078.1 similar to functionally unknown protein YP_001331079.1 similar to functionally unknown protein YP_001331080.1 similar to functionally unknown protein YP_001331081.1 similar to HTH-type transcriptional regulator YP_001331082.1 similar to peptidase family protein YP_001331083.1 similar to transporter protein YP_001331084.1 similar to Na+ Pi-cotransporter YP_001331085.1 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever YP_001331086.1 similar to membrane transporter protein YP_001331087.1 aminotransferase class I YP_001331088.1 similar to functionally unknown protein YP_001331103.1 similar to functionally unknown protein YP_001331104.1 similar to functionally unknown protein YP_001331105.1 similar to functionally unknown protein YP_001331108.1 similar to sugar transferase YP_001331110.1 similar to capsular polysaccharide synthesis protein YP_001331113.1 similar to functionally unknown protein YP_001331114.1 similar to transcriptional regulator, GntR family protein YP_001331115.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_001331116.1 similar to membrane transporter protein YP_001331117.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_001331118.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_001331122.1 similar to transporter protein YP_001331123.1 similar to nucleotidase family protein YP_001331124.1 similar to DNA-binding protein YP_001331125.1 similar to replication initiation protein YP_001331126.1 similar to replication initiation protein YP_001331127.1 similar to functionally unknown protein YP_001331133.1 dTDP-4-dehydrorhamnose reductase YP_001331136.1 UDP-N-acetylglucosamine 2-epimerase YP_001331143.1 UDP-glucose 4-epimerase YP_001331144.1 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase YP_001331146.1 iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source YP_001331147.1 similar to functionally unknown protein YP_001331150.1 similar to functionally unknown protein YP_001331151.1 similar to ABC transporter ATP-binding protein YP_001331152.1 similar to ABC transporter protein YP_001331153.1 similar to ABC transporter permease YP_001331154.1 similar to functionally unknown protein YP_001331155.1 similar to functionally unknown protein YP_001331156.1 Catalyzes the reversible two-electron oxidation of formate to carbon dioxide. It allows the assimilation of carbon dioxide and provides energy for growth through oxidative phosphorylation coupled to the reduction of oxygen, nitrate, sulphate or fumarate YP_001331157.1 similar to transporter protein YP_001331158.1 similar to surfactin synthetase YP_001331160.1 similar to functionally unknown protein YP_001331161.1 NAG kinase, N-acetyl-L-glutamate 5-phosphotransferase YP_001331162.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_001331163.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001331169.1 similar to functionally unknown protein YP_001331170.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_001331173.1 similar to functionally unknown protein YP_001331175.1 similar to functionally unknown protein YP_001331176.1 similar to functionally unknown protein YP_001331177.1 similar to functionally unknown protein YP_001331182.1 similar to gamma-glutamyltranspeptidase YP_001331183.1 similar to functionally unknown protein YP_001331184.2 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_001331185.1 similar to peptidase YP_001331186.1 similar to ABC transporter ATP-binding protein YP_001331187.1 smilar to extracellular sugar-binding lipoprotein YP_001331188.1 similar to sugar transport system permease YP_001331189.1 similar to sugar transport system permease YP_001331190.1 similar to oxidoreductase YP_001331191.1 similar to functionally unknown protein YP_001331192.1 similar to functionally unknown protein YP_001331193.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate YP_001331195.1 similar to two-component sensor histidine kinase YP_001331196.1 similar to periplasmic-iron-binding protein YP_001331198.1 similar to formate-lyase activating enzyme YP_001331200.1 similar to functionally unknown protein YP_001331207.1 similar to functionally unknown protein YP_001331209.1 similar to functionally unknown protein YP_001331212.1 similar to PTS transport system, IIBC component YP_001331213.1 similar to inosine-uridine preferring nucleoside hydrolase YP_001331215.1 similar to PTS transport system, IIA component YP_001331216.1 similar to PTS transport system, IIB component YP_001331217.1 similar to PTS transport system, IIC component YP_001331219.1 similar to zinc-binding dehydrogenase YP_001331220.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_001331222.1 similar to teichoic acid biosynthesis protein B YP_001331223.1 similar to teichoic acid biosynthesis protein F YP_001331224.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_001331225.1 similar to xylitol dehydrogenase YP_001331226.1 similar to teichoic acid biosynthesis protein YP_001331228.1 involved in peptidoglycan cross-linking YP_001331231.1 negatively regulates murein hydrolase activity YP_001331232.1 in conjunction with LrgA this protein inhibits the expression or activity of extracellular murein hydrolases YP_001331235.1 similar to functionally unknown protein YP_001331237.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_001331240.1 similar to functionally unknown protein YP_001331241.1 similar to IS1272 transposase YP_001331242.1 similar to transmembrane efflux pump protein YP_001331245.1 similar to ABC transporter ATP-binding protein YP_001331246.1 similar to functionally unknown protein YP_001331247.1 similar to functionally unknown protein YP_001331248.1 no similarity YP_001331249.1 similar to functionally unknown protein YP_001331250.1 similar to functionally unknown protein YP_001331251.1 similar to functionally unknown protein YP_001331253.1 similar to functionally unknown protein YP_001331254.1 similar to functionally unknown protein YP_001331255.1 similar to functionally unknown protein YP_001331256.1 similar to functionally unknown protein YP_001331257.1 similar to functionally unknown protein YP_001331258.1 similar to functionally unknown protein YP_001331259.1 similar to functionally unknown protein YP_001331260.1 similar to functionally unknown protein YP_001331261.1 similar to functionally unknown protein YP_001331262.1 similar to functionally unknown protein YP_001331263.1 similar to functionally unknown protein YP_001331264.1 similar to functionally unknown protein YP_001331265.1 similar to functionally unknown protein YP_001331266.1 similar to functionally unknown protein YP_001331267.1 similar to functionally unknown protein YP_001331268.1 similar to functionally unknown protein YP_001331269.1 similar to functionally unknown protein YP_001331270.1 similar to functionally unknown protein YP_001331271.1 similar to unknown lipoprotein YP_001331272.1 similar to functionally unknown protein YP_001331273.1 similar to functionally unknown protein YP_001331274.1 similar to functionally unknown protein YP_001331275.1 similar to functionally unknown protein YP_001331276.1 similar to functionally unknown protein YP_001331277.1 similar to functionally unknown protein YP_001331278.2 similar to functionally unknown protein YP_001331279.1 similar to functionally unknown protein YP_001331280.1 similar to functionally unknown protein YP_001331286.1 similar to regulatory protein PfoR family YP_001331287.1 similar to carbohydrate kinase pfkB family protein YP_001331288.1 similar to functionally unknown protein YP_001331289.1 similar to nucleoside permease YP_001331290.1 similar to functionally unknown protein YP_001331291.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid YP_001331292.1 similar to sugar kinase YP_001331293.1 similar to transcriptional regulator YP_001331294.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_001331295.1 similar to functionally unknown protein YP_001331297.1 integrase for bacteriophage phiNM4 YP_001331298.1 similar to ORF013 of Bacteriophage 53 [Bacteriophage phiNM4] YP_001331299.1 similar to ORF030 of Bacteriophage 71 [Bacteriophage phiNM4] YP_001331300.1 similar to ORF022 of Bacteriophage 71 [Bacteriophage phiNM4] YP_001331301.1 similar to ORF029 of Bacteriophage 71 [Bacteriophage phiNM4] YP_001331302.1 anti-repressor protein for bacteriophage phiNM4 YP_001331303.1 similar to ORF048 of Bacteriophage 77 [Bacteriophage phiNM4] YP_001331304.1 similar to ORF043 of Bacteriophage 77 [Bacteriophage phiNM4] YP_001331305.1 similar to ORF012 of Bacteriophage 77 [Bacteriophage phiNM4] YP_001331306.1 similar to ORF012 of Bacteriophage 77 [Bacteriophage phiNM4] YP_001331307.1 similar to ORF018 of Bacteriophage 77 [Bacteriophage phiNM4] YP_001331308.1 similar to ORF013 of Bacteriophage 92 [Bacteriophage phiNM4] YP_001331309.1 similar to ORF019 of Bacteriophage 53 [Bacteriophage phiNM4] YP_001331310.1 identical to ORF018 of Bacteriophage 53 [Bacteriophage phiNM4] YP_001331311.1 identical to ORF030 of Bacteriophage ROSA [Bacteriophage phiNM4] YP_001331312.1 identical to ORF038 of Bacteriophage ROSA [Bacteriophage phiNM4] YP_001331313.1 identical to ORF062 of Bacteriophage ROSA [Bacteriophage phiNM4] YP_001331314.1 similar to ORF061 of Bacteriophage ROSA [Bacteriophage phiNM4] YP_001331315.1 similar to ORF032 of Bacteriophage 53 [Bacteriophage phiNM4] YP_001331316.1 similar to phage protein 1671 of Enterococcus faecium DO [Bacteriophage phiNM4] YP_001331317.1 similar to ORF31 of bacteriophage phi ETA [Bacteriophage phiNM4] YP_001331318.1 similar to phi ETA orf 34-like protein [Bacteriophage phiNM4] YP_001331319.1 identical to ORF068 of Bacteriophage 92 [Bacteriophage phiNM4] YP_001331320.1 similar to ORF31 of phiPV83 [Bacteriophage phiNM4] YP_001331321.1 identical to ORF038 of Bacteriophage X2 [Bacteriophage phiNM4] YP_001331322.1 similar to ORF027 of Bacteriophage 96 [Bacteriophage phiNM4] YP_001331323.1 terminase large subunit for bacteriophage phiNM4 YP_001331324.1 portal protein for bacteriophage phiNM4 YP_001331325.1 similar to ORF012 of Bacteriophage 96 [Bacteriophage phiNM4] YP_001331326.1 similar to ORF046 of Bacteriophage 96 [Bacteriophage phiNM4] YP_001331327.1 similar to ORF019 of Bacteriophage 96 [Bacteriophage phiNM4] YP_001331328.1 major head protein for bacteriophage phiNM4 YP_001331329.1 similar to ORF041 of Bacteriophage 96 [Bacteriophage phiNM4] YP_001331330.1 similar to ORF044 of Bacteriophage 96 [Bacteriophage phiNM4] YP_001331331.1 similar to ORF029 of Bacteriophage 96 [Bacteriophage phiNM4] YP_001331332.1 identical to ORF027 of Bacteriophage ROSA [Bacteriophage phiNM4] YP_001331333.1 identical to ORF021 of Bacteriophage ROSA [Bacteriophage phiNM4] YP_001331334.1 identical to ORF036 of Bacteriophage ROSA [Bacteriophage phiNM4] YP_001331335.1 similar to ORF124 of Bacteriophage ROSA [Bacteriophage phiNM4] YP_001331336.1 tape measure protein for bacteriophage phiNM4 YP_001331337.1 identical to ORF039 of Bacteriophage ROSA [Bacteriophage phiNM4] YP_001331338.1 minor structural protein for bacteriophage phiNM4 YP_001331339.1 similar to ORF002 of Bacteriophage ROSA [Bacteriophage phiNM4] YP_001331340.1 identical to ORF005 of Bacteriophage 92 [Bacteriophage phiNM4] YP_001331341.1 similar to ORF036 of Bacteriophage 55 [Bacteriophage phiNM4] YP_001331342.1 identical to ORF049 of Bacteriophage 55 [Bacteriophage phiNM4] YP_001331343.1 N-acetylglucosamidase for bacteriophage phiNM4 YP_001331344.1 tail fiber for bacteriophage phiNM4 YP_001331345.1 similar to orf 63 of phi ETA [Bacteriophage phiNM4] YP_001331346.1 holin for bacteriophage phiNM4 YP_001331347.1 phage amidase for bacteriophage phiNM4 YP_001331348.1 similar to functionally unknown protein YP_001331350.1 similar to bacterial luciferase family protein YP_001331351.1 similar to glycine cleavage H-protein YP_001331352.1 similar to functionally unknown protein YP_001331353.1 similar to functionally unknown protein YP_001331356.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_001331357.1 similar to PTS system component YP_001331358.1 similar to PTS transport system IIA component YP_001331359.1 similar to PTS multidomain regulator YP_001331362.1 similar to functionally unknown protein YP_001331367.1 similar to functionally unknown protein YP_001331368.1 similar to functionally unknown protein YP_001331369.1 similar to ribosomal protein-serine acetyltransferase YP_001331370.1 similar to functionally unknown protein YP_001331371.1 similar to functionally unknown protein YP_001331372.1 similar to functionally unknown protein YP_001331373.1 similar to functionally unknown protein YP_001331375.1 similar to functionally unknown protein YP_001331376.1 similar to functionally unknown protein YP_001331378.1 similar to functionally unknown protein YP_001331379.1 similar to functionally unknown protein YP_001331381.1 similar to functionally unknown protein YP_001331382.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_001331383.1 catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions YP_001331386.1 similar to functionally unknown protein YP_001331388.1 similar to functionally unknown protein YP_001331389.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001331390.1 similar to functionally unknown protein YP_001331391.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001331393.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001331394.1 similar to functionally unknown protein YP_001331395.1 similar to integrase YP_001331396.1 similar to functionally unknown protein YP_001331397.1 similar to functionally unknown protein YP_001331398.1 similar to functionally unknown protein YP_001331399.1 similar to functionally unknown protein YP_001331400.1 similar to functionally unknown protein YP_001331402.1 similar to functionally unknown protein YP_001331403.1 similar to functionally unknown protein YP_001331404.1 similar to functionally unknown protein YP_001331409.1 similar to functionally unknown protein YP_001331410.1 similar to functionally unknown protein YP_001331411.1 similar to functionally unknown protein YP_001331412.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine YP_001331415.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001331416.1 similar to functionally unknown protein YP_001331417.1 similar to functionally unknown protein YP_001331419.1 similar to functionally unknown protein YP_001331420.1 similar to functionally unknown protein YP_001331421.1 similar to functionally unknown protein YP_001331422.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_001331423.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_001331424.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_001331425.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_001331426.1 SSL5, SET3, SET10; bind P-selectin glycoprotein ligand-1 and inhibit P-selectin-mediated neutrophil rolling along the endothelium; these proteins share structural homology to known superantigens but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_001331427.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_001331428.1 SSL7, SET1; blocks IgA-FcR interactions and inhibits complement, leading to increased survival of a sensitive bacterium in blood YP_001331429.2 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_001331430.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_001331431.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_001331434.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_001331435.1 similar to functionally unknown protein YP_001331436.1 similar to functionally unknown protein YP_001331447.1 similar to functionally unknown protein YP_001331448.1 similar to functionally unknown protein YP_001331449.1 similar to functionally unknown protein YP_001331450.1 similar to functionally unknown protein YP_001331452.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_001331453.1 similar to functionally unknown protein YP_001331454.1 similar to functionally unknown protein YP_001331455.1 similar to PA-phosphatase related phosphoesterase YP_001331456.1 similar to functionally unknown protein YP_001331458.1 cystathionine beta-synthase YP_001331464.1 similar to functionally unknown protein YP_001331466.1 similar to acetyltransferase, GNAT family protein YP_001331467.1 similar to functionally unknown protein YP_001331468.1 similar to functionally unknown protein YP_001331471.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_001331477.1 similar to functionally unknown protein YP_001331478.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001331479.1 similar to ornithine/arginine/lysine decarboxylase YP_001331480.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_001331481.1 similar to functionally unknown protein YP_001331483.1 similar to functionally unknown protein YP_001331484.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA YP_001331485.1 similar to small methyltransferase YP_001331486.1 similar to tetrapyrrole (corrin/porphyrin) methylase YP_001331487.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001331489.1 similar to functionally unknown protein YP_001331490.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001331492.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001331494.1 similar to translation initiation inhibitor YP_001331495.1 stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus YP_001331496.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001331497.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001331498.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001331499.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001331501.1 similar to polysaccharide biosynthesis protein YP_001331502.1 similar to tetrapyrrole (corrin/porphyrin) methylases YP_001331508.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_001331509.1 cystathionine beta-synthase YP_001331513.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001331515.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_001331516.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_001331522.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001331523.1 rho motif-related TRAM YP_001331524.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001331526.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001331527.1 similar to functionally unknown protein YP_001331528.1 similar to SpoU rRNA Methylase YP_001331529.1 similar to functionally unknown protein YP_001331530.1 similar to functionally unknown protein YP_001331531.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001331533.1 binds directly to 23S ribosomal RNA YP_001331534.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001331535.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001331536.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001331537.1 similar to small methyltransferase YP_001331538.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001331539.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001331540.1 in Bacillus subtilis this non-essential protein associates with the ribosome YP_001331541.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001331542.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001331543.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001331544.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001331545.1 similar to peptidase YP_001331546.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_001331547.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress YP_001331548.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate YP_001331549.1 NAD-dependent epimerase/dehydratase YP_001331550.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001331552.1 similar to deoxynucleoside kinase YP_001331554.1 similar to cytosine deaminase YP_001331556.1 similar to functionally unknown protein YP_001331560.1 similar to poly (glycerol-phosphate) alpha-glucosyltransferase YP_001331562.1 similar to functionally unknown protein YP_001331563.1 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis YP_001331564.1 similar to functionally unknown protein YP_001331565.1 similar to functionally unknown protein YP_001331567.1 similar to hexulose-6-phosphate synthase YP_001331568.1 similar to 6-phospho-3-hexuloisomerase YP_001331569.1 similar to haloacid dehalogenase-like hydrolase YP_001331570.1 similar to glycine betaine/L-proline ABC transporter permease YP_001331571.1 similar to functionally unknown protein YP_001331572.1 Acyl-CoA synthetase YP_001331574.1 similar to functionally unknown protein YP_001331575.1 similar to functionally unknown protein YP_001331576.1 similar to functionally unknown protein YP_001331578.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_001331579.1 similar to functionally unknown protein YP_001331580.1 similar to functionally unknown protein YP_001331581.1 similar to transporter permease subunit YP_001331582.1 similar to functionally unknown protein YP_001331583.1 similar to functionally unknown protein YP_001331584.1 similar to functionally unknown protein YP_001331585.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_001331590.1 similar to functionally unknown protein YP_001331592.1 similar to DNA-binding protein YP_001331593.1 similar to functionally unknown protein YP_001331594.1 similar to functionally unknown protein YP_001331595.1 similar to functionally unknown protein YP_001331596.1 similar to functionally unknown protein YP_001331597.1 similar to functionally unknown protein YP_001331598.1 similar to functionally unknown protein YP_001331599.1 similar to functionally unknown protein YP_001331600.1 similar to functionally unknown protein YP_001331601.1 similar to functionally unknown protein YP_001331602.1 similar to functionally unknown protein YP_001331603.1 similar to functionally unknown protein YP_001331604.1 similar to functionally unknown protein YP_001331605.1 similar to functionally unknown protein YP_001331607.1 similar to functionally unknown protein YP_001331609.1 similar to metal-dependent phosphohydrolase, HD subdomain YP_001331610.1 similar to functionally unknown protein YP_001331611.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs YP_001331612.1 similar to functionally unknown protein YP_001331613.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001331614.1 similar to endonuclease III YP_001331617.1 similar to haloacid dehalogenase-like hydrolase YP_001331618.1 alpha/beta hydrolase fold family protein YP_001331619.1 similar to functionally unknown protein YP_001331620.1 similar to functionally unknown protein YP_001331621.1 similar to esterase/lipase YP_001331623.1 similar to functionally unknown protein YP_001331624.1 similar to functionally unknown protein YP_001331625.1 similar to functionally unknown protein YP_001331626.1 phage integrase family protein YP_001331627.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001331628.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001331629.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001331630.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; in S. meliloti it is known to be involved specifically with K+ transport YP_001331631.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_001331632.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001331633.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001331634.1 similar to Na+/H+ antiporter component YP_001331635.1 similar to ABC transporter substrate-binding protein YP_001331636.1 similar to cation ABC transporter permease YP_001331639.1 similar to functionally unknown protein YP_001331640.1 N-acetylglucosaminyldiphospho-undecaprenol N-acetyl-beta-D-mannosaminyltransferase; N-acetylmannosaminyltransferase; UDP-N-acetylmannosamine transferase YP_001331641.1 with TagG is involved in the export of teichoic acids YP_001331643.1 CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase YP_001331648.1 similar to pyrimidine nucleoside transporter YP_001331649.1 similar to functionally unknown protein YP_001331653.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase YP_001331654.1 similar to dihydroxyacetone kinase YP_001331655.1 similar to functionally unknown protein YP_001331656.1 similar to functionally unknown protein YP_001331657.1 similar to branched-chain amino acid transport system II carrier protein YP_001331659.1 similar to functionally unknown protein YP_001331660.1 similar to acetyltransferase, GNAT family protein YP_001331661.1 similar to functionally unknown protein YP_001331663.1 similar to sensor histidine kinase YP_001331666.1 similar to functionally unknown protein YP_001331667.1 similar to low-affinity inorganic phosphate transporter YP_001331669.1 similar to functionally unknown protein YP_001331672.1 similar to functionally unknown protein YP_001331673.1 similar to functionally unknown protein YP_001331674.1 similar to functionally unknown protein YP_001331675.1 similar to transcriptional regulator, LysR family YP_001331676.1 similar to sugar efflux transporter YP_001331677.1 similar to functionally unknown protein YP_001331678.1 similar to functionally unknown protein YP_001331679.1 similar to acetyltransferase, GNAT family protein YP_001331680.1 similar to functionally unknown protein YP_001331681.1 similar to functionally unknown protein YP_001331682.1 similar to acetyltransferase, GNAT family protein YP_001331683.1 similar to lysine decarboxylase family YP_001331684.1 similar to functionally unknown protein YP_001331685.1 similar to functionally unknown protein YP_001331686.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_001331691.1 aldo/keto reductase family protein YP_001331692.1 similar to functionally unknown protein YP_001331694.1 similar to deoxyribodipyrimidine photolyase YP_001331695.1 similar to functionally unknown protein YP_001331696.1 similar to functionally unknown protein YP_001331697.1 similar to functionally unknown protein YP_001331699.1 similar to functionally unknown protein YP_001331700.1 similar to functionally unknown protein YP_001331705.1 similar to functionally unknown protein YP_001331707.1 similar to glycosyl transferase, group 2 family protein YP_001331710.1 similar to functionally unknown protein YP_001331711.1 similar to functionally unknown protein YP_001331712.1 similar to functionally unknown protein YP_001331713.1 similar to radical activating enzyme protein YP_001331715.1 similar to functionally unknown protein YP_001331716.1 glutamine amidotransferase YP_001331719.1 similar to urea amidolyase YP_001331721.1 similar to sulfatase YP_001331726.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001331727.1 similar to 5'(3')-deoxyribonucleotidase YP_001331728.1 similar to functionally unknown protein YP_001331729.1 similar to multidrug resistance protein YP_001331731.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis YP_001331732.1 similar to multidrug resistance protein YP_001331733.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_001331734.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001331735.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_001331740.1 similar to mitochondrial intermembrane space protein, first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complex YP_001331741.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001331742.1 similar to functionally unknown protein YP_001331743.1 similar to functionally unknown protein YP_001331744.1 similar to functionally unknown protein YP_001331745.1 similar to glycerate kinase YP_001331746.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_001331747.1 similar to functionally unknown protein YP_001331748.1 similar to functionally unknown protein YP_001331751.1 similar to functionally unknown protein YP_001331752.1 similar to functionally unknown protein YP_001331753.1 similar to comF operon protein 1 YP_001331754.1 similar to comF operon protein 3 YP_001331755.1 ribosomal protein S30EA YP_001331756.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001331757.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_001331758.1 similar to a protein with LysM domain YP_001331759.1 similar to functionally unknown protein YP_001331760.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001331761.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001331762.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system YP_001331763.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001331764.1 similar to acetyltransferase YP_001331767.1 similar to functionally unknown protein YP_001331768.1 similar to functionally unknown protein YP_001331769.1 similar to functionally unknown protein YP_001331770.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001331771.1 similar to functionally unknown protein YP_001331772.1 similar to functionally unknown protein YP_001331773.1 similar to functionally unknown protein YP_001331776.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001331777.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_001331778.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_001331779.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001331780.1 similar to functionally unknown protein YP_001331782.1 similar to carboxylesterase YP_001331784.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001331785.1 similar to functionally unknown protein YP_001331786.1 similar to functionally unknown protein YP_001331787.1 similar to functionally unknown protein YP_001331788.1 similar to functionally unknown protein YP_001331789.1 similar to functionally unknown protein YP_001331790.1 fibrinogen-binding protein A YP_001331793.1 similar to functionally unknown protein YP_001331796.1 similar to functionally unknown protein YP_001331797.1 similar to functionally unknown protein YP_001331798.1 similar to functionally unknown protein YP_001331799.1 similar to functionally unknown protein YP_001331800.1 similar to functionally unknown protein YP_001331801.1 similar to functionally unknown protein YP_001331802.1 similar to phosphoglycerate mutase YP_001331803.1 similar to transporter LysE family YP_001331804.1 similar to acetyltransferase, GNAT family protein YP_001331806.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis YP_001331808.1 similar to thioredoxin YP_001331809.1 similar to arsenate reductase YP_001331810.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_001331811.1 similar to functionally unknown protein YP_001331812.1 similar to functionally unknown protein YP_001331813.1 similar to thioredoxin YP_001331818.1 similar to functionally unknown protein YP_001331824.1 similar to functionally unknown protein YP_001331825.1 similar to functionally unknown protein YP_001331826.1 similar to oxidoreductase, 2-nitropropane dioxygenase family YP_001331827.1 similar to functionally unknown protein YP_001331828.1 similar to functionally unknown protein YP_001331829.1 similar to 5'-nucleotidase YP_001331830.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001331831.1 similar to functionally unknown protein YP_001331832.1 similar to functionally unknown protein YP_001331833.1 similar to functionally unknown protein YP_001331834.1 haloacid dehalogenase-like family protein YP_001331836.1 similar to functionally unknown protein YP_001331837.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid YP_001331838.1 transporter YP_001331839.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid YP_001331841.1 similar to functionally unknown protein YP_001331842.1 similar to functionally unknown protein YP_001331843.1 similar to pyridine nucleotide-disulphide oxidoreductase YP_001331844.1 similar to functionally unknown protein YP_001331845.1 similar to pyridine nucleotide-disulphide YP_001331848.1 similar to functionally unknown protein YP_001331849.1 similar to functionally unknown protein YP_001331850.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001331851.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001331852.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001331853.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_001331854.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001331855.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in the case of S. meliloti it was proved to be involved specifically with K+ transport YP_001331856.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001331857.1 similar to functionally unknown protein YP_001331859.1 similar to S1 RNA binding domain protein YP_001331863.1 no similarity YP_001331865.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001331866.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_001331867.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001331868.1 similar to functionally unknown protein YP_001331874.1 similar to functionally unknown protein YP_001331875.1 NADPH-dependent; catalyzes the reduction of coenzyme A disulfide YP_001331876.1 similar to haloacid dehalogenase-like hydrolase YP_001331877.1 similar to functionally unknown protein YP_001331878.1 similar to lipopolysaccharide modification acyltransferase YP_001331881.1 similar to 2-isopropylmalate synthase YP_001331882.1 similar to functionally unknown protein YP_001331883.1 similar to functionally unknown protein YP_001331884.1 similar to functionally unknown protein YP_001331886.1 similar to functionally unknown protein YP_001331887.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001331889.1 similar to functionally unknown protein YP_001331894.1 similar to oligopeptide ABC transporter substrate-binding protein YP_001331896.1 similar to oligopeptide ABC transporter ATP-binding protein YP_001331898.1 similar to oligopeptide ABC transporter permease protein YP_001331900.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001331901.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress YP_001331902.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence YP_001331903.1 similar to competence protein CoiA YP_001331905.1 no similarity YP_001331908.1 similar to functionally unknown protein YP_001331909.1 similar to functionally unknown protein YP_001331911.1 catalyzes the phosphorylation of NAD to NADP YP_001331915.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001331916.1 similar to functionally unknown protein YP_001331918.1 similar to functionally unknown protein YP_001331919.1 similar to 2'-5' RNA ligase YP_001331920.1 similar to transporter protein YP_001331921.1 processive; catalyzes the formation of mono-, di- and tri-glucosyldiacylglycerol by the progressive transfer of glucosyl residues to diacylglycerol; involved in the formation of membrane glycolipids YP_001331922.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine YP_001331923.1 similar to functionally unknown protein YP_001331924.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_001331925.1 similar to toxic anion resistance membrane protein YP_001331930.1 similar to functionally unknown protein YP_001331932.1 similar to functionally unknown protein YP_001331933.1 similar to functionally unknown protein YP_001331934.1 no similarity YP_001331935.1 similar to functionally unknown protein YP_001331936.1 similar to functionally unknown protein YP_001331937.1 similar to ABC transporter ATP-binding protein YP_001331938.1 similar to functionally unknown protein YP_001331939.1 similar to functionally unknown protein YP_001331941.1 similar to functionally unknown protein YP_001331942.1 similar to ferrichrome ABC transporter YP_001331943.1 similar to functionally unknown protein YP_001331944.1 similar to functionally unknown protein YP_001331945.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_001331946.1 similar to menaquinone-specific isochorismate YP_001331947.1 2-oxoglutarate decarboxylase (menaquinone biosynthesis protein) YP_001331948.1 similar to menaquinone biosynthesis related protein YP_001331949.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_001331954.1 similar to functionally unknown protein YP_001331956.1 N-acetylmuramoyl-L-alanine amidase and mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase YP_001331958.1 similar to functionally unknown protein YP_001331959.1 similar to cell envelope-related transcriptional attenuator YP_001331965.1 similar to chitinase YP_001331966.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001331968.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_001331969.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001331970.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001331971.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001331972.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001331973.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001331975.1 involved in de novo purine biosynthesis YP_001331976.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001331977.1 similar to cobalt transport protein YP_001331978.1 similar to ABC transporter ATP-binding protein YP_001331979.1 similar to functionally unknown protein YP_001331980.1 similar to functionally unknown protein YP_001331981.1 similar to functionally unknown protein YP_001331982.1 similar to functionally unknown protein YP_001331988.1 similar to potassium transport protein YP_001331989.1 similar to functionally unknown protein YP_001331990.1 similar to Zn-dependent hydrolase YP_001331991.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001331992.1 similar to functionally unknown protein YP_001331996.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001331997.1 similar to functionally unknown protein YP_001331998.1 similar to transcriptional regulator Cro/CI family YP_001332003.1 similar to unknown membrane protein YP_001332004.1 similar to functionally unknown protein YP_001332006.1 similar to functionally unknown protein YP_001332009.1 similar to functionally unknown protein YP_001332010.1 similar to functionally unknown protein YP_001332011.1 depletion of this protein in Bacillus subtilis results in defects in cell morphology; crystal structure of Staphylococcus protein shows homodimer; putative ligand binding protein YP_001332012.1 FtsW/RodA/SpoVE family protein YP_001332013.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_001332015.1 converts protoheme IX and farnesyl diphosphate to heme O YP_001332016.1 similar to functionally unknown protein YP_001332017.1 similar to functionally unknown protein YP_001332018.1 similar to glycerophosphoryl diester phosphodiesterase YP_001332019.1 similar to functionally unknown protein YP_001332020.1 similar to functionally unknown protein YP_001332021.1 similar to methylase YP_001332022.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001332023.2 similar to functionally unknown protein YP_001332024.1 similar to functionally unknown protein YP_001332025.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001332026.1 integrase for bacteriophage phiNM2 YP_001332027.1 similar to ORF013 of Bacteriophage 53 [Bacteriophage phiNM2] YP_001332028.1 cI-like repressor for bacteriophage phiNM2 YP_001332029.1 anti-repressor protein for bacteriophage phiNM2 YP_001332030.1 similar to ORF046 Bacteriophage 52A [Bacteriophage phiNM2] YP_001332031.1 similar to functinally unknown protein [Bacteriophage phiNM2] YP_001332032.1 similar to ORF027 of Bacteriophage 55 [Bacteriophage phiNM2] YP_001332033.1 similar to ORF017 of Bacteriophage 55 [Bacteriophage phiNM2] YP_001332034.1 similar to ORF022 of Bacteriophage 77 [Bacteriophage phiNM2] YP_001332035.1 identical to ORF018 of Bacteriophage 77 [Bacteriophage phiNM2] YP_001332036.1 identical to ORF013 of Bacteriophage 92 [Bacteriophage phiNM2] YP_001332037.1 identical to ORF019 of Bacteriophage 53 [Bacteriophage phiNM2] YP_001332038.1 identical to ORF018 of Bacteriophage 53 [Bacteriophage phiNM2] YP_001332039.1 endodeoxyribonuclease for bacteriophage phiNM2 YP_001332040.1 identical to ORF038 of Bacteriophage ROSA [Bacteriophage phiNM2] YP_001332041.1 identical to ORF062 of Bacteriophage ROSA [Bacteriophage phiNM2] YP_001332042.1 identical to ORF061 of Bacteriophage ROSA [Bacteriophage phiNM2] YP_001332043.1 similar to ORF032 of Bacteriophage 53 [Bacteriophage phiNM2] YP_001332044.1 similar to functionally unknown protein [Bacteriophage phiNM2] YP_001332045.1 similar to ORF31 of bacteriophage phi ETA [Bacteriophage phiNM2] YP_001332046.1 similar to phi ETA orf 34-like protein of Staphylococcus aureus phage phi 13 [Bacteriophage phiNM2] YP_001332047.1 transcriptional activator for bacteriophage phiNM2 YP_001332048.1 terminase small subunit for bacteriophage phiNM2 YP_001332049.1 terminase large subunit for bacteriophage phiNM2 YP_001332050.1 portal protein for bacteriophage phiNM2 YP_001332051.1 head morphogenesis protein for bacteriophage phiNM2 YP_001332052.1 identical to SAV0890 of Bacteriophage phi mu1 [Bacteriophage phiNM2] YP_001332053.1 head protein for bacteriophage phiNM2 YP_001332054.1 identical to ORF059 of Bacteriophage 85 [Bacteriophage phiNM2] YP_001332055.1 similar to ORF059 of Bacteriophage 85 [Bacteriophage phiNM2] YP_001332056.1 identical to SAV0895 of Bacteriophage phi mu1 [Bacteriophage phiNM2] YP_001332057.1 identical to ORF047 of Bacteriophage 85 [Bacteriophage phiNM2] YP_001332058.1 similar to ORF041 of Bacteriophage 85 [Bacteriophage phiNM2] YP_001332059.1 major tail protein for bacteriophage phiNM2 YP_001332060.1 identical to ORF040 of Bacteriophage 53 [Bacteriophage phiNM2] YP_001332061.1 identical to ORF048 of Bacteriophage 85 [Bacteriophage phiNM2] YP_001332062.1 tape measure protein for bacteriophage phiNM2 YP_001332063.1 similar to ORF012 of Bacteriophage 69 [Bacteriophage phiNM2] YP_001332064.1 identical to phi ETA orf 55-like protein of Staphylococcus aureus phage phi 11 [Bacteriophage phiNM2] YP_001332065.1 similar to phi ETA orf 56-like protein of Staphylococcus aureus phage phi 11 [Bacteriophage phiNM2] YP_001332066.1 similar to ORF005 of Bacteriophage 29 [Bacteriophage phiNM2] YP_001332067.1 similar to ORF039 of Bacteriophage 92 [Bacteriophage phiNM2] YP_001332068.1 similar to ORF049 of Bacteriophage 55 [Bacteriophage phiNM2] YP_001332069.1 N-acetylglucosamidase for bacteriophage phiNM2 YP_001332070.1 tail fiber for bacteriophage phiNM2 YP_001332071.1 similar to phi ETA orf 63-like protein [Bacteriophage phiNM2] YP_001332072.1 holin for bacteriophage phiNM2 YP_001332073.1 amidase for bacteriophage phiNM2 YP_001332081.1 iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source YP_001332083.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001332084.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001332085.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_001332086.1 no similarity YP_001332087.1 similar to functionally unknown protein YP_001332088.1 similar to bacteriocin biosynthesis protein YP_001332090.1 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange YP_001332092.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001332093.1 no similarity YP_001332095.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001332096.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_001332097.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_001332098.1 hydrolyzes non-standard nucleotides such as xanthine and inosine YP_001332099.1 similar to functionally unknown protein YP_001332100.1 similar to fibrinogen-binding protein YP_001332101.1 FLIPr; secreted protein that blocks the formyl peptide receptor-like 1 (FPRL1) found in neutrophils, monocytes, B cells, and NK cells; inhibits the binding of chemoattractants (such as formylated peptides) to FPRL1, which initiates the phagocyte mobilization towards the infection site YP_001332102.1 similar to functionally unknown protein YP_001332103.1 similar to fibrinogen-binding protein YP_001332104.1 similar to fibrinogen-binding protein YP_001332105.1 similar to functionally unknown protein YP_001332106.1 similar to functionally unknown protein YP_001332108.1 similar to functionally unknown protein YP_001332109.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_001332110.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_001332111.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_001332112.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_001332113.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_001332115.1 similar to functionally unknown protein YP_001332119.1 similar to functionally unknown protein YP_001332121.1 similar to functionally unknown protein YP_001332122.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001332126.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001332127.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001332130.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001332131.1 similar to functionally unknown protein YP_001332132.1 similar to functionally unknown protein YP_001332133.1 similar to functionally unknown protein YP_001332134.1 similar to functionally unknown protein YP_001332135.1 similar to RNA-binding S4 YP_001332136.1 similar to cell-division initiation protein YP_001332137.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_001332138.1 no similarity YP_001332139.1 bleomycin resistance protein; dioxygenase superfamily YP_001332141.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001332143.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_001332145.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001332146.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001332147.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001332148.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001332149.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_001332150.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001332151.1 similar to functionally unknown protein YP_001332152.1 similar to functionally unknown protein YP_001332153.1 similar to fibronectin/fibrinogen-binding protein YP_001332154.1 Essential for recycling GMP and indirectly, cGMP YP_001332155.1 phosphopantothenate-cysteine ligase YP_001332157.1 similar to functionally unknown protein YP_001332158.1 similar to functionally unknown protein YP_001332159.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001332161.1 similar to RNA-binding Sun protein YP_001332162.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_001332163.1 similar to protein phosphatase 2C domain protein YP_001332165.1 similar to GTPase engC family YP_001332168.1 required for 70S ribosome assembly YP_001332169.1 similar to functionally unknown protein YP_001332171.1 catalyzes branch migration in Holliday junction intermediates YP_001332172.1 negative regulator of genes involved in fatty acid and phospholipid biosynthesis for gram positive bacteria YP_001332173.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_001332176.1 carries the fatty acid chain in fatty acid biosynthesis YP_001332177.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_001332180.1 similar to DNA-binding protein YP_001332182.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001332183.1 Essential for efficient processing of 16S rRNA YP_001332184.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001332185.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001332186.1 similar to functionally unknown protein YP_001332187.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) YP_001332188.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001332189.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001332190.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_001332192.1 endopeptidase resistance gene YP_001332193.1 similar to DNA processing protein DprA/Smf YP_001332194.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001332195.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine YP_001332197.1 heat shock protein involved in degradation of misfolded proteins YP_001332198.1 heat shock protein involved in degradation of misfolded proteins YP_001332199.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor YP_001332200.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001332201.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001332202.1 Catalyzes the phosphorylation of UMP to UDP YP_001332203.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001332204.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_001332206.1 similar to membrane-associated zinc metalloprotease YP_001332207.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001332208.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity YP_001332209.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001332210.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001332212.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001332213.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001332214.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001332216.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001332221.1 similar to functionally unknown protein YP_001332223.1 similar to acetoacetyl-CoA reductase YP_001332224.1 similar to functionally unknown protein YP_001332228.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001332229.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP YP_001332230.1 similar to functionally unknown protein YP_001332231.1 similar to functionally unknown protein YP_001332233.1 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin YP_001332234.1 similar to functionally unknown protein YP_001332235.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001332236.1 similar to functionally unknown protein YP_001332237.1 similar to functionally unknown protein YP_001332238.1 This protein performs the mismatch recognition step during the DNA repair process YP_001332239.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001332242.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_001332244.1 alpha/beta hydrolase fold family protein YP_001332245.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001332247.1 similar to glutathione peroxidase YP_001332248.1 similar to GTP-binding protein proteinase modulator YnbA YP_001332249.1 similar to aluminium resistance protein YP_001332252.1 similar to functionally unknown protein YP_001332253.1 similar to functionally unknown protein YP_001332254.1 similar to functionally unknown protein YP_001332255.1 similar to functionally unknown protein YP_001332256.1 similar to functionally unknown protein YP_001332257.1 similar to functionally unknown protein YP_001332258.1 similar to functionally unknown protein YP_001332259.1 similar to functionally unknown protein YP_001332260.1 similar to functionally unknown protein YP_001332261.1 similar to functionally unknown protein YP_001332262.1 threonine aldolase YP_001332263.1 similar to functionally unknown protein YP_001332264.1 D/Transphosphatidylase YP_001332269.1 similar to functionally unknown protein YP_001332271.1 similar to functionally unknown protein YP_001332272.1 similar to functionally unknown protein YP_001332273.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive YP_001332274.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_001332275.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001332276.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_001332278.1 similar to functionally unknown protein YP_001332281.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001332282.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001332284.1 similar to functionally unknown protein YP_001332285.1 Represses a number of genes involved in the response to DNA damage YP_001332286.1 similar to functionally unknown protein YP_001332287.1 similar to functionally unknown protein YP_001332289.1 similar to functionally unknown protein YP_001332290.1 similar to functionally unknown protein YP_001332293.1 similar to functionally unknown protein YP_001332294.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_001332296.1 similar to functionally unknown protein YP_001332297.1 Catalyzes the conversion of citrate to isocitrate YP_001332299.1 similar to functionally unknown protein YP_001332300.1 similar to functionally unknown protein YP_001332301.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001332302.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001332305.1 similar to functionally unknown protein YP_001332307.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_001332311.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate YP_001332312.1 similar to glutamyl aminopeptidase YP_001332313.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_001332315.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001332316.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_001332317.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis YP_001332318.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001332319.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001332322.1 similar to functionally unknown protein YP_001332323.1 similar to functionally unknown protein YP_001332328.1 similar to functionally unknown protein YP_001332331.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001332336.1 similar to functionally unknown protein YP_001332338.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_001332340.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001332341.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001332346.1 similar to functionally unknown protein YP_001332348.1 similar to functionally unknown protein YP_001332349.1 catalyzes the hydrolysis of acylphosphate YP_001332350.1 similar to 5-bromo-4-chloroindolyl phosphate hydrolysis protein XpaC YP_001332351.1 similar to tellurite resistance protein YP_001332356.1 similar to nitric-oxide reductase YP_001332357.1 similar to functionally unknown protein YP_001332358.1 similar to functionally unknown protein YP_001332359.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_001332360.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001332363.1 similar to functionally unknown protein YP_001332364.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001332368.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_001332369.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_001332370.1 similar to functionally unknown protein YP_001332372.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_001332373.1 similar to functionally unknown protein YP_001332374.1 similar to functionally unknown protein YP_001332375.1 similar to functionally unknown protein YP_001332376.1 similar to functionally unknown protein YP_001332377.1 similar to cell wall enzyme EbsB YP_001332379.1 similar to cell wall associated fibronectin-binding protein YP_001332380.1 similar to membrane efflux protein YP_001332382.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic YP_001332384.1 similar to 5'-3' exonuclease YP_001332385.1 similar to functionally unknown protein YP_001332386.1 similar to functionally unknown protein YP_001332387.1 similar to functionally unknown protein YP_001332388.1 similar to methyltransferase YP_001332389.1 similar to functionally unknown protein YP_001332390.1 similar to functionally unknown protein YP_001332391.1 similar to functionally unknown protein YP_001332392.1 similar to functionally unknown protein YP_001332393.1 similar to functionally unknown protein YP_001332394.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC YP_001332396.1 similar to functionally unknown protein YP_001332397.1 similar to endonuclease III YP_001332399.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001332400.1 DinG family helicase YP_001332401.1 biotin operon repressor and biotin-[acetyl-CoA}-carboxylase synthetase YP_001332402.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity YP_001332405.1 similar to functionally unknown protein YP_001332406.1 similar to functionally unknown protein YP_001332407.1 similar to functionally unknown protein YP_001332408.1 similar to functionally unknown protein YP_001332409.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001332410.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001332411.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001332412.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001332414.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_001332415.1 similar to functionally unknown protein YP_001332417.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001332418.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001332419.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001332420.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001332424.1 similar to ATP-dependent DNA helicase RecQ YP_001332425.1 similar to functionally unknown protein YP_001332427.1 similar to functionally unknown protein YP_001332428.1 similar to functionally unknown protein YP_001332429.1 similar to functionally unknown protein YP_001332430.1 similar to functionally unknown protein YP_001332431.1 similar to functionally unknown protein YP_001332432.1 similar to functionally unknown protein YP_001332436.1 similar to functionally unknown protein YP_001332437.1 similar to functionally unknown protein YP_001332438.1 similar to functionally unknown protein YP_001332445.1 similar to ribonuclease Z YP_001332446.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001332451.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_001332453.1 similar to functionally unknown protein YP_001332454.1 similar to functionally unknown protein YP_001332455.1 dihydrolipoamide acetyltransferase YP_001332460.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_001332462.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001332463.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001332464.1 similar to functionally unknown protein YP_001332465.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001332467.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001332468.1 Xaa-Pro dipeptidase YP_001332469.1 similar to functionally unknown protein YP_001332470.1 similar to functionally unknown protein YP_001332472.1 similar to functionally unknown protein YP_001332473.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein YP_001332474.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein YP_001332475.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001332476.1 similar to shikimate kinase YP_001332477.1 similar to ComG operon competence protein YP_001332478.1 similar to functionally unknown protein YP_001332479.1 similar to competence protein ComG YP_001332484.1 similar to functionally unknown protein YP_001332488.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001332494.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_001332496.1 similar to functionally unknown protein YP_001332497.1 similar to functionally unknown protein YP_001332498.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium YP_001332500.1 similar to functionally unknown protein YP_001332502.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001332504.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001332507.1 similar to functionally unknown protein YP_001332509.1 similar to functionally unknown protein YP_001332510.1 similar to functionally unknown protein YP_001332511.1 similar to functionally unknown protein YP_001332512.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001332513.1 similar to functionally unknown protein YP_001332514.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001332515.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_001332516.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001332517.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001332518.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_001332520.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001332521.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001332522.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001332523.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_001332527.1 similar to functionally unknown protein YP_001332528.1 similar to functionally unknown protein YP_001332529.1 similar to functionally unknown protein YP_001332531.1 similar to functionally unknown protein YP_001332533.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis YP_001332536.1 similar to functionally unknown protein YP_001332538.1 similar to functionally unknown protein YP_001332539.1 similar to functionally unknown protein YP_001332544.1 similar to allophanate hydrolase subunit 1 YP_001332545.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001332546.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_001332550.1 similar to functionally unknown protein YP_001332551.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001332552.1 similar to functionally unknown protein YP_001332553.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001332555.1 similar to functionally unknown protein YP_001332556.1 no similarity YP_001332557.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001332560.1 no similarity YP_001332561.1 similar to functionally unknown protein YP_001332562.1 similar to functionally unknown protein YP_001332565.1 similar to functionally unknown protein YP_001332566.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001332567.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001332569.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001332571.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001332573.1 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001332575.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001332576.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001332577.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001332578.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001332580.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001332581.1 involved in the peptidyltransferase reaction during translation YP_001332582.1 similar to functionally unknown protein YP_001332585.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001332586.1 similar to functionally unknown protein YP_001332587.1 similar to functionally unknown protein YP_001332588.1 similar to functionally unknown protein YP_001332589.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_001332592.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001332595.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_001332596.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001332598.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_001332600.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_001332601.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001332602.1 binds and unfolds substrates as part of the ClpXP protease YP_001332603.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001332604.1 similar to functionally unknown protein YP_001332606.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001332608.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_001332610.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_001332611.1 Primosomal protein that may act to load helicase DnaC during DNA replication YP_001332615.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_001332618.1 similar to functionally unknown protein YP_001332621.1 Converts isocitrate to alpha ketoglutarate YP_001332622.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate YP_001332627.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_001332628.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_001332629.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_001332635.1 catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins YP_001332636.1 Xaa-Pro dipeptidase homolog YP_001332639.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_001332640.1 similar to functionally unknown protein YP_001332641.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_001332642.1 similar to functionally unknown protein YP_001332643.1 Required for the synthesis of the thiazole moiety YP_001332645.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation YP_001332646.1 similar to functionally unknown protein YP_001332647.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001332651.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001332655.1 similar to serine proteinase YP_001332659.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_001332660.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_001332664.1 catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate YP_001332665.1 similar to functionally unknown protein YP_001332667.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001332669.1 similar to functionally unknown protein YP_001332670.1 similar to functionally unknown protein YP_001332674.1 similar to functionally unknown protein YP_001332675.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001332676.1 similar to aminoglycoside phosphotransferase YP_001332678.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases YP_001332679.1 similar to functionally unknown protein YP_001332682.1 similar to functionally unknown protein YP_001332683.1 similar to fmtB protein, cell wall anchored YP_001332684.1 similar to functionally unknown protein YP_001332685.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001332687.1 similar to functionally unknown protein YP_001332688.1 similar to SAM-dependent methyltransferase YP_001332691.1 similar to lysophospholipase YP_001332693.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001332694.1 3,4-dihydroxy-2-butanone-4-phosphate synthase; GTP cyclohydrolase II YP_001332695.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001332697.1 similar to functionally unknown protein YP_001332700.1 catalyzes the reduction of arsenate to arsenite; also can dephosphorylate tyrosine phosphorylated proteins, aryl phosphates, and acyl phosphates YP_001332702.1 similar to functionally unknown protein YP_001332703.1 similar to functionally unknown protein YP_001332704.1 similar to functionally unknown protein YP_001332706.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_001332707.1 similar to functionally unknown protein YP_001332708.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_001332712.1 aldo/keto reductase family protein YP_001332713.1 similar to functionally unknown protein YP_001332714.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001332715.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_001332716.1 IS200 family YP_001332717.1 similar to functionally unknown protein YP_001332721.1 similar to functionally unknown protein YP_001332722.1 similar to functionally unknown protein YP_001332723.1 similar to functionally unknown protein YP_001332724.1 similar to functionally unknown protein YP_001332725.1 similar to functionally unknown protein YP_001332726.1 similar to functionally unknown protein YP_001332727.1 similar to functionally unknown protein YP_001332728.1 similar to functionally unknown protein YP_001332730.1 similar to functionally unknown protein YP_001332731.1 similar to functionally unknown protein YP_001332732.1 similar to functionally unknown protein YP_001332741.1 no similarity YP_001332742.1 similar to functionally unknown protein YP_001332754.1 similar to functionally unknown protein YP_001332755.1 similar to functionally unknown protein YP_001332756.1 similar to functionally unknown protein YP_001332757.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX YP_001332758.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_001332759.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_001332761.1 similar to ABC transporter YP_001332762.1 similar to ABC transporter ATP-binding protein YP_001332764.1 similar to functionally unknown protein YP_001332765.1 similar to functionally unknown protein YP_001332766.1 similar to functionally unknown protein YP_001332768.1 catalyzes the exonucleic cleavage of mRNA yielding nucleioside 5'-phosphates YP_001332769.1 similar to functionally unknown protein YP_001332770.1 similar to DNA repair exonuclease YP_001332771.1 similar to functionally unknown protein YP_001332772.1 similar to functionally unknown protein YP_001332773.1 similar to DNA-binding protein YP_001332777.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001332778.1 similar to functionally unknown protein YP_001332779.1 similar to functionally unknown protein YP_001332780.1 similar to glucosamine-6-phosphate isomerase YP_001332782.1 similar to iron-sulfur cluster-binding protein YP_001332790.1 converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate YP_001332791.1 similar to functionally unknown protein YP_001332793.1 similar to functionally unknown protein YP_001332795.1 similar to functionally unknown protein YP_001332796.1 similar to functionally unknown protein YP_001332798.1 similar to functionally unknown protein YP_001332799.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_001332800.1 monofunctional; catalyzes the elongation of glycan strands in cell wall biosynthesis YP_001332802.1 similar to functionally unknown protein YP_001332803.1 amidase for bacteriophage phiNM1 YP_001332804.1 holin for bacteriophage phiNM1 YP_001332805.1 similar to phi ETA orf 63-like protein [Bacteriophage phiNM1] YP_001332806.1 tail fiber for bacteriophage phiNM1 YP_001332807.1 N-acetylglucosamidase for bacteriophage phiNM1 YP_001332808.1 similar to ORF049 of Bacteriophage 55 [Bacteriophage phiNM1] YP_001332809.1 similar to ORF039 of Bacteriophage 92 [Bacteriophage phiNM1] YP_001332810.1 similar to ORF005 of Bacteriophage 29 [Bacteriophage phiNM1] YP_001332811.1 similar to phi ETA orf 56-like protein of Staphylococcus aureus phage phi 11 [Bacteriophage phiNM1] YP_001332812.1 identical to phi ETA orf 55-like protein of Staphylococcus aureus phage phi 11 [Bacteriophage phiNM1] YP_001332813.1 identical to ORF012 of Bacteriophage 53 [Bacteriophage phiNM1] YP_001332814.1 tape measure protein for bacteriophage phiNM1 YP_001332815.1 identical to ORF048 of Bacteriophage 85 [Bacteriophage phiNM1] YP_001332816.1 identical to ORF044 of Bacteriophage 85 [Bacteriophage phiNM1] YP_001332817.1 major tail protein for bacteriophage phiNM1 YP_001332818.1 identical to ORF041 of Bacteriophage 85 [Bacteriophage phiNM1] YP_001332819.1 identical to ORF047 of Bacteriophage 85 [Bacteriophage phiNM1] YP_001332820.1 identical to SAV0895 of Bacteriophage phi mu1 [Bacteriophage phiNM1] YP_001332821.1 identical to ORF049 of Bacteriophage 85 [Bacteriophage phiNM1] YP_001332822.1 identical to ORF059 of Bacteriophage 85 [Bacteriophage phiNM1] YP_001332823.1 head protein for bacteriophage phiNM1 YP_001332824.1 similar to SAV0890 of Bacteriophage phi mu1 [Bacteriophage phiNM1] YP_001332825.1 head morphogenesis protein for bacteriophage phiNM1 YP_001332826.1 portal protein for bacteriophage phiNM1 YP_001332827.1 terminase large subunit for bacteriophage phiNM1 YP_001332828.1 terminase small subunit for bacteriophage phiNM1 YP_001332829.1 phage transcriptional activator for bacteriophage phiNM1 YP_001332830.1 similar to phi ETA orf 34-like protein of Staphylococcus aureus phage phi 13 [Bacteriophage phiNM1] YP_001332831.1 similar to ORF31 of bacteriophage phi ETA [Bacteriophage phiNM1] YP_001332832.1 similar to functionally unknonw protein [Bacteriophage phiNM1] YP_001332833.1 similar to ORF032 of Bacteriophage 53 [Bacteriophage phiNM1] YP_001332834.1 identical to ORF061 of Bacteriophage ROSA [Bacteriophage phiNM1] YP_001332835.1 identical to ORF062 of Bacteriophage ROSA [Bacteriophage phiNM1] YP_001332836.1 identical to ORF038 of Bacteriophage ROSA [Bacteriophage phiNM1] YP_001332837.1 endodeoxyribonuclease for bacteriophage phiNM1 YP_001332838.1 identical to ORF018 of Bacteriophage 53 [Bacteriophage phiNM1] YP_001332839.1 identical to ORF019 of Bacteriophage 53 [Bacteriophage phiNM1] YP_001332840.1 identical to ORF013 of Bacteriophage 92 [Bacteriophage phiNM1] YP_001332841.1 identical to ORF018 of Bacteriophage 77 [Bacteriophage phiNM1] YP_001332842.1 identical to ORF022 of Bacteriophage 77 [Bacteriophage phiNM1] YP_001332843.1 identical to ORF012 of Bacteriophage 77 [Bacteriophage phiNM1] YP_001332844.1 identical to ORF043 of Bacteriophage 77 [Bacteriophage phiNM1] YP_001332845.1 anti-repressor for bacteriophage phiNM1 YP_001332846.1 repressor for bacteriophage phiNM1 YP_001332847.1 identical to ORF013 of Bacteriophage 53 [Bacteriophage phiNM1] YP_001332848.1 integrase for bacteriophage phiNM1 YP_001332849.1 similar to functionally unknown protein YP_001332852.1 similar to functionally unknown protein YP_001332854.1 similar to functionally unknown protein YP_001332856.1 involved in vancomycin resistance YP_001332857.1 involved in vancomycin resistance YP_001332858.1 similar to functionally unknown protein YP_001332859.1 similar to functionally unknown protein YP_001332860.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_001332861.1 similar to functionally unknown protein YP_001332862.1 similar to functionally unknown protein YP_001332864.1 Mur ligase YP_001332867.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001332868.1 similar to functionally unknown protein YP_001332870.1 similar to YegS from E. coli YP_001332871.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001332872.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001332873.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_001332878.1 PcrB-like protein; GGGP synthase; member of prenyltransferases that transfer isoprenoid groups to nonisoprenoid acceptors; functions in form GGGP from glycerol-1-phosphate (G-1-P) and geranylgeranyl pyrophosphate (GGPP); important in lipid metabolism and especially important as the ether linkages in archaea are different than those in bacteria; GGGP synthase lies at the branch point for membrane lipid biosynthesis; cytosolic; T acidophilum protein acts as a homodimer while M thermoautotrophicum protein has been reported to function as a pentamer YP_001332879.1 similar to functionally unknown protein YP_001332880.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001332882.1 similar to functionally unknown protein YP_001332883.1 similar to functionally unknown protein YP_001332884.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_001332885.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_001332888.1 huNaDC-1 YP_001332889.1 similar to functionally unknown protein YP_001332891.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_001332893.1 similar to functionally unknown protein YP_001332894.1 similar to functionally unknown protein YP_001332895.1 similar to functionally unknown protein YP_001332897.1 similar to functionally unknown protein YP_001332898.1 similar to functionally unknown protein YP_001332899.1 similar to functionally unknown protein YP_001332902.1 similar to functionally unknown protein YP_001332908.1 similar to functionally unknown protein [Bacteriophage phiNM3] YP_001332909.1 similar to functionally unknown protein [Bacteriophage phiNM3] YP_001332910.1 encoded in bacteriophage phiNM3 YP_001332911.1 secreted protein that specifically inhibits the activation of neutrophils and monocytes by binding to the formylated peptide receptor and the C5a receptor; blocks neutrophil migration towards the infection site and hinders the establishment of the initial defense against the infection YP_001332912.1 encoded in bacteriophage phiNM3 YP_001332913.1 encoded in bacteriophage phiNM3 YP_001332914.1 encoded in bacteriophage phiNM3 YP_001332915.1 amidase for bacteriophage phiNM3 YP_001332916.1 holin for bacteriophage phiNM3 YP_001332917.1 encoded in bacteriophage phiNM3 YP_001332918.1 similar to functionally unknown protein [Bacteriophage phiNM3] YP_001332919.1 identical to orf 22 of Staphylococcus aureus bacteriophage PVL [Bacteriophage phiNM3] YP_001332920.1 minor structural protein for bacteriophage phiNM3 YP_001332921.1 tail fiber protein for bacteriophage phiNM3 YP_001332922.1 tail tape measure protein for bacteriophage phiNM3 YP_001332923.1 identical to ORF034 of Bacteriophage 77 [Bacteriophage phiNM3] YP_001332924.1 major tail protein for bacteriophage phiNM3 YP_001332925.1 identical to ORF027 of Bacteriophage 77 [Bacteriophage phiNM3] YP_001332926.1 identical to SA1770 of S. aureus phage phiN315 [Bacteriophage phiNM3] YP_001332927.1 head-tail adaptor for bacteriophage phiNM3 YP_001332928.1 identical to ORF042 of Bacteriophage 77 [Bacteriophage phiNM3] YP_001332929.1 identical to SA1773 of S. aureus phage phiN315 [Bacteriophage phiNM3] YP_001332930.1 major capsid protein for bacteriophage phiNM3 YP_001332931.1 Clp-like protease for bacteriophage phiNM3 YP_001332932.1 portal protein for bacteriophage phiNM3 YP_001332933.1 terminase large subunit for bacteriophage phiNM3 YP_001332934.1 identical to ORF037 of Bacteriophage 77 [Bacteriophage phiNM3] YP_001332935.1 HNH endonuclease for bacteriophage phiNM3 YP_001332936.1 transcriptional activator for bacteriophage phiNM3 YP_001332937.1 similar to ORF36 of bacteriophage phi ETA [Bacteriophage phiNM3] YP_001332938.1 dUTP pyrophosphatase for bacteriophage phiNM3 YP_001332939.1 similar to SAR2074 of Staphylococcus aureus subsp. aureus MRSA252 [Bacteriophage phiNM3] YP_001332940.1 identical to SAR2077 of Staphylococcus aureus subsp. aureus MRSA252 [Bacteriophage phiNM3] YP_001332941.1 endodeoxyribonuclease for bacteriophage phiNM3 YP_001332942.1 regulatory protein for bacteriophage phiNM3 YP_001332943.1 single-strand DNA-binding protein for bacteriophage phiNM3 YP_001332944.1 identical to SAR2084 of Staphylococcus aureus subsp. aureus MRSA252 [Bacteriophage phiNM3] YP_001332945.1 identical to SAR2085 of Staphylococcus aureus subsp. aureus MRSA252 [Bacteriophage phiNM3] YP_001332946.1 identical to SAR2086 of Staphylococcus aureus subsp. aureus MRSA252 [Bacteriophage phiNM3] YP_001332947.1 identical to SAR2087 of Staphylococcus aureus subsp. aureus MRSA252 [Bacteriophage phiNM3] YP_001332948.1 similar to SAR2088 of Staphylococcus aureus subsp. aureus MRSA252 [Bacteriophage phiNM3] YP_001332949.1 similar to SAR2089 of Staphylococcus aureus subsp. aureus MRSA252 [Bacteriophage phiNM3] YP_001332950.1 identical to SAR2092 of Staphylococcus aureus subsp. aureus MRSA252 [Bacteriophage phiNM3] YP_001332951.1 similar to SAR2093 of Staphylococcus aureus subsp. aureus MRSA252 [Bacteriophage phiNM3] YP_001332952.1 anti repressor for bacteriophage phiNM3 YP_001332953.1 identical to SAR2097 of Staphylococcus aureus subsp. aureus MRSA252 [Bacteriophage phiNM3] YP_001332954.1 transcriptional regulator for bacteriophage phiNM3 YP_001332955.1 cI-like repressor for bacteriophage phiNM3 YP_001332956.1 exonuclease for bacteriophage phiNM3 YP_001332957.1 identical to SAR2102 of Staphylococcus aureus subsp. aureus MRSA252 [Bacteriophage phiNM3] YP_001332958.1 identical to SAR2104 of Staphylococcus aureus subsp. aureus MRSA252 [Bacteriophage phiNM3] YP_001332959.1 integrase for bacteriophage phiNM3 YP_001332963.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001332964.1 similar to tetracenomycin polyketide synthesis O-methyltransferase YP_001332966.1 similar to cation transport protein YP_001332968.1 similar to functionally unknown protein YP_001332971.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001332972.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001332973.1 similar to functionally unknown protein YP_001332975.1 similar to nitroreductase family protein YP_001332976.1 carbon-nitrogen family protein YP_001332981.1 similar to fructokinase YP_001332985.1 similar to functionally unknown protein YP_001332986.1 similar to functionally unknown protein YP_001332987.1 modulates transcription in response to the NADH/NAD(+) redox state YP_001332990.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001332993.1 similar to functionally unknown protein YP_001332994.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001332996.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001332997.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_001332998.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001332999.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001333000.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_001333001.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic YP_001333004.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation; induced by heat shock, salt stress, oxidative stress, glucose limitation, oxygen limitation and entry into stationary phase YP_001333005.1 binds to sigma-B preventing the formation of an RNA polymerase holoenzyme YP_001333010.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001333011.1 similar to functionally unknown protein YP_001333012.1 similar to functionally unknown protein YP_001333013.1 similar to functionally unknown protein YP_001333014.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex YP_001333015.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001333016.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001333021.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001333022.1 FtsW/RodA/SpoVE family protein YP_001333023.1 similar to functionally unknown protein YP_001333024.1 similar to functionally unknown protein YP_001333025.1 similar to functionally unknown protein YP_001333027.1 similar to functionally unknown protein YP_001333029.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_001333030.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_001333031.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_001333033.1 similar to functionally unknown protein YP_001333034.1 no similarity YP_001333035.1 similar to single strand DNA binding protein YP_001333036.1 similar to functionally unknown protein YP_001333037.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001333038.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001333039.1 similar to functionally unknown protein YP_001333040.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_001333041.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001333042.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001333043.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001333044.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001333045.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit B is part of the membrane proton channel YP_001333046.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001333047.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001333048.1 similar to functionally unknown protein YP_001333050.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001333051.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001333052.1 similar to functionally unknown protein YP_001333056.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001333057.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_001333058.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001333059.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001333061.1 similar to functionally unknown protein YP_001333062.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001333063.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; induced by anaerobic conditions in Bacillus subtilis YP_001333064.1 similar to functionally unknown protein YP_001333065.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001333066.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling YP_001333068.1 catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type II pantothenate kinases are not regulated by feedback inhibition by coenzyme A YP_001333069.1 similar to functionally unknown protein YP_001333070.1 similar to functionally unknown protein YP_001333071.1 similar to aminobenzoyl-glutamate utilization protein B YP_001333072.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_001333073.1 similar to functionally unknown protein YP_001333074.1 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway YP_001333075.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_001333076.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_001333077.1 similar to non-heme iron-containing ferritin YP_001333079.1 similar to functionally unknown protein YP_001333080.1 similar to functionally unknown protein YP_001333082.1 similar to functionally unknown protein YP_001333090.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001333092.1 DNA-binding protein YP_001333095.1 Mrp, SasB YP_001333096.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001333097.1 similar to functionally unknown protein YP_001333098.1 similar to functionally unknown protein YP_001333103.1 similar to functionally unknown protein YP_001333104.1 similar to transporter YP_001333106.1 similar to UDP-N-acetylglucosamine pyrophosphorylase YP_001333107.1 similar to functionally unknown protein YP_001333108.1 similar to functionally unknown protein YP_001333109.1 similar to functionally unknown protein YP_001333113.1 similar to functionally unknown protein YP_001333115.1 similar to functionally unknown protein YP_001333121.1 similar to functionally unknown protein YP_001333122.1 similar to functionally unknown protein YP_001333123.1 BCCT family, opuD-like protein YP_001333124.1 similar to Zinc-type alcohol dehydrogenase YP_001333125.1 similar to quinone oxidoreductase YP_001333126.1 similar to functionally unknown protein YP_001333127.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside YP_001333130.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources YP_001333131.1 catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP YP_001333132.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate YP_001333133.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization YP_001333135.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_001333136.1 similar to functionally unknown protein YP_001333137.1 similar to functionally unknown protein YP_001333145.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase YP_001333146.1 similar to functionally unknown protein YP_001333147.1 similar to functionally unknown protein YP_001333148.1 similar to functionally unknown protein YP_001333149.1 similar to functionally unknown protein YP_001333150.1 similar to functionally unknown protein YP_001333151.1 similar to functionally unknown protein YP_001333152.1 similar to functionally unknown protein YP_001333153.1 forms a direct contact with the tRNA during translation YP_001333154.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001333155.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001333156.1 similar to cobalt transport protein YP_001333157.1 with CbiNQ forms the ABC transporter for cobalt import; Staphylococcus has two adjacent copies of this gene YP_001333158.1 with CbiNQ forms the ABC transporter for cobalt import; Staphylococcus has two adjacent copies of this gene YP_001333159.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001333160.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001333161.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001333162.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001333163.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_001333164.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001333165.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001333166.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001333167.1 late assembly protein YP_001333168.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001333169.1 truncated; located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001333170.1 binds 5S rRNA along with protein L5 and L25 YP_001333171.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001333172.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001333173.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_001333174.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001333175.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001333176.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001333177.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001333178.1 one of the stabilizing components for the large ribosomal subunit YP_001333179.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001333180.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001333181.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001333182.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001333183.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001333184.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001333185.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001333186.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001333187.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_001333188.1 similar to functionally unknown protein YP_001333190.1 decatenates replicating daughter chromosomes YP_001333193.1 similar to functionally unknown protein YP_001333194.1 similar to functionally unknown protein YP_001333195.1 similar to functionally unknown protein YP_001333197.1 related to methicillin resistance YP_001333198.1 similar to functionally unknown protein YP_001333200.1 similar to transporter protein YP_001333203.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_001333208.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_001333214.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_001333218.1 no similarity YP_001333221.1 similar to transporter protein YP_001333222.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_001333223.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Staphylococcus saprophyticus plays a role in bladder invasiveness and may induce the formation of kidney and bladder stones due to the alkalization of urine YP_001333224.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_001333225.1 involved in the assembly of the urease metallocenter; possible nickel donor YP_001333230.1 similar to functionally unknown protein YP_001333236.1 similar to functionally unknown protein YP_001333238.1 similar to functionally unknown protein YP_001333242.1 no similarity YP_001333243.1 similar to functionally unknown protein YP_001333249.1 similar to functionally unknown protein YP_001333250.1 similar to functionally unknown protein YP_001333252.1 similar to amino acid permease YP_001333253.1 similar to functionally unknown protein YP_001333254.1 similar to functionally unknown protein YP_001333257.1 similar to functionally unknown protein YP_001333258.1 PTS system, glucose-like IIB component YP_001333260.1 similar to functionally unknown protein YP_001333262.1 similar to functionally unknown protein YP_001333265.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_001333266.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_001333268.1 catalyzes resistance to fosfomycin by the addition of a thiol cofactor YP_001333269.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate YP_001333271.1 catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_001333272.1 similar to functionally unknown protein YP_001333274.1 similar to functionally unknown protein YP_001333275.1 similar to functionally unknown protein YP_001333277.1 similar to functionally unknown protein YP_001333278.1 similar to functionally unknown protein YP_001333281.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate YP_001333283.1 similar to functionally unknown protein YP_001333284.1 similar to functionally unknown protein YP_001333286.1 similar to functionally unknown protein YP_001333288.1 similar to multidrug resistance protein A YP_001333293.1 similar to functionally unknown protein YP_001333296.1 similar to ABC transporter permease YP_001333299.1 similar to functionally unknown protein YP_001333300.1 similar to functionally unknown protein YP_001333301.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_001333303.1 similar to functionally unknown protein YP_001333304.1 similar to functionally unknown protein YP_001333309.1 similar to functionally unknown protein YP_001333310.1 similar to functionally unknown protein YP_001333314.1 similar to functionally unknown protein YP_001333316.1 similar to functionally unknown protein YP_001333317.1 similar to functionally unknown protein YP_001333319.1 similar to functionally unknown protein YP_001333323.1 similar to functionally unknown protein YP_001333327.1 similar to functionally unknown protein YP_001333338.1 similar to functionally unknown protein YP_001333339.1 similar to functionally unknown protein YP_001333343.1 similar to functionally unknown protein YP_001333349.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_001333356.1 catalyzes the formation of pimeloyl-CoA from pimelate and coenzyme A YP_001333358.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine YP_001333363.1 similar to functionally unknown protein YP_001333364.1 similar to functionally unknown protein YP_001333366.1 similar to functionally unknown protein YP_001333368.1 similar to functionally unknown protein YP_001333369.1 similar to functionally unknown protein YP_001333373.1 similar to amino acid permease YP_001333376.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_001333382.1 similar to functionally unknown protein YP_001333383.1 similar to amino acid permease YP_001333386.1 similar to functionally unknown protein YP_001333390.1 similar to functionally unknown protein YP_001333392.1 similar to functionally unknown protein YP_001333393.1 similar to transporter YP_001333399.1 similar to functionally unknown protein YP_001333400.1 similar to functionally unknown protein YP_001333401.1 similar to functionally unknown protein YP_001333402.1 similar to functionally unknown protein YP_001333404.1 similar to transport protein YP_001333406.1 similar to functionally unknown protein YP_001333407.1 similar to functionally unknown protein YP_001333408.1 similar to functionally unknown protein YP_001333409.1 short-chain dehydrogenase/reductase SDR YP_001333410.1 similar to functionally unknown protein YP_001333411.1 similar to functionally unknown protein YP_001333412.1 similar to functionally unknown protein YP_001333413.1 similar to functionally unknown protein YP_001333414.1 similar to functionally unknown protein YP_001333415.1 similar to functionally unknown protein YP_001333416.1 similar to functionally unknown protein YP_001333417.1 similar to functionally unknown protein YP_001333418.1 similar to functionally unknown protein YP_001333419.1 similar to functionally unknown protein YP_001333420.1 similar to helicase YP_001333421.1 MutT/nudix family protein YP_001333423.1 similar to functionally unknown protein YP_001333424.1 similar to functionally unknown protein YP_001333425.1 similar to transporter permease YP_001333426.1 similar to functionally unknown protein YP_001333434.1 similar to functionally unknown protein YP_001333439.1 similar to functionally unknown protein YP_001333440.1 similar to functionally unknown protein YP_001333441.1 similar to functionally unknown protein YP_001333442.1 similar to transporter protein YP_001333447.1 similar to functionally unknown protein YP_001333449.1 similar to functionally unknown protein YP_001333451.1 similar to glyoxylase family protein YP_001333454.1 dioxygenase; glyoxalase YP_001333456.1 catalyzes the formation of pyruvate from lactate YP_001333457.1 haloacid dehalogenase-like family protein YP_001333459.1 similar to functionally unknown protein YP_001333462.1 similar to functionally unknown protein YP_001333465.1 similar to perfringolysin O regulator protein YP_001333466.1 similar to functionally unknown protein YP_001333467.1 similar to functionally unknown protein YP_001333468.1 similar to functionally unknown protein YP_001333469.1 similar to functionally unknown protein YP_001333470.1 similar to functionally unknown protein YP_001333472.1 catalyzes the formation of acetyl phosphate from pyruvate YP_001333476.1 similar to functionally unknown protein YP_001333478.1 similar to functionally unknown protein YP_001333483.1 similar to functionally unknown protein YP_001333486.1 similar to functionally unknown protein YP_001333487.1 similar to functionally unknown protein YP_001333488.1 catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate YP_001333490.1 similar to functionally unknown protein YP_001333493.1 catalyzes the formation of pyruvate from lactate YP_001333499.1 similar to functionally unknown protein YP_001333504.1 similar to regulatory protein YP_001333506.1 similar to functionally unknown protein YP_001333507.1 similar to functionally unknown protein YP_001333509.1 similar to functionally unknown protein YP_001333510.1 similar to functionally unknown protein YP_001333512.1 short chain dehydrogenase/reductase family protein YP_001333514.1 alpha/beta hydrolase fold family protein YP_001333515.1 P47K family protein YP_001333516.1 similar to functionally unknown protein YP_001333517.1 FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001333518.1 similar to functionally unknown protein YP_001333519.1 similar to functionally unknown protein YP_001333520.1 similar to functionally unknown protein YP_001333522.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001333523.1 similar to functionally unknown protein YP_001333524.1 similar to functionally unknown protein YP_001333525.1 similar to functionally unknown protein YP_001333528.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_001333529.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_001333530.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001333535.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_001333536.1 similar to functionally unknown protein YP_001333537.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis YP_001333538.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_001333539.1 similar to functionally unknown protein YP_001333540.1 similar to acetate-CoA ligase YP_001333541.1 similar to antibiotic biosynthesis monooxygenase YP_001333542.1 similar to functionally unknown protein YP_001333543.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_001333545.1 similar to functionally unknown protein YP_001333549.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_001333550.1 similar to citrate transporter permease YP_001333551.1 catalyzes the formation of siroheme from precorrin-2 YP_001333554.1 similar to functionally unknown protein YP_001333559.1 no similarity YP_001333561.1 similar to transcriptional regulator YP_001333565.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_001333567.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_001333568.1 catalyzes the degradation of arginine to citruline and ammonia YP_001333572.1 similar to functionally unknown protein YP_001333576.1 similar to phage infection protein YP_001333579.1 similar to functionally unknown protein YP_001333580.1 similar to functionally unknown protein YP_001333582.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins YP_001333586.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001333587.1 similar to functionally unknown protein YP_001333588.1 similar to functionally unknown protein YP_001333589.1 similar to functionally unknown protein YP_001333590.1 similar to functionally unknown protein YP_001333591.1 similar to functionally unknown protein YP_001333592.1 similar to functionally unknown protein YP_001333593.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; a fusion protein of this enzyme with MsrB provides protection against oxidative stress in Neisseria gonorrhoeae YP_001333599.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein YP_001333604.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_001333605.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001333606.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-hosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_001333607.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001333608.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_001333610.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001333611.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_001333612.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_001333613.1 similar to functionally unknown protein YP_001333614.1 similar to functionally unknown protein YP_001333617.1 similar to functionally unknown protein YP_001333618.1 similar to functionally unknown protein YP_001333619.1 similar to functionally unknown protein YP_001333621.1 similar to rhodanese family protein YP_001333622.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline YP_001333623.1 similar to functionally unknown protein YP_001333625.1 similar to functionally unknown protein YP_001333628.1 similar to functionally unknown protein YP_001333631.1 similar to functionally unknown protein YP_001333634.1 similar to functionally unknown protein YP_001333635.1 recombinase YP_001333636.1 similar to functionally unknown protein YP_001333637.1 recombinase, core domain family YP_001333638.1 similar to functionally unknown protein YP_001333640.1 similar to functionally unknown protein YP_001333641.1 similar to functionally unknown protein YP_001333642.1 similar to functionally unknown protein YP_001333644.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001333645.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001333646.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001333647.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_001333648.1 in Escherichia coli transcription of this gene is enhanced by polyamines