-- dump date 20140620_074642 -- class Genbank::misc_feature -- table misc_feature_note -- id note 426430000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 426430000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 426430000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430000004 Walker A motif; other site 426430000005 ATP binding site [chemical binding]; other site 426430000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 426430000007 Walker B motif; other site 426430000008 arginine finger; other site 426430000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 426430000010 DnaA box-binding interface [nucleotide binding]; other site 426430000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 426430000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 426430000013 putative DNA binding surface [nucleotide binding]; other site 426430000014 dimer interface [polypeptide binding]; other site 426430000015 beta-clamp/clamp loader binding surface; other site 426430000016 beta-clamp/translesion DNA polymerase binding surface; other site 426430000017 recF protein; Region: recf; TIGR00611 426430000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 426430000019 Walker A/P-loop; other site 426430000020 ATP binding site [chemical binding]; other site 426430000021 Q-loop/lid; other site 426430000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426430000023 ABC transporter signature motif; other site 426430000024 Walker B; other site 426430000025 D-loop; other site 426430000026 H-loop/switch region; other site 426430000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 426430000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430000029 Mg2+ binding site [ion binding]; other site 426430000030 G-X-G motif; other site 426430000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 426430000032 anchoring element; other site 426430000033 dimer interface [polypeptide binding]; other site 426430000034 ATP binding site [chemical binding]; other site 426430000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 426430000036 active site 426430000037 putative metal-binding site [ion binding]; other site 426430000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 426430000039 DNA gyrase subunit A; Validated; Region: PRK05560 426430000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 426430000041 CAP-like domain; other site 426430000042 active site 426430000043 primary dimer interface [polypeptide binding]; other site 426430000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426430000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426430000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426430000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426430000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426430000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426430000050 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 426430000051 putative substrate binding site [chemical binding]; other site 426430000052 putative ATP binding site [chemical binding]; other site 426430000053 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 426430000054 active sites [active] 426430000055 tetramer interface [polypeptide binding]; other site 426430000056 seryl-tRNA synthetase; Provisional; Region: PRK05431 426430000057 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 426430000058 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 426430000059 dimer interface [polypeptide binding]; other site 426430000060 active site 426430000061 motif 1; other site 426430000062 motif 2; other site 426430000063 motif 3; other site 426430000064 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 426430000065 Predicted membrane protein [Function unknown]; Region: COG4392 426430000066 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 426430000067 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 426430000068 Predicted membrane protein [Function unknown]; Region: COG4241 426430000069 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 426430000070 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 426430000071 DHH family; Region: DHH; pfam01368 426430000072 DHHA1 domain; Region: DHHA1; pfam02272 426430000073 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 426430000074 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 426430000075 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 426430000076 replicative DNA helicase; Region: DnaB; TIGR00665 426430000077 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 426430000078 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 426430000079 Walker A motif; other site 426430000080 ATP binding site [chemical binding]; other site 426430000081 Walker B motif; other site 426430000082 DNA binding loops [nucleotide binding] 426430000083 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 426430000084 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 426430000085 GDP-binding site [chemical binding]; other site 426430000086 ACT binding site; other site 426430000087 IMP binding site; other site 426430000088 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426430000089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430000090 active site 426430000091 phosphorylation site [posttranslational modification] 426430000092 intermolecular recognition site; other site 426430000093 dimerization interface [polypeptide binding]; other site 426430000094 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426430000095 DNA binding site [nucleotide binding] 426430000096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 426430000097 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426430000098 dimerization interface [polypeptide binding]; other site 426430000099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426430000100 putative active site [active] 426430000101 heme pocket [chemical binding]; other site 426430000102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426430000103 dimer interface [polypeptide binding]; other site 426430000104 phosphorylation site [posttranslational modification] 426430000105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430000106 ATP binding site [chemical binding]; other site 426430000107 Mg2+ binding site [ion binding]; other site 426430000108 G-X-G motif; other site 426430000109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 426430000110 YycH protein; Region: YycH; pfam07435 426430000111 YycH protein; Region: YycI; cl02015 426430000112 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 426430000113 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 426430000114 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 426430000115 putative active site [active] 426430000116 putative metal binding site [ion binding]; other site 426430000117 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 426430000118 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 426430000119 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 426430000120 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 426430000121 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 426430000122 phosphate binding site [ion binding]; other site 426430000123 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 426430000124 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 426430000125 active site residue [active] 426430000126 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 426430000127 CPxP motif; other site 426430000128 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 426430000129 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 426430000130 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 426430000131 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 426430000132 active site residue [active] 426430000133 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 426430000134 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 426430000135 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 426430000136 FMN binding site [chemical binding]; other site 426430000137 active site 426430000138 catalytic residues [active] 426430000139 substrate binding site [chemical binding]; other site 426430000140 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 426430000141 H+ Antiporter protein; Region: 2A0121; TIGR00900 426430000142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430000143 putative substrate translocation pore; other site 426430000144 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 426430000145 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426430000146 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426430000147 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426430000148 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426430000149 dimerization interface [polypeptide binding]; other site 426430000150 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426430000151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426430000152 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426430000153 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 426430000154 Part of AAA domain; Region: AAA_19; pfam13245 426430000155 AAA domain; Region: AAA_12; pfam13087 426430000156 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 426430000157 active site 426430000158 catalytic site [active] 426430000159 putative metal binding site [ion binding]; other site 426430000160 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430000161 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430000162 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430000163 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430000164 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 426430000165 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426430000166 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 426430000167 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 426430000168 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 426430000169 metal binding site [ion binding]; metal-binding site 426430000170 dimer interface [polypeptide binding]; other site 426430000171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430000172 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426430000173 putative substrate translocation pore; other site 426430000174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430000175 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 426430000176 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 426430000177 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 426430000178 PhoU domain; Region: PhoU; pfam01895 426430000179 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 426430000180 EamA-like transporter family; Region: EamA; pfam00892 426430000181 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 426430000182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426430000183 DNA-binding site [nucleotide binding]; DNA binding site 426430000184 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426430000185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430000186 homodimer interface [polypeptide binding]; other site 426430000187 catalytic residue [active] 426430000188 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 426430000189 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 426430000190 L-lactate permease; Region: Lactate_perm; cl00701 426430000191 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 426430000192 B domain; Region: B; pfam02216 426430000193 B domain; Region: B; pfam02216 426430000194 B domain; Region: B; pfam02216 426430000195 B domain; Region: B; pfam02216 426430000196 B domain; Region: B; pfam02216 426430000197 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 426430000198 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 426430000199 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426430000200 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 426430000201 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426430000202 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 426430000203 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426430000204 ABC-ATPase subunit interface; other site 426430000205 dimer interface [polypeptide binding]; other site 426430000206 putative PBP binding regions; other site 426430000207 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 426430000208 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426430000209 ABC-ATPase subunit interface; other site 426430000210 dimer interface [polypeptide binding]; other site 426430000211 putative PBP binding regions; other site 426430000212 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 426430000213 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 426430000214 siderophore binding site; other site 426430000215 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 426430000216 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 426430000217 dimer interface [polypeptide binding]; other site 426430000218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430000219 catalytic residue [active] 426430000220 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 426430000221 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 426430000222 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 426430000223 IucA / IucC family; Region: IucA_IucC; pfam04183 426430000224 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 426430000225 drug efflux system protein MdtG; Provisional; Region: PRK09874 426430000226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430000227 putative substrate translocation pore; other site 426430000228 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 426430000229 IucA / IucC family; Region: IucA_IucC; pfam04183 426430000230 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 426430000231 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 426430000232 IucA / IucC family; Region: IucA_IucC; pfam04183 426430000233 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 426430000234 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 426430000235 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 426430000236 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 426430000237 dimer interface [polypeptide binding]; other site 426430000238 active site 426430000239 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426430000240 catalytic residues [active] 426430000241 substrate binding site [chemical binding]; other site 426430000242 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 426430000243 ParB-like nuclease domain; Region: ParBc; pfam02195 426430000244 acetoin reductase; Validated; Region: PRK08643 426430000245 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 426430000246 NAD binding site [chemical binding]; other site 426430000247 homotetramer interface [polypeptide binding]; other site 426430000248 homodimer interface [polypeptide binding]; other site 426430000249 active site 426430000250 substrate binding site [chemical binding]; other site 426430000251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426430000252 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 426430000253 NAD(P) binding site [chemical binding]; other site 426430000254 active site 426430000255 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 426430000256 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426430000257 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 426430000258 putative ADP-binding pocket [chemical binding]; other site 426430000259 O-Antigen Polymerase; Region: Wzy_C; cl04850 426430000260 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 426430000261 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 426430000262 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 426430000263 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 426430000264 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 426430000265 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 426430000266 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426430000267 DNA-binding site [nucleotide binding]; DNA binding site 426430000268 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 426430000269 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 426430000270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426430000271 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 426430000272 intersubunit interface [polypeptide binding]; other site 426430000273 active site 426430000274 catalytic residue [active] 426430000275 phosphopentomutase; Provisional; Region: PRK05362 426430000276 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 426430000277 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 426430000278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430000279 dimer interface [polypeptide binding]; other site 426430000280 conserved gate region; other site 426430000281 putative PBP binding loops; other site 426430000282 ABC-ATPase subunit interface; other site 426430000283 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 426430000284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430000285 dimer interface [polypeptide binding]; other site 426430000286 conserved gate region; other site 426430000287 ABC-ATPase subunit interface; other site 426430000288 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 426430000289 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 426430000290 Walker A/P-loop; other site 426430000291 ATP binding site [chemical binding]; other site 426430000292 Q-loop/lid; other site 426430000293 ABC transporter signature motif; other site 426430000294 Walker B; other site 426430000295 D-loop; other site 426430000296 H-loop/switch region; other site 426430000297 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 426430000298 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 426430000299 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 426430000300 active site 426430000301 metal binding site [ion binding]; metal-binding site 426430000302 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 426430000303 Replication initiation factor; Region: Rep_trans; pfam02486 426430000304 Replication initiation factor; Region: Rep_trans; cl03616 426430000305 Transposase IS200 like; Region: Y1_Tnp; cl00848 426430000306 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 426430000307 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 426430000308 putative catalytic cysteine [active] 426430000309 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 426430000310 putative active site [active] 426430000311 metal binding site [ion binding]; metal-binding site 426430000312 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 426430000313 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 426430000314 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 426430000315 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426430000316 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 426430000317 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 426430000318 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 426430000319 NAD(P) binding site [chemical binding]; other site 426430000320 homodimer interface [polypeptide binding]; other site 426430000321 substrate binding site [chemical binding]; other site 426430000322 active site 426430000323 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 426430000324 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 426430000325 NAD(P) binding site [chemical binding]; other site 426430000326 homodimer interface [polypeptide binding]; other site 426430000327 substrate binding site [chemical binding]; other site 426430000328 active site 426430000329 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 426430000330 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 426430000331 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 426430000332 putative NAD(P) binding site [chemical binding]; other site 426430000333 active site 426430000334 putative substrate binding site [chemical binding]; other site 426430000335 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 426430000336 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 426430000337 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 426430000338 active site 426430000339 homodimer interface [polypeptide binding]; other site 426430000340 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 426430000341 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 426430000342 trimer interface [polypeptide binding]; other site 426430000343 active site 426430000344 substrate binding site [chemical binding]; other site 426430000345 CoA binding site [chemical binding]; other site 426430000346 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426430000347 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426430000348 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 426430000349 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426430000350 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 426430000351 Bacterial sugar transferase; Region: Bac_transf; pfam02397 426430000352 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 426430000353 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 426430000354 putative NAD(P) binding site [chemical binding]; other site 426430000355 active site 426430000356 putative substrate binding site [chemical binding]; other site 426430000357 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 426430000358 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 426430000359 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 426430000360 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 426430000361 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 426430000362 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 426430000363 active site 426430000364 homodimer interface [polypeptide binding]; other site 426430000365 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 426430000366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 426430000367 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 426430000368 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426430000369 NAD(P) binding site [chemical binding]; other site 426430000370 catalytic residues [active] 426430000371 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 426430000372 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 426430000373 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 426430000374 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426430000375 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426430000376 Walker A/P-loop; other site 426430000377 ATP binding site [chemical binding]; other site 426430000378 Q-loop/lid; other site 426430000379 ABC transporter signature motif; other site 426430000380 Walker B; other site 426430000381 D-loop; other site 426430000382 H-loop/switch region; other site 426430000383 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 426430000384 NMT1-like family; Region: NMT1_2; pfam13379 426430000385 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426430000386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 426430000387 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426430000388 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426430000389 active site 426430000390 Uncharacterized conserved protein [Function unknown]; Region: COG5609 426430000391 formate dehydrogenase; Provisional; Region: PRK07574 426430000392 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 426430000393 dimerization interface [polypeptide binding]; other site 426430000394 ligand binding site [chemical binding]; other site 426430000395 NAD binding site [chemical binding]; other site 426430000396 catalytic site [active] 426430000397 putative transporter; Provisional; Region: PRK10054 426430000398 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 426430000399 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 426430000400 acyl-activating enzyme (AAE) consensus motif; other site 426430000401 AMP binding site [chemical binding]; other site 426430000402 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 426430000403 Condensation domain; Region: Condensation; pfam00668 426430000404 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 426430000405 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 426430000406 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 426430000407 acyl-activating enzyme (AAE) consensus motif; other site 426430000408 AMP binding site [chemical binding]; other site 426430000409 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 426430000410 thioester reductase domain; Region: Thioester-redct; TIGR01746 426430000411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426430000412 NAD(P) binding site [chemical binding]; other site 426430000413 active site 426430000414 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 426430000415 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 426430000416 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 426430000417 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 426430000418 nucleotide binding site [chemical binding]; other site 426430000419 N-acetyl-L-glutamate binding site [chemical binding]; other site 426430000420 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 426430000421 heterotetramer interface [polypeptide binding]; other site 426430000422 active site pocket [active] 426430000423 cleavage site 426430000424 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 426430000425 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 426430000426 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 426430000427 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426430000428 inhibitor-cofactor binding pocket; inhibition site 426430000429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430000430 catalytic residue [active] 426430000431 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 426430000432 Isochorismatase family; Region: Isochorismatase; pfam00857 426430000433 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 426430000434 catalytic triad [active] 426430000435 conserved cis-peptide bond; other site 426430000436 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 426430000437 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 426430000438 dimer interface [polypeptide binding]; other site 426430000439 PYR/PP interface [polypeptide binding]; other site 426430000440 TPP binding site [chemical binding]; other site 426430000441 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426430000442 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 426430000443 TPP-binding site [chemical binding]; other site 426430000444 dimer interface [polypeptide binding]; other site 426430000445 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 426430000446 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 426430000447 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 426430000448 active site turn [active] 426430000449 phosphorylation site [posttranslational modification] 426430000450 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 426430000451 HPr interaction site; other site 426430000452 glycerol kinase (GK) interaction site [polypeptide binding]; other site 426430000453 active site 426430000454 phosphorylation site [posttranslational modification] 426430000455 Uncharacterized conserved protein [Function unknown]; Region: COG3589 426430000456 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 426430000457 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 426430000458 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 426430000459 putative active site [active] 426430000460 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 426430000461 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 426430000462 active site turn [active] 426430000463 phosphorylation site [posttranslational modification] 426430000464 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 426430000465 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 426430000466 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 426430000467 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 426430000468 putative active site [active] 426430000469 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 426430000470 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 426430000471 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426430000472 ATP binding site [chemical binding]; other site 426430000473 putative Mg++ binding site [ion binding]; other site 426430000474 RES domain; Region: RES; pfam08808 426430000475 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 426430000476 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426430000477 Walker A/P-loop; other site 426430000478 ATP binding site [chemical binding]; other site 426430000479 Q-loop/lid; other site 426430000480 ABC transporter signature motif; other site 426430000481 Walker B; other site 426430000482 D-loop; other site 426430000483 H-loop/switch region; other site 426430000484 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 426430000485 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426430000486 Walker A/P-loop; other site 426430000487 ATP binding site [chemical binding]; other site 426430000488 Q-loop/lid; other site 426430000489 ABC transporter signature motif; other site 426430000490 Walker B; other site 426430000491 D-loop; other site 426430000492 H-loop/switch region; other site 426430000493 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426430000494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430000495 dimer interface [polypeptide binding]; other site 426430000496 conserved gate region; other site 426430000497 putative PBP binding loops; other site 426430000498 ABC-ATPase subunit interface; other site 426430000499 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426430000500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430000501 dimer interface [polypeptide binding]; other site 426430000502 conserved gate region; other site 426430000503 ABC-ATPase subunit interface; other site 426430000504 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 426430000505 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 426430000506 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426430000507 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 426430000508 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 426430000509 Protein of unknown function, DUF576; Region: DUF576; cl04553 426430000510 azoreductase; Reviewed; Region: PRK00170 426430000511 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426430000512 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 426430000513 Peptidase family M23; Region: Peptidase_M23; pfam01551 426430000514 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 426430000515 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 426430000516 Walker A/P-loop; other site 426430000517 ATP binding site [chemical binding]; other site 426430000518 Q-loop/lid; other site 426430000519 ABC transporter signature motif; other site 426430000520 Walker B; other site 426430000521 D-loop; other site 426430000522 H-loop/switch region; other site 426430000523 TOBE domain; Region: TOBE; pfam03459 426430000524 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 426430000525 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 426430000526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430000527 dimer interface [polypeptide binding]; other site 426430000528 conserved gate region; other site 426430000529 ABC-ATPase subunit interface; other site 426430000530 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 426430000531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430000532 dimer interface [polypeptide binding]; other site 426430000533 conserved gate region; other site 426430000534 putative PBP binding loops; other site 426430000535 ABC-ATPase subunit interface; other site 426430000536 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 426430000537 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 426430000538 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 426430000539 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 426430000540 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 426430000541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 426430000542 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 426430000543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430000544 putative substrate translocation pore; other site 426430000545 Response regulator receiver domain; Region: Response_reg; pfam00072 426430000546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430000547 active site 426430000548 phosphorylation site [posttranslational modification] 426430000549 intermolecular recognition site; other site 426430000550 dimerization interface [polypeptide binding]; other site 426430000551 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426430000552 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426430000553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426430000554 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 426430000555 Histidine kinase; Region: His_kinase; pfam06580 426430000556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430000557 ATP binding site [chemical binding]; other site 426430000558 Mg2+ binding site [ion binding]; other site 426430000559 G-X-G motif; other site 426430000560 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 426430000561 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 426430000562 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 426430000563 Pyruvate formate lyase 1; Region: PFL1; cd01678 426430000564 coenzyme A binding site [chemical binding]; other site 426430000565 active site 426430000566 catalytic residues [active] 426430000567 glycine loop; other site 426430000568 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 426430000569 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426430000570 FeS/SAM binding site; other site 426430000571 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426430000572 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 426430000573 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 426430000574 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 426430000575 putative active site [active] 426430000576 catalytic site [active] 426430000577 putative metal binding site [ion binding]; other site 426430000578 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 426430000579 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 426430000580 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 426430000581 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 426430000582 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 426430000583 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 426430000584 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 426430000585 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 426430000586 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 426430000587 dimer interface [polypeptide binding]; other site 426430000588 active site 426430000589 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 426430000590 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 426430000591 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426430000592 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426430000593 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 426430000594 substrate binding site [chemical binding]; other site 426430000595 oxyanion hole (OAH) forming residues; other site 426430000596 trimer interface [polypeptide binding]; other site 426430000597 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426430000598 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426430000599 active site 426430000600 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 426430000601 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426430000602 acyl-activating enzyme (AAE) consensus motif; other site 426430000603 AMP binding site [chemical binding]; other site 426430000604 active site 426430000605 CoA binding site [chemical binding]; other site 426430000606 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 426430000607 Coenzyme A transferase; Region: CoA_trans; smart00882 426430000608 Coenzyme A transferase; Region: CoA_trans; cl17247 426430000609 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 426430000610 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 426430000611 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426430000612 Uncharacterized conserved protein [Function unknown]; Region: COG3189 426430000613 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 426430000614 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 426430000615 heme-binding site [chemical binding]; other site 426430000616 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 426430000617 FAD binding pocket [chemical binding]; other site 426430000618 FAD binding motif [chemical binding]; other site 426430000619 phosphate binding motif [ion binding]; other site 426430000620 beta-alpha-beta structure motif; other site 426430000621 NAD binding pocket [chemical binding]; other site 426430000622 Heme binding pocket [chemical binding]; other site 426430000623 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 426430000624 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 426430000625 tetramer (dimer of dimers) interface [polypeptide binding]; other site 426430000626 NAD binding site [chemical binding]; other site 426430000627 dimer interface [polypeptide binding]; other site 426430000628 substrate binding site [chemical binding]; other site 426430000629 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 426430000630 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 426430000631 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 426430000632 active site turn [active] 426430000633 phosphorylation site [posttranslational modification] 426430000634 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 426430000635 active site 426430000636 tetramer interface [polypeptide binding]; other site 426430000637 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 426430000638 Mga helix-turn-helix domain; Region: Mga; pfam05043 426430000639 PRD domain; Region: PRD; pfam00874 426430000640 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 426430000641 active site 426430000642 P-loop; other site 426430000643 phosphorylation site [posttranslational modification] 426430000644 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 426430000645 active site 426430000646 phosphorylation site [posttranslational modification] 426430000647 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 426430000648 active site 426430000649 phosphorylation site [posttranslational modification] 426430000650 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 426430000651 active site 426430000652 P-loop; other site 426430000653 phosphorylation site [posttranslational modification] 426430000654 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 426430000655 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 426430000656 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 426430000657 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 426430000658 putative NAD(P) binding site [chemical binding]; other site 426430000659 catalytic Zn binding site [ion binding]; other site 426430000660 structural Zn binding site [ion binding]; other site 426430000661 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 426430000662 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 426430000663 putative NAD(P) binding site [chemical binding]; other site 426430000664 catalytic Zn binding site [ion binding]; other site 426430000665 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 426430000666 substrate binding site; other site 426430000667 dimer interface; other site 426430000668 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 426430000669 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 426430000670 putative NAD(P) binding site [chemical binding]; other site 426430000671 putative catalytic Zn binding site [ion binding]; other site 426430000672 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 426430000673 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 426430000674 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 426430000675 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 426430000676 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 426430000677 substrate binding site; other site 426430000678 dimer interface; other site 426430000679 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 426430000680 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 426430000681 putative NAD(P) binding site [chemical binding]; other site 426430000682 putative catalytic Zn binding site [ion binding]; other site 426430000683 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 426430000684 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 426430000685 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426430000686 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426430000687 active site 426430000688 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 426430000689 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 426430000690 Hemerythrin-like domain; Region: Hr-like; cd12108 426430000691 Fe binding site [ion binding]; other site 426430000692 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 426430000693 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 426430000694 Histidine kinase; Region: His_kinase; pfam06580 426430000695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430000696 Mg2+ binding site [ion binding]; other site 426430000697 G-X-G motif; other site 426430000698 two-component response regulator; Provisional; Region: PRK14084 426430000699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430000700 active site 426430000701 phosphorylation site [posttranslational modification] 426430000702 intermolecular recognition site; other site 426430000703 dimerization interface [polypeptide binding]; other site 426430000704 LytTr DNA-binding domain; Region: LytTR; pfam04397 426430000705 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 426430000706 antiholin-like protein LrgB; Provisional; Region: PRK04288 426430000707 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 426430000708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426430000709 DNA-binding site [nucleotide binding]; DNA binding site 426430000710 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 426430000711 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 426430000712 active site turn [active] 426430000713 phosphorylation site [posttranslational modification] 426430000714 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 426430000715 HPr interaction site; other site 426430000716 glycerol kinase (GK) interaction site [polypeptide binding]; other site 426430000717 active site 426430000718 phosphorylation site [posttranslational modification] 426430000719 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 426430000720 beta-galactosidase; Region: BGL; TIGR03356 426430000721 Methyltransferase domain; Region: Methyltransf_31; pfam13847 426430000722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430000723 S-adenosylmethionine binding site [chemical binding]; other site 426430000724 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 426430000725 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 426430000726 substrate binding site [chemical binding]; other site 426430000727 dimer interface [polypeptide binding]; other site 426430000728 ATP binding site [chemical binding]; other site 426430000729 D-ribose pyranase; Provisional; Region: PRK11797 426430000730 Sugar transport protein; Region: Sugar_transport; pfam06800 426430000731 Transcriptional regulators [Transcription]; Region: PurR; COG1609 426430000732 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 426430000733 DNA binding site [nucleotide binding] 426430000734 domain linker motif; other site 426430000735 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 426430000736 dimerization interface [polypeptide binding]; other site 426430000737 ligand binding site [chemical binding]; other site 426430000738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 426430000739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430000740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430000741 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 426430000742 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 426430000743 active site 426430000744 Surface antigen [General function prediction only]; Region: COG3942 426430000745 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 426430000746 Peptidase family M23; Region: Peptidase_M23; pfam01551 426430000747 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 426430000748 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 426430000749 Walker A/P-loop; other site 426430000750 ATP binding site [chemical binding]; other site 426430000751 Q-loop/lid; other site 426430000752 ABC transporter signature motif; other site 426430000753 Walker B; other site 426430000754 D-loop; other site 426430000755 H-loop/switch region; other site 426430000756 Surface antigen [General function prediction only]; Region: COG3942 426430000757 CHAP domain; Region: CHAP; pfam05257 426430000758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 426430000759 Predicted membrane protein [Function unknown]; Region: COG1511 426430000760 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 426430000761 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 426430000762 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 426430000763 Predicted membrane protein [Function unknown]; Region: COG4499 426430000764 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 426430000765 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 426430000766 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 426430000767 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 426430000768 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 426430000769 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 426430000770 Uncharacterized conserved protein [Function unknown]; Region: COG5444 426430000771 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 426430000772 Protein of unknown function, DUF600; Region: DUF600; cl04640 426430000773 Protein of unknown function, DUF600; Region: DUF600; cl04640 426430000774 Protein of unknown function, DUF600; Region: DUF600; cl04640 426430000775 Protein of unknown function, DUF600; Region: DUF600; cl04640 426430000776 Protein of unknown function, DUF600; Region: DUF600; cl04640 426430000777 Protein of unknown function, DUF600; Region: DUF600; cl04640 426430000778 Protein of unknown function, DUF600; Region: DUF600; cl04640 426430000779 Protein of unknown function, DUF600; Region: DUF600; cl04640 426430000780 Protein of unknown function, DUF600; Region: DUF600; cl04640 426430000781 Protein of unknown function, DUF600; Region: DUF600; cl04640 426430000782 Protein of unknown function, DUF600; Region: DUF600; cl04640 426430000783 conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741 426430000784 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 426430000785 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 426430000786 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 426430000787 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 426430000788 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 426430000789 FtsX-like permease family; Region: FtsX; pfam02687 426430000790 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 426430000791 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 426430000792 Walker A/P-loop; other site 426430000793 ATP binding site [chemical binding]; other site 426430000794 Q-loop/lid; other site 426430000795 ABC transporter signature motif; other site 426430000796 Walker B; other site 426430000797 D-loop; other site 426430000798 H-loop/switch region; other site 426430000799 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 426430000800 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 426430000801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426430000802 non-specific DNA binding site [nucleotide binding]; other site 426430000803 salt bridge; other site 426430000804 sequence-specific DNA binding site [nucleotide binding]; other site 426430000805 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 426430000806 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 426430000807 substrate binding site [chemical binding]; other site 426430000808 ATP binding site [chemical binding]; other site 426430000809 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 426430000810 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 426430000811 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 426430000812 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 426430000813 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 426430000814 putative transporter; Provisional; Region: PRK10484 426430000815 Na binding site [ion binding]; other site 426430000816 N-acetylneuraminate lyase; Provisional; Region: PRK04147 426430000817 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 426430000818 inhibitor site; inhibition site 426430000819 active site 426430000820 dimer interface [polypeptide binding]; other site 426430000821 catalytic residue [active] 426430000822 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 426430000823 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 426430000824 nucleotide binding site [chemical binding]; other site 426430000825 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 426430000826 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 426430000827 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 426430000828 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 426430000829 putative active site [active] 426430000830 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 426430000831 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 426430000832 putative active site cavity [active] 426430000833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 426430000834 Nucleoside recognition; Region: Gate; pfam07670 426430000835 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 426430000836 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 426430000837 PGAP1-like protein; Region: PGAP1; pfam07819 426430000838 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 426430000839 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 426430000840 Int/Topo IB signature motif; other site 426430000841 Domain of unknown function (DUF955); Region: DUF955; cl01076 426430000842 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426430000843 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426430000844 non-specific DNA binding site [nucleotide binding]; other site 426430000845 salt bridge; other site 426430000846 sequence-specific DNA binding site [nucleotide binding]; other site 426430000847 AntA/AntB antirepressor; Region: AntA; cl01430 426430000848 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 426430000849 Homeodomain-like domain; Region: HTH_23; pfam13384 426430000850 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 426430000851 AAA domain; Region: AAA_24; pfam13479 426430000852 Protein of unknown function (DUF968); Region: DUF968; pfam06147 426430000853 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 426430000854 Helix-turn-helix domain; Region: HTH_36; pfam13730 426430000855 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 426430000856 hypothetical protein; Validated; Region: PRK08116 426430000857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430000858 Walker A motif; other site 426430000859 ATP binding site [chemical binding]; other site 426430000860 Walker B motif; other site 426430000861 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 426430000862 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 426430000863 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 426430000864 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 426430000865 YopX protein; Region: YopX; pfam09643 426430000866 dUTPase; Region: dUTPase_2; pfam08761 426430000867 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 426430000868 active site 426430000869 homodimer interface [polypeptide binding]; other site 426430000870 metal binding site [ion binding]; metal-binding site 426430000871 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 426430000872 Phage terminase large subunit; Region: Terminase_3; cl12054 426430000873 Terminase-like family; Region: Terminase_6; pfam03237 426430000874 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 426430000875 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 426430000876 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 426430000877 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 426430000878 Phage capsid family; Region: Phage_capsid; pfam05065 426430000879 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 426430000880 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 426430000881 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 426430000882 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 426430000883 Pyruvate formate lyase; Region: PFL; pfam02901 426430000884 Phage protein; Region: DUF3647; pfam12363 426430000885 Phage-related protein [Function unknown]; Region: COG5412 426430000886 Phage tail protein; Region: Sipho_tail; pfam05709 426430000887 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 426430000888 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 426430000889 active site 426430000890 catalytic triad [active] 426430000891 oxyanion hole [active] 426430000892 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 426430000893 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 426430000894 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 426430000895 CHAP domain; Region: CHAP; pfam05257 426430000896 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 426430000897 Lysozyme subfamily 2; Region: LYZ2; smart00047 426430000898 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 426430000899 holin, SPP1 family; Region: holin_SPP1; TIGR01592 426430000900 CHAP domain; Region: CHAP; pfam05257 426430000901 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 426430000902 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 426430000903 active site 426430000904 metal binding site [ion binding]; metal-binding site 426430000905 Bacterial SH3 domain; Region: SH3_5; pfam08460 426430000906 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426430000907 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 426430000908 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 426430000909 putative active site [active] 426430000910 putative FMN binding site [chemical binding]; other site 426430000911 putative substrate binding site [chemical binding]; other site 426430000912 putative catalytic residue [active] 426430000913 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 426430000914 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 426430000915 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 426430000916 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 426430000917 lipoyl attachment site [posttranslational modification]; other site 426430000918 Replication protein C N-terminal domain; Region: RP-C; pfam03428 426430000919 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 426430000920 putative ADP-ribose binding site [chemical binding]; other site 426430000921 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 426430000922 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 426430000923 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 426430000924 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 426430000925 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 426430000926 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426430000927 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 426430000928 NADP binding site [chemical binding]; other site 426430000929 putative substrate binding site [chemical binding]; other site 426430000930 active site 426430000931 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 426430000932 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 426430000933 active site 426430000934 P-loop; other site 426430000935 phosphorylation site [posttranslational modification] 426430000936 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 426430000937 active site 426430000938 phosphorylation site [posttranslational modification] 426430000939 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 426430000940 HTH domain; Region: HTH_11; pfam08279 426430000941 HTH domain; Region: HTH_11; pfam08279 426430000942 PRD domain; Region: PRD; pfam00874 426430000943 PRD domain; Region: PRD; pfam00874 426430000944 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 426430000945 active site 426430000946 P-loop; other site 426430000947 phosphorylation site [posttranslational modification] 426430000948 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 426430000949 active site 426430000950 phosphorylation site [posttranslational modification] 426430000951 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426430000952 MarR family; Region: MarR_2; pfam12802 426430000953 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 426430000954 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 426430000955 MepB protein; Region: MepB; cl01985 426430000956 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 426430000957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430000958 putative substrate translocation pore; other site 426430000959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430000960 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 426430000961 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426430000962 Zn binding site [ion binding]; other site 426430000963 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 426430000964 Zn binding site [ion binding]; other site 426430000965 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 426430000966 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 426430000967 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 426430000968 Predicted flavoprotein [General function prediction only]; Region: COG0431 426430000969 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426430000970 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 426430000971 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 426430000972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426430000973 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 426430000974 Imelysin; Region: Peptidase_M75; pfam09375 426430000975 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 426430000976 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 426430000977 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 426430000978 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 426430000979 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 426430000980 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 426430000981 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 426430000982 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 426430000983 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 426430000984 Walker A/P-loop; other site 426430000985 ATP binding site [chemical binding]; other site 426430000986 Q-loop/lid; other site 426430000987 ABC transporter signature motif; other site 426430000988 Walker B; other site 426430000989 D-loop; other site 426430000990 H-loop/switch region; other site 426430000991 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 426430000992 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 426430000993 putative acyltransferase; Provisional; Region: PRK05790 426430000994 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 426430000995 dimer interface [polypeptide binding]; other site 426430000996 active site 426430000997 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 426430000998 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 426430000999 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 426430001000 THF binding site; other site 426430001001 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 426430001002 substrate binding site [chemical binding]; other site 426430001003 THF binding site; other site 426430001004 zinc-binding site [ion binding]; other site 426430001005 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 426430001006 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 426430001007 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 426430001008 FAD binding site [chemical binding]; other site 426430001009 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 426430001010 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 426430001011 homodimer interface [polypeptide binding]; other site 426430001012 substrate-cofactor binding pocket; other site 426430001013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430001014 catalytic residue [active] 426430001015 cystathionine gamma-synthase; Reviewed; Region: PRK08247 426430001016 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426430001017 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426430001018 catalytic residue [active] 426430001019 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 426430001020 ParB-like nuclease domain; Region: ParB; smart00470 426430001021 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 426430001022 Mechanosensitive ion channel; Region: MS_channel; pfam00924 426430001023 GTP-binding protein YchF; Reviewed; Region: PRK09601 426430001024 YchF GTPase; Region: YchF; cd01900 426430001025 G1 box; other site 426430001026 GTP/Mg2+ binding site [chemical binding]; other site 426430001027 Switch I region; other site 426430001028 G2 box; other site 426430001029 Switch II region; other site 426430001030 G3 box; other site 426430001031 G4 box; other site 426430001032 G5 box; other site 426430001033 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 426430001034 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 426430001035 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 426430001036 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 426430001037 dimer interface [polypeptide binding]; other site 426430001038 ssDNA binding site [nucleotide binding]; other site 426430001039 tetramer (dimer of dimers) interface [polypeptide binding]; other site 426430001040 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 426430001041 Abi-like protein; Region: Abi_2; pfam07751 426430001042 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426430001043 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430001044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 426430001045 Predicted membrane protein [Function unknown]; Region: COG3212 426430001046 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 426430001047 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 426430001048 non-specific DNA binding site [nucleotide binding]; other site 426430001049 salt bridge; other site 426430001050 sequence-specific DNA binding site [nucleotide binding]; other site 426430001051 Predicted membrane protein [Function unknown]; Region: COG2261 426430001052 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426430001053 catalytic core [active] 426430001054 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 426430001055 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 426430001056 catalytic residue [active] 426430001057 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 426430001058 catalytic residues [active] 426430001059 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426430001060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426430001061 peroxiredoxin; Region: AhpC; TIGR03137 426430001062 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 426430001063 dimer interface [polypeptide binding]; other site 426430001064 decamer (pentamer of dimers) interface [polypeptide binding]; other site 426430001065 catalytic triad [active] 426430001066 peroxidatic and resolving cysteines [active] 426430001067 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 426430001068 dimer interface [polypeptide binding]; other site 426430001069 FMN binding site [chemical binding]; other site 426430001070 NADPH bind site [chemical binding]; other site 426430001071 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 426430001072 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 426430001073 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426430001074 active site 426430001075 xanthine permease; Region: pbuX; TIGR03173 426430001076 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 426430001077 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 426430001078 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 426430001079 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 426430001080 active site 426430001081 GMP synthase; Reviewed; Region: guaA; PRK00074 426430001082 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 426430001083 AMP/PPi binding site [chemical binding]; other site 426430001084 candidate oxyanion hole; other site 426430001085 catalytic triad [active] 426430001086 potential glutamine specificity residues [chemical binding]; other site 426430001087 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 426430001088 ATP Binding subdomain [chemical binding]; other site 426430001089 Ligand Binding sites [chemical binding]; other site 426430001090 Dimerization subdomain; other site 426430001091 PemK-like protein; Region: PemK; pfam02452 426430001092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 426430001093 Transposase; Region: HTH_Tnp_1; cl17663 426430001094 Predicted membrane protein [Function unknown]; Region: COG3759 426430001095 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 426430001096 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 426430001097 NADP binding site [chemical binding]; other site 426430001098 superantigen-like protein; Reviewed; Region: PRK13037 426430001099 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 426430001100 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430001101 superantigen-like protein; Reviewed; Region: PRK13041 426430001102 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 426430001103 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430001104 superantigen-like protein; Reviewed; Region: PRK13335 426430001105 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 426430001106 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430001107 superantigen-like protein; Reviewed; Region: PRK13042 426430001108 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 426430001109 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430001110 superantigen-like protein 5; Reviewed; Region: PRK13035 426430001111 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 426430001112 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430001113 superantigen-like protein; Reviewed; Region: PRK13040 426430001114 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 426430001115 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430001116 superantigen-like protein 7; Reviewed; Region: PRK13346 426430001117 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 426430001118 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430001119 superantigen-like protein; Reviewed; Region: PRK13039 426430001120 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 426430001121 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430001122 superantigen-like protein; Reviewed; Region: PRK13345 426430001123 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 426430001124 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430001125 superantigen-like protein 5; Reviewed; Region: PRK13035 426430001126 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 426430001127 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430001128 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 426430001129 HsdM N-terminal domain; Region: HsdM_N; pfam12161 426430001130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430001131 S-adenosylmethionine binding site [chemical binding]; other site 426430001132 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 426430001133 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 426430001134 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 426430001135 superantigen-like protein; Reviewed; Region: PRK13036 426430001136 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 426430001137 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430001138 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 426430001139 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430001140 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430001141 Protein of unknown function, DUF576; Region: DUF576; cl04553 426430001142 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430001143 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430001144 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430001145 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430001146 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430001147 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430001148 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430001149 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 426430001150 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 426430001151 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 426430001152 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 426430001153 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 426430001154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 426430001155 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 426430001156 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 426430001157 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 426430001158 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 426430001159 active site 426430001160 Esterase/lipase [General function prediction only]; Region: COG1647 426430001161 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426430001162 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 426430001163 Na2 binding site [ion binding]; other site 426430001164 putative substrate binding site 1 [chemical binding]; other site 426430001165 Na binding site 1 [ion binding]; other site 426430001166 putative substrate binding site 2 [chemical binding]; other site 426430001167 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 426430001168 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 426430001169 dimer interface [polypeptide binding]; other site 426430001170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430001171 catalytic residue [active] 426430001172 cystathionine beta-lyase; Provisional; Region: PRK07671 426430001173 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 426430001174 homodimer interface [polypeptide binding]; other site 426430001175 substrate-cofactor binding pocket; other site 426430001176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430001177 catalytic residue [active] 426430001178 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 426430001179 ABC transporter; Region: ABC_tran; pfam00005 426430001180 Q-loop/lid; other site 426430001181 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 426430001182 ABC transporter signature motif; other site 426430001183 Walker B; other site 426430001184 D-loop; other site 426430001185 H-loop/switch region; other site 426430001186 NIL domain; Region: NIL; pfam09383 426430001187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430001188 dimer interface [polypeptide binding]; other site 426430001189 conserved gate region; other site 426430001190 ABC-ATPase subunit interface; other site 426430001191 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 426430001192 LysM domain; Region: LysM; pfam01476 426430001193 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 426430001194 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 426430001195 Surface antigen [General function prediction only]; Region: COG3942 426430001196 CHAP domain; Region: CHAP; pfam05257 426430001197 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 426430001198 nudix motif; other site 426430001199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430001200 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 426430001201 Coenzyme A binding pocket [chemical binding]; other site 426430001202 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 426430001203 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 426430001204 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426430001205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426430001206 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426430001207 dimerization interface [polypeptide binding]; other site 426430001208 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 426430001209 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 426430001210 active site 426430001211 dimer interface [polypeptide binding]; other site 426430001212 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 426430001213 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 426430001214 active site 426430001215 FMN binding site [chemical binding]; other site 426430001216 substrate binding site [chemical binding]; other site 426430001217 3Fe-4S cluster binding site [ion binding]; other site 426430001218 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 426430001219 domain interface; other site 426430001220 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 426430001221 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 426430001222 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 426430001223 active site turn [active] 426430001224 phosphorylation site [posttranslational modification] 426430001225 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 426430001226 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 426430001227 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 426430001228 Ca binding site [ion binding]; other site 426430001229 active site 426430001230 catalytic site [active] 426430001231 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 426430001232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426430001233 DNA-binding site [nucleotide binding]; DNA binding site 426430001234 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 426430001235 UTRA domain; Region: UTRA; pfam07702 426430001236 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 426430001237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430001238 Coenzyme A binding pocket [chemical binding]; other site 426430001239 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 426430001240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430001241 Walker A motif; other site 426430001242 ATP binding site [chemical binding]; other site 426430001243 Walker B motif; other site 426430001244 arginine finger; other site 426430001245 hypothetical protein; Validated; Region: PRK00153 426430001246 recombination protein RecR; Reviewed; Region: recR; PRK00076 426430001247 RecR protein; Region: RecR; pfam02132 426430001248 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 426430001249 putative active site [active] 426430001250 putative metal-binding site [ion binding]; other site 426430001251 tetramer interface [polypeptide binding]; other site 426430001252 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 426430001253 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426430001254 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426430001255 catalytic residue [active] 426430001256 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 426430001257 thymidylate kinase; Validated; Region: tmk; PRK00698 426430001258 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 426430001259 TMP-binding site; other site 426430001260 ATP-binding site [chemical binding]; other site 426430001261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 426430001262 DNA polymerase III subunit delta'; Validated; Region: PRK08058 426430001263 DNA polymerase III subunit delta'; Validated; Region: PRK08485 426430001264 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 426430001265 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 426430001266 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 426430001267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430001268 S-adenosylmethionine binding site [chemical binding]; other site 426430001269 Predicted methyltransferases [General function prediction only]; Region: COG0313 426430001270 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 426430001271 putative SAM binding site [chemical binding]; other site 426430001272 putative homodimer interface [polypeptide binding]; other site 426430001273 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 426430001274 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 426430001275 active site 426430001276 HIGH motif; other site 426430001277 KMSKS motif; other site 426430001278 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 426430001279 tRNA binding surface [nucleotide binding]; other site 426430001280 anticodon binding site; other site 426430001281 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 426430001282 dimer interface [polypeptide binding]; other site 426430001283 putative tRNA-binding site [nucleotide binding]; other site 426430001284 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 426430001285 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 426430001286 active site 426430001287 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 426430001288 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 426430001289 putative active site [active] 426430001290 putative metal binding site [ion binding]; other site 426430001291 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 426430001292 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 426430001293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430001294 S-adenosylmethionine binding site [chemical binding]; other site 426430001295 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 426430001296 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 426430001297 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 426430001298 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 426430001299 pur operon repressor; Provisional; Region: PRK09213 426430001300 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 426430001301 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426430001302 active site 426430001303 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 426430001304 homotrimer interaction site [polypeptide binding]; other site 426430001305 putative active site [active] 426430001306 regulatory protein SpoVG; Reviewed; Region: PRK13259 426430001307 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 426430001308 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 426430001309 Substrate binding site; other site 426430001310 Mg++ binding site; other site 426430001311 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 426430001312 active site 426430001313 substrate binding site [chemical binding]; other site 426430001314 CoA binding site [chemical binding]; other site 426430001315 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 426430001316 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 426430001317 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426430001318 active site 426430001319 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 426430001320 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 426430001321 5S rRNA interface [nucleotide binding]; other site 426430001322 CTC domain interface [polypeptide binding]; other site 426430001323 L16 interface [polypeptide binding]; other site 426430001324 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 426430001325 putative active site [active] 426430001326 catalytic residue [active] 426430001327 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 426430001328 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 426430001329 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426430001330 ATP binding site [chemical binding]; other site 426430001331 putative Mg++ binding site [ion binding]; other site 426430001332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426430001333 nucleotide binding region [chemical binding]; other site 426430001334 ATP-binding site [chemical binding]; other site 426430001335 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 426430001336 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 426430001337 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 426430001338 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 426430001339 putative SAM binding site [chemical binding]; other site 426430001340 putative homodimer interface [polypeptide binding]; other site 426430001341 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 426430001342 homodimer interface [polypeptide binding]; other site 426430001343 metal binding site [ion binding]; metal-binding site 426430001344 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 426430001345 Septum formation initiator; Region: DivIC; pfam04977 426430001346 hypothetical protein; Provisional; Region: PRK08582 426430001347 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 426430001348 RNA binding site [nucleotide binding]; other site 426430001349 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 426430001350 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 426430001351 Ligand Binding Site [chemical binding]; other site 426430001352 TilS substrate C-terminal domain; Region: TilS_C; smart00977 426430001353 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426430001354 active site 426430001355 FtsH Extracellular; Region: FtsH_ext; pfam06480 426430001356 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 426430001357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430001358 Walker A motif; other site 426430001359 ATP binding site [chemical binding]; other site 426430001360 Walker B motif; other site 426430001361 arginine finger; other site 426430001362 Peptidase family M41; Region: Peptidase_M41; pfam01434 426430001363 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 426430001364 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 426430001365 dimerization interface [polypeptide binding]; other site 426430001366 domain crossover interface; other site 426430001367 redox-dependent activation switch; other site 426430001368 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 426430001369 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 426430001370 dimer interface [polypeptide binding]; other site 426430001371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430001372 catalytic residue [active] 426430001373 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 426430001374 dihydropteroate synthase; Region: DHPS; TIGR01496 426430001375 substrate binding pocket [chemical binding]; other site 426430001376 dimer interface [polypeptide binding]; other site 426430001377 inhibitor binding site; inhibition site 426430001378 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 426430001379 homooctamer interface [polypeptide binding]; other site 426430001380 active site 426430001381 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 426430001382 catalytic center binding site [active] 426430001383 ATP binding site [chemical binding]; other site 426430001384 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 426430001385 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 426430001386 dimer interface [polypeptide binding]; other site 426430001387 putative anticodon binding site; other site 426430001388 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 426430001389 motif 1; other site 426430001390 active site 426430001391 motif 2; other site 426430001392 motif 3; other site 426430001393 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 426430001394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426430001395 DNA-binding site [nucleotide binding]; DNA binding site 426430001396 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426430001397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430001398 homodimer interface [polypeptide binding]; other site 426430001399 catalytic residue [active] 426430001400 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 426430001401 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 426430001402 active site 426430001403 multimer interface [polypeptide binding]; other site 426430001404 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 426430001405 predicted active site [active] 426430001406 catalytic triad [active] 426430001407 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 426430001408 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 426430001409 Nucleoside recognition; Region: Gate; pfam07670 426430001410 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 426430001411 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 426430001412 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 426430001413 UvrB/uvrC motif; Region: UVR; pfam02151 426430001414 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 426430001415 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 426430001416 ADP binding site [chemical binding]; other site 426430001417 phosphagen binding site; other site 426430001418 substrate specificity loop; other site 426430001419 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 426430001420 Clp amino terminal domain; Region: Clp_N; pfam02861 426430001421 Clp amino terminal domain; Region: Clp_N; pfam02861 426430001422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430001423 Walker A motif; other site 426430001424 ATP binding site [chemical binding]; other site 426430001425 Walker B motif; other site 426430001426 arginine finger; other site 426430001427 UvrB/uvrC motif; Region: UVR; pfam02151 426430001428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430001429 Walker A motif; other site 426430001430 ATP binding site [chemical binding]; other site 426430001431 Walker B motif; other site 426430001432 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 426430001433 DNA repair protein RadA; Provisional; Region: PRK11823 426430001434 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 426430001435 Walker A motif/ATP binding site; other site 426430001436 ATP binding site [chemical binding]; other site 426430001437 Walker B motif; other site 426430001438 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 426430001439 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 426430001440 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 426430001441 putative active site [active] 426430001442 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 426430001443 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 426430001444 active site 426430001445 HIGH motif; other site 426430001446 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 426430001447 active site 426430001448 KMSKS motif; other site 426430001449 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 426430001450 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 426430001451 trimer interface [polypeptide binding]; other site 426430001452 active site 426430001453 substrate binding site [chemical binding]; other site 426430001454 CoA binding site [chemical binding]; other site 426430001455 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 426430001456 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 426430001457 active site 426430001458 HIGH motif; other site 426430001459 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 426430001460 KMSKS motif; other site 426430001461 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 426430001462 tRNA binding surface [nucleotide binding]; other site 426430001463 anticodon binding site; other site 426430001464 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 426430001465 active site 426430001466 dimerization interface [polypeptide binding]; other site 426430001467 metal binding site [ion binding]; metal-binding site 426430001468 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 426430001469 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 426430001470 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 426430001471 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 426430001472 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 426430001473 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426430001474 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 426430001475 DNA binding residues [nucleotide binding] 426430001476 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 426430001477 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 426430001478 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 426430001479 putative homodimer interface [polypeptide binding]; other site 426430001480 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 426430001481 heterodimer interface [polypeptide binding]; other site 426430001482 homodimer interface [polypeptide binding]; other site 426430001483 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 426430001484 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 426430001485 23S rRNA interface [nucleotide binding]; other site 426430001486 L7/L12 interface [polypeptide binding]; other site 426430001487 putative thiostrepton binding site; other site 426430001488 L25 interface [polypeptide binding]; other site 426430001489 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 426430001490 mRNA/rRNA interface [nucleotide binding]; other site 426430001491 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 426430001492 23S rRNA interface [nucleotide binding]; other site 426430001493 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 426430001494 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 426430001495 peripheral dimer interface [polypeptide binding]; other site 426430001496 core dimer interface [polypeptide binding]; other site 426430001497 L10 interface [polypeptide binding]; other site 426430001498 L11 interface [polypeptide binding]; other site 426430001499 putative EF-Tu interaction site [polypeptide binding]; other site 426430001500 putative EF-G interaction site [polypeptide binding]; other site 426430001501 Methyltransferase domain; Region: Methyltransf_31; pfam13847 426430001502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430001503 S-adenosylmethionine binding site [chemical binding]; other site 426430001504 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 426430001505 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 426430001506 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 426430001507 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 426430001508 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 426430001509 RPB10 interaction site [polypeptide binding]; other site 426430001510 RPB1 interaction site [polypeptide binding]; other site 426430001511 RPB11 interaction site [polypeptide binding]; other site 426430001512 RPB3 interaction site [polypeptide binding]; other site 426430001513 RPB12 interaction site [polypeptide binding]; other site 426430001514 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 426430001515 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 426430001516 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 426430001517 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 426430001518 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 426430001519 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 426430001520 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 426430001521 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 426430001522 G-loop; other site 426430001523 DNA binding site [nucleotide binding] 426430001524 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 426430001525 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 426430001526 S17 interaction site [polypeptide binding]; other site 426430001527 S8 interaction site; other site 426430001528 16S rRNA interaction site [nucleotide binding]; other site 426430001529 streptomycin interaction site [chemical binding]; other site 426430001530 23S rRNA interaction site [nucleotide binding]; other site 426430001531 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 426430001532 30S ribosomal protein S7; Validated; Region: PRK05302 426430001533 elongation factor G; Reviewed; Region: PRK00007 426430001534 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 426430001535 G1 box; other site 426430001536 putative GEF interaction site [polypeptide binding]; other site 426430001537 GTP/Mg2+ binding site [chemical binding]; other site 426430001538 Switch I region; other site 426430001539 G2 box; other site 426430001540 G3 box; other site 426430001541 Switch II region; other site 426430001542 G4 box; other site 426430001543 G5 box; other site 426430001544 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 426430001545 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 426430001546 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 426430001547 elongation factor Tu; Reviewed; Region: PRK00049 426430001548 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 426430001549 G1 box; other site 426430001550 GEF interaction site [polypeptide binding]; other site 426430001551 GTP/Mg2+ binding site [chemical binding]; other site 426430001552 Switch I region; other site 426430001553 G2 box; other site 426430001554 G3 box; other site 426430001555 Switch II region; other site 426430001556 G4 box; other site 426430001557 G5 box; other site 426430001558 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 426430001559 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 426430001560 Antibiotic Binding Site [chemical binding]; other site 426430001561 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 426430001562 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 426430001563 metal binding site [ion binding]; metal-binding site 426430001564 dimer interface [polypeptide binding]; other site 426430001565 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 426430001566 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 426430001567 substrate-cofactor binding pocket; other site 426430001568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430001569 catalytic residue [active] 426430001570 chaperone protein HchA; Provisional; Region: PRK04155 426430001571 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 426430001572 dimer interface [polypeptide binding]; other site 426430001573 metal binding site [ion binding]; metal-binding site 426430001574 potential oxyanion hole; other site 426430001575 potential catalytic triad [active] 426430001576 conserved cys residue [active] 426430001577 ribulokinase; Provisional; Region: PRK04123 426430001578 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 426430001579 N- and C-terminal domain interface [polypeptide binding]; other site 426430001580 active site 426430001581 MgATP binding site [chemical binding]; other site 426430001582 catalytic site [active] 426430001583 metal binding site [ion binding]; metal-binding site 426430001584 carbohydrate binding site [chemical binding]; other site 426430001585 homodimer interface [polypeptide binding]; other site 426430001586 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426430001587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426430001588 NAD(P) binding site [chemical binding]; other site 426430001589 active site 426430001590 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 426430001591 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 426430001592 homodimer interface [polypeptide binding]; other site 426430001593 substrate-cofactor binding pocket; other site 426430001594 catalytic residue [active] 426430001595 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 426430001596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430001597 motif II; other site 426430001598 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 426430001599 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 426430001600 Substrate-binding site [chemical binding]; other site 426430001601 Substrate specificity [chemical binding]; other site 426430001602 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 426430001603 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 426430001604 Substrate-binding site [chemical binding]; other site 426430001605 Substrate specificity [chemical binding]; other site 426430001606 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 426430001607 nucleoside/Zn binding site; other site 426430001608 dimer interface [polypeptide binding]; other site 426430001609 catalytic motif [active] 426430001610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430001611 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 426430001612 active site 426430001613 motif I; other site 426430001614 motif II; other site 426430001615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430001616 Predicted flavoprotein [General function prediction only]; Region: COG0431 426430001617 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426430001618 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 426430001619 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 426430001620 Cna protein B-type domain; Region: Cna_B; pfam05738 426430001621 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 426430001622 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 426430001623 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 426430001624 Cna protein B-type domain; Region: Cna_B; pfam05738 426430001625 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 426430001626 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 426430001627 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 426430001628 Cna protein B-type domain; Region: Cna_B; pfam05738 426430001629 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 426430001630 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 426430001631 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 426430001632 Cna protein B-type domain; Region: Cna_B; pfam05738 426430001633 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 426430001634 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 426430001635 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 426430001636 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426430001637 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 426430001638 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 426430001639 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426430001640 putative GTP cyclohydrolase; Provisional; Region: PRK13674 426430001641 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 426430001642 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 426430001643 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 426430001644 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 426430001645 active site 426430001646 trimer interface [polypeptide binding]; other site 426430001647 allosteric site; other site 426430001648 active site lid [active] 426430001649 hexamer (dimer of trimers) interface [polypeptide binding]; other site 426430001650 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 426430001651 active site 426430001652 dimer interface [polypeptide binding]; other site 426430001653 magnesium binding site [ion binding]; other site 426430001654 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 426430001655 tetramer interface [polypeptide binding]; other site 426430001656 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 426430001657 active site 426430001658 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 426430001659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430001660 motif II; other site 426430001661 proline/glycine betaine transporter; Provisional; Region: PRK10642 426430001662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430001663 putative substrate translocation pore; other site 426430001664 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 426430001665 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 426430001666 acyl-activating enzyme (AAE) consensus motif; other site 426430001667 AMP binding site [chemical binding]; other site 426430001668 active site 426430001669 CoA binding site [chemical binding]; other site 426430001670 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 426430001671 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 426430001672 dimer interface [polypeptide binding]; other site 426430001673 active site 426430001674 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 426430001675 dimer interface [polypeptide binding]; other site 426430001676 substrate binding site [chemical binding]; other site 426430001677 ATP binding site [chemical binding]; other site 426430001678 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 426430001679 ligand binding site [chemical binding]; other site 426430001680 active site 426430001681 UGI interface [polypeptide binding]; other site 426430001682 catalytic site [active] 426430001683 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 426430001684 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 426430001685 Uncharacterized conserved protein [Function unknown]; Region: COG3610 426430001686 Uncharacterized conserved protein [Function unknown]; Region: COG2966 426430001687 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 426430001688 putative heme peroxidase; Provisional; Region: PRK12276 426430001689 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 426430001690 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 426430001691 mevalonate kinase; Region: mevalon_kin; TIGR00549 426430001692 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 426430001693 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 426430001694 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 426430001695 diphosphomevalonate decarboxylase; Region: PLN02407 426430001696 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 426430001697 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 426430001698 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 426430001699 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 426430001700 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 426430001701 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426430001702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426430001703 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426430001704 Predicted transcriptional regulator [Transcription]; Region: COG1959 426430001705 Transcriptional regulator; Region: Rrf2; pfam02082 426430001706 LXG domain of WXG superfamily; Region: LXG; pfam04740 426430001707 Protein of unknown function (DUF443); Region: DUF443; pfam04276 426430001708 Protein of unknown function (DUF443); Region: DUF443; pfam04276 426430001709 Protein of unknown function (DUF443); Region: DUF443; pfam04276 426430001710 Protein of unknown function (DUF443); Region: DUF443; pfam04276 426430001711 Protein of unknown function (DUF443); Region: DUF443; pfam04276 426430001712 Protein of unknown function (DUF443); Region: DUF443; pfam04276 426430001713 Protein of unknown function (DUF443); Region: DUF443; pfam04276 426430001714 Protein of unknown function (DUF443); Region: DUF443; pfam04276 426430001715 Protein of unknown function (DUF443); Region: DUF443; pfam04276 426430001716 Protein of unknown function (DUF443); Region: DUF443; cl04467 426430001717 Protein of unknown function (DUF443); Region: DUF443; pfam04276 426430001718 Protein of unknown function (DUF443); Region: DUF443; pfam04276 426430001719 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426430001720 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426430001721 active site 426430001722 catalytic tetrad [active] 426430001723 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 426430001724 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426430001725 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 426430001726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430001727 Coenzyme A binding pocket [chemical binding]; other site 426430001728 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 426430001729 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426430001730 Zn2+ binding site [ion binding]; other site 426430001731 Mg2+ binding site [ion binding]; other site 426430001732 YwhD family; Region: YwhD; pfam08741 426430001733 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 426430001734 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 426430001735 NAD binding site [chemical binding]; other site 426430001736 substrate binding site [chemical binding]; other site 426430001737 catalytic Zn binding site [ion binding]; other site 426430001738 tetramer interface [polypeptide binding]; other site 426430001739 structural Zn binding site [ion binding]; other site 426430001740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 426430001741 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 426430001742 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 426430001743 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 426430001744 active site 426430001745 HIGH motif; other site 426430001746 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426430001747 KMSK motif region; other site 426430001748 tRNA binding surface [nucleotide binding]; other site 426430001749 DALR anticodon binding domain; Region: DALR_1; smart00836 426430001750 anticodon binding site; other site 426430001751 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 426430001752 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 426430001753 minor groove reading motif; other site 426430001754 helix-hairpin-helix signature motif; other site 426430001755 substrate binding pocket [chemical binding]; other site 426430001756 active site 426430001757 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 426430001758 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 426430001759 putative binding site residues; other site 426430001760 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426430001761 ABC-ATPase subunit interface; other site 426430001762 dimer interface [polypeptide binding]; other site 426430001763 putative PBP binding regions; other site 426430001764 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 426430001765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430001766 motif II; other site 426430001767 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426430001768 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426430001769 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426430001770 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426430001771 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 426430001772 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426430001773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 426430001774 Protein of unknown function, DUF606; Region: DUF606; pfam04657 426430001775 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 426430001776 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426430001777 active site 426430001778 DNA binding site [nucleotide binding] 426430001779 Int/Topo IB signature motif; other site 426430001780 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 426430001781 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 426430001782 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 426430001783 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 426430001784 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 426430001785 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 426430001786 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 426430001787 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 426430001788 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 426430001789 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 426430001790 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 426430001791 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 426430001792 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 426430001793 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 426430001794 metal binding site [ion binding]; metal-binding site 426430001795 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 426430001796 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426430001797 ABC-ATPase subunit interface; other site 426430001798 dimer interface [polypeptide binding]; other site 426430001799 putative PBP binding regions; other site 426430001800 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 426430001801 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 426430001802 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 426430001803 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 426430001804 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 426430001805 FeoA domain; Region: FeoA; pfam04023 426430001806 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 426430001807 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 426430001808 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 426430001809 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 426430001810 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 426430001811 Walker A/P-loop; other site 426430001812 ATP binding site [chemical binding]; other site 426430001813 Q-loop/lid; other site 426430001814 ABC transporter signature motif; other site 426430001815 Walker B; other site 426430001816 D-loop; other site 426430001817 H-loop/switch region; other site 426430001818 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 426430001819 ABC-2 type transporter; Region: ABC2_membrane; cl17235 426430001820 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 426430001821 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426430001822 active site 426430001823 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426430001824 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 426430001825 active site 426430001826 nucleotide binding site [chemical binding]; other site 426430001827 HIGH motif; other site 426430001828 KMSKS motif; other site 426430001829 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 426430001830 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 426430001831 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 426430001832 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426430001833 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426430001834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426430001835 Walker A/P-loop; other site 426430001836 ATP binding site [chemical binding]; other site 426430001837 Q-loop/lid; other site 426430001838 ABC transporter signature motif; other site 426430001839 Walker B; other site 426430001840 D-loop; other site 426430001841 H-loop/switch region; other site 426430001842 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 426430001843 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 426430001844 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 426430001845 Uncharacterized conserved protein [Function unknown]; Region: COG1284 426430001846 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 426430001847 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 426430001848 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 426430001849 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 426430001850 Walker A/P-loop; other site 426430001851 ATP binding site [chemical binding]; other site 426430001852 Q-loop/lid; other site 426430001853 ABC transporter signature motif; other site 426430001854 Walker B; other site 426430001855 D-loop; other site 426430001856 H-loop/switch region; other site 426430001857 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 426430001858 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426430001859 ABC-ATPase subunit interface; other site 426430001860 dimer interface [polypeptide binding]; other site 426430001861 putative PBP binding regions; other site 426430001862 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 426430001863 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426430001864 ABC-ATPase subunit interface; other site 426430001865 dimer interface [polypeptide binding]; other site 426430001866 putative PBP binding regions; other site 426430001867 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 426430001868 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 426430001869 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 426430001870 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 426430001871 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 426430001872 Uncharacterized membrane protein [Function unknown]; Region: COG3949 426430001873 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 426430001874 Na binding site [ion binding]; other site 426430001875 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 426430001876 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 426430001877 substrate binding pocket [chemical binding]; other site 426430001878 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426430001879 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 426430001880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430001881 Coenzyme A binding pocket [chemical binding]; other site 426430001882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426430001883 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426430001884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426430001885 NAD(P) binding site [chemical binding]; other site 426430001886 active site 426430001887 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426430001888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430001889 active site 426430001890 phosphorylation site [posttranslational modification] 426430001891 intermolecular recognition site; other site 426430001892 dimerization interface [polypeptide binding]; other site 426430001893 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426430001894 DNA binding site [nucleotide binding] 426430001895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426430001896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 426430001897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430001898 ATP binding site [chemical binding]; other site 426430001899 Mg2+ binding site [ion binding]; other site 426430001900 G-X-G motif; other site 426430001901 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 426430001902 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 426430001903 Walker A/P-loop; other site 426430001904 ATP binding site [chemical binding]; other site 426430001905 Q-loop/lid; other site 426430001906 ABC transporter signature motif; other site 426430001907 Walker B; other site 426430001908 D-loop; other site 426430001909 H-loop/switch region; other site 426430001910 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 426430001911 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 426430001912 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 426430001913 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 426430001914 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 426430001915 Surface antigen [General function prediction only]; Region: COG3942 426430001916 CHAP domain; Region: CHAP; pfam05257 426430001917 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 426430001918 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 426430001919 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426430001920 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 426430001921 hypothetical protein; Provisional; Region: PRK12378 426430001922 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 426430001923 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 426430001924 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426430001925 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426430001926 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426430001927 dimerization interface [polypeptide binding]; other site 426430001928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430001929 sugar efflux transporter; Region: 2A0120; TIGR00899 426430001930 putative substrate translocation pore; other site 426430001931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 426430001932 Serine incorporator (Serinc); Region: Serinc; pfam03348 426430001933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430001934 Coenzyme A binding pocket [chemical binding]; other site 426430001935 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 426430001936 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426430001937 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 426430001938 hypothetical protein; Validated; Region: PRK00124 426430001939 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 426430001940 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 426430001941 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 426430001942 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426430001943 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 426430001944 Walker A/P-loop; other site 426430001945 ATP binding site [chemical binding]; other site 426430001946 Q-loop/lid; other site 426430001947 ABC transporter signature motif; other site 426430001948 Walker B; other site 426430001949 D-loop; other site 426430001950 H-loop/switch region; other site 426430001951 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 426430001952 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426430001953 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 426430001954 Walker A/P-loop; other site 426430001955 ATP binding site [chemical binding]; other site 426430001956 Q-loop/lid; other site 426430001957 ABC transporter signature motif; other site 426430001958 Walker B; other site 426430001959 D-loop; other site 426430001960 H-loop/switch region; other site 426430001961 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426430001962 MarR family; Region: MarR; pfam01047 426430001963 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 426430001964 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 426430001965 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 426430001966 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426430001967 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426430001968 active site 426430001969 catalytic tetrad [active] 426430001970 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 426430001971 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 426430001972 transmembrane helices; other site 426430001973 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 426430001974 DNA photolyase; Region: DNA_photolyase; pfam00875 426430001975 Predicted membrane protein [Function unknown]; Region: COG4330 426430001976 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 426430001977 trimer interface [polypeptide binding]; other site 426430001978 putative Zn binding site [ion binding]; other site 426430001979 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 426430001980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430001981 putative substrate translocation pore; other site 426430001982 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 426430001983 putative deacylase active site [active] 426430001984 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 426430001985 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 426430001986 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 426430001987 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 426430001988 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 426430001989 putative substrate binding site [chemical binding]; other site 426430001990 putative ATP binding site [chemical binding]; other site 426430001991 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 426430001992 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 426430001993 active site 426430001994 phosphorylation site [posttranslational modification] 426430001995 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 426430001996 active site 426430001997 P-loop; other site 426430001998 phosphorylation site [posttranslational modification] 426430001999 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 426430002000 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 426430002001 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 426430002002 active site 426430002003 dimer interface [polypeptide binding]; other site 426430002004 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 426430002005 Domain of unknown function DUF21; Region: DUF21; pfam01595 426430002006 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 426430002007 Transporter associated domain; Region: CorC_HlyC; pfam03471 426430002008 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426430002009 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426430002010 active site 426430002011 catalytic tetrad [active] 426430002012 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 426430002013 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 426430002014 Ligand binding site; other site 426430002015 Putative Catalytic site; other site 426430002016 DXD motif; other site 426430002017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426430002018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426430002019 dimer interface [polypeptide binding]; other site 426430002020 phosphorylation site [posttranslational modification] 426430002021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430002022 ATP binding site [chemical binding]; other site 426430002023 Mg2+ binding site [ion binding]; other site 426430002024 G-X-G motif; other site 426430002025 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426430002026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430002027 active site 426430002028 phosphorylation site [posttranslational modification] 426430002029 intermolecular recognition site; other site 426430002030 dimerization interface [polypeptide binding]; other site 426430002031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426430002032 DNA binding site [nucleotide binding] 426430002033 DoxX; Region: DoxX; pfam07681 426430002034 Electron transfer DM13; Region: DM13; pfam10517 426430002035 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 426430002036 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 426430002037 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 426430002038 active site 426430002039 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 426430002040 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 426430002041 Ligand Binding Site [chemical binding]; other site 426430002042 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 426430002043 Glutamine amidotransferase class-I; Region: GATase; pfam00117 426430002044 glutamine binding [chemical binding]; other site 426430002045 catalytic triad [active] 426430002046 aminodeoxychorismate synthase; Provisional; Region: PRK07508 426430002047 chorismate binding enzyme; Region: Chorismate_bind; cl10555 426430002048 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 426430002049 substrate-cofactor binding pocket; other site 426430002050 Aminotransferase class IV; Region: Aminotran_4; pfam01063 426430002051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430002052 catalytic residue [active] 426430002053 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 426430002054 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 426430002055 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 426430002056 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 426430002057 Sulfatase; Region: Sulfatase; pfam00884 426430002058 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 426430002059 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426430002060 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426430002061 ABC transporter; Region: ABC_tran_2; pfam12848 426430002062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426430002063 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 426430002064 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426430002065 ATP binding site [chemical binding]; other site 426430002066 putative Mg++ binding site [ion binding]; other site 426430002067 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426430002068 nucleotide binding region [chemical binding]; other site 426430002069 ATP-binding site [chemical binding]; other site 426430002070 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 426430002071 HRDC domain; Region: HRDC; pfam00570 426430002072 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 426430002073 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 426430002074 Walker A/P-loop; other site 426430002075 ATP binding site [chemical binding]; other site 426430002076 Q-loop/lid; other site 426430002077 ABC transporter signature motif; other site 426430002078 Walker B; other site 426430002079 D-loop; other site 426430002080 H-loop/switch region; other site 426430002081 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426430002082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430002083 dimer interface [polypeptide binding]; other site 426430002084 conserved gate region; other site 426430002085 ABC-ATPase subunit interface; other site 426430002086 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 426430002087 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 426430002088 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 426430002089 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426430002090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430002091 homodimer interface [polypeptide binding]; other site 426430002092 catalytic residue [active] 426430002093 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 426430002094 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 426430002095 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 426430002096 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 426430002097 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 426430002098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430002099 putative substrate translocation pore; other site 426430002100 POT family; Region: PTR2; cl17359 426430002101 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 426430002102 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 426430002103 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 426430002104 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 426430002105 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 426430002106 Class I ribonucleotide reductase; Region: RNR_I; cd01679 426430002107 active site 426430002108 dimer interface [polypeptide binding]; other site 426430002109 catalytic residues [active] 426430002110 effector binding site; other site 426430002111 R2 peptide binding site; other site 426430002112 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 426430002113 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 426430002114 dimer interface [polypeptide binding]; other site 426430002115 putative radical transfer pathway; other site 426430002116 diiron center [ion binding]; other site 426430002117 tyrosyl radical; other site 426430002118 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426430002119 ABC-ATPase subunit interface; other site 426430002120 dimer interface [polypeptide binding]; other site 426430002121 putative PBP binding regions; other site 426430002122 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426430002123 ABC-ATPase subunit interface; other site 426430002124 dimer interface [polypeptide binding]; other site 426430002125 putative PBP binding regions; other site 426430002126 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 426430002127 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 426430002128 Walker A/P-loop; other site 426430002129 ATP binding site [chemical binding]; other site 426430002130 Q-loop/lid; other site 426430002131 ABC transporter signature motif; other site 426430002132 Walker B; other site 426430002133 D-loop; other site 426430002134 H-loop/switch region; other site 426430002135 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 426430002136 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 426430002137 putative ligand binding residues [chemical binding]; other site 426430002138 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 426430002139 CHY zinc finger; Region: zf-CHY; pfam05495 426430002140 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 426430002141 FAD binding domain; Region: FAD_binding_4; pfam01565 426430002142 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 426430002143 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 426430002144 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 426430002145 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 426430002146 peptidase T; Region: peptidase-T; TIGR01882 426430002147 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 426430002148 metal binding site [ion binding]; metal-binding site 426430002149 dimer interface [polypeptide binding]; other site 426430002150 Uncharacterized conserved protein [Function unknown]; Region: COG3610 426430002151 Uncharacterized conserved protein [Function unknown]; Region: COG2966 426430002152 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 426430002153 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 426430002154 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 426430002155 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426430002156 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426430002157 metal binding site [ion binding]; metal-binding site 426430002158 active site 426430002159 I-site; other site 426430002160 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 426430002161 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 426430002162 Mg++ binding site [ion binding]; other site 426430002163 putative catalytic motif [active] 426430002164 substrate binding site [chemical binding]; other site 426430002165 Uncharacterized conserved protein [Function unknown]; Region: COG1739 426430002166 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 426430002167 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 426430002168 EDD domain protein, DegV family; Region: DegV; TIGR00762 426430002169 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 426430002170 DEAD-like helicases superfamily; Region: DEXDc; smart00487 426430002171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426430002172 ATP binding site [chemical binding]; other site 426430002173 putative Mg++ binding site [ion binding]; other site 426430002174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426430002175 nucleotide binding region [chemical binding]; other site 426430002176 ATP-binding site [chemical binding]; other site 426430002177 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 426430002178 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426430002179 active site 426430002180 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 426430002181 30S subunit binding site; other site 426430002182 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 426430002183 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 426430002184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 426430002185 nucleotide binding region [chemical binding]; other site 426430002186 ATP-binding site [chemical binding]; other site 426430002187 SEC-C motif; Region: SEC-C; pfam02810 426430002188 peptide chain release factor 2; Provisional; Region: PRK06746 426430002189 This domain is found in peptide chain release factors; Region: PCRF; smart00937 426430002190 RF-1 domain; Region: RF-1; pfam00472 426430002191 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 426430002192 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 426430002193 Surface antigen [General function prediction only]; Region: COG3942 426430002194 CHAP domain; Region: CHAP; pfam05257 426430002195 HD domain; Region: HD_3; cl17350 426430002196 excinuclease ABC subunit B; Provisional; Region: PRK05298 426430002197 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426430002198 ATP binding site [chemical binding]; other site 426430002199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426430002200 nucleotide binding region [chemical binding]; other site 426430002201 ATP-binding site [chemical binding]; other site 426430002202 Ultra-violet resistance protein B; Region: UvrB; pfam12344 426430002203 UvrB/uvrC motif; Region: UVR; pfam02151 426430002204 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 426430002205 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 426430002206 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 426430002207 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 426430002208 HPr kinase/phosphorylase; Provisional; Region: PRK05428 426430002209 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 426430002210 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 426430002211 Hpr binding site; other site 426430002212 active site 426430002213 homohexamer subunit interaction site [polypeptide binding]; other site 426430002214 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 426430002215 putative acyl transferase; Provisional; Region: PRK10191 426430002216 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 426430002217 trimer interface [polypeptide binding]; other site 426430002218 active site 426430002219 substrate binding site [chemical binding]; other site 426430002220 CoA binding site [chemical binding]; other site 426430002221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 426430002222 binding surface 426430002223 TPR motif; other site 426430002224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426430002225 TPR motif; other site 426430002226 binding surface 426430002227 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 426430002228 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426430002229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426430002230 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 426430002231 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 426430002232 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 426430002233 phosphate binding site [ion binding]; other site 426430002234 dimer interface [polypeptide binding]; other site 426430002235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 426430002236 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 426430002237 Clp protease; Region: CLP_protease; pfam00574 426430002238 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 426430002239 oligomer interface [polypeptide binding]; other site 426430002240 active site residues [active] 426430002241 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 426430002242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426430002243 NAD(P) binding site [chemical binding]; other site 426430002244 active site 426430002245 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 426430002246 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 426430002247 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 426430002248 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 426430002249 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 426430002250 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 426430002251 Phosphoglycerate kinase; Region: PGK; pfam00162 426430002252 substrate binding site [chemical binding]; other site 426430002253 hinge regions; other site 426430002254 ADP binding site [chemical binding]; other site 426430002255 catalytic site [active] 426430002256 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 426430002257 triosephosphate isomerase; Provisional; Region: PRK14565 426430002258 substrate binding site [chemical binding]; other site 426430002259 dimer interface [polypeptide binding]; other site 426430002260 catalytic triad [active] 426430002261 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 426430002262 phosphoglyceromutase; Provisional; Region: PRK05434 426430002263 enolase; Provisional; Region: eno; PRK00077 426430002264 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 426430002265 dimer interface [polypeptide binding]; other site 426430002266 metal binding site [ion binding]; metal-binding site 426430002267 substrate binding pocket [chemical binding]; other site 426430002268 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 426430002269 Esterase/lipase [General function prediction only]; Region: COG1647 426430002270 Baculovirus DNA helicase; Region: Baculo_helicase; pfam04735 426430002271 ribonuclease R; Region: RNase_R; TIGR02063 426430002272 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 426430002273 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 426430002274 RNB domain; Region: RNB; pfam00773 426430002275 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 426430002276 RNA binding site [nucleotide binding]; other site 426430002277 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 426430002278 SmpB-tmRNA interface; other site 426430002279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430002280 Coenzyme A binding pocket [chemical binding]; other site 426430002281 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 426430002282 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 426430002283 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 426430002284 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 426430002285 Staphylococcal nuclease homologues; Region: SNc; smart00318 426430002286 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 426430002287 Catalytic site; other site 426430002288 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426430002289 DNA-binding site [nucleotide binding]; DNA binding site 426430002290 RNA-binding motif; other site 426430002291 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 426430002292 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 426430002293 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426430002294 catalytic core [active] 426430002295 Lysine efflux permease [General function prediction only]; Region: COG1279 426430002296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426430002297 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 426430002298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426430002299 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 426430002300 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 426430002301 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 426430002302 active site 426430002303 catalytic residue [active] 426430002304 dimer interface [polypeptide binding]; other site 426430002305 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 426430002306 putative FMN binding site [chemical binding]; other site 426430002307 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 426430002308 catalytic residues [active] 426430002309 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 426430002310 ArsC family; Region: ArsC; pfam03960 426430002311 putative ArsC-like catalytic residues; other site 426430002312 putative TRX-like catalytic residues [active] 426430002313 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 426430002314 lipoyl attachment site [posttranslational modification]; other site 426430002315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 426430002316 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 426430002317 putative active site [active] 426430002318 putative metal binding site [ion binding]; other site 426430002319 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 426430002320 catalytic residues [active] 426430002321 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 426430002322 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 426430002323 Walker A/P-loop; other site 426430002324 ATP binding site [chemical binding]; other site 426430002325 Q-loop/lid; other site 426430002326 ABC transporter signature motif; other site 426430002327 Walker B; other site 426430002328 D-loop; other site 426430002329 H-loop/switch region; other site 426430002330 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 426430002331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430002332 dimer interface [polypeptide binding]; other site 426430002333 conserved gate region; other site 426430002334 ABC-ATPase subunit interface; other site 426430002335 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 426430002336 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 426430002337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 426430002338 Predicted membrane protein [Function unknown]; Region: COG2035 426430002339 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 426430002340 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 426430002341 Walker A/P-loop; other site 426430002342 ATP binding site [chemical binding]; other site 426430002343 Q-loop/lid; other site 426430002344 ABC transporter signature motif; other site 426430002345 Walker B; other site 426430002346 D-loop; other site 426430002347 H-loop/switch region; other site 426430002348 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 426430002349 FeS assembly protein SufD; Region: sufD; TIGR01981 426430002350 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 426430002351 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 426430002352 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426430002353 catalytic residue [active] 426430002354 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 426430002355 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 426430002356 trimerization site [polypeptide binding]; other site 426430002357 active site 426430002358 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 426430002359 FeS assembly protein SufB; Region: sufB; TIGR01980 426430002360 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 426430002361 Domain of unknown function DUF21; Region: DUF21; pfam01595 426430002362 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 426430002363 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 426430002364 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 426430002365 FMN binding site [chemical binding]; other site 426430002366 substrate binding site [chemical binding]; other site 426430002367 putative catalytic residue [active] 426430002368 Uncharacterized conserved protein [Function unknown]; Region: COG1801 426430002369 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 426430002370 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 426430002371 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 426430002372 active site 426430002373 metal binding site [ion binding]; metal-binding site 426430002374 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 426430002375 lipoyl synthase; Provisional; Region: PRK05481 426430002376 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426430002377 FeS/SAM binding site; other site 426430002378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 426430002379 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 426430002380 Uncharacterized conserved protein [Function unknown]; Region: COG2445 426430002381 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 426430002382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430002383 active site 426430002384 motif I; other site 426430002385 motif II; other site 426430002386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430002387 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 426430002388 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 426430002389 dimerization interface [polypeptide binding]; other site 426430002390 ligand binding site [chemical binding]; other site 426430002391 NADP binding site [chemical binding]; other site 426430002392 catalytic site [active] 426430002393 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 426430002394 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 426430002395 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 426430002396 acyl-activating enzyme (AAE) consensus motif; other site 426430002397 AMP binding site [chemical binding]; other site 426430002398 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 426430002399 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 426430002400 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 426430002401 DltD N-terminal region; Region: DltD_N; pfam04915 426430002402 DltD central region; Region: DltD_M; pfam04918 426430002403 DltD C-terminal region; Region: DltD_C; pfam04914 426430002404 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 426430002405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 426430002406 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 426430002407 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426430002408 hypothetical protein; Provisional; Region: PRK13669 426430002409 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 426430002410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426430002411 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 426430002412 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 426430002413 interface (dimer of trimers) [polypeptide binding]; other site 426430002414 Substrate-binding/catalytic site; other site 426430002415 Zn-binding sites [ion binding]; other site 426430002416 Predicted permease [General function prediction only]; Region: COG2056 426430002417 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 426430002418 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 426430002419 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 426430002420 CoenzymeA binding site [chemical binding]; other site 426430002421 subunit interaction site [polypeptide binding]; other site 426430002422 PHB binding site; other site 426430002423 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426430002424 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 426430002425 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 426430002426 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 426430002427 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 426430002428 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 426430002429 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 426430002430 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 426430002431 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 426430002432 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 426430002433 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 426430002434 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 426430002435 Kinase associated protein B; Region: KapB; pfam08810 426430002436 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 426430002437 active site 426430002438 general stress protein 13; Validated; Region: PRK08059 426430002439 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 426430002440 RNA binding site [nucleotide binding]; other site 426430002441 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 426430002442 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 426430002443 putative active site [active] 426430002444 putative FMN binding site [chemical binding]; other site 426430002445 putative substrate binding site [chemical binding]; other site 426430002446 putative catalytic residue [active] 426430002447 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 426430002448 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426430002449 inhibitor-cofactor binding pocket; inhibition site 426430002450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430002451 catalytic residue [active] 426430002452 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 426430002453 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 426430002454 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 426430002455 NAD(P) binding site [chemical binding]; other site 426430002456 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 426430002457 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 426430002458 active site 426430002459 catalytic site [active] 426430002460 metal binding site [ion binding]; metal-binding site 426430002461 argininosuccinate lyase; Provisional; Region: PRK00855 426430002462 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 426430002463 active sites [active] 426430002464 tetramer interface [polypeptide binding]; other site 426430002465 argininosuccinate synthase; Provisional; Region: PRK13820 426430002466 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 426430002467 ANP binding site [chemical binding]; other site 426430002468 Substrate Binding Site II [chemical binding]; other site 426430002469 Substrate Binding Site I [chemical binding]; other site 426430002470 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 426430002471 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 426430002472 active site 426430002473 dimer interface [polypeptide binding]; other site 426430002474 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 426430002475 dimer interface [polypeptide binding]; other site 426430002476 active site 426430002477 Uncharacterized conserved protein [Function unknown]; Region: COG0398 426430002478 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 426430002479 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 426430002480 Catalytic site [active] 426430002481 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 426430002482 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 426430002483 Catalytic site [active] 426430002484 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 426430002485 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 426430002486 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 426430002487 Part of AAA domain; Region: AAA_19; pfam13245 426430002488 Family description; Region: UvrD_C_2; pfam13538 426430002489 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 426430002490 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 426430002491 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426430002492 hypothetical protein; Provisional; Region: PRK13673 426430002493 coenzyme A disulfide reductase; Provisional; Region: PRK13512 426430002494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426430002495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426430002496 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426430002497 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 426430002498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430002499 active site 426430002500 motif I; other site 426430002501 motif II; other site 426430002502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430002503 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 426430002504 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426430002505 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 426430002506 catalytic triad [active] 426430002507 catalytic triad [active] 426430002508 oxyanion hole [active] 426430002509 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 426430002510 Clp amino terminal domain; Region: Clp_N; pfam02861 426430002511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430002512 Walker A motif; other site 426430002513 ATP binding site [chemical binding]; other site 426430002514 Walker B motif; other site 426430002515 arginine finger; other site 426430002516 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 426430002517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430002518 Walker A motif; other site 426430002519 ATP binding site [chemical binding]; other site 426430002520 Walker B motif; other site 426430002521 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 426430002522 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426430002523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426430002524 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426430002525 dimerization interface [polypeptide binding]; other site 426430002526 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 426430002527 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 426430002528 active site 426430002529 catalytic residues [active] 426430002530 metal binding site [ion binding]; metal-binding site 426430002531 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 426430002532 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 426430002533 substrate binding site [chemical binding]; other site 426430002534 MAP domain; Region: MAP; pfam03642 426430002535 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 426430002536 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 426430002537 dimer interface [polypeptide binding]; other site 426430002538 active site 426430002539 CoA binding pocket [chemical binding]; other site 426430002540 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 426430002541 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 426430002542 dimer interface [polypeptide binding]; other site 426430002543 active site 426430002544 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 426430002545 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426430002546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430002547 dimer interface [polypeptide binding]; other site 426430002548 conserved gate region; other site 426430002549 putative PBP binding loops; other site 426430002550 ABC-ATPase subunit interface; other site 426430002551 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426430002552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430002553 dimer interface [polypeptide binding]; other site 426430002554 conserved gate region; other site 426430002555 putative PBP binding loops; other site 426430002556 ABC-ATPase subunit interface; other site 426430002557 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 426430002558 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426430002559 Walker A/P-loop; other site 426430002560 ATP binding site [chemical binding]; other site 426430002561 Q-loop/lid; other site 426430002562 ABC transporter signature motif; other site 426430002563 Walker B; other site 426430002564 D-loop; other site 426430002565 H-loop/switch region; other site 426430002566 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426430002567 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 426430002568 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426430002569 Walker A/P-loop; other site 426430002570 ATP binding site [chemical binding]; other site 426430002571 Q-loop/lid; other site 426430002572 ABC transporter signature motif; other site 426430002573 Walker B; other site 426430002574 D-loop; other site 426430002575 H-loop/switch region; other site 426430002576 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426430002577 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 426430002578 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 426430002579 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 426430002580 peptide binding site [polypeptide binding]; other site 426430002581 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426430002582 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 426430002583 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 426430002584 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426430002585 Walker A/P-loop; other site 426430002586 ATP binding site [chemical binding]; other site 426430002587 Q-loop/lid; other site 426430002588 ABC transporter signature motif; other site 426430002589 Walker B; other site 426430002590 D-loop; other site 426430002591 H-loop/switch region; other site 426430002592 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426430002593 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 426430002594 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426430002595 Walker A/P-loop; other site 426430002596 ATP binding site [chemical binding]; other site 426430002597 Q-loop/lid; other site 426430002598 ABC transporter signature motif; other site 426430002599 Walker B; other site 426430002600 D-loop; other site 426430002601 H-loop/switch region; other site 426430002602 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 426430002603 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426430002604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430002605 dimer interface [polypeptide binding]; other site 426430002606 conserved gate region; other site 426430002607 putative PBP binding loops; other site 426430002608 ABC-ATPase subunit interface; other site 426430002609 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 426430002610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430002611 dimer interface [polypeptide binding]; other site 426430002612 conserved gate region; other site 426430002613 putative PBP binding loops; other site 426430002614 ABC-ATPase subunit interface; other site 426430002615 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 426430002616 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 426430002617 active site 426430002618 HIGH motif; other site 426430002619 dimer interface [polypeptide binding]; other site 426430002620 KMSKS motif; other site 426430002621 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 426430002622 ArsC family; Region: ArsC; pfam03960 426430002623 putative catalytic residues [active] 426430002624 thiol/disulfide switch; other site 426430002625 adaptor protein; Provisional; Region: PRK02315 426430002626 Competence protein CoiA-like family; Region: CoiA; cl11541 426430002627 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 426430002628 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 426430002629 active site 426430002630 Zn binding site [ion binding]; other site 426430002631 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 426430002632 Thioredoxin; Region: Thioredoxin_5; pfam13743 426430002633 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 426430002634 apolar tunnel; other site 426430002635 heme binding site [chemical binding]; other site 426430002636 dimerization interface [polypeptide binding]; other site 426430002637 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 426430002638 putative active site [active] 426430002639 putative metal binding residues [ion binding]; other site 426430002640 signature motif; other site 426430002641 putative triphosphate binding site [ion binding]; other site 426430002642 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 426430002643 synthetase active site [active] 426430002644 NTP binding site [chemical binding]; other site 426430002645 metal binding site [ion binding]; metal-binding site 426430002646 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 426430002647 ATP-NAD kinase; Region: NAD_kinase; pfam01513 426430002648 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 426430002649 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 426430002650 active site 426430002651 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 426430002652 MgtE intracellular N domain; Region: MgtE_N; smart00924 426430002653 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 426430002654 Divalent cation transporter; Region: MgtE; pfam01769 426430002655 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 426430002656 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 426430002657 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 426430002658 TrkA-N domain; Region: TrkA_N; pfam02254 426430002659 TrkA-C domain; Region: TrkA_C; pfam02080 426430002660 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 426430002661 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 426430002662 NAD binding site [chemical binding]; other site 426430002663 homotetramer interface [polypeptide binding]; other site 426430002664 homodimer interface [polypeptide binding]; other site 426430002665 substrate binding site [chemical binding]; other site 426430002666 active site 426430002667 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 426430002668 Domain of unknown function DUF20; Region: UPF0118; pfam01594 426430002669 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 426430002670 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 426430002671 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 426430002672 Putative esterase; Region: Esterase; pfam00756 426430002673 hypothetical protein; Provisional; Region: PRK13679 426430002674 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 426430002675 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426430002676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430002677 putative substrate translocation pore; other site 426430002678 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 426430002679 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 426430002680 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426430002681 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 426430002682 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 426430002683 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426430002684 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 426430002685 YueH-like protein; Region: YueH; pfam14166 426430002686 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 426430002687 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 426430002688 G1 box; other site 426430002689 putative GEF interaction site [polypeptide binding]; other site 426430002690 GTP/Mg2+ binding site [chemical binding]; other site 426430002691 Switch I region; other site 426430002692 G2 box; other site 426430002693 G3 box; other site 426430002694 Switch II region; other site 426430002695 G4 box; other site 426430002696 G5 box; other site 426430002697 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 426430002698 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 426430002699 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 426430002700 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426430002701 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426430002702 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 426430002703 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 426430002704 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 426430002705 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426430002706 active site 426430002707 metal binding site [ion binding]; metal-binding site 426430002708 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 426430002709 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 426430002710 IDEAL domain; Region: IDEAL; pfam08858 426430002711 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 426430002712 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 426430002713 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 426430002714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 426430002715 CAAX protease self-immunity; Region: Abi; pfam02517 426430002716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 426430002717 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 426430002718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 426430002719 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 426430002720 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 426430002721 Walker A/P-loop; other site 426430002722 ATP binding site [chemical binding]; other site 426430002723 Q-loop/lid; other site 426430002724 ABC transporter signature motif; other site 426430002725 Walker B; other site 426430002726 D-loop; other site 426430002727 H-loop/switch region; other site 426430002728 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 426430002729 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 426430002730 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426430002731 Predicted membrane protein [Function unknown]; Region: COG2259 426430002732 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 426430002733 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 426430002734 siderophore binding site; other site 426430002735 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 426430002736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430002737 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 426430002738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426430002739 Coenzyme A binding pocket [chemical binding]; other site 426430002740 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 426430002741 UbiA prenyltransferase family; Region: UbiA; pfam01040 426430002742 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 426430002743 isochorismate synthases; Region: isochor_syn; TIGR00543 426430002744 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 426430002745 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 426430002746 dimer interface [polypeptide binding]; other site 426430002747 tetramer interface [polypeptide binding]; other site 426430002748 PYR/PP interface [polypeptide binding]; other site 426430002749 TPP binding site [chemical binding]; other site 426430002750 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 426430002751 TPP-binding site; other site 426430002752 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 426430002753 PGAP1-like protein; Region: PGAP1; pfam07819 426430002754 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426430002755 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 426430002756 substrate binding site [chemical binding]; other site 426430002757 oxyanion hole (OAH) forming residues; other site 426430002758 trimer interface [polypeptide binding]; other site 426430002759 Staphostatin B; Region: Staphostatin_B; pfam09023 426430002760 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 426430002761 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 426430002762 aminotransferase A; Validated; Region: PRK07683 426430002763 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426430002764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430002765 homodimer interface [polypeptide binding]; other site 426430002766 catalytic residue [active] 426430002767 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 426430002768 Acyltransferase family; Region: Acyl_transf_3; pfam01757 426430002769 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426430002770 MarR family; Region: MarR; pfam01047 426430002771 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 426430002772 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 426430002773 amidase catalytic site [active] 426430002774 Zn binding residues [ion binding]; other site 426430002775 substrate binding site [chemical binding]; other site 426430002776 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 426430002777 Lysozyme subfamily 2; Region: LYZ2; smart00047 426430002778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430002779 Coenzyme A binding pocket [chemical binding]; other site 426430002780 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 426430002781 Transcriptional regulator [Transcription]; Region: LytR; COG1316 426430002782 Beta-lactamase; Region: Beta-lactamase; pfam00144 426430002783 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 426430002784 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 426430002785 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 426430002786 Subunit I/III interface [polypeptide binding]; other site 426430002787 Subunit III/IV interface [polypeptide binding]; other site 426430002788 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 426430002789 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 426430002790 D-pathway; other site 426430002791 Putative ubiquinol binding site [chemical binding]; other site 426430002792 Low-spin heme (heme b) binding site [chemical binding]; other site 426430002793 Putative water exit pathway; other site 426430002794 Binuclear center (heme o3/CuB) [ion binding]; other site 426430002795 K-pathway; other site 426430002796 Putative proton exit pathway; other site 426430002797 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 426430002798 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 426430002799 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 426430002800 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 426430002801 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 426430002802 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 426430002803 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 426430002804 homodimer interface [polypeptide binding]; other site 426430002805 NADP binding site [chemical binding]; other site 426430002806 substrate binding site [chemical binding]; other site 426430002807 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 426430002808 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 426430002809 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 426430002810 NAD binding site [chemical binding]; other site 426430002811 ATP-grasp domain; Region: ATP-grasp; pfam02222 426430002812 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 426430002813 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 426430002814 ATP binding site [chemical binding]; other site 426430002815 active site 426430002816 substrate binding site [chemical binding]; other site 426430002817 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 426430002818 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 426430002819 putative active site [active] 426430002820 catalytic triad [active] 426430002821 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 426430002822 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 426430002823 dimerization interface [polypeptide binding]; other site 426430002824 ATP binding site [chemical binding]; other site 426430002825 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 426430002826 dimerization interface [polypeptide binding]; other site 426430002827 ATP binding site [chemical binding]; other site 426430002828 amidophosphoribosyltransferase; Provisional; Region: PRK07272 426430002829 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 426430002830 active site 426430002831 tetramer interface [polypeptide binding]; other site 426430002832 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426430002833 active site 426430002834 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 426430002835 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 426430002836 dimerization interface [polypeptide binding]; other site 426430002837 putative ATP binding site [chemical binding]; other site 426430002838 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 426430002839 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 426430002840 active site 426430002841 substrate binding site [chemical binding]; other site 426430002842 cosubstrate binding site; other site 426430002843 catalytic site [active] 426430002844 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 426430002845 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 426430002846 purine monophosphate binding site [chemical binding]; other site 426430002847 dimer interface [polypeptide binding]; other site 426430002848 putative catalytic residues [active] 426430002849 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 426430002850 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 426430002851 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 426430002852 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 426430002853 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 426430002854 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 426430002855 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 426430002856 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 426430002857 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 426430002858 Walker A/P-loop; other site 426430002859 ATP binding site [chemical binding]; other site 426430002860 Q-loop/lid; other site 426430002861 ABC transporter signature motif; other site 426430002862 Walker B; other site 426430002863 D-loop; other site 426430002864 H-loop/switch region; other site 426430002865 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 426430002866 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 426430002867 Walker A/P-loop; other site 426430002868 ATP binding site [chemical binding]; other site 426430002869 Q-loop/lid; other site 426430002870 ABC transporter signature motif; other site 426430002871 Walker B; other site 426430002872 D-loop; other site 426430002873 H-loop/switch region; other site 426430002874 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 426430002875 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 426430002876 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 426430002877 putative RNA binding site [nucleotide binding]; other site 426430002878 Methyltransferase domain; Region: Methyltransf_26; pfam13659 426430002879 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 426430002880 dimerization domain swap beta strand [polypeptide binding]; other site 426430002881 regulatory protein interface [polypeptide binding]; other site 426430002882 active site 426430002883 regulatory phosphorylation site [posttranslational modification]; other site 426430002884 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 426430002885 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 426430002886 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 426430002887 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 426430002888 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 426430002889 catalytic residues [active] 426430002890 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 426430002891 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 426430002892 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 426430002893 TrkA-N domain; Region: TrkA_N; pfam02254 426430002894 TrkA-C domain; Region: TrkA_C; pfam02080 426430002895 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 426430002896 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 426430002897 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 426430002898 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 426430002899 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 426430002900 active site 426430002901 catalytic residues [active] 426430002902 metal binding site [ion binding]; metal-binding site 426430002903 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 426430002904 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 426430002905 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 426430002906 TPP-binding site [chemical binding]; other site 426430002907 tetramer interface [polypeptide binding]; other site 426430002908 heterodimer interface [polypeptide binding]; other site 426430002909 phosphorylation loop region [posttranslational modification] 426430002910 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 426430002911 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 426430002912 alpha subunit interface [polypeptide binding]; other site 426430002913 TPP binding site [chemical binding]; other site 426430002914 heterodimer interface [polypeptide binding]; other site 426430002915 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 426430002916 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 426430002917 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426430002918 E3 interaction surface; other site 426430002919 lipoyl attachment site [posttranslational modification]; other site 426430002920 e3 binding domain; Region: E3_binding; pfam02817 426430002921 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 426430002922 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 426430002923 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426430002924 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426430002925 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426430002926 hypothetical protein; Provisional; Region: PRK04387 426430002927 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426430002928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426430002929 non-specific DNA binding site [nucleotide binding]; other site 426430002930 salt bridge; other site 426430002931 sequence-specific DNA binding site [nucleotide binding]; other site 426430002932 Cupin domain; Region: Cupin_2; pfam07883 426430002933 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 426430002934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426430002935 Walker A/P-loop; other site 426430002936 ATP binding site [chemical binding]; other site 426430002937 Q-loop/lid; other site 426430002938 ABC transporter signature motif; other site 426430002939 Walker B; other site 426430002940 D-loop; other site 426430002941 H-loop/switch region; other site 426430002942 TOBE domain; Region: TOBE_2; pfam08402 426430002943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430002944 putative PBP binding loops; other site 426430002945 dimer interface [polypeptide binding]; other site 426430002946 ABC-ATPase subunit interface; other site 426430002947 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 426430002948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430002949 dimer interface [polypeptide binding]; other site 426430002950 conserved gate region; other site 426430002951 putative PBP binding loops; other site 426430002952 ABC-ATPase subunit interface; other site 426430002953 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 426430002954 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 426430002955 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426430002956 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 426430002957 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 426430002958 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 426430002959 manganese transport protein MntH; Reviewed; Region: PRK00701 426430002960 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 426430002961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 426430002962 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 426430002963 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 426430002964 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 426430002965 active site 426430002966 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 426430002967 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 426430002968 G1 box; other site 426430002969 putative GEF interaction site [polypeptide binding]; other site 426430002970 GTP/Mg2+ binding site [chemical binding]; other site 426430002971 Switch I region; other site 426430002972 G2 box; other site 426430002973 G3 box; other site 426430002974 Switch II region; other site 426430002975 G4 box; other site 426430002976 G5 box; other site 426430002977 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 426430002978 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 426430002979 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 426430002980 hypothetical protein; Provisional; Region: PRK13666 426430002981 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 426430002982 pyruvate carboxylase; Reviewed; Region: PRK12999 426430002983 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 426430002984 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 426430002985 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 426430002986 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 426430002987 active site 426430002988 catalytic residues [active] 426430002989 metal binding site [ion binding]; metal-binding site 426430002990 homodimer binding site [polypeptide binding]; other site 426430002991 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 426430002992 carboxyltransferase (CT) interaction site; other site 426430002993 biotinylation site [posttranslational modification]; other site 426430002994 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 426430002995 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 426430002996 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 426430002997 UbiA prenyltransferase family; Region: UbiA; pfam01040 426430002998 Predicted membrane protein [Function unknown]; Region: COG2322 426430002999 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 426430003000 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 426430003001 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 426430003002 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 426430003003 putative active site [active] 426430003004 catalytic site [active] 426430003005 putative metal binding site [ion binding]; other site 426430003006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 426430003007 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 426430003008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430003009 S-adenosylmethionine binding site [chemical binding]; other site 426430003010 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 426430003011 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 426430003012 active site 426430003013 (T/H)XGH motif; other site 426430003014 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 426430003015 hypothetical protein; Provisional; Region: PRK13670 426430003016 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 426430003017 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 426430003018 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426430003019 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426430003020 catalytic residues [active] 426430003021 catalytic nucleophile [active] 426430003022 Presynaptic Site I dimer interface [polypeptide binding]; other site 426430003023 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426430003024 Synaptic Flat tetramer interface [polypeptide binding]; other site 426430003025 Synaptic Site I dimer interface [polypeptide binding]; other site 426430003026 DNA binding site [nucleotide binding] 426430003027 Recombinase; Region: Recombinase; pfam07508 426430003028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426430003029 non-specific DNA binding site [nucleotide binding]; other site 426430003030 salt bridge; other site 426430003031 sequence-specific DNA binding site [nucleotide binding]; other site 426430003032 Predicted transcriptional regulator [Transcription]; Region: COG2932 426430003033 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 426430003034 Catalytic site [active] 426430003035 Prophage antirepressor [Transcription]; Region: COG3617 426430003036 BRO family, N-terminal domain; Region: Bro-N; smart01040 426430003037 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 426430003038 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 426430003039 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 426430003040 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 426430003041 AAA domain; Region: AAA_24; pfam13479 426430003042 Protein of unknown function (DUF968); Region: DUF968; pfam06147 426430003043 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 426430003044 Helix-turn-helix domain; Region: HTH_36; pfam13730 426430003045 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 426430003046 hypothetical protein; Validated; Region: PRK08116 426430003047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430003048 Walker A motif; other site 426430003049 ATP binding site [chemical binding]; other site 426430003050 Walker B motif; other site 426430003051 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 426430003052 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 426430003053 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 426430003054 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 426430003055 YopX protein; Region: YopX; pfam09643 426430003056 dUTPase; Region: dUTPase_2; pfam08761 426430003057 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 426430003058 active site 426430003059 homodimer interface [polypeptide binding]; other site 426430003060 metal binding site [ion binding]; metal-binding site 426430003061 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 426430003062 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 426430003063 Terminase small subunit; Region: Terminase_2; pfam03592 426430003064 phage terminase, large subunit, PBSX family; Region: phage_term_2; TIGR01547 426430003065 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 426430003066 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 426430003067 phage putative head morphogenesis protein, SPP1 gp7 family; Region: phageSPP1_gp7; TIGR01641 426430003068 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 426430003069 Phage capsid family; Region: Phage_capsid; pfam05065 426430003070 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 426430003071 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 426430003072 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 426430003073 Phage protein; Region: DUF3647; pfam12363 426430003074 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 426430003075 Phage-related protein [Function unknown]; Region: COG5412 426430003076 membrane protein P6; Region: PHA01399 426430003077 Phage tail protein; Region: Sipho_tail; pfam05709 426430003078 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 426430003079 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 426430003080 active site 426430003081 catalytic triad [active] 426430003082 oxyanion hole [active] 426430003083 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 426430003084 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 426430003085 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 426430003086 CHAP domain; Region: CHAP; pfam05257 426430003087 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 426430003088 Lysozyme subfamily 2; Region: LYZ2; smart00047 426430003089 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 426430003090 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 426430003091 Bacteriophage holin; Region: Phage_holin_1; pfam04531 426430003092 CHAP domain; Region: CHAP; pfam05257 426430003093 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 426430003094 amidase catalytic site [active] 426430003095 Zn binding residues [ion binding]; other site 426430003096 substrate binding site [chemical binding]; other site 426430003097 Bacterial SH3 domain; Region: SH3_5; pfam08460 426430003098 heme uptake protein IsdB; Region: IsdB; TIGR03657 426430003099 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 426430003100 NEAr Transporter domain; Region: NEAT; smart00725 426430003101 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 426430003102 heme-binding site [chemical binding]; other site 426430003103 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 426430003104 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 426430003105 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 426430003106 heme-binding site [chemical binding]; other site 426430003107 heme uptake protein IsdC; Region: IsdC; TIGR03656 426430003108 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 426430003109 heme-binding site [chemical binding]; other site 426430003110 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 426430003111 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 426430003112 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 426430003113 intersubunit interface [polypeptide binding]; other site 426430003114 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 426430003115 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426430003116 ABC-ATPase subunit interface; other site 426430003117 dimer interface [polypeptide binding]; other site 426430003118 putative PBP binding regions; other site 426430003119 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 426430003120 active site 426430003121 catalytic site [active] 426430003122 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 426430003123 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 426430003124 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 426430003125 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 426430003126 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 426430003127 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 426430003128 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 426430003129 dimer interface [polypeptide binding]; other site 426430003130 motif 1; other site 426430003131 active site 426430003132 motif 2; other site 426430003133 motif 3; other site 426430003134 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 426430003135 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 426430003136 putative tRNA-binding site [nucleotide binding]; other site 426430003137 B3/4 domain; Region: B3_4; pfam03483 426430003138 tRNA synthetase B5 domain; Region: B5; smart00874 426430003139 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 426430003140 dimer interface [polypeptide binding]; other site 426430003141 motif 1; other site 426430003142 motif 3; other site 426430003143 motif 2; other site 426430003144 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 426430003145 ribonuclease HIII; Provisional; Region: PRK00996 426430003146 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 426430003147 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 426430003148 RNA/DNA hybrid binding site [nucleotide binding]; other site 426430003149 active site 426430003150 Cell division protein ZapA; Region: ZapA; cl01146 426430003151 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 426430003152 Colicin V production protein; Region: Colicin_V; pfam02674 426430003153 hypothetical protein; Provisional; Region: PRK08609 426430003154 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 426430003155 active site 426430003156 primer binding site [nucleotide binding]; other site 426430003157 NTP binding site [chemical binding]; other site 426430003158 metal binding triad [ion binding]; metal-binding site 426430003159 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 426430003160 active site 426430003161 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 426430003162 MutS domain III; Region: MutS_III; pfam05192 426430003163 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 426430003164 Walker A/P-loop; other site 426430003165 ATP binding site [chemical binding]; other site 426430003166 Q-loop/lid; other site 426430003167 ABC transporter signature motif; other site 426430003168 Walker B; other site 426430003169 D-loop; other site 426430003170 H-loop/switch region; other site 426430003171 Smr domain; Region: Smr; pfam01713 426430003172 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 426430003173 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 426430003174 catalytic residues [active] 426430003175 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 426430003176 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 426430003177 GIY-YIG motif/motif A; other site 426430003178 active site 426430003179 catalytic site [active] 426430003180 putative DNA binding site [nucleotide binding]; other site 426430003181 metal binding site [ion binding]; metal-binding site 426430003182 UvrB/uvrC motif; Region: UVR; pfam02151 426430003183 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 426430003184 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 426430003185 putative Iron-sulfur protein interface [polypeptide binding]; other site 426430003186 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 426430003187 proximal heme binding site [chemical binding]; other site 426430003188 distal heme binding site [chemical binding]; other site 426430003189 putative dimer interface [polypeptide binding]; other site 426430003190 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 426430003191 L-aspartate oxidase; Provisional; Region: PRK06175 426430003192 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 426430003193 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 426430003194 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 426430003195 glutamate racemase; Provisional; Region: PRK00865 426430003196 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 426430003197 active site 426430003198 dimerization interface [polypeptide binding]; other site 426430003199 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 426430003200 active site 426430003201 metal binding site [ion binding]; metal-binding site 426430003202 homotetramer interface [polypeptide binding]; other site 426430003203 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 426430003204 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 426430003205 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 426430003206 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 426430003207 beta-channel forming cytolysin; Region: hlyII; TIGR01002 426430003208 superantigen-like protein; Reviewed; Region: PRK13350 426430003209 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430003210 superantigen-like protein; Reviewed; Region: PRK13349 426430003211 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430003212 superantigen-like protein; Reviewed; Region: PRK13043 426430003213 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430003214 ornithine carbamoyltransferase; Provisional; Region: PRK04284 426430003215 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 426430003216 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 426430003217 carbamate kinase; Reviewed; Region: PRK12686 426430003218 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 426430003219 putative substrate binding site [chemical binding]; other site 426430003220 nucleotide binding site [chemical binding]; other site 426430003221 nucleotide binding site [chemical binding]; other site 426430003222 homodimer interface [polypeptide binding]; other site 426430003223 Predicted membrane protein [Function unknown]; Region: COG1288 426430003224 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 426430003225 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 426430003226 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 426430003227 gating phenylalanine in ion channel; other site 426430003228 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 426430003229 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 426430003230 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430003231 motif II; other site 426430003232 hypothetical protein; Provisional; Region: PRK13688 426430003233 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 426430003234 Coenzyme A binding pocket [chemical binding]; other site 426430003235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 426430003236 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 426430003237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 426430003238 MraZ protein; Region: MraZ; pfam02381 426430003239 MraZ protein; Region: MraZ; pfam02381 426430003240 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 426430003241 MraW methylase family; Region: Methyltransf_5; pfam01795 426430003242 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 426430003243 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 426430003244 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 426430003245 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 426430003246 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 426430003247 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 426430003248 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 426430003249 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 426430003250 Mg++ binding site [ion binding]; other site 426430003251 putative catalytic motif [active] 426430003252 putative substrate binding site [chemical binding]; other site 426430003253 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 426430003254 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 426430003255 NAD binding site [chemical binding]; other site 426430003256 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426430003257 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 426430003258 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 426430003259 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 426430003260 Cell division protein FtsQ; Region: FtsQ; pfam03799 426430003261 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 426430003262 Cell division protein FtsA; Region: FtsA; smart00842 426430003263 Cell division protein FtsA; Region: FtsA; pfam14450 426430003264 cell division protein FtsZ; Validated; Region: PRK09330 426430003265 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 426430003266 nucleotide binding site [chemical binding]; other site 426430003267 SulA interaction site; other site 426430003268 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 426430003269 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 426430003270 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 426430003271 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426430003272 catalytic residue [active] 426430003273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 426430003274 YGGT family; Region: YGGT; pfam02325 426430003275 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 426430003276 S4 RNA-binding domain; Region: S4; smart00363 426430003277 RNA binding surface [nucleotide binding]; other site 426430003278 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 426430003279 DivIVA domain; Region: DivI1A_domain; TIGR03544 426430003280 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 426430003281 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 426430003282 HIGH motif; other site 426430003283 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 426430003284 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 426430003285 active site 426430003286 KMSKS motif; other site 426430003287 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 426430003288 tRNA binding surface [nucleotide binding]; other site 426430003289 anticodon binding site; other site 426430003290 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 426430003291 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 426430003292 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 426430003293 active site 426430003294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 426430003295 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 426430003296 lipoprotein signal peptidase; Provisional; Region: PRK14787 426430003297 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 426430003298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426430003299 RNA binding surface [nucleotide binding]; other site 426430003300 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 426430003301 active site 426430003302 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 426430003303 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 426430003304 uracil transporter; Provisional; Region: PRK10720 426430003305 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 426430003306 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 426430003307 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 426430003308 dihydroorotase; Validated; Region: pyrC; PRK09357 426430003309 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426430003310 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 426430003311 active site 426430003312 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 426430003313 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 426430003314 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 426430003315 catalytic site [active] 426430003316 subunit interface [polypeptide binding]; other site 426430003317 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 426430003318 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 426430003319 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 426430003320 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 426430003321 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 426430003322 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426430003323 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 426430003324 IMP binding site; other site 426430003325 dimer interface [polypeptide binding]; other site 426430003326 interdomain contacts; other site 426430003327 partial ornithine binding site; other site 426430003328 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 426430003329 active site 426430003330 dimer interface [polypeptide binding]; other site 426430003331 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426430003332 active site 426430003333 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 426430003334 dimer interface [polypeptide binding]; other site 426430003335 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 426430003336 Domain of unknown function (DUF814); Region: DUF814; pfam05670 426430003337 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 426430003338 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 426430003339 catalytic site [active] 426430003340 G-X2-G-X-G-K; other site 426430003341 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 426430003342 Flavoprotein; Region: Flavoprotein; pfam02441 426430003343 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 426430003344 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 426430003345 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426430003346 ATP binding site [chemical binding]; other site 426430003347 putative Mg++ binding site [ion binding]; other site 426430003348 helicase superfamily c-terminal domain; Region: HELICc; smart00490 426430003349 nucleotide binding region [chemical binding]; other site 426430003350 ATP-binding site [chemical binding]; other site 426430003351 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 426430003352 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 426430003353 active site 426430003354 catalytic residues [active] 426430003355 metal binding site [ion binding]; metal-binding site 426430003356 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 426430003357 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 426430003358 putative active site [active] 426430003359 substrate binding site [chemical binding]; other site 426430003360 putative cosubstrate binding site; other site 426430003361 catalytic site [active] 426430003362 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 426430003363 substrate binding site [chemical binding]; other site 426430003364 16S rRNA methyltransferase B; Provisional; Region: PRK14902 426430003365 NusB family; Region: NusB; pfam01029 426430003366 putative RNA binding site [nucleotide binding]; other site 426430003367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430003368 S-adenosylmethionine binding site [chemical binding]; other site 426430003369 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 426430003370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426430003371 FeS/SAM binding site; other site 426430003372 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 426430003373 Protein phosphatase 2C; Region: PP2C; pfam00481 426430003374 active site 426430003375 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 426430003376 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 426430003377 active site 426430003378 ATP binding site [chemical binding]; other site 426430003379 substrate binding site [chemical binding]; other site 426430003380 activation loop (A-loop); other site 426430003381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 426430003382 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 426430003383 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 426430003384 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 426430003385 Predicted GTPases [General function prediction only]; Region: COG1162 426430003386 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 426430003387 RNA binding site [nucleotide binding]; other site 426430003388 homodimer interface [polypeptide binding]; other site 426430003389 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 426430003390 GTPase/Zn-binding domain interface [polypeptide binding]; other site 426430003391 GTP/Mg2+ binding site [chemical binding]; other site 426430003392 G4 box; other site 426430003393 G5 box; other site 426430003394 G1 box; other site 426430003395 Switch I region; other site 426430003396 G2 box; other site 426430003397 G3 box; other site 426430003398 Switch II region; other site 426430003399 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 426430003400 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 426430003401 substrate binding site [chemical binding]; other site 426430003402 hexamer interface [polypeptide binding]; other site 426430003403 metal binding site [ion binding]; metal-binding site 426430003404 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 426430003405 Thiamine pyrophosphokinase; Region: TPK; cd07995 426430003406 active site 426430003407 dimerization interface [polypeptide binding]; other site 426430003408 thiamine binding site [chemical binding]; other site 426430003409 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 426430003410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 426430003411 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 426430003412 DAK2 domain; Region: Dak2; pfam02734 426430003413 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 426430003414 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 426430003415 generic binding surface II; other site 426430003416 ssDNA binding site; other site 426430003417 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426430003418 ATP binding site [chemical binding]; other site 426430003419 putative Mg++ binding site [ion binding]; other site 426430003420 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426430003421 nucleotide binding region [chemical binding]; other site 426430003422 ATP-binding site [chemical binding]; other site 426430003423 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 426430003424 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 426430003425 active site 2 [active] 426430003426 active site 1 [active] 426430003427 putative phosphate acyltransferase; Provisional; Region: PRK05331 426430003428 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 426430003429 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 426430003430 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 426430003431 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 426430003432 NAD(P) binding site [chemical binding]; other site 426430003433 homotetramer interface [polypeptide binding]; other site 426430003434 homodimer interface [polypeptide binding]; other site 426430003435 active site 426430003436 acyl carrier protein; Provisional; Region: acpP; PRK00982 426430003437 ribonuclease III; Reviewed; Region: rnc; PRK00102 426430003438 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 426430003439 dimerization interface [polypeptide binding]; other site 426430003440 active site 426430003441 metal binding site [ion binding]; metal-binding site 426430003442 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 426430003443 dsRNA binding site [nucleotide binding]; other site 426430003444 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 426430003445 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 426430003446 Walker A/P-loop; other site 426430003447 ATP binding site [chemical binding]; other site 426430003448 Q-loop/lid; other site 426430003449 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 426430003450 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 426430003451 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 426430003452 ABC transporter signature motif; other site 426430003453 Walker B; other site 426430003454 D-loop; other site 426430003455 H-loop/switch region; other site 426430003456 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 426430003457 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 426430003458 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 426430003459 P loop; other site 426430003460 GTP binding site [chemical binding]; other site 426430003461 putative DNA-binding protein; Validated; Region: PRK00118 426430003462 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 426430003463 signal recognition particle protein; Provisional; Region: PRK10867 426430003464 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 426430003465 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 426430003466 P loop; other site 426430003467 GTP binding site [chemical binding]; other site 426430003468 Signal peptide binding domain; Region: SRP_SPB; pfam02978 426430003469 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 426430003470 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 426430003471 RimM N-terminal domain; Region: RimM; pfam01782 426430003472 PRC-barrel domain; Region: PRC; pfam05239 426430003473 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 426430003474 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 426430003475 Predicted membrane protein [Function unknown]; Region: COG4485 426430003476 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 426430003477 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 426430003478 GTP/Mg2+ binding site [chemical binding]; other site 426430003479 G4 box; other site 426430003480 G5 box; other site 426430003481 G1 box; other site 426430003482 Switch I region; other site 426430003483 G2 box; other site 426430003484 G3 box; other site 426430003485 Switch II region; other site 426430003486 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 426430003487 RNA/DNA hybrid binding site [nucleotide binding]; other site 426430003488 active site 426430003489 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 426430003490 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 426430003491 CoA-ligase; Region: Ligase_CoA; pfam00549 426430003492 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 426430003493 CoA binding domain; Region: CoA_binding; pfam02629 426430003494 CoA-ligase; Region: Ligase_CoA; pfam00549 426430003495 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 426430003496 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 426430003497 CHAP domain; Region: CHAP; pfam05257 426430003498 FemAB family; Region: FemAB; pfam02388 426430003499 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 426430003500 DNA protecting protein DprA; Region: dprA; TIGR00732 426430003501 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 426430003502 DNA topoisomerase I; Validated; Region: PRK05582 426430003503 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 426430003504 active site 426430003505 interdomain interaction site; other site 426430003506 putative metal-binding site [ion binding]; other site 426430003507 nucleotide binding site [chemical binding]; other site 426430003508 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 426430003509 domain I; other site 426430003510 DNA binding groove [nucleotide binding] 426430003511 phosphate binding site [ion binding]; other site 426430003512 domain II; other site 426430003513 domain III; other site 426430003514 nucleotide binding site [chemical binding]; other site 426430003515 catalytic site [active] 426430003516 domain IV; other site 426430003517 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 426430003518 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 426430003519 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 426430003520 Glucose inhibited division protein A; Region: GIDA; pfam01134 426430003521 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 426430003522 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426430003523 active site 426430003524 DNA binding site [nucleotide binding] 426430003525 Int/Topo IB signature motif; other site 426430003526 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 426430003527 active site 426430003528 HslU subunit interaction site [polypeptide binding]; other site 426430003529 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 426430003530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430003531 Walker A motif; other site 426430003532 ATP binding site [chemical binding]; other site 426430003533 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 426430003534 Walker B motif; other site 426430003535 arginine finger; other site 426430003536 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 426430003537 transcriptional repressor CodY; Validated; Region: PRK04158 426430003538 CodY GAF-like domain; Region: CodY; pfam06018 426430003539 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 426430003540 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 426430003541 rRNA interaction site [nucleotide binding]; other site 426430003542 S8 interaction site; other site 426430003543 putative laminin-1 binding site; other site 426430003544 elongation factor Ts; Provisional; Region: tsf; PRK09377 426430003545 UBA/TS-N domain; Region: UBA; pfam00627 426430003546 Elongation factor TS; Region: EF_TS; pfam00889 426430003547 Elongation factor TS; Region: EF_TS; pfam00889 426430003548 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 426430003549 putative nucleotide binding site [chemical binding]; other site 426430003550 uridine monophosphate binding site [chemical binding]; other site 426430003551 homohexameric interface [polypeptide binding]; other site 426430003552 ribosome recycling factor; Reviewed; Region: frr; PRK00083 426430003553 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 426430003554 hinge region; other site 426430003555 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 426430003556 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 426430003557 catalytic residue [active] 426430003558 putative FPP diphosphate binding site; other site 426430003559 putative FPP binding hydrophobic cleft; other site 426430003560 dimer interface [polypeptide binding]; other site 426430003561 putative IPP diphosphate binding site; other site 426430003562 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 426430003563 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 426430003564 RIP metalloprotease RseP; Region: TIGR00054 426430003565 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 426430003566 active site 426430003567 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 426430003568 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 426430003569 protein binding site [polypeptide binding]; other site 426430003570 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 426430003571 putative substrate binding region [chemical binding]; other site 426430003572 prolyl-tRNA synthetase; Provisional; Region: PRK09194 426430003573 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 426430003574 dimer interface [polypeptide binding]; other site 426430003575 motif 1; other site 426430003576 active site 426430003577 motif 2; other site 426430003578 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 426430003579 putative deacylase active site [active] 426430003580 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426430003581 active site 426430003582 motif 3; other site 426430003583 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 426430003584 anticodon binding site; other site 426430003585 DNA polymerase III PolC; Validated; Region: polC; PRK00448 426430003586 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 426430003587 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 426430003588 generic binding surface II; other site 426430003589 generic binding surface I; other site 426430003590 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 426430003591 active site 426430003592 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 426430003593 active site 426430003594 catalytic site [active] 426430003595 substrate binding site [chemical binding]; other site 426430003596 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 426430003597 ribosome maturation protein RimP; Reviewed; Region: PRK00092 426430003598 Sm and related proteins; Region: Sm_like; cl00259 426430003599 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 426430003600 putative oligomer interface [polypeptide binding]; other site 426430003601 putative RNA binding site [nucleotide binding]; other site 426430003602 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 426430003603 NusA N-terminal domain; Region: NusA_N; pfam08529 426430003604 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 426430003605 RNA binding site [nucleotide binding]; other site 426430003606 homodimer interface [polypeptide binding]; other site 426430003607 NusA-like KH domain; Region: KH_5; pfam13184 426430003608 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 426430003609 G-X-X-G motif; other site 426430003610 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 426430003611 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 426430003612 translation initiation factor IF-2; Region: IF-2; TIGR00487 426430003613 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 426430003614 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 426430003615 G1 box; other site 426430003616 putative GEF interaction site [polypeptide binding]; other site 426430003617 GTP/Mg2+ binding site [chemical binding]; other site 426430003618 Switch I region; other site 426430003619 G2 box; other site 426430003620 G3 box; other site 426430003621 Switch II region; other site 426430003622 G4 box; other site 426430003623 G5 box; other site 426430003624 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 426430003625 Translation-initiation factor 2; Region: IF-2; pfam11987 426430003626 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 426430003627 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 426430003628 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 426430003629 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 426430003630 RNA binding site [nucleotide binding]; other site 426430003631 active site 426430003632 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 426430003633 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 426430003634 active site 426430003635 Riboflavin kinase; Region: Flavokinase; smart00904 426430003636 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 426430003637 16S/18S rRNA binding site [nucleotide binding]; other site 426430003638 S13e-L30e interaction site [polypeptide binding]; other site 426430003639 25S rRNA binding site [nucleotide binding]; other site 426430003640 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 426430003641 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 426430003642 RNase E interface [polypeptide binding]; other site 426430003643 trimer interface [polypeptide binding]; other site 426430003644 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 426430003645 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 426430003646 RNase E interface [polypeptide binding]; other site 426430003647 trimer interface [polypeptide binding]; other site 426430003648 active site 426430003649 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 426430003650 putative nucleic acid binding region [nucleotide binding]; other site 426430003651 G-X-X-G motif; other site 426430003652 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 426430003653 RNA binding site [nucleotide binding]; other site 426430003654 domain interface; other site 426430003655 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 426430003656 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426430003657 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 426430003658 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 426430003659 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 426430003660 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426430003661 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426430003662 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 426430003663 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 426430003664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 426430003665 DNA-binding site [nucleotide binding]; DNA binding site 426430003666 UTRA domain; Region: UTRA; pfam07702 426430003667 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 426430003668 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 426430003669 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 426430003670 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 426430003671 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 426430003672 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 426430003673 classical (c) SDRs; Region: SDR_c; cd05233 426430003674 NAD(P) binding site [chemical binding]; other site 426430003675 active site 426430003676 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 426430003677 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 426430003678 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 426430003679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426430003680 non-specific DNA binding site [nucleotide binding]; other site 426430003681 salt bridge; other site 426430003682 sequence-specific DNA binding site [nucleotide binding]; other site 426430003683 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 426430003684 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 426430003685 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 426430003686 putative MPT binding site; other site 426430003687 recombinase A; Provisional; Region: recA; PRK09354 426430003688 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 426430003689 hexamer interface [polypeptide binding]; other site 426430003690 Walker A motif; other site 426430003691 ATP binding site [chemical binding]; other site 426430003692 Walker B motif; other site 426430003693 phosphodiesterase; Provisional; Region: PRK12704 426430003694 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426430003695 Zn2+ binding site [ion binding]; other site 426430003696 Mg2+ binding site [ion binding]; other site 426430003697 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 426430003698 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426430003699 putative active site [active] 426430003700 metal binding site [ion binding]; metal-binding site 426430003701 homodimer binding site [polypeptide binding]; other site 426430003702 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 426430003703 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 426430003704 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 426430003705 dimer interface [polypeptide binding]; other site 426430003706 PYR/PP interface [polypeptide binding]; other site 426430003707 TPP binding site [chemical binding]; other site 426430003708 substrate binding site [chemical binding]; other site 426430003709 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 426430003710 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 426430003711 TPP-binding site [chemical binding]; other site 426430003712 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 426430003713 Uncharacterized conserved protein [Function unknown]; Region: COG0011 426430003714 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 426430003715 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 426430003716 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426430003717 FeS/SAM binding site; other site 426430003718 TRAM domain; Region: TRAM; pfam01938 426430003719 Predicted membrane protein [Function unknown]; Region: COG4550 426430003720 Predicted membrane protein [Function unknown]; Region: COG4732 426430003721 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 426430003722 MutS domain I; Region: MutS_I; pfam01624 426430003723 MutS domain II; Region: MutS_II; pfam05188 426430003724 MutS domain III; Region: MutS_III; pfam05192 426430003725 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 426430003726 Walker A/P-loop; other site 426430003727 ATP binding site [chemical binding]; other site 426430003728 Q-loop/lid; other site 426430003729 ABC transporter signature motif; other site 426430003730 Walker B; other site 426430003731 D-loop; other site 426430003732 H-loop/switch region; other site 426430003733 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 426430003734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430003735 ATP binding site [chemical binding]; other site 426430003736 Mg2+ binding site [ion binding]; other site 426430003737 G-X-G motif; other site 426430003738 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 426430003739 ATP binding site [chemical binding]; other site 426430003740 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 426430003741 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 426430003742 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 426430003743 amphipathic channel; other site 426430003744 Asn-Pro-Ala signature motifs; other site 426430003745 glycerol kinase; Provisional; Region: glpK; PRK00047 426430003746 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 426430003747 N- and C-terminal domain interface [polypeptide binding]; other site 426430003748 active site 426430003749 MgATP binding site [chemical binding]; other site 426430003750 catalytic site [active] 426430003751 metal binding site [ion binding]; metal-binding site 426430003752 glycerol binding site [chemical binding]; other site 426430003753 homotetramer interface [polypeptide binding]; other site 426430003754 homodimer interface [polypeptide binding]; other site 426430003755 FBP binding site [chemical binding]; other site 426430003756 protein IIAGlc interface [polypeptide binding]; other site 426430003757 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 426430003758 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 426430003759 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426430003760 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 426430003761 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 426430003762 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 426430003763 bacterial Hfq-like; Region: Hfq; cd01716 426430003764 hexamer interface [polypeptide binding]; other site 426430003765 Sm1 motif; other site 426430003766 RNA binding site [nucleotide binding]; other site 426430003767 Sm2 motif; other site 426430003768 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 426430003769 catalytic residues [active] 426430003770 dimer interface [polypeptide binding]; other site 426430003771 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 426430003772 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 426430003773 HflX GTPase family; Region: HflX; cd01878 426430003774 G1 box; other site 426430003775 GTP/Mg2+ binding site [chemical binding]; other site 426430003776 Switch I region; other site 426430003777 G2 box; other site 426430003778 G3 box; other site 426430003779 Switch II region; other site 426430003780 G4 box; other site 426430003781 G5 box; other site 426430003782 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 426430003783 Aluminium resistance protein; Region: Alum_res; pfam06838 426430003784 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 426430003785 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 426430003786 DNA binding residues [nucleotide binding] 426430003787 putative dimer interface [polypeptide binding]; other site 426430003788 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 426430003789 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 426430003790 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 426430003791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 426430003792 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 426430003793 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 426430003794 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426430003795 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426430003796 catalytic residue [active] 426430003797 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 426430003798 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 426430003799 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 426430003800 putative active site [active] 426430003801 catalytic site [active] 426430003802 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 426430003803 putative active site [active] 426430003804 catalytic site [active] 426430003805 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 426430003806 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 426430003807 Walker A/P-loop; other site 426430003808 ATP binding site [chemical binding]; other site 426430003809 Q-loop/lid; other site 426430003810 ABC transporter signature motif; other site 426430003811 Walker B; other site 426430003812 D-loop; other site 426430003813 H-loop/switch region; other site 426430003814 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 426430003815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 426430003816 Histidine kinase; Region: HisKA_3; pfam07730 426430003817 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 426430003818 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426430003819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430003820 active site 426430003821 phosphorylation site [posttranslational modification] 426430003822 intermolecular recognition site; other site 426430003823 dimerization interface [polypeptide binding]; other site 426430003824 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426430003825 DNA binding residues [nucleotide binding] 426430003826 dimerization interface [polypeptide binding]; other site 426430003827 Staphylococcal nuclease homologues; Region: SNc; smart00318 426430003828 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 426430003829 Catalytic site; other site 426430003830 AAA domain; Region: AAA_11; pfam13086 426430003831 aspartate kinase; Reviewed; Region: PRK09034 426430003832 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 426430003833 putative catalytic residues [active] 426430003834 putative nucleotide binding site [chemical binding]; other site 426430003835 putative aspartate binding site [chemical binding]; other site 426430003836 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 426430003837 allosteric regulatory residue; other site 426430003838 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 426430003839 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 426430003840 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 426430003841 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 426430003842 threonine synthase; Reviewed; Region: PRK06721 426430003843 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 426430003844 homodimer interface [polypeptide binding]; other site 426430003845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430003846 catalytic residue [active] 426430003847 homoserine kinase; Provisional; Region: PRK01212 426430003848 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 426430003849 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 426430003850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430003851 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 426430003852 active site 426430003853 motif I; other site 426430003854 motif II; other site 426430003855 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 426430003856 lysine transporter; Provisional; Region: PRK10836 426430003857 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 426430003858 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 426430003859 tetramer interface [polypeptide binding]; other site 426430003860 heme binding pocket [chemical binding]; other site 426430003861 NADPH binding site [chemical binding]; other site 426430003862 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 426430003863 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 426430003864 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 426430003865 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 426430003866 active site 426430003867 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 426430003868 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 426430003869 LexA repressor; Validated; Region: PRK00215 426430003870 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426430003871 putative DNA binding site [nucleotide binding]; other site 426430003872 putative Zn2+ binding site [ion binding]; other site 426430003873 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 426430003874 Catalytic site [active] 426430003875 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 426430003876 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 426430003877 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 426430003878 TPP-binding site [chemical binding]; other site 426430003879 dimer interface [polypeptide binding]; other site 426430003880 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 426430003881 PYR/PP interface [polypeptide binding]; other site 426430003882 dimer interface [polypeptide binding]; other site 426430003883 TPP binding site [chemical binding]; other site 426430003884 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 426430003885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 426430003886 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 426430003887 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 426430003888 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 426430003889 active site 426430003890 metal binding site [ion binding]; metal-binding site 426430003891 DNA binding site [nucleotide binding] 426430003892 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 426430003893 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 426430003894 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 426430003895 Walker A/P-loop; other site 426430003896 ATP binding site [chemical binding]; other site 426430003897 Q-loop/lid; other site 426430003898 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 426430003899 ABC transporter signature motif; other site 426430003900 Walker B; other site 426430003901 D-loop; other site 426430003902 H-loop/switch region; other site 426430003903 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 426430003904 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 426430003905 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 426430003906 aconitate hydratase; Validated; Region: PRK09277 426430003907 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 426430003908 substrate binding site [chemical binding]; other site 426430003909 ligand binding site [chemical binding]; other site 426430003910 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 426430003911 substrate binding site [chemical binding]; other site 426430003912 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 426430003913 active site 426430003914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 426430003915 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 426430003916 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 426430003917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430003918 ATP binding site [chemical binding]; other site 426430003919 Mg2+ binding site [ion binding]; other site 426430003920 G-X-G motif; other site 426430003921 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 426430003922 anchoring element; other site 426430003923 dimer interface [polypeptide binding]; other site 426430003924 ATP binding site [chemical binding]; other site 426430003925 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 426430003926 active site 426430003927 putative metal-binding site [ion binding]; other site 426430003928 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 426430003929 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 426430003930 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 426430003931 CAP-like domain; other site 426430003932 active site 426430003933 primary dimer interface [polypeptide binding]; other site 426430003934 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426430003935 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 426430003936 amino acid carrier protein; Region: agcS; TIGR00835 426430003937 CAT RNA binding domain; Region: CAT_RBD; smart01061 426430003938 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 426430003939 PRD domain; Region: PRD; pfam00874 426430003940 PRD domain; Region: PRD; pfam00874 426430003941 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 426430003942 Domain of unknown function DUF20; Region: UPF0118; pfam01594 426430003943 Predicted integral membrane protein [Function unknown]; Region: COG0392 426430003944 Uncharacterized conserved protein [Function unknown]; Region: COG2898 426430003945 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 426430003946 methionine sulfoxide reductase A; Provisional; Region: PRK14054 426430003947 Transcriptional regulator [Transcription]; Region: LytR; COG1316 426430003948 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 426430003949 active site 1 [active] 426430003950 dimer interface [polypeptide binding]; other site 426430003951 hexamer interface [polypeptide binding]; other site 426430003952 active site 2 [active] 426430003953 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 426430003954 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 426430003955 active site 426430003956 DNA binding site [nucleotide binding] 426430003957 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 426430003958 prephenate dehydrogenase; Validated; Region: PRK06545 426430003959 prephenate dehydrogenase; Validated; Region: PRK08507 426430003960 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 426430003961 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 426430003962 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 426430003963 putative oligomer interface [polypeptide binding]; other site 426430003964 putative active site [active] 426430003965 metal binding site [ion binding]; metal-binding site 426430003966 anthranilate synthase component I; Provisional; Region: PRK13567 426430003967 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 426430003968 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 426430003969 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 426430003970 Glutamine amidotransferase class-I; Region: GATase; pfam00117 426430003971 glutamine binding [chemical binding]; other site 426430003972 catalytic triad [active] 426430003973 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 426430003974 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 426430003975 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 426430003976 active site 426430003977 ribulose/triose binding site [chemical binding]; other site 426430003978 phosphate binding site [ion binding]; other site 426430003979 substrate (anthranilate) binding pocket [chemical binding]; other site 426430003980 product (indole) binding pocket [chemical binding]; other site 426430003981 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 426430003982 active site 426430003983 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 426430003984 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 426430003985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430003986 catalytic residue [active] 426430003987 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 426430003988 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 426430003989 substrate binding site [chemical binding]; other site 426430003990 active site 426430003991 catalytic residues [active] 426430003992 heterodimer interface [polypeptide binding]; other site 426430003993 FemAB family; Region: FemAB; pfam02388 426430003994 FlxA-like protein; Region: FlxA; pfam14282 426430003995 FemAB family; Region: FemAB; pfam02388 426430003996 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 426430003997 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430003998 active site 426430003999 motif I; other site 426430004000 motif II; other site 426430004001 SWIM zinc finger; Region: SWIM; pfam04434 426430004002 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 426430004003 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426430004004 Walker A/P-loop; other site 426430004005 ATP binding site [chemical binding]; other site 426430004006 Q-loop/lid; other site 426430004007 ABC transporter signature motif; other site 426430004008 Walker B; other site 426430004009 D-loop; other site 426430004010 H-loop/switch region; other site 426430004011 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426430004012 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 426430004013 Walker A/P-loop; other site 426430004014 ATP binding site [chemical binding]; other site 426430004015 Q-loop/lid; other site 426430004016 ABC transporter signature motif; other site 426430004017 Walker B; other site 426430004018 D-loop; other site 426430004019 H-loop/switch region; other site 426430004020 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426430004021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430004022 dimer interface [polypeptide binding]; other site 426430004023 conserved gate region; other site 426430004024 putative PBP binding loops; other site 426430004025 ABC-ATPase subunit interface; other site 426430004026 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426430004027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430004028 dimer interface [polypeptide binding]; other site 426430004029 conserved gate region; other site 426430004030 putative PBP binding loops; other site 426430004031 ABC-ATPase subunit interface; other site 426430004032 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 426430004033 oligoendopeptidase F; Region: pepF; TIGR00181 426430004034 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 426430004035 active site 426430004036 Zn binding site [ion binding]; other site 426430004037 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 426430004038 PhoU domain; Region: PhoU; pfam01895 426430004039 PhoU domain; Region: PhoU; pfam01895 426430004040 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 426430004041 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 426430004042 Walker A/P-loop; other site 426430004043 ATP binding site [chemical binding]; other site 426430004044 Q-loop/lid; other site 426430004045 ABC transporter signature motif; other site 426430004046 Walker B; other site 426430004047 D-loop; other site 426430004048 H-loop/switch region; other site 426430004049 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 426430004050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430004051 dimer interface [polypeptide binding]; other site 426430004052 conserved gate region; other site 426430004053 putative PBP binding loops; other site 426430004054 ABC-ATPase subunit interface; other site 426430004055 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 426430004056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430004057 dimer interface [polypeptide binding]; other site 426430004058 conserved gate region; other site 426430004059 ABC-ATPase subunit interface; other site 426430004060 phosphate binding protein; Region: ptsS_2; TIGR02136 426430004061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 426430004062 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 426430004063 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 426430004064 S1 domain; Region: S1_2; pfam13509 426430004065 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 426430004066 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426430004067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426430004068 ABC transporter; Region: ABC_tran_2; pfam12848 426430004069 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426430004070 aspartate kinase; Reviewed; Region: PRK06635 426430004071 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 426430004072 putative nucleotide binding site [chemical binding]; other site 426430004073 putative catalytic residues [active] 426430004074 putative Mg ion binding site [ion binding]; other site 426430004075 putative aspartate binding site [chemical binding]; other site 426430004076 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 426430004077 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 426430004078 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 426430004079 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 426430004080 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 426430004081 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 426430004082 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 426430004083 dimer interface [polypeptide binding]; other site 426430004084 active site 426430004085 catalytic residue [active] 426430004086 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 426430004087 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 426430004088 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 426430004089 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 426430004090 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 426430004091 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 426430004092 trimer interface [polypeptide binding]; other site 426430004093 active site 426430004094 substrate binding site [chemical binding]; other site 426430004095 CoA binding site [chemical binding]; other site 426430004096 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 426430004097 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 426430004098 metal binding site [ion binding]; metal-binding site 426430004099 dimer interface [polypeptide binding]; other site 426430004100 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 426430004101 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 426430004102 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426430004103 catalytic residue [active] 426430004104 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 426430004105 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 426430004106 active site 426430004107 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426430004108 substrate binding site [chemical binding]; other site 426430004109 catalytic residues [active] 426430004110 dimer interface [polypeptide binding]; other site 426430004111 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426430004112 DNA-binding site [nucleotide binding]; DNA binding site 426430004113 RNA-binding motif; other site 426430004114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 426430004115 acylphosphatase; Provisional; Region: PRK14431 426430004116 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 426430004117 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 426430004118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 426430004119 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 426430004120 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 426430004121 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 426430004122 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 426430004123 metal ion-dependent adhesion site (MIDAS); other site 426430004124 MoxR-like ATPases [General function prediction only]; Region: COG0714 426430004125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430004126 Walker A motif; other site 426430004127 ATP binding site [chemical binding]; other site 426430004128 Walker B motif; other site 426430004129 arginine finger; other site 426430004130 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 426430004131 active site 426430004132 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 426430004133 active site 426430004134 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 426430004135 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426430004136 E3 interaction surface; other site 426430004137 lipoyl attachment site [posttranslational modification]; other site 426430004138 e3 binding domain; Region: E3_binding; pfam02817 426430004139 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 426430004140 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 426430004141 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 426430004142 TPP-binding site [chemical binding]; other site 426430004143 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 426430004144 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 426430004145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426430004146 HAMP domain; Region: HAMP; pfam00672 426430004147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426430004148 dimer interface [polypeptide binding]; other site 426430004149 phosphorylation site [posttranslational modification] 426430004150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430004151 ATP binding site [chemical binding]; other site 426430004152 Mg2+ binding site [ion binding]; other site 426430004153 G-X-G motif; other site 426430004154 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426430004155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430004156 active site 426430004157 phosphorylation site [posttranslational modification] 426430004158 intermolecular recognition site; other site 426430004159 dimerization interface [polypeptide binding]; other site 426430004160 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426430004161 DNA binding site [nucleotide binding] 426430004162 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 426430004163 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 426430004164 active site 426430004165 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 426430004166 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 426430004167 active site 426430004168 homodimer interface [polypeptide binding]; other site 426430004169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430004170 Coenzyme A binding pocket [chemical binding]; other site 426430004171 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 426430004172 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 426430004173 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 426430004174 protein binding site [polypeptide binding]; other site 426430004175 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 426430004176 Catalytic dyad [active] 426430004177 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426430004178 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 426430004179 HPr interaction site; other site 426430004180 glycerol kinase (GK) interaction site [polypeptide binding]; other site 426430004181 active site 426430004182 phosphorylation site [posttranslational modification] 426430004183 methionine sulfoxide reductase B; Provisional; Region: PRK00222 426430004184 SelR domain; Region: SelR; pfam01641 426430004185 methionine sulfoxide reductase A; Provisional; Region: PRK13014 426430004186 EDD domain protein, DegV family; Region: DegV; TIGR00762 426430004187 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 426430004188 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 426430004189 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 426430004190 folate binding site [chemical binding]; other site 426430004191 NADP+ binding site [chemical binding]; other site 426430004192 thymidylate synthase; Region: thym_sym; TIGR03284 426430004193 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 426430004194 dimerization interface [polypeptide binding]; other site 426430004195 active site 426430004196 Disulphide isomerase; Region: Disulph_isomer; pfam06491 426430004197 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 426430004198 Virulence factor; Region: Virulence_fact; pfam13769 426430004199 HEAT repeats; Region: HEAT_2; pfam13646 426430004200 HEAT repeat; Region: HEAT; pfam02985 426430004201 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 426430004202 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 426430004203 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 426430004204 RNA/DNA hybrid binding site [nucleotide binding]; other site 426430004205 active site 426430004206 GA module; Region: GA; cl08325 426430004207 GA module; Region: GA; smart00844 426430004208 GA module; Region: GA; smart00844 426430004209 GA module; Region: GA; smart00844 426430004210 GA module; Region: GA; smart00844 426430004211 GA module; Region: GA; pfam01468 426430004212 GA module; Region: GA; smart00844 426430004213 GA module; Region: GA; smart00844 426430004214 GA module; Region: GA; smart00844 426430004215 GA module; Region: GA; smart00844 426430004216 GA module; Region: GA; smart00844 426430004217 GA module; Region: GA; smart00844 426430004218 GA module; Region: GA; smart00844 426430004219 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 426430004220 GA module; Region: GA; smart00844 426430004221 GA module; Region: GA; smart00844 426430004222 GA module; Region: GA; smart00844 426430004223 GA module; Region: GA; smart00844 426430004224 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430004225 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430004226 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 426430004227 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 426430004228 GA module; Region: GA; smart00844 426430004229 GA module; Region: GA; smart00844 426430004230 GA module; Region: GA; smart00844 426430004231 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 426430004232 GA module; Region: GA; smart00844 426430004233 GA module; Region: GA; smart00844 426430004234 GA module; Region: GA; smart00844 426430004235 GA module; Region: GA; smart00844 426430004236 GA module; Region: GA; smart00844 426430004237 GA module; Region: GA; smart00844 426430004238 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 426430004239 GA module; Region: GA; smart00844 426430004240 GA module; Region: GA; smart00844 426430004241 GA module; Region: GA; smart00844 426430004242 GA module; Region: GA; smart00844 426430004243 GA module; Region: GA; smart00844 426430004244 GA module; Region: GA; smart00844 426430004245 GA module; Region: GA; smart00844 426430004246 GA module; Region: GA; smart00844 426430004247 GA module; Region: GA; smart00844 426430004248 GA module; Region: GA; smart00844 426430004249 GA module; Region: GA; pfam01468 426430004250 GA module; Region: GA; smart00844 426430004251 GA module; Region: GA; smart00844 426430004252 GA module; Region: GA; smart00844 426430004253 GA module; Region: GA; smart00844 426430004254 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 426430004255 GA module; Region: GA; smart00844 426430004256 GA module; Region: GA; smart00844 426430004257 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 426430004258 Amino acid permease; Region: AA_permease_2; pfam13520 426430004259 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 426430004260 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 426430004261 tetramer interface [polypeptide binding]; other site 426430004262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430004263 catalytic residue [active] 426430004264 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 426430004265 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 426430004266 hexamer interface [polypeptide binding]; other site 426430004267 ligand binding site [chemical binding]; other site 426430004268 putative active site [active] 426430004269 NAD(P) binding site [chemical binding]; other site 426430004270 5'-3' exonuclease; Region: 53EXOc; smart00475 426430004271 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 426430004272 active site 426430004273 metal binding site 1 [ion binding]; metal-binding site 426430004274 putative 5' ssDNA interaction site; other site 426430004275 metal binding site 3; metal-binding site 426430004276 metal binding site 2 [ion binding]; metal-binding site 426430004277 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 426430004278 putative DNA binding site [nucleotide binding]; other site 426430004279 putative metal binding site [ion binding]; other site 426430004280 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 426430004281 Dynamin family; Region: Dynamin_N; pfam00350 426430004282 G1 box; other site 426430004283 GTP/Mg2+ binding site [chemical binding]; other site 426430004284 G2 box; other site 426430004285 Switch I region; other site 426430004286 G3 box; other site 426430004287 Switch II region; other site 426430004288 G4 box; other site 426430004289 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 426430004290 Dynamin family; Region: Dynamin_N; pfam00350 426430004291 G1 box; other site 426430004292 GTP/Mg2+ binding site [chemical binding]; other site 426430004293 G2 box; other site 426430004294 Switch I region; other site 426430004295 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 426430004296 G3 box; other site 426430004297 Switch II region; other site 426430004298 GTP/Mg2+ binding site [chemical binding]; other site 426430004299 G4 box; other site 426430004300 G5 box; other site 426430004301 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 426430004302 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 426430004303 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 426430004304 Cobalt transport protein component CbiN; Region: CbiN; cl00842 426430004305 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 426430004306 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 426430004307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426430004308 cell division protein GpsB; Provisional; Region: PRK14127 426430004309 DivIVA domain; Region: DivI1A_domain; TIGR03544 426430004310 hypothetical protein; Provisional; Region: PRK13660 426430004311 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 426430004312 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 426430004313 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 426430004314 Transglycosylase; Region: Transgly; pfam00912 426430004315 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 426430004316 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 426430004317 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 426430004318 minor groove reading motif; other site 426430004319 helix-hairpin-helix signature motif; other site 426430004320 substrate binding pocket [chemical binding]; other site 426430004321 active site 426430004322 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 426430004323 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 426430004324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 426430004325 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 426430004326 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 426430004327 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 426430004328 putative dimer interface [polypeptide binding]; other site 426430004329 putative anticodon binding site; other site 426430004330 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 426430004331 homodimer interface [polypeptide binding]; other site 426430004332 motif 1; other site 426430004333 motif 2; other site 426430004334 active site 426430004335 motif 3; other site 426430004336 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 426430004337 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 426430004338 active site 426430004339 catalytic site [active] 426430004340 substrate binding site [chemical binding]; other site 426430004341 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 426430004342 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 426430004343 Biotin operon repressor [Transcription]; Region: BirA; COG1654 426430004344 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 426430004345 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 426430004346 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 426430004347 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 426430004348 active site 426430004349 NTP binding site [chemical binding]; other site 426430004350 metal binding triad [ion binding]; metal-binding site 426430004351 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 426430004352 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 426430004353 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 426430004354 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 426430004355 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 426430004356 homodimer interface [polypeptide binding]; other site 426430004357 metal binding site [ion binding]; metal-binding site 426430004358 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 426430004359 Predicted membrane protein [Function unknown]; Region: COG4347 426430004360 Uncharacterized conserved protein [Function unknown]; Region: COG5582 426430004361 UPF0302 domain; Region: UPF0302; pfam08864 426430004362 A short protein domain of unknown function; Region: IDEAL; smart00914 426430004363 TPR repeat; Region: TPR_11; pfam13414 426430004364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426430004365 binding surface 426430004366 TPR motif; other site 426430004367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426430004368 TPR motif; other site 426430004369 binding surface 426430004370 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 426430004371 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 426430004372 hinge; other site 426430004373 active site 426430004374 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 426430004375 active site 426430004376 NAD binding site [chemical binding]; other site 426430004377 metal binding site [ion binding]; metal-binding site 426430004378 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 426430004379 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 426430004380 Tetramer interface [polypeptide binding]; other site 426430004381 active site 426430004382 FMN-binding site [chemical binding]; other site 426430004383 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 426430004384 active site 426430004385 multimer interface [polypeptide binding]; other site 426430004386 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 426430004387 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 426430004388 substrate binding pocket [chemical binding]; other site 426430004389 chain length determination region; other site 426430004390 substrate-Mg2+ binding site; other site 426430004391 catalytic residues [active] 426430004392 aspartate-rich region 1; other site 426430004393 active site lid residues [active] 426430004394 aspartate-rich region 2; other site 426430004395 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 426430004396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430004397 S-adenosylmethionine binding site [chemical binding]; other site 426430004398 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 426430004399 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 426430004400 IHF dimer interface [polypeptide binding]; other site 426430004401 IHF - DNA interface [nucleotide binding]; other site 426430004402 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 426430004403 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 426430004404 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 426430004405 GTP-binding protein Der; Reviewed; Region: PRK00093 426430004406 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 426430004407 G1 box; other site 426430004408 GTP/Mg2+ binding site [chemical binding]; other site 426430004409 Switch I region; other site 426430004410 G2 box; other site 426430004411 Switch II region; other site 426430004412 G3 box; other site 426430004413 G4 box; other site 426430004414 G5 box; other site 426430004415 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 426430004416 G1 box; other site 426430004417 GTP/Mg2+ binding site [chemical binding]; other site 426430004418 Switch I region; other site 426430004419 G2 box; other site 426430004420 G3 box; other site 426430004421 Switch II region; other site 426430004422 G4 box; other site 426430004423 G5 box; other site 426430004424 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 426430004425 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 426430004426 RNA binding site [nucleotide binding]; other site 426430004427 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 426430004428 RNA binding site [nucleotide binding]; other site 426430004429 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 426430004430 RNA binding site [nucleotide binding]; other site 426430004431 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 426430004432 RNA binding site [nucleotide binding]; other site 426430004433 cytidylate kinase; Provisional; Region: cmk; PRK00023 426430004434 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 426430004435 CMP-binding site; other site 426430004436 The sites determining sugar specificity; other site 426430004437 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 426430004438 active site 426430004439 homotetramer interface [polypeptide binding]; other site 426430004440 homodimer interface [polypeptide binding]; other site 426430004441 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 426430004442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 426430004443 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426430004444 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 426430004445 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 426430004446 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426430004447 ATP binding site [chemical binding]; other site 426430004448 putative Mg++ binding site [ion binding]; other site 426430004449 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426430004450 nucleotide binding region [chemical binding]; other site 426430004451 ATP-binding site [chemical binding]; other site 426430004452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 426430004453 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 426430004454 Predicted membrane protein [Function unknown]; Region: COG3601 426430004455 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 426430004456 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 426430004457 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 426430004458 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 426430004459 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 426430004460 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 426430004461 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426430004462 dimerization interface [polypeptide binding]; other site 426430004463 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 426430004464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426430004465 dimer interface [polypeptide binding]; other site 426430004466 phosphorylation site [posttranslational modification] 426430004467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430004468 ATP binding site [chemical binding]; other site 426430004469 Mg2+ binding site [ion binding]; other site 426430004470 G-X-G motif; other site 426430004471 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426430004472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430004473 active site 426430004474 phosphorylation site [posttranslational modification] 426430004475 intermolecular recognition site; other site 426430004476 dimerization interface [polypeptide binding]; other site 426430004477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426430004478 DNA binding site [nucleotide binding] 426430004479 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 426430004480 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426430004481 RNA binding surface [nucleotide binding]; other site 426430004482 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 426430004483 active site 426430004484 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 426430004485 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 426430004486 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 426430004487 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 426430004488 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 426430004489 active site 426430004490 Int/Topo IB signature motif; other site 426430004491 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 426430004492 metal binding site 2 [ion binding]; metal-binding site 426430004493 putative DNA binding helix; other site 426430004494 metal binding site 1 [ion binding]; metal-binding site 426430004495 dimer interface [polypeptide binding]; other site 426430004496 structural Zn2+ binding site [ion binding]; other site 426430004497 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 426430004498 dimer interface [polypeptide binding]; other site 426430004499 ADP-ribose binding site [chemical binding]; other site 426430004500 active site 426430004501 nudix motif; other site 426430004502 metal binding site [ion binding]; metal-binding site 426430004503 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426430004504 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426430004505 active site 426430004506 catalytic tetrad [active] 426430004507 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 426430004508 classical (c) SDRs; Region: SDR_c; cd05233 426430004509 NAD(P) binding site [chemical binding]; other site 426430004510 active site 426430004511 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 426430004512 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 426430004513 ribonuclease Z; Region: RNase_Z; TIGR02651 426430004514 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 426430004515 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 426430004516 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 426430004517 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426430004518 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 426430004519 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 426430004520 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 426430004521 Ca binding site [ion binding]; other site 426430004522 active site 426430004523 catalytic site [active] 426430004524 Transcriptional regulators [Transcription]; Region: PurR; COG1609 426430004525 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 426430004526 DNA binding site [nucleotide binding] 426430004527 domain linker motif; other site 426430004528 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 426430004529 putative ligand binding site [chemical binding]; other site 426430004530 putative dimerization interface [polypeptide binding]; other site 426430004531 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426430004532 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 426430004533 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426430004534 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 426430004535 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 426430004536 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 426430004537 peptidase T-like protein; Region: PepT-like; TIGR01883 426430004538 metal binding site [ion binding]; metal-binding site 426430004539 putative dimer interface [polypeptide binding]; other site 426430004540 Predicted membrane protein [Function unknown]; Region: COG4129 426430004541 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 426430004542 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 426430004543 Disulphide isomerase; Region: Disulph_isomer; pfam06491 426430004544 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426430004545 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 426430004546 E3 interaction surface; other site 426430004547 lipoyl attachment site [posttranslational modification]; other site 426430004548 e3 binding domain; Region: E3_binding; pfam02817 426430004549 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 426430004550 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 426430004551 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 426430004552 alpha subunit interface [polypeptide binding]; other site 426430004553 TPP binding site [chemical binding]; other site 426430004554 heterodimer interface [polypeptide binding]; other site 426430004555 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 426430004556 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 426430004557 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 426430004558 tetramer interface [polypeptide binding]; other site 426430004559 TPP-binding site [chemical binding]; other site 426430004560 heterodimer interface [polypeptide binding]; other site 426430004561 phosphorylation loop region [posttranslational modification] 426430004562 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 426430004563 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 426430004564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426430004565 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426430004566 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 426430004567 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 426430004568 Walker A/P-loop; other site 426430004569 ATP binding site [chemical binding]; other site 426430004570 Q-loop/lid; other site 426430004571 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 426430004572 ABC transporter signature motif; other site 426430004573 Walker B; other site 426430004574 D-loop; other site 426430004575 H-loop/switch region; other site 426430004576 arginine repressor; Provisional; Region: PRK04280 426430004577 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 426430004578 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 426430004579 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 426430004580 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 426430004581 substrate binding pocket [chemical binding]; other site 426430004582 chain length determination region; other site 426430004583 substrate-Mg2+ binding site; other site 426430004584 catalytic residues [active] 426430004585 aspartate-rich region 1; other site 426430004586 active site lid residues [active] 426430004587 aspartate-rich region 2; other site 426430004588 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 426430004589 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 426430004590 generic binding surface II; other site 426430004591 generic binding surface I; other site 426430004592 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 426430004593 putative RNA binding site [nucleotide binding]; other site 426430004594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 426430004595 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 426430004596 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 426430004597 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 426430004598 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 426430004599 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 426430004600 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 426430004601 carboxyltransferase (CT) interaction site; other site 426430004602 biotinylation site [posttranslational modification]; other site 426430004603 elongation factor P; Validated; Region: PRK00529 426430004604 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 426430004605 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 426430004606 RNA binding site [nucleotide binding]; other site 426430004607 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 426430004608 RNA binding site [nucleotide binding]; other site 426430004609 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 426430004610 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 426430004611 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 426430004612 active site 426430004613 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 426430004614 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 426430004615 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 426430004616 active site residue [active] 426430004617 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 426430004618 tetramer interface [polypeptide binding]; other site 426430004619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430004620 catalytic residue [active] 426430004621 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 426430004622 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 426430004623 tetramer interface [polypeptide binding]; other site 426430004624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430004625 catalytic residue [active] 426430004626 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 426430004627 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 426430004628 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 426430004629 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 426430004630 ADP binding site [chemical binding]; other site 426430004631 magnesium binding site [ion binding]; other site 426430004632 putative shikimate binding site; other site 426430004633 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 426430004634 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 426430004635 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 426430004636 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 426430004637 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 426430004638 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 426430004639 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 426430004640 Type II/IV secretion system protein; Region: T2SE; pfam00437 426430004641 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426430004642 Walker A motif; other site 426430004643 ATP binding site [chemical binding]; other site 426430004644 Walker B motif; other site 426430004645 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426430004646 Uncharacterized conserved protein [Function unknown]; Region: COG0011 426430004647 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 426430004648 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 426430004649 Rhomboid family; Region: Rhomboid; pfam01694 426430004650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426430004651 binding surface 426430004652 TPR motif; other site 426430004653 Tetratricopeptide repeat; Region: TPR_16; pfam13432 426430004654 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 426430004655 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 426430004656 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 426430004657 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 426430004658 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 426430004659 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 426430004660 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 426430004661 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 426430004662 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 426430004663 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 426430004664 metal binding site 2 [ion binding]; metal-binding site 426430004665 putative DNA binding helix; other site 426430004666 metal binding site 1 [ion binding]; metal-binding site 426430004667 dimer interface [polypeptide binding]; other site 426430004668 structural Zn2+ binding site [ion binding]; other site 426430004669 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 426430004670 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426430004671 ABC-ATPase subunit interface; other site 426430004672 dimer interface [polypeptide binding]; other site 426430004673 putative PBP binding regions; other site 426430004674 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 426430004675 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 426430004676 endonuclease IV; Provisional; Region: PRK01060 426430004677 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 426430004678 AP (apurinic/apyrimidinic) site pocket; other site 426430004679 DNA interaction; other site 426430004680 Metal-binding active site; metal-binding site 426430004681 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 426430004682 DEAD-like helicases superfamily; Region: DEXDc; smart00487 426430004683 ATP binding site [chemical binding]; other site 426430004684 Mg++ binding site [ion binding]; other site 426430004685 motif III; other site 426430004686 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426430004687 nucleotide binding region [chemical binding]; other site 426430004688 ATP-binding site [chemical binding]; other site 426430004689 Uncharacterized conserved protein [Function unknown]; Region: COG0327 426430004690 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 426430004691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 426430004692 Uncharacterized conserved protein [Function unknown]; Region: COG0327 426430004693 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 426430004694 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 426430004695 Family of unknown function (DUF633); Region: DUF633; pfam04816 426430004696 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 426430004697 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 426430004698 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 426430004699 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426430004700 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 426430004701 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426430004702 DNA binding residues [nucleotide binding] 426430004703 DNA primase, catalytic core; Region: dnaG; TIGR01391 426430004704 CHC2 zinc finger; Region: zf-CHC2; pfam01807 426430004705 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 426430004706 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 426430004707 active site 426430004708 metal binding site [ion binding]; metal-binding site 426430004709 interdomain interaction site; other site 426430004710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 426430004711 HTH domain; Region: HTH_11; cl17392 426430004712 FOG: CBS domain [General function prediction only]; Region: COG0517 426430004713 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 426430004714 glycyl-tRNA synthetase; Provisional; Region: PRK04173 426430004715 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426430004716 motif 1; other site 426430004717 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 426430004718 active site 426430004719 motif 2; other site 426430004720 motif 3; other site 426430004721 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 426430004722 anticodon binding site; other site 426430004723 DNA repair protein RecO; Region: reco; TIGR00613 426430004724 Recombination protein O N terminal; Region: RecO_N; pfam11967 426430004725 Recombination protein O C terminal; Region: RecO_C; pfam02565 426430004726 GTPase Era; Reviewed; Region: era; PRK00089 426430004727 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 426430004728 G1 box; other site 426430004729 GTP/Mg2+ binding site [chemical binding]; other site 426430004730 Switch I region; other site 426430004731 G2 box; other site 426430004732 Switch II region; other site 426430004733 G3 box; other site 426430004734 G4 box; other site 426430004735 G5 box; other site 426430004736 KH domain; Region: KH_2; pfam07650 426430004737 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 426430004738 active site 426430004739 catalytic motif [active] 426430004740 Zn binding site [ion binding]; other site 426430004741 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 426430004742 metal-binding heat shock protein; Provisional; Region: PRK00016 426430004743 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 426430004744 PhoH-like protein; Region: PhoH; pfam02562 426430004745 hypothetical protein; Provisional; Region: PRK13665 426430004746 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 426430004747 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 426430004748 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 426430004749 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 426430004750 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426430004751 FeS/SAM binding site; other site 426430004752 TRAM domain; Region: TRAM; cl01282 426430004753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 426430004754 RNA methyltransferase, RsmE family; Region: TIGR00046 426430004755 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 426430004756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430004757 S-adenosylmethionine binding site [chemical binding]; other site 426430004758 chaperone protein DnaJ; Provisional; Region: PRK14280 426430004759 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 426430004760 HSP70 interaction site [polypeptide binding]; other site 426430004761 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 426430004762 substrate binding site [polypeptide binding]; other site 426430004763 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 426430004764 Zn binding sites [ion binding]; other site 426430004765 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 426430004766 dimer interface [polypeptide binding]; other site 426430004767 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 426430004768 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 426430004769 nucleotide binding site [chemical binding]; other site 426430004770 NEF interaction site [polypeptide binding]; other site 426430004771 SBD interface [polypeptide binding]; other site 426430004772 heat shock protein GrpE; Provisional; Region: PRK14140 426430004773 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 426430004774 dimer interface [polypeptide binding]; other site 426430004775 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 426430004776 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 426430004777 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 426430004778 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 426430004779 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 426430004780 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426430004781 FeS/SAM binding site; other site 426430004782 HemN C-terminal domain; Region: HemN_C; pfam06969 426430004783 GTP-binding protein LepA; Provisional; Region: PRK05433 426430004784 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 426430004785 G1 box; other site 426430004786 putative GEF interaction site [polypeptide binding]; other site 426430004787 GTP/Mg2+ binding site [chemical binding]; other site 426430004788 Switch I region; other site 426430004789 G2 box; other site 426430004790 G3 box; other site 426430004791 Switch II region; other site 426430004792 G4 box; other site 426430004793 G5 box; other site 426430004794 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 426430004795 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 426430004796 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 426430004797 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 426430004798 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 426430004799 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 426430004800 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 426430004801 Competence protein; Region: Competence; pfam03772 426430004802 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 426430004803 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426430004804 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 426430004805 catalytic motif [active] 426430004806 Zn binding site [ion binding]; other site 426430004807 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 426430004808 SLBB domain; Region: SLBB; pfam10531 426430004809 Helix-hairpin-helix motif; Region: HHH; pfam00633 426430004810 Methyltransferase domain; Region: Methyltransf_31; pfam13847 426430004811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430004812 S-adenosylmethionine binding site [chemical binding]; other site 426430004813 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 426430004814 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426430004815 Zn2+ binding site [ion binding]; other site 426430004816 Mg2+ binding site [ion binding]; other site 426430004817 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 426430004818 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 426430004819 active site 426430004820 (T/H)XGH motif; other site 426430004821 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 426430004822 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 426430004823 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 426430004824 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 426430004825 shikimate binding site; other site 426430004826 NAD(P) binding site [chemical binding]; other site 426430004827 GTPase YqeH; Provisional; Region: PRK13796 426430004828 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 426430004829 GTP/Mg2+ binding site [chemical binding]; other site 426430004830 G4 box; other site 426430004831 G5 box; other site 426430004832 G1 box; other site 426430004833 Switch I region; other site 426430004834 G2 box; other site 426430004835 G3 box; other site 426430004836 Switch II region; other site 426430004837 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 426430004838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430004839 active site 426430004840 motif I; other site 426430004841 motif II; other site 426430004842 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 426430004843 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 426430004844 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 426430004845 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430004846 Fic family protein [Function unknown]; Region: COG3177 426430004847 Fic/DOC family; Region: Fic; pfam02661 426430004848 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 426430004849 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 426430004850 putative active site [active] 426430004851 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 426430004852 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 426430004853 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426430004854 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 426430004855 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 426430004856 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 426430004857 carboxyltransferase (CT) interaction site; other site 426430004858 biotinylation site [posttranslational modification]; other site 426430004859 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 426430004860 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 426430004861 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 426430004862 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 426430004863 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 426430004864 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 426430004865 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 426430004866 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 426430004867 Sugar specificity; other site 426430004868 Pyrimidine base specificity; other site 426430004869 ATP-binding site [chemical binding]; other site 426430004870 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 426430004871 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 426430004872 Peptidase family U32; Region: Peptidase_U32; pfam01136 426430004873 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 426430004874 Peptidase family U32; Region: Peptidase_U32; pfam01136 426430004875 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 426430004876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430004877 S-adenosylmethionine binding site [chemical binding]; other site 426430004878 hypothetical protein; Provisional; Region: PRK13678 426430004879 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 426430004880 hypothetical protein; Provisional; Region: PRK05473 426430004881 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 426430004882 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 426430004883 motif 1; other site 426430004884 active site 426430004885 motif 2; other site 426430004886 motif 3; other site 426430004887 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 426430004888 DHHA1 domain; Region: DHHA1; pfam02272 426430004889 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 426430004890 AAA domain; Region: AAA_30; pfam13604 426430004891 Family description; Region: UvrD_C_2; pfam13538 426430004892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426430004893 binding surface 426430004894 TPR motif; other site 426430004895 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 426430004896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426430004897 binding surface 426430004898 TPR motif; other site 426430004899 TPR repeat; Region: TPR_11; pfam13414 426430004900 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 426430004901 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 426430004902 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 426430004903 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 426430004904 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426430004905 catalytic residue [active] 426430004906 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 426430004907 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 426430004908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 426430004909 Predicted transcriptional regulator [Transcription]; Region: COG1959 426430004910 Transcriptional regulator; Region: Rrf2; pfam02082 426430004911 recombination factor protein RarA; Reviewed; Region: PRK13342 426430004912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430004913 Walker A motif; other site 426430004914 ATP binding site [chemical binding]; other site 426430004915 Walker B motif; other site 426430004916 arginine finger; other site 426430004917 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 426430004918 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 426430004919 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 426430004920 putative ATP binding site [chemical binding]; other site 426430004921 putative substrate interface [chemical binding]; other site 426430004922 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 426430004923 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 426430004924 dimer interface [polypeptide binding]; other site 426430004925 anticodon binding site; other site 426430004926 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 426430004927 homodimer interface [polypeptide binding]; other site 426430004928 motif 1; other site 426430004929 active site 426430004930 motif 2; other site 426430004931 GAD domain; Region: GAD; pfam02938 426430004932 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 426430004933 motif 3; other site 426430004934 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 426430004935 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 426430004936 dimer interface [polypeptide binding]; other site 426430004937 motif 1; other site 426430004938 active site 426430004939 motif 2; other site 426430004940 motif 3; other site 426430004941 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 426430004942 anticodon binding site; other site 426430004943 Bacterial SH3 domain homologues; Region: SH3b; smart00287 426430004944 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 426430004945 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 426430004946 active site 426430004947 metal binding site [ion binding]; metal-binding site 426430004948 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 426430004949 putative active site [active] 426430004950 dimerization interface [polypeptide binding]; other site 426430004951 putative tRNAtyr binding site [nucleotide binding]; other site 426430004952 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 426430004953 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426430004954 Zn2+ binding site [ion binding]; other site 426430004955 Mg2+ binding site [ion binding]; other site 426430004956 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 426430004957 synthetase active site [active] 426430004958 NTP binding site [chemical binding]; other site 426430004959 metal binding site [ion binding]; metal-binding site 426430004960 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 426430004961 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 426430004962 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426430004963 active site 426430004964 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 426430004965 DHH family; Region: DHH; pfam01368 426430004966 DHHA1 domain; Region: DHHA1; pfam02272 426430004967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 426430004968 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 426430004969 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 426430004970 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 426430004971 Protein export membrane protein; Region: SecD_SecF; pfam02355 426430004972 Preprotein translocase subunit; Region: YajC; pfam02699 426430004973 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 426430004974 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 426430004975 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 426430004976 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 426430004977 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 426430004978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430004979 Walker A motif; other site 426430004980 ATP binding site [chemical binding]; other site 426430004981 Walker B motif; other site 426430004982 arginine finger; other site 426430004983 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 426430004984 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 426430004985 RuvA N terminal domain; Region: RuvA_N; pfam01330 426430004986 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 426430004987 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 426430004988 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 426430004989 GTPase CgtA; Reviewed; Region: obgE; PRK12297 426430004990 GTP1/OBG; Region: GTP1_OBG; pfam01018 426430004991 Obg GTPase; Region: Obg; cd01898 426430004992 G1 box; other site 426430004993 GTP/Mg2+ binding site [chemical binding]; other site 426430004994 Switch I region; other site 426430004995 G2 box; other site 426430004996 G3 box; other site 426430004997 Switch II region; other site 426430004998 G4 box; other site 426430004999 G5 box; other site 426430005000 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 426430005001 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 426430005002 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 426430005003 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 426430005004 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 426430005005 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 426430005006 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 426430005007 rod shape-determining protein MreC; Region: MreC; pfam04085 426430005008 hypothetical protein; Reviewed; Region: PRK00024 426430005009 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 426430005010 MPN+ (JAMM) motif; other site 426430005011 Zinc-binding site [ion binding]; other site 426430005012 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 426430005013 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 426430005014 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 426430005015 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 426430005016 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426430005017 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 426430005018 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 426430005019 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426430005020 active site 426430005021 HIGH motif; other site 426430005022 nucleotide binding site [chemical binding]; other site 426430005023 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 426430005024 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 426430005025 active site 426430005026 KMSKS motif; other site 426430005027 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 426430005028 tRNA binding surface [nucleotide binding]; other site 426430005029 anticodon binding site; other site 426430005030 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 426430005031 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 426430005032 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 426430005033 Putative ammonia monooxygenase; Region: AmoA; pfam05145 426430005034 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 426430005035 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 426430005036 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426430005037 inhibitor-cofactor binding pocket; inhibition site 426430005038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430005039 catalytic residue [active] 426430005040 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 426430005041 dimer interface [polypeptide binding]; other site 426430005042 active site 426430005043 Schiff base residues; other site 426430005044 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 426430005045 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 426430005046 active site 426430005047 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 426430005048 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 426430005049 domain interfaces; other site 426430005050 active site 426430005051 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 426430005052 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 426430005053 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 426430005054 tRNA; other site 426430005055 putative tRNA binding site [nucleotide binding]; other site 426430005056 putative NADP binding site [chemical binding]; other site 426430005057 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 426430005058 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 426430005059 G1 box; other site 426430005060 GTP/Mg2+ binding site [chemical binding]; other site 426430005061 Switch I region; other site 426430005062 G2 box; other site 426430005063 G3 box; other site 426430005064 Switch II region; other site 426430005065 G4 box; other site 426430005066 G5 box; other site 426430005067 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 426430005068 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 426430005069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430005070 Walker A motif; other site 426430005071 ATP binding site [chemical binding]; other site 426430005072 Walker B motif; other site 426430005073 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 426430005074 trigger factor; Provisional; Region: tig; PRK01490 426430005075 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 426430005076 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 426430005077 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 426430005078 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 426430005079 23S rRNA binding site [nucleotide binding]; other site 426430005080 L21 binding site [polypeptide binding]; other site 426430005081 L13 binding site [polypeptide binding]; other site 426430005082 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 426430005083 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 426430005084 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 426430005085 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 426430005086 lysine transporter; Provisional; Region: PRK10836 426430005087 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 426430005088 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 426430005089 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 426430005090 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 426430005091 active site 426430005092 dimer interface [polypeptide binding]; other site 426430005093 motif 1; other site 426430005094 motif 2; other site 426430005095 motif 3; other site 426430005096 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 426430005097 anticodon binding site; other site 426430005098 primosomal protein DnaI; Reviewed; Region: PRK08939 426430005099 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 426430005100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430005101 Walker A motif; other site 426430005102 ATP binding site [chemical binding]; other site 426430005103 Walker B motif; other site 426430005104 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 426430005105 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 426430005106 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 426430005107 ATP cone domain; Region: ATP-cone; pfam03477 426430005108 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 426430005109 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 426430005110 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 426430005111 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 426430005112 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 426430005113 CoA-binding site [chemical binding]; other site 426430005114 ATP-binding [chemical binding]; other site 426430005115 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 426430005116 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 426430005117 DNA binding site [nucleotide binding] 426430005118 catalytic residue [active] 426430005119 H2TH interface [polypeptide binding]; other site 426430005120 putative catalytic residues [active] 426430005121 turnover-facilitating residue; other site 426430005122 intercalation triad [nucleotide binding]; other site 426430005123 8OG recognition residue [nucleotide binding]; other site 426430005124 putative reading head residues; other site 426430005125 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 426430005126 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 426430005127 DNA polymerase I; Provisional; Region: PRK05755 426430005128 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 426430005129 active site 426430005130 metal binding site 1 [ion binding]; metal-binding site 426430005131 putative 5' ssDNA interaction site; other site 426430005132 metal binding site 3; metal-binding site 426430005133 metal binding site 2 [ion binding]; metal-binding site 426430005134 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 426430005135 putative DNA binding site [nucleotide binding]; other site 426430005136 putative metal binding site [ion binding]; other site 426430005137 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 426430005138 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 426430005139 active site 426430005140 DNA binding site [nucleotide binding] 426430005141 catalytic site [active] 426430005142 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 426430005143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426430005144 dimer interface [polypeptide binding]; other site 426430005145 phosphorylation site [posttranslational modification] 426430005146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430005147 ATP binding site [chemical binding]; other site 426430005148 Mg2+ binding site [ion binding]; other site 426430005149 G-X-G motif; other site 426430005150 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426430005151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430005152 active site 426430005153 phosphorylation site [posttranslational modification] 426430005154 intermolecular recognition site; other site 426430005155 dimerization interface [polypeptide binding]; other site 426430005156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426430005157 DNA binding site [nucleotide binding] 426430005158 isocitrate dehydrogenase; Reviewed; Region: PRK07006 426430005159 isocitrate dehydrogenase; Validated; Region: PRK07362 426430005160 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 426430005161 dimer interface [polypeptide binding]; other site 426430005162 Citrate synthase; Region: Citrate_synt; pfam00285 426430005163 active site 426430005164 citrylCoA binding site [chemical binding]; other site 426430005165 oxalacetate/citrate binding site [chemical binding]; other site 426430005166 coenzyme A binding site [chemical binding]; other site 426430005167 catalytic triad [active] 426430005168 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 426430005169 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 426430005170 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 426430005171 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 426430005172 pyruvate kinase; Provisional; Region: PRK06354 426430005173 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 426430005174 domain interfaces; other site 426430005175 active site 426430005176 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 426430005177 6-phosphofructokinase; Provisional; Region: PRK03202 426430005178 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 426430005179 active site 426430005180 ADP/pyrophosphate binding site [chemical binding]; other site 426430005181 dimerization interface [polypeptide binding]; other site 426430005182 allosteric effector site; other site 426430005183 fructose-1,6-bisphosphate binding site; other site 426430005184 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 426430005185 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 426430005186 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 426430005187 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 426430005188 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 426430005189 Malic enzyme, N-terminal domain; Region: malic; pfam00390 426430005190 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 426430005191 putative NAD(P) binding site [chemical binding]; other site 426430005192 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 426430005193 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 426430005194 active site 426430005195 PHP Thumb interface [polypeptide binding]; other site 426430005196 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 426430005197 generic binding surface I; other site 426430005198 generic binding surface II; other site 426430005199 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 426430005200 DHH family; Region: DHH; pfam01368 426430005201 DHHA1 domain; Region: DHHA1; pfam02272 426430005202 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 426430005203 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 426430005204 DNA-binding site [nucleotide binding]; DNA binding site 426430005205 DRTGG domain; Region: DRTGG; pfam07085 426430005206 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 426430005207 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 426430005208 active site 2 [active] 426430005209 active site 1 [active] 426430005210 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426430005211 Ligand Binding Site [chemical binding]; other site 426430005212 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 426430005213 metal-dependent hydrolase; Provisional; Region: PRK00685 426430005214 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 426430005215 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 426430005216 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 426430005217 active site 426430005218 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 426430005219 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 426430005220 hexamer interface [polypeptide binding]; other site 426430005221 ligand binding site [chemical binding]; other site 426430005222 putative active site [active] 426430005223 NAD(P) binding site [chemical binding]; other site 426430005224 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426430005225 Ligand Binding Site [chemical binding]; other site 426430005226 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 426430005227 propionate/acetate kinase; Provisional; Region: PRK12379 426430005228 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 426430005229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430005230 S-adenosylmethionine binding site [chemical binding]; other site 426430005231 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 426430005232 dimer interface [polypeptide binding]; other site 426430005233 catalytic triad [active] 426430005234 peroxidatic and resolving cysteines [active] 426430005235 hypothetical protein; Provisional; Region: PRK10621 426430005236 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 426430005237 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 426430005238 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 426430005239 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 426430005240 Ligand Binding Site [chemical binding]; other site 426430005241 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 426430005242 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 426430005243 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426430005244 catalytic residue [active] 426430005245 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 426430005246 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 426430005247 GAF domain; Region: GAF_2; pfam13185 426430005248 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 426430005249 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 426430005250 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426430005251 RNA binding surface [nucleotide binding]; other site 426430005252 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 426430005253 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 426430005254 active site 426430005255 catalytic site [active] 426430005256 OsmC-like protein; Region: OsmC; cl00767 426430005257 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 426430005258 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426430005259 catalytic residue [active] 426430005260 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 426430005261 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 426430005262 ligand binding site [chemical binding]; other site 426430005263 NAD binding site [chemical binding]; other site 426430005264 dimerization interface [polypeptide binding]; other site 426430005265 catalytic site [active] 426430005266 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 426430005267 putative L-serine binding site [chemical binding]; other site 426430005268 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 426430005269 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430005270 motif II; other site 426430005271 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 426430005272 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 426430005273 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 426430005274 active site turn [active] 426430005275 phosphorylation site [posttranslational modification] 426430005276 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 426430005277 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 426430005278 putative acyl-acceptor binding pocket; other site 426430005279 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426430005280 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426430005281 protein binding site [polypeptide binding]; other site 426430005282 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 426430005283 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 426430005284 active site 426430005285 HIGH motif; other site 426430005286 dimer interface [polypeptide binding]; other site 426430005287 KMSKS motif; other site 426430005288 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426430005289 RNA binding surface [nucleotide binding]; other site 426430005290 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 426430005291 Transglycosylase; Region: Transgly; pfam00912 426430005292 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 426430005293 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 426430005294 NEAr Transporter domain; Region: NEAT; smart00725 426430005295 NEAr Transporter domain; Region: NEAT; smart00725 426430005296 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 426430005297 heme-binding site [chemical binding]; other site 426430005298 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 426430005299 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 426430005300 Potassium binding sites [ion binding]; other site 426430005301 Cesium cation binding sites [ion binding]; other site 426430005302 acetyl-CoA synthetase; Provisional; Region: PRK04319 426430005303 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 426430005304 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 426430005305 active site 426430005306 acyl-activating enzyme (AAE) consensus motif; other site 426430005307 putative CoA binding site [chemical binding]; other site 426430005308 AMP binding site [chemical binding]; other site 426430005309 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 426430005310 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 426430005311 active site 426430005312 Zn binding site [ion binding]; other site 426430005313 catabolite control protein A; Region: ccpA; TIGR01481 426430005314 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 426430005315 DNA binding site [nucleotide binding] 426430005316 domain linker motif; other site 426430005317 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 426430005318 dimerization interface [polypeptide binding]; other site 426430005319 effector binding site; other site 426430005320 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 426430005321 Chorismate mutase type II; Region: CM_2; cl00693 426430005322 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 426430005323 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 426430005324 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 426430005325 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 426430005326 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426430005327 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 426430005328 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 426430005329 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 426430005330 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 426430005331 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 426430005332 putative tRNA-binding site [nucleotide binding]; other site 426430005333 hypothetical protein; Provisional; Region: PRK13668 426430005334 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 426430005335 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 426430005336 catalytic residues [active] 426430005337 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 426430005338 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 426430005339 oligomer interface [polypeptide binding]; other site 426430005340 active site 426430005341 metal binding site [ion binding]; metal-binding site 426430005342 Predicted small secreted protein [Function unknown]; Region: COG5584 426430005343 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 426430005344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430005345 S-adenosylmethionine binding site [chemical binding]; other site 426430005346 Phosphotransferase enzyme family; Region: APH; pfam01636 426430005347 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 426430005348 active site 426430005349 substrate binding site [chemical binding]; other site 426430005350 ATP binding site [chemical binding]; other site 426430005351 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 426430005352 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 426430005353 homodimer interface [polypeptide binding]; other site 426430005354 substrate-cofactor binding pocket; other site 426430005355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430005356 catalytic residue [active] 426430005357 dipeptidase PepV; Reviewed; Region: PRK07318 426430005358 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 426430005359 active site 426430005360 metal binding site [ion binding]; metal-binding site 426430005361 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 426430005362 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426430005363 RNA binding surface [nucleotide binding]; other site 426430005364 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 426430005365 active site 426430005366 uracil binding [chemical binding]; other site 426430005367 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 426430005368 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 426430005369 HI0933-like protein; Region: HI0933_like; pfam03486 426430005370 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 426430005371 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 426430005372 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005373 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005374 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005375 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005376 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005377 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005378 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005379 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005380 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005381 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005382 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005383 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005384 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005385 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005386 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430005387 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 426430005388 active site residue [active] 426430005389 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 426430005390 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 426430005391 HIGH motif; other site 426430005392 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 426430005393 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 426430005394 active site 426430005395 KMSKS motif; other site 426430005396 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 426430005397 tRNA binding surface [nucleotide binding]; other site 426430005398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430005399 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426430005400 putative substrate translocation pore; other site 426430005401 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 426430005402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430005403 S-adenosylmethionine binding site [chemical binding]; other site 426430005404 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 426430005405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 426430005406 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 426430005407 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426430005408 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 426430005409 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 426430005410 homopentamer interface [polypeptide binding]; other site 426430005411 active site 426430005412 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 426430005413 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 426430005414 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 426430005415 dimerization interface [polypeptide binding]; other site 426430005416 active site 426430005417 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 426430005418 Lumazine binding domain; Region: Lum_binding; pfam00677 426430005419 Lumazine binding domain; Region: Lum_binding; pfam00677 426430005420 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 426430005421 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 426430005422 catalytic motif [active] 426430005423 Zn binding site [ion binding]; other site 426430005424 RibD C-terminal domain; Region: RibD_C; cl17279 426430005425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 426430005426 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 426430005427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426430005428 dimerization interface [polypeptide binding]; other site 426430005429 putative DNA binding site [nucleotide binding]; other site 426430005430 putative Zn2+ binding site [ion binding]; other site 426430005431 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 426430005432 arsenical pump membrane protein; Provisional; Region: PRK15445 426430005433 transmembrane helices; other site 426430005434 Low molecular weight phosphatase family; Region: LMWPc; cd00115 426430005435 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 426430005436 active site 426430005437 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 426430005438 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 426430005439 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 426430005440 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 426430005441 DNA binding residues [nucleotide binding] 426430005442 CAAX protease self-immunity; Region: Abi; pfam02517 426430005443 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 426430005444 active site 426430005445 intersubunit interactions; other site 426430005446 catalytic residue [active] 426430005447 camphor resistance protein CrcB; Provisional; Region: PRK14201 426430005448 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 426430005449 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 426430005450 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 426430005451 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 426430005452 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426430005453 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426430005454 active site 426430005455 catalytic tetrad [active] 426430005456 S-adenosylmethionine synthetase; Validated; Region: PRK05250 426430005457 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 426430005458 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 426430005459 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 426430005460 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 426430005461 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 426430005462 active site 426430005463 substrate-binding site [chemical binding]; other site 426430005464 metal-binding site [ion binding] 426430005465 ATP binding site [chemical binding]; other site 426430005466 Transposase IS200 like; Region: Y1_Tnp; pfam01797 426430005467 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 426430005468 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426430005469 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 426430005470 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 426430005471 nudix motif; other site 426430005472 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 426430005473 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 426430005474 metal binding site [ion binding]; metal-binding site 426430005475 substrate binding pocket [chemical binding]; other site 426430005476 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 426430005477 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 426430005478 acyl-activating enzyme (AAE) consensus motif; other site 426430005479 putative AMP binding site [chemical binding]; other site 426430005480 putative active site [active] 426430005481 putative CoA binding site [chemical binding]; other site 426430005482 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 426430005483 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 426430005484 Domain of unknown function (DUF955); Region: DUF955; pfam06114 426430005485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 426430005486 Transposase; Region: HTH_Tnp_1; cl17663 426430005487 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 426430005488 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 426430005489 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 426430005490 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 426430005491 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 426430005492 HsdM N-terminal domain; Region: HsdM_N; pfam12161 426430005493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430005494 S-adenosylmethionine binding site [chemical binding]; other site 426430005495 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 426430005496 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 426430005497 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 426430005498 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 426430005499 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 426430005500 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 426430005501 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 426430005502 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 426430005503 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 426430005504 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 426430005505 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 426430005506 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 426430005507 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 426430005508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426430005509 Walker A/P-loop; other site 426430005510 ATP binding site [chemical binding]; other site 426430005511 Q-loop/lid; other site 426430005512 ABC transporter signature motif; other site 426430005513 Walker B; other site 426430005514 D-loop; other site 426430005515 H-loop/switch region; other site 426430005516 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 426430005517 active site 426430005518 catalytic triad [active] 426430005519 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 426430005520 Flavoprotein; Region: Flavoprotein; pfam02441 426430005521 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 426430005522 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 426430005523 active site 426430005524 zinc binding site [ion binding]; other site 426430005525 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 426430005526 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 426430005527 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 426430005528 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 426430005529 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 426430005530 beta-channel forming cytolysin; Region: hlyII; TIGR01002 426430005531 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 426430005532 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 426430005533 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 426430005534 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 426430005535 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 426430005536 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 426430005537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426430005538 ferrochelatase; Provisional; Region: PRK12435 426430005539 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 426430005540 C-terminal domain interface [polypeptide binding]; other site 426430005541 active site 426430005542 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 426430005543 active site 426430005544 N-terminal domain interface [polypeptide binding]; other site 426430005545 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 426430005546 substrate binding site [chemical binding]; other site 426430005547 active site 426430005548 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 426430005549 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 426430005550 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 426430005551 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 426430005552 Walker A/P-loop; other site 426430005553 ATP binding site [chemical binding]; other site 426430005554 Q-loop/lid; other site 426430005555 ABC transporter signature motif; other site 426430005556 Walker B; other site 426430005557 D-loop; other site 426430005558 H-loop/switch region; other site 426430005559 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 426430005560 HIT family signature motif; other site 426430005561 catalytic residue [active] 426430005562 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 426430005563 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 426430005564 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 426430005565 SurA N-terminal domain; Region: SurA_N_3; cl07813 426430005566 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 426430005567 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 426430005568 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 426430005569 generic binding surface II; other site 426430005570 generic binding surface I; other site 426430005571 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426430005572 Zn2+ binding site [ion binding]; other site 426430005573 Mg2+ binding site [ion binding]; other site 426430005574 Uncharacterized conserved protein [Function unknown]; Region: COG4717 426430005575 P-loop containing region of AAA domain; Region: AAA_29; cl17516 426430005576 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 426430005577 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 426430005578 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 426430005579 active site 426430005580 metal binding site [ion binding]; metal-binding site 426430005581 DNA binding site [nucleotide binding] 426430005582 hypothetical protein; Provisional; Region: PRK13676 426430005583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 426430005584 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426430005585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426430005586 non-specific DNA binding site [nucleotide binding]; other site 426430005587 salt bridge; other site 426430005588 sequence-specific DNA binding site [nucleotide binding]; other site 426430005589 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426430005590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430005591 active site 426430005592 phosphorylation site [posttranslational modification] 426430005593 intermolecular recognition site; other site 426430005594 dimerization interface [polypeptide binding]; other site 426430005595 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426430005596 DNA binding residues [nucleotide binding] 426430005597 dimerization interface [polypeptide binding]; other site 426430005598 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426430005599 GAF domain; Region: GAF_3; pfam13492 426430005600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 426430005601 Histidine kinase; Region: HisKA_3; pfam07730 426430005602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430005603 ATP binding site [chemical binding]; other site 426430005604 Mg2+ binding site [ion binding]; other site 426430005605 G-X-G motif; other site 426430005606 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 426430005607 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 426430005608 active site 426430005609 fumarate hydratase; Reviewed; Region: fumC; PRK00485 426430005610 Class II fumarases; Region: Fumarase_classII; cd01362 426430005611 active site 426430005612 tetramer interface [polypeptide binding]; other site 426430005613 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 426430005614 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 426430005615 active site 426430005616 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 426430005617 epoxyqueuosine reductase; Region: TIGR00276 426430005618 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 426430005619 HEAT repeats; Region: HEAT_2; pfam13646 426430005620 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426430005621 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426430005622 Walker A/P-loop; other site 426430005623 ATP binding site [chemical binding]; other site 426430005624 Q-loop/lid; other site 426430005625 ABC transporter signature motif; other site 426430005626 Walker B; other site 426430005627 D-loop; other site 426430005628 H-loop/switch region; other site 426430005629 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426430005630 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426430005631 substrate binding pocket [chemical binding]; other site 426430005632 membrane-bound complex binding site; other site 426430005633 hinge residues; other site 426430005634 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426430005635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430005636 dimer interface [polypeptide binding]; other site 426430005637 conserved gate region; other site 426430005638 putative PBP binding loops; other site 426430005639 ABC-ATPase subunit interface; other site 426430005640 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 426430005641 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 426430005642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 426430005643 Transposase; Region: DDE_Tnp_ISL3; pfam01610 426430005644 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 426430005645 metal binding site 2 [ion binding]; metal-binding site 426430005646 putative DNA binding helix; other site 426430005647 metal binding site 1 [ion binding]; metal-binding site 426430005648 dimer interface [polypeptide binding]; other site 426430005649 structural Zn2+ binding site [ion binding]; other site 426430005650 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 426430005651 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 426430005652 putative ligand binding site [chemical binding]; other site 426430005653 NAD binding site [chemical binding]; other site 426430005654 catalytic site [active] 426430005655 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 426430005656 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 426430005657 catalytic triad [active] 426430005658 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 426430005659 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426430005660 inhibitor-cofactor binding pocket; inhibition site 426430005661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430005662 catalytic residue [active] 426430005663 Predicted membrane protein [Function unknown]; Region: COG4129 426430005664 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 426430005665 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426430005666 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426430005667 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 426430005668 Walker A/P-loop; other site 426430005669 ATP binding site [chemical binding]; other site 426430005670 Q-loop/lid; other site 426430005671 ABC transporter signature motif; other site 426430005672 Walker B; other site 426430005673 D-loop; other site 426430005674 H-loop/switch region; other site 426430005675 hypothetical protein; Provisional; Region: PRK13662 426430005676 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 426430005677 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 426430005678 minor groove reading motif; other site 426430005679 helix-hairpin-helix signature motif; other site 426430005680 substrate binding pocket [chemical binding]; other site 426430005681 active site 426430005682 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 426430005683 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 426430005684 DNA binding and oxoG recognition site [nucleotide binding] 426430005685 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 426430005686 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 426430005687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426430005688 Walker A/P-loop; other site 426430005689 ATP binding site [chemical binding]; other site 426430005690 Q-loop/lid; other site 426430005691 ABC transporter signature motif; other site 426430005692 Walker B; other site 426430005693 H-loop/switch region; other site 426430005694 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 426430005695 recombination regulator RecX; Provisional; Region: recX; PRK14135 426430005696 glycosyltransferase; Provisional; Region: PRK13481 426430005697 Transglycosylase; Region: Transgly; pfam00912 426430005698 intracellular protease, PfpI family; Region: PfpI; TIGR01382 426430005699 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 426430005700 proposed catalytic triad [active] 426430005701 conserved cys residue [active] 426430005702 CHAP domain; Region: CHAP; pfam05257 426430005703 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 426430005704 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 426430005705 active site 426430005706 metal binding site [ion binding]; metal-binding site 426430005707 Bacterial SH3 domain; Region: SH3_5; pfam08460 426430005708 holin, SPP1 family; Region: holin_SPP1; TIGR01592 426430005709 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 426430005710 CHAP domain; Region: CHAP; pfam05257 426430005711 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 426430005712 Lysozyme subfamily 2; Region: LYZ2; smart00047 426430005713 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 426430005714 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 426430005715 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 426430005716 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 426430005717 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 426430005718 active site 426430005719 catalytic triad [active] 426430005720 oxyanion hole [active] 426430005721 Phage tail protein; Region: Sipho_tail; pfam05709 426430005722 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 426430005723 Phage-related protein [Function unknown]; Region: COG5412 426430005724 membrane protein P6; Region: PHA01399 426430005725 Phage protein; Region: DUF3647; pfam12363 426430005726 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 426430005727 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 426430005728 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 426430005729 Phage capsid family; Region: Phage_capsid; pfam05065 426430005730 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 426430005731 phage putative head morphogenesis protein, SPP1 gp7 family; Region: phageSPP1_gp7; TIGR01641 426430005732 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 426430005733 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 426430005734 phage terminase, large subunit, PBSX family; Region: phage_term_2; TIGR01547 426430005735 Terminase small subunit; Region: Terminase_2; pfam03592 426430005736 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 426430005737 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 426430005738 dUTPase; Region: dUTPase_2; pfam08761 426430005739 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 426430005740 active site 426430005741 homodimer interface [polypeptide binding]; other site 426430005742 metal binding site [ion binding]; metal-binding site 426430005743 YopX protein; Region: YopX; pfam09643 426430005744 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 426430005745 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 426430005746 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 426430005747 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 426430005748 hypothetical protein; Validated; Region: PRK08116 426430005749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430005750 Walker A motif; other site 426430005751 ATP binding site [chemical binding]; other site 426430005752 Walker B motif; other site 426430005753 Helix-turn-helix domain; Region: HTH_36; pfam13730 426430005754 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 426430005755 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 426430005756 Protein of unknown function (DUF968); Region: DUF968; pfam06147 426430005757 AAA domain; Region: AAA_24; pfam13479 426430005758 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 426430005759 Phage anti-repressor protein [Transcription]; Region: COG3561 426430005760 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 426430005761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426430005762 non-specific DNA binding site [nucleotide binding]; other site 426430005763 salt bridge; other site 426430005764 sequence-specific DNA binding site [nucleotide binding]; other site 426430005765 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 426430005766 Catalytic site [active] 426430005767 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 426430005768 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 426430005769 Int/Topo IB signature motif; other site 426430005770 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 426430005771 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426430005772 FeS/SAM binding site; other site 426430005773 YfkB-like domain; Region: YfkB; pfam08756 426430005774 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 426430005775 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 426430005776 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 426430005777 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 426430005778 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 426430005779 Low molecular weight phosphatase family; Region: LMWPc; cd00115 426430005780 active site 426430005781 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 426430005782 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426430005783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430005784 active site 426430005785 phosphorylation site [posttranslational modification] 426430005786 intermolecular recognition site; other site 426430005787 dimerization interface [polypeptide binding]; other site 426430005788 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426430005789 DNA binding residues [nucleotide binding] 426430005790 dimerization interface [polypeptide binding]; other site 426430005791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 426430005792 Histidine kinase; Region: HisKA_3; pfam07730 426430005793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430005794 ATP binding site [chemical binding]; other site 426430005795 Mg2+ binding site [ion binding]; other site 426430005796 G-X-G motif; other site 426430005797 Predicted membrane protein [Function unknown]; Region: COG4758 426430005798 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 426430005799 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 426430005800 active site 426430005801 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 426430005802 catalytic triad [active] 426430005803 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 426430005804 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426430005805 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 426430005806 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 426430005807 Ferritin-like domain; Region: Ferritin; pfam00210 426430005808 ferroxidase diiron center [ion binding]; other site 426430005809 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 426430005810 active site 426430005811 catalytic site [active] 426430005812 substrate binding site [chemical binding]; other site 426430005813 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 426430005814 active site 426430005815 DNA polymerase IV; Validated; Region: PRK02406 426430005816 DNA binding site [nucleotide binding] 426430005817 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 426430005818 TRAM domain; Region: TRAM; cl01282 426430005819 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 426430005820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430005821 S-adenosylmethionine binding site [chemical binding]; other site 426430005822 putative lipid kinase; Reviewed; Region: PRK13337 426430005823 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 426430005824 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 426430005825 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 426430005826 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 426430005827 GatB domain; Region: GatB_Yqey; pfam02637 426430005828 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 426430005829 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 426430005830 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 426430005831 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 426430005832 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 426430005833 Na binding site [ion binding]; other site 426430005834 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 426430005835 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 426430005836 putative dimer interface [polypeptide binding]; other site 426430005837 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 426430005838 putative dimer interface [polypeptide binding]; other site 426430005839 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 426430005840 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 426430005841 nucleotide binding pocket [chemical binding]; other site 426430005842 K-X-D-G motif; other site 426430005843 catalytic site [active] 426430005844 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 426430005845 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 426430005846 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 426430005847 Dimer interface [polypeptide binding]; other site 426430005848 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 426430005849 Part of AAA domain; Region: AAA_19; pfam13245 426430005850 Family description; Region: UvrD_C_2; pfam13538 426430005851 PcrB family; Region: PcrB; pfam01884 426430005852 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 426430005853 substrate binding site [chemical binding]; other site 426430005854 putative active site [active] 426430005855 dimer interface [polypeptide binding]; other site 426430005856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 426430005857 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 426430005858 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 426430005859 tetramer interface [polypeptide binding]; other site 426430005860 active site 426430005861 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 426430005862 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 426430005863 Staphostatin A; Region: Staphostatin_A; pfam09022 426430005864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 426430005865 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 426430005866 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 426430005867 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 426430005868 homodimer interface [polypeptide binding]; other site 426430005869 NAD binding pocket [chemical binding]; other site 426430005870 ATP binding pocket [chemical binding]; other site 426430005871 Mg binding site [ion binding]; other site 426430005872 active-site loop [active] 426430005873 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 426430005874 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 426430005875 active site 426430005876 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 426430005877 active site 426430005878 dimer interface [polypeptide binding]; other site 426430005879 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 426430005880 Prephenate dehydratase; Region: PDT; pfam00800 426430005881 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 426430005882 putative L-Phe binding site [chemical binding]; other site 426430005883 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 426430005884 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 426430005885 transmembrane helices; other site 426430005886 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 426430005887 Isochorismatase family; Region: Isochorismatase; pfam00857 426430005888 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 426430005889 catalytic triad [active] 426430005890 conserved cis-peptide bond; other site 426430005891 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 426430005892 DHH family; Region: DHH; pfam01368 426430005893 DHHA2 domain; Region: DHHA2; pfam02833 426430005894 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 426430005895 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 426430005896 NAD(P) binding site [chemical binding]; other site 426430005897 catalytic residues [active] 426430005898 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 426430005899 YolD-like protein; Region: YolD; pfam08863 426430005900 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 426430005901 active site 426430005902 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 426430005903 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 426430005904 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 426430005905 Bacterial PH domain; Region: DUF304; cl01348 426430005906 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 426430005907 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 426430005908 Walker A/P-loop; other site 426430005909 ATP binding site [chemical binding]; other site 426430005910 Q-loop/lid; other site 426430005911 ABC transporter signature motif; other site 426430005912 Walker B; other site 426430005913 D-loop; other site 426430005914 H-loop/switch region; other site 426430005915 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 426430005916 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 426430005917 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 426430005918 Walker A/P-loop; other site 426430005919 ATP binding site [chemical binding]; other site 426430005920 Q-loop/lid; other site 426430005921 ABC transporter signature motif; other site 426430005922 Walker B; other site 426430005923 D-loop; other site 426430005924 H-loop/switch region; other site 426430005925 Predicted transcriptional regulators [Transcription]; Region: COG1725 426430005926 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426430005927 DNA-binding site [nucleotide binding]; DNA binding site 426430005928 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 426430005929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426430005930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430005931 homodimer interface [polypeptide binding]; other site 426430005932 catalytic residue [active] 426430005933 MAP domain; Region: MAP; pfam03642 426430005934 MAP domain; Region: MAP; pfam03642 426430005935 MAP domain; Region: MAP; pfam03642 426430005936 MAP domain; Region: MAP; pfam03642 426430005937 MAP domain; Region: MAP; pfam03642 426430005938 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 426430005939 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 426430005940 chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032 426430005941 Bacterial SH3 domain homologues; Region: SH3b; smart00287 426430005942 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 426430005943 CHAP domain; Region: CHAP; pfam05257 426430005944 Small integral membrane protein [Function unknown]; Region: COG5546 426430005945 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 426430005946 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 426430005947 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 426430005948 Ligand-gated ion channel; Region: Lig_chan; pfam00060 426430005949 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 426430005950 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 426430005951 Phage tail protein; Region: Sipho_tail; cl17486 426430005952 Phage tail protein; Region: Sipho_tail; cl17486 426430005953 Phage-related minor tail protein [Function unknown]; Region: COG5280 426430005954 Phage-related protein [Function unknown]; Region: COG5412 426430005955 Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606 426430005956 Peptidase family M23; Region: Peptidase_M23; pfam01551 426430005957 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 426430005958 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426430005959 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426430005960 catalytic residue [active] 426430005961 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 426430005962 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 426430005963 Translocation protein Sec62; Region: Sec62; cl02170 426430005964 Phage capsid family; Region: Phage_capsid; pfam05065 426430005965 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 426430005966 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 426430005967 oligomer interface [polypeptide binding]; other site 426430005968 active site residues [active] 426430005969 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 426430005970 Phage-related protein [Function unknown]; Region: COG4695; cl01923 426430005971 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 426430005972 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 426430005973 HNH endonuclease; Region: HNH; pfam01844 426430005974 active site 426430005975 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 426430005976 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 426430005977 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 426430005978 trimer interface [polypeptide binding]; other site 426430005979 active site 426430005980 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 426430005981 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 426430005982 Endodeoxyribonuclease RusA; Region: RusA; cl01885 426430005983 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 426430005984 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 426430005985 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 426430005986 dimer interface [polypeptide binding]; other site 426430005987 ssDNA binding site [nucleotide binding]; other site 426430005988 tetramer (dimer of dimers) interface [polypeptide binding]; other site 426430005989 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 426430005990 RecT family; Region: RecT; pfam03837 426430005991 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 426430005992 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 426430005993 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 426430005994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 426430005995 Phage anti-repressor protein [Transcription]; Region: COG3561 426430005996 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 426430005997 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 426430005998 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426430005999 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426430006000 non-specific DNA binding site [nucleotide binding]; other site 426430006001 salt bridge; other site 426430006002 sequence-specific DNA binding site [nucleotide binding]; other site 426430006003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426430006004 non-specific DNA binding site [nucleotide binding]; other site 426430006005 salt bridge; other site 426430006006 sequence-specific DNA binding site [nucleotide binding]; other site 426430006007 Predicted transcriptional regulator [Transcription]; Region: COG2932 426430006008 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 426430006009 Catalytic site [active] 426430006010 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 426430006011 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 426430006012 active site 426430006013 catalytic site [active] 426430006014 substrate binding site [chemical binding]; other site 426430006015 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 426430006016 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 426430006017 Int/Topo IB signature motif; other site 426430006018 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 426430006019 putative catalytic site [active] 426430006020 phosphate binding site [ion binding]; other site 426430006021 metal binding site A [ion binding]; metal-binding site 426430006022 metal binding site C [ion binding]; metal-binding site 426430006023 metal binding site B [ion binding]; metal-binding site 426430006024 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 426430006025 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 426430006026 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 426430006027 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 426430006028 metal binding site [ion binding]; metal-binding site 426430006029 dimer interface [polypeptide binding]; other site 426430006030 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 426430006031 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 426430006032 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 426430006033 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 426430006034 putative ligand binding residues [chemical binding]; other site 426430006035 Cation transport protein; Region: TrkH; cl17365 426430006036 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 426430006037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430006038 Coenzyme A binding pocket [chemical binding]; other site 426430006039 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 426430006040 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426430006041 Int/Topo IB signature motif; other site 426430006042 DNA binding site [nucleotide binding] 426430006043 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 426430006044 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 426430006045 ring oligomerisation interface [polypeptide binding]; other site 426430006046 ATP/Mg binding site [chemical binding]; other site 426430006047 stacking interactions; other site 426430006048 hinge regions; other site 426430006049 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 426430006050 oligomerisation interface [polypeptide binding]; other site 426430006051 mobile loop; other site 426430006052 roof hairpin; other site 426430006053 CAAX protease self-immunity; Region: Abi; pfam02517 426430006054 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 426430006055 dimer interface [polypeptide binding]; other site 426430006056 FMN binding site [chemical binding]; other site 426430006057 Predicted amidohydrolase [General function prediction only]; Region: COG0388 426430006058 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 426430006059 putative active site [active] 426430006060 catalytic triad [active] 426430006061 putative dimer interface [polypeptide binding]; other site 426430006062 Accessory gene regulator B; Region: AgrB; smart00793 426430006063 Staphylococcal AgrD protein; Region: AgrD; smart00794 426430006064 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 426430006065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430006066 Mg2+ binding site [ion binding]; other site 426430006067 G-X-G motif; other site 426430006068 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 426430006069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430006070 active site 426430006071 phosphorylation site [posttranslational modification] 426430006072 intermolecular recognition site; other site 426430006073 dimerization interface [polypeptide binding]; other site 426430006074 LytTr DNA-binding domain; Region: LytTR; pfam04397 426430006075 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 426430006076 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 426430006077 putative substrate binding site [chemical binding]; other site 426430006078 putative ATP binding site [chemical binding]; other site 426430006079 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 426430006080 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 426430006081 substrate binding [chemical binding]; other site 426430006082 active site 426430006083 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 426430006084 Transcriptional regulators [Transcription]; Region: PurR; COG1609 426430006085 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 426430006086 DNA binding site [nucleotide binding] 426430006087 domain linker motif; other site 426430006088 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 426430006089 dimerization interface [polypeptide binding]; other site 426430006090 ligand binding site [chemical binding]; other site 426430006091 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 426430006092 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 426430006093 CPxP motif; other site 426430006094 Predicted transporter component [General function prediction only]; Region: COG2391 426430006095 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 426430006096 Sulphur transport; Region: Sulf_transp; pfam04143 426430006097 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 426430006098 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 426430006099 CoA binding domain; Region: CoA_binding; pfam02629 426430006100 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 426430006101 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426430006102 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426430006103 ABC transporter; Region: ABC_tran_2; pfam12848 426430006104 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426430006105 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 426430006106 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 426430006107 Walker A/P-loop; other site 426430006108 ATP binding site [chemical binding]; other site 426430006109 Q-loop/lid; other site 426430006110 ABC transporter signature motif; other site 426430006111 Walker B; other site 426430006112 D-loop; other site 426430006113 H-loop/switch region; other site 426430006114 UGMP family protein; Validated; Region: PRK09604 426430006115 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 426430006116 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 426430006117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430006118 Coenzyme A binding pocket [chemical binding]; other site 426430006119 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 426430006120 Glycoprotease family; Region: Peptidase_M22; pfam00814 426430006121 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 426430006122 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 426430006123 6-phosphogluconate dehydratase; Region: edd; TIGR01196 426430006124 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 426430006125 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426430006126 PYR/PP interface [polypeptide binding]; other site 426430006127 dimer interface [polypeptide binding]; other site 426430006128 TPP binding site [chemical binding]; other site 426430006129 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426430006130 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 426430006131 TPP-binding site [chemical binding]; other site 426430006132 dimer interface [polypeptide binding]; other site 426430006133 ketol-acid reductoisomerase; Provisional; Region: PRK05479 426430006134 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 426430006135 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 426430006136 2-isopropylmalate synthase; Validated; Region: PRK00915 426430006137 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 426430006138 active site 426430006139 catalytic residues [active] 426430006140 metal binding site [ion binding]; metal-binding site 426430006141 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 426430006142 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 426430006143 tartrate dehydrogenase; Region: TTC; TIGR02089 426430006144 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 426430006145 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 426430006146 substrate binding site [chemical binding]; other site 426430006147 ligand binding site [chemical binding]; other site 426430006148 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 426430006149 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 426430006150 substrate binding site [chemical binding]; other site 426430006151 threonine dehydratase; Validated; Region: PRK08639 426430006152 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 426430006153 tetramer interface [polypeptide binding]; other site 426430006154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430006155 catalytic residue [active] 426430006156 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 426430006157 putative Ile/Val binding site [chemical binding]; other site 426430006158 hypothetical protein; Provisional; Region: PRK04351 426430006159 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 426430006160 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 426430006161 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 426430006162 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 426430006163 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 426430006164 RNA binding site [nucleotide binding]; other site 426430006165 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 426430006166 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426430006167 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 426430006168 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426430006169 DNA binding residues [nucleotide binding] 426430006170 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 426430006171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430006172 ATP binding site [chemical binding]; other site 426430006173 Mg2+ binding site [ion binding]; other site 426430006174 G-X-G motif; other site 426430006175 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 426430006176 anti sigma factor interaction site; other site 426430006177 regulatory phosphorylation site [posttranslational modification]; other site 426430006178 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 426430006179 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 426430006180 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 426430006181 PemK-like protein; Region: PemK; pfam02452 426430006182 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 426430006183 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 426430006184 active site 426430006185 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426430006186 dimer interface [polypeptide binding]; other site 426430006187 substrate binding site [chemical binding]; other site 426430006188 catalytic residues [active] 426430006189 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 426430006190 Uncharacterized conserved protein [Function unknown]; Region: COG3402 426430006191 Predicted membrane protein [Function unknown]; Region: COG3428 426430006192 Bacterial PH domain; Region: DUF304; pfam03703 426430006193 Bacterial PH domain; Region: DUF304; pfam03703 426430006194 Bacterial PH domain; Region: DUF304; cl01348 426430006195 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 426430006196 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 426430006197 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426430006198 Soluble P-type ATPase [General function prediction only]; Region: COG4087 426430006199 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 426430006200 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 426430006201 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 426430006202 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 426430006203 Ligand Binding Site [chemical binding]; other site 426430006204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426430006205 dimer interface [polypeptide binding]; other site 426430006206 phosphorylation site [posttranslational modification] 426430006207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430006208 ATP binding site [chemical binding]; other site 426430006209 Mg2+ binding site [ion binding]; other site 426430006210 G-X-G motif; other site 426430006211 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426430006212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430006213 active site 426430006214 phosphorylation site [posttranslational modification] 426430006215 intermolecular recognition site; other site 426430006216 dimerization interface [polypeptide binding]; other site 426430006217 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426430006218 DNA binding site [nucleotide binding] 426430006219 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 426430006220 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 426430006221 ATP binding site [chemical binding]; other site 426430006222 Mg++ binding site [ion binding]; other site 426430006223 motif III; other site 426430006224 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426430006225 nucleotide binding region [chemical binding]; other site 426430006226 ATP-binding site [chemical binding]; other site 426430006227 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 426430006228 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 426430006229 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426430006230 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 426430006231 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 426430006232 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 426430006233 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 426430006234 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 426430006235 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 426430006236 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 426430006237 putative homodimer interface [polypeptide binding]; other site 426430006238 putative homotetramer interface [polypeptide binding]; other site 426430006239 allosteric switch controlling residues; other site 426430006240 putative metal binding site [ion binding]; other site 426430006241 putative homodimer-homodimer interface [polypeptide binding]; other site 426430006242 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 426430006243 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 426430006244 putative active site [active] 426430006245 catalytic site [active] 426430006246 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 426430006247 putative active site [active] 426430006248 catalytic site [active] 426430006249 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 426430006250 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426430006251 Zn2+ binding site [ion binding]; other site 426430006252 Mg2+ binding site [ion binding]; other site 426430006253 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 426430006254 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 426430006255 thiamine phosphate binding site [chemical binding]; other site 426430006256 active site 426430006257 pyrophosphate binding site [ion binding]; other site 426430006258 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 426430006259 substrate binding site [chemical binding]; other site 426430006260 multimerization interface [polypeptide binding]; other site 426430006261 ATP binding site [chemical binding]; other site 426430006262 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 426430006263 dimer interface [polypeptide binding]; other site 426430006264 substrate binding site [chemical binding]; other site 426430006265 ATP binding site [chemical binding]; other site 426430006266 thiaminase II; Region: salvage_TenA; TIGR04306 426430006267 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 426430006268 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 426430006269 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 426430006270 dimer interface [polypeptide binding]; other site 426430006271 ssDNA binding site [nucleotide binding]; other site 426430006272 tetramer (dimer of dimers) interface [polypeptide binding]; other site 426430006273 YwpF-like protein; Region: YwpF; pfam14183 426430006274 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 426430006275 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 426430006276 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 426430006277 hinge; other site 426430006278 active site 426430006279 Predicted membrane protein [Function unknown]; Region: COG4836 426430006280 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 426430006281 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 426430006282 gamma subunit interface [polypeptide binding]; other site 426430006283 epsilon subunit interface [polypeptide binding]; other site 426430006284 LBP interface [polypeptide binding]; other site 426430006285 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 426430006286 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 426430006287 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 426430006288 alpha subunit interaction interface [polypeptide binding]; other site 426430006289 Walker A motif; other site 426430006290 ATP binding site [chemical binding]; other site 426430006291 Walker B motif; other site 426430006292 inhibitor binding site; inhibition site 426430006293 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 426430006294 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 426430006295 core domain interface [polypeptide binding]; other site 426430006296 delta subunit interface [polypeptide binding]; other site 426430006297 epsilon subunit interface [polypeptide binding]; other site 426430006298 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 426430006299 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 426430006300 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 426430006301 beta subunit interaction interface [polypeptide binding]; other site 426430006302 Walker A motif; other site 426430006303 ATP binding site [chemical binding]; other site 426430006304 Walker B motif; other site 426430006305 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 426430006306 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 426430006307 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 426430006308 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 426430006309 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 426430006310 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 426430006311 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 426430006312 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 426430006313 Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468 426430006314 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 426430006315 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 426430006316 active site 426430006317 homodimer interface [polypeptide binding]; other site 426430006318 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426430006319 active site 426430006320 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 426430006321 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 426430006322 dimer interface [polypeptide binding]; other site 426430006323 active site 426430006324 glycine-pyridoxal phosphate binding site [chemical binding]; other site 426430006325 folate binding site [chemical binding]; other site 426430006326 hypothetical protein; Provisional; Region: PRK13690 426430006327 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 426430006328 Low molecular weight phosphatase family; Region: LMWPc; cd00115 426430006329 active site 426430006330 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 426430006331 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 426430006332 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 426430006333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430006334 S-adenosylmethionine binding site [chemical binding]; other site 426430006335 peptide chain release factor 1; Validated; Region: prfA; PRK00591 426430006336 This domain is found in peptide chain release factors; Region: PCRF; smart00937 426430006337 RF-1 domain; Region: RF-1; pfam00472 426430006338 thymidine kinase; Provisional; Region: PRK04296 426430006339 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 426430006340 transcription termination factor Rho; Provisional; Region: rho; PRK09376 426430006341 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 426430006342 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 426430006343 RNA binding site [nucleotide binding]; other site 426430006344 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 426430006345 multimer interface [polypeptide binding]; other site 426430006346 Walker A motif; other site 426430006347 ATP binding site [chemical binding]; other site 426430006348 Walker B motif; other site 426430006349 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 426430006350 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426430006351 NAD binding site [chemical binding]; other site 426430006352 catalytic residues [active] 426430006353 Predicted transcriptional regulators [Transcription]; Region: COG1733 426430006354 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 426430006355 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 426430006356 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 426430006357 hinge; other site 426430006358 active site 426430006359 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 426430006360 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 426430006361 intersubunit interface [polypeptide binding]; other site 426430006362 active site 426430006363 zinc binding site [ion binding]; other site 426430006364 Na+ binding site [ion binding]; other site 426430006365 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 426430006366 CTP synthetase; Validated; Region: pyrG; PRK05380 426430006367 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 426430006368 Catalytic site [active] 426430006369 active site 426430006370 UTP binding site [chemical binding]; other site 426430006371 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 426430006372 active site 426430006373 putative oxyanion hole; other site 426430006374 catalytic triad [active] 426430006375 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 426430006376 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 426430006377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430006378 Coenzyme A binding pocket [chemical binding]; other site 426430006379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426430006380 Coenzyme A binding pocket [chemical binding]; other site 426430006381 pantothenate kinase; Provisional; Region: PRK13317 426430006382 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 426430006383 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 426430006384 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 426430006385 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 426430006386 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 426430006387 metal binding site [ion binding]; metal-binding site 426430006388 S-ribosylhomocysteinase; Provisional; Region: PRK02260 426430006389 Predicted membrane protein [Function unknown]; Region: COG4270 426430006390 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 426430006391 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 426430006392 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 426430006393 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 426430006394 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 426430006395 intersubunit interface [polypeptide binding]; other site 426430006396 active site 426430006397 catalytic residue [active] 426430006398 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 426430006399 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 426430006400 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 426430006401 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 426430006402 dimerization interface [polypeptide binding]; other site 426430006403 DPS ferroxidase diiron center [ion binding]; other site 426430006404 ion pore; other site 426430006405 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 426430006406 EVE domain; Region: EVE; cl00728 426430006407 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 426430006408 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 426430006409 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 426430006410 NADH(P)-binding; Region: NAD_binding_10; pfam13460 426430006411 NAD(P) binding site [chemical binding]; other site 426430006412 putative active site [active] 426430006413 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426430006414 dimerization interface [polypeptide binding]; other site 426430006415 putative DNA binding site [nucleotide binding]; other site 426430006416 putative Zn2+ binding site [ion binding]; other site 426430006417 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 426430006418 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 426430006419 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 426430006420 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426430006421 catalytic residues [active] 426430006422 SAP domain; Region: SAP; pfam02037 426430006423 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 426430006424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430006425 active site 426430006426 motif I; other site 426430006427 motif II; other site 426430006428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430006429 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 426430006430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426430006431 Walker A/P-loop; other site 426430006432 ATP binding site [chemical binding]; other site 426430006433 Q-loop/lid; other site 426430006434 ABC transporter signature motif; other site 426430006435 Walker B; other site 426430006436 D-loop; other site 426430006437 H-loop/switch region; other site 426430006438 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 426430006439 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 426430006440 glutaminase active site [active] 426430006441 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 426430006442 dimer interface [polypeptide binding]; other site 426430006443 active site 426430006444 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 426430006445 dimer interface [polypeptide binding]; other site 426430006446 active site 426430006447 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 426430006448 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 426430006449 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 426430006450 active site 426430006451 P-loop; other site 426430006452 phosphorylation site [posttranslational modification] 426430006453 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 426430006454 HTH domain; Region: HTH_11; pfam08279 426430006455 Mga helix-turn-helix domain; Region: Mga; pfam05043 426430006456 PRD domain; Region: PRD; pfam00874 426430006457 PRD domain; Region: PRD; pfam00874 426430006458 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 426430006459 active site 426430006460 P-loop; other site 426430006461 phosphorylation site [posttranslational modification] 426430006462 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 426430006463 active site 426430006464 phosphorylation site [posttranslational modification] 426430006465 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 426430006466 active site 426430006467 phosphorylation site [posttranslational modification] 426430006468 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 426430006469 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 426430006470 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 426430006471 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 426430006472 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 426430006473 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430006474 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430006475 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430006476 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430006477 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430006478 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 426430006479 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 426430006480 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 426430006481 active site 426430006482 substrate binding site [chemical binding]; other site 426430006483 metal binding site [ion binding]; metal-binding site 426430006484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 426430006485 YbbR-like protein; Region: YbbR; pfam07949 426430006486 TIGR00159 family protein; Region: TIGR00159 426430006487 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 426430006488 Arginase family; Region: Arginase; cd09989 426430006489 active site 426430006490 Mn binding site [ion binding]; other site 426430006491 oligomer interface [polypeptide binding]; other site 426430006492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 426430006493 Transposase; Region: DDE_Tnp_ISL3; pfam01610 426430006494 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 426430006495 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 426430006496 Walker A motif; other site 426430006497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430006498 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426430006499 putative substrate translocation pore; other site 426430006500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430006501 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426430006502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430006503 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 426430006504 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 426430006505 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 426430006506 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 426430006507 substrate binding site; other site 426430006508 dimerization interface; other site 426430006509 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 426430006510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 426430006511 Nucleoside recognition; Region: Gate; pfam07670 426430006512 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 426430006513 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426430006514 ABC-ATPase subunit interface; other site 426430006515 dimer interface [polypeptide binding]; other site 426430006516 putative PBP binding regions; other site 426430006517 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 426430006518 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426430006519 ABC-ATPase subunit interface; other site 426430006520 dimer interface [polypeptide binding]; other site 426430006521 putative PBP binding regions; other site 426430006522 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 426430006523 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 426430006524 siderophore binding site; other site 426430006525 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 426430006526 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 426430006527 dimer interface [polypeptide binding]; other site 426430006528 active site 426430006529 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426430006530 substrate binding site [chemical binding]; other site 426430006531 catalytic residue [active] 426430006532 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 426430006533 IucA / IucC family; Region: IucA_IucC; pfam04183 426430006534 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 426430006535 H+ Antiporter protein; Region: 2A0121; TIGR00900 426430006536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430006537 putative substrate translocation pore; other site 426430006538 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 426430006539 IucA / IucC family; Region: IucA_IucC; pfam04183 426430006540 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 426430006541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 426430006542 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 426430006543 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 426430006544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 426430006545 Asp23 family; Region: Asp23; pfam03780 426430006546 Small integral membrane protein [Function unknown]; Region: COG5547 426430006547 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 426430006548 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 426430006549 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 426430006550 putative NAD(P) binding site [chemical binding]; other site 426430006551 dimer interface [polypeptide binding]; other site 426430006552 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 426430006553 Prostaglandin dehydrogenases; Region: PGDH; cd05288 426430006554 NAD(P) binding site [chemical binding]; other site 426430006555 substrate binding site [chemical binding]; other site 426430006556 dimer interface [polypeptide binding]; other site 426430006557 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 426430006558 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 426430006559 beta-galactosidase; Region: BGL; TIGR03356 426430006560 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 426430006561 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 426430006562 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 426430006563 active site 426430006564 P-loop; other site 426430006565 phosphorylation site [posttranslational modification] 426430006566 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 426430006567 methionine cluster; other site 426430006568 active site 426430006569 phosphorylation site [posttranslational modification] 426430006570 metal binding site [ion binding]; metal-binding site 426430006571 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 426430006572 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 426430006573 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 426430006574 putative substrate binding site [chemical binding]; other site 426430006575 putative ATP binding site [chemical binding]; other site 426430006576 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 426430006577 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 426430006578 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 426430006579 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 426430006580 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 426430006581 NAD-dependent deacetylase; Provisional; Region: PRK00481 426430006582 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 426430006583 NAD+ binding site [chemical binding]; other site 426430006584 substrate binding site [chemical binding]; other site 426430006585 putative Zn binding site [ion binding]; other site 426430006586 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 426430006587 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426430006588 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426430006589 active site 426430006590 catalytic tetrad [active] 426430006591 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 426430006592 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 426430006593 DNA binding residues [nucleotide binding] 426430006594 putative dimer interface [polypeptide binding]; other site 426430006595 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 426430006596 substrate binding site [chemical binding]; other site 426430006597 catalytic residues [active] 426430006598 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 426430006599 Peptidase family M23; Region: Peptidase_M23; pfam01551 426430006600 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 426430006601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 426430006602 active site 426430006603 motif I; other site 426430006604 motif II; other site 426430006605 MAP domain; Region: MAP; pfam03642 426430006606 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 426430006607 acetolactate synthase; Reviewed; Region: PRK08617 426430006608 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426430006609 PYR/PP interface [polypeptide binding]; other site 426430006610 dimer interface [polypeptide binding]; other site 426430006611 TPP binding site [chemical binding]; other site 426430006612 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426430006613 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 426430006614 TPP-binding site [chemical binding]; other site 426430006615 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 426430006616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430006617 Walker A motif; other site 426430006618 ATP binding site [chemical binding]; other site 426430006619 Walker B motif; other site 426430006620 arginine finger; other site 426430006621 Predicted helicase [General function prediction only]; Region: COG4889 426430006622 Predicted helicase [General function prediction only]; Region: COG4889 426430006623 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 426430006624 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 426430006625 23S rRNA interface [nucleotide binding]; other site 426430006626 L3 interface [polypeptide binding]; other site 426430006627 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 426430006628 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 426430006629 dimerization interface 3.5A [polypeptide binding]; other site 426430006630 active site 426430006631 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 426430006632 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 426430006633 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 426430006634 Walker A/P-loop; other site 426430006635 ATP binding site [chemical binding]; other site 426430006636 Q-loop/lid; other site 426430006637 ABC transporter signature motif; other site 426430006638 Walker B; other site 426430006639 D-loop; other site 426430006640 H-loop/switch region; other site 426430006641 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 426430006642 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 426430006643 Walker A/P-loop; other site 426430006644 ATP binding site [chemical binding]; other site 426430006645 Q-loop/lid; other site 426430006646 ABC transporter signature motif; other site 426430006647 Walker B; other site 426430006648 D-loop; other site 426430006649 H-loop/switch region; other site 426430006650 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 426430006651 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 426430006652 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 426430006653 alphaNTD homodimer interface [polypeptide binding]; other site 426430006654 alphaNTD - beta interaction site [polypeptide binding]; other site 426430006655 alphaNTD - beta' interaction site [polypeptide binding]; other site 426430006656 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 426430006657 30S ribosomal protein S11; Validated; Region: PRK05309 426430006658 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 426430006659 30S ribosomal protein S13; Region: bact_S13; TIGR03631 426430006660 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 426430006661 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 426430006662 rRNA binding site [nucleotide binding]; other site 426430006663 predicted 30S ribosome binding site; other site 426430006664 adenylate kinase; Reviewed; Region: adk; PRK00279 426430006665 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 426430006666 AMP-binding site [chemical binding]; other site 426430006667 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 426430006668 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 426430006669 SecY translocase; Region: SecY; pfam00344 426430006670 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 426430006671 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 426430006672 23S rRNA binding site [nucleotide binding]; other site 426430006673 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 426430006674 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 426430006675 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 426430006676 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 426430006677 5S rRNA interface [nucleotide binding]; other site 426430006678 L27 interface [polypeptide binding]; other site 426430006679 23S rRNA interface [nucleotide binding]; other site 426430006680 L5 interface [polypeptide binding]; other site 426430006681 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 426430006682 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 426430006683 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 426430006684 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 426430006685 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 426430006686 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 426430006687 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 426430006688 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 426430006689 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 426430006690 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 426430006691 RNA binding site [nucleotide binding]; other site 426430006692 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 426430006693 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 426430006694 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 426430006695 23S rRNA interface [nucleotide binding]; other site 426430006696 putative translocon interaction site; other site 426430006697 signal recognition particle (SRP54) interaction site; other site 426430006698 L23 interface [polypeptide binding]; other site 426430006699 trigger factor interaction site; other site 426430006700 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 426430006701 23S rRNA interface [nucleotide binding]; other site 426430006702 5S rRNA interface [nucleotide binding]; other site 426430006703 putative antibiotic binding site [chemical binding]; other site 426430006704 L25 interface [polypeptide binding]; other site 426430006705 L27 interface [polypeptide binding]; other site 426430006706 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 426430006707 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 426430006708 G-X-X-G motif; other site 426430006709 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 426430006710 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 426430006711 putative translocon binding site; other site 426430006712 protein-rRNA interface [nucleotide binding]; other site 426430006713 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 426430006714 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 426430006715 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 426430006716 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 426430006717 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 426430006718 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 426430006719 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 426430006720 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 426430006721 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 426430006722 DNA topoisomerase III; Provisional; Region: PRK07726 426430006723 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 426430006724 active site 426430006725 putative interdomain interaction site [polypeptide binding]; other site 426430006726 putative metal-binding site [ion binding]; other site 426430006727 putative nucleotide binding site [chemical binding]; other site 426430006728 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 426430006729 domain I; other site 426430006730 DNA binding groove [nucleotide binding] 426430006731 phosphate binding site [ion binding]; other site 426430006732 domain II; other site 426430006733 domain III; other site 426430006734 nucleotide binding site [chemical binding]; other site 426430006735 catalytic site [active] 426430006736 domain IV; other site 426430006737 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 426430006738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430006739 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 426430006740 Coenzyme A binding pocket [chemical binding]; other site 426430006741 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 426430006742 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 426430006743 Predicted permeases [General function prediction only]; Region: COG0679 426430006744 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426430006745 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 426430006746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 426430006747 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 426430006748 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 426430006749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430006750 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426430006751 putative substrate translocation pore; other site 426430006752 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 426430006753 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426430006754 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 426430006755 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426430006756 FeS/SAM binding site; other site 426430006757 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 426430006758 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 426430006759 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 426430006760 GTP binding site; other site 426430006761 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 426430006762 MoaE interaction surface [polypeptide binding]; other site 426430006763 MoeB interaction surface [polypeptide binding]; other site 426430006764 thiocarboxylated glycine; other site 426430006765 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 426430006766 MoaE homodimer interface [polypeptide binding]; other site 426430006767 MoaD interaction [polypeptide binding]; other site 426430006768 active site residues [active] 426430006769 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 426430006770 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 426430006771 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 426430006772 dimer interface [polypeptide binding]; other site 426430006773 putative functional site; other site 426430006774 putative MPT binding site; other site 426430006775 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 426430006776 trimer interface [polypeptide binding]; other site 426430006777 dimer interface [polypeptide binding]; other site 426430006778 putative active site [active] 426430006779 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 426430006780 MPT binding site; other site 426430006781 trimer interface [polypeptide binding]; other site 426430006782 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 426430006783 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 426430006784 ATP binding site [chemical binding]; other site 426430006785 substrate interface [chemical binding]; other site 426430006786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426430006787 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 426430006788 Walker A/P-loop; other site 426430006789 ATP binding site [chemical binding]; other site 426430006790 Q-loop/lid; other site 426430006791 ABC transporter signature motif; other site 426430006792 Walker B; other site 426430006793 D-loop; other site 426430006794 H-loop/switch region; other site 426430006795 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 426430006796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430006797 dimer interface [polypeptide binding]; other site 426430006798 conserved gate region; other site 426430006799 putative PBP binding loops; other site 426430006800 ABC-ATPase subunit interface; other site 426430006801 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 426430006802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426430006803 substrate binding pocket [chemical binding]; other site 426430006804 membrane-bound complex binding site; other site 426430006805 hinge residues; other site 426430006806 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 426430006807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430006808 Coenzyme A binding pocket [chemical binding]; other site 426430006809 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 426430006810 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 426430006811 active site 426430006812 dimerization interface [polypeptide binding]; other site 426430006813 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 426430006814 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 426430006815 intersubunit interface [polypeptide binding]; other site 426430006816 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426430006817 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 426430006818 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 426430006819 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 426430006820 alpha-gamma subunit interface [polypeptide binding]; other site 426430006821 beta-gamma subunit interface [polypeptide binding]; other site 426430006822 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 426430006823 gamma-beta subunit interface [polypeptide binding]; other site 426430006824 alpha-beta subunit interface [polypeptide binding]; other site 426430006825 urease subunit alpha; Reviewed; Region: ureC; PRK13207 426430006826 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 426430006827 subunit interactions [polypeptide binding]; other site 426430006828 active site 426430006829 flap region; other site 426430006830 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 426430006831 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 426430006832 dimer interface [polypeptide binding]; other site 426430006833 catalytic residues [active] 426430006834 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 426430006835 UreF; Region: UreF; pfam01730 426430006836 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426430006837 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 426430006838 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 426430006839 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 426430006840 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 426430006841 Helix-turn-helix domain; Region: HTH_18; pfam12833 426430006842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426430006843 Surface antigen [General function prediction only]; Region: COG3942 426430006844 CHAP domain; Region: CHAP; pfam05257 426430006845 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 426430006846 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 426430006847 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 426430006848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 426430006849 Surface antigen [General function prediction only]; Region: COG3942 426430006850 CHAP domain; Region: CHAP; pfam05257 426430006851 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 426430006852 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 426430006853 putative ligand binding site [chemical binding]; other site 426430006854 putative NAD binding site [chemical binding]; other site 426430006855 catalytic site [active] 426430006856 hypothetical protein; Provisional; Region: PRK06753 426430006857 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426430006858 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 426430006859 Lysozyme subfamily 2; Region: LYZ2; smart00047 426430006860 Uncharacterized conserved protein [Function unknown]; Region: COG2427 426430006861 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 426430006862 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 426430006863 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 426430006864 4Fe-4S binding domain; Region: Fer4; pfam00037 426430006865 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 426430006866 [4Fe-4S] binding site [ion binding]; other site 426430006867 molybdopterin cofactor binding site; other site 426430006868 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 426430006869 molybdopterin cofactor binding site; other site 426430006870 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 426430006871 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 426430006872 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 426430006873 active site 426430006874 Predicted transcriptional regulator [Transcription]; Region: COG2378 426430006875 HTH domain; Region: HTH_11; pfam08279 426430006876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 426430006877 CAAX protease self-immunity; Region: Abi; pfam02517 426430006878 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 426430006879 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 426430006880 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 426430006881 putative active site [active] 426430006882 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 426430006883 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 426430006884 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430006885 active site 426430006886 motif I; other site 426430006887 motif II; other site 426430006888 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 426430006889 Sodium Bile acid symporter family; Region: SBF; pfam01758 426430006890 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 426430006891 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 426430006892 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 426430006893 active site turn [active] 426430006894 phosphorylation site [posttranslational modification] 426430006895 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 426430006896 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 426430006897 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 426430006898 putative active site [active] 426430006899 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 426430006900 putative hydrophobic ligand binding site [chemical binding]; other site 426430006901 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 426430006902 oxidoreductase; Provisional; Region: PRK07985 426430006903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426430006904 NAD(P) binding site [chemical binding]; other site 426430006905 active site 426430006906 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 426430006907 amidohydrolase; Region: amidohydrolases; TIGR01891 426430006908 metal binding site [ion binding]; metal-binding site 426430006909 dimer interface [polypeptide binding]; other site 426430006910 imidazolonepropionase; Validated; Region: PRK09356 426430006911 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 426430006912 active site 426430006913 urocanate hydratase; Provisional; Region: PRK05414 426430006914 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426430006915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426430006916 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426430006917 dimerization interface [polypeptide binding]; other site 426430006918 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 426430006919 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 426430006920 putative active site [active] 426430006921 putative Mg binding site [ion binding]; other site 426430006922 formimidoylglutamase; Provisional; Region: PRK13775 426430006923 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 426430006924 putative active site [active] 426430006925 putative metal binding site [ion binding]; other site 426430006926 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 426430006927 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 426430006928 tetramer (dimer of dimers) interface [polypeptide binding]; other site 426430006929 active site 426430006930 dimer interface [polypeptide binding]; other site 426430006931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 426430006932 MOSC domain; Region: MOSC; pfam03473 426430006933 3-alpha domain; Region: 3-alpha; pfam03475 426430006934 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 426430006935 active site 426430006936 catalytic residues [active] 426430006937 Uncharacterized conserved protein [Function unknown]; Region: COG1742 426430006938 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 426430006939 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 426430006940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426430006941 Walker A/P-loop; other site 426430006942 ATP binding site [chemical binding]; other site 426430006943 Q-loop/lid; other site 426430006944 ABC transporter signature motif; other site 426430006945 Walker B; other site 426430006946 D-loop; other site 426430006947 H-loop/switch region; other site 426430006948 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 426430006949 Predicted membrane protein [Function unknown]; Region: COG3152 426430006950 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 426430006951 active site 426430006952 DNA binding site [nucleotide binding] 426430006953 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 426430006954 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 426430006955 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 426430006956 homotetramer interface [polypeptide binding]; other site 426430006957 FMN binding site [chemical binding]; other site 426430006958 homodimer contacts [polypeptide binding]; other site 426430006959 putative active site [active] 426430006960 putative substrate binding site [chemical binding]; other site 426430006961 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 426430006962 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 426430006963 oligomer interface [polypeptide binding]; other site 426430006964 metal binding site [ion binding]; metal-binding site 426430006965 metal binding site [ion binding]; metal-binding site 426430006966 putative Cl binding site [ion binding]; other site 426430006967 aspartate ring; other site 426430006968 basic sphincter; other site 426430006969 hydrophobic gate; other site 426430006970 periplasmic entrance; other site 426430006971 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 426430006972 active site 426430006973 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 426430006974 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 426430006975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430006976 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 426430006977 putative substrate translocation pore; other site 426430006978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430006979 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 426430006980 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 426430006981 HlyD family secretion protein; Region: HlyD_3; pfam13437 426430006982 lipoyl-biotinyl attachment site [posttranslational modification]; other site 426430006983 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 426430006984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430006985 putative substrate translocation pore; other site 426430006986 Predicted membrane protein [Function unknown]; Region: COG4640 426430006987 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 426430006988 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426430006989 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426430006990 putative Zn2+ binding site [ion binding]; other site 426430006991 putative DNA binding site [nucleotide binding]; other site 426430006992 Uncharacterized conserved protein [Function unknown]; Region: COG1434 426430006993 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 426430006994 putative active site [active] 426430006995 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 426430006996 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 426430006997 Walker A/P-loop; other site 426430006998 ATP binding site [chemical binding]; other site 426430006999 Q-loop/lid; other site 426430007000 ABC transporter signature motif; other site 426430007001 Walker B; other site 426430007002 D-loop; other site 426430007003 H-loop/switch region; other site 426430007004 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 426430007005 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 426430007006 FtsX-like permease family; Region: FtsX; pfam02687 426430007007 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426430007008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430007009 active site 426430007010 phosphorylation site [posttranslational modification] 426430007011 intermolecular recognition site; other site 426430007012 dimerization interface [polypeptide binding]; other site 426430007013 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426430007014 DNA binding site [nucleotide binding] 426430007015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426430007016 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426430007017 dimerization interface [polypeptide binding]; other site 426430007018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426430007019 dimer interface [polypeptide binding]; other site 426430007020 phosphorylation site [posttranslational modification] 426430007021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430007022 ATP binding site [chemical binding]; other site 426430007023 Mg2+ binding site [ion binding]; other site 426430007024 G-X-G motif; other site 426430007025 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 426430007026 LytTr DNA-binding domain; Region: LytTR; smart00850 426430007027 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 426430007028 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 426430007029 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 426430007030 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 426430007031 L-lactate permease; Region: Lactate_perm; cl00701 426430007032 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 426430007033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430007034 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 426430007035 Coenzyme A binding pocket [chemical binding]; other site 426430007036 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 426430007037 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 426430007038 NAD(P) binding site [chemical binding]; other site 426430007039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430007040 Coenzyme A binding pocket [chemical binding]; other site 426430007041 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 426430007042 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426430007043 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426430007044 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 426430007045 Predicted membrane protein [Function unknown]; Region: COG1511 426430007046 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 426430007047 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 426430007048 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 426430007049 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 426430007050 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 426430007051 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 426430007052 Cl binding site [ion binding]; other site 426430007053 oligomer interface [polypeptide binding]; other site 426430007054 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 426430007055 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 426430007056 active site turn [active] 426430007057 phosphorylation site [posttranslational modification] 426430007058 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 426430007059 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 426430007060 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426430007061 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426430007062 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 426430007063 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 426430007064 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 426430007065 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 426430007066 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 426430007067 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426430007068 MarR family; Region: MarR_2; pfam12802 426430007069 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 426430007070 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 426430007071 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 426430007072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430007073 putative substrate translocation pore; other site 426430007074 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 426430007075 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 426430007076 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 426430007077 DNA binding residues [nucleotide binding] 426430007078 dimer interface [polypeptide binding]; other site 426430007079 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 426430007080 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426430007081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430007082 active site 426430007083 phosphorylation site [posttranslational modification] 426430007084 intermolecular recognition site; other site 426430007085 dimerization interface [polypeptide binding]; other site 426430007086 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426430007087 DNA binding residues [nucleotide binding] 426430007088 dimerization interface [polypeptide binding]; other site 426430007089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 426430007090 Histidine kinase; Region: HisKA_3; pfam07730 426430007091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430007092 ATP binding site [chemical binding]; other site 426430007093 Mg2+ binding site [ion binding]; other site 426430007094 G-X-G motif; other site 426430007095 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426430007096 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 426430007097 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 426430007098 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 426430007099 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 426430007100 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 426430007101 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 426430007102 [4Fe-4S] binding site [ion binding]; other site 426430007103 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426430007104 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426430007105 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426430007106 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 426430007107 molybdopterin cofactor binding site; other site 426430007108 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 426430007109 active site 426430007110 SAM binding site [chemical binding]; other site 426430007111 homodimer interface [polypeptide binding]; other site 426430007112 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 426430007113 [2Fe-2S] cluster binding site [ion binding]; other site 426430007114 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 426430007115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426430007116 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426430007117 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 426430007118 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 426430007119 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 426430007120 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 426430007121 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 426430007122 putative active site [active] 426430007123 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 426430007124 active site 426430007125 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 426430007126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430007127 Coenzyme A binding pocket [chemical binding]; other site 426430007128 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 426430007129 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 426430007130 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 426430007131 putative hydrophobic ligand binding site [chemical binding]; other site 426430007132 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 426430007133 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 426430007134 intersubunit interface [polypeptide binding]; other site 426430007135 YodA lipocalin-like domain; Region: YodA; pfam09223 426430007136 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 426430007137 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 426430007138 Thioredoxin; Region: Thioredoxin_4; cl17273 426430007139 FemAB family; Region: FemAB; pfam02388 426430007140 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426430007141 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426430007142 Walker A/P-loop; other site 426430007143 ATP binding site [chemical binding]; other site 426430007144 Q-loop/lid; other site 426430007145 ABC transporter signature motif; other site 426430007146 Walker B; other site 426430007147 D-loop; other site 426430007148 H-loop/switch region; other site 426430007149 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426430007150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430007151 dimer interface [polypeptide binding]; other site 426430007152 conserved gate region; other site 426430007153 putative PBP binding loops; other site 426430007154 ABC-ATPase subunit interface; other site 426430007155 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426430007156 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426430007157 substrate binding pocket [chemical binding]; other site 426430007158 membrane-bound complex binding site; other site 426430007159 hinge residues; other site 426430007160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430007161 putative substrate translocation pore; other site 426430007162 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426430007163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430007164 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426430007165 catalytic core [active] 426430007166 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426430007167 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 426430007168 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 426430007169 B domain; Region: B; pfam02216 426430007170 B domain; Region: B; pfam02216 426430007171 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 426430007172 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 426430007173 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 426430007174 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 426430007175 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 426430007176 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 426430007177 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 426430007178 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426430007179 catalytic residue [active] 426430007180 biotin synthase; Validated; Region: PRK06256 426430007181 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426430007182 FeS/SAM binding site; other site 426430007183 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 426430007184 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426430007185 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 426430007186 inhibitor-cofactor binding pocket; inhibition site 426430007187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430007188 catalytic residue [active] 426430007189 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 426430007190 AAA domain; Region: AAA_26; pfam13500 426430007191 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 426430007192 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 426430007193 Walker A/P-loop; other site 426430007194 ATP binding site [chemical binding]; other site 426430007195 Q-loop/lid; other site 426430007196 ABC transporter signature motif; other site 426430007197 Walker B; other site 426430007198 D-loop; other site 426430007199 H-loop/switch region; other site 426430007200 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426430007201 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426430007202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426430007203 Walker A/P-loop; other site 426430007204 ATP binding site [chemical binding]; other site 426430007205 Q-loop/lid; other site 426430007206 ABC transporter signature motif; other site 426430007207 Walker B; other site 426430007208 D-loop; other site 426430007209 H-loop/switch region; other site 426430007210 Predicted membrane protein [Function unknown]; Region: COG2246 426430007211 GtrA-like protein; Region: GtrA; pfam04138 426430007212 glycerate kinase; Region: TIGR00045 426430007213 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 426430007214 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 426430007215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430007216 putative substrate translocation pore; other site 426430007217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 426430007218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 426430007219 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 426430007220 putative phosphoesterase; Region: acc_ester; TIGR03729 426430007221 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 426430007222 Spore germination protein; Region: Spore_permease; cl17796 426430007223 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 426430007224 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 426430007225 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 426430007226 Beta-lactamase; Region: Beta-lactamase; pfam00144 426430007227 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426430007228 extended (e) SDRs; Region: SDR_e; cd08946 426430007229 NAD(P) binding site [chemical binding]; other site 426430007230 active site 426430007231 substrate binding site [chemical binding]; other site 426430007232 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 426430007233 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 426430007234 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 426430007235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430007236 putative substrate translocation pore; other site 426430007237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430007238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430007239 dimer interface [polypeptide binding]; other site 426430007240 conserved gate region; other site 426430007241 ABC-ATPase subunit interface; other site 426430007242 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 426430007243 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 426430007244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430007245 dimer interface [polypeptide binding]; other site 426430007246 conserved gate region; other site 426430007247 putative PBP binding loops; other site 426430007248 ABC-ATPase subunit interface; other site 426430007249 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 426430007250 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 426430007251 Walker A/P-loop; other site 426430007252 ATP binding site [chemical binding]; other site 426430007253 Q-loop/lid; other site 426430007254 ABC transporter signature motif; other site 426430007255 Walker B; other site 426430007256 D-loop; other site 426430007257 H-loop/switch region; other site 426430007258 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 426430007259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 426430007260 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 426430007261 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 426430007262 amino acid transporter; Region: 2A0306; TIGR00909 426430007263 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 426430007264 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 426430007265 substrate binding pocket [chemical binding]; other site 426430007266 catalytic triad [active] 426430007267 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 426430007268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430007269 putative substrate translocation pore; other site 426430007270 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 426430007271 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 426430007272 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 426430007273 Walker A/P-loop; other site 426430007274 ATP binding site [chemical binding]; other site 426430007275 Q-loop/lid; other site 426430007276 ABC transporter signature motif; other site 426430007277 Walker B; other site 426430007278 D-loop; other site 426430007279 H-loop/switch region; other site 426430007280 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 426430007281 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 426430007282 oligomer interface [polypeptide binding]; other site 426430007283 active site 426430007284 metal binding site [ion binding]; metal-binding site 426430007285 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 426430007286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 426430007287 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 426430007288 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 426430007289 active site 426430007290 FMN binding site [chemical binding]; other site 426430007291 substrate binding site [chemical binding]; other site 426430007292 3Fe-4S cluster binding site [ion binding]; other site 426430007293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430007294 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426430007295 putative substrate translocation pore; other site 426430007296 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 426430007297 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426430007298 Walker A/P-loop; other site 426430007299 ATP binding site [chemical binding]; other site 426430007300 Q-loop/lid; other site 426430007301 ABC transporter signature motif; other site 426430007302 Walker B; other site 426430007303 D-loop; other site 426430007304 H-loop/switch region; other site 426430007305 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426430007306 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 426430007307 Walker A/P-loop; other site 426430007308 ATP binding site [chemical binding]; other site 426430007309 Q-loop/lid; other site 426430007310 ABC transporter signature motif; other site 426430007311 Walker B; other site 426430007312 D-loop; other site 426430007313 H-loop/switch region; other site 426430007314 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426430007315 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426430007316 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 426430007317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430007318 dimer interface [polypeptide binding]; other site 426430007319 conserved gate region; other site 426430007320 putative PBP binding loops; other site 426430007321 ABC-ATPase subunit interface; other site 426430007322 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426430007323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426430007324 dimer interface [polypeptide binding]; other site 426430007325 conserved gate region; other site 426430007326 putative PBP binding loops; other site 426430007327 ABC-ATPase subunit interface; other site 426430007328 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426430007329 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 426430007330 substrate binding site [chemical binding]; other site 426430007331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 426430007332 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 426430007333 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 426430007334 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 426430007335 classical (c) SDRs; Region: SDR_c; cd05233 426430007336 NAD(P) binding site [chemical binding]; other site 426430007337 active site 426430007338 AbgT putative transporter family; Region: ABG_transport; pfam03806 426430007339 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 426430007340 Uncharacterized conserved protein [Function unknown]; Region: COG2128 426430007341 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 426430007342 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 426430007343 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 426430007344 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 426430007345 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 426430007346 classical (c) SDRs; Region: SDR_c; cd05233 426430007347 NAD(P) binding site [chemical binding]; other site 426430007348 active site 426430007349 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 426430007350 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430007351 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430007352 Protein of unknown function, DUF576; Region: DUF576; pfam04507 426430007353 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 426430007354 PLD-like domain; Region: PLDc_2; pfam13091 426430007355 putative homodimer interface [polypeptide binding]; other site 426430007356 putative active site [active] 426430007357 catalytic site [active] 426430007358 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 426430007359 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426430007360 ATP binding site [chemical binding]; other site 426430007361 putative Mg++ binding site [ion binding]; other site 426430007362 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426430007363 nucleotide binding region [chemical binding]; other site 426430007364 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 426430007365 ATP-binding site [chemical binding]; other site 426430007366 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 426430007367 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 426430007368 active site 426430007369 8-oxo-dGMP binding site [chemical binding]; other site 426430007370 nudix motif; other site 426430007371 metal binding site [ion binding]; metal-binding site 426430007372 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 426430007373 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 426430007374 active site 426430007375 substrate binding site [chemical binding]; other site 426430007376 metal binding site [ion binding]; metal-binding site 426430007377 H+ Antiporter protein; Region: 2A0121; TIGR00900 426430007378 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 426430007379 legume lectins; Region: lectin_L-type; cl14058 426430007380 homotetramer interaction site [polypeptide binding]; other site 426430007381 carbohydrate binding site [chemical binding]; other site 426430007382 metal binding site [ion binding]; metal-binding site 426430007383 G5 domain; Region: G5; pfam07501 426430007384 G5 domain; Region: G5; pfam07501 426430007385 G5 domain; Region: G5; pfam07501 426430007386 G5 domain; Region: G5; pfam07501 426430007387 G5 domain; Region: G5; pfam07501 426430007388 G5 domain; Region: G5; pfam07501 426430007389 G5 domain; Region: G5; pfam07501 426430007390 G5 domain; Region: G5; pfam07501 426430007391 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 426430007392 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 426430007393 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426430007394 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 426430007395 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426430007396 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 426430007397 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 426430007398 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 426430007399 active site 426430007400 tetramer interface; other site 426430007401 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 426430007402 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 426430007403 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 426430007404 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 426430007405 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 426430007406 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 426430007407 GntP family permease; Region: GntP_permease; pfam02447 426430007408 fructuronate transporter; Provisional; Region: PRK10034; cl15264 426430007409 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 426430007410 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 426430007411 N- and C-terminal domain interface [polypeptide binding]; other site 426430007412 active site 426430007413 catalytic site [active] 426430007414 metal binding site [ion binding]; metal-binding site 426430007415 carbohydrate binding site [chemical binding]; other site 426430007416 ATP binding site [chemical binding]; other site 426430007417 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426430007418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426430007419 DNA-binding site [nucleotide binding]; DNA binding site 426430007420 FCD domain; Region: FCD; pfam07729 426430007421 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 426430007422 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 426430007423 DNA binding residues [nucleotide binding] 426430007424 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 426430007425 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 426430007426 synthetase active site [active] 426430007427 NTP binding site [chemical binding]; other site 426430007428 metal binding site [ion binding]; metal-binding site 426430007429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 426430007430 Predicted membrane protein [Function unknown]; Region: COG1289 426430007431 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 426430007432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430007433 D-galactonate transporter; Region: 2A0114; TIGR00893 426430007434 putative substrate translocation pore; other site 426430007435 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 426430007436 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 426430007437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426430007438 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426430007439 putative substrate translocation pore; other site 426430007440 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426430007441 MarR family; Region: MarR; pfam01047 426430007442 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 426430007443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426430007444 Walker A/P-loop; other site 426430007445 ATP binding site [chemical binding]; other site 426430007446 Q-loop/lid; other site 426430007447 ABC transporter signature motif; other site 426430007448 Walker B; other site 426430007449 D-loop; other site 426430007450 H-loop/switch region; other site 426430007451 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 426430007452 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 426430007453 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 426430007454 Uncharacterized membrane protein [Function unknown]; Region: COG3949 426430007455 Predicted esterase [General function prediction only]; Region: COG0400 426430007456 putative hydrolase; Provisional; Region: PRK11460 426430007457 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 426430007458 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426430007459 Zn binding site [ion binding]; other site 426430007460 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 426430007461 Zn binding site [ion binding]; other site 426430007462 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426430007463 MarR family; Region: MarR; pfam01047 426430007464 Predicted acetyltransferase [General function prediction only]; Region: COG2388 426430007465 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 426430007466 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 426430007467 putative metal binding site [ion binding]; other site 426430007468 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 426430007469 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 426430007470 dimer interface [polypeptide binding]; other site 426430007471 FMN binding site [chemical binding]; other site 426430007472 D-lactate dehydrogenase; Provisional; Region: PRK12480 426430007473 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 426430007474 ligand binding site [chemical binding]; other site 426430007475 NAD binding site [chemical binding]; other site 426430007476 homodimer interface [polypeptide binding]; other site 426430007477 catalytic site [active] 426430007478 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 426430007479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426430007480 active site 426430007481 motif I; other site 426430007482 motif II; other site 426430007483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 426430007484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426430007485 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 426430007486 Walker A/P-loop; other site 426430007487 ATP binding site [chemical binding]; other site 426430007488 Q-loop/lid; other site 426430007489 ABC transporter signature motif; other site 426430007490 Walker B; other site 426430007491 D-loop; other site 426430007492 H-loop/switch region; other site 426430007493 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 426430007494 active site 426430007495 catalytic site [active] 426430007496 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 426430007497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430007498 Coenzyme A binding pocket [chemical binding]; other site 426430007499 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 426430007500 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 426430007501 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 426430007502 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 426430007503 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 426430007504 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 426430007505 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 426430007506 EamA-like transporter family; Region: EamA; pfam00892 426430007507 EamA-like transporter family; Region: EamA; pfam00892 426430007508 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 426430007509 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 426430007510 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 426430007511 catalytic residues [active] 426430007512 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 426430007513 active site 426430007514 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 426430007515 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 426430007516 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 426430007517 active site turn [active] 426430007518 phosphorylation site [posttranslational modification] 426430007519 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 426430007520 HPr interaction site; other site 426430007521 glycerol kinase (GK) interaction site [polypeptide binding]; other site 426430007522 active site 426430007523 phosphorylation site [posttranslational modification] 426430007524 pyruvate oxidase; Provisional; Region: PRK08611 426430007525 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 426430007526 PYR/PP interface [polypeptide binding]; other site 426430007527 tetramer interface [polypeptide binding]; other site 426430007528 dimer interface [polypeptide binding]; other site 426430007529 TPP binding site [chemical binding]; other site 426430007530 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426430007531 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 426430007532 TPP-binding site [chemical binding]; other site 426430007533 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 426430007534 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 426430007535 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426430007536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426430007537 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 426430007538 putative dimerization interface [polypeptide binding]; other site 426430007539 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 426430007540 Surface antigen [General function prediction only]; Region: COG3942 426430007541 CHAP domain; Region: CHAP; pfam05257 426430007542 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 426430007543 homodimer interface [polypeptide binding]; other site 426430007544 catalytic residues [active] 426430007545 NAD binding site [chemical binding]; other site 426430007546 substrate binding pocket [chemical binding]; other site 426430007547 flexible flap; other site 426430007548 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 426430007549 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 426430007550 dimer interface [polypeptide binding]; other site 426430007551 active site 426430007552 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 426430007553 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 426430007554 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 426430007555 DNA binding site [nucleotide binding] 426430007556 active site 426430007557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430007558 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426430007559 Walker A motif; other site 426430007560 ATP binding site [chemical binding]; other site 426430007561 Walker B motif; other site 426430007562 arginine finger; other site 426430007563 UvrB/uvrC motif; Region: UVR; pfam02151 426430007564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426430007565 Walker A motif; other site 426430007566 ATP binding site [chemical binding]; other site 426430007567 Walker B motif; other site 426430007568 arginine finger; other site 426430007569 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 426430007570 Virus attachment protein p12 family; Region: P12; pfam12669 426430007571 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 426430007572 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 426430007573 G1 box; other site 426430007574 GTP/Mg2+ binding site [chemical binding]; other site 426430007575 Switch I region; other site 426430007576 G2 box; other site 426430007577 G3 box; other site 426430007578 Switch II region; other site 426430007579 G4 box; other site 426430007580 G5 box; other site 426430007581 Nucleoside recognition; Region: Gate; pfam07670 426430007582 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 426430007583 Nucleoside recognition; Region: Gate; pfam07670 426430007584 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 426430007585 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 426430007586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426430007587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426430007588 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 426430007589 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 426430007590 Glutamate binding site [chemical binding]; other site 426430007591 homodimer interface [polypeptide binding]; other site 426430007592 NAD binding site [chemical binding]; other site 426430007593 catalytic residues [active] 426430007594 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 426430007595 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 426430007596 active site 426430007597 substrate binding site [chemical binding]; other site 426430007598 trimer interface [polypeptide binding]; other site 426430007599 CoA binding site [chemical binding]; other site 426430007600 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 426430007601 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 426430007602 metal-binding site [ion binding] 426430007603 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 426430007604 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 426430007605 metal-binding site [ion binding] 426430007606 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426430007607 Soluble P-type ATPase [General function prediction only]; Region: COG4087 426430007608 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 426430007609 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 426430007610 metal-binding site [ion binding] 426430007611 D-lactate dehydrogenase; Validated; Region: PRK08605 426430007612 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 426430007613 homodimer interface [polypeptide binding]; other site 426430007614 ligand binding site [chemical binding]; other site 426430007615 NAD binding site [chemical binding]; other site 426430007616 catalytic site [active] 426430007617 transaminase; Reviewed; Region: PRK08068 426430007618 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426430007619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430007620 homodimer interface [polypeptide binding]; other site 426430007621 catalytic residue [active] 426430007622 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 426430007623 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426430007624 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 426430007625 active site lid residues [active] 426430007626 substrate binding pocket [chemical binding]; other site 426430007627 catalytic residues [active] 426430007628 substrate-Mg2+ binding site; other site 426430007629 aspartate-rich region 1; other site 426430007630 aspartate-rich region 2; other site 426430007631 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426430007632 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426430007633 active site 426430007634 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 426430007635 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426430007636 Surface antigen [General function prediction only]; Region: COG3942 426430007637 CHAP domain; Region: CHAP; pfam05257 426430007638 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426430007639 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 426430007640 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 426430007641 catalytic triad [active] 426430007642 catalytic triad [active] 426430007643 oxyanion hole [active] 426430007644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430007645 Coenzyme A binding pocket [chemical binding]; other site 426430007646 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426430007647 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426430007648 catalytic residue [active] 426430007649 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 426430007650 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 426430007651 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426430007652 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426430007653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 426430007654 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 426430007655 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426430007656 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 426430007657 NmrA-like family; Region: NmrA; pfam05368 426430007658 NADP binding site [chemical binding]; other site 426430007659 active site 426430007660 regulatory binding site [polypeptide binding]; other site 426430007661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 426430007662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426430007663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426430007664 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 426430007665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426430007666 NAD(P) binding site [chemical binding]; other site 426430007667 active site 426430007668 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 426430007669 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426430007670 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 426430007671 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 426430007672 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 426430007673 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 426430007674 Nucleoside recognition; Region: Gate; pfam07670 426430007675 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 426430007676 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 426430007677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 426430007678 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 426430007679 Phosphotransferase enzyme family; Region: APH; pfam01636 426430007680 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 426430007681 active site 426430007682 ATP binding site [chemical binding]; other site 426430007683 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 426430007684 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 426430007685 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 426430007686 quinone interaction residues [chemical binding]; other site 426430007687 active site 426430007688 catalytic residues [active] 426430007689 FMN binding site [chemical binding]; other site 426430007690 substrate binding site [chemical binding]; other site 426430007691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 426430007692 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 426430007693 dimer interface [polypeptide binding]; other site 426430007694 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426430007695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426430007696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426430007697 Predicted acyl esterases [General function prediction only]; Region: COG2936 426430007698 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 426430007699 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 426430007700 tetramerization interface [polypeptide binding]; other site 426430007701 active site 426430007702 pantoate--beta-alanine ligase; Region: panC; TIGR00018 426430007703 Pantoate-beta-alanine ligase; Region: PanC; cd00560 426430007704 active site 426430007705 ATP-binding site [chemical binding]; other site 426430007706 pantoate-binding site; other site 426430007707 HXXH motif; other site 426430007708 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 426430007709 oligomerization interface [polypeptide binding]; other site 426430007710 active site 426430007711 metal binding site [ion binding]; metal-binding site 426430007712 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 426430007713 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 426430007714 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 426430007715 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 426430007716 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 426430007717 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 426430007718 tetramer (dimer of dimers) interface [polypeptide binding]; other site 426430007719 NAD binding site [chemical binding]; other site 426430007720 dimer interface [polypeptide binding]; other site 426430007721 substrate binding site [chemical binding]; other site 426430007722 amino acid transporter; Region: 2A0306; TIGR00909 426430007723 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 426430007724 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 426430007725 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426430007726 inhibitor-cofactor binding pocket; inhibition site 426430007727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430007728 catalytic residue [active] 426430007729 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 426430007730 catalytic residue [active] 426430007731 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 426430007732 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 426430007733 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 426430007734 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426430007735 acyl-activating enzyme (AAE) consensus motif; other site 426430007736 AMP binding site [chemical binding]; other site 426430007737 active site 426430007738 CoA binding site [chemical binding]; other site 426430007739 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 426430007740 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 426430007741 choline dehydrogenase; Validated; Region: PRK02106 426430007742 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 426430007743 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 426430007744 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 426430007745 tetramerization interface [polypeptide binding]; other site 426430007746 NAD(P) binding site [chemical binding]; other site 426430007747 catalytic residues [active] 426430007748 Predicted transcriptional regulators [Transcription]; Region: COG1510 426430007749 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426430007750 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 426430007751 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 426430007752 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426430007753 FeS/SAM binding site; other site 426430007754 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 426430007755 Class III ribonucleotide reductase; Region: RNR_III; cd01675 426430007756 effector binding site; other site 426430007757 active site 426430007758 Zn binding site [ion binding]; other site 426430007759 glycine loop; other site 426430007760 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 426430007761 Citrate transporter; Region: CitMHS; pfam03600 426430007762 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 426430007763 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 426430007764 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 426430007765 Flavodoxin; Region: Flavodoxin_1; pfam00258 426430007766 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 426430007767 FAD binding pocket [chemical binding]; other site 426430007768 FAD binding motif [chemical binding]; other site 426430007769 catalytic residues [active] 426430007770 NAD binding pocket [chemical binding]; other site 426430007771 phosphate binding motif [ion binding]; other site 426430007772 beta-alpha-beta structure motif; other site 426430007773 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 426430007774 catalytic residues [active] 426430007775 dimer interface [polypeptide binding]; other site 426430007776 FtsX-like permease family; Region: FtsX; pfam02687 426430007777 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 426430007778 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 426430007779 Walker A/P-loop; other site 426430007780 ATP binding site [chemical binding]; other site 426430007781 Q-loop/lid; other site 426430007782 ABC transporter signature motif; other site 426430007783 Walker B; other site 426430007784 D-loop; other site 426430007785 H-loop/switch region; other site 426430007786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426430007787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426430007788 ATP binding site [chemical binding]; other site 426430007789 Mg2+ binding site [ion binding]; other site 426430007790 G-X-G motif; other site 426430007791 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426430007792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426430007793 active site 426430007794 phosphorylation site [posttranslational modification] 426430007795 intermolecular recognition site; other site 426430007796 dimerization interface [polypeptide binding]; other site 426430007797 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426430007798 DNA binding site [nucleotide binding] 426430007799 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 426430007800 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 426430007801 dimer interface [polypeptide binding]; other site 426430007802 active site 426430007803 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 426430007804 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426430007805 MarR family; Region: MarR_2; pfam12802 426430007806 Predicted esterase [General function prediction only]; Region: COG0627 426430007807 S-formylglutathione hydrolase; Region: PLN02442 426430007808 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 426430007809 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 426430007810 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426430007811 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426430007812 ligand binding site [chemical binding]; other site 426430007813 flexible hinge region; other site 426430007814 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426430007815 carbamate kinase; Reviewed; Region: PRK12686 426430007816 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 426430007817 putative substrate binding site [chemical binding]; other site 426430007818 nucleotide binding site [chemical binding]; other site 426430007819 nucleotide binding site [chemical binding]; other site 426430007820 homodimer interface [polypeptide binding]; other site 426430007821 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 426430007822 ornithine carbamoyltransferase; Validated; Region: PRK02102 426430007823 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 426430007824 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 426430007825 arginine deiminase; Provisional; Region: PRK01388 426430007826 Arginine repressor [Transcription]; Region: ArgR; COG1438 426430007827 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 426430007828 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 426430007829 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 426430007830 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 426430007831 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 426430007832 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 426430007833 active site 426430007834 Zn binding site [ion binding]; other site 426430007835 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 426430007836 HTH domain; Region: HTH_11; pfam08279 426430007837 PRD domain; Region: PRD; pfam00874 426430007838 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 426430007839 active site 426430007840 P-loop; other site 426430007841 phosphorylation site [posttranslational modification] 426430007842 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 426430007843 active site 426430007844 phosphorylation site [posttranslational modification] 426430007845 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 426430007846 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 426430007847 active site 426430007848 P-loop; other site 426430007849 phosphorylation site [posttranslational modification] 426430007850 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 426430007851 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 426430007852 active site 426430007853 phosphorylation site [posttranslational modification] 426430007854 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 426430007855 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 426430007856 Predicted membrane protein [Function unknown]; Region: COG1511 426430007857 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 426430007858 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 426430007859 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 426430007860 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 426430007861 CHAP domain; Region: CHAP; pfam05257 426430007862 Isochorismatase family; Region: Isochorismatase; pfam00857 426430007863 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 426430007864 catalytic triad [active] 426430007865 conserved cis-peptide bond; other site 426430007866 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 426430007867 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426430007868 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 426430007869 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 426430007870 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 426430007871 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 426430007872 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 426430007873 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 426430007874 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 426430007875 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 426430007876 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426430007877 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 426430007878 SecY translocase; Region: SecY; pfam00344 426430007879 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 426430007880 legume lectins; Region: lectin_L-type; cd01951 426430007881 homotetramer interaction site [polypeptide binding]; other site 426430007882 carbohydrate binding site [chemical binding]; other site 426430007883 metal binding site [ion binding]; metal-binding site 426430007884 Putative Ig domain; Region: He_PIG; pfam05345 426430007885 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 426430007886 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 426430007887 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 426430007888 methionine sulfoxide reductase A; Provisional; Region: PRK05528 426430007889 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 426430007890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426430007891 Coenzyme A binding pocket [chemical binding]; other site 426430007892 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 426430007893 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 426430007894 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426430007895 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 426430007896 Chain length determinant protein; Region: Wzz; cl15801 426430007897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426430007898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426430007899 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 426430007900 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 426430007901 DXD motif; other site 426430007902 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 426430007903 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 426430007904 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 426430007905 Acyltransferase family; Region: Acyl_transf_3; pfam01757 426430007906 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 426430007907 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 426430007908 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 426430007909 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 426430007910 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 426430007911 metal binding site [ion binding]; metal-binding site 426430007912 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 426430007913 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 426430007914 substrate binding site [chemical binding]; other site 426430007915 glutamase interaction surface [polypeptide binding]; other site 426430007916 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 426430007917 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 426430007918 catalytic residues [active] 426430007919 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 426430007920 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 426430007921 putative active site [active] 426430007922 oxyanion strand; other site 426430007923 catalytic triad [active] 426430007924 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 426430007925 putative active site pocket [active] 426430007926 4-fold oligomerization interface [polypeptide binding]; other site 426430007927 metal binding residues [ion binding]; metal-binding site 426430007928 3-fold/trimer interface [polypeptide binding]; other site 426430007929 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 426430007930 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426430007931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426430007932 homodimer interface [polypeptide binding]; other site 426430007933 catalytic residue [active] 426430007934 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 426430007935 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 426430007936 NAD binding site [chemical binding]; other site 426430007937 dimerization interface [polypeptide binding]; other site 426430007938 product binding site; other site 426430007939 substrate binding site [chemical binding]; other site 426430007940 zinc binding site [ion binding]; other site 426430007941 catalytic residues [active] 426430007942 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 426430007943 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 426430007944 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 426430007945 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 426430007946 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 426430007947 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 426430007948 putative active site [active] 426430007949 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 426430007950 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 426430007951 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 426430007952 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 426430007953 Walker A/P-loop; other site 426430007954 ATP binding site [chemical binding]; other site 426430007955 Q-loop/lid; other site 426430007956 ABC transporter signature motif; other site 426430007957 Walker B; other site 426430007958 D-loop; other site 426430007959 H-loop/switch region; other site 426430007960 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 426430007961 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 426430007962 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 426430007963 Walker A/P-loop; other site 426430007964 ATP binding site [chemical binding]; other site 426430007965 Q-loop/lid; other site 426430007966 ABC transporter signature motif; other site 426430007967 Walker B; other site 426430007968 D-loop; other site 426430007969 H-loop/switch region; other site 426430007970 hypothetical protein; Provisional; Region: PRK13661 426430007971 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 426430007972 Uncharacterized conserved protein [Function unknown]; Region: COG1912 426430007973 Uncharacterized conserved protein [Function unknown]; Region: COG2353 426430007974 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 426430007975 Strictosidine synthase; Region: Str_synth; pfam03088 426430007976 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 426430007977 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 426430007978 active site residue [active] 426430007979 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 426430007980 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 426430007981 putative substrate binding pocket [chemical binding]; other site 426430007982 AC domain interface; other site 426430007983 catalytic triad [active] 426430007984 AB domain interface; other site 426430007985 interchain disulfide; other site 426430007986 hypothetical protein; Validated; Region: PRK07668 426430007987 Predicted transcriptional regulators [Transcription]; Region: COG1695 426430007988 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 426430007989 DinB superfamily; Region: DinB_2; pfam12867 426430007990 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 426430007991 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 426430007992 transmembrane helices; other site 426430007993 Predicted permeases [General function prediction only]; Region: RarD; COG2962 426430007994 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 426430007995 hypothetical protein; Provisional; Region: PRK07758 426430007996 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 426430007997 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 426430007998 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 426430007999 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 426430008000 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 426430008001 Walker A/P-loop; other site 426430008002 ATP binding site [chemical binding]; other site 426430008003 Q-loop/lid; other site 426430008004 ABC transporter signature motif; other site 426430008005 Walker B; other site 426430008006 D-loop; other site 426430008007 H-loop/switch region; other site 426430008008 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 426430008009 FtsX-like permease family; Region: FtsX; pfam02687 426430008010 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426430008011 Integrase core domain; Region: rve; pfam00665 426430008012 Integrase core domain; Region: rve_3; cl15866 426430008013 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 426430008014 Integrase core domain; Region: rve_3; cl15866 426430008015 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426430008016 DNA-binding site [nucleotide binding]; DNA binding site 426430008017 RNA-binding motif; other site 426430008018 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426430008019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426430008020 non-specific DNA binding site [nucleotide binding]; other site 426430008021 salt bridge; other site 426430008022 sequence-specific DNA binding site [nucleotide binding]; other site 426430008023 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 426430008024 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 426430008025 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 426430008026 ParB-like nuclease domain; Region: ParBc; pfam02195 426430008027 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 426430008028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426430008029 S-adenosylmethionine binding site [chemical binding]; other site 426430008030 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 426430008031 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 426430008032 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 426430008033 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 426430008034 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 426430008035 trmE is a tRNA modification GTPase; Region: trmE; cd04164 426430008036 G1 box; other site 426430008037 GTP/Mg2+ binding site [chemical binding]; other site 426430008038 Switch I region; other site 426430008039 G2 box; other site 426430008040 Switch II region; other site 426430008041 G3 box; other site 426430008042 G4 box; other site 426430008043 G5 box; other site 426430008044 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 426430008045 ribonuclease P; Reviewed; Region: rnpA; PRK00499 426430008046 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399