-- dump date 20140620_074714 -- class Genbank::misc_feature -- table misc_feature_note -- id note 273036000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 273036000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 273036000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036000004 Walker A motif; other site 273036000005 ATP binding site [chemical binding]; other site 273036000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 273036000007 Walker B motif; other site 273036000008 arginine finger; other site 273036000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 273036000010 DnaA box-binding interface [nucleotide binding]; other site 273036000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 273036000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 273036000013 putative DNA binding surface [nucleotide binding]; other site 273036000014 dimer interface [polypeptide binding]; other site 273036000015 beta-clamp/clamp loader binding surface; other site 273036000016 beta-clamp/translesion DNA polymerase binding surface; other site 273036000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 273036000018 recF protein; Region: recf; TIGR00611 273036000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 273036000020 Walker A/P-loop; other site 273036000021 ATP binding site [chemical binding]; other site 273036000022 Q-loop/lid; other site 273036000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273036000024 ABC transporter signature motif; other site 273036000025 Walker B; other site 273036000026 D-loop; other site 273036000027 H-loop/switch region; other site 273036000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 273036000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036000030 Mg2+ binding site [ion binding]; other site 273036000031 G-X-G motif; other site 273036000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 273036000033 anchoring element; other site 273036000034 dimer interface [polypeptide binding]; other site 273036000035 ATP binding site [chemical binding]; other site 273036000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 273036000037 active site 273036000038 putative metal-binding site [ion binding]; other site 273036000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 273036000040 DNA gyrase subunit A; Validated; Region: PRK05560 273036000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 273036000042 CAP-like domain; other site 273036000043 active site 273036000044 primary dimer interface [polypeptide binding]; other site 273036000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273036000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273036000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273036000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273036000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273036000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273036000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 273036000052 putative substrate binding site [chemical binding]; other site 273036000053 putative ATP binding site [chemical binding]; other site 273036000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 273036000055 active sites [active] 273036000056 tetramer interface [polypeptide binding]; other site 273036000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 273036000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 273036000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 273036000060 dimer interface [polypeptide binding]; other site 273036000061 active site 273036000062 motif 1; other site 273036000063 motif 2; other site 273036000064 motif 3; other site 273036000065 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 273036000066 Predicted membrane protein [Function unknown]; Region: COG4392 273036000067 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 273036000068 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 273036000069 Predicted membrane protein [Function unknown]; Region: COG4241 273036000070 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 273036000071 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 273036000072 DHH family; Region: DHH; pfam01368 273036000073 DHHA1 domain; Region: DHHA1; pfam02272 273036000074 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 273036000075 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 273036000076 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 273036000077 replicative DNA helicase; Region: DnaB; TIGR00665 273036000078 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 273036000079 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 273036000080 Walker A motif; other site 273036000081 ATP binding site [chemical binding]; other site 273036000082 Walker B motif; other site 273036000083 DNA binding loops [nucleotide binding] 273036000084 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 273036000085 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 273036000086 GDP-binding site [chemical binding]; other site 273036000087 ACT binding site; other site 273036000088 IMP binding site; other site 273036000089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273036000090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273036000091 active site 273036000092 phosphorylation site [posttranslational modification] 273036000093 intermolecular recognition site; other site 273036000094 dimerization interface [polypeptide binding]; other site 273036000095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273036000096 DNA binding site [nucleotide binding] 273036000097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 273036000098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273036000099 dimerization interface [polypeptide binding]; other site 273036000100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273036000101 putative active site [active] 273036000102 heme pocket [chemical binding]; other site 273036000103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273036000104 dimer interface [polypeptide binding]; other site 273036000105 phosphorylation site [posttranslational modification] 273036000106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036000107 ATP binding site [chemical binding]; other site 273036000108 Mg2+ binding site [ion binding]; other site 273036000109 G-X-G motif; other site 273036000110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 273036000111 YycH protein; Region: YycH; pfam07435 273036000112 YycH protein; Region: YycI; cl02015 273036000113 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 273036000114 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 273036000115 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 273036000116 putative active site [active] 273036000117 putative metal binding site [ion binding]; other site 273036000118 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 273036000119 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 273036000120 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 273036000121 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 273036000122 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036000123 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 273036000124 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 273036000125 phosphate binding site [ion binding]; other site 273036000126 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 273036000127 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 273036000128 putative homodimer interface [polypeptide binding]; other site 273036000129 putative homotetramer interface [polypeptide binding]; other site 273036000130 putative metal binding site [ion binding]; other site 273036000131 putative homodimer-homodimer interface [polypeptide binding]; other site 273036000132 putative allosteric switch controlling residues; other site 273036000133 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 273036000134 active site residue [active] 273036000135 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 273036000136 CPxP motif; other site 273036000137 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 273036000138 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 273036000139 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 273036000140 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 273036000141 active site residue [active] 273036000142 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 273036000143 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 273036000144 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 273036000145 FMN binding site [chemical binding]; other site 273036000146 active site 273036000147 catalytic residues [active] 273036000148 substrate binding site [chemical binding]; other site 273036000149 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 273036000150 Methyltransferase domain; Region: Methyltransf_23; pfam13489 273036000151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036000152 S-adenosylmethionine binding site [chemical binding]; other site 273036000153 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 273036000154 active site 273036000155 catalytic site [active] 273036000156 putative metal binding site [ion binding]; other site 273036000157 probable lipoprotein 273036000158 Protein of unknown function, DUF576; Region: DUF576; pfam04507 273036000159 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 273036000160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273036000161 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 273036000162 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 273036000163 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 273036000164 metal binding site [ion binding]; metal-binding site 273036000165 dimer interface [polypeptide binding]; other site 273036000166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036000167 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273036000168 putative substrate translocation pore; other site 273036000169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036000170 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 273036000171 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 273036000172 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 273036000173 PhoU domain; Region: PhoU; pfam01895 273036000174 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 273036000175 EamA-like transporter family; Region: EamA; pfam00892 273036000176 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 273036000177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273036000178 DNA-binding site [nucleotide binding]; DNA binding site 273036000179 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273036000180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036000181 homodimer interface [polypeptide binding]; other site 273036000182 catalytic residue [active] 273036000183 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 273036000184 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 273036000185 L-lactate permease; Region: Lactate_perm; cl00701 273036000186 immunoglobulin G binding protein A precusor 273036000187 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 273036000188 Transcriptional regulators [Transcription]; Region: MarR; COG1846 273036000189 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 273036000190 Transcriptional regulators [Transcription]; Region: MarR; COG1846 273036000191 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 273036000192 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273036000193 ABC-ATPase subunit interface; other site 273036000194 dimer interface [polypeptide binding]; other site 273036000195 putative PBP binding regions; other site 273036000196 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 273036000197 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273036000198 ABC-ATPase subunit interface; other site 273036000199 dimer interface [polypeptide binding]; other site 273036000200 putative PBP binding regions; other site 273036000201 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 273036000202 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 273036000203 siderophore binding site; other site 273036000204 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 273036000205 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 273036000206 dimer interface [polypeptide binding]; other site 273036000207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036000208 catalytic residue [active] 273036000209 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 273036000210 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 273036000211 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 273036000212 IucA / IucC family; Region: IucA_IucC; pfam04183 273036000213 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 273036000214 drug efflux system protein MdtG; Provisional; Region: PRK09874 273036000215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036000216 putative substrate translocation pore; other site 273036000217 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 273036000218 IucA / IucC family; Region: IucA_IucC; pfam04183 273036000219 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 273036000220 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 273036000221 IucA / IucC family; Region: IucA_IucC; pfam04183 273036000222 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 273036000223 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 273036000224 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 273036000225 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 273036000226 dimer interface [polypeptide binding]; other site 273036000227 active site 273036000228 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273036000229 catalytic residues [active] 273036000230 substrate binding site [chemical binding]; other site 273036000231 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 273036000232 ParB-like nuclease domain; Region: ParBc; pfam02195 273036000233 hypothetical protein 273036000234 acetoin reductase; Validated; Region: PRK08643 273036000235 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 273036000236 NAD binding site [chemical binding]; other site 273036000237 homotetramer interface [polypeptide binding]; other site 273036000238 homodimer interface [polypeptide binding]; other site 273036000239 active site 273036000240 substrate binding site [chemical binding]; other site 273036000241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273036000242 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 273036000243 NAD(P) binding site [chemical binding]; other site 273036000244 active site 273036000245 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 273036000246 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 273036000247 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 273036000248 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 273036000249 putative ADP-binding pocket [chemical binding]; other site 273036000250 O-Antigen ligase; Region: Wzy_C; cl04850 273036000251 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 273036000252 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 273036000253 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 273036000254 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 273036000255 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 273036000256 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 273036000257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273036000258 DNA-binding site [nucleotide binding]; DNA binding site 273036000259 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 273036000260 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 273036000261 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273036000262 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 273036000263 intersubunit interface [polypeptide binding]; other site 273036000264 active site 273036000265 catalytic residue [active] 273036000266 phosphopentomutase; Provisional; Region: PRK05362 273036000267 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 273036000268 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 273036000269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036000270 dimer interface [polypeptide binding]; other site 273036000271 conserved gate region; other site 273036000272 ABC-ATPase subunit interface; other site 273036000273 phosphonate ABC transporter permease 273036000274 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 273036000275 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 273036000276 Walker A/P-loop; other site 273036000277 ATP binding site [chemical binding]; other site 273036000278 Q-loop/lid; other site 273036000279 ABC transporter signature motif; other site 273036000280 Walker B; other site 273036000281 D-loop; other site 273036000282 H-loop/switch region; other site 273036000283 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 273036000284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 273036000285 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 273036000286 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 273036000287 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 273036000288 active site 273036000289 metal binding site [ion binding]; metal-binding site 273036000290 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 273036000291 conserved hypothetical protein 273036000292 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 273036000293 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273036000294 non-specific DNA binding site [nucleotide binding]; other site 273036000295 salt bridge; other site 273036000296 sequence-specific DNA binding site [nucleotide binding]; other site 273036000297 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 273036000298 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 273036000299 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 273036000300 putative catalytic cysteine [active] 273036000301 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 273036000302 putative active site [active] 273036000303 metal binding site [ion binding]; metal-binding site 273036000304 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 273036000305 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 273036000306 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 273036000307 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 273036000308 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 273036000309 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 273036000310 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 273036000311 NAD(P) binding site [chemical binding]; other site 273036000312 homodimer interface [polypeptide binding]; other site 273036000313 substrate binding site [chemical binding]; other site 273036000314 active site 273036000315 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 273036000316 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 273036000317 NAD(P) binding site [chemical binding]; other site 273036000318 homodimer interface [polypeptide binding]; other site 273036000319 substrate binding site [chemical binding]; other site 273036000320 active site 273036000321 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 273036000322 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 273036000323 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 273036000324 putative NAD(P) binding site [chemical binding]; other site 273036000325 active site 273036000326 putative substrate binding site [chemical binding]; other site 273036000327 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 273036000328 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 273036000329 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 273036000330 active site 273036000331 homodimer interface [polypeptide binding]; other site 273036000332 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 273036000333 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 273036000334 trimer interface [polypeptide binding]; other site 273036000335 active site 273036000336 substrate binding site [chemical binding]; other site 273036000337 CoA binding site [chemical binding]; other site 273036000338 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 273036000339 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 273036000340 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 273036000341 Bacterial sugar transferase; Region: Bac_transf; pfam02397 273036000342 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 273036000343 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 273036000344 putative NAD(P) binding site [chemical binding]; other site 273036000345 active site 273036000346 putative substrate binding site [chemical binding]; other site 273036000347 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 273036000348 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 273036000349 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 273036000350 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 273036000351 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 273036000352 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 273036000353 active site 273036000354 homodimer interface [polypeptide binding]; other site 273036000355 conserved hypothetical protein 273036000356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 273036000357 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 273036000358 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 273036000359 NAD(P) binding site [chemical binding]; other site 273036000360 catalytic residues [active] 273036000361 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 273036000362 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 273036000363 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 273036000364 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 273036000365 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 273036000366 Walker A/P-loop; other site 273036000367 ATP binding site [chemical binding]; other site 273036000368 Q-loop/lid; other site 273036000369 ABC transporter signature motif; other site 273036000370 Walker B; other site 273036000371 D-loop; other site 273036000372 H-loop/switch region; other site 273036000373 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 273036000374 NMT1-like family; Region: NMT1_2; pfam13379 273036000375 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 273036000376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036000377 dimer interface [polypeptide binding]; other site 273036000378 conserved gate region; other site 273036000379 putative PBP binding loops; other site 273036000380 ABC-ATPase subunit interface; other site 273036000381 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 273036000382 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 273036000383 Uncharacterized conserved protein [Function unknown]; Region: COG5609 273036000384 formate dehydrogenase; Provisional; Region: PRK07574 273036000385 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 273036000386 dimerization interface [polypeptide binding]; other site 273036000387 ligand binding site [chemical binding]; other site 273036000388 NAD binding site [chemical binding]; other site 273036000389 catalytic site [active] 273036000390 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 273036000391 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 273036000392 acyl-activating enzyme (AAE) consensus motif; other site 273036000393 AMP binding site [chemical binding]; other site 273036000394 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 273036000395 Condensation domain; Region: Condensation; pfam00668 273036000396 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 273036000397 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 273036000398 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 273036000399 acyl-activating enzyme (AAE) consensus motif; other site 273036000400 AMP binding site [chemical binding]; other site 273036000401 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 273036000402 thioester reductase domain; Region: Thioester-redct; TIGR01746 273036000403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273036000404 NAD(P) binding site [chemical binding]; other site 273036000405 active site 273036000406 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 273036000407 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 273036000408 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 273036000409 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 273036000410 nucleotide binding site [chemical binding]; other site 273036000411 N-acetyl-L-glutamate binding site [chemical binding]; other site 273036000412 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 273036000413 heterotetramer interface [polypeptide binding]; other site 273036000414 active site pocket [active] 273036000415 cleavage site 273036000416 N-acetyl-gamma-glutamyl-phosphate reductase 273036000417 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 273036000418 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 273036000419 inhibitor-cofactor binding pocket; inhibition site 273036000420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036000421 catalytic residue [active] 273036000422 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 273036000423 Isochorismatase family; Region: Isochorismatase; pfam00857 273036000424 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 273036000425 catalytic triad [active] 273036000426 conserved cis-peptide bond; other site 273036000427 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 273036000428 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 273036000429 dimer interface [polypeptide binding]; other site 273036000430 PYR/PP interface [polypeptide binding]; other site 273036000431 TPP binding site [chemical binding]; other site 273036000432 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 273036000433 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 273036000434 TPP-binding site [chemical binding]; other site 273036000435 dimer interface [polypeptide binding]; other site 273036000436 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 273036000437 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 273036000438 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 273036000439 active site turn [active] 273036000440 phosphorylation site [posttranslational modification] 273036000441 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 273036000442 HPr interaction site; other site 273036000443 glycerol kinase (GK) interaction site [polypeptide binding]; other site 273036000444 active site 273036000445 phosphorylation site [posttranslational modification] 273036000446 Uncharacterized conserved protein [Function unknown]; Region: COG3589 273036000447 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 273036000448 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 273036000449 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 273036000450 putative active site [active] 273036000451 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 273036000452 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 273036000453 active site turn [active] 273036000454 phosphorylation site [posttranslational modification] 273036000455 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 273036000456 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 273036000457 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 273036000458 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273036000459 putative active site [active] 273036000460 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 273036000461 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 273036000462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273036000463 ATP binding site [chemical binding]; other site 273036000464 putative Mg++ binding site [ion binding]; other site 273036000465 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 273036000466 HlyD family secretion protein; Region: HlyD_3; pfam13437 273036000467 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 273036000468 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 273036000469 Walker A/P-loop; other site 273036000470 ATP binding site [chemical binding]; other site 273036000471 Q-loop/lid; other site 273036000472 ABC transporter signature motif; other site 273036000473 Walker B; other site 273036000474 D-loop; other site 273036000475 H-loop/switch region; other site 273036000476 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 273036000477 FtsX-like permease family; Region: FtsX; pfam02687 273036000478 Integral membrane protein DUF95; Region: DUF95; cl00572 273036000479 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 273036000480 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 273036000481 Walker A/P-loop; other site 273036000482 ATP binding site [chemical binding]; other site 273036000483 Q-loop/lid; other site 273036000484 ABC transporter signature motif; other site 273036000485 Walker B; other site 273036000486 D-loop; other site 273036000487 H-loop/switch region; other site 273036000488 oligopeptide transport ATP-binding protein 273036000489 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 273036000490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036000491 dimer interface [polypeptide binding]; other site 273036000492 conserved gate region; other site 273036000493 putative PBP binding loops; other site 273036000494 ABC-ATPase subunit interface; other site 273036000495 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 273036000496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036000497 dimer interface [polypeptide binding]; other site 273036000498 conserved gate region; other site 273036000499 ABC-ATPase subunit interface; other site 273036000500 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 273036000501 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 273036000502 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 273036000503 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 273036000504 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 273036000505 azoreductase; Reviewed; Region: PRK00170 273036000506 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 273036000507 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 273036000508 Peptidase family M23; Region: Peptidase_M23; pfam01551 273036000509 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 273036000510 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 273036000511 Walker A/P-loop; other site 273036000512 ATP binding site [chemical binding]; other site 273036000513 Q-loop/lid; other site 273036000514 ABC transporter signature motif; other site 273036000515 Walker B; other site 273036000516 D-loop; other site 273036000517 H-loop/switch region; other site 273036000518 TOBE domain; Region: TOBE; pfam03459 273036000519 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 273036000520 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 273036000521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036000522 dimer interface [polypeptide binding]; other site 273036000523 conserved gate region; other site 273036000524 ABC-ATPase subunit interface; other site 273036000525 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 273036000526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036000527 dimer interface [polypeptide binding]; other site 273036000528 conserved gate region; other site 273036000529 putative PBP binding loops; other site 273036000530 ABC-ATPase subunit interface; other site 273036000531 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 273036000532 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 273036000533 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 273036000534 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 273036000535 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 273036000536 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 273036000537 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 273036000538 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 273036000539 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 273036000540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 273036000541 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 273036000542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036000543 putative substrate translocation pore; other site 273036000544 Response regulator receiver domain; Region: Response_reg; pfam00072 273036000545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273036000546 active site 273036000547 phosphorylation site [posttranslational modification] 273036000548 intermolecular recognition site; other site 273036000549 dimerization interface [polypeptide binding]; other site 273036000550 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273036000551 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 273036000552 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 273036000553 Histidine kinase; Region: His_kinase; pfam06580 273036000554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036000555 ATP binding site [chemical binding]; other site 273036000556 Mg2+ binding site [ion binding]; other site 273036000557 G-X-G motif; other site 273036000558 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 273036000559 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 273036000560 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 273036000561 Pyruvate formate lyase 1; Region: PFL1; cd01678 273036000562 coenzyme A binding site [chemical binding]; other site 273036000563 active site 273036000564 catalytic residues [active] 273036000565 glycine loop; other site 273036000566 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 273036000567 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273036000568 FeS/SAM binding site; other site 273036000569 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 273036000570 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 273036000571 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 273036000572 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 273036000573 putative active site [active] 273036000574 catalytic site [active] 273036000575 putative metal binding site [ion binding]; other site 273036000576 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 273036000577 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 273036000578 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 273036000579 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 273036000580 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 273036000581 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 273036000582 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 273036000583 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 273036000584 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 273036000585 dimer interface [polypeptide binding]; other site 273036000586 active site 273036000587 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 273036000588 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 273036000589 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 273036000590 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 273036000591 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 273036000592 substrate binding site [chemical binding]; other site 273036000593 oxyanion hole (OAH) forming residues; other site 273036000594 trimer interface [polypeptide binding]; other site 273036000595 glutaryl or acyl-CoA dehydrogenase 273036000596 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 273036000597 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 273036000598 acyl-activating enzyme (AAE) consensus motif; other site 273036000599 AMP binding site [chemical binding]; other site 273036000600 active site 273036000601 CoA binding site [chemical binding]; other site 273036000602 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 273036000603 Coenzyme A transferase; Region: CoA_trans; smart00882 273036000604 Coenzyme A transferase; Region: CoA_trans; cl17247 273036000605 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 273036000606 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 273036000607 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 273036000608 Uncharacterized conserved protein [Function unknown]; Region: COG3189 273036000609 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 273036000610 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 273036000611 heme-binding site [chemical binding]; other site 273036000612 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 273036000613 FAD binding pocket [chemical binding]; other site 273036000614 FAD binding motif [chemical binding]; other site 273036000615 phosphate binding motif [ion binding]; other site 273036000616 beta-alpha-beta structure motif; other site 273036000617 NAD binding pocket [chemical binding]; other site 273036000618 Heme binding pocket [chemical binding]; other site 273036000619 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 273036000620 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 273036000621 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273036000622 NAD binding site [chemical binding]; other site 273036000623 dimer interface [polypeptide binding]; other site 273036000624 substrate binding site [chemical binding]; other site 273036000625 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 273036000626 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 273036000627 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 273036000628 active site turn [active] 273036000629 phosphorylation site [posttranslational modification] 273036000630 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 273036000631 active site 273036000632 tetramer interface [polypeptide binding]; other site 273036000633 probable transcriptional regulator 273036000634 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273036000635 active site 273036000636 phosphorylation site [posttranslational modification] 273036000637 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 273036000638 active site 273036000639 P-loop; other site 273036000640 phosphorylation site [posttranslational modification] 273036000641 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 273036000642 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 273036000643 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 273036000644 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 273036000645 putative NAD(P) binding site [chemical binding]; other site 273036000646 catalytic Zn binding site [ion binding]; other site 273036000647 structural Zn binding site [ion binding]; other site 273036000648 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 273036000649 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 273036000650 putative NAD(P) binding site [chemical binding]; other site 273036000651 catalytic Zn binding site [ion binding]; other site 273036000652 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 273036000653 substrate binding site; other site 273036000654 dimer interface; other site 273036000655 probable zinc-binding dehydrogenase 273036000656 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 273036000657 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 273036000658 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 273036000659 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 273036000660 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 273036000661 substrate binding site; other site 273036000662 dimer interface; other site 273036000663 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 273036000664 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 273036000665 putative NAD(P) binding site [chemical binding]; other site 273036000666 putative catalytic Zn binding site [ion binding]; other site 273036000667 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 273036000668 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 273036000669 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 273036000670 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 273036000671 active site 273036000672 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 273036000673 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 273036000674 Hemerythrin-like domain; Region: Hr-like; cd12108 273036000675 Fe binding site [ion binding]; other site 273036000676 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 273036000677 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 273036000678 Histidine kinase; Region: His_kinase; pfam06580 273036000679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036000680 Mg2+ binding site [ion binding]; other site 273036000681 G-X-G motif; other site 273036000682 two-component response regulator; Provisional; Region: PRK14084 273036000683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273036000684 active site 273036000685 phosphorylation site [posttranslational modification] 273036000686 intermolecular recognition site; other site 273036000687 dimerization interface [polypeptide binding]; other site 273036000688 LytTr DNA-binding domain; Region: LytTR; pfam04397 273036000689 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 273036000690 antiholin-like protein LrgB; Provisional; Region: PRK04288 273036000691 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 273036000692 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273036000693 DNA-binding site [nucleotide binding]; DNA binding site 273036000694 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 273036000695 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 273036000696 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 273036000697 HPr interaction site; other site 273036000698 glycerol kinase (GK) interaction site [polypeptide binding]; other site 273036000699 active site 273036000700 phosphorylation site [posttranslational modification] 273036000701 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 273036000702 beta-galactosidase; Region: BGL; TIGR03356 273036000703 Methyltransferase domain; Region: Methyltransf_31; pfam13847 273036000704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036000705 S-adenosylmethionine binding site [chemical binding]; other site 273036000706 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 273036000707 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 273036000708 substrate binding site [chemical binding]; other site 273036000709 dimer interface [polypeptide binding]; other site 273036000710 ATP binding site [chemical binding]; other site 273036000711 D-ribose pyranase; Provisional; Region: PRK11797 273036000712 Sugar transport protein; Region: Sugar_transport; pfam06800 273036000713 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273036000714 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273036000715 DNA binding site [nucleotide binding] 273036000716 domain linker motif; other site 273036000717 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 273036000718 dimerization interface [polypeptide binding]; other site 273036000719 ligand binding site [chemical binding]; other site 273036000720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036000721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036000722 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 273036000723 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 273036000724 active site 273036000725 Surface antigen [General function prediction only]; Region: COG3942 273036000726 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 273036000727 Peptidase family M23; Region: Peptidase_M23; pfam01551 273036000728 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 273036000729 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 273036000730 Walker A/P-loop; other site 273036000731 ATP binding site [chemical binding]; other site 273036000732 Q-loop/lid; other site 273036000733 ABC transporter signature motif; other site 273036000734 Walker B; other site 273036000735 D-loop; other site 273036000736 H-loop/switch region; other site 273036000737 probable autolysin precursor 273036000738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 273036000739 Predicted membrane protein [Function unknown]; Region: COG1511 273036000740 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 273036000741 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 273036000742 probable membrane protein 273036000743 Uncharacterized small protein [Function unknown]; Region: COG5417 273036000744 Predicted membrane protein [Function unknown]; Region: COG4499 273036000745 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 273036000746 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 273036000747 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 273036000748 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 273036000749 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 273036000750 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 273036000751 hypothetical protein 273036000752 Protein of unknown function, DUF600; Region: DUF600; cl04640 273036000753 Protein of unknown function, DUF600; Region: DUF600; cl04640 273036000754 Protein of unknown function, DUF600; Region: DUF600; cl04640 273036000755 Protein of unknown function, DUF600; Region: DUF600; cl04640 273036000756 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 273036000757 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 273036000758 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 273036000759 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 273036000760 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 273036000761 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 273036000762 FtsX-like permease family; Region: FtsX; pfam02687 273036000763 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 273036000764 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 273036000765 Walker A/P-loop; other site 273036000766 ATP binding site [chemical binding]; other site 273036000767 Q-loop/lid; other site 273036000768 ABC transporter signature motif; other site 273036000769 Walker B; other site 273036000770 D-loop; other site 273036000771 H-loop/switch region; other site 273036000772 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 273036000773 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 273036000774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273036000775 non-specific DNA binding site [nucleotide binding]; other site 273036000776 salt bridge; other site 273036000777 sequence-specific DNA binding site [nucleotide binding]; other site 273036000778 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 273036000779 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 273036000780 substrate binding site [chemical binding]; other site 273036000781 ATP binding site [chemical binding]; other site 273036000782 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 273036000783 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 273036000784 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 273036000785 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 273036000786 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 273036000787 putative transporter; Provisional; Region: PRK10484 273036000788 Na binding site [ion binding]; other site 273036000789 N-acetylneuraminate lyase; Provisional; Region: PRK04147 273036000790 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 273036000791 inhibitor site; inhibition site 273036000792 active site 273036000793 dimer interface [polypeptide binding]; other site 273036000794 catalytic residue [active] 273036000795 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 273036000796 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 273036000797 nucleotide binding site [chemical binding]; other site 273036000798 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 273036000799 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 273036000800 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273036000801 putative active site [active] 273036000802 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 273036000803 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 273036000804 putative active site cavity [active] 273036000805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 273036000806 Nucleoside recognition; Region: Gate; pfam07670 273036000807 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 273036000808 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 273036000809 PGAP1-like protein; Region: PGAP1; pfam07819 273036000810 possible integrated phage with similarity to bacteriophage phi12 273036000811 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 273036000812 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 273036000813 Int/Topo IB signature motif; other site 273036000814 CAAX protease self-immunity; Region: Abi; pfam02517 273036000815 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 273036000816 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 273036000817 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 273036000818 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 273036000819 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 273036000820 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 273036000821 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 273036000822 holin, SPP1 family; Region: holin_SPP1; TIGR01592 273036000823 phage-related amidase 273036000824 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 273036000825 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 273036000826 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 273036000827 putative active site [active] 273036000828 putative FMN binding site [chemical binding]; other site 273036000829 putative substrate binding site [chemical binding]; other site 273036000830 putative catalytic residue [active] 273036000831 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 273036000832 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 273036000833 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 273036000834 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 273036000835 lipoyl attachment site [posttranslational modification]; other site 273036000836 Replication protein C N-terminal domain; Region: RP-C; pfam03428 273036000837 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 273036000838 putative ADP-ribose binding site [chemical binding]; other site 273036000839 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 273036000840 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 273036000841 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 273036000842 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 273036000843 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 273036000844 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 273036000845 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 273036000846 active site 273036000847 P-loop; other site 273036000848 phosphorylation site [posttranslational modification] 273036000849 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273036000850 active site 273036000851 phosphorylation site [posttranslational modification] 273036000852 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 273036000853 HTH domain; Region: HTH_11; pfam08279 273036000854 HTH domain; Region: HTH_11; pfam08279 273036000855 PRD domain; Region: PRD; pfam00874 273036000856 PRD domain; Region: PRD; pfam00874 273036000857 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 273036000858 active site 273036000859 P-loop; other site 273036000860 phosphorylation site [posttranslational modification] 273036000861 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273036000862 active site 273036000863 phosphorylation site [posttranslational modification] 273036000864 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 273036000865 MarR family; Region: MarR_2; pfam12802 273036000866 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 273036000867 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 273036000868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 273036000869 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 273036000870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036000871 putative substrate translocation pore; other site 273036000872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036000873 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 273036000874 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 273036000875 Zn binding site [ion binding]; other site 273036000876 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 273036000877 Zn binding site [ion binding]; other site 273036000878 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 273036000879 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 273036000880 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 273036000881 Predicted flavoprotein [General function prediction only]; Region: COG0431 273036000882 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 273036000883 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 273036000884 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 273036000885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 273036000886 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 273036000887 Imelysin; Region: Peptidase_M75; pfam09375 273036000888 probable membrane protein 273036000889 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 273036000890 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 273036000891 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 273036000892 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 273036000893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273036000894 non-specific DNA binding site [nucleotide binding]; other site 273036000895 salt bridge; other site 273036000896 sequence-specific DNA binding site [nucleotide binding]; other site 273036000897 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 273036000898 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 273036000899 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 273036000900 Walker A/P-loop; other site 273036000901 ATP binding site [chemical binding]; other site 273036000902 Q-loop/lid; other site 273036000903 ABC transporter signature motif; other site 273036000904 Walker B; other site 273036000905 D-loop; other site 273036000906 H-loop/switch region; other site 273036000907 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 273036000908 Predicted membrane protein [Function unknown]; Region: COG4292 273036000909 putative acyltransferase; Provisional; Region: PRK05790 273036000910 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 273036000911 dimer interface [polypeptide binding]; other site 273036000912 active site 273036000913 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 273036000914 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 273036000915 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 273036000916 THF binding site; other site 273036000917 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 273036000918 substrate binding site [chemical binding]; other site 273036000919 THF binding site; other site 273036000920 zinc-binding site [ion binding]; other site 273036000921 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 273036000922 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 273036000923 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 273036000924 FAD binding site [chemical binding]; other site 273036000925 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 273036000926 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 273036000927 homodimer interface [polypeptide binding]; other site 273036000928 substrate-cofactor binding pocket; other site 273036000929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036000930 catalytic residue [active] 273036000931 cystathionine gamma-synthase; Reviewed; Region: PRK08247 273036000932 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 273036000933 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273036000934 catalytic residue [active] 273036000935 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 273036000936 ParB-like nuclease domain; Region: ParB; smart00470 273036000937 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 273036000938 Mechanosensitive ion channel; Region: MS_channel; pfam00924 273036000939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 273036000940 GTP-binding protein YchF; Reviewed; Region: PRK09601 273036000941 YchF GTPase; Region: YchF; cd01900 273036000942 G1 box; other site 273036000943 GTP/Mg2+ binding site [chemical binding]; other site 273036000944 Switch I region; other site 273036000945 G2 box; other site 273036000946 Switch II region; other site 273036000947 G3 box; other site 273036000948 G4 box; other site 273036000949 G5 box; other site 273036000950 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 273036000951 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 273036000952 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 273036000953 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 273036000954 dimer interface [polypeptide binding]; other site 273036000955 ssDNA binding site [nucleotide binding]; other site 273036000956 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273036000957 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 273036000958 Abi-like protein; Region: Abi_2; pfam07751 273036000959 integrase fragment 273036000960 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036000961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 273036000962 Predicted membrane protein [Function unknown]; Region: COG3212 273036000963 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 273036000964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 273036000965 non-specific DNA binding site [nucleotide binding]; other site 273036000966 salt bridge; other site 273036000967 sequence-specific DNA binding site [nucleotide binding]; other site 273036000968 Predicted membrane protein [Function unknown]; Region: COG2261 273036000969 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 273036000970 catalytic core [active] 273036000971 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 273036000972 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 273036000973 catalytic residue [active] 273036000974 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 273036000975 catalytic residues [active] 273036000976 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273036000977 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273036000978 peroxiredoxin; Region: AhpC; TIGR03137 273036000979 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 273036000980 dimer interface [polypeptide binding]; other site 273036000981 decamer (pentamer of dimers) interface [polypeptide binding]; other site 273036000982 catalytic triad [active] 273036000983 peroxidatic and resolving cysteines [active] 273036000984 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 273036000985 dimer interface [polypeptide binding]; other site 273036000986 FMN binding site [chemical binding]; other site 273036000987 NADPH bind site [chemical binding]; other site 273036000988 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 273036000989 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 273036000990 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 273036000991 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273036000992 active site 273036000993 xanthine permease; Region: pbuX; TIGR03173 273036000994 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 273036000995 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 273036000996 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 273036000997 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 273036000998 active site 273036000999 GMP synthase; Reviewed; Region: guaA; PRK00074 273036001000 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 273036001001 AMP/PPi binding site [chemical binding]; other site 273036001002 candidate oxyanion hole; other site 273036001003 catalytic triad [active] 273036001004 potential glutamine specificity residues [chemical binding]; other site 273036001005 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 273036001006 ATP Binding subdomain [chemical binding]; other site 273036001007 Ligand Binding sites [chemical binding]; other site 273036001008 Dimerization subdomain; other site 273036001009 genomic island repeat SaPIbovR1 273036001010 pathogenicity island SaPIbov 273036001011 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 273036001012 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 273036001013 Int/Topo IB signature motif; other site 273036001014 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 273036001015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273036001016 non-specific DNA binding site [nucleotide binding]; other site 273036001017 salt bridge; other site 273036001018 sequence-specific DNA binding site [nucleotide binding]; other site 273036001019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273036001020 non-specific DNA binding site [nucleotide binding]; other site 273036001021 salt bridge; other site 273036001022 sequence-specific DNA binding site [nucleotide binding]; other site 273036001023 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 273036001024 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 273036001025 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 273036001026 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 273036001027 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 273036001028 superantigen-like protein; Reviewed; Region: PRK13038 273036001029 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 273036001030 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036001031 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 273036001032 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036001033 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 273036001034 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036001035 genomic island repeat SaPIbovR2 273036001036 hypothetical protein 273036001037 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 273036001038 Protein of unknown function (DUF523); Region: DUF523; pfam04463 273036001039 Predicted membrane protein [Function unknown]; Region: COG3759 273036001040 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 273036001041 NADH(P)-binding; Region: NAD_binding_10; pfam13460 273036001042 NADP binding site [chemical binding]; other site 273036001043 superantigen-like protein; Reviewed; Region: PRK13037 273036001044 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 273036001045 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036001046 superantigen-like protein; Reviewed; Region: PRK13041 273036001047 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 273036001048 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036001049 superantigen-like protein; Reviewed; Region: PRK13335 273036001050 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 273036001051 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036001052 superantigen-like protein 5; Reviewed; Region: PRK13035 273036001053 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 273036001054 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036001055 superantigen-like protein 7; Reviewed; Region: PRK13346 273036001056 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 273036001057 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036001058 superantigen-like protein; Reviewed; Region: PRK13039 273036001059 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 273036001060 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036001061 superantigen-like protein; Reviewed; Region: PRK13345 273036001062 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 273036001063 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036001064 superantigen-like protein; Reviewed; Region: PRK13038 273036001065 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 273036001066 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036001067 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 273036001068 HsdM N-terminal domain; Region: HsdM_N; pfam12161 273036001069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036001070 S-adenosylmethionine binding site [chemical binding]; other site 273036001071 probable type I site-specific deoxyribonuclease subunit 273036001072 superantigen-like protein; Reviewed; Region: PRK13036 273036001073 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 273036001074 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036001075 Protein of unknown function, DUF576; Region: DUF576; pfam04507 273036001076 Protein of unknown function, DUF576; Region: DUF576; cl04553 273036001077 Protein of unknown function, DUF576; Region: DUF576; cl04553 273036001078 Protein of unknown function, DUF576; Region: DUF576; pfam04507 273036001079 Protein of unknown function, DUF576; Region: DUF576; pfam04507 273036001080 Protein of unknown function, DUF576; Region: DUF576; pfam04507 273036001081 Protein of unknown function, DUF576; Region: DUF576; pfam04507 273036001082 Protein of unknown function, DUF576; Region: DUF576; pfam04507 273036001083 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 273036001084 nucleophilic elbow; other site 273036001085 catalytic triad; other site 273036001086 hypothetical protein 273036001087 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 273036001088 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 273036001089 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 273036001090 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 273036001091 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 273036001092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 273036001093 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 273036001094 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 273036001095 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 273036001096 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 273036001097 active site 273036001098 Esterase/lipase [General function prediction only]; Region: COG1647 273036001099 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 273036001100 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 273036001101 Na2 binding site [ion binding]; other site 273036001102 putative substrate binding site 1 [chemical binding]; other site 273036001103 Na binding site 1 [ion binding]; other site 273036001104 putative substrate binding site 2 [chemical binding]; other site 273036001105 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 273036001106 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 273036001107 dimer interface [polypeptide binding]; other site 273036001108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036001109 catalytic residue [active] 273036001110 cystathionine beta-lyase; Provisional; Region: PRK07671 273036001111 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 273036001112 homodimer interface [polypeptide binding]; other site 273036001113 substrate-cofactor binding pocket; other site 273036001114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036001115 catalytic residue [active] 273036001116 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 273036001117 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 273036001118 Walker A/P-loop; other site 273036001119 ATP binding site [chemical binding]; other site 273036001120 Q-loop/lid; other site 273036001121 ABC transporter signature motif; other site 273036001122 Walker B; other site 273036001123 D-loop; other site 273036001124 H-loop/switch region; other site 273036001125 NIL domain; Region: NIL; pfam09383 273036001126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036001127 dimer interface [polypeptide binding]; other site 273036001128 conserved gate region; other site 273036001129 ABC-ATPase subunit interface; other site 273036001130 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 273036001131 LysM domain; Region: LysM; pfam01476 273036001132 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 273036001133 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 273036001134 Surface antigen [General function prediction only]; Region: COG3942 273036001135 CHAP domain; Region: CHAP; pfam05257 273036001136 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 273036001137 nudix motif; other site 273036001138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036001139 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 273036001140 Coenzyme A binding pocket [chemical binding]; other site 273036001141 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 273036001142 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 273036001143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273036001144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273036001145 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 273036001146 dimerization interface [polypeptide binding]; other site 273036001147 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 273036001148 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 273036001149 active site 273036001150 dimer interface [polypeptide binding]; other site 273036001151 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 273036001152 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 273036001153 active site 273036001154 FMN binding site [chemical binding]; other site 273036001155 substrate binding site [chemical binding]; other site 273036001156 3Fe-4S cluster binding site [ion binding]; other site 273036001157 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 273036001158 domain interface; other site 273036001159 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 273036001160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 273036001161 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 273036001162 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 273036001163 active site turn [active] 273036001164 phosphorylation site [posttranslational modification] 273036001165 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 273036001166 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 273036001167 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 273036001168 Ca binding site [ion binding]; other site 273036001169 active site 273036001170 catalytic site [active] 273036001171 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 273036001172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273036001173 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 273036001174 DNA-binding site [nucleotide binding]; DNA binding site 273036001175 UTRA domain; Region: UTRA; pfam07702 273036001176 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 273036001177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036001178 Coenzyme A binding pocket [chemical binding]; other site 273036001179 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 273036001180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036001181 Walker A motif; other site 273036001182 ATP binding site [chemical binding]; other site 273036001183 Walker B motif; other site 273036001184 arginine finger; other site 273036001185 hypothetical protein; Validated; Region: PRK00153 273036001186 recombination protein RecR; Reviewed; Region: recR; PRK00076 273036001187 RecR protein; Region: RecR; pfam02132 273036001188 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 273036001189 putative active site [active] 273036001190 putative metal-binding site [ion binding]; other site 273036001191 tetramer interface [polypeptide binding]; other site 273036001192 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 273036001193 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 273036001194 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273036001195 catalytic residue [active] 273036001196 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 273036001197 thymidylate kinase; Validated; Region: tmk; PRK00698 273036001198 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 273036001199 TMP-binding site; other site 273036001200 ATP-binding site [chemical binding]; other site 273036001201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 273036001202 DNA polymerase III subunit delta'; Validated; Region: PRK08058 273036001203 DNA polymerase III subunit delta'; Validated; Region: PRK08485 273036001204 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 273036001205 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 273036001206 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 273036001207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036001208 S-adenosylmethionine binding site [chemical binding]; other site 273036001209 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 273036001210 GIY-YIG motif/motif A; other site 273036001211 putative active site [active] 273036001212 putative metal binding site [ion binding]; other site 273036001213 Predicted methyltransferases [General function prediction only]; Region: COG0313 273036001214 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 273036001215 putative SAM binding site [chemical binding]; other site 273036001216 putative homodimer interface [polypeptide binding]; other site 273036001217 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 273036001218 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 273036001219 active site 273036001220 HIGH motif; other site 273036001221 KMSKS motif; other site 273036001222 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 273036001223 tRNA binding surface [nucleotide binding]; other site 273036001224 anticodon binding site; other site 273036001225 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 273036001226 dimer interface [polypeptide binding]; other site 273036001227 putative tRNA-binding site [nucleotide binding]; other site 273036001228 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 273036001229 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 273036001230 active site 273036001231 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 273036001232 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 273036001233 putative active site [active] 273036001234 putative metal binding site [ion binding]; other site 273036001235 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 273036001236 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 273036001237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036001238 S-adenosylmethionine binding site [chemical binding]; other site 273036001239 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 273036001240 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 273036001241 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 273036001242 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 273036001243 pur operon repressor; Provisional; Region: PRK09213 273036001244 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 273036001245 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273036001246 active site 273036001247 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 273036001248 homotrimer interaction site [polypeptide binding]; other site 273036001249 putative active site [active] 273036001250 regulatory protein SpoVG; Reviewed; Region: PRK13259 273036001251 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 273036001252 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 273036001253 Substrate binding site; other site 273036001254 Mg++ binding site; other site 273036001255 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 273036001256 active site 273036001257 substrate binding site [chemical binding]; other site 273036001258 CoA binding site [chemical binding]; other site 273036001259 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 273036001260 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 273036001261 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273036001262 active site 273036001263 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 273036001264 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 273036001265 5S rRNA interface [nucleotide binding]; other site 273036001266 CTC domain interface [polypeptide binding]; other site 273036001267 L16 interface [polypeptide binding]; other site 273036001268 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 273036001269 putative active site [active] 273036001270 catalytic residue [active] 273036001271 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 273036001272 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 273036001273 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273036001274 ATP binding site [chemical binding]; other site 273036001275 putative Mg++ binding site [ion binding]; other site 273036001276 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273036001277 nucleotide binding region [chemical binding]; other site 273036001278 ATP-binding site [chemical binding]; other site 273036001279 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 273036001280 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 273036001281 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 273036001282 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 273036001283 putative SAM binding site [chemical binding]; other site 273036001284 putative homodimer interface [polypeptide binding]; other site 273036001285 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 273036001286 homodimer interface [polypeptide binding]; other site 273036001287 metal binding site [ion binding]; metal-binding site 273036001288 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273036001289 RNA binding surface [nucleotide binding]; other site 273036001290 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 273036001291 Septum formation initiator; Region: DivIC; pfam04977 273036001292 hypothetical protein; Provisional; Region: PRK08582 273036001293 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 273036001294 RNA binding site [nucleotide binding]; other site 273036001295 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 273036001296 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 273036001297 Ligand Binding Site [chemical binding]; other site 273036001298 TilS substrate C-terminal domain; Region: TilS_C; smart00977 273036001299 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 273036001300 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273036001301 active site 273036001302 FtsH Extracellular; Region: FtsH_ext; pfam06480 273036001303 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 273036001304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036001305 Walker A motif; other site 273036001306 ATP binding site [chemical binding]; other site 273036001307 Walker B motif; other site 273036001308 arginine finger; other site 273036001309 Peptidase family M41; Region: Peptidase_M41; pfam01434 273036001310 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 273036001311 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 273036001312 dimerization interface [polypeptide binding]; other site 273036001313 domain crossover interface; other site 273036001314 redox-dependent activation switch; other site 273036001315 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 273036001316 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 273036001317 dimer interface [polypeptide binding]; other site 273036001318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036001319 catalytic residue [active] 273036001320 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 273036001321 dihydropteroate synthase; Region: DHPS; TIGR01496 273036001322 substrate binding pocket [chemical binding]; other site 273036001323 dimer interface [polypeptide binding]; other site 273036001324 inhibitor binding site; inhibition site 273036001325 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 273036001326 homooctamer interface [polypeptide binding]; other site 273036001327 active site 273036001328 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 273036001329 catalytic center binding site [active] 273036001330 ATP binding site [chemical binding]; other site 273036001331 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 273036001332 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 273036001333 dimer interface [polypeptide binding]; other site 273036001334 putative anticodon binding site; other site 273036001335 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 273036001336 motif 1; other site 273036001337 active site 273036001338 motif 2; other site 273036001339 motif 3; other site 273036001340 transposase 273036001341 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 273036001342 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273036001343 DNA-binding site [nucleotide binding]; DNA binding site 273036001344 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273036001345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036001346 homodimer interface [polypeptide binding]; other site 273036001347 catalytic residue [active] 273036001348 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 273036001349 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 273036001350 active site 273036001351 multimer interface [polypeptide binding]; other site 273036001352 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 273036001353 predicted active site [active] 273036001354 catalytic triad [active] 273036001355 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 273036001356 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 273036001357 Nucleoside recognition; Region: Gate; pfam07670 273036001358 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 273036001359 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 273036001360 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 273036001361 UvrB/uvrC motif; Region: UVR; pfam02151 273036001362 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 273036001363 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 273036001364 ADP binding site [chemical binding]; other site 273036001365 phosphagen binding site; other site 273036001366 substrate specificity loop; other site 273036001367 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 273036001368 Clp amino terminal domain; Region: Clp_N; pfam02861 273036001369 Clp amino terminal domain; Region: Clp_N; pfam02861 273036001370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036001371 Walker A motif; other site 273036001372 ATP binding site [chemical binding]; other site 273036001373 Walker B motif; other site 273036001374 arginine finger; other site 273036001375 UvrB/uvrC motif; Region: UVR; pfam02151 273036001376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036001377 Walker A motif; other site 273036001378 ATP binding site [chemical binding]; other site 273036001379 Walker B motif; other site 273036001380 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 273036001381 DNA repair protein RadA; Provisional; Region: PRK11823 273036001382 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 273036001383 Walker A motif/ATP binding site; other site 273036001384 ATP binding site [chemical binding]; other site 273036001385 Walker B motif; other site 273036001386 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 273036001387 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 273036001388 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 273036001389 putative active site [active] 273036001390 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 273036001391 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 273036001392 active site 273036001393 HIGH motif; other site 273036001394 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 273036001395 active site 273036001396 KMSKS motif; other site 273036001397 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 273036001398 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 273036001399 trimer interface [polypeptide binding]; other site 273036001400 active site 273036001401 substrate binding site [chemical binding]; other site 273036001402 CoA binding site [chemical binding]; other site 273036001403 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 273036001404 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 273036001405 active site 273036001406 HIGH motif; other site 273036001407 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 273036001408 KMSKS motif; other site 273036001409 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 273036001410 tRNA binding surface [nucleotide binding]; other site 273036001411 anticodon binding site; other site 273036001412 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 273036001413 active site 273036001414 dimerization interface [polypeptide binding]; other site 273036001415 metal binding site [ion binding]; metal-binding site 273036001416 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 273036001417 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 273036001418 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 273036001419 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 273036001420 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 273036001421 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273036001422 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 273036001423 DNA binding residues [nucleotide binding] 273036001424 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 273036001425 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 273036001426 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 273036001427 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 273036001428 putative homodimer interface [polypeptide binding]; other site 273036001429 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 273036001430 heterodimer interface [polypeptide binding]; other site 273036001431 homodimer interface [polypeptide binding]; other site 273036001432 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 273036001433 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 273036001434 23S rRNA interface [nucleotide binding]; other site 273036001435 L7/L12 interface [polypeptide binding]; other site 273036001436 putative thiostrepton binding site; other site 273036001437 L25 interface [polypeptide binding]; other site 273036001438 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 273036001439 mRNA/rRNA interface [nucleotide binding]; other site 273036001440 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 273036001441 23S rRNA interface [nucleotide binding]; other site 273036001442 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 273036001443 presumably nonfunctional 50S ribosomal protein L7/L12; contains an internal stop codon 273036001444 Methyltransferase domain; Region: Methyltransf_31; pfam13847 273036001445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036001446 S-adenosylmethionine binding site [chemical binding]; other site 273036001447 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 273036001448 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 273036001449 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 273036001450 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 273036001451 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 273036001452 RPB10 interaction site [polypeptide binding]; other site 273036001453 RPB1 interaction site [polypeptide binding]; other site 273036001454 RPB11 interaction site [polypeptide binding]; other site 273036001455 RPB3 interaction site [polypeptide binding]; other site 273036001456 RPB12 interaction site [polypeptide binding]; other site 273036001457 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 273036001458 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 273036001459 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 273036001460 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 273036001461 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 273036001462 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 273036001463 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 273036001464 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 273036001465 G-loop; other site 273036001466 DNA binding site [nucleotide binding] 273036001467 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 273036001468 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 273036001469 S17 interaction site [polypeptide binding]; other site 273036001470 S8 interaction site; other site 273036001471 16S rRNA interaction site [nucleotide binding]; other site 273036001472 streptomycin interaction site [chemical binding]; other site 273036001473 23S rRNA interaction site [nucleotide binding]; other site 273036001474 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 273036001475 30S ribosomal protein S7; Validated; Region: PRK05302 273036001476 elongation factor G; Reviewed; Region: PRK00007 273036001477 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 273036001478 G1 box; other site 273036001479 putative GEF interaction site [polypeptide binding]; other site 273036001480 GTP/Mg2+ binding site [chemical binding]; other site 273036001481 Switch I region; other site 273036001482 G2 box; other site 273036001483 G3 box; other site 273036001484 Switch II region; other site 273036001485 G4 box; other site 273036001486 G5 box; other site 273036001487 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 273036001488 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 273036001489 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 273036001490 elongation factor Tu; Reviewed; Region: PRK00049 273036001491 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 273036001492 G1 box; other site 273036001493 GEF interaction site [polypeptide binding]; other site 273036001494 GTP/Mg2+ binding site [chemical binding]; other site 273036001495 Switch I region; other site 273036001496 G2 box; other site 273036001497 G3 box; other site 273036001498 Switch II region; other site 273036001499 G4 box; other site 273036001500 G5 box; other site 273036001501 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 273036001502 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 273036001503 Antibiotic Binding Site [chemical binding]; other site 273036001504 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 273036001505 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 273036001506 metal binding site [ion binding]; metal-binding site 273036001507 dimer interface [polypeptide binding]; other site 273036001508 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 273036001509 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 273036001510 substrate-cofactor binding pocket; other site 273036001511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036001512 catalytic residue [active] 273036001513 chaperone protein HchA; Provisional; Region: PRK04155 273036001514 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 273036001515 conserved cys residue [active] 273036001516 ribulokinase; Provisional; Region: PRK04123 273036001517 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 273036001518 N- and C-terminal domain interface [polypeptide binding]; other site 273036001519 active site 273036001520 MgATP binding site [chemical binding]; other site 273036001521 catalytic site [active] 273036001522 metal binding site [ion binding]; metal-binding site 273036001523 carbohydrate binding site [chemical binding]; other site 273036001524 homodimer interface [polypeptide binding]; other site 273036001525 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 273036001526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273036001527 NAD(P) binding site [chemical binding]; other site 273036001528 active site 273036001529 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 273036001530 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 273036001531 homodimer interface [polypeptide binding]; other site 273036001532 substrate-cofactor binding pocket; other site 273036001533 catalytic residue [active] 273036001534 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 273036001535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036001536 motif II; other site 273036001537 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 273036001538 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 273036001539 Substrate-binding site [chemical binding]; other site 273036001540 Substrate specificity [chemical binding]; other site 273036001541 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 273036001542 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 273036001543 Substrate-binding site [chemical binding]; other site 273036001544 Substrate specificity [chemical binding]; other site 273036001545 probable cytosine deamidase 273036001546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036001547 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 273036001548 active site 273036001549 motif I; other site 273036001550 motif II; other site 273036001551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036001552 Predicted flavoprotein [General function prediction only]; Region: COG0431 273036001553 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 273036001554 Ser-Asp rich fibrinogen-binding/bone sialoprotein-binding protein 273036001555 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 273036001556 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 273036001557 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 273036001558 Cna protein B-type domain; Region: Cna_B; pfam05738 273036001559 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 273036001560 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 273036001561 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 273036001562 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 273036001563 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 273036001564 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 273036001565 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 273036001566 putative GTP cyclohydrolase; Provisional; Region: PRK13674 273036001567 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 273036001568 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 273036001569 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 273036001570 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 273036001571 active site 273036001572 trimer interface [polypeptide binding]; other site 273036001573 allosteric site; other site 273036001574 active site lid [active] 273036001575 hexamer (dimer of trimers) interface [polypeptide binding]; other site 273036001576 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 273036001577 active site 273036001578 dimer interface [polypeptide binding]; other site 273036001579 magnesium binding site [ion binding]; other site 273036001580 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 273036001581 tetramer interface [polypeptide binding]; other site 273036001582 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 273036001583 active site 273036001584 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 273036001585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036001586 motif II; other site 273036001587 proline/glycine betaine transporter; Provisional; Region: PRK10642 273036001588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036001589 putative substrate translocation pore; other site 273036001590 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 273036001591 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 273036001592 acyl-activating enzyme (AAE) consensus motif; other site 273036001593 AMP binding site [chemical binding]; other site 273036001594 active site 273036001595 CoA binding site [chemical binding]; other site 273036001596 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 273036001597 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 273036001598 dimer interface [polypeptide binding]; other site 273036001599 active site 273036001600 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 273036001601 dimer interface [polypeptide binding]; other site 273036001602 substrate binding site [chemical binding]; other site 273036001603 ATP binding site [chemical binding]; other site 273036001604 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 273036001605 ligand binding site [chemical binding]; other site 273036001606 active site 273036001607 UGI interface [polypeptide binding]; other site 273036001608 catalytic site [active] 273036001609 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 273036001610 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 273036001611 Uncharacterized conserved protein [Function unknown]; Region: COG3610 273036001612 Uncharacterized conserved protein [Function unknown]; Region: COG2966 273036001613 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 273036001614 putative heme peroxidase; Provisional; Region: PRK12276 273036001615 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 273036001616 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 273036001617 mevalonate kinase; Region: mevalon_kin; TIGR00549 273036001618 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 273036001619 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 273036001620 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 273036001621 diphosphomevalonate decarboxylase; Region: PLN02407 273036001622 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 273036001623 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 273036001624 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 273036001625 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 273036001626 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 273036001627 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 273036001628 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273036001629 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 273036001630 Predicted transcriptional regulator [Transcription]; Region: COG1959 273036001631 Transcriptional regulator; Region: Rrf2; pfam02082 273036001632 LXG domain of WXG superfamily; Region: LXG; pfam04740 273036001633 Protein of unknown function (DUF443); Region: DUF443; pfam04276 273036001634 Protein of unknown function (DUF443); Region: DUF443; pfam04276 273036001635 Protein of unknown function (DUF443); Region: DUF443; pfam04276 273036001636 Protein of unknown function (DUF443); Region: DUF443; pfam04276 273036001637 Protein of unknown function (DUF443); Region: DUF443; pfam04276 273036001638 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273036001639 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 273036001640 active site 273036001641 catalytic tetrad [active] 273036001642 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 273036001643 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 273036001644 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 273036001645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036001646 Coenzyme A binding pocket [chemical binding]; other site 273036001647 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 273036001648 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273036001649 Zn2+ binding site [ion binding]; other site 273036001650 Mg2+ binding site [ion binding]; other site 273036001651 YwhD family; Region: YwhD; pfam08741 273036001652 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 273036001653 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 273036001654 NAD binding site [chemical binding]; other site 273036001655 substrate binding site [chemical binding]; other site 273036001656 catalytic Zn binding site [ion binding]; other site 273036001657 tetramer interface [polypeptide binding]; other site 273036001658 structural Zn binding site [ion binding]; other site 273036001659 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 273036001660 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 273036001661 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 273036001662 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 273036001663 active site 273036001664 HIGH motif; other site 273036001665 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 273036001666 KMSK motif region; other site 273036001667 tRNA binding surface [nucleotide binding]; other site 273036001668 DALR anticodon binding domain; Region: DALR_1; smart00836 273036001669 anticodon binding site; other site 273036001670 transposase 273036001671 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 273036001672 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 273036001673 minor groove reading motif; other site 273036001674 helix-hairpin-helix signature motif; other site 273036001675 substrate binding pocket [chemical binding]; other site 273036001676 active site 273036001677 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 273036001678 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 273036001679 putative binding site residues; other site 273036001680 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 273036001681 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 273036001682 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273036001683 ABC-ATPase subunit interface; other site 273036001684 dimer interface [polypeptide binding]; other site 273036001685 putative PBP binding regions; other site 273036001686 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 273036001687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036001688 motif II; other site 273036001689 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 273036001690 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 273036001691 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 273036001692 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 273036001693 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 273036001694 Transcriptional regulators [Transcription]; Region: MarR; COG1846 273036001695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 273036001696 Protein of unknown function, DUF606; Region: DUF606; pfam04657 273036001697 hypothetical protein 273036001698 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 273036001699 active site 273036001700 DNA binding site [nucleotide binding] 273036001701 Int/Topo IB signature motif; other site 273036001702 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 273036001703 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 273036001704 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 273036001705 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 273036001706 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 273036001707 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 273036001708 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 273036001709 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 273036001710 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 273036001711 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 273036001712 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 273036001713 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 273036001714 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 273036001715 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 273036001716 metal binding site [ion binding]; metal-binding site 273036001717 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 273036001718 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273036001719 ABC-ATPase subunit interface; other site 273036001720 dimer interface [polypeptide binding]; other site 273036001721 putative PBP binding regions; other site 273036001722 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 273036001723 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 273036001724 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 273036001725 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 273036001726 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 273036001727 FeoA domain; Region: FeoA; pfam04023 273036001728 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 273036001729 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 273036001730 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 273036001731 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 273036001732 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 273036001733 Walker A/P-loop; other site 273036001734 ATP binding site [chemical binding]; other site 273036001735 Q-loop/lid; other site 273036001736 ABC transporter signature motif; other site 273036001737 Walker B; other site 273036001738 D-loop; other site 273036001739 H-loop/switch region; other site 273036001740 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 273036001741 ABC-2 type transporter; Region: ABC2_membrane; cl17235 273036001742 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 273036001743 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 273036001744 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 273036001745 active site 273036001746 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 273036001747 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 273036001748 active site 273036001749 nucleotide binding site [chemical binding]; other site 273036001750 HIGH motif; other site 273036001751 KMSKS motif; other site 273036001752 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 273036001753 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 273036001754 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 273036001755 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273036001756 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273036001757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273036001758 Walker A/P-loop; other site 273036001759 ATP binding site [chemical binding]; other site 273036001760 Q-loop/lid; other site 273036001761 ABC transporter signature motif; other site 273036001762 Walker B; other site 273036001763 D-loop; other site 273036001764 H-loop/switch region; other site 273036001765 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 273036001766 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 273036001767 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 273036001768 Uncharacterized conserved protein [Function unknown]; Region: COG1284 273036001769 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 273036001770 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 273036001771 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 273036001772 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 273036001773 Walker A/P-loop; other site 273036001774 ATP binding site [chemical binding]; other site 273036001775 Q-loop/lid; other site 273036001776 ABC transporter signature motif; other site 273036001777 Walker B; other site 273036001778 D-loop; other site 273036001779 H-loop/switch region; other site 273036001780 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 273036001781 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273036001782 ABC-ATPase subunit interface; other site 273036001783 dimer interface [polypeptide binding]; other site 273036001784 putative PBP binding regions; other site 273036001785 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 273036001786 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273036001787 ABC-ATPase subunit interface; other site 273036001788 dimer interface [polypeptide binding]; other site 273036001789 putative PBP binding regions; other site 273036001790 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 273036001791 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 273036001792 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 273036001793 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 273036001794 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 273036001795 Uncharacterized membrane protein [Function unknown]; Region: COG3949 273036001796 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 273036001797 Na binding site [ion binding]; other site 273036001798 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 273036001799 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 273036001800 substrate binding pocket [chemical binding]; other site 273036001801 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 273036001802 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 273036001803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036001804 Coenzyme A binding pocket [chemical binding]; other site 273036001805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 273036001806 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 273036001807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273036001808 NAD(P) binding site [chemical binding]; other site 273036001809 active site 273036001810 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273036001811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273036001812 active site 273036001813 phosphorylation site [posttranslational modification] 273036001814 intermolecular recognition site; other site 273036001815 dimerization interface [polypeptide binding]; other site 273036001816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273036001817 DNA binding site [nucleotide binding] 273036001818 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 273036001819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 273036001820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036001821 ATP binding site [chemical binding]; other site 273036001822 Mg2+ binding site [ion binding]; other site 273036001823 G-X-G motif; other site 273036001824 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 273036001825 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 273036001826 Walker A/P-loop; other site 273036001827 ATP binding site [chemical binding]; other site 273036001828 Q-loop/lid; other site 273036001829 ABC transporter signature motif; other site 273036001830 Walker B; other site 273036001831 D-loop; other site 273036001832 H-loop/switch region; other site 273036001833 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 273036001834 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 273036001835 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 273036001836 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 273036001837 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 273036001838 Surface antigen [General function prediction only]; Region: COG3942 273036001839 CHAP domain; Region: CHAP; pfam05257 273036001840 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 273036001841 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 273036001842 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 273036001843 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 273036001844 hypothetical protein; Provisional; Region: PRK12378 273036001845 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 273036001846 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 273036001847 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273036001848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273036001849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 273036001850 dimerization interface [polypeptide binding]; other site 273036001851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036001852 sugar efflux transporter; Region: 2A0120; TIGR00899 273036001853 putative substrate translocation pore; other site 273036001854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 273036001855 Serine incorporator (Serinc); Region: Serinc; pfam03348 273036001856 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 273036001857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036001858 Coenzyme A binding pocket [chemical binding]; other site 273036001859 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 273036001860 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 273036001861 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 273036001862 hypothetical protein; Validated; Region: PRK00124 273036001863 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 273036001864 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 273036001865 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 273036001866 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273036001867 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 273036001868 Walker A/P-loop; other site 273036001869 ATP binding site [chemical binding]; other site 273036001870 Q-loop/lid; other site 273036001871 ABC transporter signature motif; other site 273036001872 Walker B; other site 273036001873 D-loop; other site 273036001874 H-loop/switch region; other site 273036001875 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 273036001876 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273036001877 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 273036001878 Walker A/P-loop; other site 273036001879 ATP binding site [chemical binding]; other site 273036001880 Q-loop/lid; other site 273036001881 ABC transporter signature motif; other site 273036001882 Walker B; other site 273036001883 D-loop; other site 273036001884 H-loop/switch region; other site 273036001885 Transcriptional regulators [Transcription]; Region: MarR; COG1846 273036001886 MarR family; Region: MarR; pfam01047 273036001887 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 273036001888 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 273036001889 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 273036001890 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273036001891 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 273036001892 active site 273036001893 catalytic tetrad [active] 273036001894 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 273036001895 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 273036001896 transmembrane helices; other site 273036001897 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 273036001898 DNA photolyase; Region: DNA_photolyase; pfam00875 273036001899 Predicted membrane protein [Function unknown]; Region: COG4330 273036001900 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 273036001901 trimer interface [polypeptide binding]; other site 273036001902 putative Zn binding site [ion binding]; other site 273036001903 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 273036001904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036001905 putative substrate translocation pore; other site 273036001906 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 273036001907 putative deacylase active site [active] 273036001908 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 273036001909 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 273036001910 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 273036001911 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 273036001912 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 273036001913 putative substrate binding site [chemical binding]; other site 273036001914 putative ATP binding site [chemical binding]; other site 273036001915 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 273036001916 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273036001917 active site 273036001918 phosphorylation site [posttranslational modification] 273036001919 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 273036001920 active site 273036001921 P-loop; other site 273036001922 phosphorylation site [posttranslational modification] 273036001923 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 273036001924 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 273036001925 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 273036001926 active site 273036001927 dimer interface [polypeptide binding]; other site 273036001928 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 273036001929 Domain of unknown function DUF21; Region: DUF21; pfam01595 273036001930 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 273036001931 Transporter associated domain; Region: CorC_HlyC; pfam03471 273036001932 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273036001933 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 273036001934 active site 273036001935 catalytic tetrad [active] 273036001936 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 273036001937 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 273036001938 Ligand binding site; other site 273036001939 Putative Catalytic site; other site 273036001940 DXD motif; other site 273036001941 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 273036001942 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273036001943 dimer interface [polypeptide binding]; other site 273036001944 phosphorylation site [posttranslational modification] 273036001945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036001946 ATP binding site [chemical binding]; other site 273036001947 Mg2+ binding site [ion binding]; other site 273036001948 G-X-G motif; other site 273036001949 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273036001950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273036001951 active site 273036001952 phosphorylation site [posttranslational modification] 273036001953 intermolecular recognition site; other site 273036001954 dimerization interface [polypeptide binding]; other site 273036001955 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273036001956 DNA binding site [nucleotide binding] 273036001957 DoxX; Region: DoxX; pfam07681 273036001958 Electron transfer DM13; Region: DM13; pfam10517 273036001959 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 273036001960 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 273036001961 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 273036001962 active site 273036001963 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 273036001964 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 273036001965 Ligand Binding Site [chemical binding]; other site 273036001966 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 273036001967 Glutamine amidotransferase class-I; Region: GATase; pfam00117 273036001968 glutamine binding [chemical binding]; other site 273036001969 catalytic triad [active] 273036001970 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 273036001971 chorismate binding enzyme; Region: Chorismate_bind; cl10555 273036001972 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 273036001973 substrate-cofactor binding pocket; other site 273036001974 Aminotransferase class IV; Region: Aminotran_4; pfam01063 273036001975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036001976 catalytic residue [active] 273036001977 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 273036001978 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 273036001979 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 273036001980 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 273036001981 Sulfatase; Region: Sulfatase; pfam00884 273036001982 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 273036001983 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273036001984 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273036001985 ABC transporter; Region: ABC_tran_2; pfam12848 273036001986 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273036001987 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 273036001988 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273036001989 ATP binding site [chemical binding]; other site 273036001990 putative Mg++ binding site [ion binding]; other site 273036001991 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273036001992 nucleotide binding region [chemical binding]; other site 273036001993 ATP-binding site [chemical binding]; other site 273036001994 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 273036001995 HRDC domain; Region: HRDC; pfam00570 273036001996 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 273036001997 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 273036001998 Walker A/P-loop; other site 273036001999 ATP binding site [chemical binding]; other site 273036002000 Q-loop/lid; other site 273036002001 ABC transporter signature motif; other site 273036002002 Walker B; other site 273036002003 D-loop; other site 273036002004 H-loop/switch region; other site 273036002005 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 273036002006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036002007 dimer interface [polypeptide binding]; other site 273036002008 conserved gate region; other site 273036002009 ABC-ATPase subunit interface; other site 273036002010 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 273036002011 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 273036002012 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 273036002013 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273036002014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036002015 homodimer interface [polypeptide binding]; other site 273036002016 catalytic residue [active] 273036002017 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 273036002018 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 273036002019 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 273036002020 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 273036002021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036002022 putative substrate translocation pore; other site 273036002023 POT family; Region: PTR2; cl17359 273036002024 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 273036002025 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 273036002026 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 273036002027 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 273036002028 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 273036002029 Class I ribonucleotide reductase; Region: RNR_I; cd01679 273036002030 active site 273036002031 dimer interface [polypeptide binding]; other site 273036002032 catalytic residues [active] 273036002033 effector binding site; other site 273036002034 R2 peptide binding site; other site 273036002035 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 273036002036 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 273036002037 dimer interface [polypeptide binding]; other site 273036002038 putative radical transfer pathway; other site 273036002039 diiron center [ion binding]; other site 273036002040 tyrosyl radical; other site 273036002041 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273036002042 ABC-ATPase subunit interface; other site 273036002043 dimer interface [polypeptide binding]; other site 273036002044 putative PBP binding regions; other site 273036002045 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273036002046 ABC-ATPase subunit interface; other site 273036002047 dimer interface [polypeptide binding]; other site 273036002048 putative PBP binding regions; other site 273036002049 ferrichrome ATP-binding ABC transporter 273036002050 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 273036002051 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 273036002052 putative ligand binding residues [chemical binding]; other site 273036002053 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 273036002054 CHY zinc finger; Region: zf-CHY; pfam05495 273036002055 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 273036002056 FAD binding domain; Region: FAD_binding_4; pfam01565 273036002057 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 273036002058 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 273036002059 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 273036002060 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 273036002061 peptidase T; Region: peptidase-T; TIGR01882 273036002062 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 273036002063 metal binding site [ion binding]; metal-binding site 273036002064 dimer interface [polypeptide binding]; other site 273036002065 Uncharacterized conserved protein [Function unknown]; Region: COG3610 273036002066 Uncharacterized conserved protein [Function unknown]; Region: COG2966 273036002067 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 273036002068 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 273036002069 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 273036002070 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 273036002071 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 273036002072 metal binding site [ion binding]; metal-binding site 273036002073 active site 273036002074 I-site; other site 273036002075 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 273036002076 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 273036002077 Mg++ binding site [ion binding]; other site 273036002078 putative catalytic motif [active] 273036002079 substrate binding site [chemical binding]; other site 273036002080 Uncharacterized conserved protein [Function unknown]; Region: COG1739 273036002081 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 273036002082 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 273036002083 EDD domain protein, DegV family; Region: DegV; TIGR00762 273036002084 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 273036002085 DEAD-like helicases superfamily; Region: DEXDc; smart00487 273036002086 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273036002087 ATP binding site [chemical binding]; other site 273036002088 putative Mg++ binding site [ion binding]; other site 273036002089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273036002090 nucleotide binding region [chemical binding]; other site 273036002091 ATP-binding site [chemical binding]; other site 273036002092 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 273036002093 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273036002094 active site 273036002095 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 273036002096 30S subunit binding site; other site 273036002097 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 273036002098 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 273036002099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 273036002100 nucleotide binding region [chemical binding]; other site 273036002101 ATP-binding site [chemical binding]; other site 273036002102 SEC-C motif; Region: SEC-C; pfam02810 273036002103 peptide chain release factor 2; Provisional; Region: PRK06746 273036002104 This domain is found in peptide chain release factors; Region: PCRF; smart00937 273036002105 RF-1 domain; Region: RF-1; pfam00472 273036002106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273036002107 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273036002108 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 273036002109 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 273036002110 Surface antigen [General function prediction only]; Region: COG3942 273036002111 CHAP domain; Region: CHAP; pfam05257 273036002112 HD domain; Region: HD_3; cl17350 273036002113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 273036002114 excinuclease ABC subunit B; Provisional; Region: PRK05298 273036002115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273036002116 ATP binding site [chemical binding]; other site 273036002117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273036002118 nucleotide binding region [chemical binding]; other site 273036002119 ATP-binding site [chemical binding]; other site 273036002120 Ultra-violet resistance protein B; Region: UvrB; pfam12344 273036002121 UvrB/uvrC motif; Region: UVR; pfam02151 273036002122 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 273036002123 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 273036002124 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 273036002125 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 273036002126 HPr kinase/phosphorylase; Provisional; Region: PRK05428 273036002127 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 273036002128 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 273036002129 Hpr binding site; other site 273036002130 active site 273036002131 homohexamer subunit interaction site [polypeptide binding]; other site 273036002132 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 273036002133 putative acyl transferase; Provisional; Region: PRK10191 273036002134 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 273036002135 trimer interface [polypeptide binding]; other site 273036002136 active site 273036002137 substrate binding site [chemical binding]; other site 273036002138 CoA binding site [chemical binding]; other site 273036002139 TPR repeat; Region: TPR_11; pfam13414 273036002140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 273036002141 binding surface 273036002142 TPR motif; other site 273036002143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273036002144 binding surface 273036002145 TPR motif; other site 273036002146 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 273036002147 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273036002148 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273036002149 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 273036002150 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 273036002151 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 273036002152 phosphate binding site [ion binding]; other site 273036002153 dimer interface [polypeptide binding]; other site 273036002154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 273036002155 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 273036002156 Clp protease; Region: CLP_protease; pfam00574 273036002157 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 273036002158 oligomer interface [polypeptide binding]; other site 273036002159 active site residues [active] 273036002160 malate dehydrogenase; Provisional; Region: PRK13529 273036002161 Malic enzyme, N-terminal domain; Region: malic; pfam00390 273036002162 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 273036002163 NAD(P) binding site [chemical binding]; other site 273036002164 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 273036002165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273036002166 NAD(P) binding site [chemical binding]; other site 273036002167 active site 273036002168 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 273036002169 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 273036002170 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 273036002171 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 273036002172 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 273036002173 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 273036002174 Phosphoglycerate kinase; Region: PGK; pfam00162 273036002175 substrate binding site [chemical binding]; other site 273036002176 hinge regions; other site 273036002177 ADP binding site [chemical binding]; other site 273036002178 catalytic site [active] 273036002179 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 273036002180 triosephosphate isomerase; Provisional; Region: PRK14565 273036002181 substrate binding site [chemical binding]; other site 273036002182 dimer interface [polypeptide binding]; other site 273036002183 catalytic triad [active] 273036002184 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 273036002185 phosphoglyceromutase; Provisional; Region: PRK05434 273036002186 enolase; Provisional; Region: eno; PRK00077 273036002187 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 273036002188 dimer interface [polypeptide binding]; other site 273036002189 metal binding site [ion binding]; metal-binding site 273036002190 substrate binding pocket [chemical binding]; other site 273036002191 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 273036002192 Esterase/lipase [General function prediction only]; Region: COG1647 273036002193 ribonuclease R; Region: RNase_R; TIGR02063 273036002194 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 273036002195 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 273036002196 RNB domain; Region: RNB; pfam00773 273036002197 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 273036002198 RNA binding site [nucleotide binding]; other site 273036002199 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 273036002200 SmpB-tmRNA interface; other site 273036002201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 273036002202 Transposase; Region: HTH_Tnp_1; cl17663 273036002203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036002204 Coenzyme A binding pocket [chemical binding]; other site 273036002205 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 273036002206 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 273036002207 Staphylococcal nuclease homologues; Region: SNc; smart00318 273036002208 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 273036002209 Catalytic site; other site 273036002210 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 273036002211 DNA-binding site [nucleotide binding]; DNA binding site 273036002212 RNA-binding motif; other site 273036002213 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 273036002214 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 273036002215 catalytic core [active] 273036002216 Lysine efflux permease [General function prediction only]; Region: COG1279 273036002217 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 273036002218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 273036002219 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 273036002220 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 273036002221 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 273036002222 active site 273036002223 catalytic residue [active] 273036002224 dimer interface [polypeptide binding]; other site 273036002225 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 273036002226 putative FMN binding site [chemical binding]; other site 273036002227 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 273036002228 catalytic residues [active] 273036002229 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 273036002230 ArsC family; Region: ArsC; pfam03960 273036002231 putative ArsC-like catalytic residues; other site 273036002232 putative TRX-like catalytic residues [active] 273036002233 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 273036002234 lipoyl attachment site [posttranslational modification]; other site 273036002235 conserved hypothetical protein 273036002236 hypothetical protein 273036002237 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 273036002238 catalytic residues [active] 273036002239 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 273036002240 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 273036002241 Walker A/P-loop; other site 273036002242 ATP binding site [chemical binding]; other site 273036002243 Q-loop/lid; other site 273036002244 ABC transporter signature motif; other site 273036002245 Walker B; other site 273036002246 D-loop; other site 273036002247 H-loop/switch region; other site 273036002248 NIL domain; Region: NIL; pfam09383 273036002249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036002250 dimer interface [polypeptide binding]; other site 273036002251 conserved gate region; other site 273036002252 ABC-ATPase subunit interface; other site 273036002253 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 273036002254 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 273036002255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 273036002256 Predicted membrane protein [Function unknown]; Region: COG2035 273036002257 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 273036002258 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 273036002259 Walker A/P-loop; other site 273036002260 ATP binding site [chemical binding]; other site 273036002261 Q-loop/lid; other site 273036002262 ABC transporter signature motif; other site 273036002263 Walker B; other site 273036002264 D-loop; other site 273036002265 H-loop/switch region; other site 273036002266 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 273036002267 FeS assembly protein SufD; Region: sufD; TIGR01981 273036002268 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 273036002269 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 273036002270 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273036002271 catalytic residue [active] 273036002272 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 273036002273 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 273036002274 trimerization site [polypeptide binding]; other site 273036002275 active site 273036002276 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 273036002277 FeS assembly protein SufB; Region: sufB; TIGR01980 273036002278 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 273036002279 active site 273036002280 DNA binding site [nucleotide binding] 273036002281 Int/Topo IB signature motif; other site 273036002282 Small integral membrane protein [Function unknown]; Region: COG5546 273036002283 CHAP domain; Region: CHAP; pfam05257 273036002284 beta-channel forming cytolysin; Region: hlyII; TIGR01002 273036002285 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 273036002286 Domain of unknown function DUF21; Region: DUF21; pfam01595 273036002287 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 273036002288 conserved hypothetical protein 273036002289 Uncharacterized conserved protein [Function unknown]; Region: COG1801 273036002290 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 273036002291 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 273036002292 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 273036002293 active site 273036002294 metal binding site [ion binding]; metal-binding site 273036002295 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 273036002296 lipoyl synthase; Provisional; Region: PRK05481 273036002297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273036002298 FeS/SAM binding site; other site 273036002299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 273036002300 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 273036002301 Uncharacterized conserved protein [Function unknown]; Region: COG2445 273036002302 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 273036002303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036002304 active site 273036002305 motif I; other site 273036002306 motif II; other site 273036002307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036002308 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 273036002309 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 273036002310 dimerization interface [polypeptide binding]; other site 273036002311 ligand binding site [chemical binding]; other site 273036002312 NADP binding site [chemical binding]; other site 273036002313 catalytic site [active] 273036002314 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 273036002315 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 273036002316 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 273036002317 acyl-activating enzyme (AAE) consensus motif; other site 273036002318 AMP binding site [chemical binding]; other site 273036002319 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 273036002320 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 273036002321 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 273036002322 DltD N-terminal region; Region: DltD_N; pfam04915 273036002323 DltD central region; Region: DltD_M; pfam04918 273036002324 DltD C-terminal region; Region: DltD_C; pfam04914 273036002325 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 273036002326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 273036002327 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 273036002328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273036002329 hypothetical protein; Provisional; Region: PRK13669 273036002330 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 273036002331 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 273036002332 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273036002333 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 273036002334 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 273036002335 interface (dimer of trimers) [polypeptide binding]; other site 273036002336 Substrate-binding/catalytic site; other site 273036002337 Zn-binding sites [ion binding]; other site 273036002338 Predicted permease [General function prediction only]; Region: COG2056 273036002339 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 273036002340 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 273036002341 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 273036002342 CoenzymeA binding site [chemical binding]; other site 273036002343 subunit interaction site [polypeptide binding]; other site 273036002344 PHB binding site; other site 273036002345 transposase 273036002346 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273036002347 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 273036002348 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 273036002349 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 273036002350 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 273036002351 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 273036002352 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 273036002353 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 273036002354 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 273036002355 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 273036002356 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 273036002357 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 273036002358 Kinase associated protein B; Region: KapB; pfam08810 273036002359 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 273036002360 active site 273036002361 general stress protein 13; Validated; Region: PRK08059 273036002362 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 273036002363 RNA binding site [nucleotide binding]; other site 273036002364 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 273036002365 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 273036002366 putative active site [active] 273036002367 putative FMN binding site [chemical binding]; other site 273036002368 putative substrate binding site [chemical binding]; other site 273036002369 putative catalytic residue [active] 273036002370 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 273036002371 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 273036002372 inhibitor-cofactor binding pocket; inhibition site 273036002373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036002374 catalytic residue [active] 273036002375 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 273036002376 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 273036002377 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 273036002378 NAD(P) binding site [chemical binding]; other site 273036002379 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 273036002380 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 273036002381 active site 273036002382 catalytic site [active] 273036002383 metal binding site [ion binding]; metal-binding site 273036002384 argininosuccinate lyase; Provisional; Region: PRK00855 273036002385 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 273036002386 active sites [active] 273036002387 tetramer interface [polypeptide binding]; other site 273036002388 argininosuccinate synthase; Provisional; Region: PRK13820 273036002389 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 273036002390 ANP binding site [chemical binding]; other site 273036002391 Substrate Binding Site II [chemical binding]; other site 273036002392 Substrate Binding Site I [chemical binding]; other site 273036002393 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 273036002394 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 273036002395 active site 273036002396 dimer interface [polypeptide binding]; other site 273036002397 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 273036002398 dimer interface [polypeptide binding]; other site 273036002399 active site 273036002400 Uncharacterized conserved protein [Function unknown]; Region: COG0398 273036002401 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 273036002402 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 273036002403 Catalytic site [active] 273036002404 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 273036002405 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 273036002406 Catalytic site [active] 273036002407 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 273036002408 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 273036002409 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 273036002410 Part of AAA domain; Region: AAA_19; pfam13245 273036002411 Family description; Region: UvrD_C_2; pfam13538 273036002412 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 273036002413 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 273036002414 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 273036002415 hypothetical protein; Provisional; Region: PRK13673 273036002416 coenzyme A disulfide reductase; Provisional; Region: PRK13512 273036002417 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273036002418 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273036002419 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 273036002420 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 273036002421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036002422 active site 273036002423 motif I; other site 273036002424 motif II; other site 273036002425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036002426 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 273036002427 probable membrane-embedded acyltransferase 273036002428 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 273036002429 Clp amino terminal domain; Region: Clp_N; pfam02861 273036002430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036002431 Walker A motif; other site 273036002432 ATP binding site [chemical binding]; other site 273036002433 Walker B motif; other site 273036002434 arginine finger; other site 273036002435 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 273036002436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036002437 Walker A motif; other site 273036002438 ATP binding site [chemical binding]; other site 273036002439 Walker B motif; other site 273036002440 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 273036002441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273036002442 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273036002443 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 273036002444 dimerization interface [polypeptide binding]; other site 273036002445 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 273036002446 substrate binding site [chemical binding]; other site 273036002447 MAP domain; Region: MAP; pfam03642 273036002448 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 273036002449 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 273036002450 dimer interface [polypeptide binding]; other site 273036002451 active site 273036002452 CoA binding pocket [chemical binding]; other site 273036002453 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 273036002454 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 273036002455 dimer interface [polypeptide binding]; other site 273036002456 active site 273036002457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 273036002458 Transposase; Region: DDE_Tnp_ISL3; pfam01610 273036002459 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 273036002460 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 273036002461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036002462 dimer interface [polypeptide binding]; other site 273036002463 conserved gate region; other site 273036002464 putative PBP binding loops; other site 273036002465 ABC-ATPase subunit interface; other site 273036002466 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 273036002467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036002468 dimer interface [polypeptide binding]; other site 273036002469 conserved gate region; other site 273036002470 putative PBP binding loops; other site 273036002471 ABC-ATPase subunit interface; other site 273036002472 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 273036002473 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273036002474 Walker A/P-loop; other site 273036002475 ATP binding site [chemical binding]; other site 273036002476 Q-loop/lid; other site 273036002477 ABC transporter signature motif; other site 273036002478 Walker B; other site 273036002479 D-loop; other site 273036002480 H-loop/switch region; other site 273036002481 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273036002482 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 273036002483 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273036002484 Walker A/P-loop; other site 273036002485 ATP binding site [chemical binding]; other site 273036002486 Q-loop/lid; other site 273036002487 ABC transporter signature motif; other site 273036002488 Walker B; other site 273036002489 D-loop; other site 273036002490 H-loop/switch region; other site 273036002491 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273036002492 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 273036002493 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 273036002494 peptide binding site [polypeptide binding]; other site 273036002495 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 273036002496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036002497 ABC-ATPase subunit interface; other site 273036002498 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 273036002499 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 273036002500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036002501 dimer interface [polypeptide binding]; other site 273036002502 conserved gate region; other site 273036002503 putative PBP binding loops; other site 273036002504 ABC-ATPase subunit interface; other site 273036002505 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 273036002506 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273036002507 Walker A/P-loop; other site 273036002508 ATP binding site [chemical binding]; other site 273036002509 Q-loop/lid; other site 273036002510 ABC transporter signature motif; other site 273036002511 Walker B; other site 273036002512 D-loop; other site 273036002513 H-loop/switch region; other site 273036002514 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273036002515 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 273036002516 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273036002517 Walker A/P-loop; other site 273036002518 ATP binding site [chemical binding]; other site 273036002519 Q-loop/lid; other site 273036002520 ABC transporter signature motif; other site 273036002521 Walker B; other site 273036002522 D-loop; other site 273036002523 H-loop/switch region; other site 273036002524 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273036002525 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 273036002526 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 273036002527 oligopeptide binding protein 273036002528 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 273036002529 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 273036002530 active site 273036002531 HIGH motif; other site 273036002532 dimer interface [polypeptide binding]; other site 273036002533 KMSKS motif; other site 273036002534 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 273036002535 ArsC family; Region: ArsC; pfam03960 273036002536 putative catalytic residues [active] 273036002537 thiol/disulfide switch; other site 273036002538 adaptor protein; Provisional; Region: PRK02315 273036002539 Competence protein CoiA-like family; Region: CoiA; cl11541 273036002540 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 273036002541 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 273036002542 active site 273036002543 Zn binding site [ion binding]; other site 273036002544 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 273036002545 Thioredoxin; Region: Thioredoxin_5; pfam13743 273036002546 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 273036002547 apolar tunnel; other site 273036002548 heme binding site [chemical binding]; other site 273036002549 dimerization interface [polypeptide binding]; other site 273036002550 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 273036002551 putative active site [active] 273036002552 putative metal binding residues [ion binding]; other site 273036002553 signature motif; other site 273036002554 putative triphosphate binding site [ion binding]; other site 273036002555 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 273036002556 synthetase active site [active] 273036002557 NTP binding site [chemical binding]; other site 273036002558 metal binding site [ion binding]; metal-binding site 273036002559 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 273036002560 ATP-NAD kinase; Region: NAD_kinase; pfam01513 273036002561 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 273036002562 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 273036002563 active site 273036002564 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 273036002565 MgtE intracellular N domain; Region: MgtE_N; smart00924 273036002566 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 273036002567 Divalent cation transporter; Region: MgtE; pfam01769 273036002568 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 273036002569 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 273036002570 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 273036002571 TrkA-N domain; Region: TrkA_N; pfam02254 273036002572 TrkA-C domain; Region: TrkA_C; pfam02080 273036002573 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 273036002574 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 273036002575 NAD binding site [chemical binding]; other site 273036002576 homotetramer interface [polypeptide binding]; other site 273036002577 homodimer interface [polypeptide binding]; other site 273036002578 substrate binding site [chemical binding]; other site 273036002579 active site 273036002580 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 273036002581 Domain of unknown function DUF20; Region: UPF0118; pfam01594 273036002582 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 273036002583 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 273036002584 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 273036002585 Putative esterase; Region: Esterase; pfam00756 273036002586 hypothetical protein; Provisional; Region: PRK13679 273036002587 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 273036002588 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273036002589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036002590 putative substrate translocation pore; other site 273036002591 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 273036002592 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 273036002593 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 273036002594 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 273036002595 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 273036002596 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 273036002597 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273036002598 YueH-like protein; Region: YueH; pfam14166 273036002599 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 273036002600 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 273036002601 G1 box; other site 273036002602 putative GEF interaction site [polypeptide binding]; other site 273036002603 GTP/Mg2+ binding site [chemical binding]; other site 273036002604 Switch I region; other site 273036002605 G2 box; other site 273036002606 G3 box; other site 273036002607 Switch II region; other site 273036002608 G4 box; other site 273036002609 G5 box; other site 273036002610 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 273036002611 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 273036002612 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 273036002613 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 273036002614 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 273036002615 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 273036002616 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 273036002617 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 273036002618 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 273036002619 active site 273036002620 metal binding site [ion binding]; metal-binding site 273036002621 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 273036002622 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 273036002623 IDEAL domain; Region: IDEAL; pfam08858 273036002624 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 273036002625 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 273036002626 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 273036002627 CAAX protease self-immunity; Region: Abi; pfam02517 273036002628 exported protein 273036002629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 273036002630 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 273036002631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 273036002632 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 273036002633 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 273036002634 Walker A/P-loop; other site 273036002635 ATP binding site [chemical binding]; other site 273036002636 Q-loop/lid; other site 273036002637 ABC transporter signature motif; other site 273036002638 Walker B; other site 273036002639 D-loop; other site 273036002640 H-loop/switch region; other site 273036002641 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 273036002642 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 273036002643 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 273036002644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 273036002645 Integrase core domain; Region: rve; pfam00665 273036002646 Predicted membrane protein [Function unknown]; Region: COG2259 273036002647 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 273036002648 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 273036002649 intersubunit interface [polypeptide binding]; other site 273036002650 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 273036002651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036002652 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 273036002653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 273036002654 Coenzyme A binding pocket [chemical binding]; other site 273036002655 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 273036002656 UbiA prenyltransferase family; Region: UbiA; pfam01040 273036002657 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 273036002658 isochorismate synthases; Region: isochor_syn; TIGR00543 273036002659 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 273036002660 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 273036002661 dimer interface [polypeptide binding]; other site 273036002662 tetramer interface [polypeptide binding]; other site 273036002663 PYR/PP interface [polypeptide binding]; other site 273036002664 TPP binding site [chemical binding]; other site 273036002665 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 273036002666 TPP-binding site; other site 273036002667 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 273036002668 PGAP1-like protein; Region: PGAP1; pfam07819 273036002669 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 273036002670 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 273036002671 substrate binding site [chemical binding]; other site 273036002672 oxyanion hole (OAH) forming residues; other site 273036002673 trimer interface [polypeptide binding]; other site 273036002674 Staphostatin B; Region: Staphostatin_B; pfam09023 273036002675 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 273036002676 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 273036002677 aminotransferase A; Validated; Region: PRK07683 273036002678 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273036002679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036002680 homodimer interface [polypeptide binding]; other site 273036002681 catalytic residue [active] 273036002682 conserved hypothetical protein 273036002683 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 273036002684 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 273036002685 amidase catalytic site [active] 273036002686 Zn binding residues [ion binding]; other site 273036002687 substrate binding site [chemical binding]; other site 273036002688 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 273036002689 Lysozyme subfamily 2; Region: LYZ2; smart00047 273036002690 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036002691 Coenzyme A binding pocket [chemical binding]; other site 273036002692 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 273036002693 Transcriptional regulator [Transcription]; Region: LytR; COG1316 273036002694 Beta-lactamase; Region: Beta-lactamase; pfam00144 273036002695 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 273036002696 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 273036002697 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 273036002698 Subunit I/III interface [polypeptide binding]; other site 273036002699 Subunit III/IV interface [polypeptide binding]; other site 273036002700 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 273036002701 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 273036002702 D-pathway; other site 273036002703 Putative ubiquinol binding site [chemical binding]; other site 273036002704 Low-spin heme (heme b) binding site [chemical binding]; other site 273036002705 Putative water exit pathway; other site 273036002706 Binuclear center (heme o3/CuB) [ion binding]; other site 273036002707 K-pathway; other site 273036002708 Putative proton exit pathway; other site 273036002709 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 273036002710 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 273036002711 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 273036002712 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 273036002713 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 273036002714 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 273036002715 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 273036002716 homodimer interface [polypeptide binding]; other site 273036002717 NADP binding site [chemical binding]; other site 273036002718 substrate binding site [chemical binding]; other site 273036002719 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 273036002720 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 273036002721 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 273036002722 NAD binding site [chemical binding]; other site 273036002723 ATP-grasp domain; Region: ATP-grasp; pfam02222 273036002724 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 273036002725 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 273036002726 ATP binding site [chemical binding]; other site 273036002727 active site 273036002728 substrate binding site [chemical binding]; other site 273036002729 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 273036002730 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 273036002731 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 273036002732 putative active site [active] 273036002733 catalytic triad [active] 273036002734 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 273036002735 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 273036002736 dimerization interface [polypeptide binding]; other site 273036002737 ATP binding site [chemical binding]; other site 273036002738 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 273036002739 dimerization interface [polypeptide binding]; other site 273036002740 ATP binding site [chemical binding]; other site 273036002741 amidophosphoribosyltransferase; Provisional; Region: PRK07272 273036002742 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 273036002743 active site 273036002744 tetramer interface [polypeptide binding]; other site 273036002745 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273036002746 active site 273036002747 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 273036002748 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 273036002749 dimerization interface [polypeptide binding]; other site 273036002750 putative ATP binding site [chemical binding]; other site 273036002751 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 273036002752 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 273036002753 active site 273036002754 substrate binding site [chemical binding]; other site 273036002755 cosubstrate binding site; other site 273036002756 catalytic site [active] 273036002757 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 273036002758 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 273036002759 purine monophosphate binding site [chemical binding]; other site 273036002760 dimer interface [polypeptide binding]; other site 273036002761 putative catalytic residues [active] 273036002762 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 273036002763 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 273036002764 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 273036002765 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 273036002766 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 273036002767 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 273036002768 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 273036002769 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 273036002770 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 273036002771 Walker A/P-loop; other site 273036002772 ATP binding site [chemical binding]; other site 273036002773 Q-loop/lid; other site 273036002774 ABC transporter signature motif; other site 273036002775 Walker B; other site 273036002776 D-loop; other site 273036002777 H-loop/switch region; other site 273036002778 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 273036002779 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 273036002780 Walker A/P-loop; other site 273036002781 ATP binding site [chemical binding]; other site 273036002782 Q-loop/lid; other site 273036002783 ABC transporter signature motif; other site 273036002784 Walker B; other site 273036002785 D-loop; other site 273036002786 H-loop/switch region; other site 273036002787 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 273036002788 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 273036002789 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 273036002790 putative RNA binding site [nucleotide binding]; other site 273036002791 Methyltransferase domain; Region: Methyltransf_26; pfam13659 273036002792 Domain of unknown function (DUF697); Region: DUF697; cl12064 273036002793 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 273036002794 dimerization domain swap beta strand [polypeptide binding]; other site 273036002795 regulatory protein interface [polypeptide binding]; other site 273036002796 active site 273036002797 regulatory phosphorylation site [posttranslational modification]; other site 273036002798 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 273036002799 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 273036002800 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 273036002801 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 273036002802 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 273036002803 catalytic residues [active] 273036002804 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 273036002805 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 273036002806 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 273036002807 TrkA-N domain; Region: TrkA_N; pfam02254 273036002808 TrkA-C domain; Region: TrkA_C; pfam02080 273036002809 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 273036002810 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 273036002811 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 273036002812 hypothetical protein; Provisional; Region: PRK13667 273036002813 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 273036002814 active site 273036002815 catalytic residues [active] 273036002816 metal binding site [ion binding]; metal-binding site 273036002817 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 273036002818 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 273036002819 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 273036002820 TPP-binding site [chemical binding]; other site 273036002821 tetramer interface [polypeptide binding]; other site 273036002822 heterodimer interface [polypeptide binding]; other site 273036002823 phosphorylation loop region [posttranslational modification] 273036002824 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 273036002825 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 273036002826 alpha subunit interface [polypeptide binding]; other site 273036002827 TPP binding site [chemical binding]; other site 273036002828 heterodimer interface [polypeptide binding]; other site 273036002829 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 273036002830 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 273036002831 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 273036002832 E3 interaction surface; other site 273036002833 lipoyl attachment site [posttranslational modification]; other site 273036002834 e3 binding domain; Region: E3_binding; pfam02817 273036002835 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 273036002836 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 273036002837 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 273036002838 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273036002839 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 273036002840 hypothetical protein; Provisional; Region: PRK04387 273036002841 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 273036002842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273036002843 non-specific DNA binding site [nucleotide binding]; other site 273036002844 salt bridge; other site 273036002845 sequence-specific DNA binding site [nucleotide binding]; other site 273036002846 Cupin domain; Region: Cupin_2; pfam07883 273036002847 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 273036002848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273036002849 Walker A/P-loop; other site 273036002850 ATP binding site [chemical binding]; other site 273036002851 Q-loop/lid; other site 273036002852 ABC transporter signature motif; other site 273036002853 Walker B; other site 273036002854 D-loop; other site 273036002855 H-loop/switch region; other site 273036002856 TOBE domain; Region: TOBE_2; pfam08402 273036002857 spermidine/putrescine ABC transporter permease protein 273036002858 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 273036002859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036002860 dimer interface [polypeptide binding]; other site 273036002861 conserved gate region; other site 273036002862 putative PBP binding loops; other site 273036002863 ABC-ATPase subunit interface; other site 273036002864 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 273036002865 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 273036002866 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 273036002867 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 273036002868 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 273036002869 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 273036002870 manganese transport protein MntH; Reviewed; Region: PRK00701 273036002871 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 273036002872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 273036002873 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 273036002874 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 273036002875 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 273036002876 active site 273036002877 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 273036002878 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 273036002879 G1 box; other site 273036002880 putative GEF interaction site [polypeptide binding]; other site 273036002881 GTP/Mg2+ binding site [chemical binding]; other site 273036002882 Switch I region; other site 273036002883 G2 box; other site 273036002884 G3 box; other site 273036002885 Switch II region; other site 273036002886 G4 box; other site 273036002887 G5 box; other site 273036002888 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 273036002889 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 273036002890 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 273036002891 hypothetical protein; Provisional; Region: PRK13666 273036002892 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 273036002893 pyruvate carboxylase; Reviewed; Region: PRK12999 273036002894 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 273036002895 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 273036002896 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 273036002897 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 273036002898 active site 273036002899 catalytic residues [active] 273036002900 metal binding site [ion binding]; metal-binding site 273036002901 homodimer binding site [polypeptide binding]; other site 273036002902 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 273036002903 carboxyltransferase (CT) interaction site; other site 273036002904 biotinylation site [posttranslational modification]; other site 273036002905 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 273036002906 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 273036002907 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 273036002908 UbiA prenyltransferase family; Region: UbiA; pfam01040 273036002909 Predicted membrane protein [Function unknown]; Region: COG2322 273036002910 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 273036002911 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 273036002912 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 273036002913 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 273036002914 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 273036002915 putative active site [active] 273036002916 catalytic site [active] 273036002917 putative metal binding site [ion binding]; other site 273036002918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 273036002919 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 273036002920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036002921 S-adenosylmethionine binding site [chemical binding]; other site 273036002922 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 273036002923 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 273036002924 active site 273036002925 (T/H)XGH motif; other site 273036002926 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 273036002927 hypothetical protein; Provisional; Region: PRK13670 273036002928 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 273036002929 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 273036002930 heme uptake protein IsdB; Region: IsdB; TIGR03657 273036002931 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 273036002932 NEAr Transporter domain; Region: NEAT; smart00725 273036002933 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 273036002934 heme-binding site [chemical binding]; other site 273036002935 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 273036002936 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 273036002937 heme-binding site [chemical binding]; other site 273036002938 heme uptake protein IsdC; Region: IsdC; TIGR03656 273036002939 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 273036002940 heme-binding site [chemical binding]; other site 273036002941 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 273036002942 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 273036002943 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 273036002944 intersubunit interface [polypeptide binding]; other site 273036002945 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 273036002946 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273036002947 ABC-ATPase subunit interface; other site 273036002948 dimer interface [polypeptide binding]; other site 273036002949 putative PBP binding regions; other site 273036002950 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 273036002951 active site 273036002952 catalytic site [active] 273036002953 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 273036002954 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 273036002955 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 273036002956 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 273036002957 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 273036002958 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 273036002959 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 273036002960 dimer interface [polypeptide binding]; other site 273036002961 motif 1; other site 273036002962 active site 273036002963 motif 2; other site 273036002964 motif 3; other site 273036002965 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 273036002966 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 273036002967 putative tRNA-binding site [nucleotide binding]; other site 273036002968 B3/4 domain; Region: B3_4; pfam03483 273036002969 tRNA synthetase B5 domain; Region: B5; smart00874 273036002970 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 273036002971 dimer interface [polypeptide binding]; other site 273036002972 motif 1; other site 273036002973 motif 3; other site 273036002974 motif 2; other site 273036002975 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 273036002976 ribonuclease HIII; Provisional; Region: PRK00996 273036002977 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 273036002978 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 273036002979 RNA/DNA hybrid binding site [nucleotide binding]; other site 273036002980 active site 273036002981 Cell division protein ZapA; Region: ZapA; cl01146 273036002982 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 273036002983 Colicin V production protein; Region: Colicin_V; pfam02674 273036002984 hypothetical protein; Provisional; Region: PRK08609 273036002985 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 273036002986 active site 273036002987 primer binding site [nucleotide binding]; other site 273036002988 NTP binding site [chemical binding]; other site 273036002989 metal binding triad [ion binding]; metal-binding site 273036002990 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 273036002991 active site 273036002992 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 273036002993 MutS domain III; Region: MutS_III; pfam05192 273036002994 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 273036002995 Walker A/P-loop; other site 273036002996 ATP binding site [chemical binding]; other site 273036002997 Q-loop/lid; other site 273036002998 ABC transporter signature motif; other site 273036002999 Walker B; other site 273036003000 D-loop; other site 273036003001 H-loop/switch region; other site 273036003002 Smr domain; Region: Smr; pfam01713 273036003003 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 273036003004 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 273036003005 catalytic residues [active] 273036003006 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 273036003007 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 273036003008 GIY-YIG motif/motif A; other site 273036003009 active site 273036003010 catalytic site [active] 273036003011 putative DNA binding site [nucleotide binding]; other site 273036003012 metal binding site [ion binding]; metal-binding site 273036003013 UvrB/uvrC motif; Region: UVR; pfam02151 273036003014 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 273036003015 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 273036003016 putative Iron-sulfur protein interface [polypeptide binding]; other site 273036003017 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 273036003018 proximal heme binding site [chemical binding]; other site 273036003019 distal heme binding site [chemical binding]; other site 273036003020 putative dimer interface [polypeptide binding]; other site 273036003021 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 273036003022 L-aspartate oxidase; Provisional; Region: PRK06175 273036003023 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 273036003024 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 273036003025 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 273036003026 glutamate racemase; Provisional; Region: PRK00865 273036003027 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 273036003028 active site 273036003029 dimerization interface [polypeptide binding]; other site 273036003030 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 273036003031 active site 273036003032 metal binding site [ion binding]; metal-binding site 273036003033 homotetramer interface [polypeptide binding]; other site 273036003034 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 273036003035 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 273036003036 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 273036003037 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 273036003038 beta-channel forming cytolysin; Region: hlyII; TIGR01002 273036003039 superantigen-like protein; Reviewed; Region: PRK13350 273036003040 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036003041 superantigen-like protein; Reviewed; Region: PRK13349 273036003042 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036003043 superantigen-like protein; Reviewed; Region: PRK13043 273036003044 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036003045 ornithine carbamoyltransferase; Provisional; Region: PRK04284 273036003046 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 273036003047 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 273036003048 carbamate kinase; Reviewed; Region: PRK12686 273036003049 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 273036003050 putative substrate binding site [chemical binding]; other site 273036003051 nucleotide binding site [chemical binding]; other site 273036003052 nucleotide binding site [chemical binding]; other site 273036003053 homodimer interface [polypeptide binding]; other site 273036003054 Predicted membrane protein [Function unknown]; Region: COG1288 273036003055 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 273036003056 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 273036003057 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 273036003058 gating phenylalanine in ion channel; other site 273036003059 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 273036003060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036003061 motif II; other site 273036003062 hypothetical protein; Provisional; Region: PRK13688 273036003063 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 273036003064 Coenzyme A binding pocket [chemical binding]; other site 273036003065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 273036003066 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 273036003067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 273036003068 MraZ protein; Region: MraZ; pfam02381 273036003069 MraZ protein; Region: MraZ; pfam02381 273036003070 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 273036003071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036003072 S-adenosylmethionine binding site [chemical binding]; other site 273036003073 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 273036003074 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 273036003075 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 273036003076 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 273036003077 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 273036003078 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 273036003079 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 273036003080 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 273036003081 Mg++ binding site [ion binding]; other site 273036003082 putative catalytic motif [active] 273036003083 putative substrate binding site [chemical binding]; other site 273036003084 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 273036003085 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 273036003086 NAD binding site [chemical binding]; other site 273036003087 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 273036003088 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273036003089 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 273036003090 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 273036003091 Cell division protein FtsQ; Region: FtsQ; pfam03799 273036003092 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 273036003093 Cell division protein FtsA; Region: FtsA; smart00842 273036003094 Cell division protein FtsA; Region: FtsA; pfam14450 273036003095 cell division protein FtsZ; Validated; Region: PRK09330 273036003096 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 273036003097 nucleotide binding site [chemical binding]; other site 273036003098 SulA interaction site; other site 273036003099 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 273036003100 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 273036003101 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 273036003102 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273036003103 catalytic residue [active] 273036003104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 273036003105 YGGT family; Region: YGGT; pfam02325 273036003106 conserved hypothetical protein 273036003107 DivIVA protein; Region: DivIVA; pfam05103 273036003108 DivIVA domain; Region: DivI1A_domain; TIGR03544 273036003109 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 273036003110 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 273036003111 HIGH motif; other site 273036003112 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 273036003113 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 273036003114 active site 273036003115 KMSKS motif; other site 273036003116 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 273036003117 tRNA binding surface [nucleotide binding]; other site 273036003118 anticodon binding site; other site 273036003119 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 273036003120 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 273036003121 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 273036003122 active site 273036003123 transposase; 3' end homologous to phage phiPV83 transposase and IS1272 273036003124 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 273036003125 lipoprotein signal peptidase; Provisional; Region: PRK14787 273036003126 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 273036003127 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273036003128 RNA binding surface [nucleotide binding]; other site 273036003129 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 273036003130 active site 273036003131 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 273036003132 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 273036003133 uracil transporter; Provisional; Region: PRK10720 273036003134 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 273036003135 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 273036003136 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 273036003137 dihydroorotase; Validated; Region: pyrC; PRK09357 273036003138 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 273036003139 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 273036003140 active site 273036003141 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 273036003142 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 273036003143 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 273036003144 catalytic site [active] 273036003145 subunit interface [polypeptide binding]; other site 273036003146 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 273036003147 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 273036003148 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 273036003149 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 273036003150 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 273036003151 ATP-grasp domain; Region: ATP-grasp_4; cl17255 273036003152 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 273036003153 IMP binding site; other site 273036003154 dimer interface [polypeptide binding]; other site 273036003155 interdomain contacts; other site 273036003156 partial ornithine binding site; other site 273036003157 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 273036003158 active site 273036003159 dimer interface [polypeptide binding]; other site 273036003160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273036003161 active site 273036003162 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 273036003163 dimer interface [polypeptide binding]; other site 273036003164 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 273036003165 Domain of unknown function (DUF814); Region: DUF814; pfam05670 273036003166 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 273036003167 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 273036003168 catalytic site [active] 273036003169 G-X2-G-X-G-K; other site 273036003170 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 273036003171 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 273036003172 Flavoprotein; Region: Flavoprotein; pfam02441 273036003173 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 273036003174 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 273036003175 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273036003176 ATP binding site [chemical binding]; other site 273036003177 putative Mg++ binding site [ion binding]; other site 273036003178 helicase superfamily c-terminal domain; Region: HELICc; smart00490 273036003179 nucleotide binding region [chemical binding]; other site 273036003180 ATP-binding site [chemical binding]; other site 273036003181 hypothetical protein 273036003182 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 273036003183 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 273036003184 active site 273036003185 catalytic residues [active] 273036003186 metal binding site [ion binding]; metal-binding site 273036003187 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 273036003188 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 273036003189 putative active site [active] 273036003190 substrate binding site [chemical binding]; other site 273036003191 putative cosubstrate binding site; other site 273036003192 catalytic site [active] 273036003193 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 273036003194 substrate binding site [chemical binding]; other site 273036003195 16S rRNA methyltransferase B; Provisional; Region: PRK14902 273036003196 NusB family; Region: NusB; pfam01029 273036003197 putative RNA binding site [nucleotide binding]; other site 273036003198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036003199 S-adenosylmethionine binding site [chemical binding]; other site 273036003200 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 273036003201 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273036003202 FeS/SAM binding site; other site 273036003203 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 273036003204 Protein phosphatase 2C; Region: PP2C; pfam00481 273036003205 active site 273036003206 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 273036003207 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 273036003208 active site 273036003209 ATP binding site [chemical binding]; other site 273036003210 substrate binding site [chemical binding]; other site 273036003211 activation loop (A-loop); other site 273036003212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 273036003213 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 273036003214 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 273036003215 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 273036003216 Predicted GTPases [General function prediction only]; Region: COG1162 273036003217 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 273036003218 RNA binding site [nucleotide binding]; other site 273036003219 homodimer interface [polypeptide binding]; other site 273036003220 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 273036003221 GTPase/Zn-binding domain interface [polypeptide binding]; other site 273036003222 GTP/Mg2+ binding site [chemical binding]; other site 273036003223 G4 box; other site 273036003224 G5 box; other site 273036003225 G1 box; other site 273036003226 Switch I region; other site 273036003227 G2 box; other site 273036003228 G3 box; other site 273036003229 Switch II region; other site 273036003230 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 273036003231 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 273036003232 substrate binding site [chemical binding]; other site 273036003233 hexamer interface [polypeptide binding]; other site 273036003234 metal binding site [ion binding]; metal-binding site 273036003235 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 273036003236 Thiamine pyrophosphokinase; Region: TPK; cd07995 273036003237 active site 273036003238 dimerization interface [polypeptide binding]; other site 273036003239 thiamine binding site [chemical binding]; other site 273036003240 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 273036003241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 273036003242 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 273036003243 DAK2 domain; Region: Dak2; pfam02734 273036003244 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 273036003245 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 273036003246 generic binding surface II; other site 273036003247 ssDNA binding site; other site 273036003248 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273036003249 ATP binding site [chemical binding]; other site 273036003250 putative Mg++ binding site [ion binding]; other site 273036003251 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273036003252 nucleotide binding region [chemical binding]; other site 273036003253 ATP-binding site [chemical binding]; other site 273036003254 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 273036003255 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 273036003256 active site 2 [active] 273036003257 active site 1 [active] 273036003258 putative phosphate acyltransferase; Provisional; Region: PRK05331 273036003259 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 273036003260 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 273036003261 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 273036003262 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 273036003263 NAD(P) binding site [chemical binding]; other site 273036003264 homotetramer interface [polypeptide binding]; other site 273036003265 homodimer interface [polypeptide binding]; other site 273036003266 active site 273036003267 acyl carrier protein; Provisional; Region: acpP; PRK00982 273036003268 ribonuclease III; Reviewed; Region: rnc; PRK00102 273036003269 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 273036003270 dimerization interface [polypeptide binding]; other site 273036003271 active site 273036003272 metal binding site [ion binding]; metal-binding site 273036003273 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 273036003274 dsRNA binding site [nucleotide binding]; other site 273036003275 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 273036003276 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 273036003277 Walker A/P-loop; other site 273036003278 ATP binding site [chemical binding]; other site 273036003279 Q-loop/lid; other site 273036003280 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 273036003281 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 273036003282 ABC transporter signature motif; other site 273036003283 Walker B; other site 273036003284 D-loop; other site 273036003285 H-loop/switch region; other site 273036003286 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 273036003287 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 273036003288 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 273036003289 P loop; other site 273036003290 GTP binding site [chemical binding]; other site 273036003291 putative DNA-binding protein; Validated; Region: PRK00118 273036003292 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 273036003293 signal recognition particle protein; Provisional; Region: PRK10867 273036003294 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 273036003295 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 273036003296 P loop; other site 273036003297 GTP binding site [chemical binding]; other site 273036003298 Signal peptide binding domain; Region: SRP_SPB; pfam02978 273036003299 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 273036003300 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 273036003301 RimM N-terminal domain; Region: RimM; pfam01782 273036003302 PRC-barrel domain; Region: PRC; pfam05239 273036003303 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 273036003304 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 273036003305 membrane protein 273036003306 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 273036003307 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 273036003308 GTP/Mg2+ binding site [chemical binding]; other site 273036003309 G4 box; other site 273036003310 G5 box; other site 273036003311 G1 box; other site 273036003312 Switch I region; other site 273036003313 G2 box; other site 273036003314 G3 box; other site 273036003315 Switch II region; other site 273036003316 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 273036003317 RNA/DNA hybrid binding site [nucleotide binding]; other site 273036003318 active site 273036003319 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 273036003320 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 273036003321 CoA-ligase; Region: Ligase_CoA; pfam00549 273036003322 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 273036003323 CoA binding domain; Region: CoA_binding; pfam02629 273036003324 CoA-ligase; Region: Ligase_CoA; pfam00549 273036003325 DNA protecting protein DprA; Region: dprA; TIGR00732 273036003326 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 273036003327 DNA topoisomerase I; Validated; Region: PRK05582 273036003328 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 273036003329 active site 273036003330 interdomain interaction site; other site 273036003331 putative metal-binding site [ion binding]; other site 273036003332 nucleotide binding site [chemical binding]; other site 273036003333 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 273036003334 domain I; other site 273036003335 DNA binding groove [nucleotide binding] 273036003336 phosphate binding site [ion binding]; other site 273036003337 domain II; other site 273036003338 domain III; other site 273036003339 nucleotide binding site [chemical binding]; other site 273036003340 catalytic site [active] 273036003341 domain IV; other site 273036003342 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 273036003343 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 273036003344 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 273036003345 Glucose inhibited division protein A; Region: GIDA; pfam01134 273036003346 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 273036003347 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 273036003348 active site 273036003349 DNA binding site [nucleotide binding] 273036003350 Int/Topo IB signature motif; other site 273036003351 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 273036003352 active site 273036003353 HslU subunit interaction site [polypeptide binding]; other site 273036003354 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 273036003355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036003356 Walker A motif; other site 273036003357 ATP binding site [chemical binding]; other site 273036003358 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 273036003359 Walker B motif; other site 273036003360 arginine finger; other site 273036003361 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 273036003362 transcriptional repressor CodY; Validated; Region: PRK04158 273036003363 CodY GAF-like domain; Region: CodY; pfam06018 273036003364 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 273036003365 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 273036003366 rRNA interaction site [nucleotide binding]; other site 273036003367 S8 interaction site; other site 273036003368 putative laminin-1 binding site; other site 273036003369 elongation factor Ts; Provisional; Region: tsf; PRK09377 273036003370 UBA/TS-N domain; Region: UBA; pfam00627 273036003371 Elongation factor TS; Region: EF_TS; pfam00889 273036003372 Elongation factor TS; Region: EF_TS; pfam00889 273036003373 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 273036003374 putative nucleotide binding site [chemical binding]; other site 273036003375 uridine monophosphate binding site [chemical binding]; other site 273036003376 homohexameric interface [polypeptide binding]; other site 273036003377 ribosome recycling factor; Reviewed; Region: frr; PRK00083 273036003378 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 273036003379 hinge region; other site 273036003380 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 273036003381 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 273036003382 catalytic residue [active] 273036003383 putative FPP diphosphate binding site; other site 273036003384 putative FPP binding hydrophobic cleft; other site 273036003385 dimer interface [polypeptide binding]; other site 273036003386 putative IPP diphosphate binding site; other site 273036003387 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 273036003388 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 273036003389 RIP metalloprotease RseP; Region: TIGR00054 273036003390 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 273036003391 active site 273036003392 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 273036003393 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 273036003394 protein binding site [polypeptide binding]; other site 273036003395 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 273036003396 putative substrate binding region [chemical binding]; other site 273036003397 prolyl-tRNA synthetase; Provisional; Region: PRK09194 273036003398 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 273036003399 dimer interface [polypeptide binding]; other site 273036003400 motif 1; other site 273036003401 active site 273036003402 motif 2; other site 273036003403 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 273036003404 putative deacylase active site [active] 273036003405 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 273036003406 active site 273036003407 motif 3; other site 273036003408 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 273036003409 anticodon binding site; other site 273036003410 DNA polymerase III PolC; Validated; Region: polC; PRK00448 273036003411 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 273036003412 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 273036003413 generic binding surface II; other site 273036003414 generic binding surface I; other site 273036003415 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 273036003416 active site 273036003417 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 273036003418 active site 273036003419 catalytic site [active] 273036003420 substrate binding site [chemical binding]; other site 273036003421 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 273036003422 ribosome maturation protein RimP; Reviewed; Region: PRK00092 273036003423 Sm and related proteins; Region: Sm_like; cl00259 273036003424 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 273036003425 putative oligomer interface [polypeptide binding]; other site 273036003426 putative RNA binding site [nucleotide binding]; other site 273036003427 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 273036003428 NusA N-terminal domain; Region: NusA_N; pfam08529 273036003429 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 273036003430 RNA binding site [nucleotide binding]; other site 273036003431 homodimer interface [polypeptide binding]; other site 273036003432 NusA-like KH domain; Region: KH_5; pfam13184 273036003433 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 273036003434 G-X-X-G motif; other site 273036003435 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 273036003436 putative RNA binding cleft [nucleotide binding]; other site 273036003437 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 273036003438 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 273036003439 translation initiation factor IF-2; Region: IF-2; TIGR00487 273036003440 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 273036003441 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 273036003442 G1 box; other site 273036003443 putative GEF interaction site [polypeptide binding]; other site 273036003444 GTP/Mg2+ binding site [chemical binding]; other site 273036003445 Switch I region; other site 273036003446 G2 box; other site 273036003447 G3 box; other site 273036003448 Switch II region; other site 273036003449 G4 box; other site 273036003450 G5 box; other site 273036003451 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 273036003452 Translation-initiation factor 2; Region: IF-2; pfam11987 273036003453 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 273036003454 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 273036003455 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 273036003456 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 273036003457 RNA binding site [nucleotide binding]; other site 273036003458 active site 273036003459 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 273036003460 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 273036003461 active site 273036003462 Riboflavin kinase; Region: Flavokinase; smart00904 273036003463 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 273036003464 16S/18S rRNA binding site [nucleotide binding]; other site 273036003465 S13e-L30e interaction site [polypeptide binding]; other site 273036003466 25S rRNA binding site [nucleotide binding]; other site 273036003467 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 273036003468 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 273036003469 RNase E interface [polypeptide binding]; other site 273036003470 trimer interface [polypeptide binding]; other site 273036003471 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 273036003472 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 273036003473 RNase E interface [polypeptide binding]; other site 273036003474 trimer interface [polypeptide binding]; other site 273036003475 active site 273036003476 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 273036003477 putative nucleic acid binding region [nucleotide binding]; other site 273036003478 G-X-X-G motif; other site 273036003479 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 273036003480 RNA binding site [nucleotide binding]; other site 273036003481 domain interface; other site 273036003482 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 273036003483 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 273036003484 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 273036003485 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 273036003486 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 273036003487 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 273036003488 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 273036003489 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 273036003490 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 273036003491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 273036003492 DNA-binding site [nucleotide binding]; DNA binding site 273036003493 UTRA domain; Region: UTRA; pfam07702 273036003494 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 273036003495 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 273036003496 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 273036003497 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 273036003498 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 273036003499 conserved hypothetical protein 273036003500 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 273036003501 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 273036003502 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 273036003503 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273036003504 non-specific DNA binding site [nucleotide binding]; other site 273036003505 salt bridge; other site 273036003506 sequence-specific DNA binding site [nucleotide binding]; other site 273036003507 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 273036003508 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 273036003509 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 273036003510 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 273036003511 putative MPT binding site; other site 273036003512 recombinase A; Provisional; Region: recA; PRK09354 273036003513 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 273036003514 hexamer interface [polypeptide binding]; other site 273036003515 Walker A motif; other site 273036003516 ATP binding site [chemical binding]; other site 273036003517 Walker B motif; other site 273036003518 phosphodiesterase; Provisional; Region: PRK12704 273036003519 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273036003520 Zn2+ binding site [ion binding]; other site 273036003521 Mg2+ binding site [ion binding]; other site 273036003522 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 273036003523 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 273036003524 putative active site [active] 273036003525 metal binding site [ion binding]; metal-binding site 273036003526 homodimer binding site [polypeptide binding]; other site 273036003527 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 273036003528 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 273036003529 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 273036003530 dimer interface [polypeptide binding]; other site 273036003531 PYR/PP interface [polypeptide binding]; other site 273036003532 TPP binding site [chemical binding]; other site 273036003533 substrate binding site [chemical binding]; other site 273036003534 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 273036003535 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 273036003536 TPP-binding site [chemical binding]; other site 273036003537 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 273036003538 Uncharacterized conserved protein [Function unknown]; Region: COG0011 273036003539 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 273036003540 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 273036003541 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273036003542 FeS/SAM binding site; other site 273036003543 TRAM domain; Region: TRAM; pfam01938 273036003544 Predicted membrane protein [Function unknown]; Region: COG4550 273036003545 Predicted membrane protein [Function unknown]; Region: COG4732 273036003546 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 273036003547 MutS domain I; Region: MutS_I; pfam01624 273036003548 MutS domain II; Region: MutS_II; pfam05188 273036003549 MutS domain III; Region: MutS_III; pfam05192 273036003550 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 273036003551 Walker A/P-loop; other site 273036003552 ATP binding site [chemical binding]; other site 273036003553 Q-loop/lid; other site 273036003554 ABC transporter signature motif; other site 273036003555 Walker B; other site 273036003556 D-loop; other site 273036003557 H-loop/switch region; other site 273036003558 DNA mismatch repair protein 273036003559 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 273036003560 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 273036003561 amphipathic channel; other site 273036003562 Asn-Pro-Ala signature motifs; other site 273036003563 glycerol kinase; Provisional; Region: glpK; PRK00047 273036003564 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 273036003565 N- and C-terminal domain interface [polypeptide binding]; other site 273036003566 active site 273036003567 MgATP binding site [chemical binding]; other site 273036003568 catalytic site [active] 273036003569 metal binding site [ion binding]; metal-binding site 273036003570 glycerol binding site [chemical binding]; other site 273036003571 homotetramer interface [polypeptide binding]; other site 273036003572 homodimer interface [polypeptide binding]; other site 273036003573 FBP binding site [chemical binding]; other site 273036003574 protein IIAGlc interface [polypeptide binding]; other site 273036003575 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 273036003576 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 273036003577 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 273036003578 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 273036003579 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 273036003580 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 273036003581 bacterial Hfq-like; Region: Hfq; cd01716 273036003582 hexamer interface [polypeptide binding]; other site 273036003583 Sm1 motif; other site 273036003584 RNA binding site [nucleotide binding]; other site 273036003585 Sm2 motif; other site 273036003586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 273036003587 Transposase; Region: DDE_Tnp_ISL3; pfam01610 273036003588 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 273036003589 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 273036003590 catalytic residues [active] 273036003591 dimer interface [polypeptide binding]; other site 273036003592 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 273036003593 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 273036003594 HflX GTPase family; Region: HflX; cd01878 273036003595 G1 box; other site 273036003596 GTP/Mg2+ binding site [chemical binding]; other site 273036003597 Switch I region; other site 273036003598 G2 box; other site 273036003599 G3 box; other site 273036003600 Switch II region; other site 273036003601 G4 box; other site 273036003602 G5 box; other site 273036003603 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 273036003604 Aluminium resistance protein; Region: Alum_res; pfam06838 273036003605 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 273036003606 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 273036003607 DNA binding residues [nucleotide binding] 273036003608 putative dimer interface [polypeptide binding]; other site 273036003609 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 273036003610 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 273036003611 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 273036003612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 273036003613 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 273036003614 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 273036003615 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 273036003616 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 273036003617 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273036003618 catalytic residue [active] 273036003619 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 273036003620 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 273036003621 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 273036003622 putative active site [active] 273036003623 catalytic site [active] 273036003624 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 273036003625 putative active site [active] 273036003626 catalytic site [active] 273036003627 Staphylococcal nuclease homologues; Region: SNc; smart00318 273036003628 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 273036003629 Catalytic site; other site 273036003630 AAA domain; Region: AAA_11; pfam13086 273036003631 aspartate kinase; Reviewed; Region: PRK09034 273036003632 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 273036003633 putative catalytic residues [active] 273036003634 putative nucleotide binding site [chemical binding]; other site 273036003635 putative aspartate binding site [chemical binding]; other site 273036003636 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 273036003637 allosteric regulatory residue; other site 273036003638 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 273036003639 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 273036003640 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 273036003641 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 273036003642 threonine synthase; Reviewed; Region: PRK06721 273036003643 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 273036003644 homodimer interface [polypeptide binding]; other site 273036003645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036003646 catalytic residue [active] 273036003647 homoserine kinase; Provisional; Region: PRK01212 273036003648 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 273036003649 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 273036003650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036003651 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 273036003652 active site 273036003653 motif I; other site 273036003654 motif II; other site 273036003655 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 273036003656 lysine transporter; Provisional; Region: PRK10836 273036003657 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 273036003658 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 273036003659 tetramer interface [polypeptide binding]; other site 273036003660 heme binding pocket [chemical binding]; other site 273036003661 NADPH binding site [chemical binding]; other site 273036003662 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 273036003663 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 273036003664 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 273036003665 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 273036003666 active site 273036003667 conserved hypothetical protein 273036003668 LexA repressor; Validated; Region: PRK00215 273036003669 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 273036003670 putative DNA binding site [nucleotide binding]; other site 273036003671 putative Zn2+ binding site [ion binding]; other site 273036003672 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 273036003673 Catalytic site [active] 273036003674 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 273036003675 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 273036003676 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 273036003677 TPP-binding site [chemical binding]; other site 273036003678 dimer interface [polypeptide binding]; other site 273036003679 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 273036003680 PYR/PP interface [polypeptide binding]; other site 273036003681 dimer interface [polypeptide binding]; other site 273036003682 TPP binding site [chemical binding]; other site 273036003683 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 273036003684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 273036003685 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 273036003686 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 273036003687 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 273036003688 active site 273036003689 metal binding site [ion binding]; metal-binding site 273036003690 DNA binding site [nucleotide binding] 273036003691 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 273036003692 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 273036003693 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 273036003694 Walker A/P-loop; other site 273036003695 ATP binding site [chemical binding]; other site 273036003696 Q-loop/lid; other site 273036003697 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 273036003698 ABC transporter signature motif; other site 273036003699 Walker B; other site 273036003700 D-loop; other site 273036003701 H-loop/switch region; other site 273036003702 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 273036003703 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 273036003704 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 273036003705 aconitate hydratase; Validated; Region: PRK09277 273036003706 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 273036003707 substrate binding site [chemical binding]; other site 273036003708 ligand binding site [chemical binding]; other site 273036003709 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 273036003710 substrate binding site [chemical binding]; other site 273036003711 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 273036003712 active site 273036003713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 273036003714 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 273036003715 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 273036003716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036003717 ATP binding site [chemical binding]; other site 273036003718 Mg2+ binding site [ion binding]; other site 273036003719 G-X-G motif; other site 273036003720 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 273036003721 anchoring element; other site 273036003722 dimer interface [polypeptide binding]; other site 273036003723 ATP binding site [chemical binding]; other site 273036003724 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 273036003725 active site 273036003726 putative metal-binding site [ion binding]; other site 273036003727 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 273036003728 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 273036003729 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 273036003730 CAP-like domain; other site 273036003731 active site 273036003732 primary dimer interface [polypeptide binding]; other site 273036003733 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273036003734 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 273036003735 amino acid carrier protein; Region: agcS; TIGR00835 273036003736 CAT RNA binding domain; Region: CAT_RBD; smart01061 273036003737 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 273036003738 PRD domain; Region: PRD; pfam00874 273036003739 PRD domain; Region: PRD; pfam00874 273036003740 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 273036003741 Domain of unknown function DUF20; Region: UPF0118; pfam01594 273036003742 Predicted integral membrane protein [Function unknown]; Region: COG0392 273036003743 Uncharacterized conserved protein [Function unknown]; Region: COG2898 273036003744 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 273036003745 methionine sulfoxide reductase A; Provisional; Region: PRK14054 273036003746 Transcriptional regulator [Transcription]; Region: LytR; COG1316 273036003747 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 273036003748 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 273036003749 active site 273036003750 DNA binding site [nucleotide binding] 273036003751 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 273036003752 prephenate dehydrogenase; Validated; Region: PRK06545 273036003753 prephenate dehydrogenase; Validated; Region: PRK08507 273036003754 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 273036003755 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 273036003756 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 273036003757 putative oligomer interface [polypeptide binding]; other site 273036003758 putative active site [active] 273036003759 metal binding site [ion binding]; metal-binding site 273036003760 anthranilate synthase component I; Provisional; Region: PRK13567 273036003761 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 273036003762 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 273036003763 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 273036003764 Glutamine amidotransferase class-I; Region: GATase; pfam00117 273036003765 glutamine binding [chemical binding]; other site 273036003766 catalytic triad [active] 273036003767 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 273036003768 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 273036003769 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 273036003770 active site 273036003771 ribulose/triose binding site [chemical binding]; other site 273036003772 phosphate binding site [ion binding]; other site 273036003773 substrate (anthranilate) binding pocket [chemical binding]; other site 273036003774 product (indole) binding pocket [chemical binding]; other site 273036003775 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 273036003776 active site 273036003777 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 273036003778 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 273036003779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036003780 catalytic residue [active] 273036003781 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 273036003782 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 273036003783 substrate binding site [chemical binding]; other site 273036003784 active site 273036003785 catalytic residues [active] 273036003786 heterodimer interface [polypeptide binding]; other site 273036003787 FemAB family; Region: FemAB; pfam02388 273036003788 FlxA-like protein; Region: FlxA; pfam14282 273036003789 FemAB family; Region: FemAB; pfam02388 273036003790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036003791 active site 273036003792 motif I; other site 273036003793 motif II; other site 273036003794 SWIM zinc finger; Region: SWIM; pfam04434 273036003795 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 273036003796 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273036003797 Walker A/P-loop; other site 273036003798 ATP binding site [chemical binding]; other site 273036003799 Q-loop/lid; other site 273036003800 ABC transporter signature motif; other site 273036003801 Walker B; other site 273036003802 D-loop; other site 273036003803 H-loop/switch region; other site 273036003804 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273036003805 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 273036003806 Walker A/P-loop; other site 273036003807 ATP binding site [chemical binding]; other site 273036003808 Q-loop/lid; other site 273036003809 ABC transporter signature motif; other site 273036003810 Walker B; other site 273036003811 D-loop; other site 273036003812 H-loop/switch region; other site 273036003813 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 273036003814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036003815 dimer interface [polypeptide binding]; other site 273036003816 conserved gate region; other site 273036003817 putative PBP binding loops; other site 273036003818 ABC-ATPase subunit interface; other site 273036003819 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 273036003820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036003821 dimer interface [polypeptide binding]; other site 273036003822 conserved gate region; other site 273036003823 putative PBP binding loops; other site 273036003824 ABC-ATPase subunit interface; other site 273036003825 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 273036003826 oligoendopeptidase F; Region: pepF; TIGR00181 273036003827 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 273036003828 active site 273036003829 Zn binding site [ion binding]; other site 273036003830 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 273036003831 PhoU domain; Region: PhoU; pfam01895 273036003832 PhoU domain; Region: PhoU; pfam01895 273036003833 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 273036003834 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 273036003835 Walker A/P-loop; other site 273036003836 ATP binding site [chemical binding]; other site 273036003837 Q-loop/lid; other site 273036003838 ABC transporter signature motif; other site 273036003839 Walker B; other site 273036003840 D-loop; other site 273036003841 H-loop/switch region; other site 273036003842 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 273036003843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036003844 dimer interface [polypeptide binding]; other site 273036003845 conserved gate region; other site 273036003846 putative PBP binding loops; other site 273036003847 ABC-ATPase subunit interface; other site 273036003848 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 273036003849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036003850 dimer interface [polypeptide binding]; other site 273036003851 conserved gate region; other site 273036003852 ABC-ATPase subunit interface; other site 273036003853 phosphate binding protein; Region: ptsS_2; TIGR02136 273036003854 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 273036003855 S1 domain; Region: S1_2; pfam13509 273036003856 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 273036003857 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273036003858 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273036003859 ABC transporter; Region: ABC_tran_2; pfam12848 273036003860 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273036003861 aspartate kinase; Reviewed; Region: PRK06635 273036003862 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 273036003863 putative nucleotide binding site [chemical binding]; other site 273036003864 putative catalytic residues [active] 273036003865 putative Mg ion binding site [ion binding]; other site 273036003866 putative aspartate binding site [chemical binding]; other site 273036003867 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 273036003868 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 273036003869 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 273036003870 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 273036003871 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 273036003872 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 273036003873 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 273036003874 dimer interface [polypeptide binding]; other site 273036003875 active site 273036003876 catalytic residue [active] 273036003877 dihydrodipicolinate reductase; Provisional; Region: PRK00048 273036003878 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 273036003879 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 273036003880 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 273036003881 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 273036003882 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 273036003883 trimer interface [polypeptide binding]; other site 273036003884 active site 273036003885 substrate binding site [chemical binding]; other site 273036003886 CoA binding site [chemical binding]; other site 273036003887 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 273036003888 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 273036003889 metal binding site [ion binding]; metal-binding site 273036003890 dimer interface [polypeptide binding]; other site 273036003891 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 273036003892 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 273036003893 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273036003894 catalytic residue [active] 273036003895 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 273036003896 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 273036003897 active site 273036003898 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273036003899 substrate binding site [chemical binding]; other site 273036003900 catalytic residues [active] 273036003901 dimer interface [polypeptide binding]; other site 273036003902 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 273036003903 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 273036003904 DNA-binding site [nucleotide binding]; DNA binding site 273036003905 RNA-binding motif; other site 273036003906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 273036003907 acylphosphatase; Provisional; Region: PRK14431 273036003908 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 273036003909 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 273036003910 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 273036003911 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 273036003912 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 273036003913 metal ion-dependent adhesion site (MIDAS); other site 273036003914 MoxR-like ATPases [General function prediction only]; Region: COG0714 273036003915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036003916 Walker A motif; other site 273036003917 ATP binding site [chemical binding]; other site 273036003918 Walker B motif; other site 273036003919 arginine finger; other site 273036003920 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 273036003921 active site 273036003922 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 273036003923 active site 273036003924 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 273036003925 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 273036003926 E3 interaction surface; other site 273036003927 lipoyl attachment site [posttranslational modification]; other site 273036003928 e3 binding domain; Region: E3_binding; pfam02817 273036003929 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 273036003930 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 273036003931 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 273036003932 TPP-binding site [chemical binding]; other site 273036003933 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 273036003934 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 273036003935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 273036003936 HAMP domain; Region: HAMP; pfam00672 273036003937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273036003938 dimer interface [polypeptide binding]; other site 273036003939 phosphorylation site [posttranslational modification] 273036003940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036003941 ATP binding site [chemical binding]; other site 273036003942 Mg2+ binding site [ion binding]; other site 273036003943 G-X-G motif; other site 273036003944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273036003945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273036003946 active site 273036003947 phosphorylation site [posttranslational modification] 273036003948 intermolecular recognition site; other site 273036003949 dimerization interface [polypeptide binding]; other site 273036003950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273036003951 DNA binding site [nucleotide binding] 273036003952 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 273036003953 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 273036003954 active site 273036003955 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 273036003956 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 273036003957 active site 273036003958 homodimer interface [polypeptide binding]; other site 273036003959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036003960 Coenzyme A binding pocket [chemical binding]; other site 273036003961 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 273036003962 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 273036003963 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 273036003964 protein binding site [polypeptide binding]; other site 273036003965 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 273036003966 Catalytic dyad [active] 273036003967 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 273036003968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 273036003969 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 273036003970 HPr interaction site; other site 273036003971 glycerol kinase (GK) interaction site [polypeptide binding]; other site 273036003972 active site 273036003973 phosphorylation site [posttranslational modification] 273036003974 methionine sulfoxide reductase B; Provisional; Region: PRK00222 273036003975 SelR domain; Region: SelR; pfam01641 273036003976 methionine sulfoxide reductase A; Provisional; Region: PRK13014 273036003977 EDD domain protein, DegV family; Region: DegV; TIGR00762 273036003978 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 273036003979 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 273036003980 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 273036003981 folate binding site [chemical binding]; other site 273036003982 NADP+ binding site [chemical binding]; other site 273036003983 thymidylate synthase; Region: thym_sym; TIGR03284 273036003984 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 273036003985 dimerization interface [polypeptide binding]; other site 273036003986 active site 273036003987 Disulphide isomerase; Region: Disulph_isomer; pfam06491 273036003988 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 273036003989 Virulence factor; Region: Virulence_fact; pfam13769 273036003990 HEAT repeats; Region: HEAT_2; pfam13646 273036003991 HEAT repeat; Region: HEAT; pfam02985 273036003992 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 273036003993 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 273036003994 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 273036003995 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 273036003996 RNA/DNA hybrid binding site [nucleotide binding]; other site 273036003997 active site 273036003998 GA module; Region: GA; smart00844 273036003999 GA module; Region: GA; smart00844 273036004000 GA module; Region: GA; smart00844 273036004001 GA module; Region: GA; smart00844 273036004002 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 273036004003 GA module; Region: GA; smart00844 273036004004 GA module; Region: GA; smart00844 273036004005 GA module; Region: GA; smart00844 273036004006 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 273036004007 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 273036004008 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 273036004009 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 273036004010 GA module; Region: GA; smart00844 273036004011 GA module; Region: GA; smart00844 273036004012 GA module; Region: GA; smart00844 273036004013 GA module; Region: GA; smart00844 273036004014 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 273036004015 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 273036004016 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 273036004017 hypothetical protein 273036004018 Replication protein; Region: Rep_1; cl02412 273036004019 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 273036004020 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 273036004021 NADP binding site [chemical binding]; other site 273036004022 dimer interface [polypeptide binding]; other site 273036004023 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 273036004024 MarR family; Region: MarR_2; pfam12802 273036004025 multiple promoter invertase; Provisional; Region: mpi; PRK13413 273036004026 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 273036004027 catalytic residues [active] 273036004028 catalytic nucleophile [active] 273036004029 Presynaptic Site I dimer interface [polypeptide binding]; other site 273036004030 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 273036004031 Synaptic Flat tetramer interface [polypeptide binding]; other site 273036004032 Synaptic Site I dimer interface [polypeptide binding]; other site 273036004033 DNA binding site [nucleotide binding] 273036004034 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 273036004035 DNA-binding interface [nucleotide binding]; DNA binding site 273036004036 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 273036004037 Integrase core domain; Region: rve; pfam00665 273036004038 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 273036004039 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 273036004040 L-type amino acid transporter; Region: 2A0308; TIGR00911 273036004041 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 273036004042 tetramer interface [polypeptide binding]; other site 273036004043 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 273036004044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036004045 catalytic residue [active] 273036004046 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 273036004047 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 273036004048 hexamer interface [polypeptide binding]; other site 273036004049 ligand binding site [chemical binding]; other site 273036004050 putative active site [active] 273036004051 NAD(P) binding site [chemical binding]; other site 273036004052 5'-3' exonuclease; Region: 53EXOc; smart00475 273036004053 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 273036004054 active site 273036004055 metal binding site 1 [ion binding]; metal-binding site 273036004056 putative 5' ssDNA interaction site; other site 273036004057 metal binding site 3; metal-binding site 273036004058 metal binding site 2 [ion binding]; metal-binding site 273036004059 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 273036004060 putative DNA binding site [nucleotide binding]; other site 273036004061 putative metal binding site [ion binding]; other site 273036004062 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 273036004063 Dynamin family; Region: Dynamin_N; pfam00350 273036004064 G1 box; other site 273036004065 GTP/Mg2+ binding site [chemical binding]; other site 273036004066 G2 box; other site 273036004067 Switch I region; other site 273036004068 G3 box; other site 273036004069 Switch II region; other site 273036004070 G4 box; other site 273036004071 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 273036004072 Dynamin family; Region: Dynamin_N; pfam00350 273036004073 G1 box; other site 273036004074 GTP/Mg2+ binding site [chemical binding]; other site 273036004075 G2 box; other site 273036004076 Switch I region; other site 273036004077 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 273036004078 Switch I region; other site 273036004079 G3 box; other site 273036004080 Switch II region; other site 273036004081 GTP/Mg2+ binding site [chemical binding]; other site 273036004082 G4 box; other site 273036004083 G5 box; other site 273036004084 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 273036004085 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 273036004086 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 273036004087 Cobalt transport protein component CbiN; Region: CbiN; cl00842 273036004088 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 273036004089 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 273036004090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 273036004091 cell division protein GpsB; Provisional; Region: PRK14127 273036004092 DivIVA domain; Region: DivI1A_domain; TIGR03544 273036004093 hypothetical protein; Provisional; Region: PRK13660 273036004094 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 273036004095 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 273036004096 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 273036004097 Transglycosylase; Region: Transgly; pfam00912 273036004098 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 273036004099 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 273036004100 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 273036004101 minor groove reading motif; other site 273036004102 helix-hairpin-helix signature motif; other site 273036004103 substrate binding pocket [chemical binding]; other site 273036004104 active site 273036004105 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 273036004106 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 273036004107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 273036004108 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 273036004109 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 273036004110 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 273036004111 putative dimer interface [polypeptide binding]; other site 273036004112 putative anticodon binding site; other site 273036004113 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 273036004114 homodimer interface [polypeptide binding]; other site 273036004115 motif 1; other site 273036004116 motif 2; other site 273036004117 active site 273036004118 motif 3; other site 273036004119 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 273036004120 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 273036004121 active site 273036004122 catalytic site [active] 273036004123 substrate binding site [chemical binding]; other site 273036004124 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 273036004125 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 273036004126 Biotin operon repressor [Transcription]; Region: BirA; COG1654 273036004127 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 273036004128 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 273036004129 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 273036004130 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 273036004131 active site 273036004132 NTP binding site [chemical binding]; other site 273036004133 metal binding triad [ion binding]; metal-binding site 273036004134 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 273036004135 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 273036004136 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 273036004137 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 273036004138 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 273036004139 homodimer interface [polypeptide binding]; other site 273036004140 metal binding site [ion binding]; metal-binding site 273036004141 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 273036004142 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 273036004143 Uncharacterized conserved protein [Function unknown]; Region: COG5582 273036004144 UPF0302 domain; Region: UPF0302; pfam08864 273036004145 A short protein domain of unknown function; Region: IDEAL; smart00914 273036004146 TPR repeat; Region: TPR_11; pfam13414 273036004147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273036004148 binding surface 273036004149 TPR motif; other site 273036004150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273036004151 TPR motif; other site 273036004152 binding surface 273036004153 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 273036004154 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 273036004155 hinge; other site 273036004156 active site 273036004157 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 273036004158 active site 273036004159 NAD binding site [chemical binding]; other site 273036004160 metal binding site [ion binding]; metal-binding site 273036004161 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 273036004162 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 273036004163 Tetramer interface [polypeptide binding]; other site 273036004164 active site 273036004165 FMN-binding site [chemical binding]; other site 273036004166 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 273036004167 active site 273036004168 multimer interface [polypeptide binding]; other site 273036004169 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 273036004170 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 273036004171 substrate binding pocket [chemical binding]; other site 273036004172 chain length determination region; other site 273036004173 substrate-Mg2+ binding site; other site 273036004174 catalytic residues [active] 273036004175 aspartate-rich region 1; other site 273036004176 active site lid residues [active] 273036004177 aspartate-rich region 2; other site 273036004178 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 273036004179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036004180 S-adenosylmethionine binding site [chemical binding]; other site 273036004181 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 273036004182 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 273036004183 IHF dimer interface [polypeptide binding]; other site 273036004184 IHF - DNA interface [nucleotide binding]; other site 273036004185 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 273036004186 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 273036004187 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 273036004188 GTP-ase protein 273036004189 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 273036004190 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 273036004191 RNA binding site [nucleotide binding]; other site 273036004192 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 273036004193 RNA binding site [nucleotide binding]; other site 273036004194 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 273036004195 RNA binding site [nucleotide binding]; other site 273036004196 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 273036004197 RNA binding site [nucleotide binding]; other site 273036004198 cytidylate kinase; Provisional; Region: cmk; PRK00023 273036004199 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 273036004200 CMP-binding site; other site 273036004201 The sites determining sugar specificity; other site 273036004202 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 273036004203 active site 273036004204 homotetramer interface [polypeptide binding]; other site 273036004205 homodimer interface [polypeptide binding]; other site 273036004206 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 273036004207 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 273036004208 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273036004209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 273036004210 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 273036004211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273036004212 ATP binding site [chemical binding]; other site 273036004213 putative Mg++ binding site [ion binding]; other site 273036004214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273036004215 nucleotide binding region [chemical binding]; other site 273036004216 ATP-binding site [chemical binding]; other site 273036004217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 273036004218 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 273036004219 Predicted membrane protein [Function unknown]; Region: COG3601 273036004220 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 273036004221 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 273036004222 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 273036004223 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273036004224 dimerization interface [polypeptide binding]; other site 273036004225 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 273036004226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273036004227 dimer interface [polypeptide binding]; other site 273036004228 phosphorylation site [posttranslational modification] 273036004229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036004230 ATP binding site [chemical binding]; other site 273036004231 Mg2+ binding site [ion binding]; other site 273036004232 G-X-G motif; other site 273036004233 staphylococcal respiratory response protein A 273036004234 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 273036004235 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273036004236 RNA binding surface [nucleotide binding]; other site 273036004237 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 273036004238 active site 273036004239 conserved hypothetical protein 273036004240 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 273036004241 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 273036004242 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 273036004243 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 273036004244 active site 273036004245 Int/Topo IB signature motif; other site 273036004246 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 273036004247 metal binding site 2 [ion binding]; metal-binding site 273036004248 putative DNA binding helix; other site 273036004249 metal binding site 1 [ion binding]; metal-binding site 273036004250 dimer interface [polypeptide binding]; other site 273036004251 structural Zn2+ binding site [ion binding]; other site 273036004252 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 273036004253 dimer interface [polypeptide binding]; other site 273036004254 ADP-ribose binding site [chemical binding]; other site 273036004255 active site 273036004256 nudix motif; other site 273036004257 metal binding site [ion binding]; metal-binding site 273036004258 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273036004259 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 273036004260 active site 273036004261 catalytic tetrad [active] 273036004262 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 273036004263 classical (c) SDRs; Region: SDR_c; cd05233 273036004264 NAD(P) binding site [chemical binding]; other site 273036004265 active site 273036004266 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 273036004267 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 273036004268 ribonuclease Z; Region: RNase_Z; TIGR02651 273036004269 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 273036004270 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 273036004271 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 273036004272 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 273036004273 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 273036004274 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 273036004275 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 273036004276 Ca binding site [ion binding]; other site 273036004277 active site 273036004278 catalytic site [active] 273036004279 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273036004280 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273036004281 DNA binding site [nucleotide binding] 273036004282 domain linker motif; other site 273036004283 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 273036004284 putative ligand binding site [chemical binding]; other site 273036004285 putative dimerization interface [polypeptide binding]; other site 273036004286 possible prophage 273036004287 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 273036004288 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 273036004289 CAAX protease self-immunity; Region: Abi; pfam02517 273036004290 YcaO-like family; Region: YcaO; pfam02624 273036004291 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 273036004292 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 273036004293 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 273036004294 putative FMN binding site [chemical binding]; other site 273036004295 FMN binding site [chemical binding]; other site 273036004296 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 273036004297 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 273036004298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273036004299 Walker A/P-loop; other site 273036004300 ATP binding site [chemical binding]; other site 273036004301 Q-loop/lid; other site 273036004302 ABC transporter signature motif; other site 273036004303 Walker B; other site 273036004304 D-loop; other site 273036004305 H-loop/switch region; other site 273036004306 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 273036004307 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 273036004308 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 273036004309 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 273036004310 peptidase T-like protein; Region: PepT-like; TIGR01883 273036004311 metal binding site [ion binding]; metal-binding site 273036004312 putative dimer interface [polypeptide binding]; other site 273036004313 Predicted membrane protein [Function unknown]; Region: COG4129 273036004314 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 273036004315 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 273036004316 Disulphide isomerase; Region: Disulph_isomer; pfam06491 273036004317 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 273036004318 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 273036004319 E3 interaction surface; other site 273036004320 lipoyl attachment site [posttranslational modification]; other site 273036004321 e3 binding domain; Region: E3_binding; pfam02817 273036004322 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 273036004323 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 273036004324 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 273036004325 alpha subunit interface [polypeptide binding]; other site 273036004326 TPP binding site [chemical binding]; other site 273036004327 heterodimer interface [polypeptide binding]; other site 273036004328 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 273036004329 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 273036004330 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 273036004331 tetramer interface [polypeptide binding]; other site 273036004332 TPP-binding site [chemical binding]; other site 273036004333 heterodimer interface [polypeptide binding]; other site 273036004334 phosphorylation loop region [posttranslational modification] 273036004335 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 273036004336 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 273036004337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273036004338 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 273036004339 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 273036004340 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 273036004341 Walker A/P-loop; other site 273036004342 ATP binding site [chemical binding]; other site 273036004343 Q-loop/lid; other site 273036004344 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 273036004345 ABC transporter signature motif; other site 273036004346 Walker B; other site 273036004347 D-loop; other site 273036004348 H-loop/switch region; other site 273036004349 arginine repressor; Provisional; Region: PRK04280 273036004350 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 273036004351 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 273036004352 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 273036004353 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 273036004354 substrate binding pocket [chemical binding]; other site 273036004355 chain length determination region; other site 273036004356 substrate-Mg2+ binding site; other site 273036004357 catalytic residues [active] 273036004358 aspartate-rich region 1; other site 273036004359 active site lid residues [active] 273036004360 aspartate-rich region 2; other site 273036004361 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 273036004362 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 273036004363 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 273036004364 generic binding surface II; other site 273036004365 generic binding surface I; other site 273036004366 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 273036004367 putative RNA binding site [nucleotide binding]; other site 273036004368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 273036004369 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 273036004370 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 273036004371 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 273036004372 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 273036004373 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 273036004374 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 273036004375 carboxyltransferase (CT) interaction site; other site 273036004376 biotinylation site [posttranslational modification]; other site 273036004377 elongation factor P; Validated; Region: PRK00529 273036004378 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 273036004379 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 273036004380 RNA binding site [nucleotide binding]; other site 273036004381 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 273036004382 RNA binding site [nucleotide binding]; other site 273036004383 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 273036004384 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 273036004385 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 273036004386 active site 273036004387 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 273036004388 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 273036004389 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 273036004390 active site residue [active] 273036004391 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 273036004392 tetramer interface [polypeptide binding]; other site 273036004393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036004394 catalytic residue [active] 273036004395 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 273036004396 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 273036004397 tetramer interface [polypeptide binding]; other site 273036004398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036004399 catalytic residue [active] 273036004400 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 273036004401 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 273036004402 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 273036004403 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 273036004404 ADP binding site [chemical binding]; other site 273036004405 magnesium binding site [ion binding]; other site 273036004406 putative shikimate binding site; other site 273036004407 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 273036004408 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 273036004409 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 273036004410 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 273036004411 conserved hypothetical protein 273036004412 Type II/IV secretion system protein; Region: T2SE; pfam00437 273036004413 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 273036004414 Walker A motif; other site 273036004415 ATP binding site [chemical binding]; other site 273036004416 Walker B motif; other site 273036004417 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 273036004418 Uncharacterized conserved protein [Function unknown]; Region: COG0011 273036004419 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 273036004420 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 273036004421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 273036004422 Rhomboid family; Region: Rhomboid; pfam01694 273036004423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273036004424 binding surface 273036004425 TPR motif; other site 273036004426 Tetratricopeptide repeat; Region: TPR_16; pfam13432 273036004427 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 273036004428 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 273036004429 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 273036004430 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 273036004431 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 273036004432 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 273036004433 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 273036004434 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 273036004435 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 273036004436 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 273036004437 metal binding site 2 [ion binding]; metal-binding site 273036004438 putative DNA binding helix; other site 273036004439 metal binding site 1 [ion binding]; metal-binding site 273036004440 dimer interface [polypeptide binding]; other site 273036004441 structural Zn2+ binding site [ion binding]; other site 273036004442 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 273036004443 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273036004444 ABC-ATPase subunit interface; other site 273036004445 dimer interface [polypeptide binding]; other site 273036004446 putative PBP binding regions; other site 273036004447 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 273036004448 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 273036004449 endonuclease IV; Provisional; Region: PRK01060 273036004450 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 273036004451 AP (apurinic/apyrimidinic) site pocket; other site 273036004452 DNA interaction; other site 273036004453 Metal-binding active site; metal-binding site 273036004454 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 273036004455 DEAD-like helicases superfamily; Region: DEXDc; smart00487 273036004456 ATP binding site [chemical binding]; other site 273036004457 Mg++ binding site [ion binding]; other site 273036004458 motif III; other site 273036004459 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273036004460 nucleotide binding region [chemical binding]; other site 273036004461 ATP-binding site [chemical binding]; other site 273036004462 Uncharacterized conserved protein [Function unknown]; Region: COG0327 273036004463 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 273036004464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 273036004465 Uncharacterized conserved protein [Function unknown]; Region: COG0327 273036004466 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 273036004467 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 273036004468 Family of unknown function (DUF633); Region: DUF633; pfam04816 273036004469 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 273036004470 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 273036004471 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 273036004472 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273036004473 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 273036004474 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273036004475 DNA binding residues [nucleotide binding] 273036004476 DNA primase, catalytic core; Region: dnaG; TIGR01391 273036004477 CHC2 zinc finger; Region: zf-CHC2; pfam01807 273036004478 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 273036004479 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 273036004480 active site 273036004481 metal binding site [ion binding]; metal-binding site 273036004482 interdomain interaction site; other site 273036004483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 273036004484 HTH domain; Region: HTH_11; cl17392 273036004485 FOG: CBS domain [General function prediction only]; Region: COG0517 273036004486 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 273036004487 glycyl-tRNA synthetase; Provisional; Region: PRK04173 273036004488 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 273036004489 motif 1; other site 273036004490 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 273036004491 active site 273036004492 motif 2; other site 273036004493 motif 3; other site 273036004494 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 273036004495 anticodon binding site; other site 273036004496 DNA repair protein RecO; Region: reco; TIGR00613 273036004497 Recombination protein O N terminal; Region: RecO_N; pfam11967 273036004498 Recombination protein O C terminal; Region: RecO_C; pfam02565 273036004499 GTPase Era; Reviewed; Region: era; PRK00089 273036004500 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 273036004501 G1 box; other site 273036004502 GTP/Mg2+ binding site [chemical binding]; other site 273036004503 Switch I region; other site 273036004504 G2 box; other site 273036004505 Switch II region; other site 273036004506 G3 box; other site 273036004507 G4 box; other site 273036004508 G5 box; other site 273036004509 KH domain; Region: KH_2; pfam07650 273036004510 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 273036004511 active site 273036004512 catalytic motif [active] 273036004513 Zn binding site [ion binding]; other site 273036004514 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 273036004515 metal-binding heat shock protein; Provisional; Region: PRK00016 273036004516 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 273036004517 PhoH-like protein; Region: PhoH; pfam02562 273036004518 hypothetical protein; Provisional; Region: PRK13665 273036004519 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 273036004520 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 273036004521 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 273036004522 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 273036004523 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273036004524 FeS/SAM binding site; other site 273036004525 TRAM domain; Region: TRAM; cl01282 273036004526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 273036004527 RNA methyltransferase, RsmE family; Region: TIGR00046 273036004528 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 273036004529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036004530 S-adenosylmethionine binding site [chemical binding]; other site 273036004531 chaperone protein DnaJ; Provisional; Region: PRK14280 273036004532 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 273036004533 HSP70 interaction site [polypeptide binding]; other site 273036004534 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 273036004535 substrate binding site [polypeptide binding]; other site 273036004536 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 273036004537 Zn binding sites [ion binding]; other site 273036004538 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 273036004539 dimer interface [polypeptide binding]; other site 273036004540 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 273036004541 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 273036004542 nucleotide binding site [chemical binding]; other site 273036004543 NEF interaction site [polypeptide binding]; other site 273036004544 SBD interface [polypeptide binding]; other site 273036004545 heat shock protein GrpE; Provisional; Region: PRK14140 273036004546 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 273036004547 dimer interface [polypeptide binding]; other site 273036004548 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 273036004549 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 273036004550 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 273036004551 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 273036004552 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273036004553 FeS/SAM binding site; other site 273036004554 HemN C-terminal domain; Region: HemN_C; pfam06969 273036004555 GTP-binding protein LepA; Provisional; Region: PRK05433 273036004556 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 273036004557 G1 box; other site 273036004558 putative GEF interaction site [polypeptide binding]; other site 273036004559 GTP/Mg2+ binding site [chemical binding]; other site 273036004560 Switch I region; other site 273036004561 G2 box; other site 273036004562 G3 box; other site 273036004563 Switch II region; other site 273036004564 G4 box; other site 273036004565 G5 box; other site 273036004566 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 273036004567 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 273036004568 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 273036004569 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 273036004570 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 273036004571 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 273036004572 probable membrane protein 273036004573 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 273036004574 catalytic motif [active] 273036004575 Zn binding site [ion binding]; other site 273036004576 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 273036004577 Helix-hairpin-helix motif; Region: HHH; pfam00633 273036004578 Methyltransferase domain; Region: Methyltransf_31; pfam13847 273036004579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036004580 S-adenosylmethionine binding site [chemical binding]; other site 273036004581 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 273036004582 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273036004583 Zn2+ binding site [ion binding]; other site 273036004584 Mg2+ binding site [ion binding]; other site 273036004585 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 273036004586 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 273036004587 active site 273036004588 (T/H)XGH motif; other site 273036004589 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 273036004590 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 273036004591 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 273036004592 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 273036004593 shikimate binding site; other site 273036004594 NAD(P) binding site [chemical binding]; other site 273036004595 GTPase YqeH; Provisional; Region: PRK13796 273036004596 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 273036004597 GTP/Mg2+ binding site [chemical binding]; other site 273036004598 G4 box; other site 273036004599 G5 box; other site 273036004600 G1 box; other site 273036004601 Switch I region; other site 273036004602 G2 box; other site 273036004603 G3 box; other site 273036004604 Switch II region; other site 273036004605 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 273036004606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036004607 active site 273036004608 motif I; other site 273036004609 motif II; other site 273036004610 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 273036004611 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 273036004612 staphylococcal enterotoxin 273036004613 Fic family protein [Function unknown]; Region: COG3177 273036004614 Fic/DOC family; Region: Fic; pfam02661 273036004615 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 273036004616 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 273036004617 putative active site [active] 273036004618 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 273036004619 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 273036004620 ATP-grasp domain; Region: ATP-grasp_4; cl17255 273036004621 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 273036004622 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 273036004623 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 273036004624 carboxyltransferase (CT) interaction site; other site 273036004625 biotinylation site [posttranslational modification]; other site 273036004626 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 273036004627 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 273036004628 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 273036004629 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 273036004630 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 273036004631 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 273036004632 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 273036004633 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 273036004634 Sugar specificity; other site 273036004635 Pyrimidine base specificity; other site 273036004636 ATP-binding site [chemical binding]; other site 273036004637 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 273036004638 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 273036004639 Peptidase family U32; Region: Peptidase_U32; pfam01136 273036004640 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 273036004641 Peptidase family U32; Region: Peptidase_U32; pfam01136 273036004642 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 273036004643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036004644 S-adenosylmethionine binding site [chemical binding]; other site 273036004645 hypothetical protein; Provisional; Region: PRK13678 273036004646 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 273036004647 hypothetical protein; Provisional; Region: PRK05473 273036004648 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 273036004649 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 273036004650 motif 1; other site 273036004651 active site 273036004652 motif 2; other site 273036004653 motif 3; other site 273036004654 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 273036004655 DHHA1 domain; Region: DHHA1; pfam02272 273036004656 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 273036004657 AAA domain; Region: AAA_30; pfam13604 273036004658 Family description; Region: UvrD_C_2; pfam13538 273036004659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273036004660 binding surface 273036004661 TPR motif; other site 273036004662 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 273036004663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273036004664 binding surface 273036004665 TPR motif; other site 273036004666 TPR repeat; Region: TPR_11; pfam13414 273036004667 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 273036004668 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 273036004669 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 273036004670 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 273036004671 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273036004672 catalytic residue [active] 273036004673 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 273036004674 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 273036004675 Predicted transcriptional regulator [Transcription]; Region: COG1959 273036004676 Transcriptional regulator; Region: Rrf2; pfam02082 273036004677 recombination factor protein RarA; Reviewed; Region: PRK13342 273036004678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036004679 Walker A motif; other site 273036004680 ATP binding site [chemical binding]; other site 273036004681 Walker B motif; other site 273036004682 arginine finger; other site 273036004683 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 273036004684 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 273036004685 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 273036004686 putative ATP binding site [chemical binding]; other site 273036004687 putative substrate interface [chemical binding]; other site 273036004688 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 273036004689 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 273036004690 dimer interface [polypeptide binding]; other site 273036004691 anticodon binding site; other site 273036004692 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 273036004693 homodimer interface [polypeptide binding]; other site 273036004694 motif 1; other site 273036004695 active site 273036004696 motif 2; other site 273036004697 GAD domain; Region: GAD; pfam02938 273036004698 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 273036004699 motif 3; other site 273036004700 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 273036004701 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 273036004702 dimer interface [polypeptide binding]; other site 273036004703 motif 1; other site 273036004704 active site 273036004705 motif 2; other site 273036004706 motif 3; other site 273036004707 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 273036004708 anticodon binding site; other site 273036004709 Bacterial SH3 domain homologues; Region: SH3b; smart00287 273036004710 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 273036004711 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 273036004712 active site 273036004713 metal binding site [ion binding]; metal-binding site 273036004714 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 273036004715 putative active site [active] 273036004716 dimerization interface [polypeptide binding]; other site 273036004717 putative tRNAtyr binding site [nucleotide binding]; other site 273036004718 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 273036004719 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273036004720 Zn2+ binding site [ion binding]; other site 273036004721 Mg2+ binding site [ion binding]; other site 273036004722 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 273036004723 synthetase active site [active] 273036004724 NTP binding site [chemical binding]; other site 273036004725 metal binding site [ion binding]; metal-binding site 273036004726 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 273036004727 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 273036004728 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273036004729 active site 273036004730 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 273036004731 DHH family; Region: DHH; pfam01368 273036004732 DHHA1 domain; Region: DHHA1; pfam02272 273036004733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 273036004734 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 273036004735 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 273036004736 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 273036004737 Protein export membrane protein; Region: SecD_SecF; pfam02355 273036004738 Preprotein translocase subunit; Region: YajC; pfam02699 273036004739 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 273036004740 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 273036004741 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 273036004742 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 273036004743 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 273036004744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036004745 Walker A motif; other site 273036004746 ATP binding site [chemical binding]; other site 273036004747 Walker B motif; other site 273036004748 arginine finger; other site 273036004749 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 273036004750 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 273036004751 RuvA N terminal domain; Region: RuvA_N; pfam01330 273036004752 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 273036004753 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 273036004754 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 273036004755 GTPase CgtA; Reviewed; Region: obgE; PRK12297 273036004756 GTP1/OBG; Region: GTP1_OBG; pfam01018 273036004757 Obg GTPase; Region: Obg; cd01898 273036004758 G1 box; other site 273036004759 GTP/Mg2+ binding site [chemical binding]; other site 273036004760 Switch I region; other site 273036004761 G2 box; other site 273036004762 G3 box; other site 273036004763 Switch II region; other site 273036004764 G4 box; other site 273036004765 G5 box; other site 273036004766 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 273036004767 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 273036004768 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 273036004769 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 273036004770 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 273036004771 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 273036004772 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 273036004773 rod shape-determining protein MreC; Region: MreC; pfam04085 273036004774 hypothetical protein; Reviewed; Region: PRK00024 273036004775 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 273036004776 MPN+ (JAMM) motif; other site 273036004777 Zinc-binding site [ion binding]; other site 273036004778 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 273036004779 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 273036004780 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 273036004781 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 273036004782 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273036004783 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 273036004784 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 273036004785 active site 273036004786 HIGH motif; other site 273036004787 nucleotide binding site [chemical binding]; other site 273036004788 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 273036004789 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 273036004790 active site 273036004791 KMSKS motif; other site 273036004792 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 273036004793 tRNA binding surface [nucleotide binding]; other site 273036004794 anticodon binding site; other site 273036004795 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 273036004796 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 273036004797 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 273036004798 Putative ammonia monooxygenase; Region: AmoA; pfam05145 273036004799 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 273036004800 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 273036004801 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 273036004802 inhibitor-cofactor binding pocket; inhibition site 273036004803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036004804 catalytic residue [active] 273036004805 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 273036004806 dimer interface [polypeptide binding]; other site 273036004807 active site 273036004808 Schiff base residues; other site 273036004809 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 273036004810 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 273036004811 active site 273036004812 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 273036004813 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 273036004814 domain interfaces; other site 273036004815 active site 273036004816 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 273036004817 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 273036004818 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 273036004819 tRNA; other site 273036004820 putative tRNA binding site [nucleotide binding]; other site 273036004821 putative NADP binding site [chemical binding]; other site 273036004822 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 273036004823 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 273036004824 G1 box; other site 273036004825 GTP/Mg2+ binding site [chemical binding]; other site 273036004826 Switch I region; other site 273036004827 G2 box; other site 273036004828 G3 box; other site 273036004829 Switch II region; other site 273036004830 G4 box; other site 273036004831 G5 box; other site 273036004832 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 273036004833 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 273036004834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036004835 Walker A motif; other site 273036004836 ATP binding site [chemical binding]; other site 273036004837 Walker B motif; other site 273036004838 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 273036004839 trigger factor; Provisional; Region: tig; PRK01490 273036004840 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 273036004841 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 273036004842 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 273036004843 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 273036004844 23S rRNA binding site [nucleotide binding]; other site 273036004845 L21 binding site [polypeptide binding]; other site 273036004846 L13 binding site [polypeptide binding]; other site 273036004847 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 273036004848 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 273036004849 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 273036004850 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 273036004851 lysine transporter; Provisional; Region: PRK10836 273036004852 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 273036004853 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 273036004854 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 273036004855 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 273036004856 active site 273036004857 dimer interface [polypeptide binding]; other site 273036004858 motif 1; other site 273036004859 motif 2; other site 273036004860 motif 3; other site 273036004861 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 273036004862 anticodon binding site; other site 273036004863 primosomal protein DnaI; Reviewed; Region: PRK08939 273036004864 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 273036004865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036004866 Walker A motif; other site 273036004867 ATP binding site [chemical binding]; other site 273036004868 Walker B motif; other site 273036004869 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 273036004870 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 273036004871 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 273036004872 ATP cone domain; Region: ATP-cone; pfam03477 273036004873 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 273036004874 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 273036004875 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 273036004876 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 273036004877 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 273036004878 CoA-binding site [chemical binding]; other site 273036004879 ATP-binding [chemical binding]; other site 273036004880 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 273036004881 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 273036004882 DNA binding site [nucleotide binding] 273036004883 catalytic residue [active] 273036004884 H2TH interface [polypeptide binding]; other site 273036004885 putative catalytic residues [active] 273036004886 turnover-facilitating residue; other site 273036004887 intercalation triad [nucleotide binding]; other site 273036004888 8OG recognition residue [nucleotide binding]; other site 273036004889 putative reading head residues; other site 273036004890 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 273036004891 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 273036004892 DNA polymerase I; Provisional; Region: PRK05755 273036004893 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 273036004894 active site 273036004895 metal binding site 1 [ion binding]; metal-binding site 273036004896 putative 5' ssDNA interaction site; other site 273036004897 metal binding site 3; metal-binding site 273036004898 metal binding site 2 [ion binding]; metal-binding site 273036004899 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 273036004900 putative DNA binding site [nucleotide binding]; other site 273036004901 putative metal binding site [ion binding]; other site 273036004902 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 273036004903 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 273036004904 active site 273036004905 DNA binding site [nucleotide binding] 273036004906 catalytic site [active] 273036004907 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 273036004908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273036004909 dimer interface [polypeptide binding]; other site 273036004910 phosphorylation site [posttranslational modification] 273036004911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036004912 ATP binding site [chemical binding]; other site 273036004913 Mg2+ binding site [ion binding]; other site 273036004914 G-X-G motif; other site 273036004915 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273036004916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273036004917 active site 273036004918 phosphorylation site [posttranslational modification] 273036004919 intermolecular recognition site; other site 273036004920 dimerization interface [polypeptide binding]; other site 273036004921 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273036004922 DNA binding site [nucleotide binding] 273036004923 isocitrate dehydrogenase; Reviewed; Region: PRK07006 273036004924 isocitrate dehydrogenase; Validated; Region: PRK07362 273036004925 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 273036004926 dimer interface [polypeptide binding]; other site 273036004927 Citrate synthase; Region: Citrate_synt; pfam00285 273036004928 active site 273036004929 citrylCoA binding site [chemical binding]; other site 273036004930 oxalacetate/citrate binding site [chemical binding]; other site 273036004931 coenzyme A binding site [chemical binding]; other site 273036004932 catalytic triad [active] 273036004933 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 273036004934 pyruvate kinase; Provisional; Region: PRK06354 273036004935 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 273036004936 domain interfaces; other site 273036004937 active site 273036004938 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 273036004939 6-phosphofructokinase; Provisional; Region: PRK03202 273036004940 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 273036004941 active site 273036004942 ADP/pyrophosphate binding site [chemical binding]; other site 273036004943 dimerization interface [polypeptide binding]; other site 273036004944 allosteric effector site; other site 273036004945 fructose-1,6-bisphosphate binding site; other site 273036004946 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 273036004947 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 273036004948 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 273036004949 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 273036004950 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 273036004951 Malic enzyme, N-terminal domain; Region: malic; pfam00390 273036004952 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 273036004953 putative NAD(P) binding site [chemical binding]; other site 273036004954 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 273036004955 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 273036004956 active site 273036004957 PHP Thumb interface [polypeptide binding]; other site 273036004958 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 273036004959 generic binding surface I; other site 273036004960 generic binding surface II; other site 273036004961 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 273036004962 DHH family; Region: DHH; pfam01368 273036004963 DHHA1 domain; Region: DHHA1; pfam02272 273036004964 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 273036004965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 273036004966 DNA-binding site [nucleotide binding]; DNA binding site 273036004967 DRTGG domain; Region: DRTGG; pfam07085 273036004968 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 273036004969 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 273036004970 active site 2 [active] 273036004971 active site 1 [active] 273036004972 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 273036004973 Ligand Binding Site [chemical binding]; other site 273036004974 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 273036004975 metal-dependent hydrolase; Provisional; Region: PRK00685 273036004976 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 273036004977 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 273036004978 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 273036004979 active site 273036004980 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 273036004981 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 273036004982 hexamer interface [polypeptide binding]; other site 273036004983 ligand binding site [chemical binding]; other site 273036004984 putative active site [active] 273036004985 NAD(P) binding site [chemical binding]; other site 273036004986 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 273036004987 Ligand Binding Site [chemical binding]; other site 273036004988 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 273036004989 propionate/acetate kinase; Provisional; Region: PRK12379 273036004990 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 273036004991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036004992 S-adenosylmethionine binding site [chemical binding]; other site 273036004993 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 273036004994 dimer interface [polypeptide binding]; other site 273036004995 catalytic triad [active] 273036004996 peroxidatic and resolving cysteines [active] 273036004997 hypothetical protein; Provisional; Region: PRK10621 273036004998 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 273036004999 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 273036005000 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 273036005001 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 273036005002 Ligand Binding Site [chemical binding]; other site 273036005003 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 273036005004 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 273036005005 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273036005006 catalytic residue [active] 273036005007 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 273036005008 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 273036005009 GAF domain; Region: GAF_2; pfam13185 273036005010 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 273036005011 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 273036005012 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273036005013 RNA binding surface [nucleotide binding]; other site 273036005014 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 273036005015 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 273036005016 active site 273036005017 catalytic site [active] 273036005018 OsmC-like protein; Region: OsmC; cl00767 273036005019 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 273036005020 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273036005021 catalytic residue [active] 273036005022 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 273036005023 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 273036005024 ligand binding site [chemical binding]; other site 273036005025 NAD binding site [chemical binding]; other site 273036005026 dimerization interface [polypeptide binding]; other site 273036005027 catalytic site [active] 273036005028 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 273036005029 putative L-serine binding site [chemical binding]; other site 273036005030 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 273036005031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036005032 motif II; other site 273036005033 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 273036005034 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 273036005035 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 273036005036 active site turn [active] 273036005037 phosphorylation site [posttranslational modification] 273036005038 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 273036005039 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 273036005040 putative acyl-acceptor binding pocket; other site 273036005041 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 273036005042 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 273036005043 protein binding site [polypeptide binding]; other site 273036005044 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 273036005045 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 273036005046 active site 273036005047 HIGH motif; other site 273036005048 dimer interface [polypeptide binding]; other site 273036005049 KMSKS motif; other site 273036005050 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273036005051 RNA binding surface [nucleotide binding]; other site 273036005052 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 273036005053 Transglycosylase; Region: Transgly; pfam00912 273036005054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 273036005055 Transposase; Region: DDE_Tnp_ISL3; pfam01610 273036005056 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 273036005057 NEAr Transporter domain; Region: NEAT; smart00725 273036005058 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 273036005059 heme-binding site [chemical binding]; other site 273036005060 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 273036005061 NEAr Transporter domain; Region: NEAT; smart00725 273036005062 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 273036005063 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 273036005064 Potassium binding sites [ion binding]; other site 273036005065 Cesium cation binding sites [ion binding]; other site 273036005066 acetyl-CoA synthetase; Provisional; Region: PRK04319 273036005067 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 273036005068 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 273036005069 active site 273036005070 acyl-activating enzyme (AAE) consensus motif; other site 273036005071 putative CoA binding site [chemical binding]; other site 273036005072 AMP binding site [chemical binding]; other site 273036005073 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 273036005074 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 273036005075 active site 273036005076 Zn binding site [ion binding]; other site 273036005077 catabolite control protein A; Region: ccpA; TIGR01481 273036005078 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273036005079 DNA binding site [nucleotide binding] 273036005080 domain linker motif; other site 273036005081 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 273036005082 dimerization interface [polypeptide binding]; other site 273036005083 effector binding site; other site 273036005084 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 273036005085 Chorismate mutase type II; Region: CM_2; cl00693 273036005086 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 273036005087 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 273036005088 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 273036005089 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 273036005090 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273036005091 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 273036005092 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 273036005093 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 273036005094 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 273036005095 putative tRNA-binding site [nucleotide binding]; other site 273036005096 hypothetical protein; Provisional; Region: PRK13668 273036005097 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 273036005098 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 273036005099 catalytic residues [active] 273036005100 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 273036005101 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 273036005102 oligomer interface [polypeptide binding]; other site 273036005103 active site 273036005104 metal binding site [ion binding]; metal-binding site 273036005105 Predicted small secreted protein [Function unknown]; Region: COG5584 273036005106 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 273036005107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036005108 S-adenosylmethionine binding site [chemical binding]; other site 273036005109 Phosphotransferase enzyme family; Region: APH; pfam01636 273036005110 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 273036005111 active site 273036005112 substrate binding site [chemical binding]; other site 273036005113 ATP binding site [chemical binding]; other site 273036005114 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 273036005115 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 273036005116 homodimer interface [polypeptide binding]; other site 273036005117 substrate-cofactor binding pocket; other site 273036005118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036005119 catalytic residue [active] 273036005120 dipeptidase PepV; Reviewed; Region: PRK07318 273036005121 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 273036005122 active site 273036005123 metal binding site [ion binding]; metal-binding site 273036005124 YtxH-like protein; Region: YtxH; cl02079 273036005125 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 273036005126 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273036005127 RNA binding surface [nucleotide binding]; other site 273036005128 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 273036005129 active site 273036005130 uracil binding [chemical binding]; other site 273036005131 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 273036005132 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 273036005133 HI0933-like protein; Region: HI0933_like; pfam03486 273036005134 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 273036005135 surface-anchored fmtB-like protein 273036005136 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 273036005137 active site residue [active] 273036005138 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 273036005139 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 273036005140 HIGH motif; other site 273036005141 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 273036005142 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 273036005143 active site 273036005144 KMSKS motif; other site 273036005145 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 273036005146 tRNA binding surface [nucleotide binding]; other site 273036005147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036005148 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273036005149 putative substrate translocation pore; other site 273036005150 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 273036005151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036005152 S-adenosylmethionine binding site [chemical binding]; other site 273036005153 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 273036005154 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 273036005155 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 273036005156 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 273036005157 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 273036005158 homopentamer interface [polypeptide binding]; other site 273036005159 active site 273036005160 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 273036005161 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 273036005162 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 273036005163 dimerization interface [polypeptide binding]; other site 273036005164 active site 273036005165 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 273036005166 Lumazine binding domain; Region: Lum_binding; pfam00677 273036005167 Lumazine binding domain; Region: Lum_binding; pfam00677 273036005168 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 273036005169 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 273036005170 catalytic motif [active] 273036005171 Zn binding site [ion binding]; other site 273036005172 RibD C-terminal domain; Region: RibD_C; cl17279 273036005173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 273036005174 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 273036005175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 273036005176 dimerization interface [polypeptide binding]; other site 273036005177 putative DNA binding site [nucleotide binding]; other site 273036005178 putative Zn2+ binding site [ion binding]; other site 273036005179 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 273036005180 arsenical pump membrane protein; Provisional; Region: PRK15445 273036005181 transmembrane helices; other site 273036005182 Low molecular weight phosphatase family; Region: LMWPc; cd00115 273036005183 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 273036005184 active site 273036005185 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 273036005186 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 273036005187 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 273036005188 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 273036005189 DNA binding residues [nucleotide binding] 273036005190 probable membrane protein 273036005191 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 273036005192 active site 273036005193 intersubunit interactions; other site 273036005194 catalytic residue [active] 273036005195 camphor resistance protein CrcB; Provisional; Region: PRK14201 273036005196 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 273036005197 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273036005198 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 273036005199 active site 273036005200 catalytic tetrad [active] 273036005201 S-adenosylmethionine synthetase; Validated; Region: PRK05250 273036005202 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 273036005203 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 273036005204 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 273036005205 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 273036005206 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 273036005207 active site 273036005208 substrate-binding site [chemical binding]; other site 273036005209 metal-binding site [ion binding] 273036005210 ATP binding site [chemical binding]; other site 273036005211 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 273036005212 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 273036005213 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 273036005214 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 273036005215 nudix motif; other site 273036005216 Haemolytic domain; Region: Haemolytic; pfam01809 273036005217 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 273036005218 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 273036005219 metal binding site [ion binding]; metal-binding site 273036005220 substrate binding pocket [chemical binding]; other site 273036005221 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 273036005222 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 273036005223 acyl-activating enzyme (AAE) consensus motif; other site 273036005224 putative AMP binding site [chemical binding]; other site 273036005225 putative active site [active] 273036005226 putative CoA binding site [chemical binding]; other site 273036005227 lipoprotein 273036005228 Excalibur calcium-binding domain; Region: Excalibur; smart00894 273036005229 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 273036005230 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 273036005231 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 273036005232 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 273036005233 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 273036005234 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 273036005235 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 273036005236 substrate binding site [chemical binding]; other site 273036005237 catalytic residues [active] 273036005238 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 273036005239 hypothetical protein 273036005240 hypothetical protein 273036005241 probable specificity determinant 273036005242 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 273036005243 HsdM N-terminal domain; Region: HsdM_N; pfam12161 273036005244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036005245 S-adenosylmethionine binding site [chemical binding]; other site 273036005246 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 273036005247 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 273036005248 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 273036005249 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 273036005250 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 273036005251 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 273036005252 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 273036005253 serine proteinase 273036005254 similar to hypothetical protein found in other Staphylococcal genomes; contains a frameshift 273036005255 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 273036005256 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 273036005257 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 273036005258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273036005259 Walker A/P-loop; other site 273036005260 ATP binding site [chemical binding]; other site 273036005261 Q-loop/lid; other site 273036005262 ABC transporter signature motif; other site 273036005263 Walker B; other site 273036005264 D-loop; other site 273036005265 H-loop/switch region; other site 273036005266 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 273036005267 active site 273036005268 catalytic triad [active] 273036005269 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 273036005270 Flavoprotein; Region: Flavoprotein; pfam02441 273036005271 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 273036005272 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 273036005273 active site 273036005274 zinc binding site [ion binding]; other site 273036005275 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 273036005276 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 273036005277 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 273036005278 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 273036005279 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 273036005280 beta-channel forming cytolysin; Region: hlyII; TIGR01002 273036005281 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 273036005282 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 273036005283 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 273036005284 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 273036005285 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 273036005286 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 273036005287 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 273036005288 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036005289 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 273036005290 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036005291 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 273036005292 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036005293 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 273036005294 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036005295 enterotoxin M 273036005296 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 273036005297 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036005298 probable integrated prophage 273036005299 CHAP domain; Region: CHAP; pfam05257 273036005300 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 273036005301 amidase catalytic site [active] 273036005302 Zn binding residues [ion binding]; other site 273036005303 substrate binding site [chemical binding]; other site 273036005304 Bacterial SH3 domain; Region: SH3_5; pfam08460 273036005305 Bacteriophage holin; Region: Phage_holin_1; pfam04531 273036005306 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 273036005307 CHAP domain; Region: CHAP; pfam05257 273036005308 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 273036005309 Lysozyme subfamily 2; Region: LYZ2; smart00047 273036005310 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 273036005311 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 273036005312 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 273036005313 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 273036005314 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 273036005315 active site 273036005316 catalytic triad [active] 273036005317 oxyanion hole [active] 273036005318 Phage tail protein; Region: Sipho_tail; pfam05709 273036005319 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 273036005320 Phage-related protein [Function unknown]; Region: COG5412 273036005321 membrane protein P6; Region: PHA01399 273036005322 Phage protein; Region: DUF3647; pfam12363 273036005323 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 273036005324 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 273036005325 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 273036005326 Phage capsid family; Region: Phage_capsid; pfam05065 273036005327 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 273036005328 phage putative head morphogenesis protein, SPP1 gp7 family; Region: phageSPP1_gp7; TIGR01641 273036005329 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 273036005330 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 273036005331 Phage terminase large subunit; Region: Terminase_3; cl12054 273036005332 Terminase-like family; Region: Terminase_6; pfam03237 273036005333 Terminase small subunit; Region: Terminase_2; pfam03592 273036005334 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 273036005335 Transcriptional activator RinB; Region: RinB; pfam06116 273036005336 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 273036005337 dUTPase; Region: dUTPase_2; pfam08761 273036005338 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 273036005339 active site 273036005340 homodimer interface [polypeptide binding]; other site 273036005341 metal binding site [ion binding]; metal-binding site 273036005342 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 273036005343 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 273036005344 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 273036005345 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 273036005346 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 273036005347 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 273036005348 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 273036005349 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 273036005350 Walker A motif; other site 273036005351 ATP binding site [chemical binding]; other site 273036005352 Walker B motif; other site 273036005353 DNA binding loops [nucleotide binding] 273036005354 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 273036005355 Protein of unknown function (DUF968); Region: DUF968; pfam06147 273036005356 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 273036005357 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 273036005358 dimer interface [polypeptide binding]; other site 273036005359 ssDNA binding site [nucleotide binding]; other site 273036005360 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273036005361 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 273036005362 Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656 273036005363 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 273036005364 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 273036005365 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 273036005366 Domain of unknown function (DUF771); Region: DUF771; cl09962 273036005367 AntA/AntB antirepressor; Region: AntA; cl01430 273036005368 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 273036005369 Prophage antirepressor [Transcription]; Region: COG3617 273036005370 BRO family, N-terminal domain; Region: Bro-N; smart01040 273036005371 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 273036005372 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 273036005373 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273036005374 non-specific DNA binding site [nucleotide binding]; other site 273036005375 salt bridge; other site 273036005376 sequence-specific DNA binding site [nucleotide binding]; other site 273036005377 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 273036005378 Catalytic site [active] 273036005379 integrase; Provisional; Region: int; PHA02601 273036005380 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 273036005381 Int/Topo IB signature motif; other site 273036005382 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 273036005383 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 273036005384 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 273036005385 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 273036005386 ferrochelatase; Provisional; Region: PRK12435 273036005387 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 273036005388 C-terminal domain interface [polypeptide binding]; other site 273036005389 active site 273036005390 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 273036005391 active site 273036005392 N-terminal domain interface [polypeptide binding]; other site 273036005393 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 273036005394 substrate binding site [chemical binding]; other site 273036005395 active site 273036005396 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 273036005397 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 273036005398 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 273036005399 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 273036005400 Walker A/P-loop; other site 273036005401 ATP binding site [chemical binding]; other site 273036005402 Q-loop/lid; other site 273036005403 ABC transporter signature motif; other site 273036005404 Walker B; other site 273036005405 D-loop; other site 273036005406 H-loop/switch region; other site 273036005407 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 273036005408 HIT family signature motif; other site 273036005409 catalytic residue [active] 273036005410 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 273036005411 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 273036005412 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 273036005413 SurA N-terminal domain; Region: SurA_N_3; cl07813 273036005414 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 273036005415 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 273036005416 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 273036005417 generic binding surface II; other site 273036005418 generic binding surface I; other site 273036005419 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273036005420 Zn2+ binding site [ion binding]; other site 273036005421 Mg2+ binding site [ion binding]; other site 273036005422 Uncharacterized conserved protein [Function unknown]; Region: COG4717 273036005423 P-loop containing region of AAA domain; Region: AAA_29; cl17516 273036005424 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 273036005425 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 273036005426 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 273036005427 active site 273036005428 metal binding site [ion binding]; metal-binding site 273036005429 DNA binding site [nucleotide binding] 273036005430 hypothetical protein; Provisional; Region: PRK13676 273036005431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 273036005432 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 273036005433 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273036005434 non-specific DNA binding site [nucleotide binding]; other site 273036005435 salt bridge; other site 273036005436 sequence-specific DNA binding site [nucleotide binding]; other site 273036005437 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 273036005438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273036005439 active site 273036005440 phosphorylation site [posttranslational modification] 273036005441 intermolecular recognition site; other site 273036005442 dimerization interface [polypeptide binding]; other site 273036005443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273036005444 DNA binding residues [nucleotide binding] 273036005445 dimerization interface [polypeptide binding]; other site 273036005446 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 273036005447 GAF domain; Region: GAF_3; pfam13492 273036005448 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 273036005449 Histidine kinase; Region: HisKA_3; pfam07730 273036005450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036005451 ATP binding site [chemical binding]; other site 273036005452 Mg2+ binding site [ion binding]; other site 273036005453 G-X-G motif; other site 273036005454 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 273036005455 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 273036005456 active site 273036005457 fumarate hydratase; Reviewed; Region: fumC; PRK00485 273036005458 Class II fumarases; Region: Fumarase_classII; cd01362 273036005459 active site 273036005460 tetramer interface [polypeptide binding]; other site 273036005461 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 273036005462 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 273036005463 active site 273036005464 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 273036005465 epoxyqueuosine reductase; Region: TIGR00276 273036005466 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 273036005467 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 273036005468 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 273036005469 Walker A/P-loop; other site 273036005470 ATP binding site [chemical binding]; other site 273036005471 Q-loop/lid; other site 273036005472 ABC transporter signature motif; other site 273036005473 Walker B; other site 273036005474 D-loop; other site 273036005475 H-loop/switch region; other site 273036005476 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273036005477 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 273036005478 substrate binding pocket [chemical binding]; other site 273036005479 membrane-bound complex binding site; other site 273036005480 hinge residues; other site 273036005481 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 273036005482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036005483 dimer interface [polypeptide binding]; other site 273036005484 conserved gate region; other site 273036005485 putative PBP binding loops; other site 273036005486 ABC-ATPase subunit interface; other site 273036005487 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 273036005488 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 273036005489 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 273036005490 metal binding site 2 [ion binding]; metal-binding site 273036005491 putative DNA binding helix; other site 273036005492 metal binding site 1 [ion binding]; metal-binding site 273036005493 dimer interface [polypeptide binding]; other site 273036005494 structural Zn2+ binding site [ion binding]; other site 273036005495 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 273036005496 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 273036005497 putative ligand binding site [chemical binding]; other site 273036005498 NAD binding site [chemical binding]; other site 273036005499 catalytic site [active] 273036005500 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 273036005501 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 273036005502 catalytic triad [active] 273036005503 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 273036005504 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 273036005505 inhibitor-cofactor binding pocket; inhibition site 273036005506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036005507 catalytic residue [active] 273036005508 Predicted membrane protein [Function unknown]; Region: COG4129 273036005509 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 273036005510 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273036005511 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273036005512 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 273036005513 Walker A/P-loop; other site 273036005514 ATP binding site [chemical binding]; other site 273036005515 Q-loop/lid; other site 273036005516 ABC transporter signature motif; other site 273036005517 Walker B; other site 273036005518 D-loop; other site 273036005519 H-loop/switch region; other site 273036005520 hypothetical protein; Provisional; Region: PRK13662 273036005521 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 273036005522 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 273036005523 minor groove reading motif; other site 273036005524 helix-hairpin-helix signature motif; other site 273036005525 substrate binding pocket [chemical binding]; other site 273036005526 active site 273036005527 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 273036005528 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 273036005529 DNA binding and oxoG recognition site [nucleotide binding] 273036005530 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 273036005531 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 273036005532 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 273036005533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273036005534 Walker A/P-loop; other site 273036005535 ATP binding site [chemical binding]; other site 273036005536 Q-loop/lid; other site 273036005537 ABC transporter signature motif; other site 273036005538 Walker B; other site 273036005539 H-loop/switch region; other site 273036005540 recombination regulator RecX; Provisional; Region: recX; PRK14135 273036005541 glycosyltransferase; Provisional; Region: PRK13481 273036005542 Transglycosylase; Region: Transgly; pfam00912 273036005543 intracellular protease, PfpI family; Region: PfpI; TIGR01382 273036005544 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 273036005545 proposed catalytic triad [active] 273036005546 conserved cys residue [active] 273036005547 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 273036005548 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273036005549 FeS/SAM binding site; other site 273036005550 YfkB-like domain; Region: YfkB; pfam08756 273036005551 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 273036005552 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 273036005553 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 273036005554 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 273036005555 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 273036005556 Low molecular weight phosphatase family; Region: LMWPc; cd00115 273036005557 active site 273036005558 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 273036005559 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 273036005560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273036005561 active site 273036005562 phosphorylation site [posttranslational modification] 273036005563 intermolecular recognition site; other site 273036005564 dimerization interface [polypeptide binding]; other site 273036005565 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273036005566 DNA binding residues [nucleotide binding] 273036005567 dimerization interface [polypeptide binding]; other site 273036005568 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 273036005569 Histidine kinase; Region: HisKA_3; pfam07730 273036005570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036005571 ATP binding site [chemical binding]; other site 273036005572 Mg2+ binding site [ion binding]; other site 273036005573 G-X-G motif; other site 273036005574 Predicted membrane protein [Function unknown]; Region: COG4758 273036005575 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 273036005576 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 273036005577 active site 273036005578 Predicted membrane protein [Function unknown]; Region: COG4129 273036005579 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 273036005580 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 273036005581 catalytic triad [active] 273036005582 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 273036005583 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 273036005584 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 273036005585 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 273036005586 Ferritin-like domain; Region: Ferritin; pfam00210 273036005587 ferroxidase diiron center [ion binding]; other site 273036005588 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 273036005589 active site 273036005590 catalytic site [active] 273036005591 substrate binding site [chemical binding]; other site 273036005592 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 273036005593 active site 273036005594 DNA polymerase IV; Validated; Region: PRK02406 273036005595 DNA binding site [nucleotide binding] 273036005596 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 273036005597 TRAM domain; Region: TRAM; cl01282 273036005598 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 273036005599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036005600 S-adenosylmethionine binding site [chemical binding]; other site 273036005601 putative lipid kinase; Reviewed; Region: PRK13337 273036005602 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 273036005603 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 273036005604 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 273036005605 GatB domain; Region: GatB_Yqey; pfam02637 273036005606 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 273036005607 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 273036005608 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 273036005609 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 273036005610 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 273036005611 Na binding site [ion binding]; other site 273036005612 Predicted transcriptional regulators [Transcription]; Region: COG1733 273036005613 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 273036005614 dimerization interface [polypeptide binding]; other site 273036005615 putative Zn2+ binding site [ion binding]; other site 273036005616 putative DNA binding site [nucleotide binding]; other site 273036005617 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 273036005618 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 273036005619 FMN binding site [chemical binding]; other site 273036005620 substrate binding site [chemical binding]; other site 273036005621 putative catalytic residue [active] 273036005622 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 273036005623 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 273036005624 putative dimer interface [polypeptide binding]; other site 273036005625 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 273036005626 putative dimer interface [polypeptide binding]; other site 273036005627 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 273036005628 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 273036005629 nucleotide binding pocket [chemical binding]; other site 273036005630 K-X-D-G motif; other site 273036005631 catalytic site [active] 273036005632 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 273036005633 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 273036005634 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 273036005635 Dimer interface [polypeptide binding]; other site 273036005636 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 273036005637 Part of AAA domain; Region: AAA_19; pfam13245 273036005638 Family description; Region: UvrD_C_2; pfam13538 273036005639 PcrB family; Region: PcrB; pfam01884 273036005640 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 273036005641 substrate binding site [chemical binding]; other site 273036005642 putative active site [active] 273036005643 dimer interface [polypeptide binding]; other site 273036005644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 273036005645 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 273036005646 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 273036005647 tetramer interface [polypeptide binding]; other site 273036005648 active site 273036005649 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 273036005650 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 273036005651 Staphostatin A; Region: Staphostatin_A; pfam09022 273036005652 NETI protein; Region: NETI; pfam14044 273036005653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 273036005654 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 273036005655 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 273036005656 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 273036005657 homodimer interface [polypeptide binding]; other site 273036005658 NAD binding pocket [chemical binding]; other site 273036005659 ATP binding pocket [chemical binding]; other site 273036005660 Mg binding site [ion binding]; other site 273036005661 active-site loop [active] 273036005662 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 273036005663 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 273036005664 active site 273036005665 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 273036005666 active site 273036005667 dimer interface [polypeptide binding]; other site 273036005668 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 273036005669 Prephenate dehydratase; Region: PDT; pfam00800 273036005670 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 273036005671 putative L-Phe binding site [chemical binding]; other site 273036005672 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 273036005673 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 273036005674 transmembrane helices; other site 273036005675 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 273036005676 Isochorismatase family; Region: Isochorismatase; pfam00857 273036005677 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 273036005678 catalytic triad [active] 273036005679 conserved cis-peptide bond; other site 273036005680 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 273036005681 DHH family; Region: DHH; pfam01368 273036005682 DHHA2 domain; Region: DHHA2; pfam02833 273036005683 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 273036005684 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 273036005685 NAD(P) binding site [chemical binding]; other site 273036005686 catalytic residues [active] 273036005687 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 273036005688 YolD-like protein; Region: YolD; pfam08863 273036005689 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 273036005690 active site 273036005691 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 273036005692 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 273036005693 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 273036005694 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 273036005695 Bacterial PH domain; Region: DUF304; cl01348 273036005696 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 273036005697 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 273036005698 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 273036005699 Walker A/P-loop; other site 273036005700 ATP binding site [chemical binding]; other site 273036005701 Q-loop/lid; other site 273036005702 ABC transporter signature motif; other site 273036005703 Walker B; other site 273036005704 D-loop; other site 273036005705 H-loop/switch region; other site 273036005706 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 273036005707 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 273036005708 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 273036005709 Walker A/P-loop; other site 273036005710 ATP binding site [chemical binding]; other site 273036005711 Q-loop/lid; other site 273036005712 ABC transporter signature motif; other site 273036005713 Walker B; other site 273036005714 D-loop; other site 273036005715 H-loop/switch region; other site 273036005716 Predicted transcriptional regulators [Transcription]; Region: COG1725 273036005717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273036005718 DNA-binding site [nucleotide binding]; DNA binding site 273036005719 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 273036005720 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273036005721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036005722 homodimer interface [polypeptide binding]; other site 273036005723 catalytic residue [active] 273036005724 MAP domain; Region: MAP; pfam03642 273036005725 MAP domain; Region: MAP; pfam03642 273036005726 MAP domain; Region: MAP; pfam03642 273036005727 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 273036005728 putative catalytic site [active] 273036005729 metal binding site A [ion binding]; metal-binding site 273036005730 phosphate binding site [ion binding]; other site 273036005731 metal binding site C [ion binding]; metal-binding site 273036005732 metal binding site B [ion binding]; metal-binding site 273036005733 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 273036005734 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 273036005735 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 273036005736 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 273036005737 metal binding site [ion binding]; metal-binding site 273036005738 dimer interface [polypeptide binding]; other site 273036005739 EamA-like transporter family; Region: EamA; cl17759 273036005740 EamA-like transporter family; Region: EamA; pfam00892 273036005741 5-aminolevulinate synthase; Validated; Region: PRK09064 273036005742 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 273036005743 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273036005744 catalytic residue [active] 273036005745 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 273036005746 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 273036005747 probable pathogenicity island SaPIbovBeta, partial duplication of SaPIbov 273036005748 genomic island imperfect repeat SaPIbovBetaL 273036005749 hypothetical protein 273036005750 hypothetical protein 273036005751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 273036005752 mobile element-associated protein 273036005753 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 273036005754 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 273036005755 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 273036005756 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 273036005757 DNA binding domain, excisionase family; Region: excise; TIGR01764 273036005758 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 273036005759 sequence-specific DNA binding site [nucleotide binding]; other site 273036005760 salt bridge; other site 273036005761 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 273036005762 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273036005763 non-specific DNA binding site [nucleotide binding]; other site 273036005764 salt bridge; other site 273036005765 sequence-specific DNA binding site [nucleotide binding]; other site 273036005766 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 273036005767 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 273036005768 Int/Topo IB signature motif; other site 273036005769 genomic island imperfect repeat SaPIbovBetaR 273036005770 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 273036005771 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 273036005772 ring oligomerisation interface [polypeptide binding]; other site 273036005773 ATP/Mg binding site [chemical binding]; other site 273036005774 stacking interactions; other site 273036005775 hinge regions; other site 273036005776 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 273036005777 oligomerisation interface [polypeptide binding]; other site 273036005778 mobile loop; other site 273036005779 roof hairpin; other site 273036005780 CAAX protease self-immunity; Region: Abi; pfam02517 273036005781 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 273036005782 dimer interface [polypeptide binding]; other site 273036005783 FMN binding site [chemical binding]; other site 273036005784 Predicted amidohydrolase [General function prediction only]; Region: COG0388 273036005785 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 273036005786 putative active site [active] 273036005787 catalytic triad [active] 273036005788 putative dimer interface [polypeptide binding]; other site 273036005789 Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription]; Region: AgrB; COG4512 273036005790 Staphylococcal AgrD protein; Region: AgrD; pfam05931 273036005791 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 273036005792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036005793 Mg2+ binding site [ion binding]; other site 273036005794 G-X-G motif; other site 273036005795 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 273036005796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273036005797 active site 273036005798 phosphorylation site [posttranslational modification] 273036005799 intermolecular recognition site; other site 273036005800 dimerization interface [polypeptide binding]; other site 273036005801 LytTr DNA-binding domain; Region: LytTR; pfam04397 273036005802 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 273036005803 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 273036005804 putative substrate binding site [chemical binding]; other site 273036005805 putative ATP binding site [chemical binding]; other site 273036005806 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 273036005807 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 273036005808 substrate binding [chemical binding]; other site 273036005809 active site 273036005810 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 273036005811 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273036005812 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273036005813 DNA binding site [nucleotide binding] 273036005814 domain linker motif; other site 273036005815 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 273036005816 dimerization interface [polypeptide binding]; other site 273036005817 ligand binding site [chemical binding]; other site 273036005818 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 273036005819 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 273036005820 CPxP motif; other site 273036005821 Predicted transporter component [General function prediction only]; Region: COG2391 273036005822 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 273036005823 Sulphur transport; Region: Sulf_transp; pfam04143 273036005824 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 273036005825 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 273036005826 CoA binding domain; Region: CoA_binding; pfam02629 273036005827 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 273036005828 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273036005829 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273036005830 ABC transporter; Region: ABC_tran_2; pfam12848 273036005831 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273036005832 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 273036005833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273036005834 Walker A/P-loop; other site 273036005835 ATP binding site [chemical binding]; other site 273036005836 Q-loop/lid; other site 273036005837 ABC transporter signature motif; other site 273036005838 Walker B; other site 273036005839 D-loop; other site 273036005840 H-loop/switch region; other site 273036005841 UGMP family protein; Validated; Region: PRK09604 273036005842 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 273036005843 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 273036005844 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036005845 Coenzyme A binding pocket [chemical binding]; other site 273036005846 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 273036005847 Glycoprotease family; Region: Peptidase_M22; pfam00814 273036005848 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 273036005849 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 273036005850 6-phosphogluconate dehydratase; Region: edd; TIGR01196 273036005851 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 273036005852 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 273036005853 PYR/PP interface [polypeptide binding]; other site 273036005854 dimer interface [polypeptide binding]; other site 273036005855 TPP binding site [chemical binding]; other site 273036005856 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 273036005857 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 273036005858 TPP-binding site [chemical binding]; other site 273036005859 dimer interface [polypeptide binding]; other site 273036005860 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 273036005861 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 273036005862 ketol-acid reductoisomerase; Provisional; Region: PRK05479 273036005863 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 273036005864 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 273036005865 2-isopropylmalate synthase; Validated; Region: PRK00915 273036005866 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 273036005867 active site 273036005868 catalytic residues [active] 273036005869 metal binding site [ion binding]; metal-binding site 273036005870 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 273036005871 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 273036005872 tartrate dehydrogenase; Region: TTC; TIGR02089 273036005873 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 273036005874 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 273036005875 substrate binding site [chemical binding]; other site 273036005876 ligand binding site [chemical binding]; other site 273036005877 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 273036005878 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 273036005879 substrate binding site [chemical binding]; other site 273036005880 threonine dehydratase; Validated; Region: PRK08639 273036005881 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 273036005882 tetramer interface [polypeptide binding]; other site 273036005883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036005884 catalytic residue [active] 273036005885 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 273036005886 putative Ile/Val binding site [chemical binding]; other site 273036005887 hypothetical protein; Provisional; Region: PRK04351 273036005888 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 273036005889 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 273036005890 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 273036005891 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 273036005892 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 273036005893 RNA binding site [nucleotide binding]; other site 273036005894 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 273036005895 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273036005896 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 273036005897 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273036005898 DNA binding residues [nucleotide binding] 273036005899 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 273036005900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036005901 ATP binding site [chemical binding]; other site 273036005902 Mg2+ binding site [ion binding]; other site 273036005903 G-X-G motif; other site 273036005904 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 273036005905 anti sigma factor interaction site; other site 273036005906 regulatory phosphorylation site [posttranslational modification]; other site 273036005907 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 273036005908 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 273036005909 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 273036005910 PemK-like protein; Region: PemK; pfam02452 273036005911 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 273036005912 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 273036005913 active site 273036005914 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273036005915 dimer interface [polypeptide binding]; other site 273036005916 substrate binding site [chemical binding]; other site 273036005917 catalytic residues [active] 273036005918 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 273036005919 Uncharacterized conserved protein [Function unknown]; Region: COG3402 273036005920 Predicted membrane protein [Function unknown]; Region: COG3428 273036005921 Bacterial PH domain; Region: DUF304; pfam03703 273036005922 Bacterial PH domain; Region: DUF304; pfam03703 273036005923 Bacterial PH domain; Region: DUF304; cl01348 273036005924 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 273036005925 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 273036005926 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 273036005927 Soluble P-type ATPase [General function prediction only]; Region: COG4087 273036005928 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 273036005929 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 273036005930 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 273036005931 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 273036005932 Ligand Binding Site [chemical binding]; other site 273036005933 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273036005934 dimer interface [polypeptide binding]; other site 273036005935 phosphorylation site [posttranslational modification] 273036005936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036005937 ATP binding site [chemical binding]; other site 273036005938 Mg2+ binding site [ion binding]; other site 273036005939 G-X-G motif; other site 273036005940 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273036005941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273036005942 active site 273036005943 phosphorylation site [posttranslational modification] 273036005944 intermolecular recognition site; other site 273036005945 dimerization interface [polypeptide binding]; other site 273036005946 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273036005947 DNA binding site [nucleotide binding] 273036005948 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 273036005949 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 273036005950 ATP binding site [chemical binding]; other site 273036005951 Mg++ binding site [ion binding]; other site 273036005952 motif III; other site 273036005953 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273036005954 nucleotide binding region [chemical binding]; other site 273036005955 ATP-binding site [chemical binding]; other site 273036005956 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 273036005957 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 273036005958 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 273036005959 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273036005960 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 273036005961 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 273036005962 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 273036005963 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 273036005964 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 273036005965 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 273036005966 putative homodimer interface [polypeptide binding]; other site 273036005967 putative homotetramer interface [polypeptide binding]; other site 273036005968 allosteric switch controlling residues; other site 273036005969 putative metal binding site [ion binding]; other site 273036005970 putative homodimer-homodimer interface [polypeptide binding]; other site 273036005971 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 273036005972 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 273036005973 putative active site [active] 273036005974 catalytic site [active] 273036005975 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 273036005976 putative active site [active] 273036005977 catalytic site [active] 273036005978 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 273036005979 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273036005980 Zn2+ binding site [ion binding]; other site 273036005981 Mg2+ binding site [ion binding]; other site 273036005982 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 273036005983 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 273036005984 thiamine phosphate binding site [chemical binding]; other site 273036005985 active site 273036005986 pyrophosphate binding site [ion binding]; other site 273036005987 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 273036005988 substrate binding site [chemical binding]; other site 273036005989 multimerization interface [polypeptide binding]; other site 273036005990 ATP binding site [chemical binding]; other site 273036005991 phosphomethylpyrimidine kinase 273036005992 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 273036005993 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 273036005994 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 273036005995 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 273036005996 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 273036005997 dimer interface [polypeptide binding]; other site 273036005998 ssDNA binding site [nucleotide binding]; other site 273036005999 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273036006000 YwpF-like protein; Region: YwpF; pfam14183 273036006001 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 273036006002 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 273036006003 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 273036006004 hinge; other site 273036006005 active site 273036006006 Predicted membrane protein [Function unknown]; Region: COG4836 273036006007 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 273036006008 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 273036006009 gamma subunit interface [polypeptide binding]; other site 273036006010 epsilon subunit interface [polypeptide binding]; other site 273036006011 LBP interface [polypeptide binding]; other site 273036006012 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 273036006013 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 273036006014 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 273036006015 alpha subunit interaction interface [polypeptide binding]; other site 273036006016 Walker A motif; other site 273036006017 ATP binding site [chemical binding]; other site 273036006018 Walker B motif; other site 273036006019 inhibitor binding site; inhibition site 273036006020 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 273036006021 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 273036006022 core domain interface [polypeptide binding]; other site 273036006023 delta subunit interface [polypeptide binding]; other site 273036006024 epsilon subunit interface [polypeptide binding]; other site 273036006025 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 273036006026 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 273036006027 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 273036006028 beta subunit interaction interface [polypeptide binding]; other site 273036006029 Walker A motif; other site 273036006030 ATP binding site [chemical binding]; other site 273036006031 Walker B motif; other site 273036006032 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 273036006033 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 273036006034 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 273036006035 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 273036006036 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 273036006037 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 273036006038 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 273036006039 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 273036006040 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 273036006041 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 273036006042 active site 273036006043 homodimer interface [polypeptide binding]; other site 273036006044 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273036006045 active site 273036006046 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 273036006047 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 273036006048 dimer interface [polypeptide binding]; other site 273036006049 active site 273036006050 glycine-pyridoxal phosphate binding site [chemical binding]; other site 273036006051 folate binding site [chemical binding]; other site 273036006052 hypothetical protein; Provisional; Region: PRK13690 273036006053 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 273036006054 Low molecular weight phosphatase family; Region: LMWPc; cd00115 273036006055 active site 273036006056 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 273036006057 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 273036006058 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 273036006059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036006060 S-adenosylmethionine binding site [chemical binding]; other site 273036006061 peptide chain release factor 1; Validated; Region: prfA; PRK00591 273036006062 This domain is found in peptide chain release factors; Region: PCRF; smart00937 273036006063 RF-1 domain; Region: RF-1; pfam00472 273036006064 thymidine kinase; Provisional; Region: PRK04296 273036006065 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 273036006066 transcription termination factor Rho; Provisional; Region: rho; PRK09376 273036006067 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 273036006068 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 273036006069 RNA binding site [nucleotide binding]; other site 273036006070 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 273036006071 multimer interface [polypeptide binding]; other site 273036006072 Walker A motif; other site 273036006073 ATP binding site [chemical binding]; other site 273036006074 Walker B motif; other site 273036006075 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 273036006076 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 273036006077 NAD binding site [chemical binding]; other site 273036006078 catalytic residues [active] 273036006079 Predicted transcriptional regulators [Transcription]; Region: COG1733 273036006080 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 273036006081 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 273036006082 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 273036006083 hinge; other site 273036006084 active site 273036006085 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 273036006086 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 273036006087 intersubunit interface [polypeptide binding]; other site 273036006088 active site 273036006089 zinc binding site [ion binding]; other site 273036006090 Na+ binding site [ion binding]; other site 273036006091 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 273036006092 CTP synthetase; Validated; Region: pyrG; PRK05380 273036006093 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 273036006094 Catalytic site [active] 273036006095 active site 273036006096 UTP binding site [chemical binding]; other site 273036006097 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 273036006098 active site 273036006099 putative oxyanion hole; other site 273036006100 catalytic triad [active] 273036006101 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 273036006102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036006103 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 273036006104 Coenzyme A binding pocket [chemical binding]; other site 273036006105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 273036006106 pantothenate kinase; Provisional; Region: PRK13317 273036006107 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 273036006108 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 273036006109 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 273036006110 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 273036006111 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 273036006112 metal binding site [ion binding]; metal-binding site 273036006113 S-ribosylhomocysteinase; Provisional; Region: PRK02260 273036006114 Predicted membrane protein [Function unknown]; Region: COG4270 273036006115 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 273036006116 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 273036006117 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 273036006118 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 273036006119 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 273036006120 intersubunit interface [polypeptide binding]; other site 273036006121 active site 273036006122 catalytic residue [active] 273036006123 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 273036006124 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 273036006125 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 273036006126 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 273036006127 dimerization interface [polypeptide binding]; other site 273036006128 DPS ferroxidase diiron center [ion binding]; other site 273036006129 ion pore; other site 273036006130 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 273036006131 EVE domain; Region: EVE; cl00728 273036006132 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 273036006133 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 273036006134 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 273036006135 NADH(P)-binding; Region: NAD_binding_10; pfam13460 273036006136 NAD(P) binding site [chemical binding]; other site 273036006137 putative active site [active] 273036006138 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 273036006139 dimerization interface [polypeptide binding]; other site 273036006140 putative DNA binding site [nucleotide binding]; other site 273036006141 putative Zn2+ binding site [ion binding]; other site 273036006142 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 273036006143 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 273036006144 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 273036006145 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036006146 active site 273036006147 motif I; other site 273036006148 motif II; other site 273036006149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036006150 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 273036006151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273036006152 Walker A/P-loop; other site 273036006153 ATP binding site [chemical binding]; other site 273036006154 Q-loop/lid; other site 273036006155 ABC transporter signature motif; other site 273036006156 Walker B; other site 273036006157 D-loop; other site 273036006158 H-loop/switch region; other site 273036006159 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 273036006160 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 273036006161 glutaminase active site [active] 273036006162 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 273036006163 dimer interface [polypeptide binding]; other site 273036006164 active site 273036006165 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 273036006166 dimer interface [polypeptide binding]; other site 273036006167 active site 273036006168 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 273036006169 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 273036006170 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 273036006171 active site 273036006172 P-loop; other site 273036006173 phosphorylation site [posttranslational modification] 273036006174 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 273036006175 HTH domain; Region: HTH_11; pfam08279 273036006176 Mga helix-turn-helix domain; Region: Mga; pfam05043 273036006177 PRD domain; Region: PRD; pfam00874 273036006178 PRD domain; Region: PRD; pfam00874 273036006179 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 273036006180 active site 273036006181 P-loop; other site 273036006182 phosphorylation site [posttranslational modification] 273036006183 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 273036006184 active site 273036006185 phosphorylation site [posttranslational modification] 273036006186 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273036006187 active site 273036006188 phosphorylation site [posttranslational modification] 273036006189 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 273036006190 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 273036006191 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 273036006192 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 273036006193 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 273036006194 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 273036006195 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 273036006196 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 273036006197 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 273036006198 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 273036006199 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 273036006200 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 273036006201 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 273036006202 active site 273036006203 substrate binding site [chemical binding]; other site 273036006204 metal binding site [ion binding]; metal-binding site 273036006205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 273036006206 YbbR-like protein; Region: YbbR; pfam07949 273036006207 YbbR-like protein; Region: YbbR; pfam07949 273036006208 TIGR00159 family protein; Region: TIGR00159 273036006209 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 273036006210 Arginase family; Region: Arginase; cd09989 273036006211 active site 273036006212 Mn binding site [ion binding]; other site 273036006213 oligomer interface [polypeptide binding]; other site 273036006214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 273036006215 Transposase; Region: DDE_Tnp_ISL3; pfam01610 273036006216 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 273036006217 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 273036006218 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 273036006219 Walker A motif; other site 273036006220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006221 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 273036006222 putative substrate translocation pore; other site 273036006223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006224 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273036006225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006226 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 273036006227 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 273036006228 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 273036006229 substrate binding site; other site 273036006230 dimerization interface; other site 273036006231 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 273036006232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 273036006233 Nucleoside recognition; Region: Gate; pfam07670 273036006234 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 273036006235 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273036006236 ABC-ATPase subunit interface; other site 273036006237 dimer interface [polypeptide binding]; other site 273036006238 putative PBP binding regions; other site 273036006239 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 273036006240 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273036006241 ABC-ATPase subunit interface; other site 273036006242 dimer interface [polypeptide binding]; other site 273036006243 putative PBP binding regions; other site 273036006244 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 273036006245 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 273036006246 siderophore binding site; other site 273036006247 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 273036006248 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 273036006249 dimer interface [polypeptide binding]; other site 273036006250 active site 273036006251 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273036006252 substrate binding site [chemical binding]; other site 273036006253 catalytic residue [active] 273036006254 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 273036006255 IucA / IucC family; Region: IucA_IucC; pfam04183 273036006256 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 273036006257 H+ Antiporter protein; Region: 2A0121; TIGR00900 273036006258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006259 putative substrate translocation pore; other site 273036006260 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 273036006261 IucA / IucC family; Region: IucA_IucC; pfam04183 273036006262 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 273036006263 Asp23 family; Region: Asp23; pfam03780 273036006264 Small integral membrane protein [Function unknown]; Region: COG5547 273036006265 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 273036006266 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 273036006267 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 273036006268 putative NAD(P) binding site [chemical binding]; other site 273036006269 dimer interface [polypeptide binding]; other site 273036006270 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 273036006271 Prostaglandin dehydrogenases; Region: PGDH; cd05288 273036006272 NAD(P) binding site [chemical binding]; other site 273036006273 substrate binding site [chemical binding]; other site 273036006274 dimer interface [polypeptide binding]; other site 273036006275 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 273036006276 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 273036006277 beta-galactosidase; Region: BGL; TIGR03356 273036006278 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 273036006279 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 273036006280 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 273036006281 active site 273036006282 P-loop; other site 273036006283 phosphorylation site [posttranslational modification] 273036006284 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 273036006285 methionine cluster; other site 273036006286 active site 273036006287 phosphorylation site [posttranslational modification] 273036006288 metal binding site [ion binding]; metal-binding site 273036006289 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 273036006290 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 273036006291 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 273036006292 putative substrate binding site [chemical binding]; other site 273036006293 putative ATP binding site [chemical binding]; other site 273036006294 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 273036006295 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 273036006296 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 273036006297 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 273036006298 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 273036006299 NAD-dependent deacetylase; Provisional; Region: PRK00481 273036006300 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 273036006301 NAD+ binding site [chemical binding]; other site 273036006302 substrate binding site [chemical binding]; other site 273036006303 putative Zn binding site [ion binding]; other site 273036006304 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273036006305 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 273036006306 active site 273036006307 catalytic tetrad [active] 273036006308 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 273036006309 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 273036006310 DNA binding residues [nucleotide binding] 273036006311 putative dimer interface [polypeptide binding]; other site 273036006312 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 273036006313 substrate binding site [chemical binding]; other site 273036006314 catalytic residues [active] 273036006315 Predicted transcriptional regulator [Transcription]; Region: COG2378 273036006316 HTH domain; Region: HTH_11; pfam08279 273036006317 WYL domain; Region: WYL; pfam13280 273036006318 intracellular protease, PfpI family; Region: PfpI; TIGR01382 273036006319 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 273036006320 conserved cys residue [active] 273036006321 MAP domain; Region: MAP; pfam03642 273036006322 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 273036006323 acetolactate synthase; Reviewed; Region: PRK08617 273036006324 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 273036006325 PYR/PP interface [polypeptide binding]; other site 273036006326 dimer interface [polypeptide binding]; other site 273036006327 TPP binding site [chemical binding]; other site 273036006328 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 273036006329 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 273036006330 TPP-binding site [chemical binding]; other site 273036006331 dimer interface [polypeptide binding]; other site 273036006332 Transcriptional regulator; Region: Rrf2; cl17282 273036006333 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 273036006334 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 273036006335 23S rRNA interface [nucleotide binding]; other site 273036006336 L3 interface [polypeptide binding]; other site 273036006337 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 273036006338 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 273036006339 dimerization interface 3.5A [polypeptide binding]; other site 273036006340 active site 273036006341 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 273036006342 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 273036006343 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 273036006344 Walker A/P-loop; other site 273036006345 ATP binding site [chemical binding]; other site 273036006346 Q-loop/lid; other site 273036006347 ABC transporter signature motif; other site 273036006348 Walker B; other site 273036006349 D-loop; other site 273036006350 H-loop/switch region; other site 273036006351 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 273036006352 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 273036006353 Walker A/P-loop; other site 273036006354 ATP binding site [chemical binding]; other site 273036006355 Q-loop/lid; other site 273036006356 ABC transporter signature motif; other site 273036006357 Walker B; other site 273036006358 D-loop; other site 273036006359 H-loop/switch region; other site 273036006360 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 273036006361 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 273036006362 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 273036006363 alphaNTD homodimer interface [polypeptide binding]; other site 273036006364 alphaNTD - beta interaction site [polypeptide binding]; other site 273036006365 alphaNTD - beta' interaction site [polypeptide binding]; other site 273036006366 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 273036006367 30S ribosomal protein S11; Validated; Region: PRK05309 273036006368 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 273036006369 30S ribosomal protein S13; Region: bact_S13; TIGR03631 273036006370 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 273036006371 rRNA binding site [nucleotide binding]; other site 273036006372 predicted 30S ribosome binding site; other site 273036006373 adenylate kinase; Reviewed; Region: adk; PRK00279 273036006374 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 273036006375 AMP-binding site [chemical binding]; other site 273036006376 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 273036006377 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 273036006378 SecY translocase; Region: SecY; pfam00344 273036006379 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 273036006380 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 273036006381 23S rRNA binding site [nucleotide binding]; other site 273036006382 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 273036006383 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 273036006384 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 273036006385 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 273036006386 5S rRNA interface [nucleotide binding]; other site 273036006387 L27 interface [polypeptide binding]; other site 273036006388 23S rRNA interface [nucleotide binding]; other site 273036006389 L5 interface [polypeptide binding]; other site 273036006390 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 273036006391 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 273036006392 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 273036006393 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 273036006394 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 273036006395 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 273036006396 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 273036006397 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 273036006398 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 273036006399 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 273036006400 RNA binding site [nucleotide binding]; other site 273036006401 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 273036006402 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 273036006403 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 273036006404 23S rRNA interface [nucleotide binding]; other site 273036006405 putative translocon interaction site; other site 273036006406 signal recognition particle (SRP54) interaction site; other site 273036006407 L23 interface [polypeptide binding]; other site 273036006408 trigger factor interaction site; other site 273036006409 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 273036006410 23S rRNA interface [nucleotide binding]; other site 273036006411 5S rRNA interface [nucleotide binding]; other site 273036006412 putative antibiotic binding site [chemical binding]; other site 273036006413 L25 interface [polypeptide binding]; other site 273036006414 L27 interface [polypeptide binding]; other site 273036006415 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 273036006416 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 273036006417 G-X-X-G motif; other site 273036006418 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 273036006419 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 273036006420 putative translocon binding site; other site 273036006421 protein-rRNA interface [nucleotide binding]; other site 273036006422 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 273036006423 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 273036006424 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 273036006425 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 273036006426 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 273036006427 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 273036006428 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 273036006429 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 273036006430 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 273036006431 probable DNA topoisomerase III 273036006432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036006433 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 273036006434 Coenzyme A binding pocket [chemical binding]; other site 273036006435 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 273036006436 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 273036006437 Predicted permeases [General function prediction only]; Region: COG0679 273036006438 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 273036006439 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 273036006440 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 273036006441 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 273036006442 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 273036006443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006444 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273036006445 putative substrate translocation pore; other site 273036006446 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 273036006447 Transcriptional regulators [Transcription]; Region: MarR; COG1846 273036006448 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 273036006449 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273036006450 FeS/SAM binding site; other site 273036006451 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 273036006452 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 273036006453 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 273036006454 GTP binding site; other site 273036006455 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 273036006456 MoaE interaction surface [polypeptide binding]; other site 273036006457 MoeB interaction surface [polypeptide binding]; other site 273036006458 thiocarboxylated glycine; other site 273036006459 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 273036006460 MoaE homodimer interface [polypeptide binding]; other site 273036006461 MoaD interaction [polypeptide binding]; other site 273036006462 active site residues [active] 273036006463 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 273036006464 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 273036006465 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 273036006466 dimer interface [polypeptide binding]; other site 273036006467 putative functional site; other site 273036006468 putative MPT binding site; other site 273036006469 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 273036006470 trimer interface [polypeptide binding]; other site 273036006471 dimer interface [polypeptide binding]; other site 273036006472 putative active site [active] 273036006473 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 273036006474 MPT binding site; other site 273036006475 trimer interface [polypeptide binding]; other site 273036006476 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 273036006477 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 273036006478 ATP binding site [chemical binding]; other site 273036006479 substrate interface [chemical binding]; other site 273036006480 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273036006481 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 273036006482 Walker A/P-loop; other site 273036006483 ATP binding site [chemical binding]; other site 273036006484 Q-loop/lid; other site 273036006485 ABC transporter signature motif; other site 273036006486 Walker B; other site 273036006487 D-loop; other site 273036006488 H-loop/switch region; other site 273036006489 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 273036006490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036006491 dimer interface [polypeptide binding]; other site 273036006492 conserved gate region; other site 273036006493 putative PBP binding loops; other site 273036006494 ABC-ATPase subunit interface; other site 273036006495 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 273036006496 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273036006497 substrate binding pocket [chemical binding]; other site 273036006498 membrane-bound complex binding site; other site 273036006499 hinge residues; other site 273036006500 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 273036006501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036006502 Coenzyme A binding pocket [chemical binding]; other site 273036006503 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 273036006504 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 273036006505 active site 273036006506 dimerization interface [polypeptide binding]; other site 273036006507 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 273036006508 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 273036006509 intersubunit interface [polypeptide binding]; other site 273036006510 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 273036006511 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 273036006512 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 273036006513 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 273036006514 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 273036006515 alpha-gamma subunit interface [polypeptide binding]; other site 273036006516 beta-gamma subunit interface [polypeptide binding]; other site 273036006517 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 273036006518 gamma-beta subunit interface [polypeptide binding]; other site 273036006519 alpha-beta subunit interface [polypeptide binding]; other site 273036006520 urease subunit alpha; Reviewed; Region: ureC; PRK13207 273036006521 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 273036006522 subunit interactions [polypeptide binding]; other site 273036006523 active site 273036006524 flap region; other site 273036006525 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 273036006526 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 273036006527 dimer interface [polypeptide binding]; other site 273036006528 catalytic residues [active] 273036006529 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 273036006530 UreF; Region: UreF; pfam01730 273036006531 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 273036006532 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 273036006533 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 273036006534 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 273036006535 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 273036006536 Transcriptional regulators [Transcription]; Region: MarR; COG1846 273036006537 Helix-turn-helix domain; Region: HTH_18; pfam12833 273036006538 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273036006539 Surface antigen [General function prediction only]; Region: COG3942 273036006540 CHAP domain; Region: CHAP; pfam05257 273036006541 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 273036006542 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 273036006543 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 273036006544 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 273036006545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 273036006546 Surface antigen [General function prediction only]; Region: COG3942 273036006547 CHAP domain; Region: CHAP; pfam05257 273036006548 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 273036006549 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 273036006550 putative ligand binding site [chemical binding]; other site 273036006551 putative NAD binding site [chemical binding]; other site 273036006552 catalytic site [active] 273036006553 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 273036006554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 273036006555 Transposase; Region: DDE_Tnp_ISL3; pfam01610 273036006556 hypothetical protein; Provisional; Region: PRK06753 273036006557 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 273036006558 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 273036006559 Lysozyme subfamily 2; Region: LYZ2; smart00047 273036006560 Uncharacterized conserved protein [Function unknown]; Region: COG2427 273036006561 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 273036006562 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 273036006563 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 273036006564 4Fe-4S binding domain; Region: Fer4; pfam00037 273036006565 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 273036006566 [4Fe-4S] binding site [ion binding]; other site 273036006567 molybdopterin cofactor binding site; other site 273036006568 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 273036006569 molybdopterin cofactor binding site; other site 273036006570 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 273036006571 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 273036006572 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 273036006573 active site 273036006574 Predicted transcriptional regulator [Transcription]; Region: COG2378 273036006575 HTH domain; Region: HTH_11; pfam08279 273036006576 CAAX protease self-immunity; Region: Abi; pfam02517 273036006577 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 273036006578 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 273036006579 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273036006580 putative active site [active] 273036006581 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 273036006582 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 273036006583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036006584 active site 273036006585 motif I; other site 273036006586 motif II; other site 273036006587 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 273036006588 Sodium Bile acid symporter family; Region: SBF; pfam01758 273036006589 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 273036006590 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 273036006591 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 273036006592 active site turn [active] 273036006593 phosphorylation site [posttranslational modification] 273036006594 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 273036006595 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 273036006596 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273036006597 putative active site [active] 273036006598 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 273036006599 putative hydrophobic ligand binding site [chemical binding]; other site 273036006600 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 273036006601 oxidoreductase; Provisional; Region: PRK07985 273036006602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273036006603 NAD(P) binding site [chemical binding]; other site 273036006604 active site 273036006605 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 273036006606 amidohydrolase; Region: amidohydrolases; TIGR01891 273036006607 metal binding site [ion binding]; metal-binding site 273036006608 dimer interface [polypeptide binding]; other site 273036006609 imidazolonepropionase; Validated; Region: PRK09356 273036006610 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 273036006611 active site 273036006612 urocanate hydratase; Provisional; Region: PRK05414 273036006613 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 273036006614 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273036006615 dimerization interface [polypeptide binding]; other site 273036006616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 273036006617 Transposase; Region: DDE_Tnp_ISL3; pfam01610 273036006618 formimidoylglutamase; Provisional; Region: PRK13775 273036006619 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 273036006620 putative active site [active] 273036006621 putative metal binding site [ion binding]; other site 273036006622 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 273036006623 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 273036006624 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273036006625 active site 273036006626 dimer interface [polypeptide binding]; other site 273036006627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 273036006628 MOSC domain; Region: MOSC; pfam03473 273036006629 3-alpha domain; Region: 3-alpha; pfam03475 273036006630 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 273036006631 active site 273036006632 catalytic residues [active] 273036006633 Uncharacterized conserved protein [Function unknown]; Region: COG1742 273036006634 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 273036006635 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 273036006636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273036006637 Walker A/P-loop; other site 273036006638 ATP binding site [chemical binding]; other site 273036006639 Q-loop/lid; other site 273036006640 ABC transporter signature motif; other site 273036006641 Walker B; other site 273036006642 D-loop; other site 273036006643 H-loop/switch region; other site 273036006644 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 273036006645 Predicted membrane protein [Function unknown]; Region: COG3152 273036006646 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 273036006647 active site 273036006648 DNA binding site [nucleotide binding] 273036006649 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 273036006650 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 273036006651 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 273036006652 homotetramer interface [polypeptide binding]; other site 273036006653 FMN binding site [chemical binding]; other site 273036006654 homodimer contacts [polypeptide binding]; other site 273036006655 putative active site [active] 273036006656 putative substrate binding site [chemical binding]; other site 273036006657 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 273036006658 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 273036006659 oligomer interface [polypeptide binding]; other site 273036006660 metal binding site [ion binding]; metal-binding site 273036006661 metal binding site [ion binding]; metal-binding site 273036006662 putative Cl binding site [ion binding]; other site 273036006663 aspartate ring; other site 273036006664 basic sphincter; other site 273036006665 hydrophobic gate; other site 273036006666 periplasmic entrance; other site 273036006667 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 273036006668 active site 273036006669 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 273036006670 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 273036006671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006672 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 273036006673 putative substrate translocation pore; other site 273036006674 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 273036006675 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 273036006676 lipoyl-biotinyl attachment site [posttranslational modification]; other site 273036006677 HlyD family secretion protein; Region: HlyD_3; pfam13437 273036006678 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 273036006679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006680 putative substrate translocation pore; other site 273036006681 Predicted membrane protein [Function unknown]; Region: COG4640 273036006682 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 273036006683 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 273036006684 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 273036006685 putative Zn2+ binding site [ion binding]; other site 273036006686 putative DNA binding site [nucleotide binding]; other site 273036006687 Uncharacterized conserved protein [Function unknown]; Region: COG1434 273036006688 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 273036006689 putative active site [active] 273036006690 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 273036006691 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 273036006692 Walker A/P-loop; other site 273036006693 ATP binding site [chemical binding]; other site 273036006694 Q-loop/lid; other site 273036006695 ABC transporter signature motif; other site 273036006696 Walker B; other site 273036006697 D-loop; other site 273036006698 H-loop/switch region; other site 273036006699 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 273036006700 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 273036006701 FtsX-like permease family; Region: FtsX; pfam02687 273036006702 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273036006703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273036006704 active site 273036006705 phosphorylation site [posttranslational modification] 273036006706 intermolecular recognition site; other site 273036006707 dimerization interface [polypeptide binding]; other site 273036006708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273036006709 DNA binding site [nucleotide binding] 273036006710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 273036006711 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273036006712 dimerization interface [polypeptide binding]; other site 273036006713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273036006714 dimer interface [polypeptide binding]; other site 273036006715 phosphorylation site [posttranslational modification] 273036006716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036006717 ATP binding site [chemical binding]; other site 273036006718 Mg2+ binding site [ion binding]; other site 273036006719 G-X-G motif; other site 273036006720 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 273036006721 LytTr DNA-binding domain; Region: LytTR; smart00850 273036006722 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 273036006723 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 273036006724 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 273036006725 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 273036006726 L-lactate permease; Region: Lactate_perm; cl00701 273036006727 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 273036006728 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 273036006729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036006730 Coenzyme A binding pocket [chemical binding]; other site 273036006731 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 273036006732 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 273036006733 NAD(P) binding site [chemical binding]; other site 273036006734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036006735 Coenzyme A binding pocket [chemical binding]; other site 273036006736 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 273036006737 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273036006738 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273036006739 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 273036006740 Predicted membrane protein [Function unknown]; Region: COG1511 273036006741 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 273036006742 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 273036006743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 273036006744 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 273036006745 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 273036006746 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 273036006747 Cl binding site [ion binding]; other site 273036006748 oligomer interface [polypeptide binding]; other site 273036006749 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 273036006750 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 273036006751 active site turn [active] 273036006752 phosphorylation site [posttranslational modification] 273036006753 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 273036006754 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 273036006755 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 273036006756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273036006757 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 273036006758 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 273036006759 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 273036006760 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 273036006761 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 273036006762 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 273036006763 MarR family; Region: MarR_2; pfam12802 273036006764 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 273036006765 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 273036006766 putative dimer interface [polypeptide binding]; other site 273036006767 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 273036006768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006769 putative substrate translocation pore; other site 273036006770 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 273036006771 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 273036006772 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 273036006773 DNA binding residues [nucleotide binding] 273036006774 dimer interface [polypeptide binding]; other site 273036006775 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 273036006776 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 273036006777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273036006778 active site 273036006779 phosphorylation site [posttranslational modification] 273036006780 intermolecular recognition site; other site 273036006781 dimerization interface [polypeptide binding]; other site 273036006782 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273036006783 DNA binding residues [nucleotide binding] 273036006784 dimerization interface [polypeptide binding]; other site 273036006785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 273036006786 Histidine kinase; Region: HisKA_3; pfam07730 273036006787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036006788 ATP binding site [chemical binding]; other site 273036006789 Mg2+ binding site [ion binding]; other site 273036006790 G-X-G motif; other site 273036006791 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 273036006792 GAF domain; Region: GAF; pfam01590 273036006793 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 273036006794 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 273036006795 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 273036006796 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 273036006797 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 273036006798 [4Fe-4S] binding site [ion binding]; other site 273036006799 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 273036006800 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 273036006801 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 273036006802 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 273036006803 molybdopterin cofactor binding site; other site 273036006804 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 273036006805 active site 273036006806 SAM binding site [chemical binding]; other site 273036006807 homodimer interface [polypeptide binding]; other site 273036006808 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 273036006809 [2Fe-2S] cluster binding site [ion binding]; other site 273036006810 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 273036006811 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273036006812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273036006813 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 273036006814 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 273036006815 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 273036006816 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 273036006817 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 273036006818 putative active site [active] 273036006819 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 273036006820 active site 273036006821 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 273036006822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036006823 Coenzyme A binding pocket [chemical binding]; other site 273036006824 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 273036006825 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 273036006826 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 273036006827 putative hydrophobic ligand binding site [chemical binding]; other site 273036006828 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 273036006829 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 273036006830 intersubunit interface [polypeptide binding]; other site 273036006831 YodA lipocalin-like domain; Region: YodA; pfam09223 273036006832 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 273036006833 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 273036006834 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 273036006835 Thioredoxin; Region: Thioredoxin_4; cl17273 273036006836 probable peptidoglycan synthesis protein 273036006837 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 273036006838 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 273036006839 Walker A/P-loop; other site 273036006840 ATP binding site [chemical binding]; other site 273036006841 Q-loop/lid; other site 273036006842 ABC transporter signature motif; other site 273036006843 Walker B; other site 273036006844 D-loop; other site 273036006845 H-loop/switch region; other site 273036006846 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 273036006847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036006848 dimer interface [polypeptide binding]; other site 273036006849 conserved gate region; other site 273036006850 putative PBP binding loops; other site 273036006851 ABC-ATPase subunit interface; other site 273036006852 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 273036006853 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273036006854 substrate binding pocket [chemical binding]; other site 273036006855 membrane-bound complex binding site; other site 273036006856 hinge residues; other site 273036006857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006858 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273036006859 putative substrate translocation pore; other site 273036006860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006861 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 273036006862 catalytic core [active] 273036006863 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 273036006864 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 273036006865 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 273036006866 B domain; Region: B; pfam02216 273036006867 B domain; Region: B; pfam02216 273036006868 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 273036006869 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 273036006870 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 273036006871 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 273036006872 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 273036006873 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 273036006874 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 273036006875 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273036006876 catalytic residue [active] 273036006877 biotin synthase; Validated; Region: PRK06256 273036006878 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273036006879 FeS/SAM binding site; other site 273036006880 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 273036006881 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 273036006882 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 273036006883 inhibitor-cofactor binding pocket; inhibition site 273036006884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036006885 catalytic residue [active] 273036006886 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 273036006887 AAA domain; Region: AAA_26; pfam13500 273036006888 ATP-binding ABC transporter 273036006889 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273036006890 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273036006891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273036006892 Walker A/P-loop; other site 273036006893 ATP binding site [chemical binding]; other site 273036006894 Q-loop/lid; other site 273036006895 ABC transporter signature motif; other site 273036006896 Walker B; other site 273036006897 D-loop; other site 273036006898 H-loop/switch region; other site 273036006899 Predicted membrane protein [Function unknown]; Region: COG2246 273036006900 GtrA-like protein; Region: GtrA; pfam04138 273036006901 glycerate kinase; Region: TIGR00045 273036006902 hypothetical protein; Provisional; Region: PRK11281 273036006903 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 273036006904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006905 putative substrate translocation pore; other site 273036006906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 273036006907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 273036006908 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 273036006909 putative phosphoesterase; Region: acc_ester; TIGR03729 273036006910 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 273036006911 Spore germination protein; Region: Spore_permease; cl17796 273036006912 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 273036006913 Amino acid permease; Region: AA_permease_2; pfam13520 273036006914 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 273036006915 Beta-lactamase; Region: Beta-lactamase; pfam00144 273036006916 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 273036006917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273036006918 NAD(P) binding site [chemical binding]; other site 273036006919 active site 273036006920 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 273036006921 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 273036006922 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 273036006923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006924 putative substrate translocation pore; other site 273036006925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036006927 dimer interface [polypeptide binding]; other site 273036006928 conserved gate region; other site 273036006929 ABC-ATPase subunit interface; other site 273036006930 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 273036006931 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 273036006932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036006933 dimer interface [polypeptide binding]; other site 273036006934 conserved gate region; other site 273036006935 putative PBP binding loops; other site 273036006936 ABC-ATPase subunit interface; other site 273036006937 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 273036006938 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 273036006939 Walker A/P-loop; other site 273036006940 ATP binding site [chemical binding]; other site 273036006941 Q-loop/lid; other site 273036006942 ABC transporter signature motif; other site 273036006943 Walker B; other site 273036006944 D-loop; other site 273036006945 H-loop/switch region; other site 273036006946 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 273036006947 conserved hypothetical protein 273036006948 amino acid transporter; Region: 2A0306; TIGR00909 273036006949 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 273036006950 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 273036006951 substrate binding pocket [chemical binding]; other site 273036006952 catalytic triad [active] 273036006953 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 273036006954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006955 putative substrate translocation pore; other site 273036006956 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 273036006957 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 273036006958 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 273036006959 Walker A/P-loop; other site 273036006960 ATP binding site [chemical binding]; other site 273036006961 Q-loop/lid; other site 273036006962 ABC transporter signature motif; other site 273036006963 Walker B; other site 273036006964 D-loop; other site 273036006965 H-loop/switch region; other site 273036006966 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 273036006967 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 273036006968 oligomer interface [polypeptide binding]; other site 273036006969 active site 273036006970 metal binding site [ion binding]; metal-binding site 273036006971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 273036006972 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 273036006973 Transcription elongation factor [Transcription]; Region: SPT5; COG5164 273036006974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 273036006975 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 273036006976 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 273036006977 active site 273036006978 FMN binding site [chemical binding]; other site 273036006979 substrate binding site [chemical binding]; other site 273036006980 3Fe-4S cluster binding site [ion binding]; other site 273036006981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036006982 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273036006983 putative substrate translocation pore; other site 273036006984 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 273036006985 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273036006986 Walker A/P-loop; other site 273036006987 ATP binding site [chemical binding]; other site 273036006988 Q-loop/lid; other site 273036006989 ABC transporter signature motif; other site 273036006990 Walker B; other site 273036006991 D-loop; other site 273036006992 H-loop/switch region; other site 273036006993 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273036006994 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 273036006995 Walker A/P-loop; other site 273036006996 ATP binding site [chemical binding]; other site 273036006997 Q-loop/lid; other site 273036006998 ABC transporter signature motif; other site 273036006999 Walker B; other site 273036007000 D-loop; other site 273036007001 H-loop/switch region; other site 273036007002 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273036007003 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 273036007004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036007005 dimer interface [polypeptide binding]; other site 273036007006 conserved gate region; other site 273036007007 putative PBP binding loops; other site 273036007008 ABC-ATPase subunit interface; other site 273036007009 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 273036007010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273036007011 dimer interface [polypeptide binding]; other site 273036007012 conserved gate region; other site 273036007013 putative PBP binding loops; other site 273036007014 ABC-ATPase subunit interface; other site 273036007015 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 273036007016 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 273036007017 substrate binding site [chemical binding]; other site 273036007018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 273036007019 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 273036007020 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 273036007021 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 273036007022 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 273036007023 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 273036007024 short chain dehydrogenase; Validated; Region: PRK08589 273036007025 classical (c) SDRs; Region: SDR_c; cd05233 273036007026 NAD(P) binding site [chemical binding]; other site 273036007027 active site 273036007028 AbgT putative transporter family; Region: ABG_transport; cl17431 273036007029 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 273036007030 Uncharacterized conserved protein [Function unknown]; Region: COG2128 273036007031 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 273036007032 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 273036007033 oxidoreductase 273036007034 truncated transposase; similar to Enterococcus faecium transposase 273036007035 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 273036007036 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 273036007037 nucleophilic elbow; other site 273036007038 catalytic triad; other site 273036007039 hypothetical protein 273036007040 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 273036007041 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 273036007042 cofactor binding site; other site 273036007043 DNA binding site [nucleotide binding] 273036007044 substrate interaction site [chemical binding]; other site 273036007045 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 273036007046 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 273036007047 active site 273036007048 substrate binding site [chemical binding]; other site 273036007049 metal binding site [ion binding]; metal-binding site 273036007050 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 273036007051 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 273036007052 active site 273036007053 tetramer interface; other site 273036007054 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 273036007055 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 273036007056 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 273036007057 GntP family permease; Region: GntP_permease; pfam02447 273036007058 fructuronate transporter; Provisional; Region: PRK10034; cl15264 273036007059 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 273036007060 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 273036007061 N- and C-terminal domain interface [polypeptide binding]; other site 273036007062 active site 273036007063 catalytic site [active] 273036007064 metal binding site [ion binding]; metal-binding site 273036007065 carbohydrate binding site [chemical binding]; other site 273036007066 ATP binding site [chemical binding]; other site 273036007067 Transcriptional regulators [Transcription]; Region: GntR; COG1802 273036007068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273036007069 DNA-binding site [nucleotide binding]; DNA binding site 273036007070 FCD domain; Region: FCD; pfam07729 273036007071 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 273036007072 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 273036007073 DNA binding residues [nucleotide binding] 273036007074 dimer interface [polypeptide binding]; other site 273036007075 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 273036007076 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 273036007077 synthetase active site [active] 273036007078 NTP binding site [chemical binding]; other site 273036007079 metal binding site [ion binding]; metal-binding site 273036007080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 273036007081 Predicted membrane protein [Function unknown]; Region: COG1289 273036007082 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 273036007083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273036007084 D-galactonate transporter; Region: 2A0114; TIGR00893 273036007085 putative substrate translocation pore; other site 273036007086 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 273036007087 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 273036007088 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 273036007089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273036007090 Walker A/P-loop; other site 273036007091 ATP binding site [chemical binding]; other site 273036007092 Q-loop/lid; other site 273036007093 ABC transporter signature motif; other site 273036007094 Walker B; other site 273036007095 D-loop; other site 273036007096 H-loop/switch region; other site 273036007097 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 273036007098 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 273036007099 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 273036007100 Uncharacterized membrane protein [Function unknown]; Region: COG3949 273036007101 Predicted esterase [General function prediction only]; Region: COG0400 273036007102 putative hydrolase; Provisional; Region: PRK11460 273036007103 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 273036007104 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 273036007105 Zn binding site [ion binding]; other site 273036007106 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 273036007107 Zn binding site [ion binding]; other site 273036007108 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 273036007109 MarR family; Region: MarR; pfam01047 273036007110 Predicted acetyltransferase [General function prediction only]; Region: COG2388 273036007111 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 273036007112 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 273036007113 putative metal binding site [ion binding]; other site 273036007114 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 273036007115 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 273036007116 dimer interface [polypeptide binding]; other site 273036007117 FMN binding site [chemical binding]; other site 273036007118 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 273036007119 NAD binding site [chemical binding]; other site 273036007120 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 273036007121 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273036007122 active site 273036007123 motif I; other site 273036007124 motif II; other site 273036007125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273036007126 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 273036007127 Walker A/P-loop; other site 273036007128 ATP binding site [chemical binding]; other site 273036007129 Q-loop/lid; other site 273036007130 ABC transporter signature motif; other site 273036007131 Walker B; other site 273036007132 D-loop; other site 273036007133 H-loop/switch region; other site 273036007134 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 273036007135 active site 273036007136 catalytic site [active] 273036007137 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 273036007138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036007139 Coenzyme A binding pocket [chemical binding]; other site 273036007140 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 273036007141 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 273036007142 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 273036007143 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 273036007144 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 273036007145 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 273036007146 EamA-like transporter family; Region: EamA; pfam00892 273036007147 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 273036007148 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 273036007149 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 273036007150 catalytic residues [active] 273036007151 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 273036007152 active site 273036007153 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 273036007154 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 273036007155 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 273036007156 active site turn [active] 273036007157 phosphorylation site [posttranslational modification] 273036007158 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 273036007159 HPr interaction site; other site 273036007160 glycerol kinase (GK) interaction site [polypeptide binding]; other site 273036007161 active site 273036007162 phosphorylation site [posttranslational modification] 273036007163 pyruvate oxidase; Provisional; Region: PRK08611 273036007164 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 273036007165 PYR/PP interface [polypeptide binding]; other site 273036007166 tetramer interface [polypeptide binding]; other site 273036007167 dimer interface [polypeptide binding]; other site 273036007168 TPP binding site [chemical binding]; other site 273036007169 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 273036007170 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 273036007171 TPP-binding site [chemical binding]; other site 273036007172 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 273036007173 membrane protein 273036007174 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273036007175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273036007176 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 273036007177 putative dimerization interface [polypeptide binding]; other site 273036007178 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 273036007179 Surface antigen [General function prediction only]; Region: COG3942 273036007180 CHAP domain; Region: CHAP; pfam05257 273036007181 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 273036007182 homodimer interface [polypeptide binding]; other site 273036007183 catalytic residues [active] 273036007184 NAD binding site [chemical binding]; other site 273036007185 substrate binding pocket [chemical binding]; other site 273036007186 flexible flap; other site 273036007187 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 273036007188 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 273036007189 dimer interface [polypeptide binding]; other site 273036007190 active site 273036007191 superantigen-like protein; Reviewed; Region: PRK13039 273036007192 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 273036007193 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 273036007194 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 273036007195 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 273036007196 DNA binding site [nucleotide binding] 273036007197 active site 273036007198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036007199 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 273036007200 Walker A motif; other site 273036007201 ATP binding site [chemical binding]; other site 273036007202 Walker B motif; other site 273036007203 arginine finger; other site 273036007204 UvrB/uvrC motif; Region: UVR; pfam02151 273036007205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273036007206 Walker A motif; other site 273036007207 ATP binding site [chemical binding]; other site 273036007208 Walker B motif; other site 273036007209 arginine finger; other site 273036007210 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 273036007211 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 273036007212 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 273036007213 G1 box; other site 273036007214 GTP/Mg2+ binding site [chemical binding]; other site 273036007215 Switch I region; other site 273036007216 G2 box; other site 273036007217 G3 box; other site 273036007218 Switch II region; other site 273036007219 G4 box; other site 273036007220 G5 box; other site 273036007221 Nucleoside recognition; Region: Gate; pfam07670 273036007222 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 273036007223 Nucleoside recognition; Region: Gate; pfam07670 273036007224 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 273036007225 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 273036007226 Protein export membrane protein; Region: SecD_SecF; cl14618 273036007227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 273036007228 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 273036007229 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 273036007230 Glutamate binding site [chemical binding]; other site 273036007231 homodimer interface [polypeptide binding]; other site 273036007232 NAD binding site [chemical binding]; other site 273036007233 catalytic residues [active] 273036007234 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 273036007235 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 273036007236 active site 273036007237 substrate binding site [chemical binding]; other site 273036007238 trimer interface [polypeptide binding]; other site 273036007239 CoA binding site [chemical binding]; other site 273036007240 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 273036007241 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 273036007242 metal-binding site [ion binding] 273036007243 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 273036007244 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 273036007245 metal-binding site [ion binding] 273036007246 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 273036007247 Soluble P-type ATPase [General function prediction only]; Region: COG4087 273036007248 D-lactate dehydrogenase; Validated; Region: PRK08605 273036007249 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 273036007250 homodimer interface [polypeptide binding]; other site 273036007251 ligand binding site [chemical binding]; other site 273036007252 NAD binding site [chemical binding]; other site 273036007253 catalytic site [active] 273036007254 transaminase; Reviewed; Region: PRK08068 273036007255 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273036007256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273036007257 homodimer interface [polypeptide binding]; other site 273036007258 catalytic residue [active] 273036007259 phytoene desaturase; Region: crtI_fam; TIGR02734 273036007260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 273036007261 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 273036007262 active site lid residues [active] 273036007263 substrate binding pocket [chemical binding]; other site 273036007264 catalytic residues [active] 273036007265 substrate-Mg2+ binding site; other site 273036007266 aspartate-rich region 1; other site 273036007267 aspartate-rich region 2; other site 273036007268 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 273036007269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 273036007270 active site 273036007271 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 273036007272 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 273036007273 Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237 273036007274 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273036007275 Surface antigen [General function prediction only]; Region: COG3942 273036007276 CHAP domain; Region: CHAP; pfam05257 273036007277 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 273036007278 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 273036007279 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 273036007280 catalytic triad [active] 273036007281 catalytic triad [active] 273036007282 oxyanion hole [active] 273036007283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036007284 Coenzyme A binding pocket [chemical binding]; other site 273036007285 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 273036007286 N-acetyl-D-glucosamine binding site [chemical binding]; other site 273036007287 catalytic residue [active] 273036007288 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 273036007289 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 273036007290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 273036007291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 273036007292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 273036007293 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 273036007294 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 273036007295 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 273036007296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273036007297 active site 273036007298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273036007299 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 273036007300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 273036007301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 273036007302 short chain dehydrogenase; Provisional; Region: PRK12937 273036007303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273036007304 NAD(P) binding site [chemical binding]; other site 273036007305 active site 273036007306 conserved hypothetical protein 273036007307 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 273036007308 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 273036007309 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 273036007310 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 273036007311 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 273036007312 Nucleoside recognition; Region: Gate; pfam07670 273036007313 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 273036007314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 273036007315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 273036007316 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 273036007317 Phosphotransferase enzyme family; Region: APH; pfam01636 273036007318 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 273036007319 active site 273036007320 ATP binding site [chemical binding]; other site 273036007321 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 273036007322 active site 273036007323 ATP binding site [chemical binding]; other site 273036007324 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 273036007325 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 273036007326 quinone interaction residues [chemical binding]; other site 273036007327 active site 273036007328 catalytic residues [active] 273036007329 FMN binding site [chemical binding]; other site 273036007330 substrate binding site [chemical binding]; other site 273036007331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 273036007332 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 273036007333 dimer interface [polypeptide binding]; other site 273036007334 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 273036007335 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 273036007336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 273036007337 Predicted acyl esterases [General function prediction only]; Region: COG2936 273036007338 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 273036007339 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 273036007340 tetramerization interface [polypeptide binding]; other site 273036007341 active site 273036007342 pantoate--beta-alanine ligase; Region: panC; TIGR00018 273036007343 Pantoate-beta-alanine ligase; Region: PanC; cd00560 273036007344 active site 273036007345 ATP-binding site [chemical binding]; other site 273036007346 pantoate-binding site; other site 273036007347 HXXH motif; other site 273036007348 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 273036007349 oligomerization interface [polypeptide binding]; other site 273036007350 active site 273036007351 metal binding site [ion binding]; metal-binding site 273036007352 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 273036007353 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 273036007354 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 273036007355 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 273036007356 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 273036007357 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 273036007358 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273036007359 NAD binding site [chemical binding]; other site 273036007360 dimer interface [polypeptide binding]; other site 273036007361 substrate binding site [chemical binding]; other site 273036007362 amino acid transporter; Region: 2A0306; TIGR00909 273036007363 conserved hypothetical protein 273036007364 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 273036007365 catalytic residue [active] 273036007366 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 273036007367 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 273036007368 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 273036007369 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 273036007370 acyl-activating enzyme (AAE) consensus motif; other site 273036007371 AMP binding site [chemical binding]; other site 273036007372 active site 273036007373 CoA binding site [chemical binding]; other site 273036007374 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 273036007375 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 273036007376 choline dehydrogenase; Validated; Region: PRK02106 273036007377 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 273036007378 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 273036007379 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 273036007380 tetramerization interface [polypeptide binding]; other site 273036007381 NAD(P) binding site [chemical binding]; other site 273036007382 catalytic residues [active] 273036007383 Predicted transcriptional regulators [Transcription]; Region: COG1510 273036007384 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 273036007385 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 273036007386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273036007387 FeS/SAM binding site; other site 273036007388 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 273036007389 Class III ribonucleotide reductase; Region: RNR_III; cd01675 273036007390 effector binding site; other site 273036007391 active site 273036007392 Zn binding site [ion binding]; other site 273036007393 glycine loop; other site 273036007394 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 273036007395 Citrate transporter; Region: CitMHS; pfam03600 273036007396 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 273036007397 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 273036007398 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 273036007399 Flavodoxin; Region: Flavodoxin_1; pfam00258 273036007400 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 273036007401 FAD binding pocket [chemical binding]; other site 273036007402 FAD binding motif [chemical binding]; other site 273036007403 catalytic residues [active] 273036007404 NAD binding pocket [chemical binding]; other site 273036007405 phosphate binding motif [ion binding]; other site 273036007406 beta-alpha-beta structure motif; other site 273036007407 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 273036007408 catalytic residues [active] 273036007409 dimer interface [polypeptide binding]; other site 273036007410 FtsX-like permease family; Region: FtsX; pfam02687 273036007411 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 273036007412 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 273036007413 Walker A/P-loop; other site 273036007414 ATP binding site [chemical binding]; other site 273036007415 Q-loop/lid; other site 273036007416 ABC transporter signature motif; other site 273036007417 Walker B; other site 273036007418 D-loop; other site 273036007419 H-loop/switch region; other site 273036007420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 273036007421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273036007422 ATP binding site [chemical binding]; other site 273036007423 Mg2+ binding site [ion binding]; other site 273036007424 G-X-G motif; other site 273036007425 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273036007426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273036007427 active site 273036007428 phosphorylation site [posttranslational modification] 273036007429 intermolecular recognition site; other site 273036007430 dimerization interface [polypeptide binding]; other site 273036007431 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273036007432 DNA binding site [nucleotide binding] 273036007433 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 273036007434 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 273036007435 dimer interface [polypeptide binding]; other site 273036007436 active site 273036007437 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 273036007438 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 273036007439 MarR family; Region: MarR_2; pfam12802 273036007440 Predicted esterase [General function prediction only]; Region: COG0627 273036007441 S-formylglutathione hydrolase; Region: PLN02442 273036007442 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 273036007443 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 273036007444 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 273036007445 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 273036007446 ligand binding site [chemical binding]; other site 273036007447 flexible hinge region; other site 273036007448 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 273036007449 carbamate kinase; Reviewed; Region: PRK12686 273036007450 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 273036007451 putative substrate binding site [chemical binding]; other site 273036007452 nucleotide binding site [chemical binding]; other site 273036007453 nucleotide binding site [chemical binding]; other site 273036007454 homodimer interface [polypeptide binding]; other site 273036007455 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 273036007456 ornithine carbamoyltransferase; Validated; Region: PRK02102 273036007457 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 273036007458 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 273036007459 arginine deiminase; Provisional; Region: PRK01388 273036007460 Arginine repressor [Transcription]; Region: ArgR; COG1438 273036007461 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 273036007462 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 273036007463 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 273036007464 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 273036007465 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 273036007466 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 273036007467 active site 273036007468 Zn binding site [ion binding]; other site 273036007469 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 273036007470 HTH domain; Region: HTH_11; pfam08279 273036007471 PRD domain; Region: PRD; pfam00874 273036007472 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 273036007473 active site 273036007474 P-loop; other site 273036007475 phosphorylation site [posttranslational modification] 273036007476 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273036007477 active site 273036007478 phosphorylation site [posttranslational modification] 273036007479 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 273036007480 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 273036007481 active site 273036007482 P-loop; other site 273036007483 phosphorylation site [posttranslational modification] 273036007484 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 273036007485 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273036007486 active site 273036007487 phosphorylation site [posttranslational modification] 273036007488 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 273036007489 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 273036007490 Predicted membrane protein [Function unknown]; Region: COG1511 273036007491 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 273036007492 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 273036007493 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 273036007494 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 273036007495 CHAP domain; Region: CHAP; pfam05257 273036007496 Isochorismatase family; Region: Isochorismatase; pfam00857 273036007497 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 273036007498 catalytic triad [active] 273036007499 conserved cis-peptide bond; other site 273036007500 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 273036007501 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 273036007502 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 273036007503 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 273036007504 preprotein translocase SecA subunit-like protein 273036007505 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 273036007506 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 273036007507 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 273036007508 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 273036007509 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 273036007510 SecY translocase; Region: SecY; pfam00344 273036007511 surface expressed Ser-Thr rich repeat protein 273036007512 conserved hypothetical protein 273036007513 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 273036007514 methionine sulfoxide reductase A; Provisional; Region: PRK05528 273036007515 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 273036007516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273036007517 Coenzyme A binding pocket [chemical binding]; other site 273036007518 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 273036007519 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 273036007520 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 273036007521 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 273036007522 Chain length determinant protein; Region: Wzz; cl15801 273036007523 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 273036007524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 273036007525 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 273036007526 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 273036007527 DXD motif; other site 273036007528 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 273036007529 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 273036007530 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 273036007531 Acyltransferase family; Region: Acyl_transf_3; pfam01757 273036007532 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 273036007533 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 273036007534 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 273036007535 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 273036007536 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 273036007537 metal binding site [ion binding]; metal-binding site 273036007538 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 273036007539 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 273036007540 substrate binding site [chemical binding]; other site 273036007541 glutamase interaction surface [polypeptide binding]; other site 273036007542 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 273036007543 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 273036007544 catalytic residues [active] 273036007545 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 273036007546 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 273036007547 putative active site [active] 273036007548 oxyanion strand; other site 273036007549 catalytic triad [active] 273036007550 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 273036007551 putative active site pocket [active] 273036007552 4-fold oligomerization interface [polypeptide binding]; other site 273036007553 metal binding residues [ion binding]; metal-binding site 273036007554 3-fold/trimer interface [polypeptide binding]; other site 273036007555 conserved hypothetical protein 273036007556 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 273036007557 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 273036007558 NAD binding site [chemical binding]; other site 273036007559 dimerization interface [polypeptide binding]; other site 273036007560 product binding site; other site 273036007561 substrate binding site [chemical binding]; other site 273036007562 zinc binding site [ion binding]; other site 273036007563 catalytic residues [active] 273036007564 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 273036007565 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 273036007566 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 273036007567 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 273036007568 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 273036007569 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 273036007570 putative active site [active] 273036007571 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 273036007572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 273036007573 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 273036007574 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 273036007575 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 273036007576 Walker A/P-loop; other site 273036007577 ATP binding site [chemical binding]; other site 273036007578 Q-loop/lid; other site 273036007579 ABC transporter signature motif; other site 273036007580 Walker B; other site 273036007581 D-loop; other site 273036007582 H-loop/switch region; other site 273036007583 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 273036007584 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 273036007585 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 273036007586 Walker A/P-loop; other site 273036007587 ATP binding site [chemical binding]; other site 273036007588 Q-loop/lid; other site 273036007589 ABC transporter signature motif; other site 273036007590 Walker B; other site 273036007591 D-loop; other site 273036007592 H-loop/switch region; other site 273036007593 hypothetical protein; Provisional; Region: PRK13661 273036007594 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 273036007595 Uncharacterized conserved protein [Function unknown]; Region: COG1912 273036007596 Uncharacterized conserved protein [Function unknown]; Region: COG2353 273036007597 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 273036007598 Strictosidine synthase; Region: Str_synth; pfam03088 273036007599 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 273036007600 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 273036007601 active site residue [active] 273036007602 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 273036007603 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 273036007604 putative substrate binding pocket [chemical binding]; other site 273036007605 AC domain interface; other site 273036007606 catalytic triad [active] 273036007607 AB domain interface; other site 273036007608 interchain disulfide; other site 273036007609 hypothetical protein; Validated; Region: PRK07668 273036007610 Predicted transcriptional regulators [Transcription]; Region: COG1695 273036007611 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 273036007612 DinB superfamily; Region: DinB_2; pfam12867 273036007613 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 273036007614 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 273036007615 transmembrane helices; other site 273036007616 Predicted permeases [General function prediction only]; Region: RarD; COG2962 273036007617 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 273036007618 hypothetical protein; Provisional; Region: PRK07758 273036007619 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 273036007620 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 273036007621 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 273036007622 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 273036007623 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 273036007624 Walker A/P-loop; other site 273036007625 ATP binding site [chemical binding]; other site 273036007626 Q-loop/lid; other site 273036007627 ABC transporter signature motif; other site 273036007628 Walker B; other site 273036007629 D-loop; other site 273036007630 H-loop/switch region; other site 273036007631 FtsX-like permease family; Region: FtsX; pfam02687 273036007632 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 273036007633 DNA-binding site [nucleotide binding]; DNA binding site 273036007634 RNA-binding motif; other site 273036007635 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 273036007636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273036007637 non-specific DNA binding site [nucleotide binding]; other site 273036007638 salt bridge; other site 273036007639 sequence-specific DNA binding site [nucleotide binding]; other site 273036007640 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 273036007641 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 273036007642 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 273036007643 ParB-like nuclease domain; Region: ParBc; pfam02195 273036007644 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 273036007645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273036007646 S-adenosylmethionine binding site [chemical binding]; other site 273036007647 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 273036007648 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 273036007649 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 273036007650 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 273036007651 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 273036007652 trmE is a tRNA modification GTPase; Region: trmE; cd04164 273036007653 G1 box; other site 273036007654 GTP/Mg2+ binding site [chemical binding]; other site 273036007655 Switch I region; other site 273036007656 G2 box; other site 273036007657 Switch II region; other site 273036007658 G3 box; other site 273036007659 G4 box; other site 273036007660 G5 box; other site 273036007661 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 273036007662 ribonuclease P; Reviewed; Region: rnpA; PRK00499 273036007663 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399